|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09259 |
PRK09259 |
putative oxalyl-CoA decarboxylase; Validated |
13-544 |
2.49e-125 |
|
putative oxalyl-CoA decarboxylase; Validated
Pssm-ID: 236433 [Multi-domain] Cd Length: 569 Bit Score: 379.33 E-value: 2.49e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 13 LQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSMSNRW 92
Cdd:PRK09259 20 LKLNGIDTIYGVVGIPITDLARLAQAEGIRYIGFRHEQSAGNAAAAAGFLTQKPGVCLTVSAPGFLNGLTALANATTNCF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 93 PLLVIAGSSSQS--DIHKGGFQELDQVSLLSPFLKFTGK-LTPDNIDMITQKALNYCIQGTAGVSYIDVPADFIEYEKPL 169
Cdd:PRK09259 100 PMIMISGSSEREivDLQQGDYEELDQLNAAKPFCKAAFRvNRAEDIGIGVARAIRTAVSGRPGGVYLDLPAKVLAQTMDA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 170 EGNDRT----GNELPMILtpnicgPDPSKIKKVVQLILQHKNKniLIVIGKGAV--KNSHEIRRLVNTFNLPFLPTPMAK 243
Cdd:PRK09259 180 DEALTSlvkvVDPAPAQL------PAPEAVDRALDLLKKAKRP--LIILGKGAAyaQADEQIREFVEKTGIPFLPMSMAK 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 244 GIVPDSSPLNVSSARSQALKIADIVLVLGARLNWILHFGTSPKWNSESIFIQFDSNPETLgDNNVSPGADLSiwGDIGLS 323
Cdd:PRK09259 252 GLLPDTHPQSAAAARSLALANADVVLLVGARLNWLLSHGKGKTWGADKKFIQIDIEPQEI-DSNRPIAAPVV--GDIGSV 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 324 VTALVEELTRQ----DSCWkysgvKQEIREKIQLNQTRLLRKEKTRGAQLNYNQVYGTLRPLIDDYR-TILVTEGANTMD 398
Cdd:PRK09259 329 MQALLAGLKQNtfkaPAEW-----LDALAERKEKNAAKMAEKLSTDTQPMNFYNALGAIRDVLKENPdIYLVNEGANTLD 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 399 IARISFPTDAPRRRLDAGTNATMGIGLGYAL--ACKASHPeldVVLIQGDSAFGFSAMEIETAVRCQLALVIVVMNNSGI 476
Cdd:PRK09259 404 LARNIIDMYKPRHRLDCGTWGVMGIGMGYAIaaAVETGKP---VVAIEGDSAFGFSGMEVETICRYNLPVTVVIFNNGGI 480
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6320816 477 YHG-EKDIEG--DLPPTALSKNCRYDLVGKGLGANDFFVNTISELSRCFQQAVQLSRtkreTSVINVIIEP 544
Cdd:PRK09259 481 YRGdDVNLSGagDPSPTVLVHHARYDKMMEAFGGVGYNVTTPDELRHALTEAIASGK----PTLINVVIDP 547
|
|
| IlvB |
COG0028 |
Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme [Amino ... |
1-546 |
9.87e-106 |
|
Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439799 [Multi-domain] Cd Length: 548 Bit Score: 328.27 E-value: 9.87e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 1 MTTTATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVAN-GIKFIPCRNEQAasyaasayGY--ISDKPGVLLIVGGPGL 77
Cdd:COG0028 1 MKMTGADALVEALEAEGVETVFGVPGGAILPLYDALRRQsGIRHILVRHEQGaaf--madGYarATGKPGVCLVTSGPGA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 78 IHALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYI 156
