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Conserved domains on  [gi|6320701|ref|NP_010781|]
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Mzm1p [Saccharomyces cerevisiae S288C]

Protein Classification

LYR motif-containing protein( domain architecture ID 14448842)

LYR motif-containing protein plays a key role in the assembly and function of complexes I, II, and III; LYR motifs are molecular signatures of specific recipient Fe-S proteins or accessory factors that assist Fe-S cluster delivery

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Complex1_LYR_LYRM7 cd20267
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and ...
 7-75 2.26e-13

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and similar proteins; LYRM7 is an assembly factor required for Rieske iron sulfur (Fe-S) protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. It functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. LYRM7 mutations cause a multifocal cavitating leukoencephalopathy with a distinct and recognizable magnetic resonance imaging (MRI) pattern. LYRM7 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


:

Pssm-ID: 380762  Cd Length: 72  Bit Score: 60.27  E-value: 2.26e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6320701    7 ALNAYRHGLRATRIAFRNDAEVLLAARAKMRSGML---CPPDPKLTTEdQIQHLEDVAVFLRRNLVQGKKVD 75
Cdd:cd20267   1 VLSAYRELLRARRWVFKGDTPALKAARQKIREEFEknrNETDPEKIAE-LLKEAREAAEFLRKNVVQAVLNE 71
 
Name Accession Description Interval E-value
Complex1_LYR_LYRM7 cd20267
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and ...
 7-75 2.26e-13

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and similar proteins; LYRM7 is an assembly factor required for Rieske iron sulfur (Fe-S) protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. It functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. LYRM7 mutations cause a multifocal cavitating leukoencephalopathy with a distinct and recognizable magnetic resonance imaging (MRI) pattern. LYRM7 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380762  Cd Length: 72  Bit Score: 60.27  E-value: 2.26e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6320701    7 ALNAYRHGLRATRIAFRNDAEVLLAARAKMRSGML---CPPDPKLTTEdQIQHLEDVAVFLRRNLVQGKKVD 75
Cdd:cd20267   1 VLSAYRELLRARRWVFKGDTPALKAARQKIREEFEknrNETDPEKIAE-LLKEAREAAEFLRKNVVQAVLNE 71
 
Name Accession Description Interval E-value
Complex1_LYR_LYRM7 cd20267
LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and ...
 7-75 2.26e-13

LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and similar proteins; LYRM7 is an assembly factor required for Rieske iron sulfur (Fe-S) protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. It functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. LYRM7 mutations cause a multifocal cavitating leukoencephalopathy with a distinct and recognizable magnetic resonance imaging (MRI) pattern. LYRM7 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380762  Cd Length: 72  Bit Score: 60.27  E-value: 2.26e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6320701    7 ALNAYRHGLRATRIAFRNDAEVLLAARAKMRSGML---CPPDPKLTTEdQIQHLEDVAVFLRRNLVQGKKVD 75
Cdd:cd20267   1 VLSAYRELLRARRWVFKGDTPALKAARQKIREEFEknrNETDPEKIAE-LLKEAREAAEFLRKNVVQAVLNE 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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