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Conserved domains on  [gi|6320739|ref|NP_010819|]
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bifunctional AP-4-A phosphorylase/ADP sulfurylase [Saccharomyces cerevisiae S288C]

Protein Classification

ATP adenylyltransferase family protein( domain architecture ID 1005826)

ATP adenylyltransferase family protein such as fungal diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 2 that catalyzes the phosphorolytic degradation of bis(5'-adenosyl) tetraphosphate (Ap4A) into ADP and ATP; belongs to the HIT (Histidine triad) superfamily

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
APA2 super family cl34755
ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide ...
43-296 5.34e-38

ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism];


The actual alignment was detected with superfamily member COG4360:

Pssm-ID: 443494 [Multi-domain]  Cd Length: 293  Bit Score: 136.57  E-value: 5.34e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320739   43 WVTfapSLALKPDANKN---SDSKAEDPFANPDEELVVtedlnGD-GEYKL-LLNKFPVVPEHSLLVTSEFKDQRSALTP 117
Cdd:COG4360  46 IVS---NLARKDAAKKKqggTRGPDFNPFLPYEPDLFV-----GDiSDTHVcLLNKFNVVDHHLLIVTRAFEEQESLLTL 117
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320739  118 SDlMTAynvLCSLQGDKDDdvtceryLVFYNCGPHSGSSQDHKHLQIMQMP----EKFIPFQDVLCNGKdhflptFNAEP 193
Cdd:COG4360 118 AD-FAA---LAACLAEIDG-------LGFYNGGKIAGASQRHKHLQLVPLPlapdGLAIPIEPALASAQ------FPGSI 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320739  194 LQDDKVSFAH-FV-LPLPESSDQVD--EDLLAmCYVSLMQrALTFFQDWTNESPeltkSYNVLLTKKWICVVPRSHAKSg 269
Cdd:COG4360 181 GTIPSLPFRHaFArLDPDWLSSPLAaaAALLE-AYRRLLQ-ALGLGAGDAQQSP----PYNLLATREWMLIVPRSQESF- 253
                       250       260
                ....*....|....*....|....*..
gi 6320739  270 ppLMLNINSTGYCGMILVKDREKLENL 296
Cdd:COG4360 254 --EGISVNALGFAGSLLVRNPEQLDWL 278
 
Name Accession Description Interval E-value
APA2 COG4360
ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide ...
43-296 5.34e-38

ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism];


Pssm-ID: 443494 [Multi-domain]  Cd Length: 293  Bit Score: 136.57  E-value: 5.34e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320739   43 WVTfapSLALKPDANKN---SDSKAEDPFANPDEELVVtedlnGD-GEYKL-LLNKFPVVPEHSLLVTSEFKDQRSALTP 117
Cdd:COG4360  46 IVS---NLARKDAAKKKqggTRGPDFNPFLPYEPDLFV-----GDiSDTHVcLLNKFNVVDHHLLIVTRAFEEQESLLTL 117
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320739  118 SDlMTAynvLCSLQGDKDDdvtceryLVFYNCGPHSGSSQDHKHLQIMQMP----EKFIPFQDVLCNGKdhflptFNAEP 193
Cdd:COG4360 118 AD-FAA---LAACLAEIDG-------LGFYNGGKIAGASQRHKHLQLVPLPlapdGLAIPIEPALASAQ------FPGSI 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320739  194 LQDDKVSFAH-FV-LPLPESSDQVD--EDLLAmCYVSLMQrALTFFQDWTNESPeltkSYNVLLTKKWICVVPRSHAKSg 269
Cdd:COG4360 181 GTIPSLPFRHaFArLDPDWLSSPLAaaAALLE-AYRRLLQ-ALGLGAGDAQQSP----PYNLLATREWMLIVPRSQESF- 253
                       250       260
                ....*....|....*....|....*..
gi 6320739  270 ppLMLNINSTGYCGMILVKDREKLENL 296
Cdd:COG4360 254 --EGISVNALGFAGSLLVRNPEQLDWL 278
ATP_transf pfam09830
ATP adenylyltransferase C-terminal domain; Members of this family of proteins catabolize Ap4N ...
198-313 1.50e-33

ATP adenylyltransferase C-terminal domain; Members of this family of proteins catabolize Ap4N nucleotides (where N is A,C,G or U). Additionally they catalyze the conversion of adenosine-5-phosphosulfate (AMPs) plus Pi to ADP plus sulphate, the exchange of NDP and phosphate and the synthesis of Ap4A from AMPs plus ATP.


Pssm-ID: 430861  Cd Length: 103  Bit Score: 119.24  E-value: 1.50e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320739    198 KVSFAHFVLPLPesSDQVDEDLLAMCYVSLMQRA-LTFFQDwtnespelTKSYNVLLTKKWICVVPRSHAKSGPplmLNI 276
Cdd:pfam09830   2 KLPFAHFVLRPK--SEDESAEELLEAYLSLLRRAkLAVGGD--------AISYNLLMTREWMLVIPRSSEGSGG---ISV 68
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 6320739    277 NSTGYCGMILVKDREKLENLTEDPHLvdKSLLQCGFP 313
Cdd:pfam09830  69 NALGFAGLLLVKSEEELDALKELGPL--KILAEVGVP 103
 
Name Accession Description Interval E-value
APA2 COG4360
ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide ...
43-296 5.34e-38

ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism];


Pssm-ID: 443494 [Multi-domain]  Cd Length: 293  Bit Score: 136.57  E-value: 5.34e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320739   43 WVTfapSLALKPDANKN---SDSKAEDPFANPDEELVVtedlnGD-GEYKL-LLNKFPVVPEHSLLVTSEFKDQRSALTP 117
Cdd:COG4360  46 IVS---NLARKDAAKKKqggTRGPDFNPFLPYEPDLFV-----GDiSDTHVcLLNKFNVVDHHLLIVTRAFEEQESLLTL 117
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320739  118 SDlMTAynvLCSLQGDKDDdvtceryLVFYNCGPHSGSSQDHKHLQIMQMP----EKFIPFQDVLCNGKdhflptFNAEP 193
Cdd:COG4360 118 AD-FAA---LAACLAEIDG-------LGFYNGGKIAGASQRHKHLQLVPLPlapdGLAIPIEPALASAQ------FPGSI 180
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320739  194 LQDDKVSFAH-FV-LPLPESSDQVD--EDLLAmCYVSLMQrALTFFQDWTNESPeltkSYNVLLTKKWICVVPRSHAKSg 269
Cdd:COG4360 181 GTIPSLPFRHaFArLDPDWLSSPLAaaAALLE-AYRRLLQ-ALGLGAGDAQQSP----PYNLLATREWMLIVPRSQESF- 253
                       250       260
                ....*....|....*....|....*..
gi 6320739  270 ppLMLNINSTGYCGMILVKDREKLENL 296
Cdd:COG4360 254 --EGISVNALGFAGSLLVRNPEQLDWL 278
ATP_transf pfam09830
ATP adenylyltransferase C-terminal domain; Members of this family of proteins catabolize Ap4N ...
198-313 1.50e-33

ATP adenylyltransferase C-terminal domain; Members of this family of proteins catabolize Ap4N nucleotides (where N is A,C,G or U). Additionally they catalyze the conversion of adenosine-5-phosphosulfate (AMPs) plus Pi to ADP plus sulphate, the exchange of NDP and phosphate and the synthesis of Ap4A from AMPs plus ATP.


Pssm-ID: 430861  Cd Length: 103  Bit Score: 119.24  E-value: 1.50e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320739    198 KVSFAHFVLPLPesSDQVDEDLLAMCYVSLMQRA-LTFFQDwtnespelTKSYNVLLTKKWICVVPRSHAKSGPplmLNI 276
Cdd:pfam09830   2 KLPFAHFVLRPK--SEDESAEELLEAYLSLLRRAkLAVGGD--------AISYNLLMTREWMLVIPRSSEGSGG---ISV 68
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 6320739    277 NSTGYCGMILVKDREKLENLTEDPHLvdKSLLQCGFP 313
Cdd:pfam09830  69 NALGFAGLLLVKSEEELDALKELGPL--KILAEVGVP 103
Ap4A_phos_N pfam19327
Ap4A phosphorylase N-terminal domain; This entry represents the N-terminal HIT-like domain ...
49-168 2.89e-19

Ap4A phosphorylase N-terminal domain; This entry represents the N-terminal HIT-like domain from the Ap4A phosphorylase enzyme.


Pssm-ID: 437159  Cd Length: 179  Bit Score: 83.74  E-value: 2.89e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320739     49 SLALKPDANKNSD------SKAEDPFANPDEELVVTeDLNGDgeYKLLLNKFPVVPEHSLLVTSEFKDQRSALTPSDlMT 122
Cdd:pfam19327  52 NLARKDAAKKQQDkqtaktGKEFNPFLPYEPDLFVA-DISDT--HVCLLNKFNVVDHHLLIVTRAFEEQESLLTLAD-FE 127
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 6320739    123 AYNvLCSLQGDKdddvtceryLVFYNCGPHSGSSQDHKHLQIMQMP 168
Cdd:pfam19327 128 ALW-ACLAEIDG---------LGFYNGGKIAGASQRHKHLQLVPLP 163
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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