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Conserved domains on  [gi|6320709|ref|NP_010789|]
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Plm2p [Saccharomyces cerevisiae S288C]

Protein Classification

FHA domain-containing protein( domain architecture ID 17783916)

FHA (forkhead-associated) domain-containing protein participates in signal transduction pathways via protein-protein interactions involving recognition of pThr and pTyr phosphopeptides

CATH:  2.60.200.20
Gene Ontology:  GO:0006974|GO:0003682|GO:0071444|GO:0051726|GO:0006623|GO:0031929|GO:0005515
PubMed:  10518219|11069759|7482699
SCOP:  4002605

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FHA_PLM2-like cd22699
forkhead associated (FHA) domain found in Saccharomyces cerevisiae plasmid maintenance protein ...
 80-220 3.50e-33

forkhead associated (FHA) domain found in Saccharomyces cerevisiae plasmid maintenance protein 2 (PLM2) and similar proteins; This subfamily includes two homologs PLM2 and TOS4 (also called target of SBF protein 4), which are predicted to be chromatin-associated proteins. They bind to the promoters of genes with functions important for the G1/S (start) transition. PLM2 targets primarily genes involved in DNA synthesis and repair, chromosome segregation, nuclear division, and transcription. TOS4 targets primarily genes involved in pheromone response, polarized growth, and transcription. The FHA domain is a small phosphopeptide recognition module.


:

Pssm-ID: 438751 [Multi-domain]  Cd Length: 122  Bit Score: 122.52  E-value: 3.50e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320709   80 SKQEKVLAGPIEIELDASDPSRLAIGRKKSVCNIILPCRKNISRQHAFISYAADRNEIKLECNGTNGLSVHLPYSMQLHL 159
Cdd:cd22699   1 LKSPSSHEATITIVLPSSDTAPVTIGRSSQSCDYISRKNKQISRVHATIQYDPDRNELEITCLGWNGVTVDIPGQLKGYK 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6320709  160 VKPFPTRNfyklvaeepltsqntkqsHGKTLQKNQNFISFVLAKGETVTFPYiQGSFINFT 220
Cdd:cd22699  81 LKVNKTLN------------------LSKELQKDEDFHNFVLDVGERVLFPG-VGSGVIFD 122
 
Name Accession Description Interval E-value
FHA_PLM2-like cd22699
forkhead associated (FHA) domain found in Saccharomyces cerevisiae plasmid maintenance protein ...
 80-220 3.50e-33

forkhead associated (FHA) domain found in Saccharomyces cerevisiae plasmid maintenance protein 2 (PLM2) and similar proteins; This subfamily includes two homologs PLM2 and TOS4 (also called target of SBF protein 4), which are predicted to be chromatin-associated proteins. They bind to the promoters of genes with functions important for the G1/S (start) transition. PLM2 targets primarily genes involved in DNA synthesis and repair, chromosome segregation, nuclear division, and transcription. TOS4 targets primarily genes involved in pheromone response, polarized growth, and transcription. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438751 [Multi-domain]  Cd Length: 122  Bit Score: 122.52  E-value: 3.50e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320709   80 SKQEKVLAGPIEIELDASDPSRLAIGRKKSVCNIILPCRKNISRQHAFISYAADRNEIKLECNGTNGLSVHLPYSMQLHL 159
Cdd:cd22699   1 LKSPSSHEATITIVLPSSDTAPVTIGRSSQSCDYISRKNKQISRVHATIQYDPDRNELEITCLGWNGVTVDIPGQLKGYK 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6320709  160 VKPFPTRNfyklvaeepltsqntkqsHGKTLQKNQNFISFVLAKGETVTFPYiQGSFINFT 220
Cdd:cd22699  81 LKVNKTLN------------------LSKELQKDEDFHNFVLDVGERVLFPG-VGSGVIFD 122
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
 104-149 2.77e-06

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 44.48  E-value: 2.77e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 6320709     104 IGRKKSVCNIILPCRkNISRQHAFISYAADrNEIKLECNG-TNGLSV 149
Cdd:smart00240   3 IGRSSEDCDIQLDGP-SISRRHAVIVYDGG-GRFYLIDLGsTNGTFV 47
 
Name Accession Description Interval E-value
FHA_PLM2-like cd22699
forkhead associated (FHA) domain found in Saccharomyces cerevisiae plasmid maintenance protein ...
 80-220 3.50e-33

forkhead associated (FHA) domain found in Saccharomyces cerevisiae plasmid maintenance protein 2 (PLM2) and similar proteins; This subfamily includes two homologs PLM2 and TOS4 (also called target of SBF protein 4), which are predicted to be chromatin-associated proteins. They bind to the promoters of genes with functions important for the G1/S (start) transition. PLM2 targets primarily genes involved in DNA synthesis and repair, chromosome segregation, nuclear division, and transcription. TOS4 targets primarily genes involved in pheromone response, polarized growth, and transcription. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438751 [Multi-domain]  Cd Length: 122  Bit Score: 122.52  E-value: 3.50e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320709   80 SKQEKVLAGPIEIELDASDPSRLAIGRKKSVCNIILPCRKNISRQHAFISYAADRNEIKLECNGTNGLSVHLPYSMQLHL 159
Cdd:cd22699   1 LKSPSSHEATITIVLPSSDTAPVTIGRSSQSCDYISRKNKQISRVHATIQYDPDRNELEITCLGWNGVTVDIPGQLKGYK 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6320709  160 VKPFPTRNfyklvaeepltsqntkqsHGKTLQKNQNFISFVLAKGETVTFPYiQGSFINFT 220
Cdd:cd22699  81 LKVNKTLN------------------LSKELQKDEDFHNFVLDVGERVLFPG-VGSGVIFD 122
FHA smart00240
Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear ...
 104-149 2.77e-06

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.


Pssm-ID: 214578 [Multi-domain]  Cd Length: 52  Bit Score: 44.48  E-value: 2.77e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 6320709     104 IGRKKSVCNIILPCRkNISRQHAFISYAADrNEIKLECNG-TNGLSV 149
Cdd:smart00240   3 IGRSSEDCDIQLDGP-SISRRHAVIVYDGG-GRFYLIDLGsTNGTFV 47
FHA_FKH1-like cd22701
forkhead associated (FHA) domain found in Saccharomyces cerevisiae fork head protein homolog 1 ...
 119-149 1.56e-04

forkhead associated (FHA) domain found in Saccharomyces cerevisiae fork head protein homolog 1 (FKH1), 2 (FKH2) and similar proteins; This family includes FKH1 and FKH2, as well as pre-rRNA-processing protein FHL1. FKH1 and FKH2 are forkhead transcription factors that regulate the expression of the CLB2 cluster of genes during the G2/M phase of the mitotic cell cycle. The CLB2 cluster of genes includes mitotic regulators such as CLB1, CLB2, CDC5 and CDC20, as well as SWI5 and ACE2. FKH1 and FKH2 are involved in HMRa silencing. They associate with the coding regions of active genes and influence, in opposing ways, transcriptional elongation and termination, and coordinate early transcription elongation and pre-mRNA processing. Both FKH1 and FKH2 play a role as regulators of lifespan in collaboration with the anaphase-promoting complex (APC), likely through combined regulation of stress response, genomic stability, and cell cycle regulation. They also function in controlling yeast cell morphology by preventing pseudohyphal growth and act as rate-limiting replication origin activators via their interaction with the origin recognition complex (ORC). FHL1 is a forkhead protein that controls the pre-rRNA processing machinery in conjunction with IFH1. It might act as a transcriptional regulator of genes specifically involved in that process. IFH1 convert FHL1 from a repressor to an activator. This family also includes AtFHA1 and AtFHA2, which may play a role in the control of plant organ development. AtFHA2 is specifically involved in the regulation of stamen development. The FHA domain is a small phosphopeptide recognition module.


Pssm-ID: 438753 [Multi-domain]  Cd Length: 106  Bit Score: 41.07  E-value: 1.56e-04
                        10        20        30
                ....*....|....*....|....*....|.
gi 6320709  119 KNISRQHAFISYAADRNEIKLECNGTNGLSV 149
Cdd:cd22701  44 KKISRRHARIFYDFTTQCFELSVLGRNGVKV 74
FHA cd00060
forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small ...
 98-149 3.64e-04

forkhead associated (FHA) domain superfamily; Forkhead-associated (FHA) domains are small phosphopeptide recognition modules mostly found in eubacteria and eukaryotes. It is about 95-120 residues long that fold into an 11-stranded beta-sandwich. FHA domains can mediate the recognition of phosphorylated and non-phosphorylated substrates, as well as protein oligomerization. They specifically recognize threonine phosphorylation (pThr) accompanying activation of protein serine/threonine kinases. FHA domains show diverse ligand specificity. They may recognize the pTXXD motif, the pTXXI/L motif, and TQ clusters (singly and multiply phosphorylated). In eukaryotes, FHA superfamily members include forkhead-type transcription factors, as well as other signaling proteins, such as many regulatory proteins, kinases, phosphatases, motor proteins called kinesins, and metabolic enzymes. Many of them localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. FHA domains play important roles in human diseases, particularly in relation to DNA damage responses and cancers. In bacteria, FHA domain-containing proteins may participate in injection of viral proteins into host cells, transmembrane transporters, and cell division. FHA domain-containing proteins rarely include more than one copy of the domain. The only exception in eukaryotes is the checkpoint kinase Rad53 from Saccharomyces cerevisiae, which harbors two FHA domains (FHA1 and FHA2) flanking a central kinase domain. The two FHA domains recognize different phosphorylated targets and function independently from one another. In contrast, Mycobacterium tuberculosis ABC transporter Rv1747 contains two FHA domains but only one of them is essential for protein function.


Pssm-ID: 438714 [Multi-domain]  Cd Length: 92  Bit Score: 39.57  E-value: 3.64e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 6320709   98 DPSRLAIGRKKSvCNIILPCRkNISRQHAFISYaaDRNEIKLE-CNGTNGLSV 149
Cdd:cd00060  17 TKGVVTIGRSPD-CDIVLDDP-SVSRRHARIEV--DGGGVYLEdLGSTNGTFV 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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