|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_AKR3C1 |
cd19119 |
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ... |
22-321 |
0e+00 |
|
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).
Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 517.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 22 EIYFSLNNGVRIPALGLGTANPHEKLAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLEDGSIKREDLFITTKV 101
Cdd:cd19119 1 EISFKLNTGASIPALGLGTASPHEDRAEVKEAVEAAIKEGYRHIDTAYAYETEDFVGEAIKRAIDDGSIKREELFITTKV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 102 WPVLWDEVDRSLNESLKALGLEYVDLLLQHWPLCFEKIKDPkgiSGLVKTPVDDSGKTMYAADGDYLETYKQLEKIYLDP 181
Cdd:cd19119 81 WPTFYDEVERSLDESLKALGLDYVDLLLVHWPVCFEKDSDD---SGKPFTPVNDDGKTRYAASGDHITTYKQLEKIYLDG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 182 ndhRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGAPNLKIPLVKKLAE 261
Cdd:cd19119 158 ---RAKAIGVSNYSIVYLERLIKECKVVPAVNQVELHPHLPQMDLRDFCFKHGILVTAYSPLGSHGAPNLKNPLVKKIAE 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 262 KYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFASLTKDELQELNDFGEKYPVRFI 321
Cdd:cd19119 235 KYNVSTGDILISYHVRQGVIVLPKSLKPVRIVSNGKIVSLTKEDLQKLDDIGEKYPVRFI 294
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
33-310 |
1.97e-108 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 316.73 E-value: 1.97e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 33 IPALGLGTANPHEklAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLedgsIKREDLFITTKVWPVLW--DEVD 110
Cdd:cd19071 1 MPLIGLGTYKLKP--EETAEAVLAALEAGYRHIDTAAAYGNEAEVGEAIRESG----VPREELFITTKLWPTDHgyERVR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 111 RSLNESLKALGLEYVDLLLQHWPLCFEKIKdpkgisglvktpvddsgktmyaADGDYLETYKQLEKIYldpNDHRVRAIG 190
Cdd:cd19071 75 EALEESLKDLGLDYLDLYLIHWPVPGKEGG----------------------SKEARLETWRALEELV---DEGLVRSIG 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 191 VSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGAPNLKIPLVKKLAEKYNVTGNDL 270
Cdd:cd19071 130 VSNFNVEHLEELLAAARIKPAVNQIELHPYLQQKELVEFCKEHGIVVQAYSPLGRGRRPLLDDPVLKEIAKKYGKTPAQV 209
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 398365091 271 LISYHIRQGTIVIPRSLNPVRISSSIEFA--SLTKDELQELN 310
Cdd:cd19071 210 LLRWALQRGVVVIPKSSNPERIKENLDVFdfELSEEDMAAID 251
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
29-310 |
3.06e-99 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 293.50 E-value: 3.06e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 29 NGVRIPALGLGTANPheKLAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELledgSIKREDLFITTKVWPvlW-- 106
Cdd:COG0656 1 NGVEIPALGLGTWQL--PGEEAAAAVRTALEAGYRHIDTAAMYGNEEGVGEAIAAS----GVPREELFVTTKVWN--Dnh 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 107 --DEVDRSLNESLKALGLEYVDLLLQHWPlcfekikdpkgisglvktpvddsgktmyaADGDYLETYKQLEKIYldpNDH 184
Cdd:COG0656 73 gyDDTLAAFEESLERLGLDYLDLYLIHWP-----------------------------GPGPYVETWRALEELY---EEG 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 185 RVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGsHGAPnLKIPLVKKLAEKYN 264
Cdd:COG0656 121 LIRAIGVSNFDPEHLEELLAETGVKPAVNQVELHPYLQQRELLAFCREHGIVVEAYSPLG-RGKL-LDDPVLAEIAEKHG 198
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 398365091 265 VTGNDLLISYHIRQGTIVIPRSLNPVRISSSIE---FaSLTKDELQELN 310
Cdd:COG0656 199 KTPAQVVLRWHLQRGVVVIPKSVTPERIRENLDafdF-ELSDEDMAAID 246
|
|
| AKR_AKR3D1 |
cd19121 |
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ... |
24-312 |
1.98e-96 |
|
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.
Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 287.51 E-value: 1.98e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 24 YFSLNNGVRIPALGLGTAnpHEKLAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLeDGSIKREDLFITTKVWP 103
Cdd:cd19121 3 SFKLNTGASIPAVGLGTW--QAKAGEVKAAVAHALKIGYRHIDGALCYQNEDEVGEGIKEAI-AGGVKREDLFVTTKLWS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 104 VLWDEVDRSLNESLKALGLEYVDLLLQHWPLCFekikDPKGISGLVKTPVDdsGKTMYAADGDYLETYKQLEKIYldpND 183
Cdd:cd19121 80 TYHRRVELCLDRSLKSLGLDYVDLYLVHWPVLL----NPNGNHDLFPTLPD--GSRDLDWDWNHVDTWKQMEKVL---KT 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 184 HRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGAPNLKIPLVKKLAEKY 263
Cdd:cd19121 151 GKTKAIGVSNYSIPYLEELLKHATVVPAVNQVENHPYLPQQELVDFCKEKGILIEAYSPLGSTGSPLISDEPVVEIAKKH 230
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 398365091 264 NVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFASLTKDELQELNDF 312
Cdd:cd19121 231 NVGPGTVLISYQVARGAVVLPKSVTPDRIKSNLEIIDLDDEDMNKLNDI 279
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
24-318 |
3.81e-93 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 279.55 E-value: 3.81e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 24 YFSLNNGVRIPALGLGTANPHEKLaETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLEDGSIKREDLFITTKVW- 102
Cdd:cd19116 2 TIKLNDGNEIPAIALGTWKLKDDE-GVRQAVKHAIEAGYRHIDTAYLYGNEAEVGEAIREKIAEGVVKREDLFITTKLWn 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 103 ----PvlwDEVDRSLNESLKALGLEYVDLLLQHWPLCFEKIKDPkgisgLVKTPVDDSgktmyaaDGDYLETYKQLEKIY 178
Cdd:cd19116 81 syheR---EQVEPALRESLKRLGLDYVDLYLIHWPVAFKENNDS-----ESNGDGSLS-------DIDYLETWRGMEDLV 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 179 ---LdpndhrVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGA------- 248
Cdd:cd19116 146 klgL------TRSIGVSNFNSEQINRLLSNCNIKPAVNQIEVHPTLTQEKLVAYCQSNGIVVMAYSPFGRLVPrgqtnpp 219
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398365091 249 PNLKIPLVKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIE---FaSLTKDELQELNDFGEKYPV 318
Cdd:cd19116 220 PRLDDPTLVAIAKKYGKTTAQIVLRYLIDRGVVPIPKSSNKKRIKENIDifdF-QLTPEEVAALNSFNTNQRV 291
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
24-319 |
8.53e-92 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 275.76 E-value: 8.53e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 24 YFSLNNGVRIPALGLGT--ANPheklAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLEDGSIKREDLFITTKV 101
Cdd:cd19125 2 FFKLNTGAKIPAVGLGTwqADP----GVVGNAVKTAIKEGYRHIDCAAIYGNEKEIGKALKKLFEDGVVKREDLFITSKL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 102 W-----PvlwDEVDRSLNESLKALGLEYVDLLLQHWPLCFEKikDPKGISGLVKTPVDDSGktmyaadgdyleTYKQLEK 176
Cdd:cd19125 78 WctdhaP---EDVPPALEKTLKDLQLDYLDLYLIHWPVRLKK--GAHMPEPEEVLPPDIPS------------TWKAMEK 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 177 IYldpNDHRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGAPNLKI--- 253
Cdd:cd19125 141 LV---DSGKVRAIGVSNFSVKKLEDLLAVARVPPAVNQVECHPGWQQDKLHEFCKSKGIHLSAYSPLGSPGTTWVKKnvl 217
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 254 --PLVKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFA--SLTKDELQELNDFGEKYPVR 319
Cdd:cd19125 218 kdPIVTKVAEKLGKTPAQVALRWGLQRGTSVLPKSTNEERIKENIDVFdwSIPEEDFAKFSSIEQQRRVL 287
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
25-316 |
2.34e-88 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 267.06 E-value: 2.34e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 25 FSLNNGVRIPALGLGTAnpHEKLAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKelleDGSIKREDLFITTKVWPV 104
Cdd:cd19117 6 FKLNTGAEIPAVGLGTW--QSKPNEVAKAVEAALKAGYRHIDTAAIYGNEEEVGQGIK----DSGVPREEIFITTKLWCT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 105 LWDEVDRSLNESLKALGLEYVDLLLQHWPLCFekikDPKGISglvKTPVDDSGKTMYAADGDYLETYKQLEKIyldPNDH 184
Cdd:cd19117 80 WHRRVEEALDQSLKKLGLDYVDLYLMHWPVPL----DPDGND---FLFKKDDGTKDHEPDWDFIKTWELMQKL---PATG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 185 RVRAIGVSNFSIEYLERLIKECRVK--PTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGAPNLKIPLVKKLAEK 262
Cdd:cd19117 150 KVKAIGVSNFSIKNLEKLLASPSAKivPAVNQIELHPLLPQPKLVDFCKSKGIHATAYSPLGSTNAPLLKEPVIIKIAKK 229
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 398365091 263 YNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFASLTKDELQELNDFGEKY 316
Cdd:cd19117 230 HGKTPAQVIISWGLQRGYSVLPKSVTPSRIESNFKLFTLSDEEFKEIDELHKEY 283
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
25-319 |
1.34e-87 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 265.81 E-value: 1.34e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 25 FSLNNGVRIPALGLGT--ANPheklAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLEDGSIKREDLFITTKVW 102
Cdd:cd19154 4 ITLSNGVKMPLIGLGTwqSKG----AEGITAVRTALKAGYRLIDTAFLYQNEEAIGEALAELLEEGVVKREDLFITTKLW 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 103 PVLW--DEVDRSLNESLKALGLEYVDLLLQHWPLCFEKIKDPKGIsglvktpvDDSGKTMYAaDGDYLETYKQLEKIYld 180
Cdd:cd19154 80 THEHapEDVEEALRESLKKLQLEYVDLYLIHAPAAFKDDEGESGT--------MENGMSIHD-AVDVEDVWRGMEKVY-- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 181 pNDHRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGAPN---------- 250
Cdd:cd19154 149 -DEGLTKAIGVSNFNNDQIQRILDNARVKPHNNQVECHLYFPQKELVEFCKKHNISVTSYATLGSPGRANftkstgvspa 227
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 398365091 251 ---LKIPLVKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIE---FaSLTKDELQELNdfGEKYPVR 319
Cdd:cd19154 228 pnlLQDPIVKAIAEKHGKTPAQVLLRYLLQRGIAVIPKSATPSRIKENFNifdF-SLSEEDMATLE--EIEKSLR 299
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
26-309 |
1.76e-82 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 250.75 E-value: 1.76e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 26 SLNNGVRIPALGLGT-ANPHEklaETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKelleDGSIKREDLFITTKVW-- 102
Cdd:cd19131 3 TLNDGNTIPQLGLGVwQVSND---EAASAVREALEVGYRSIDTAAIYGNEEGVGKAIR----ASGVPREELFITTKLWns 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 103 PVLWDEVDRSLNESLKALGLEYVDLLLQHWPLcfekikdpkgisglvktpvddsgktmyAADGDYLETYKQLEKIYldpN 182
Cdd:cd19131 76 DQGYDSTLRAFDESLRKLGLDYVDLYLIHWPV---------------------------PAQDKYVETWKALIELK---K 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 183 DHRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGApnLKIPLVKKLAEK 262
Cdd:cd19131 126 EGRVKSIGVSNFTIEHLQRLIDETGVVPVVNQIELHPRFQQRELRAFHAKHGIQTESWSPLGQGGL--LSDPVIGEIAEK 203
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 398365091 263 YNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSI---EFaSLTKDELQEL 309
Cdd:cd19131 204 HGKTPAQVVIRWHLQNGLVVIPKSVTPSRIAENFdvfDF-ELDADDMQAI 252
|
|
| AKR_AKR1A1-4 |
cd19106 |
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ... |
27-336 |
4.80e-82 |
|
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 251.54 E-value: 4.80e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 27 LNNGVRIPALGLGTANphEKLAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELL-EDGSIKREDLFITTKVW--- 102
Cdd:cd19106 1 LHTGQKMPLIGLGTWK--SKPGQVKAAVKYALDAGYRHIDCAAVYGNEQEVGEALKEKVgPGKAVPREDLFVTSKLWntk 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 103 --PvlwDEVDRSLNESLKALGLEYVDLLLQHWPLCFEKIKDPkgisglvkTPVDDSGKTMYAaDGDYLETYKQLEKIYld 180
Cdd:cd19106 79 hhP---EDVEPALRKTLKDLQLDYLDLYLIHWPYAFERGDNP--------FPKNPDGTIRYD-STHYKETWKAMEKLV-- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 181 pNDHRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGAP--------NLK 252
Cdd:cd19106 145 -DKGLVKAIGLSNFNSRQIDDILSVARIKPAVLQVECHPYLAQNELIAHCKARGLVVTAYSPLGSPDRPwakpdepvLLE 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 253 IPLVKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIE---FaSLTKDELQELNDFgekypvrfiDEPFAAIL 329
Cdd:cd19106 224 EPKVKALAKKYNKSPAQILLRWQVQRGVVVIPKSVTPSRIKQNIQvfdF-TLSPEEMKQLDAL---------NRNWRYIV 293
|
....*..
gi 398365091 330 PEFTGNG 336
Cdd:cd19106 294 PMITVDG 300
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
33-310 |
1.28e-81 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 248.70 E-value: 1.28e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 33 IPALGLGTANPHeKLAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLEDGSIKREDLFITTKVWP--VLWDEVD 110
Cdd:cd19136 1 MPILGLGTFRLR-GEEEVRQAVDAALKAGYRLIDTASVYRNEADIGKALRDLLPKYGLSREDIFITSKLAPkdQGYEKAR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 111 RSLNESLKALGLEYVDLLLQHWPlcfekikdpkgisGLVKTPVDDSGKTMYAAdgdylETYKQLEKIYldpNDHRVRAIG 190
Cdd:cd19136 80 AACLGSLERLGTDYLDLYLIHWP-------------GVQGLKPSDPRNAELRR-----ESWRALEDLY---KEGKLRAIG 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 191 VSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGAPNLKIPLVKKLAEKYNVTGNDL 270
Cdd:cd19136 139 VSNYTVRHLEELLKYCEVPPAVNQVEFHPHLVQKELLKFCKDHGIHLQAYSSLGSGDLRLLEDPTVLAIAKKYGRTPAQV 218
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 398365091 271 LISYHIRQGTIVIPRSLNPVRISSSIEFA--SLTKDELQELN 310
Cdd:cd19136 219 LLRWALQQGIGVIPKSTNPERIAENIKVFdfELSEEDMAELN 260
|
|
| AKR_AKR3B1-3 |
cd19118 |
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ... |
27-311 |
8.80e-81 |
|
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.
Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 247.71 E-value: 8.80e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 27 LNNGVRIPALGLGT--ANPheklAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELL-EDGSIKREDLFITTKVW- 102
Cdd:cd19118 1 LNTGNKIPAIGLGTwqAEP----GEVGAAVKIALKAGYRHLDLAKVYQNQHEVGQALKELLkEEPGVKREDLFITSKLWn 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 103 ----PvlwDEVDRSLNESLKALGLEYVDLLLQHWPLCFEKIKDPKGisglvKTPVDDSGKTMYAADGDYL-ETYKQLEKI 177
Cdd:cd19118 77 nshrP---EYVEPALDDTLKELGLDYLDLYLIHWPVAFKPTGDLNP-----LTAVPTNGGEVDLDLSVSLvDTWKAMVEL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 178 yldPNDHRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSH--GAPNL-KIP 254
Cdd:cd19118 149 ---KKTGKVKSIGVSNFSIDHLQAIIEETGVVPAVNQIEAHPLLLQDELVDYCKSKNIHITAYSPLGNNlaGLPLLvQHP 225
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 398365091 255 LVKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFASLTKDELQELND 311
Cdd:cd19118 226 EVKAIAAKLGKTPAQVLIAWGIQRGHSVIPKSVTPSRIRSNFEQVELSDDEFNAVTA 282
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
24-321 |
5.98e-80 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 245.78 E-value: 5.98e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 24 YFSLNNGVRIPALGLGTANPHEklAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLEDGSIKREDLFITTKVW- 102
Cdd:cd19123 3 TLPLSNGDLIPALGLGTWKSKP--GEVGQAVKQALEAGYRHIDCAAIYGNEAEIGAALAEVFKEGKVKREDLWITSKLWn 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 103 ----PvlwDEVDRSLNESLKALGLEYVDLLLQHWPLCFEKikdpkgisglvKTPVDDSGKTMYA-ADGDYLETYKQLEKI 177
Cdd:cd19123 81 nshaP---EDVLPALEKTLADLQLDYLDLYLMHWPVALKK-----------GVGFPESGEDLLSlSPIPLEDTWRAMEEL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 178 YldpNDHRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGAPN------- 250
Cdd:cd19123 147 V---DKGLCRHIGVSNFSVKKLEDLLATARIKPAVNQVELHPYLQQPELLAFCRDNGIHLTAYSPLGSGDRPAamkaege 223
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 398365091 251 ---LKIPLVKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFA--SLTKDELQELNDFGEKYpvRFI 321
Cdd:cd19123 224 pvlLEDPVINKIAEKHGASPAQVLIAWAIQRGTVVIPKSVNPERIQQNLEAAevELDASDMATIAALDRHH--RYV 297
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
25-310 |
4.58e-79 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 242.68 E-value: 4.58e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 25 FSLNNGVRIPALGLGTANPHEKlAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKElledGSIKREDLFITTKVW-- 102
Cdd:cd19157 2 VTLNNGVKMPWLGLGVFKVEEG-SEVVNAVKTALKNGYRSIDTAAIYGNEEGVGKGIKE----SGIPREELFITSKVWna 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 103 PVLWDEVDRSLNESLKALGLEYVDLLLQHWPLcfekikdpkgisglvktpvddsgktmyaaDGDYLETYKQLEKIYldpN 182
Cdd:cd19157 77 DQGYDSTLKAFEASLERLGLDYLDLYLIHWPV-----------------------------KGKYKETWKALEKLY---K 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 183 DHRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGApnLKIPLVKKLAEK 262
Cdd:cd19157 125 DGRVRAIGVSNFQVHHLEDLLADAEIVPMVNQVEFHPRLTQKELRDYCKKQGIQLEAWSPLMQGQL--LDNPVLKEIAEK 202
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 398365091 263 YNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFA--SLTKDELQELN 310
Cdd:cd19157 203 YNKSVAQVILRWDLQNGVVTIPKSIKEHRIIENADVFdfELSQEDMDKID 252
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
30-311 |
1.10e-75 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 234.70 E-value: 1.10e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 30 GVRIPALGLGTANphEKLAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLEDGSIKREDLFITTKVWPVL--WD 107
Cdd:cd19111 1 GFPMPVIGLGTYQ--SPPEEVRAAVDYALFVGYRHIDTALSYQNEKAIGEALKWWLKNGKLKREEVFITTKLPPVYleFK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 108 EVDRSLNESLKALGLEYVDLLLQHWPLCFEkIKDPKGISGLVKTPVddsgktmyaadgdyLETYKQLEKIYldpNDHRVR 187
Cdd:cd19111 79 DTEKSLEKSLENLKLPYVDLYLIHHPCGFV-NKKDKGERELASSDV--------------TSVWRAMEALV---SEGKVK 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 188 AIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGAPN----------LKIPLVK 257
Cdd:cd19111 141 SIGLSNFNPRQINKILAYAKVKPSNLQLECHAYLQQRELRKFCNKKNIVVTAYAPLGSPGRANqslwpdqpdlLEDPTVL 220
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 398365091 258 KLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEF--ASLTKDELQELND 311
Cdd:cd19111 221 AIAKELDKTPAQVLLRFVLQRGTGVLPKSTNKERIEENFEVfdFELTEEHFKKLKT 276
|
|
| AKR_AKR3E1 |
cd19122 |
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ... |
25-314 |
4.54e-73 |
|
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.
Pssm-ID: 381348 [Multi-domain] Cd Length: 291 Bit Score: 228.28 E-value: 4.54e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 25 FSLNNGVRIPALGLGT-ANPHEKlAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELL-EDGSIKREDLFITTKVW 102
Cdd:cd19122 1 FTLNNGVKIPAVGFGTfANEGAK-GETYAAVTKALDVGYRHLDCAWFYLNEDEVGDAVRDFLkENPSVKREDLFICTKVW 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 103 PVL--WDEVDRSLNESLKALGLEYVDLLLQHWPLCFEKikdpkgisglvktpvDDSGKTMYAADGDYL----------ET 170
Cdd:cd19122 80 NHLhePEDVKWSIDNSLKNLKLDYIDLFLVHWPIAAEK---------------NDQRSPKLGPDGKYVilkdltenpePT 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 171 YKQLEKIYldpNDHRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSH---- 246
Cdd:cd19122 145 WRAMEEIY---ESGKAKAIGVSNWTIPGLKKLLSFAKVKPHVNQIEIHPFLPNEELVDYCFSNDILPEAYSPLGSQnqvp 221
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 247 --GAPNLKIPLVKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFASLTKDELQELNDFGE 314
Cdd:cd19122 222 stGERVSENPTLNEVAEKGGYSLAQVLIAWGLRRGYVVLPKSSTPSRIESNFKSIELSDEDFEAINQVAK 291
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
27-309 |
5.16e-73 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 226.69 E-value: 5.16e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 27 LNNGVRIPALGLGT--ANPhekLAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKelleDGSIKREDLFITTKVWP- 103
Cdd:cd19133 3 LNNGVEMPILGFGVfqIPD---PEECERAVLEAIKAGYRLIDTAAAYGNEEAVGRAIK----KSGIPREELFITTKLWIq 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 104 -VLWDEVDRSLNESLKALGLEYVDLLLQHWPLcfekikdpkgisglvktpvddsgktmyaadGDYLETYKQLEKIYldpN 182
Cdd:cd19133 76 dAGYEKAKKAFERSLKRLGLDYLDLYLIHQPF------------------------------GDVYGAWRAMEELY---K 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 183 DHRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGsHGAPNL-KIPLVKKLAE 261
Cdd:cd19133 123 EGKIRAIGVSNFYPDRLVDLILHNEVKPAVNQIETHPFNQQIEAVEFLKKYGVQIEAWGPFA-EGRNNLfENPVLTEIAE 201
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 398365091 262 KYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIE---FAsLTKDELQEL 309
Cdd:cd19133 202 KYGKSVAQVILRWLIQRGIVVIPKSVRPERIAENFDifdFE-LSDEDMEAI 251
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
30-317 |
9.36e-73 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 226.34 E-value: 9.36e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 30 GVRIPALGLGTANPHEKLAETK------QAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLedgsIKREDLFITTKVWP 103
Cdd:cd19120 1 GSKIPAIAFGTGTAWYKSGDDDiqrdlvDSVKLALKAGFRHIDTAEMYGNEKEVGEALKESG----VPREDLFITTKVSP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 104 VLWDeVDRSLNESLKALGLEYVDLLLQHWPlCFEKIKDPkgisglvktpvddsgktmyaadgDYLETYKQLEKIYldpND 183
Cdd:cd19120 77 GIKD-PREALRKSLAKLGVDYVDLYLIHSP-FFAKEGGP-----------------------TLAEAWAELEALK---DA 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 184 HRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHL--PQMELRKFCFMHDILLTAYSPLGS--HGAPNLKIPLVKKL 259
Cdd:cd19120 129 GLVRSIGVSNFRIEDLEELLDTAKIKPAVNQIEFHPYLypQQPALLEYCREHGIVVSAYSPLSPltRDAGGPLDPVLEKI 208
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 260 AEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFAS--LTKDELQELNDFGEKYP 317
Cdd:cd19120 209 AEKYGVTPAQVLLRWALQKGIVVVTTSSKEERMKEYLEAFDfeLTEEEVEEIDKAGKQKH 268
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
27-310 |
1.10e-72 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 226.13 E-value: 1.10e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 27 LNNGVRIPALGLGT-ANPHEklaETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKElledGSIKREDLFITTKVW--P 103
Cdd:cd19127 3 LNNGVEMPALGLGVfQTPPE---ETADAVATALADGYRLIDTAAAYGNEREVGEGIRR----SGVDRSDIFVTTKLWisD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 104 VLWDEVDRSLNESLKALGLEYVDLLLQHWPlcfekikdpkgisglVKTPVDDSgktmyaadgdyLETYKQLEKIYldpND 183
Cdd:cd19127 76 YGYDKALRGFDASLRRLGLDYVDLYLLHWP---------------VPNDFDRT-----------IQAYKALEKLL---AE 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 184 HRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGS---HGAPN-------LKI 253
Cdd:cd19127 127 GRVRAIGVSNFTPEHLERLIDATTVVPAVNQVELHPYFSQKDLRAFHRRLGIVTQAWSPIGGvmrYGASGptgpgdvLQD 206
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 254 PLVKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIE---FAsLTKDELQELN 310
Cdd:cd19127 207 PTITGLAEKYGKTPAQIVLRWHLQNGVSAIPKSVHPERIAENIDifdFA-LSAEDMAAID 265
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
27-311 |
3.20e-71 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 221.93 E-value: 3.20e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 27 LNNGVRIPALGLGTANPHEKlAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKElledGSIKREDLFITTKVW--PV 104
Cdd:cd19126 3 LNNGTRMPWLGLGVFQTPDG-DETERAVQTALENGYRSIDTAAIYKNEEGVGEAIRE----SGVPREELFVTTKLWndDQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 105 LWDEVDRSLNESLKALGLEYVDLLLQHWPlcfekikdpkgisglvktpvddsgktmyaADGDYLETYKQLEKIYldpNDH 184
Cdd:cd19126 78 RARRTEDAFQESLDRLGLDYVDLYLIHWP-----------------------------GKDKFIDTWKALEKLY---ASG 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 185 RVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGApnLKIPLVKKLAEKYN 264
Cdd:cd19126 126 KVKAIGVSNFQEHHLEELLAHADVVPAVNQVEFHPYLTQKELRGYCKSKGIVVEAWSPLGQGGL--LSNPVLAAIGEKYG 203
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 398365091 265 VTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEF--ASLTKDELQELND 311
Cdd:cd19126 204 KSAAQVVLRWDIQHGVVTIPKSVHASRIKENADIfdFELSEDDMTAIDA 252
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
33-310 |
2.39e-70 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 219.45 E-value: 2.39e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 33 IPALGLGTANPHEKlaETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELledgSIKREDLFITTKVWPVLW--DEVD 110
Cdd:cd19073 1 IPALGLGTWQLRGD--DCANAVKEALELGYRHIDTAEIYNNEAEVGEAIAES----GVPREDLFITTKVWRDHLrpEDLK 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 111 RSLNESLKALGLEYVDLLLQHWPlcfEKIKDPKgisglvktpvddsgktmyaadgdylETYKQLEKIYldpNDHRVRAIG 190
Cdd:cd19073 75 KSVDRSLEKLGTDYVDLLLIHWP---NPTVPLE-------------------------ETLGALKELK---EAGKVKSIG 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 191 VSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGAPNLkiPLVKKLAEKYNVTGNDL 270
Cdd:cd19073 124 VSNFTIELLEEALDISPLPIAVNQVEFHPFLYQAELLEYCRENDIVITAYSPLARGEVLRD--PVIQEIAEKYDKTPAQV 201
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 398365091 271 LISYHIRQGTIVIPRSLNPVRISSSIEFA--SLTKDELQELN 310
Cdd:cd19073 202 ALRWLVQKGIVVIPKASSEDHLKENLAIFdwELTSEDVAKID 243
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
27-310 |
3.30e-70 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 220.08 E-value: 3.30e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 27 LNNGVRIPALGLGTANPHEKlAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKElledGSIKREDLFITTKVWPVL- 105
Cdd:cd19156 3 LANGVEMPRLGLGVWRVQDG-AEAENAVKWAIEAGYRHIDTAAIYKNEEGVGQGIRE----SGVPREEVFVTTKLWNSDq 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 106 -WDEVDRSLNESLKALGLEYVDLLLQHWPlcfekikdpkgisglvktpvddsgktmyaADGDYLETYKQLEKIYldpNDH 184
Cdd:cd19156 78 gYESTLAAFEESLEKLGLDYVDLYLIHWP-----------------------------VKGKFKDTWKAFEKLY---KEK 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 185 RVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGShgAPNLKIPLVKKLAEKYN 264
Cdd:cd19156 126 KVRAIGVSNFHEHHLEELLKSCKVAPMVNQIELHPLLTQEPLRKFCKEKNIAVEAWSPLGQ--GKLLSNPVLKAIGKKYG 203
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 398365091 265 VTGNDLLISYHIRQGTIVIPRSLNPVRISSS---IEFaSLTKDELQELN 310
Cdd:cd19156 204 KSAAQVIIRWDIQHGIITIPKSVHEERIQENfdvFDF-ELTAEEIRQID 251
|
|
| AKR_BaDH-like |
cd19129 |
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ... |
28-320 |
3.73e-70 |
|
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 220.79 E-value: 3.73e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 28 NNGVRIPALGLGTANPheKLAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLEDGSIKREDLFITTKVW----- 102
Cdd:cd19129 1 NGSGAIPALGFGTLIP--DPSATRNAVKAALEAGFRHFDCAERYRNEAEVGEAMQEVFKAGKIRREDLFVTTKLWntnhr 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 103 PvlwDEVDRSLNESLKALGLEYVDLLLQHWPLCFE--KIKDPKGISGLVktpVDDSGKTMyaadgdyLETYKQLEKIYld 180
Cdd:cd19129 79 P---ERVKPAFEASLKRLQLDYLDLYLIHTPFAFQpgDEQDPRDANGNV---IYDDGVTL-------LDTWRAMERLV-- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 181 pNDHRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGAPN-LKIPLVKKL 259
Cdd:cd19129 144 -DEGRCKAIGLSDVSLEKLREIFEAARIKPAVVQVESHPYLPEWELLDFCKNHGIVLQAFAPLGHGMEPKlLEDPVITAI 222
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 398365091 260 AEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFASLTKDELQELNDfGEKYPVRF 320
Cdd:cd19129 223 ARRVNKTPAQVLLAWAIQRGTALLTTSKTPSRIRENFDISTLPEDAMREINE-GIKTRYRF 282
|
|
| AKR_AKR1B1-19 |
cd19107 |
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ... |
30-332 |
2.19e-69 |
|
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.
