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Conserved domains on  [gi|6319968|ref|NP_010048|]
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Mfg1p [Saccharomyces cerevisiae S288C]

Protein Classification

LIM domain-binding protein( domain architecture ID 10485175)

LIM domain-binding protein binds to the LIM domain of LIM homeodomain proteins, which are transcriptional regulators of development; similar to Arabidopsis thaliana transcriptional corepressor SEUSS

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LIM_bind pfam01803
LIM-domain binding protein; The LIM-domain binding protein, binds to the LIM domain pfam00412 ...
 151-393 1.89e-64

LIM-domain binding protein; The LIM-domain binding protein, binds to the LIM domain pfam00412 of LIM homeodomain proteins which are transcriptional regulators of development. Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) is located in the nuclei of neuronal cells during development, it is co-expressed with Isl1 in early motor neuron differentiation and has a suggested role in the Isl1 dependent development of motor neurons. It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development. The Drosophila protein Chip is required for segmentation and activity of a remote wing margin enhancer. Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development. It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions.


:

Pssm-ID: 426444  Cd Length: 242  Bit Score: 207.90  E-value: 1.89e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319968    151 KLYEIINEVNTAMGKIGLLSFWTELISDIFTPDAVIRYSKKSMT----DYREFEFIIPVFPVICSTLGRFGIVRMEVKVL 226
Cdd:pfam01803   1 RLLQFIEHLSNFSKNLNDIEYWQKFVAEFFSPTGVLRHSLKSYDcggkEPKQFEITTPALPRYFVTLFDSGVKRIQLILD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319968    227 QLKTQVLSNSTIFFNCPRVTFVYYYPDGSYITHFSQMKGAFDLDLKINWLDVSMHSFVPDIEWNAVERLLSDDTKSTEIE 306
Cdd:pfam01803  81 GAREQVLSNGSIFVECPKASFTYWYEDGSQVVLTGQLRALFDADLKIEWLEFCTRSHEEYIPRNSLEKLLKQLHEWADLS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319968    307 QIFRKLKQEDvKEQGNSFAENNATNVPPNFEAITQLRSYFdvfrnVSVFGTQEGLMRVMQISTVMSTLKNLRKFQIEKNI 386
Cdd:pfam01803 161 QSPKMSKKVL-QKQQIFQALSSKSPAPEPPEAIKELPSSF-----VNDFGIPEAVMRFLQIGEVMSSMKDLMEFSKQNNI 234


                  ....*..
gi 6319968    387 DSPVTAL 393
Cdd:pfam01803 235 LSPLEAL 241
PAT1 super family cl37801
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 34-141 1.51e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


The actual alignment was detected with superfamily member pfam09770:

Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 41.17  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319968     34 PPTAQQNIPPTVYPQQVPFPGQPQGGQFPQPSSEQQVFNQLPQVTQTFHNSAQNTNATGGPGSGSMPMFTPVA-SFPHPM 112
Cdd:pfam09770 209 KPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIqPQAQQF 288

                          90       100       110
                  ....*....|....*....|....*....|.
gi 6319968    113 ATAATAAAPLPRSASQ--ASLSMLRVPYHVR 141
Cdd:pfam09770 289 HQQPPPVPVQPTQILQnpNRLSAARVGYPQN 319
 
Name Accession Description Interval E-value
LIM_bind pfam01803
LIM-domain binding protein; The LIM-domain binding protein, binds to the LIM domain pfam00412 ...
 151-393 1.89e-64

LIM-domain binding protein; The LIM-domain binding protein, binds to the LIM domain pfam00412 of LIM homeodomain proteins which are transcriptional regulators of development. Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) is located in the nuclei of neuronal cells during development, it is co-expressed with Isl1 in early motor neuron differentiation and has a suggested role in the Isl1 dependent development of motor neurons. It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development. The Drosophila protein Chip is required for segmentation and activity of a remote wing margin enhancer. Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development. It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions.


