NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|6319582|ref|NP_009664|]
View 

Snd3p [Saccharomyces cerevisiae S288C]

Protein Classification

PHO88 family protein( domain architecture ID 10562121)

PHO88 family protein similar to Saccharomyces cerevisiae SRP-independent targeting protein 3 that functions in the SND pathway, a SRP (signal recognition particle) and GET (guided entry of tail-anchored proteins) independent pathway for targeting a broad range of substrate proteins to the endoplasmic reticulum

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Pho88 pfam10032
Phosphate transport (Pho88); Members of this family of proteins are involved in regulating ...
 6-181 1.59e-105

Phosphate transport (Pho88); Members of this family of proteins are involved in regulating inorganic phosphate transport, as well as telomere length regulation and maintenance. Family members such as SND3 (SRP-independent targeting protein 3, encoded by PHO88, also known as YBR106W) is localized to the endoplasmic reticulum (ER). SND3 works together with SND1 and SND2; these proteins function in parallel with the SRP and GET pathways to target a broad range of substrates to the ER. The SND proteins constitute an alternative targeting route to the ER. SND3/PHO88 was first identified as a Saccharomyces cerevisiae protein involved in inorganic phosphate transport. Functional analysis revealed that Loss of SND3 has been shown to affect secretion of the yeast acid phosphatase.


:

Pssm-ID: 431002  Cd Length: 175  Bit Score: 299.89  E-value: 1.59e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319582      6 SNIIIMLVMMQLSRRIDMEDPTIIMYIRILYCSSIGISWIIYQMARKRIVAKNDMTTMKYVEPGNAMSGEGEKLQVTTVR 85
Cdd:pfam10032   1 TNLVISLGMMQVSKKIDFEDPEVLFYVRIAYVVSQLIILGVYLYIKSKIKKKNDLTTLKYVEPASPMSQEEGKLVTTTVR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319582     86 DYDLKEIDSAIKSIYTGMAMMGFMHLYLKYTNPLFMQSISPVKSALEHNEVKIHLFGKPATGDLKRPFK-APSLFGGMGQ 164
Cdd:pfam10032  81 DYDLAQLKKLIKSQLMGVAMMAFMHLYMKYTNPLLIQSIMPLKGALENNLVKIHLFGKPATGDLKRPFKaAAGFFGAAGE 160

                         170
                  ....*....|....*..
gi 6319582    165 tgPKTDKKSIEEAERAG 181
Cdd:pfam10032 161 --PKTDKKSIEAAEKAG 175
 
Name Accession Description Interval E-value
Pho88 pfam10032
Phosphate transport (Pho88); Members of this family of proteins are involved in regulating ...
 6-181 1.59e-105

Phosphate transport (Pho88); Members of this family of proteins are involved in regulating inorganic phosphate transport, as well as telomere length regulation and maintenance. Family members such as SND3 (SRP-independent targeting protein 3, encoded by PHO88, also known as YBR106W) is localized to the endoplasmic reticulum (ER). SND3 works together with SND1 and SND2; these proteins function in parallel with the SRP and GET pathways to target a broad range of substrates to the ER. The SND proteins constitute an alternative targeting route to the ER. SND3/PHO88 was first identified as a Saccharomyces cerevisiae protein involved in inorganic phosphate transport. Functional analysis revealed that Loss of SND3 has been shown to affect secretion of the yeast acid phosphatase.


Pssm-ID: 431002  Cd Length: 175  Bit Score: 299.89  E-value: 1.59e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319582      6 SNIIIMLVMMQLSRRIDMEDPTIIMYIRILYCSSIGISWIIYQMARKRIVAKNDMTTMKYVEPGNAMSGEGEKLQVTTVR 85
Cdd:pfam10032   1 TNLVISLGMMQVSKKIDFEDPEVLFYVRIAYVVSQLIILGVYLYIKSKIKKKNDLTTLKYVEPASPMSQEEGKLVTTTVR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319582     86 DYDLKEIDSAIKSIYTGMAMMGFMHLYLKYTNPLFMQSISPVKSALEHNEVKIHLFGKPATGDLKRPFK-APSLFGGMGQ 164
Cdd:pfam10032  81 DYDLAQLKKLIKSQLMGVAMMAFMHLYMKYTNPLLIQSIMPLKGALENNLVKIHLFGKPATGDLKRPFKaAAGFFGAAGE 160

                         170
                  ....*....|....*..
gi 6319582    165 tgPKTDKKSIEEAERAG 181
Cdd:pfam10032 161 --PKTDKKSIEAAEKAG 175
PHO88 COG5065
Protein involved in inorganic phosphate transport [Inorganic ion transport and metabolism];
1-181 2.81e-97