Pssm-ID: 381333 [Multi-domain] Cd Length: 307 Bit Score: 219.21 E-value: 2.19e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 30 GVRIPALGLGTANphEKLAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLEDGSIKREDLFITTKVWPVLWDE- 108
Cdd:cd19107 1 GAKMPILGLGTWK--SPPGQVTEAVKVAIDAGYRHIDCAYVYQNENEVGEAIQEKIKEQVVKREDLFIVSKLWCTFHEKg 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 109 -VDRSLNESLKALGLEYVDLLLQHWPLCFEKIKDPkgisglvkTPVDDSGKTMyAADGDYLETYKQLEKIYldpNDHRVR 187
Cdd:cd19107 79 lVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEL--------FPLDESGNVI-PSDTTFLDTWEAMEELV---DEGLVK 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 188 AIGVSNFSIEYLERLIKE--CRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGAPN--------LKIPLVK 257
Cdd:cd19107 147 AIGVSNFNHLQIERILNKpgLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWakpedpslLEDPKIK 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 398365091 258 KLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEF--ASLTKDELQELNDFGEKYpvRFIDEPFAAILPEF 332
Cdd:cd19107 227 EIAAKHNKTTAQVLIRFPIQRNLVVIPKSVTPERIAENFKVfdFELSSEDMATILSFNRNW--RACALLSCSSHKDY 301
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
27-312 |
2.79e-69 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 217.58 E-value: 2.79e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 27 LNNGVRIPALGLGTAN----PHEklaetkqAVKAAIK-AGYRHIDTAWAYETEPFVGEAIKElledGSIKREDLFITTKV 101
Cdd:cd19135 7 LSNGVEMPILGLGTSHsggySHE-------AVVYALKeCGYRHIDTAKRYGCEELLGKAIKE----SGVPREDLFLTTKL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 102 WPVLW--DEVDRSLNESLKALGLEYVDLLLQHWPLCFEKIKDPKGISglvktpvddsgktmyaadgdyLETYKQLEKIYl 179
Cdd:cd19135 76 WPSDYgyESTKQAFEASLKRLGVDYLDLYLLHWPDCPSSGKNVKETR---------------------AETWRALEELY- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 180 dpNDHRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGShgAPNLKIPLVKKL 259
Cdd:cd19135 134 --DEGLCRAIGVSNFLIEHLEQLLEDCSVVPHVNQVEFHPFQNPVELIEYCRDNNIVFEGYCPLAK--GKALEEPTVTEL 209
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 398365091 260 AEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRI--SSSIEFASLTKDELQELNDF 312
Cdd:cd19135 210 AKKYQKTPAQILIRWSIQNGVVTIPKSTKEERIkeNCQVFDFSLSEEDMATLDSL 264
|
|
| AKR_AKR1E1-2 |
cd19110 |
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ... |
32-309 |
6.75e-69 |
|
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.
Pssm-ID: 381336 [Multi-domain] Cd Length: 301 Bit Score: 217.90 E-value: 6.75e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 32 RIPALGLGT--ANPheklAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLEDGSIKREDLFITTKVWPVLWDE- 108
Cdd:cd19110 3 DIPAVGLGTwkASP----GEVTEAVKVAIDAGYRHFDCAYLYHNESEVGAGIREKIKEGVVRREDLFIVSKLWCTCHKKs 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 109 -VDRSLNESLKALGLEYVDLLLQHWPLCFEkikdpkgiSGLVKTPVDDSGKTMyAADGDYLETYKQLEKIYLdpnDHRVR 187
Cdd:cd19110 79 lVKTACTRSLKALKLNYLDLYLIHWPMGFK--------PGEPDLPLDRSGMVI-PSDTDFLDTWEAMEDLVI---EGLVK 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 188 AIGVSNFSIEYLERLIKE--CRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLG--SHGAPNLKIPLVKKLAEKY 263
Cdd:cd19110 147 NIGVSNFNHEQLERLLNKpgLRVKPVTNQIECHPYLTQKKLISFCQSRNVSVTAYRPLGgsCEGVDLIDDPVIQRIAKKH 226
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 398365091 264 NVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEF--ASLTKDELQEL 309
Cdd:cd19110 227 GKSPAQILIRFQIQRNVIVIPKSVTPSRIKENIQVfdFELTEHDMDNL 274
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
26-309 |
1.42e-67 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 214.70 E-value: 1.42e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 26 SLNNGVRIPALGLGTANPHEKLAETkqAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLEDGSIKREDLFITTKVWPV- 104
Cdd:cd19155 5 TFNNGEKMPVVGLGTWQSSPEEIET--AVDTALEAGYRHIDTAYVYRNEAAIGNVLKKWIDSGKVKREELFIVTKLPPGg 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 105 -LWDEVDRSLNESLKALGLEYVDLLLQHWPLCFEKIKDPKGIsglvktpVDDSGKTMYAADGDYLETYKQLEKIYldpND 183
Cdd:cd19155 83 nRREKVEKFLLKSLEKLQLDYVDLYLIHFPVGSLSKEDDSGK-------LDPTGEHKQDYTTDLLDIWKAMEAQV---DQ 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 184 HRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGAPN------------- 250
Cdd:cd19155 153 GLTRSIGLSNFNREQMARILKNARIKPANLQVELHVYLQQKDLVDFCSTHSITVTAYAPLGSPGAAHfspgtgspsgssp 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398365091 251 --LKIPLVKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEF--ASLTKDELQEL 309
Cdd:cd19155 233 dlLQDPVVKAIAERHGKSPAQVLLRWLMQRGVVVIPKSTNAARIKENFQVfdFELTEADMAKL 295
|
|
| AKR_AKR1C1-35 |
cd19108 |
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ... |
27-292 |
2.31e-67 |
|
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.
Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 213.63 E-value: 2.31e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 27 LNNGVRIPALGLGTANPHEKL-AETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLEDGSIKREDLFITTKVW--- 102
Cdd:cd19108 5 LNDGHFIPVLGFGTYAPEEVPkSKALEATKLAIDAGFRHIDSAYLYQNEEEVGQAIRSKIADGTVKREDIFYTSKLWctf 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 103 --PVLwdeVDRSLNESLKALGLEYVDLLLQHWPLCFEKIKDPKgisglvktPVDDSGKTMYAADgDYLETYKQLEKIyld 180
Cdd:cd19108 85 hrPEL---VRPALEKSLKKLQLDYVDLYLIHFPVALKPGEELF--------PKDENGKLIFDTV-DLCATWEAMEKC--- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 181 PNDHRVRAIGVSNFSIEYLERLIKE--CRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGAPN-------- 250
Cdd:cd19108 150 KDAGLAKSIGVSNFNRRQLEMILNKpgLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAYSALGSQRDKEwvdqnspv 229
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 398365091 251 -LKIPLVKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRI 292
Cdd:cd19108 230 lLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSFNEKRI 272
|
|
| AKR_GlAR-like |
cd19128 |
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ... |
34-310 |
4.96e-67 |
|
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 212.00 E-value: 4.96e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 34 PALGLGTANPHEKLAEtkQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLEDGSIKREDLFITTKVWPVL--WDEVDR 111
Cdd:cd19128 2 PRLGFGTYKITESESK--EAVKNAIKAGYRHIDCAYYYGNEAFIGIAFSEIFKDGGVKREDLFITSKLWPTMhqPENVKE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 112 SLNESLKALGLEYVDLLLQHWPLCFEK-----IKDPKGISGLVKTPVDDSGKTMYAAdgdyletykQLEKIyldpndhrV 186
Cdd:cd19128 80 QLLITLQDLQLEYLDLFLIHWPLAFDMdtdgdPRDDNQIQSLSKKPLEDTWRAMEQC---------VDEKL--------T 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 187 RAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPL-GSHGAPN---LKIPLVKKLAEK 262
Cdd:cd19128 143 KNIGVSNYSTKLLTDLLNYCKIKPFMNQIECHPYFQNDKLIKFCIENNIHVTAYRPLgGSYGDGNltfLNDSELKALATK 222
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 398365091 263 YNVTGNDLLISYHIRQGT---IVIPRSLNPVRISSSIEFAS--LTKDELQELN 310
Cdd:cd19128 223 YNTTPPQVIIAWHLQKWPknySVIPKSANKSRCQQNFDINDlaLTKEDMDAIN 275
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
27-310 |
5.32e-65 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 205.97 E-value: 5.32e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 27 LNNGVRIPALGLGTANphEKLAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKElledGSIKREDLFITTKVWPV-- 104
Cdd:cd19132 1 LNDGTQIPAIGFGTYP--LKGDEGVEAVVAALQAGYRLLDTAFNYENEGAVGEAVRR----SGVPREELFVTTKLPGRhh 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 105 LWDEVDRSLNESLKALGLEYVDLLLQHWPLcfekikdPKgisglvktpvddsgktmyaaDGDYLETYKQLekIYLDpNDH 184
Cdd:cd19132 75 GYEEALRTIEESLYRLGLDYVDLYLIHWPN-------PS--------------------RDLYVEAWQAL--IEAR-EEG 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 185 RVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGsHGAPNLKIPLVKKLAEKYN 264
Cdd:cd19132 125 LVRSIGVSNFLPEHLDRLIDETGVTPAVNQIELHPYFPQAEQRAYHREHGIVTQSWSPLG-RGSGLLDEPVIKAIAEKHG 203
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 398365091 265 VTGNDLLISYHIRQGTIVIPRSLNPVRISSSIE---FaSLTKDELQELN 310
Cdd:cd19132 204 KTPAQVVLRWHVQLGVVPIPKSANPERQRENLAifdF-ELSDEDMAAIA 251
|
|
| AKR_AKR4A_4B |
cd19124 |
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ... |
29-307 |
9.25e-65 |
|
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.
Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 206.35 E-value: 9.25e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 29 NGVRIPALGLGTANPHEKLAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLEDGSIK-REDLFITTKVWP--VL 105
Cdd:cd19124 1 SGQTMPVIGMGTASDPPSPEDIKAAVLEAIEVGYRHFDTAAAYGTEEALGEALAEALRLGLVKsRDELFVTSKLWCsdAH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 106 WDEVDRSLNESLKALGLEYVDLLLQHWPLCFEKikdpkgisGLVKTPVDDSgktmYAADGDYLETYKQLEKIyldpndHR 185
Cdd:cd19124 81 PDLVLPALKKSLRNLQLEYVDLYLIHWPVSLKP--------GKFSFPIEEE----DFLPFDIKGVWEAMEEC------QR 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 186 V---RAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGAPN-----LKIPLVK 257
Cdd:cd19124 143 LgltKAIGVSNFSCKKLQELLSFATIPPAVNQVEMNPAWQQKKLREFCKANGIHVTAYSPLGAPGTKWgsnavMESDVLK 222
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 398365091 258 KLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFA--SLTKDELQ 307
Cdd:cd19124 223 EIAAAKGKTVAQVSLRWVYEQGVSLVVKSFNKERMKQNLDIFdwELTEEDLE 274
|
|
| AKR_AKR1D1-3 |
cd19109 |
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ... |
30-322 |
1.17e-61 |
|
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.
Pssm-ID: 381335 [Multi-domain] Cd Length: 308 Bit Score: 199.26 E-value: 1.17e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 30 GVRIPALGLGTANPHEK--LAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLEDGSIKREDLFITTKVW----- 102
Cdd:cd19109 1 GNSIPIIGLGTYSEPKTtpKGACAEAVKVAIDTGYRHIDGAYIYQNEHEVGQAIREKIAEGKVKREDIFYCGKLWntchp 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 103 PVLwdeVDRSLNESLKALGLEYVDLLLQHWPLCFEkikdpkgiSGLVKTPVDDSGKTMYaADGDYLETYKQLEKIyldPN 182
Cdd:cd19109 81 PEL---VRPTLERTLKVLQLDYVDLYIIEMPMAFK--------PGDEIYPRDENGKWLY-HKTNLCATWEALEAC---KD 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 183 DHRVRAIGVSNFSIEYLERLIKE--CRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGA---------PNL 251
Cdd:cd19109 146 AGLVKSIGVSNFNRRQLELILNKpgLKHKPVSNQVECHPYFTQPKLLEFCQQHDIVIVAYSPLGTCRDpiwvnvsspPLL 225
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398365091 252 KIPLVKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEF--ASLTKDELQELNDFGEKypVRFID 322
Cdd:cd19109 226 EDPLLNSIGKKYNKTAAQVVLRFNIQRGVVVIPKSFNPERIKENFQIfdFSLTEEEMKDIEALNKN--VRYVE 296
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
27-309 |
8.52e-61 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 196.06 E-value: 8.52e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 27 LNNGVRIPALGLG---TANPheklaETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKElledGSIKREDLFITTKVWP 103
Cdd:PRK11565 9 LQDGNVMPQLGLGvwqASNE-----EVITAIHKALEVGYRSIDTAAIYKNEEGVGKALKE----ASVAREELFITTKLWN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 104 VLWDEVDRSLNESLKALGLEYVDLLLQHWPLcfekikdpkgisglvktPVDDSgktmyaadgdYLETYKQLekIYLDpND 183
Cdd:PRK11565 80 DDHKRPREALEESLKKLQLDYVDLYLMHWPV-----------------PAIDH----------YVEAWKGM--IELQ-KE 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 184 HRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGAPNLKIPLVKKLAEKY 263
Cdd:PRK11565 130 GLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGKGVFDQKVIRDLADKY 209
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 398365091 264 NVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIE---FaSLTKDELQEL 309
Cdd:PRK11565 210 GKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDvfdF-RLDKDELGEI 257
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
29-310 |
1.18e-60 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 194.78 E-value: 1.18e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 29 NGVRIPALGLGT-ANPHEKLAEtkqAVKAAIKAGYRHIDTAWAYETEPFVGEAIKelleDGSIKREDLFITTKVWPVLWD 107
Cdd:cd19140 4 NGVRIPALGLGTyPLTGEECTR---AVEHALELGYRHIDTAQMYGNEAQVGEAIA----ASGVPRDELFLTTKVWPDNYS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 108 EVD--RSLNESLKALGLEYVDLLLQHWPlcfekikdpkgisglvktpvddsgktmyAADGDYLETYKQLEKIYldpNDHR 185
Cdd:cd19140 77 PDDflASVEESLRKLRTDYVDLLLLHWP----------------------------NKDVPLAETLGALNEAQ---EAGL 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 186 VRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGApnLKIPLVKKLAEKYNV 265
Cdd:cd19140 126 ARHIGVSNFTVALLREAVELSEAPLFTNQVEYHPYLDQRKLLDAAREHGIALTAYSPLARGEV--LKDPVLQEIGRKHGK 203
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 398365091 266 TGNDLLISYHIRQ-GTIVIPRSLNPVRISSSIE---FaSLTKDELQELN 310
Cdd:cd19140 204 TPAQVALRWLLQQeGVAAIPKATNPERLEENLDifdF-TLSDEEMARIA 251
|
|
| AKR_AKR2A1-2 |
cd19112 |
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ... |
25-316 |
1.72e-57 |
|
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.
Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 188.46 E-value: 1.72e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 25 FSLNNGVRIPALGLGT--ANPHEklaeTKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLEDGSIKREDLFITTKVW 102
Cdd:cd19112 3 ITLNSGHKMPVIGLGVwrMEPGE----IKELILNAIKIGYRHFDCAADYKNEKEVGEALAEAFKTGLVKREDLFITTKLW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 103 PVLWDEVDRSLNESLKALGLEYVDLLLQHWPLCFEKikdpKGIsGLVKTPVDDSGKTMYAADGDYLETYKQLEKIYldpN 182
Cdd:cd19112 79 NSDHGHVIEACKDSLKKLQLDYLDLYLVHFPVATKH----TGV-GTTGSALGEDGVLDIDVTISLETTWHAMEKLV---S 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 183 DHRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGShGAPN---------LKI 253
Cdd:cd19112 151 AGLVRSIGISNYDIFLTRDCLAYSKIKPAVNQIETHPYFQRDSLVKFCQKHGISVTAHTPLGG-AAANaewfgsvspLDD 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 398365091 254 PLVKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFA--SLTKDELQELNDFGEKY 316
Cdd:cd19112 230 PVLKDLAKKYGKSAAQIVLRWGIQRNTAVIPKSSKPERLKENIDVFdfQLSKEDMKLIKSLDRKY 294
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
27-316 |
3.57e-55 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 181.21 E-value: 3.57e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 27 LNNGVRIPALGLGTANPHEklAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKElledGSIKREDLFITTKVWP--V 104
Cdd:cd19134 5 LNDDNTMPVIGLGVGELSD--DEAERSVSAALEAGYRLIDTAAAYGNEAAVGRAIAA----SGIPRGELFVTTKLATpdQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 105 LWDEVDRSLNESLKALGLEYVDLLLQHWPLcfekikdpkgisglvktpvddsgktmyAADGDYLETYKQLEKIyldPNDH 184
Cdd:cd19134 79 GFTASQAACRASLERLGLDYVDLYLIHWPA---------------------------GREGKYVDSWGGLMKL---REEG 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 185 RVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGsHGAPnLKIPLVKKLAEKYN 264
Cdd:cd19134 129 LARSIGVSNFTAEHLENLIDLTFFTPAVNQIELHPLLNQAELRKVNAQHGIVTQAYSPLG-VGRL-LDNPAVTAIAAAHG 206
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 398365091 265 VTGNDLLISYHIRQGTIVIPRSLNPVRISSSI---EFaSLTKDELQELN--DFGEKY 316
Cdd:cd19134 207 RTPAQVLLRWSLQLGNVVISRSSNPERIASNLdvfDF-ELTADHMDALDglDDGTRF 262
|
|
| AKR_AKR2B1-10 |
cd19113 |
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ... |
24-309 |
1.41e-54 |
|
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.
Pssm-ID: 381339 [Multi-domain] Cd Length: 310 Bit Score: 181.10 E-value: 1.41e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 24 YFSLNNGVRIPALGLGTAN-PHEKLAETkqaVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLEDGSIKREDLFITTKVW 102
Cdd:cd19113 2 DIKLNSGYKMPSVGFGCWKlDNATAADQ---IYQAIKAGYRLFDGAEDYGNEKEVGEGVNRAIDEGLVKREELFLTSKLW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 103 -----PvlwDEVDRSLNESLKALGLEYVDLLLQHWPLCFEKI----KDPKGisglvktpvddsgktMYAADGD------- 166
Cdd:cd19113 79 nnfhdP---KNVETALNKTLSDLKLDYVDLFLIHFPIAFKFVpieeKYPPG---------------FYCGDGDnfvyedv 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 167 -YLETYKQLEKIYldpNDHRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGS 245
Cdd:cd19113 141 pILDTWKALEKLV---DAGKIKSIGVSNFPGALILDLLRGATIKPAVLQIEHHPYLQQPKLIEYAQKAGITITAYSSFGP 217
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 398365091 246 HGAPNLKIPL------------VKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFAS--LTKDELQEL 309
Cdd:cd19113 218 QSFVELNQGRalntptlfehdtIKSIAAKHNKTPAQVLLRWATQRGIAVIPKSNLPERLLQNLSVNDfdLTKEDFEEI 295
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
27-306 |
3.72e-54 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 178.18 E-value: 3.72e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 27 LNNGVRIPALGLGTANPHEklAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKElledGSIKREDLFITTKVW---- 102
Cdd:cd19130 4 LNDGNSIPQLGYGVFKVPP--ADTQRAVATALEVGYRHIDTAAIYGNEEGVGAAIAA----SGIPRDELFVTTKLWndrh 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 103 -PvlwDEVDRSLNESLKALGLEYVDLLLQHWPLcfekikdpkgisglvktpvddsgktmyAADGDYLETYKQLEKIYldp 181
Cdd:cd19130 78 dG---DEPAAAFAESLAKLGLDQVDLYLVHWPT---------------------------PAAGNYVHTWEAMIELR--- 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 182 NDHRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGShgAPNLKIPLVKKLAE 261
Cdd:cd19130 125 AAGRTRSIGVSNFLPPHLERIVAATGVVPAVNQIELHPAYQQRTIRDWAQAHDVKIEAWSPLGQ--GKLLGDPPVGAIAA 202
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 398365091 262 KYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIE---FAsLTKDEL 306
Cdd:cd19130 203 AHGKTPAQIVLRWHLQKGHVVFPKSVRRERMEDNLDvfdFD-LTDTEI 249
|
|
| AKR_AKR2C1 |
cd19114 |
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ... |
30-305 |
8.35e-52 |
|
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.
Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 173.51 E-value: 8.35e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 30 GVRIPALGLGTANPHEKlaETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLEDGSIKREDLFITTKVWPVLW--D 107
Cdd:cd19114 1 GDKMPLVGFGTAKIKAN--ETEEVIYNAIKVGYRLIDGALLYGNEAEVGRGIRKAIQEGLVKREDLFIVTKLWNNFHgkD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 108 EVDRSLNESLKALGLEYVDLLLQHWPLCFEKIkDPKgisgLVKTPV--DDSGKTMYAADGDYLETYKQLEKIYldpNDHR 185
Cdd:cd19114 79 HVREAFDRQLKDYGLDYIDLYLIHFPIPAAYV-DPA----ENYPFLwkDKELKKFPLEQSPMQECWREMEKLV---DAGL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 186 VRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGS-----------HGAPNLKIP 254
Cdd:cd19114 151 VRNIGIANFNVQLILDLLTYAKIKPAVLQIEHHPYLQQKRLIDWAKKQGIQITAYSSFGNavytkvtkhlkHFTNLLEHP 230
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 398365091 255 LVKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFASLTKDE 305
Cdd:cd19114 231 VVKKLADKHKRDTGQVLLRWAVQRNITVIPKSVNVERMKTNLDITSYKLDE 281
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
33-309 |
5.74e-48 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 162.14 E-value: 5.74e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 33 IPALGLGTANphEKLAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKElledGSIKREDLFITTKVWP--VLWDEVD 110
Cdd:cd19139 1 IPAFGLGTFR--LKDDVVIDSVRTALELGYRHIDTAQIYDNEAAVGQAIAE----SGVPRDELFITTKIWIdnLSKDKLL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 111 RSLNESLKALGLEYVDLLLQHWPlcfekikdpkGISGLVktPVddsgktmyaadGDYLETYKQLEKIYLdpndhrVRAIG 190
Cdd:cd19139 75 PSLEESLEKLRTDYVDLTLIHWP----------SPNDEV--PV-----------EEYIGALAEAKEQGL------TRHIG 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 191 VSNFSIEYLERLIKECRVKP-TVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGApnLKIPLVKKLAEKYNVTGND 269
Cdd:cd19139 126 VSNFTIALLDEAIAVVGAGAiATNQIELSPYLQNRKLVAHCKQHGIHVTSYMTLAYGKV--LDDPVLAAIAERHGATPAQ 203
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 398365091 270 LLISYHIRQGTIVIPRSLNPVRISSSIEFAS--LTKDELQEL 309
Cdd:cd19139 204 IALAWAMARGYAVIPSSTKREHLRSNLLALDltLDADDMAAI 245
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
30-310 |
2.31e-47 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 160.86 E-value: 2.31e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 30 GVRIPALGLGT----ANPHEKLAETKQAVKA---AIKAGYRHIDTAWAY---ETEPFVGEAIKELledgsiKREDLFITT 99
Cdd:cd19072 1 GEEVPVLGLGTwgigGGMSKDYSDDKKAIEAlryAIELGINLIDTAEMYgggHAEELVGKAIKGF------DREDLFITT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 100 KVWPV--LWDEVDRSLNESLKALGLEYVDLLLQHWPLCFEKIKdpkgisglvktpvddsgktmyaadgdylETYKQLEKI 177
Cdd:cd19072 75 KVSPDhlKYDDVIKAAKESLKRLGTDYIDLYLIHWPNPSIPIE----------------------------ETLRAMEEL 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 178 YldpNDHRVRAIGVSNFSIEYLERLIKE-CRVKPTVNQVE---THPHlPQMELRKFCFMHDILLTAYSPLGSHGAPNLK- 252
Cdd:cd19072 127 V---EEGKIRYIGVSNFSLEELEEAQSYlKKGPIVANQVEynlFDRE-EESGLLPYCQKNGIAIIAYSPLEKGKLSNAKg 202
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 398365091 253 IPLVKKLAEKYNVTGNDLLISYHIRQ-GTIVIPRSLNP---VRISSSIEFaSLTKDELQELN 310
Cdd:cd19072 203 SPLLDEIAKKYGKTPAQIALNWLISKpNVIAIPKASNIehlEENAGALGW-ELSEEDLQRLD 263
|
|
| AKR_AKR2D1 |
cd19115 |
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ... |
27-311 |
1.52e-45 |
|
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.
Pssm-ID: 381341 [Multi-domain] Cd Length: 311 Bit Score: 157.58 E-value: 1.52e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 27 LNNGVRIPALGLGTAN-PHEKLAETkqaVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLEDGSIKREDLFITTKVWPVL 105
Cdd:cd19115 7 LNSGYDMPLVGFGLWKvNNDTCADQ---VYNAIKAGYRLFDGACDYGNEVEAGQGVARAIKEGIVKREDLFIVSKLWNTF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 106 WDE--VDRSLNESLKALGLEYVDLLLQHWPLCFEKIkDPKgisglVKTPVD--DSGKTMYAADGDYLETYKQLEKIYldp 181
Cdd:cd19115 84 HDGerVEPICRKQLADWGIDYFDLFLIHFPIALKYV-DPA-----VRYPPGwfYDGKKVEFSNAPIQETWTAMEKLV--- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 182 NDHRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHG------------AP 249
Cdd:cd19115 155 DKGLARSIGVSNFSAQLLMDLLRYARIRPATLQIEHHPYLTQPRLVKYAQKEGIAVTAYSSFGPQSfleldlpgakdtPP 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398365091 250 NLKIPLVKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFAS--LTKDELQELND 311
Cdd:cd19115 235 LFEHDVIKSIAEKHGKTPAQVLLRWATQRGIAVIPKSNNPKRLAQNLDVTGfdLEAEEIKAISA 298
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
36-309 |
4.94e-44 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 152.85 E-value: 4.94e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 36 LGLGTA---NPHEKL--AETKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKELLEdgsiKREDLFITTKVWPVL-- 105
Cdd:pfam00248 1 IGLGTWqlgGGWGPIskEEALEALRAALEAGINFIDTAEVYgdgKSEELLGEALKDYPV----KRDKVVIATKVPDGDgp 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 106 ------WDEVDRSLNESLKALGLEYVDLLLQHWPlcfekikDPkgisglvktpvddsgktmyaaDGDYLETYKQLEKIYL 179
Cdd:pfam00248 77 wpsggsKENIRKSLEESLKRLGTDYIDLYYLHWP-------DP---------------------DTPIEETWDALEELKK 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 180 dpnDHRVRAIGVSNFSIEYLERLIKECRVKPTVNQVETHP--HLPQMELRKFCFMHDILLTAYSPLGS------------ 245
Cdd:pfam00248 129 ---EGKIRAIGVSNFDAEQIEKALTKGKIPIVAVQVEYNLlrRRQEEELLEYCKKNGIPLIAYSPLGGglltgkytrdpd 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 246 ----HGAPNLK---------IPLVKKLAEKYNVTGNDLLISYHIRQ--GTIVIPRSLNPVRISSSIEFAS--LTKDELQE 308
Cdd:pfam00248 206 kgpgERRRLLKkgtplnleaLEALEEIAKEHGVSPAQVALRWALSKpgVTIPIPGASNPEQLEDNLGALEfpLSDEEVAR 285
|
.
gi 398365091 309 L 309
Cdd:pfam00248 286 I 286
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
26-310 |
1.42e-41 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 145.85 E-value: 1.42e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 26 SLNNGVRIPALGLGT---ANPHEKLAETKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKELledgsikREDLFITT 99
Cdd:cd19138 4 TLPDGTKVPALGQGTwymGEDPAKRAQEIEALRAGIDLGMTLIDTAEMYgdgGSEELVGEAIRGR-------RDKVFLVS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 100 KVWPvlW----DEVDRSLNESLKALGLEYVDLLLQHW----PL-----CFEKIKdpkgisglvktpvdDSGKtmyaadgd 166
Cdd:cd19138 77 KVLP--SnasrQGTVRACERSLRRLGTDYLDLYLLHWrggvPLaetvaAMEELK--------------KEGK-------- 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 167 yletykqlekiyldpndhrVRAIGVSNFSIEYLERLI-----KECrvkpTVNQVEThpHLPQ----MELRKFCFMHDILL 237
Cdd:cd19138 133 -------------------IRAWGVSNFDTDDMEELWavpggGNC----AANQVLY--NLGSrgieYDLLPWCREHGVPV 187
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 398365091 238 TAYSPLGSHGAPN---LKIPLVKKLAEKYNVTGNDLLISYHIRQG-TIVIPRSLNPVRISSSIEFAS--LTKDELQELN 310
Cdd:cd19138 188 MAYSPLAQGGLLRrglLENPTLKEIAARHGATPAQVALAWVLRDGnVIAIPKSGSPEHARENAAAADleLTEEDLAELD 266
|
|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
33-286 |
4.47e-39 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 139.39 E-value: 4.47e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 33 IPALGLGTANPHEKLAETkqAVKAAIKAGYRHIDTAWAYETEPFVGEAIKElledGSIKREDLFITTKVWpvlwdeVDR- 111
Cdd:PRK11172 3 IPAFGLGTFRLKDQVVID--SVKTALELGYRAIDTAQIYDNEAAVGQAIAE----SGVPRDELFITTKIW------IDNl 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 112 -------SLNESLKALGLEYVDLLLQHWPlcfekikDPKGisglvKTPVDdsgktmyaadgDYLETYKQLEKIYLdpndh 184
Cdd:PRK11172 71 akdklipSLKESLQKLRTDYVDLTLIHWP-------SPND-----EVSVE-----------EFMQALLEAKKQGL----- 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 185 rVRAIGVSNFSIEYLERLIKECRVKP-TVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGApnLKIPLVKKLAEKY 263
Cdd:PRK11172 123 -TREIGISNFTIALMKQAIAAVGAENiATNQIELSPYLQNRKVVAFAKEHGIHVTSYMTLAYGKV--LKDPVIARIAAKH 199
|
250 260
....*....|....*....|...
gi 398365091 264 NVTGNDLLISYHIRQGTIVIPRS 286
Cdd:PRK11172 200 NATPAQVILAWAMQLGYSVIPSS 222
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
30-310 |
8.55e-39 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 138.47 E-value: 8.55e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 30 GVRIPALGLGT-------ANPHEKLAETKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKELledgsiKREDLFITT 99
Cdd:cd19137 1 GEKIPALGLGTwgiggflTPDYSRDEEMVELLKTAIELGYTHIDTAEMYgggHTEELVGKAIKDF------PREDLFIVT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 100 KVWP--VLWDEVDRSLNESLKALGLEYVDLLLQHWPlcfekikDPkgisglvKTPVDdsgktmyaadgdylETYKQLEKI 177
Cdd:cd19137 75 KVWPtnLRYDDLLRSLQNSLRRLDTDYIDLYLIHWP-------NP-------NIPLE--------------ETLSAMAEG 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 178 YldpNDHRVRAIGVSNFSIEYLERLIKECRVKPTVNQVE--THPHLPQME-LRKFCFMHDILLTAYSPLGSHGAPnlKIP 254
Cdd:cd19137 127 V---RQGLIRYIGVSNFNRRLLEEAISKSQTPIVCNQVKynLEDRDPERDgLLEYCQKNGITVVAYSPLRRGLEK--TNR 201
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 398365091 255 LVKKLAEKYNVTGNDLLISYHIRQGTIV-IPRSLNPVRISSSIEFA--SLTKDELQELN 310
Cdd:cd19137 202 TLEEIAKNYGKTIAQIALAWLIQKPNVVaIPKAGRVEHLKENLKATeiKLSEEEMKLLD 260
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
32-310 |
3.63e-34 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 126.96 E-value: 3.63e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 32 RIPALGLGT---------ANPHEKLAETKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKELLEdgsikREDLFITT 99
Cdd:cd19093 1 EVSPLGLGTwqwgdrlwwGYGEYGDEDLQAAFDAALEAGVNLFDTAEVYgtgRSERLLGRFLKELGD-----RDEVVIAT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 100 KVWPVLW----DEVDRSLNESLKALGLEYVDLLLQHWPLCFekikdpkgisglvktpvddsgktmYAADGDYLETykqLE 175
Cdd:cd19093 76 KFAPLPWrltrRSVVKALKASLERLGLDSIDLYQLHWPGPW------------------------YSQIEALMDG---LA 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 176 KIYldpNDHRVRAIGVSNFSIEYLER---LIKECRVKPTVNQVE---THPHLPQMELRKFCFMHDILLTAYSPL------ 243
Cdd:cd19093 129 DAV---EEGLVRAVGVSNYSADQLRRahkALKERGVPLASNQVEyslLYRDPEQNGLLPACDELGITLIAYSPLaqgllt 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 244 GSHGAPNL---------------KI-PLVKKL---AEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRIsssIEFA----- 299
Cdd:cd19093 206 GKYSPENPppggrrrlfgrknleKVqPLLDALeeiAEKYGKTPAQVALNWLIAKGVVPIPGAKNAEQA---EENAgalgw 282
|
330
....*....|.
gi 398365091 300 SLTKDELQELN 310
Cdd:cd19093 283 RLSEEEVAELD 293
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
34-251 |
1.19e-32 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 121.47 E-value: 1.19e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 34 PALGLGTAN--PHEKLAETKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKElledgSIKREDLFITTKV-WPVLWD 107
Cdd:cd06660 1 SRLGLGTMTfgGDGDEEEAFALLDAALEAGGNFFDTADVYgdgRSERLLGRWLKG-----RGNRDDVVIATKGgHPPGGD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 108 EVD---------RSLNESLKALGLEYVDLLLQHWPlcfekikDPkgisglvKTPVDDsgkTMyaadgDYLETYKQLEKIy 178
Cdd:cd06660 76 PSRsrlspehirRDLEESLRRLGTDYIDLYYLHRD-------DP-------STPVEE---TL-----EALNELVREGKI- 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 179 ldpndhrvRAIGVSNFSIEYLERLIKECR----VKPTVNQVE---THPHLPQMELRKFCFMHDILLTAYSPLGShGAPNL 251
Cdd:cd06660 133 --------RYIGVSNWSAERLAEALAYAKahglPGFAAVQPQyslLDRSPMEEELLDWAEENGLPLLAYSPLAR-GPAQL 203
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
28-317 |
1.29e-32 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 123.36 E-value: 1.29e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 28 NNGVRIPALGLGTAN---PHEKL--AETKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKELledgsiKREDLFITT 99
Cdd:COG0667 8 RSGLKVSRLGLGTMTfggPWGGVdeAEAIAILDAALDAGINFFDTADVYgpgRSEELLGEALKGR------PRDDVVIAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 100 KVWPVLWDEVD----------RSLNESLKALGLEYVDLLLQHWPlcfekikDPkgisglvKTPVDDsgkTMYAadgdyLE 169
Cdd:COG0667 82 KVGRRMGPGPNgrglsrehirRAVEASLRRLGTDYIDLYQLHRP-------DP-------DTPIEE---TLGA-----LD 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 170 TYKQlekiyldpnDHRVRAIGVSNFSIEYLERLIKECR--VKPTVNQVETHP--HLPQMELRKFCFMHDILLTAYSPL-- 243
Cdd:COG0667 140 ELVR---------EGKIRYIGVSNYSAEQLRRALAIAEglPPIVAVQNEYSLldRSAEEELLPAARELGVGVLAYSPLag 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 244 ---------------GSHGAPNL-----------KIPLVKKLAEKYNVTGNDLLISYHIRQG--TIVIP--RSLNpvRIS 293
Cdd:COG0667 211 glltgkyrrgatfpeGDRAATNFvqgylternlaLVDALRAIAAEHGVTPAQLALAWLLAQPgvTSVIPgaRSPE--QLE 288
|
330 340
....*....|....*....|....*.
gi 398365091 294 SSIEFAS--LTKDELQELNDFGEKYP 317
Cdd:COG0667 289 ENLAAADleLSAEDLAALDAALAAVP 314
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
33-311 |
1.35e-29 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 114.99 E-value: 1.35e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 33 IPALGLGTAN-------PHEKLAETKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKElledgsiKREDLFITTKVW 102
Cdd:cd19085 1 VSRLGLGCWQfgggywwGDQDDEESIATIHAALDAGINFFDTAEAYgdgHSEEVLGKALKG-------RRDDVVIATKVS 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 103 P--VLWDEVDRSLNESLKALGLEYVDLLLQHWPLCFEkikdpkgisglvktpvdDSGKTMYAadgdyLETYKQLEKIyld 180
Cdd:cd19085 74 PdnLTPEDVRKSCERSLKRLGTDYIDLYQIHWPSSDV-----------------PLEETMEA-----LEKLKEEGKI--- 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 181 pndhrvRAIGVSNFSIEYLERLIKECRVkpTVNQ---------VEThphlpqmELRKFCFMHDILLTAYSPLGS------ 245
Cdd:cd19085 129 ------RAIGVSNFGPAQLEEALDAGRI--DSNQlpynllwraIEY-------EILPFCREHGIGVLAYSPLAQglltgk 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 246 ------------------HGAPNLK------IPLVKKLAEKYNVTGNDLLISYHIRQGTI--VIPRSLNPVRISSSIEFA 299
Cdd:cd19085 194 fssaedfppgdartrlfrHFEPGAEeetfeaLEKLKEIADELGVTMAQLALAWVLQQPGVtsVIVGARNPEQLEENAAAV 273
|
330
....*....|....
gi 398365091 300 S--LTKDELQELND 311
Cdd:cd19085 274 DleLSPSVLERLDE 287
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
30-310 |
7.93e-28 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 109.92 E-value: 7.93e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 30 GVRIPALGLGTAN------PHEKLAETKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKElledgsiKREDLFITTK 100
Cdd:cd19084 1 DLKVSRIGLGTWAiggtwwGEVDDQESIEAIKAAIDLGINFFDTAPVYgfgHSEEILGKALKG-------RRDDVVIATK 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 101 VwPVLWDE------------VDRSLNESLKALGLEYVDLLLQHWPlcfekikDPkgisglvKTPVDDsgkTMYAadgdyL 168
Cdd:cd19084 74 C-GLRWDGgkgvtkdlspesIRKEVEQSLRRLQTDYIDLYQIHWP-------DP-------NTPIEE---TAEA-----L 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 169 ETYKQLEKIyldpndhrvRAIGVSNFSIEYLERLIKECRVkpTVNQVETHPHLPQME--LRKFCFMHDILLTAYSPLGsH 246
Cdd:cd19084 131 EKLKKEGKI---------RYIGVSNFSVEQLEEARKYGPI--VSLQPPYSMLEREIEeeLLPYCRENGIGVLPYGPLA-Q 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 247 G-----------------------------APNLKI-PLVKKLAEKYNVTGNDLLISYHIRQ--GTIVIPRSLNPVRISS 294
Cdd:cd19084 199 GlltgkykkeptfppddrrsrfpffrgenfEKNLEIvDKLKEIAEKYGKSLAQLAIAWTLAQpgVTSAIVGAKNPEQLEE 278
|
330
....*....|....*...
gi 398365091 295 SIEFA--SLTKDELQELN 310
Cdd:cd19084 279 NAGALdwELTEEELKEID 296
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
30-204 |
8.71e-22 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 92.16 E-value: 8.71e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 30 GVRIPALGLGTA-NPHEKLAETKQAVKAAIKAGYRHIDTAWAY-ETEPFVGEAIKElledgsiKREDLFITTKVWPVLWD 107
Cdd:cd19100 8 GLKVSRLGFGGGpLGRLSQEEAAAIIRRALDLGINYFDTAPSYgDSEEKIGKALKG-------RRDKVFLATKTGARDYE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 108 EVDRSLNESLKALGLEYVDLLLQHwplCfekikdpkgisglVKTPvDDSGKTMyAADG--DYLETYKQlEKIyldpndhr 185
Cdd:cd19100 81 GAKRDLERSLKRLGTDYIDLYQLH---A-------------VDTE-EDLDQVF-GPGGalEALLEAKE-EGK-------- 133
|
170
....*....|....*....
gi 398365091 186 VRAIGVSNFSIEYLERLIK 204
Cdd:cd19100 134 IRFIGISGHSPEVLLRALE 152
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
28-145 |
1.41e-21 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 94.12 E-value: 1.41e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 28 NNGVRIPALGLGT----ANPHEKLAETkqaVKAAIKAGYRHIDTAWAY-ETEPFVGEAIKELledgsikREDLFITTKVW 102
Cdd:COG1453 8 KTGLEVSVLGFGGmrlpRKDEEEAEAL---IRRAIDNGINYIDTARGYgDSEEFLGKALKGP-------RDKVILATKLP 77
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 398365091 103 PVLWD--EVDRSLNESLKALGLEYVDLLLQH---WPLCFEKIKDPKGI 145
Cdd:COG1453 78 PWVRDpeDMRKDLEESLKRLQTDYIDLYLIHglnTEEDLEKVLKPGGA 125
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
33-245 |
1.15e-19 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 87.73 E-value: 1.15e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 33 IPALGLGT---ANPHEKLAETKQ-------AVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKELledgsikREDLFITT 99
Cdd:cd19102 1 LTTIGLGTwaiGGGGWGGGWGPQddrdsiaAIRAALDLGINWIDTAAVYglgHSEEVVGRALKGL-------RDRPIVAT 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 100 KVWPvLWDE------------VDRSLNESLKALGLEYVDLLLQHWPLCFEKIKDP-KGISGLVKtpvddSGKtmyaadgd 166
Cdd:cd19102 74 KCGL-LWDEegrirrslkpasIRAECEASLRRLGVDVIDLYQIHWPDPDEPIEEAwGALAELKE-----EGK-------- 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 167 yletykqlekiyldpndhrVRAIGVSNFSIEYLERLIKecrVKP-TVNQVE---THPHLPQmELRKFCFMHDILLTAYSP 242
Cdd:cd19102 140 -------------------VRAIGVSNFSVDQMKRCQA---IHPiASLQPPyslLRRGIEA-EILPFCAEHGIGVIVYSP 196
|
...
gi 398365091 243 LGS 245
Cdd:cd19102 197 MQS 199
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
28-305 |
7.22e-19 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 85.30 E-value: 7.22e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 28 NNGVRIPALGLGTANPHEKLAETKQA---VKAAIKAGYRHIDTA---WAYETEPFVGEAIKElledGSIKREDLFITTKV 101
Cdd:cd19092 1 PEGLEVSRLVLGCMRLADWGESAEELlslIEAALELGITTFDHAdiyGGGKCEELFGEALAL----NPGLREKIEIQTKC 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 102 WPVLWDE---------------VDRSLNESLKALGLEYVDLLLQHWPlcfekikDPkgisgLVktpvddsgktmyaadgD 166
Cdd:cd19092 77 GIRLGDDprpgrikhydtskehILASVEGSLKRLGTDYLDLLLLHRP-------DP-----LM----------------D 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 167 YLETYKQLEKIYldpNDHRVRAIGVSNFSIEYLERLIKECRVKPTVNQVE---THPHLPQMELRKFCFMHDILLTAYSPL 243
Cdd:cd19092 129 PEEVAEAFDELV---KSGKVRYFGVSNFTPSQIELLQSYLDQPLVTNQIElslLHTEAIDDGTLDYCQLLDITPMAWSPL 205
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398365091 244 G--------SHGAPNLKIpLVKKLAEKYNVTGNDLLISYHIRQ--GTIVIPRSLNPVRISSSIEFAS--LTKDE 305
Cdd:cd19092 206 GggrlfggfDERFQRLRA-ALEELAEEYGVTIEAIALAWLLRHpaRIQPILGTTNPERIRSAVKALDieLTREE 278
|
|
| YdhF |
COG4989 |
Predicted oxidoreductase YdhF [General function prediction only]; |
37-297 |
9.97e-19 |
|
Predicted oxidoreductase YdhF [General function prediction only];
Pssm-ID: 444013 [Multi-domain] Cd Length: 299 Bit Score: 85.20 E-value: 9.97e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 37 GLGTANPHEKLAETKqaVKAAIKAGYRHIDTA---WAYETEPFVGEAIKELledgSIKREDLFITTKVWPVLWDEVD--- 110
Cdd:COG4989 22 RLGEWDLSPAEAAAL--IEAALELGITTFDHAdiyGGYTCEALFGEALKLS----PSLREKIELQTKCGIRLPSEARdnr 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 111 ------------RSLNESLKALGLEYVDLLLQHWPlcfekikDP--------KGISGLVKtpvddSGKtmyaadgdylet 170
Cdd:COG4989 96 vkhydtskehiiASVEGSLRRLGTDYLDLLLLHRP-------DPlmdpeevaEAFDELKA-----SGK------------ 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 171 ykqlekiyldpndhrVRAIGVSNFS---IEYLErliKECRVKPTVNQVETHP-HLPQME--LRKFCFMHDILLTAYSPLG 244
Cdd:COG4989 152 ---------------VRHFGVSNFTpsqFELLQ---SALDQPLVTNQIELSLlHTDAFDdgTLDYCQLNGITPMAWSPLA 213
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 398365091 245 SH---GAPNLKIP----LVKKLAEKYNVTGNDLLISYHIRQ--GTIVIPRSLNPVRISSSIE 297
Cdd:COG4989 214 GGrlfGGFDEQFPrlraALDELAEKYGVSPEAIALAWLLRHpaGIQPVIGTTNPERIKAAAA 275
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
28-262 |
1.71e-18 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 83.40 E-value: 1.71e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 28 NNGVRIPALGLGTANPhekLAETKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKElledgsIKREDLFITTKVWPV 104
Cdd:cd19105 8 KTGLKVSRLGFGGGGL---PRESPELLRRALDLGINYFDTAEGYgngNSEEIIGEALKG------LRRDKVFLATKASPR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 105 LW----DEVDRSLNESLKALGLEYVDLLLQHwplcfekikdpkGISGLvktpvddsgkTMYAADGDYLETYKQLEKiyld 180
Cdd:cd19105 79 LDkkdkAELLKSVEESLKRLQTDYIDIYQLH------------GVDTP----------EERLLNEELLEALEKLKK---- 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 181 pnDHRVRAIGVS--NFSIEYLERLIKecrvkptvnqvethphlpqmelrKFCFmhDILLTAYSPLGSHGAPNlkiPLVKK 258
Cdd:cd19105 133 --EGKVRFIGFSthDNMAEVLQAAIE-----------------------SGWF--DVIMVAYNFLNQPAELE---EALAA 182
|
....
gi 398365091 259 LAEK 262
Cdd:cd19105 183 AAEK 186
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
33-302 |
2.04e-18 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 83.42 E-value: 2.04e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 33 IPALGLGTAN--------PHEKLAETKQAVKAAIKAGYRHIDTAWAYetEPFVGEA-IKELLEDGSikrEDLFITTKV-- 101
Cdd:cd19088 1 VSRLGYGAMRltgpgiwgPPADREEAIAVLRRALELGVNFIDTADSY--GPDVNERlIAEALHPYP---DDVVIATKGgl 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 102 -------WPVLWD--EVDRSLNESLKALGLEYVDLLLQHWPlcfekikDPKGisglvktPVDDSgktmyaadgdyLETYK 172
Cdd:cd19088 76 vrtgpgwWGPDGSpeYLRQAVEASLRRLGLDRIDLYQLHRI-------DPKV-------PFEEQ-----------LGALA 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 173 QLEkiyldpNDHRVRAIGVSNFSIEYLERLIKECRVKPTVNQ---VETHPHlpqmELRKFCFMHDILLTAYSPLGSHG-A 248
Cdd:cd19088 131 ELQ------DEGLIRHIGLSNVTVAQIEEARAIVRIVSVQNRynlANRDDE----GVLDYCEAAGIAFIPWFPLGGGDlA 200
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 398365091 249 PNLkiPLVKKLAEKYNVTGNDLLISYHIRQG--TIVIPRSLNPVRISSSIEFASLT 302
Cdd:cd19088 201 QPG--GLLAEVAARLGATPAQVALAWLLARSpvMLPIPGTSSVEHLEENLAAAGLR 254
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
34-133 |
6.83e-18 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 82.22 E-value: 6.83e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 34 PALGLGTAN-----PHEKLAETKQAVKAAIKAGYRHIDTAWAY-ETEPFVGEAIKElledgsIKREDLFITTKVWPVLWD 107
Cdd:cd19090 1 SALGLGTAGlggvfGGVDDDEAVATIRAALDLGINYIDTAPAYgDSEERLGLALAE------LPREPLVLSTKVGRLPED 74
|
90 100 110
....*....|....*....|....*....|...
gi 398365091 108 EVD-------RSLNESLKALGLEYVDLLLQHWP 133
Cdd:cd19090 75 TADysadrvrRSVEESLERLGRDRIDLLMIHDP 107
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
30-243 |
1.81e-17 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 81.48 E-value: 1.81e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 30 GVRIPALGLGTANPHEKLAETKQA---VKAAIKAGYRHIDTAWAY---ETEPFVGEAIKELledgsiKREDLFITTKV-W 102
Cdd:cd19074 1 GLKVSELSLGTWLTFGGQVDDEDAkacVRKAYDLGINFFDTADVYaagQAEEVLGKALKGW------PRESYVISTKVfW 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 103 PVLWDEVDR---------SLNESLKALGLEYVDLLLQHWPlcfekikDPkgisglvKTPVDDSGKTMyaadgDYLetykq 173
Cdd:cd19074 75 PTGPGPNDRglsrkhifeSIHASLKRLQLDYVDIYYCHRY-------DP-------ETPLEETVRAM-----DDL----- 130
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 398365091 174 lekIyldpNDHRVRAIGVSNFSIEYLERLIKECR----VKPTVNQVETH----PHLPqmELRKFCFMHDILLTAYSPL 243
Cdd:cd19074 131 ---I----RQGKILYWGTSEWSAEQIAEAHDLARqfglIPPVVEQPQYNmlwrEIEE--EVIPLCEKNGIGLVVWSPL 199
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
34-150 |
1.99e-17 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 80.68 E-value: 1.99e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 34 PALGLGT------ANPHEKLAETKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKELledgsiKREDLFITTK--VW 102
Cdd:cd19096 1 SVLGFGTmrlpesDDDSIDEEKAIEMIRYAIDAGINYFDTAYGYgggKSEEILGEALKEG------PREKFYLATKlpPW 74
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 398365091 103 PVLW-DEVDRSLNESLKALGLEYVDLLLQHW---PLCFEKIKDPKGISGLVK 150
Cdd:cd19096 75 SVKSaEDFRRILEESLKRLGVDYIDFYLLHGlnsPEWLEKARKGGLLEFLEK 126
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
28-282 |
1.88e-16 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 78.85 E-value: 1.88e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 28 NNGVRIPALGLGT-------ANPHEKLAETKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKElledgsiKREDLFI 97
Cdd:cd19149 6 KSGIEASVIGLGTwaigggpWWGGSDDNESIRTIHAALDLGINLIDTAPAYgfgHSEEIVGKAIKG-------RRDKVVL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 98 TTK---VWPV-----LWDEVDRSLN-------------ESLKALGLEYVDLLLQHWPlcfekikdpkgisgLVKTPVDDs 156
Cdd:cd19149 79 ATKcglRWDReggsfFFVRDGVTVYknlspesireeveQSLKRLGTDYIDLYQTHWQ--------------DVETPIEE- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 157 gkTMYAadgdyLETYKQLEKIyldpndhrvRAIGVSNFSIEYLERLIKEcrVKPTVNQVETHPHLPQMELRKF--CFMHD 234
Cdd:cd19149 144 --TMEA-----LEELKRQGKI---------RAIGASNVSVEQIKEYVKA--GQLDIIQEKYSMLDRGIEKELLpyCKKNN 205
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 398365091 235 ILLTAYSPLG--------------SHGAPNLKIPLVKK---------------LAEKYNVTGNDLLISYHIRQGTIV 282
Cdd:cd19149 206 IAFQAYSPLEqglltgkitpdrefDAGDARSGIPWFSPenrekvlallekwkpLCEKYGCTLAQLVIAWTLAQPGIT 282
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
48-243 |
2.46e-16 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 78.12 E-value: 2.46e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 48 AETKQAVK---AAIKAGYRHIDTAWAY---ETEPFVGEAIKELLedgsiKREDLFITTKVwPVLWDEVD----------- 110
Cdd:cd19148 22 TDEKEAIEtihKALDLGINLIDTAPVYgfgLSEEIVGKALKEYG-----KRDRVVIATKV-GLEWDEGGevvrnsspari 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 111 -RSLNESLKALGLEYVDLLLQHWPlcfekikDPKgisglvkTPVDdsgktmyaadgdylETYKQLEKIYldpNDHRVRAI 189
Cdd:cd19148 96 rKEVEDSLRRLQTDYIDLYQVHWP-------DPL-------VPIE--------------ETAEALKELL---DEGKIRAI 144
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 190 GVSNFSIEYLERLIKECR---VKPTVNQVETH---PHLPqmelrkFCFMHDILLTAYSPL 243
Cdd:cd19148 145 GVSNFSPEQMETFRKVAPlhtVQPPYNLFEREiekDVLP------YARKHNIVTLAYGAL 198
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
34-204 |
4.66e-16 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 76.50 E-value: 4.66e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 34 PALGLGTANPHEK-----LAETKQAVKAAIKAGYRHIDTAWAY-ETEPFVGEAIKELLedgsikREDLFITTKVWPV--- 104
Cdd:cd19095 1 SVLGLGTSGIGRVwgvpsEAEAARLLNTALDLGINLIDTAPAYgRSEERLGRALAGLR------RDDLFIATKVGTHgeg 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 105 -----LW--DEVDRSLNESLKALGLEYVDLLLQHwplcfekikdpkgisglvKTPVDDSGKTMYAAdgdyLETYKQleki 177
Cdd:cd19095 75 grdrkDFspAAIRASIERSLRRLGTDYIDLLQLH------------------GPSDDELTGEVLET----LEDLKA---- 128
|
170 180
....*....|....*....|....*..
gi 398365091 178 yldpnDHRVRAIGVSNFSIEyLERLIK 204
Cdd:cd19095 129 -----AGKVRYIGVSGDGEE-LEAAIA 149
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
30-307 |
1.85e-15 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 75.92 E-value: 1.85e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 30 GVRIPALGLGTAN-------PHEKLAETKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKELledgsiKREDLFITT 99
Cdd:cd19083 8 DIDVNPIGLGTNAvgghnlyPNLDEEEGKDLVREALDNGVNLLDTAFIYglgRSEELVGEVLKEY------NRNEVVIAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 100 KvWPVLWDEVD-----------RSLNESLKALGLEYVDLLLQHWPlcfekikDPkgisglvKTPVDDSGKTmyaadgdyL 168
Cdd:cd19083 82 K-GAHKFGGDGsvlnnspeflrSAVEKSLKRLNTDYIDLYYIHFP-------DG-------ETPKAEAVGA--------L 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 169 ETYKQLEKIyldpndhrvRAIGVSNFSIEYLerliKECRVKPTVNQVETHPHLPQMELRK----FCFMHDILLTAYSPLG 244
Cdd:cd19083 139 QELKDEGKI---------RAIGVSNFSLEQL----KEANKDGYVDVLQGEYNLLQREAEEdilpYCVENNISFIPYFPLA 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 245 S-------------------------HGAP---NL-KIPLVKKLAEKYNVTGNDLLISYHIRQGTI--VIPRSLNPVRIS 293
Cdd:cd19083 206 SgllagkytkdtkfpdndlrndkplfKGERfseNLdKVDKLKSIADEKGVTVAHLALAWYLTRPAIdvVIPGAKRAEQVI 285
|
330
....*....|....*.
gi 398365091 294 SSIEFA--SLTKDELQ 307
Cdd:cd19083 286 DNLKALdvTLTEEEIA 301
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
37-245 |
8.26e-15 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 73.74 E-value: 8.26e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 37 GLGTANPHEKLAETKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKELledgsikrEDLFITTKVWPVL-----WDE 108
Cdd:cd19075 9 TFGSQGRFTTAEAAAELLDAFLERGHTEIDTARVYpdgTSEELLGELGLGE--------RGFKIDTKANPGVggglsPEN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 109 VDRSLNESLKALGLEYVDLLLQHWPlcfekikDPkgisglvKTPVDDsgkTMYAADgdylETYKQlekiyldpndHRVRA 188
Cdd:cd19075 81 VRKQLETSLKRLKVDKVDVFYLHAP-------DR-------STPLEE---TLAAID----ELYKE----------GKFKE 129
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398365091 189 IGVSNFSIEYLERLIKECR----VKPTVNQ---------VEThphlpqmEL----RKfcfmHDILLTAYSPLGS 245
Cdd:cd19075 130 FGLSNYSAWEVAEIVEICKengwVLPTVYQgmynaitrqVET-------ELfpclRK----LGIRFYAYSPLAG 192
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
28-318 |
6.07e-14 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 71.71 E-value: 6.07e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 28 NNGVRIPALGLGTA------NPHEKLAETKQAVKAAIKAGYRHIDTAWAY-ETEPFVGEAIKelLEDGsiKREDLFITTK 100
Cdd:cd19144 8 RNGPSVPALGFGAMglsafyGPPKPDEERFAVLDAAFELGCTFWDTADIYgDSEELIGRWFK--QNPG--KREKIFLATK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 101 V-------WPVLW-----DEVDRSLNESLKALGLEYVDLLLQHwplcfeKIkDPkgisglvKTPVDdsgKTMYAadgdyL 168
Cdd:cd19144 84 FgieknveTGEYSvdgspEYVKKACETSLKRLGVDYIDLYYQH------RV-DG-------KTPIE---KTVAA-----M 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 169 ETYKQLEKIyldpndhrvRAIGVSNFSIEYLERlikECRVKP-TVNQVETHPHL-----PQMELRKFCFMHDILLTAYSP 242
Cdd:cd19144 142 AELVQEGKI---------KHIGLSECSAETLRR---AHAVHPiAAVQIEYSPFSldierPEIGVLDTCRELGVAIVAYSP 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 243 L------GSHGAPN--------LKIP------------LV---KKLAEKYNVTGNDLLISYHIRQGT--IVIPRSLNPVR 291
Cdd:cd19144 210 LgrgfltGAIRSPDdfeegdfrRMAPrfqaenfpknleLVdkiKAIAKKKNVTAGQLTLAWLLAQGDdiIPIPGTTKLKR 289
|
330 340 350
....*....|....*....|....*....|.
gi 398365091 292 ISSSieFAS----LTKDELQELNDFGEKYPV 318
Cdd:cd19144 290 LEEN--LGAlkvkLTEEEEKEIREIAEEAEV 318
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
28-245 |
2.07e-13 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 69.92 E-value: 2.07e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 28 NNGVRIPALGLGTA---NPHEK-----LAETKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKELledgsIKREDLF 96
Cdd:cd19079 7 NSGLKVSRLCLGCMsfgDPKWRpwvldEEESRPIIKRALDLGINFFDTANVYsggASEEILGRALKEF-----APRDEVV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 97 ITTKVWPVLWDEVD----------RSLNESLKALGLEYVDLLLQHWPlcfekikDPkgisglvKTPVDDsgkTMYAADgD 166
Cdd:cd19079 82 IATKVYFPMGDGPNgrglsrkhimAEVDASLKRLGTDYIDLYQIHRW-------DY-------ETPIEE---TLEALH-D 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 167 YLETYKqlekiyldpndhrVRAIGVSNFS----IEYLERLIKECRVKPTVNQvethPHLPQM------ELRKFCFMHDIL 236
Cdd:cd19079 144 VVKSGK-------------VRYIGASSMYawqfAKALHLAEKNGWTKFVSMQ----NHYNLLyreeerEMIPLCEEEGIG 206
|
....*....
gi 398365091 237 LTAYSPLGS 245
Cdd:cd19079 207 VIPWSPLAR 215
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
28-284 |
2.24e-13 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 69.55 E-value: 2.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 28 NNGVRIPALGLGTANPHEKL-----AETKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKElledgsiKREDLFITT 99
Cdd:cd19076 7 TQGLEVSALGLGCMGMSAFYgpadeEESIATLHRALELGVTFLDTADMYgpgTNEELLGKALKD-------RRDEVVIAT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 100 KvWPVLWDE-------------VDRSLNESLKALGLEYVDLLLQHWPlcfekikDPkgisglvKTPVDDSGKTMyaadgd 166
Cdd:cd19076 80 K-FGIVRDPgsgfrgvdgrpeyVRAACEASLKRLGTDVIDLYYQHRV-------DP-------NVPIEETVGAM------ 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 167 yletyKQLEKiyldpnDHRVRAIGVSNFSIEYLERlikECRVKPtVNQVETHPHL----PQMELRKFCFMHDILLTAYSP 242
Cdd:cd19076 139 -----AELVE------EGKVRYIGLSEASADTIRR---AHAVHP-ITAVQSEYSLwtrdIEDEVLPTCRELGIGFVAYSP 203
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 398365091 243 LGsHG-----------------------------APNLKIPL-VKKLAEKYNVTGNDLLISYHIRQGTIVIP 284
Cdd:cd19076 204 LG-RGfltgaikspedlpeddfrrnnprfqgenfDKNLKLVEkLEAIAAEKGCTPAQLALAWVLAQGDDIVP 274
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
30-131 |
2.31e-13 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 69.99 E-value: 2.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 30 GVRIPALGLG---------TANPHEKLAetkqAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKELledgsikREDLFI 97
Cdd:cd19104 9 GLKVSELTFGgggigglmgRTTREEQIA----AVRRALDLGINFFDTAPSYgdgKSEENLGRALKGL-------PAGPYI 77
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 398365091 98 TTKV------WPVLWDEVDRSLNESLKALGLEYVDLLLQH 131
Cdd:cd19104 78 TTKVrldpddLGDIGGQIERSVEKSLKRLKRDSVDLLQLH 117
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
35-133 |
6.91e-13 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 68.50 E-value: 6.91e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 35 ALGLGTANPH---EKLAETKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKELLEDGSIKREDLFITTKV------- 101
Cdd:cd19099 5 SLGLGTYRGDsddETDEEYREALKAALDSGINVIDTAINYrggRSERLIGKALRELIEKGGIKRDEVVIVTKAgyipgdg 84
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 102 --------W--------PVLWDEVD------------RSLNESLKALGLEYVDLLLQHWP 133
Cdd:cd19099 85 deplrplkYleeklgrgLIDVADSAglrhcispayleDQIERSLKRLGLDTIDLYLLHNP 144
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
32-204 |
1.15e-12 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 66.73 E-value: 1.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 32 RIPALGLGT-------ANPHEKlAETKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKElledgsiKREDLFITTKV 101
Cdd:cd19086 2 EVSEIGFGTwglggdwWGDVDD-AEAIRALRAALDLGINFFDTADVYgdgHSERLLGKALKG-------RRDKVVIATKF 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 102 ---------WPVLW--DEVDRSLNESLKALGLEYVDLLLQH-WPLcfekikdpkgisglvktPVDDSGKTMyaadgDYLE 169
Cdd:cd19086 74 gnrfdggpeRPQDFspEYIREAVEASLKRLGTDYIDLYQLHnPPD-----------------EVLDNDELF-----EALE 131
|
170 180 190
....*....|....*....|....*....|....*
gi 398365091 170 TYKQLEKIyldpndhrvRAIGVSNFSIEYLERLIK 204
Cdd:cd19086 132 KLKQEGKI---------RAYGVSVGDPEEALAALR 157
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
28-244 |
1.98e-12 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 66.87 E-value: 1.98e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 28 NNGVRIPALGLGTANPHEK-----------LAETKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKElledgsiKRE 93
Cdd:cd19091 8 RSGLKVSELALGTMTFGGGggffgawggvdQEEADRLVDIALDAGINFFDTADVYsegESEEILGKALKG-------RRD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 94 DLFITTKVWPVLWDEVD----------RSLNESLKALGLEYVDLLLQHWPlcfekikDPkgisglvKTPVDDsgkTMYAA 163
Cdd:cd19091 81 DVLIATKVRGRMGEGPNdvglsrhhiiRAVEASLKRLGTDYIDLYQLHGF-------DA-------LTPLEE---TLRAL 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 164 DgDYLETYKqlekiyldpndhrVRAIGVSNFSIEYLERLIKECRVKPTVnQVETHphlpQM-----------ELRKFCFM 232
Cdd:cd19091 144 D-DLVRQGK-------------VRYIGVSNFSAWQIMKALGISERRGLA-RFVAL----QAyysllgrdlehELMPLALD 204
|
250
....*....|..
gi 398365091 233 HDILLTAYSPLG 244
Cdd:cd19091 205 QGVGLLVWSPLA 216
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
28-215 |
9.77e-12 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 64.97 E-value: 9.77e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 28 NNGVRIPALGLG---TANPHEKLAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAI--KELLEDGSIKREDLFITTKV- 101
Cdd:cd19089 6 RSGLHLPAISLGlwhNFGDYTSPEEARELLRTAFDLGITHFDLANNYGPPPGSAEENfgRILKRDLRPYRDELVISTKAg 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 102 ---WPVLWDE------VDRSLNESLKALGLEYVDLLLQHWPlcfekikDPkgisglvKTPVD----------DSGKTMYa 162
Cdd:cd19089 86 ygmWPGPYGDggsrkyLLASLDQSLKRMGLDYVDIFYHHRY-------DP-------DTPLEetmtaladavRSGKALY- 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 398365091 163 adgdyletykqlekiyldpndhrvraIGVSNFSIEYLERLIKECR---VKPTVNQV 215
Cdd:cd19089 151 --------------------------VGISNYPGAKARRAIALLRelgVPLIIHQP 180
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
30-311 |
1.03e-11 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 64.56 E-value: 1.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 30 GVRIPALGLGTAN-------PHEKlAETKQAVKAAIKAGYRHIDTAWAYET---EPFVGEAIKElledgsiKREDLFITT 99
Cdd:cd19078 1 GLEVSAIGLGCMGmshgygpPPDK-EEMIELIRKAVELGITFFDTAEVYGPytnEELVGEALKP-------FRDQVVIAT 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 100 K----------VWPVL---WDEVDRSLNESLKALGLEYVDLLLQHWPlcfekikDPkgisglvKTPVDDSGKTMyaadgd 166
Cdd:cd19078 73 KfgfkidggkpGPLGLdsrPEHIRKAVEGSLKRLQTDYIDLYYQHRV-------DP-------NVPIEEVAGTM------ 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 167 yletyKQLEKiyldpnDHRVRAIGVSNFSIEYLERLIKECRVkpTVNQVETH--PHLPQMELRKFCFMHDILLTAYSPLG 244
Cdd:cd19078 133 -----KELIK------EGKIRHWGLSEAGVETIRRAHAVCPV--TAVQSEYSmmWREPEKEVLPTLEELGIGFVPFSPLG 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 245 S---HGA--PNLKIP------------------------LVKKLAEKYNVTGNDLLISYHIRQGTIV--IPRSLNPVRIS 293
Cdd:cd19078 200 KgflTGKidENTKFDegddraslprftpealeanqalvdLLKEFAEEKGATPAQIALAWLLAKKPWIvpIPGTTKLSRLE 279
|
330 340
....*....|....*....|
gi 398365091 294 SSIEFA--SLTKDELQELND 311
Cdd:cd19078 280 ENIGAAdiELTPEELREIED 299
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
28-245 |
1.29e-11 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 64.54 E-value: 1.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 28 NNGVRIPALGLGTaNPHEKLAETKQA---VKAAIKAGYRHIDTA-----WAY-----ETEPFVGEAIKElledgSIKRED 94
Cdd:cd19081 4 RTGLSVSPLCLGT-MVFGWTADEETSfalLDAFVDAGGNFIDTAdvysaWVPgnaggESETIIGRWLKS-----RGKRDR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 95 LFITTKV-WPVLWDEVD-------RSLNESLKALGLEYVDLLLQHWPlcfekikDPkgisglvKTPVDDSgktmyaadgd 166
Cdd:cd19081 78 VVIATKVgFPMGPNGPGlsrkhirRAVEASLRRLQTDYIDLYQAHWD-------DP-------ATPLEET---------- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 167 yLETYKQLEKiyldpnDHRVRAIGVSNFSIEYLERLIKECR---------VKPTVNQVETHPHlpQMELRKFCFMHDILL 237
Cdd:cd19081 134 -LGALNDLIR------QGKVRYIGASNYSAWRLQEALELSRqhglpryvsLQPEYNLVDRESF--EGELLPLCREEGIGV 204
|
....*...
gi 398365091 238 TAYSPLGS 245
Cdd:cd19081 205 IPYSPLAG 212
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
24-243 |
2.35e-11 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 63.72 E-value: 2.35e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 24 YFSL-NNGVRIPALGLGTA-------NPHEKlaETKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKelledgSIKR 92
Cdd:cd19163 3 YRKLgKTGLKVSKLGFGASplggvfgPVDEE--EAIRTVHEALDSGINYIDTAPWYgqgRSETVLGKALK------GIPR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 93 EDLFITTKV------WPVLWD----EVDRSLNESLKALGLEYVDLLLQHwplcfekikDPKgisglvktpvddsgktmYA 162
Cdd:cd19163 75 DSYYLATKVgrygldPDKMFDfsaeRITKSVEESLKRLGLDYIDIIQVH---------DIE-----------------FA 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 163 ADGDYL--ETYKQLEKIyldPNDHRVRAIGVSNFSIEYLERLIKECRVKptVNQVETHPHlpqmelrkfCFMHDILLTAY 240
Cdd:cd19163 129 PSLDQIlnETLPALQKL---KEEGKVRFIGITGYPLDVLKEVLERSPVK--IDTVLSYCH---------YTLNDTSLLEL 194
|
...
gi 398365091 241 SPL 243
Cdd:cd19163 195 LPF 197
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
60-284 |
1.34e-10 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 61.19 E-value: 1.34e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 60 AGYRHIDTAWAY----------ETEPFVGEAIKElledgSIKREDLFITTKV---------WPVLW-----DEVDRSLNE 115
Cdd:cd19752 29 AGGNFLDTANNYafwteggvggESERLIGRWLKD-----RGNRDDVVIATKVgagprdpdgGPESPeglsaETIEQEIDK 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 116 SLKALGLEYVDLLLQHwplcfekIKDPkgisglvKTPVDDSgktmyaadgdyLETYKQLEKiyldpnDHRVRAIGVSNFS 195
Cdd:cd19752 104 SLRRLGTDYIDLYYAH-------VDDR-------DTPLEET-----------LEAFNELVK------AGKVRAIGASNFA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 196 IEYLERLIKECR----------------VKPTVN-----QVETHPhlpqmELRKFCFMHDIL-LTAYSPL--GSHGAPNL 251
Cdd:cd19752 153 AWRLERARQIARqqgwaefsaiqqrhsyLRPRPGadfgvQRIVTD-----ELLDYASSRPDLtLLAYSPLlsGAYTRPDR 227
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 398365091 252 KIP-------------LVKKLAEKYNVTGNDLLISYHIRQGTIVIP 284
Cdd:cd19752 228 PLPeqydgpdsdarlaVLEEVAGELGATPNQVVLAWLLHRTPAIIP 273
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
32-244 |
1.42e-10 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 61.46 E-value: 1.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 32 RIPALGLGT---ANPHEKLAETKQAVKA---AIKAGYRHIDTAWAY-ETEPFVGEAIKELlEDGSIKREDLFITTKVWP- 103
Cdd:cd19101 1 TISRVINGMwqlSGGHGGIRDEDAAVRAmaaYVDAGLTTFDCADIYgPAEELIGEFRKRL-RRERDAADDVQIHTKWVPd 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 104 -----VLWDEVDRSLNESLKALGLEYVDLLLQHWplcfekikdpkgisglvktpVDDSgktmyaaDGDYLETYKQLEKIy 178
Cdd:cd19101 80 pgeltMTRAYVEAAIDRSLKRLGVDRLDLVQFHW--------------------WDYS-------DPGYLDAAKHLAEL- 131
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 398365091 179 ldPNDHRVRAIGVSNFSIEYLERLIKEcRVKPTVNQVETH--PHLPQMELRKFCFMHDILLTAYSPLG 244
Cdd:cd19101 132 --QEEGKIRHLGLTNFDTERLREILDA-GVPIVSNQVQYSllDRRPENGMAALCEDHGIKLLAYGTLA 196
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
36-208 |
6.16e-10 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 59.08 E-value: 6.16e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 36 LGLGTA---------NPHEKL--AETKQAVKAAIKAGYRHIDTAWAY-ETEPFVGEAIKELledgsikrEDLFITTKV-- 101
Cdd:cd19097 3 LALGTAqfgldygiaNKSGKPseKEAKKILEYALKAGINTLDTAPAYgDSEKVLGKFLKRL--------DKFKIITKLpp 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 102 ----WPVLWDEVDRSLNESLKALGLEYVDLLLQHWPlcfekikdpkgisglvktpvddsgKTMYAADGDYLETYKQLEKI 177
Cdd:cd19097 75 lkedKKEDEAAIEASVEASLKRLKVDSLDGLLLHNP------------------------DDLLKHGGKLVEALLELKKE 130
|
170 180 190
....*....|....*....|....*....|.
gi 398365091 178 YLdpndhrVRAIGVSNFSIEYLERLIKECRV 208
Cdd:cd19097 131 GL------IRKIGVSVYSPEELEKALESFKI 155
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
34-208 |
1.21e-09 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 58.52 E-value: 1.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 34 PALGLGTANPHEKLAETKQAVKAAIKA----GYRHIDTAWAY---ETEPFVGEAIKelledgSIKREDLFITTKVWPVL- 105
Cdd:cd19162 1 PRLGLGAASLGNLARAGEDEAAATLDAawdaGIRYFDTAPLYglgLSERRLGAALA------RHPRAEYVVSTKVGRLLe 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 106 -------------WD----EVDRSLNESLKALGLEYVDLLLQHwplcfekikdpkgisglvktpvdDSGKTMYAADGDYL 168
Cdd:cd19162 75 pgaagrpagadrrFDfsadGIRRSIEASLERLGLDRLDLVFLH-----------------------DPDRHLLQALTDAF 131
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 398365091 169 ETYKQLEkiyldpNDHRVRAIGVSNFSIEYLERLIKECRV 208
Cdd:cd19162 132 PALEELR------AEGVVGAIGVGVTDWAALLRAARRADV 165
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
30-244 |
1.85e-09 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 57.97 E-value: 1.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 30 GVRIPALGLGTAN--PHEKLAETKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKElledgsiKREDLFITTKVWPV 104
Cdd:cd19087 10 GLKVSRLCLGTMNfgGRTDEETSFAIMDRALDAGINFFDTADVYgggRSEEIIGRWIAG-------RRDDIVLATKVFGP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 105 LWDEVD----------RSLNESLKALGLEYVDLLLQHWPlcfekikDPkgisglvKTPVDdsgktmyaadgdylETYKQL 174
Cdd:cd19087 83 MGDDPNdrglsrrhirRAVEASLRRLQTDYIDLYQMHHF-------DR-------DTPLE--------------ETLRAL 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 175 EKIYldpNDHRVRAIGVSNFS----IEYLE--------RLIKEcrvKPTVNQVETHphlPQMELRKFCFMHDILLTAYSP 242
Cdd:cd19087 135 DDLV---RQGKIRYIGVSNFAawqiAKAQGiaarrgllRFVSE---QPMYNLLKRQ---AELEILPAARAYGLGVIPYSP 205
|
..
gi 398365091 243 LG 244
Cdd:cd19087 206 LA 207
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
36-274 |
3.28e-09 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 57.18 E-value: 3.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 36 LGLGTANPHEKLAETK--QAVKAAIKAGYRHIDTAWAY-------ETEPFVGEAIKElledgSIKREDLFITTK----VW 102
Cdd:cd19082 3 IVLGTADFGTRIDEEEafALLDAFVELGGNFIDTARVYgdwvergASERVIGEWLKS-----RGNRDKVVIATKgghpDL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 103 PVLW------DEVDRSLNESLKALGLEYVDLLLQHwplcfekIKDPkgisglvKTPVddsgktmyaadGDYLETykqlek 176
Cdd:cd19082 78 EDMSrsrlspEDIRADLEESLERLGTDYIDLYFLH-------RDDP-------SVPV-----------GEIVDT------ 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 177 iyldPNDH----RVRAIGVSNFSIEYLERLIKECRVK----PTVNQVE------THPHLP-------QMELRKFCFMHDI 235
Cdd:cd19082 127 ----LNELvragKIRAFGASNWSTERIAEANAYAKAHglpgFAASSPQwslarpNEPPWPgptlvamDEEMRAWHEENQL 202
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 398365091 236 LLTAYSPLGS---------------------HGAPNLKI-PLVKKLAEKYNVTGNDLLISY 274
Cdd:cd19082 203 PVFAYSSQARgffskraaggaeddselrrvyYSEENFERlERAKELAEEKGVSPTQIALAY 263
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
28-133 |
5.62e-09 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 56.45 E-value: 5.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 28 NNGVRIPALGLG---TANPHEKLAETKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKELledgSIKREDLFITTKV 101
Cdd:cd19143 8 RSGLKVSALSFGswvTFGNQVDVDEAKECMKAAYDAGVNFFDNAEVYangQSEEIMGQAIKEL----GWPRSDYVVSTKI 83
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 398365091 102 WpvlW-----DEVDRSLN---------ESLKALGLEYVDLLLQHWP 133
Cdd:cd19143 84 F---WggggpPPNDRGLSrkhivegtkASLKRLQLDYVDLVFCHRP 126
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
33-131 |
9.10e-09 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 55.75 E-value: 9.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 33 IPALGLGTA------NPHEKLAETKQAVKAAIKAGYRHIDTAWAY-ETEPFVGEAIKELLEDgsIKREDLFITTKVWPVL 105
Cdd:cd19164 13 LPPLIFGAAtfsyqyTTDPESIPPVDIVRRALELGIRAFDTSPYYgPSEIILGRALKALRDE--FPRDTYFIITKVGRYG 90
|
90 100 110
....*....|....*....|....*....|...
gi 398365091 106 WDEVD-------RSLNESLKALGLEYVDLLLQH 131
Cdd:cd19164 91 PDDFDyspewirASVERSLRRLHTDYLDLVYLH 123
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
48-314 |
1.55e-08 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 55.03 E-value: 1.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 48 AETKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKElledgsIKREDLFITTKVWPVLWDE----VDRSLNESLKAL 120
Cdd:cd19103 32 DTLKAVFDKAMAAGLNLWDTAAVYgmgASEKILGEFLKR------YPREDYIISTKFTPQIAGQsadpVADMLEGSLARL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 121 GLEYVDLLLQHWPLCFEKiKDPKGISgLVKtpvddSGKtmyaadgdyletykqlekiyldpndhrVRAIGVSNFS---IE 197
Cdd:cd19103 106 GTDYIDIYWIHNPADVER-WTPELIP-LLK-----SGK---------------------------VKHVGVSNHNlaeIK 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 198 YLERLIKECRVKptVNQVETHPHL-----PQMELRKFCFMHDILLTAYS-----------------PLGSHGA------- 248
Cdd:cd19103 152 RANEILAKAGVS--LSAVQNHYSLlyrssEEAGILDYCKENGITFFAYMvleqgalsgkydtkhplPEGSGRAetynpll 229
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 249 PNLK--IPLVKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFAS--LTKDELQELNDFGE 314
Cdd:cd19103 230 PQLEelTAVMAEIGAKHGASIAQVAIAWAIAKGTTPIIGVTKPHHVEDAARAASitLTDDEIKELEQLAD 299
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
28-204 |
4.24e-08 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 53.95 E-value: 4.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 28 NNGVRIPALGLGTAnpH-----EKLAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAI--KELLEDGSIKREDLFITTK 100
Cdd:cd19151 7 RSGLKLPAISLGLW--HnfgdvDRYENSRAMLRRAFDLGITHFDLANNYGPPPGSAEENfgRILKEDLKPYRDELIISTK 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 101 VWPVLWD----------EVDRSLNESLKALGLEYVDLLLQHWPlcfekikDPkgisglvKTPVDDsgkTMYAADgdylET 170
Cdd:cd19151 85 AGYTMWPgpygdwgskkYLIASLDQSLKRMGLDYVDIFYHHRP-------DP-------ETPLEE---TMGALD----QI 143
|
170 180 190
....*....|....*....|....*....|....
gi 398365091 171 YKQLEKIYldpndhrvraIGVSNFSIEYLERLIK 204
Cdd:cd19151 144 VRQGKALY----------VGISNYPPEEAREAAA 167
|
|
| PRK09912 |
PRK09912 |
L-glyceraldehyde 3-phosphate reductase; Provisional |
29-131 |
7.48e-08 |
|
L-glyceraldehyde 3-phosphate reductase; Provisional
Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 53.45 E-value: 7.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 29 NGVRIPALGLGTANP--HEKLAETKQAV-KAAIKAGYRHIDTAWAYETEPFVGEAI--KELLEDGSIKREDLFITTK--- 100
Cdd:PRK09912 21 SGLRLPALSLGLWHNfgHVNALESQRAIlRKAFDLGITHFDLANNYGPPPGSAEENfgRLLREDFAAYRDELIISTKagy 100
|
90 100 110
....*....|....*....|....*....|....*...
gi 398365091 101 -VWPVLWDE------VDRSLNESLKALGLEYVDLLLQH 131
Cdd:PRK09912 101 dMWPGPYGSggsrkyLLASLDQSLKRMGLEYVDIFYSH 138
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
36-244 |
1.29e-07 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 52.57 E-value: 1.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 36 LGLGTANPHEKLAEtKQAVK---AAIKAGYRHIDTAWAY----------ETEPFVGEAIKelledGSIKREDLFITTKV- 101
Cdd:cd19094 4 ICLGTMTWGEQNTE-AEAHEqldYAFDEGVNFIDTAEMYpvppspetqgRTEEIIGSWLK-----KKGNRDKVVLATKVa 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 102 -------WP------VLWDEVDRSLNESLKALGLEYVDLLLQHWPlcfekikdpkgisglvKTPVDDSGKTMYAADG--- 165
Cdd:cd19094 78 gpgegitWPrgggtrLDRENIREAVEGSLKRLGTDYIDLYQLHWP----------------DRYTPLFGGGYYTEPSeee 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 166 ---DYLETYKQLEKIYldpNDHRVRAIGVSN---FSI-EYLErlikecrvkptvnQVETHpHLPQMEL---------RKF 229
Cdd:cd19094 142 dsvSFEEQLEALGELV---KAGKIRHIGLSNetpWGVmKFLE-------------LAEQL-GLPRIVSiqnpysllnRNF 204
|
250 260
....*....|....*....|..
gi 398365091 230 -------CFMHDILLTAYSPLG 244
Cdd:cd19094 205 eeglaeaCHRENVGLLAYSPLA 226
|
|
| AKR_AKR14A1 |
cd19150 |
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ... |
30-131 |
2.30e-07 |
|
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Pssm-ID: 381376 [Multi-domain] Cd Length: 309 Bit Score: 51.69 E-value: 2.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 30 GVRIPALGLGT------ANPHEklaeTKQAV-KAAIKAGYRHIDTAWAYETEPFVGE-AIKELL-EDGSIKREDLFITTK 100
Cdd:cd19150 9 GLKLPALSLGLwhnfgdDTPLE----TQRAIlRTAFDLGITHFDLANNYGPPPGSAEeNFGRILrEDFAGYRDELIISTK 84
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 398365091 101 ----VWPVLWDE------VDRSLNESLKALGLEYVDLLLQH 131
Cdd:cd19150 85 agydMWPGPYGEwgsrkyLLASLDQSLKRMGLDYVDIFYSH 125
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
28-221 |
7.29e-07 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 50.23 E-value: 7.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 28 NNGVRIPALGLGTA--------NPHEKLAEtkQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKELledgSIKREDLF 96
Cdd:cd19153 7 IALGNVSPVGLGTAalggvygdGLEQDEAV--AIVAEAFAAGINHFDTSPYYgaeSSEAVLGKALAAL----QVPRSSYT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 97 ITTKV-------WPVLWDEVDRSLNESLKALGLEYVDLLLQHwplcfekikDPKGISglvktpvddsgktmyaADGDYLE 169
Cdd:cd19153 81 VATKVgryrdseFDYSAERVRASVATSLERLHTTYLDVVYLH---------DIEFVD----------------YDTLVDE 135
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 398365091 170 TYKQLEKIyldPNDHRVRAIGVSNFSIEYLERLIKECRVKPtVNQVETHPHL 221
Cdd:cd19153 136 ALPALRTL---KDEGVIKRIGIAGYPLDTLTRATRRCSPGS-LDAVLSYCHL 183
|
|
| AKR_AKR15A1 |
cd19161 |
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ... |
34-131 |
1.37e-06 |
|
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.
Pssm-ID: 381387 [Multi-domain] Cd Length: 310 Bit Score: 49.25 E-value: 1.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 34 PALGLGTAN-----PHEKLAETKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKELledgsiKREDLFITTKVWPVL 105
Cdd:cd19161 1 SELGLGTAGlgnlyTAVSNADADATLDAAWDSGIRYFDTAPMYghgLAEHRLGDFLREK------PRDEFVLSTKVGRLL 74
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 398365091 106 ---------------------------WDEVDRSLNESLKALGLEYVDLLLQH 131
Cdd:cd19161 75 kparegsvpdpngfvdplpfeivydysYDGIMRSFEDSLQRLGLNRIDILYVH 127
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
29-161 |
1.01e-05 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 46.69 E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 29 NGVRIPALGLGT-----ANPHEKLAEtkQAVKAAIKAGYRHIDTawayeTEPFVGEAIKELLedGSI------KREDLFI 97
Cdd:cd19142 9 SGLRVSNVGLGTwstfsTAISEEQAE--EIVTLAYENGINYFDT-----SDAFTSGQAETEL--GRIlkkkgwKRSSYIV 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 398365091 98 TTKVWpvlWD--EVDRSLN-----ESLKA----LGLEYVDLLLQHW--PLC-FEKIKdpKGISGLVKTpvddsGKTMY 161
Cdd:cd19142 80 STKIY---WSygSEERGLSrkhiiESVRAslrrLQLDYIDIVIIHKadPMCpMEEVV--RAMSYLIDN-----GLIMY 147
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
24-133 |
1.55e-05 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 46.06 E-value: 1.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 24 YFSLNNGVRIPALGLGT----------ANPheklAETKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKElledgsi 90
Cdd:cd19080 1 RLLGRSGLRVSPLALGTmtfgtewgwgADR----EEARAMFDAYVEAGGNFIDTANNYtngTSERLLGEFIAG------- 69
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 398365091 91 KREDLFITTK-VWPVLWDEVD----------RSLNESLKALGLEYVDLLLQHWP 133
Cdd:cd19080 70 NRDRIVLATKyTMNRRPGDPNaggnhrknlrRSVEASLRRLQTDYIDLLYVHAW 123
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
32-193 |
2.10e-05 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 45.62 E-value: 2.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 32 RIP-------ALGLGTANPHEK--LAETKQAVKAAIKAGYRHIDTAWAYE----------TEPFVGEAIKElleDGSikR 92
Cdd:PRK10625 5 RIPhsslevsTLGLGTMTFGEQnsEADAHAQLDYAVAQGINLIDVAEMYPvpprpetqglTETYIGNWLAK---RGS--R 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 93 EDLFITTKV-WPVLWDE--------VDR-----SLNESLKALGLEYVDLLLQHWPL----CFEKIkdpkGISGLVKTPVD 154
Cdd:PRK10625 80 EKLIIASKVsGPSRNNDkgirpnqaLDRknireALHDSLKRLQTDYLDLYQVHWPQrptnCFGKL----GYSWTDSAPAV 155
|
170 180 190
....*....|....*....|....*....|....*....
gi 398365091 155 DSGKTMYAadgdyLETYKQLEKIyldpndhrvRAIGVSN 193
Cdd:PRK10625 156 SLLETLDA-----LAEQQRAGKI---------RYIGVSN 180
|
|
| PLN02587 |
PLN02587 |
L-galactose dehydrogenase |
28-131 |
6.96e-04 |
|
L-galactose dehydrogenase
Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 40.92 E-value: 6.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 28 NNGVRIPALGLGTA---NPHEKLAE--TKQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKELledgSIKREDLFITT 99
Cdd:PLN02587 6 STGLKVSSVGFGASplgSVFGPVSEedAIASVREAFRLGINFFDTSPYYggtLSEKVLGKALKAL----GIPREKYVVST 81
|
90 100 110
....*....|....*....|....*....|....*...
gi 398365091 100 KV------WPVLWDEVDRSLNESLKALGLEYVDLLLQH 131
Cdd:PLN02587 82 KCgrygegFDFSAERVTKSVDESLARLQLDYVDILHCH 119
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
29-133 |
9.25e-04 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 40.80 E-value: 9.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 29 NGVRIPALGLGT-----ANPHEKLAEtkQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKElledGSIKREDLFITTK 100
Cdd:cd19159 9 SGLRVSCLGLGTwvtfgGQISDEVAE--RLMTIAYESGVNLFDTAEVYaagKAEVILGSIIKK----KGWRRSSLVITTK 82
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 398365091 101 VWPVLWDEVDRSLNE---------SLKALGLEYVDLLLQHWP 133
Cdd:cd19159 83 LYWGGKAETERGLSRkhiieglkgSLQRLQLEYVDVVFANRP 124
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
29-160 |
2.78e-03 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 39.30 E-value: 2.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 29 NGVRIPALGLGT-----ANPHEKLAEtkQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKElledGSIKREDLFITTK 100
Cdd:cd19158 9 SGLRVSCLGLGTwvtfgGQITDEMAE--HLMTLAYDNGINLFDTAEVYaagKAEVVLGNIIKK----KGWRRSSLVITTK 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 398365091 101 VWPVLWDEVDRSLNE---------SLKALGLEYVDLLLQHWPlcfekikDPkgisglvKTPVDDSGKTM 160
Cdd:cd19158 83 IFWGGKAETERGLSRkhiieglkaSLERLQLEYVDVVFANRP-------DP-------NTPMEETVRAM 137
|
|
| PRK10376 |
PRK10376 |
putative oxidoreductase; Provisional |
53-127 |
5.48e-03 |
|
putative oxidoreductase; Provisional
Pssm-ID: 236676 [Multi-domain] Cd Length: 290 Bit Score: 38.03 E-value: 5.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 53 AV-KAAIKAGYRHIDTAWAYetEPFV-GEAIKELLEDGsikREDLFITTKV---------WPVLW--DEVDRSLNESLKA 119
Cdd:PRK10376 44 AVlREAVALGVNHIDTSDFY--GPHVtNQLIREALHPY---PDDLTIVTKVgarrgedgsWLPAFspAELRRAVHDNLRN 118
|
....*...
gi 398365091 120 LGLEYVDL 127
Cdd:PRK10376 119 LGLDVLDV 126
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
30-133 |
6.17e-03 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 37.81 E-value: 6.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365091 30 GVRIPALGLGT-----ANPHEKLAEtkQAVKAAIKAGYRHIDTAWAY---ETEPFVGEAIKElledGSIKREDLFITTKV 101
Cdd:cd19141 9 GLRVSCLGLGTwvtfgSQISDEVAE--ELVTLAYENGINLFDTAEVYaagKAEIVLGKILKK----KGWRRSSYVITTKI 82
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 398365091 102 WpvlWD---EVDRS---------LNESLKALGLEYVDLLLQHWP 133
Cdd:cd19141 83 F---WGgkaETERGlsrkhiiegLKASLERLQLEYVDIVFANRP 123
|
|
| |
