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Conserved domains on  [gi|398364901|ref|NP_010279|]
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Med2p [Saccharomyces cerevisiae S288C]

Protein Classification

Med2 domain-containing protein( domain architecture ID 10567881)

Med2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Med2 pfam11214
Mediator complex subunit 2; This family of mediator complex subunit 2 proteins is conserved in ...
 27-141 2.48e-35

Mediator complex subunit 2; This family of mediator complex subunit 2 proteins is conserved in fungi. Cyclin-dependent kinase CDK8 or Srb10 interacts with and phosphorylates Med2. Post-translational modifications of Mediator subunits are important for regulation of gene expression.


:

Pssm-ID: 402683  Cd Length: 100  Bit Score: 125.88  E-value: 2.48e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364901   27 TYKNKLTVCFDDILKVGAEMMMQQQLKNVQLDSYLVNGFSQSQQKLLKEKVKLFHGILDDLETSLSQSSSYLETLTALGk 106
Cdd:pfam11214   1 NLQNKLTQCLDDILKTSGEMFVQQQLKTIQLQSNVITGFNNQLQKSLSEKIHLFHSILDDTETTLNDAKWCVETIVENK- 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 398364901  107 ekekereeaekkrAEQENMrKVREQEELKKRQELE 141
Cdd:pfam11214  80 -------------QEKEEE-KEKEEEERQRKEEEE 100
 
Name Accession Description Interval E-value
Med2 pfam11214
Mediator complex subunit 2; This family of mediator complex subunit 2 proteins is conserved in ...
 27-141 2.48e-35

Mediator complex subunit 2; This family of mediator complex subunit 2 proteins is conserved in fungi. Cyclin-dependent kinase CDK8 or Srb10 interacts with and phosphorylates Med2. Post-translational modifications of Mediator subunits are important for regulation of gene expression.


Pssm-ID: 402683  Cd Length: 100  Bit Score: 125.88  E-value: 2.48e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364901   27 TYKNKLTVCFDDILKVGAEMMMQQQLKNVQLDSYLVNGFSQSQQKLLKEKVKLFHGILDDLETSLSQSSSYLETLTALGk 106
Cdd:pfam11214   1 NLQNKLTQCLDDILKTSGEMFVQQQLKTIQLQSNVITGFNNQLQKSLSEKIHLFHSILDDTETTLNDAKWCVETIVENK- 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 398364901  107 ekekereeaekkrAEQENMrKVREQEELKKRQELE 141
Cdd:pfam11214  80 -------------QEKEEE-KEKEEEERQRKEEEE 100
 
Name Accession Description Interval E-value
Med2 pfam11214
Mediator complex subunit 2; This family of mediator complex subunit 2 proteins is conserved in ...
 27-141 2.48e-35

Mediator complex subunit 2; This family of mediator complex subunit 2 proteins is conserved in fungi. Cyclin-dependent kinase CDK8 or Srb10 interacts with and phosphorylates Med2. Post-translational modifications of Mediator subunits are important for regulation of gene expression.


Pssm-ID: 402683  Cd Length: 100  Bit Score: 125.88  E-value: 2.48e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364901   27 TYKNKLTVCFDDILKVGAEMMMQQQLKNVQLDSYLVNGFSQSQQKLLKEKVKLFHGILDDLETSLSQSSSYLETLTALGk 106
Cdd:pfam11214   1 NLQNKLTQCLDDILKTSGEMFVQQQLKTIQLQSNVITGFNNQLQKSLSEKIHLFHSILDDTETTLNDAKWCVETIVENK- 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 398364901  107 ekekereeaekkrAEQENMrKVREQEELKKRQELE 141
Cdd:pfam11214  80 -------------QEKEEE-KEKEEEERQRKEEEE 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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