Pssm-ID: 426444  Cd Length: 242  Bit Score: 207.90  E-value: 1.89e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319968    151 KLYEIINEVNTAMGKIGLLSFWTELISDIFTPDAVIRYSKKSMT----DYREFEFIIPVFPVICSTLGRFGIVRMEVKVL 226
Cdd:pfam01803   1 RLLQFIEHLSNFSKNLNDIEYWQKFVAEFFSPTGVLRHSLKSYDcggkEPKQFEITTPALPRYFVTLFDSGVKRIQLILD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319968    227 QLKTQVLSNSTIFFNCPRVTFVYYYPDGSYITHFSQMKGAFDLDLKINWLDVSMHSFVPDIEWNAVERLLSDDTKSTEIE 306
Cdd:pfam01803  81 GAREQVLSNGSIFVECPKASFTYWYEDGSQVVLTGQLRALFDADLKIEWLEFCTRSHEEYIPRNSLEKLLKQLHEWADLS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319968    307 QIFRKLKQEDvKEQGNSFAENNATNVPPNFEAITQLRSYFdvfrnVSVFGTQEGLMRVMQISTVMSTLKNLRKFQIEKNI 386
Cdd:pfam01803 161 QSPKMSKKVL-QKQQIFQALSSKSPAPEPPEAIKELPSSF-----VNDFGIPEAVMRFLQIGEVMSSMKDLMEFSKQNNI 234


                  ....*..
gi 6319968    387 DSPVTAL 393
Cdd:pfam01803 235 LSPLEAL 241
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 34-141 1.51e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 41.17  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319968     34 PPTAQQNIPPTVYPQQVPFPGQPQGGQFPQPSSEQQVFNQLPQVTQTFHNSAQNTNATGGPGSGSMPMFTPVA-SFPHPM 112
Cdd:pfam09770 209 KPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIqPQAQQF 288

                          90       100       110
                  ....*....|....*....|....*....|.
gi 6319968    113 ATAATAAAPLPRSASQ--ASLSMLRVPYHVR 141
Cdd:pfam09770 289 HQQPPPVPVQPTQILQnpNRLSAARVGYPQN 319
 
Name Accession Description Interval E-value
LIM_bind pfam01803
LIM-domain binding protein; The LIM-domain binding protein, binds to the LIM domain pfam00412 ...
 151-393 1.89e-64

LIM-domain binding protein; The LIM-domain binding protein, binds to the LIM domain pfam00412 of LIM homeodomain proteins which are transcriptional regulators of development. Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) is located in the nuclei of neuronal cells during development, it is co-expressed with Isl1 in early motor neuron differentiation and has a suggested role in the Isl1 dependent development of motor neurons. It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development. The Drosophila protein Chip is required for segmentation and activity of a remote wing margin enhancer. Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development. It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions.


Pssm-ID: 426444  Cd Length: 242  Bit Score: 207.90  E-value: 1.89e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319968    151 KLYEIINEVNTAMGKIGLLSFWTELISDIFTPDAVIRYSKKSMT----DYREFEFIIPVFPVICSTLGRFGIVRMEVKVL 226
Cdd:pfam01803   1 RLLQFIEHLSNFSKNLNDIEYWQKFVAEFFSPTGVLRHSLKSYDcggkEPKQFEITTPALPRYFVTLFDSGVKRIQLILD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319968    227 QLKTQVLSNSTIFFNCPRVTFVYYYPDGSYITHFSQMKGAFDLDLKINWLDVSMHSFVPDIEWNAVERLLSDDTKSTEIE 306
Cdd:pfam01803  81 GAREQVLSNGSIFVECPKASFTYWYEDGSQVVLTGQLRALFDADLKIEWLEFCTRSHEEYIPRNSLEKLLKQLHEWADLS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319968    307 QIFRKLKQEDvKEQGNSFAENNATNVPPNFEAITQLRSYFdvfrnVSVFGTQEGLMRVMQISTVMSTLKNLRKFQIEKNI 386
Cdd:pfam01803 161 QSPKMSKKVL-QKQQIFQALSSKSPAPEPPEAIKELPSSF-----VNDFGIPEAVMRFLQIGEVMSSMKDLMEFSKQNNI 234


                  ....*..
gi 6319968    387 DSPVTAL 393
Cdd:pfam01803 235 LSPLEAL 241
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 34-141 1.51e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 41.17  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319968     34 PPTAQQNIPPTVYPQQVPFPGQPQGGQFPQPSSEQQVFNQLPQVTQTFHNSAQNTNATGGPGSGSMPMFTPVA-SFPHPM 112
Cdd:pfam09770 209 KPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIqPQAQQF 288

                          90       100       110
                  ....*....|....*....|....*....|.
gi 6319968    113 ATAATAAAPLPRSASQ--ASLSMLRVPYHVR 141
Cdd:pfam09770 289 HQQPPPVPVQPTQILQnpNRLSAARVGYPQN 319
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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