Protein involved in inorganic phosphate transport [Inorganic ion transport and metabolism];


Pssm-ID: 227397  Cd Length: 185  Bit Score: 279.46  E-value: 2.81e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319582    1 MNPQVSNIIIMLVMMQLSRRIDMEDPTIIMYIRILYCSS--IGISWIIYQMARkrIVAKNDMTTMKYVEPGNAMSG-EGE 77
Cdd:COG5065   1 MNPQVVNIAISIASMQISRRIDFQDPKIIWYLRILYLCSnlIQLMFSIYIMRR--IKATNDCTKLKYVEPASPFSGgSEE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319582   78 KLQVTTVRDYDLKEIDSAIKSIYTGMAMMGFMHLYLKYTNPLFMQSISPVKSALEHNEVKIHLFGKPATGDLKRPFKAPS 157
Cdd:COG5065  79 KLVETTVRDYDLSELTKASRSAVIGFAIMSFMHLYMKYAQPLFVQSISPLRSLFLNNLVTIYVFNKPALGELRRPFKAPG 158

                       170       180
                ....*....|....*....|....
gi 6319582  158 LFGGMGQTgPKTDKKSIEEAERAG 181
Cdd:COG5065 159 LFGGIGQA-PKTDKKSIKEAELTK 181
 
Name Accession Description Interval E-value
Pho88 pfam10032
Phosphate transport (Pho88); Members of this family of proteins are involved in regulating ...
 6-181 1.59e-105

Phosphate transport (Pho88); Members of this family of proteins are involved in regulating inorganic phosphate transport, as well as telomere length regulation and maintenance. Family members such as SND3 (SRP-independent targeting protein 3, encoded by PHO88, also known as YBR106W) is localized to the endoplasmic reticulum (ER). SND3 works together with SND1 and SND2; these proteins function in parallel with the SRP and GET pathways to target a broad range of substrates to the ER. The SND proteins constitute an alternative targeting route to the ER. SND3/PHO88 was first identified as a Saccharomyces cerevisiae protein involved in inorganic phosphate transport. Functional analysis revealed that Loss of SND3 has been shown to affect secretion of the yeast acid phosphatase.


Pssm-ID: 431002  Cd Length: 175  Bit Score: 299.89  E-value: 1.59e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319582      6 SNIIIMLVMMQLSRRIDMEDPTIIMYIRILYCSSIGISWIIYQMARKRIVAKNDMTTMKYVEPGNAMSGEGEKLQVTTVR 85
Cdd:pfam10032   1 TNLVISLGMMQVSKKIDFEDPEVLFYVRIAYVVSQLIILGVYLYIKSKIKKKNDLTTLKYVEPASPMSQEEGKLVTTTVR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319582     86 DYDLKEIDSAIKSIYTGMAMMGFMHLYLKYTNPLFMQSISPVKSALEHNEVKIHLFGKPATGDLKRPFK-APSLFGGMGQ 164
Cdd:pfam10032  81 DYDLAQLKKLIKSQLMGVAMMAFMHLYMKYTNPLLIQSIMPLKGALENNLVKIHLFGKPATGDLKRPFKaAAGFFGAAGE 160

                         170
                  ....*....|....*..
gi 6319582    165 tgPKTDKKSIEEAERAG 181
Cdd:pfam10032 161 --PKTDKKSIEAAEKAG 175
PHO88 COG5065
Protein involved in inorganic phosphate transport [Inorganic ion transport and metabolism];
1-181 2.81e-97

Protein involved in inorganic phosphate transport [Inorganic ion transport and metabolism];


Pssm-ID: 227397  Cd Length: 185  Bit Score: 279.46  E-value: 2.81e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319582    1 MNPQVSNIIIMLVMMQLSRRIDMEDPTIIMYIRILYCSS--IGISWIIYQMARkrIVAKNDMTTMKYVEPGNAMSG-EGE 77
Cdd:COG5065   1 MNPQVVNIAISIASMQISRRIDFQDPKIIWYLRILYLCSnlIQLMFSIYIMRR--IKATNDCTKLKYVEPASPFSGgSEE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319582   78 KLQVTTVRDYDLKEIDSAIKSIYTGMAMMGFMHLYLKYTNPLFMQSISPVKSALEHNEVKIHLFGKPATGDLKRPFKAPS 157
Cdd:COG5065  79 KLVETTVRDYDLSELTKASRSAVIGFAIMSFMHLYMKYAQPLFVQSISPLRSLFLNNLVTIYVFNKPALGELRRPFKAPG 158

                       170       180
                ....*....|....*....|....
gi 6319582  158 LFGGMGQTgPKTDKKSIEEAERAG 181
Cdd:COG5065 159 LFGGIGQA-PKTDKKSIKEAELTK 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH