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Conserved domains on  [gi|398366583|ref|NP_010710|]
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Sip1p [Saccharomyces cerevisiae S288C]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AMPKBI smart01010
5'-AMP-activated protein kinase beta subunit, interation domain; This region is found in the ...
 687-804 2.68e-29

5'-AMP-activated protein kinase beta subunit, interation domain; This region is found in the beta subunit of the 5'-AMP-activated protein kinase complex, and its yeast homologues Sip1, Sip2 and Gal83, which are found in the SNF1 kinase complex. This region is sufficient for interaction of this subunit with the kinase complex, but is not solely responsible for the interaction, and the interaction partner is not known. The isoamylase N-terminal domain is sometimes found in proteins belonging to this family.


:

Pssm-ID: 214973  Cd Length: 100  Bit Score: 112.03  E-value: 2.68e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366583   687 EPPSFTHRVVDCNQDDLFATLQQggnidaetaeavfLSRYPVP-DLPIYLNSSYLNrilnqsnqNSESHERDEGAINHII 765
Cdd:smart01010   3 PPESYTNEIPACFTDDDFIEESP-------------EEKWKEPpALPPHLEKVILN--------TSSTATREDPSLLPIP 61

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 398366583   766 PHVNLNHLLTSSIRDEIISVACTTRYEGKFITQVVYAPC 804
Cdd:smart01010  62 NHVVLNHLYTSSIKDGVLAVAATTRYRGKYVTQVLYKPL 100
AMPK1_CBM super family cl48298
Glycogen recognition site of AMP-activated protein kinase; AMPK1_CBM is a family found in ...
 504-562 1.98e-09

Glycogen recognition site of AMP-activated protein kinase; AMPK1_CBM is a family found in close association with AMPKBI pfam04739. The surface of AMPK1_CBM reveals a carbohydrate-binding pocket.


The actual alignment was detected with superfamily member pfam16561:

Pssm-ID: 465176 [Multi-domain]  Cd Length: 85  Bit Score: 54.84  E-value: 1.98e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 398366583  504 RIRMVYddvHKEWFVPDLFLPAGIYRLQFSINGILTHSNFLPTATDSEGNFVNWFEVLP 562
Cdd:pfam16561  26 KIPLQK---SGGDFTTILDLPPGTHQYKFIVDGEWRHDPDLPTATDDMGNLNNYIEVKA 81
 
Name Accession Description Interval E-value
AMPKBI smart01010
5'-AMP-activated protein kinase beta subunit, interation domain; This region is found in the ...
 687-804 2.68e-29

5'-AMP-activated protein kinase beta subunit, interation domain; This region is found in the beta subunit of the 5'-AMP-activated protein kinase complex, and its yeast homologues Sip1, Sip2 and Gal83, which are found in the SNF1 kinase complex. This region is sufficient for interaction of this subunit with the kinase complex, but is not solely responsible for the interaction, and the interaction partner is not known. The isoamylase N-terminal domain is sometimes found in proteins belonging to this family.


Pssm-ID: 214973  Cd Length: 100  Bit Score: 112.03  E-value: 2.68e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366583   687 EPPSFTHRVVDCNQDDLFATLQQggnidaetaeavfLSRYPVP-DLPIYLNSSYLNrilnqsnqNSESHERDEGAINHII 765
Cdd:smart01010   3 PPESYTNEIPACFTDDDFIEESP-------------EEKWKEPpALPPHLEKVILN--------TSSTATREDPSLLPIP 61

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 398366583   766 PHVNLNHLLTSSIRDEIISVACTTRYEGKFITQVVYAPC 804
Cdd:smart01010  62 NHVVLNHLYTSSIKDGVLAVAATTRYRGKYVTQVLYKPL 100
AMPKBI pfam04739
5'-AMP-activated protein kinase beta subunit, interaction domain; This region is found in the ...
 729-803 5.73e-22

5'-AMP-activated protein kinase beta subunit, interaction domain; This region is found in the beta subunit of the 5'-AMP-activated protein kinase complex, and its yeast homologs Sip1, Sip2 and Gal83, which are found in the SNF1 kinase complex. This region is sufficient for interaction of this subunit with the kinase complex, but is not solely responsible for the interaction, and the interaction partner is not known. The isoamylase N-terminal domain (pfam02922) is sometimes found in proteins belonging to this family.


Pssm-ID: 461416  Cd Length: 70  Bit Score: 89.90  E-value: 5.73e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 398366583  729 PDLPIYLNSSYLNRILNQSNQNsesherdegainHIIP---HVNLNHLLTSSIRDEIISVACTTRYEGKFITQVVYAP 803
Cdd:pfam04739   5 PALPPHLHLTILNKPSSSSDDP------------SLLPrpnHVVLNHLYTSSIKDGVLALGTTHRYKSKYVTTVLYKP 70
AMPK1_CBM pfam16561
Glycogen recognition site of AMP-activated protein kinase; AMPK1_CBM is a family found in ...
 504-562 1.98e-09

Glycogen recognition site of AMP-activated protein kinase; AMPK1_CBM is a family found in close association with AMPKBI pfam04739. The surface of AMPK1_CBM reveals a carbohydrate-binding pocket.


Pssm-ID: 465176 [Multi-domain]  Cd Length: 85  Bit Score: 54.84  E-value: 1.98e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 398366583  504 RIRMVYddvHKEWFVPDLFLPAGIYRLQFSINGILTHSNFLPTATDSEGNFVNWFEVLP 562
Cdd:pfam16561  26 KIPLQK---SGGDFTTILDLPPGTHQYKFIVDGEWRHDPDLPTATDDMGNLNNYIEVKA 81
E_set_AMPKbeta_like_N cd02859
N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain ...
 504-560 1.45e-05

N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; E or "early" set domains are associated with the catalytic domain of AMP-activated protein kinase beta subunit glycogen binding domain at the N-terminal end. AMPK is a metabolic stress sensing protein that senses AMP/ATP and has recently been found to act as a glycogen sensor as well. The protein functions as an alpha-beta-gamma heterotrimer. This N-terminal domain is the glycogen binding domain of the beta subunit. This domain is also a member of the CBM48 (Carbohydrate Binding Module 48) family whose members include pullulanase, maltooligosyl trehalose synthase, starch branching enzyme, glycogen branching enzyme, glycogen debranching enzyme, and isoamylase.


Pssm-ID: 199889 [Multi-domain]  Cd Length: 80  Bit Score: 43.74  E-value: 1.45e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 398366583 504 RIRMVYDDvHKEWFVpDLFLPAGIYRLQFSINGILTHSNFLPTATDSEGNFVNWFEV 560
Cdd:cd02859   26 PIPLEKSG-DGEFSA-TVELPPGRYEYKFIVDGEWVHDPDLPTVTDEFGNLNNVLEV 80
 
Name Accession Description Interval E-value
AMPKBI smart01010
5'-AMP-activated protein kinase beta subunit, interation domain; This region is found in the ...
 687-804 2.68e-29

5'-AMP-activated protein kinase beta subunit, interation domain; This region is found in the beta subunit of the 5'-AMP-activated protein kinase complex, and its yeast homologues Sip1, Sip2 and Gal83, which are found in the SNF1 kinase complex. This region is sufficient for interaction of this subunit with the kinase complex, but is not solely responsible for the interaction, and the interaction partner is not known. The isoamylase N-terminal domain is sometimes found in proteins belonging to this family.


Pssm-ID: 214973  Cd Length: 100  Bit Score: 112.03  E-value: 2.68e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366583   687 EPPSFTHRVVDCNQDDLFATLQQggnidaetaeavfLSRYPVP-DLPIYLNSSYLNrilnqsnqNSESHERDEGAINHII 765
Cdd:smart01010   3 PPESYTNEIPACFTDDDFIEESP-------------EEKWKEPpALPPHLEKVILN--------TSSTATREDPSLLPIP 61

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 398366583   766 PHVNLNHLLTSSIRDEIISVACTTRYEGKFITQVVYAPC 804
Cdd:smart01010  62 NHVVLNHLYTSSIKDGVLAVAATTRYRGKYVTQVLYKPL 100
AMPKBI pfam04739
5'-AMP-activated protein kinase beta subunit, interaction domain; This region is found in the ...
 729-803 5.73e-22

5'-AMP-activated protein kinase beta subunit, interaction domain; This region is found in the beta subunit of the 5'-AMP-activated protein kinase complex, and its yeast homologs Sip1, Sip2 and Gal83, which are found in the SNF1 kinase complex. This region is sufficient for interaction of this subunit with the kinase complex, but is not solely responsible for the interaction, and the interaction partner is not known. The isoamylase N-terminal domain (pfam02922) is sometimes found in proteins belonging to this family.


Pssm-ID: 461416  Cd Length: 70  Bit Score: 89.90  E-value: 5.73e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 398366583  729 PDLPIYLNSSYLNRILNQSNQNsesherdegainHIIP---HVNLNHLLTSSIRDEIISVACTTRYEGKFITQVVYAP 803
Cdd:pfam04739   5 PALPPHLHLTILNKPSSSSDDP------------SLLPrpnHVVLNHLYTSSIKDGVLALGTTHRYKSKYVTTVLYKP 70
AMPK1_CBM pfam16561
Glycogen recognition site of AMP-activated protein kinase; AMPK1_CBM is a family found in ...
 504-562 1.98e-09

Glycogen recognition site of AMP-activated protein kinase; AMPK1_CBM is a family found in close association with AMPKBI pfam04739. The surface of AMPK1_CBM reveals a carbohydrate-binding pocket.


Pssm-ID: 465176 [Multi-domain]  Cd Length: 85  Bit Score: 54.84  E-value: 1.98e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 398366583  504 RIRMVYddvHKEWFVPDLFLPAGIYRLQFSINGILTHSNFLPTATDSEGNFVNWFEVLP 562
Cdd:pfam16561  26 KIPLQK---SGGDFTTILDLPPGTHQYKFIVDGEWRHDPDLPTATDDMGNLNNYIEVKA 81
E_set_AMPKbeta_like_N cd02859
N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain ...
 504-560 1.45e-05

N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; E or "early" set domains are associated with the catalytic domain of AMP-activated protein kinase beta subunit glycogen binding domain at the N-terminal end. AMPK is a metabolic stress sensing protein that senses AMP/ATP and has recently been found to act as a glycogen sensor as well. The protein functions as an alpha-beta-gamma heterotrimer. This N-terminal domain is the glycogen binding domain of the beta subunit. This domain is also a member of the CBM48 (Carbohydrate Binding Module 48) family whose members include pullulanase, maltooligosyl trehalose synthase, starch branching enzyme, glycogen branching enzyme, glycogen debranching enzyme, and isoamylase.


Pssm-ID: 199889 [Multi-domain]  Cd Length: 80  Bit Score: 43.74  E-value: 1.45e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 398366583 504 RIRMVYDDvHKEWFVpDLFLPAGIYRLQFSINGILTHSNFLPTATDSEGNFVNWFEV 560
Cdd:cd02859   26 PIPLEKSG-DGEFSA-TVELPPGRYEYKFIVDGEWVHDPDLPTVTDEFGNLNNVLEV 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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