Cdd:COG0028 79 TNLVTGLADAYMDSVPVLAITGQVPTSLIGRGAFQEVDQVGLFRPITKWSYLVTdPEDLPEVLRRAFRIATSGRPGPVVL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 157 DVPADF----IEYEKPlegndrtgnELPMILTPNICGPDPSKIKKVVQLILQHknKNILIVIGKGAVKN--SHEIRRLVN 230
Cdd:COG0028 159 DIPKDVqaaeAEEEPA---------PPELRGYRPRPAPDPEAIEEAAELLAAA--KRPVILAGGGARRAgaAEELRALAE 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 231 TFNLPFLPTPMAKGIVPDSSPLNV-------SSARSQALKIADIVLVLGARLNWILHFGTSPkWNSESIFIQFDSNPETL 303
Cdd:COG0028 228 RLGAPVVTTLMGKGAFPEDHPLYLgmlgmhgTPAANEALAEADLVLAVGARFDDRVTGNWDE-FAPDAKIIHIDIDPAEI 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 304 GdNNVSPgaDLSIWGDIGLSVTALVEELTRQDScwkysgVKQEIREKIQLNQTRLLRKEKTRGAQLNYNQVYGTLRPLID 383
Cdd:COG0028 307 G-KNYPV--DLPIVGDAKAVLAALLEALEPRAD------DRAAWLARIAAWRAEYLAAYAADDGPIKPQRVIAALREALP 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 384 DyRTILVTE-GANTMDIARIsFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRC 462
Cdd:COG0028 378 D-DAIVVTDvGQHQMWAARY-LRFRRPRRFLTSGGLGTMGYGLPAAIGAKLARPDRPVVAITGDGGFQMNLQELATAVRY 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 463 QLALVIVVMNNSG---IYHGEKDIEGDLPPTALSKNCRYDLVGKGLGANDFFVNTISELSRCFQQAVQlsrtKRETSVIN 539
Cdd:COG0028 456 GLPVKVVVLNNGGlgmVRQWQELFYGGRYSGTDLPNPDFAKLAEAFGAKGERVETPEELEAALEEALA----SDGPALID 531
|
....*..
gi 6320816 540 VIIEPGE 546
Cdd:COG0028 532 VRVDPEE 538
|
|
| TPP_BZL_OCoD_HPCL |
cd02004 |
Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of ... |
371-543 |
2.14e-74 |
|
Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL cleaves the acyloin linkage of benzoin producing 2 molecules of benzaldehyde and enabling the Pseudomonas to grow on benzoin as the sole carbon and energy source. OCoD has a role in the detoxification of oxalate, catalyzing the decarboxylation of oxalyl-CoA to formate. 2-HPCL is a peroxisomal enzyme which plays a role in the alpha-oxidation of 3-methyl-branched fatty acids, catalyzing the cleavage of 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde. All these enzymes depend on Mg2+ and TPP for activity.
Pssm-ID: 238962 [Multi-domain] Cd Length: 172 Bit Score: 233.96 E-value: 2.14e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 371 YNQVYGTLRPLIDDyRTILVTEGANTMDIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFG 450
Cdd:cd02004 1 PYRVLHELQEALPD-DAIIVSDGGNTMDWARYILRPRKPRHRLDAGTFGTLGVGLGYAIAAALARPDKRVVLVEGDGAFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 451 FSAMEIETAVRCQLALVIVVMNNSGIYHGEKD----IEGDLPPTALSKNCRYDLVGKGLGANDFFVNTISELSRCFQQAV 526
Cdd:cd02004 80 FSGMELETAVRYNLPIVVVVGNNGGWYQGLDGqqlsYGLGLPVTTLLPDTRYDLVAEAFGGKGELVTTPEELKPALKRAL 159
|
170
....*....|....*..
gi 6320816 527 QLSRtkreTSVINVIIE 543
Cdd:cd02004 160 ASGK----PALINVIID 172
|
|
| PRK05858 |
PRK05858 |
acetolactate synthase; |
5-544 |
1.27e-60 |
|
acetolactate synthase;
Pssm-ID: 235629 [Multi-domain] Cd Length: 542 Bit Score: 209.58 E-value: 1.27e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 5 ATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGI 84
Cdd:PRK05858 7 AGRLAARRLKAHGVDTMFTLSGGHLFPLYDGAREEGIRLIDVRHEQTAAFAAEAWAKLTRVPGVAVLTAGPGVTNGMSAM 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 85 YNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKF--TGkLTPDNIDMITQKALNYCIQGTAGVSYIDVPADf 162
Cdd:PRK05858 87 AAAQFNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAPVTKFaaTA-QSAENAGRLVDQALQAAVTPHRGPVFVDFPMD- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 163 iEYEKPLEGNDRTGnelPMILTPNICGPDPSKIKKVVQLILQHKNKniLIVIGKGAVKNSHE--IRRLVNTFNLPFLPTP 240
Cdd:PRK05858 165 -HAFSMADDDGRPG---ALTELPAGPTPDPDALARAAGLLAEAQRP--VIMAGTDVWWGHAEaaLLRLAEELGIPVLMNG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 241 MAKGIVPDSSPLNVSSARSQALKIADIVLVLGARLNWILHFGTspkWNSESIFIQFDSNPETLgDNNVSPGADLSiwGDI 320
Cdd:PRK05858 239 MGRGVVPADHPLAFSRARGKALGEADVVLVVGVPMDFRLGFGV---FGGTAQLVHVDDAPPQR-AHHRPVAAGLY--GDL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 321 GLSVTALVEEltrqdscWKYSGVKQEIREKIQLNQTRLLRKEKTRGAQ----LNYNQVYGTLRPLIDDyRTILVTEGANT 396
Cdd:PRK05858 313 SAILSALAGA-------GGDRTDHQGWIEELRTAETAARARDAAELADdrdpIHPMRVYGELAPLLDR-DAIVIGDGGDF 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 397 MDIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVIVVMNNsGI 476
Cdd:PRK05858 385 VSYAGRYIDPYRPGCWLDPGPFGCLGTGPGYALAARLARPSRQVVLLQGDGAFGFSLMDVDTLVRHNLPVVSVIGNN-GI 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 477 YHGEK---------DIEGDLPPtalskNCRYDLVGKGLGANDFFVNTISE----LSRCFQQAVqlsrtkreTSVINVIIE 543
Cdd:PRK05858 464 WGLEKhpmealygyDVAADLRP-----GTRYDEVVRALGGHGELVTVPAElgpaLERAFASGV--------PYLVNVLTD 530
|
.
gi 6320816 544 P 544
Cdd:PRK05858 531 P 531
|
|
| PRK08266 |
PRK08266 |
hypothetical protein; Provisional |
1-474 |
1.16e-45 |
|
hypothetical protein; Provisional
Pssm-ID: 181337 [Multi-domain] Cd Length: 542 Bit Score: 168.65 E-value: 1.16e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 1 MTTTATQHFAQLLQKYGIDTVFGIVGIPIVQLADTM--VANGIKFIPCRNEQAASYAASayGY--ISDKPGVLLIVGGPG 76
Cdd:PRK08266 2 TTMTGGEAIVAGLVAHGVDTVFGLPGAQLYWLFDALykAGDRIRVIHTRHEQAAGYMAF--GYarSTGRPGVCSVVPGPG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 77 LIHALAGIYNSMSNRWPLLVIAGSSSQSDIHKG-GF-QEL-DQVSLLSPFLKFTGK-LTPDNIDMITQKALNYCIQGTAG 152
Cdd:PRK08266 80 VLNAGAALLTAYGCNSPVLCLTGQIPSALIGKGrGHlHEMpDQLATLRSFTKWAERiEHPSEAPALVAEAFQQMLSGRPR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 153 VSYIDVPADFIEyekplegndRTGNELPMILTPNICGP--DPSKIKKVVQLILQHKNKniLIVIGKGAVKNSHEIRRLVN 230
Cdd:PRK08266 160 PVALEMPWDVFG---------QRAPVAAAPPLRPAPPPapDPDAIAAAAALIAAAKNP--MIFVGGGAAGAGEEIRELAE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 231 TFNLPFLPTPMAKGIVPDSSPLNVSSARSQAL-KIADIVLVLGARLnwILHFGTSPKWNSESIFIQFDSNPETlgdnNVS 309
Cdd:PRK08266 229 MLQAPVVAFRSGRGIVSDRHPLGLNFAAAYELwPQTDVVIGIGSRL--ELPTFRWPWRPDGLKVIRIDIDPTE----MRR 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 310 PGADLSIWGDIGLSVTALVEELTRQDScwKYSGVKQEIREKIQLNQTRLLRKEktrgAQLNYNQVygtLRP-LIDDyrTI 388
Cdd:PRK08266 303 LKPDVAIVADAKAGTAALLDALSKAGS--KRPSRRAELRELKAAARQRIQAVQ----PQASYLRA---IREaLPDD--GI 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 389 LVTEGANTMDIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVI 468
Cdd:PRK08266 372 FVDELSQVGFASWFAFPVYAPRTFVTCGYQGTLGYGFPTALGAKVANPDRPVVSITGDGGFMFGVQELATAVQHNIGVVT 451
|
....*.
gi 6320816 469 VVMNNS 474
Cdd:PRK08266 452 VVFNNN 457
|
|
| PRK08611 |
PRK08611 |
pyruvate oxidase; Provisional |
1-546 |
5.64e-45 |
|
pyruvate oxidase; Provisional
Pssm-ID: 181502 [Multi-domain] Cd Length: 576 Bit Score: 167.49 E-value: 5.64e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 1 MTTTATQHFAQLLQKYGIDTVFGIVGIPIVQLADTM--VANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLI 78
Cdd:PRK08611 2 AKIKAGEALVKLLQDWGIDHVYGIPGDSIDAVVDALrkEQDKIKFIQVRHEEVAALAAAAYAKLTGKIGVCLSIGGPGAI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 79 HALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKL-TPDNIDMITQKALNyciqgTA----GV 153
Cdd:PRK08611 82 HLLNGLYDAKMDHVPVLALAGQVTSDLLGTDFFQEVNLEKMFEDVAVYNHQImSAENLPEIVNQAIR-----TAyekkGV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 154 SYIDVPADFieyekPLEGNDRTGNELPMILTPNICGPDPSKIKKVVQLIlqHKNKNILIVIGKGAVKNSHEIRRLVNTFN 233
Cdd:PRK08611 157 AVLTIPDDL-----PAQKIKDTTNKTVDTFRPTVPSPKPKDIKKAAKLI--NKAKKPVILAGLGAKHAKEELLAFAEKAK 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 234 LPFLPTPMAKGIVPDSSPLNV-------SSARSQALKIADIVLVLgarlnwilhfGTS-------PKwnsESIFIQFDSN 299
Cdd:PRK08611 230 IPIIHTLPAKGIIPDDHPYSLgnlgkigTKPAYEAMQEADLLIMV----------GTNypyvdylPK---KAKAIQIDTD 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 300 PETLGDN-NVSPGadlsIWGDIGLSVTALVEELTRQD------SCWKYSGVKQEIREKIQLNQTRLLRKEktrgaqlnyn 372
Cdd:PRK08611 297 PANIGKRyPVNVG----LVGDAKKALHQLTENIKHVEdrrfleACQENMAKWWKWMEEDENNASTPIKPE---------- 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 373 QVYGTLRPLIDDYRTILVTEGANTMDIArisfptdaprRRLDAGTN---------ATMGIGLGYALACKASHPELDVVLI 443
Cdd:PRK08611 363 RVMAAIQKIADDDAVLSVDVGTVTVWSA----------RYLNLGTNqkfiisswlGTMGCGLPGAIAAKIAFPDRQAIAI 432
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 444 QGDSAFGFSAMEIETAVRCQLALVIVVMNNSGI----YH----GEKDIEGDLPPTALSK---NCRydlvGKGlgandFFV 512
Cdd:PRK08611 433 CGDGGFSMVMQDFVTAVKYKLPIVVVVLNNQQLafikYEqqaaGELEYAIDLSDMDYAKfaeACG----GKG-----YRV 503
|
570 580 590
....*....|....*....|....*....|....
gi 6320816 513 NTISELSRCFQQAVQLSRtkreTSVINVIIEPGE 546
Cdd:PRK08611 504 EKAEELDPAFEEALAQDK----PVIIDVYVDPNA 533
|
|
| PRK08617 |
PRK08617 |
acetolactate synthase AlsS; |
3-475 |
3.19e-44 |
|
acetolactate synthase AlsS;
Pssm-ID: 236312 [Multi-domain] Cd Length: 552 Bit Score: 165.03 E-value: 3.19e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 3 TTATQHFAQL----LQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLI 78
Cdd:PRK08617 1 TDKKKYGADLvvdsLINQGVKYVFGIPGAKIDRVFDALEDSGPELIVTRHEQNAAFMAAAIGRLTGKPGVVLVTSGPGVS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 79 HALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYID 157
Cdd:PRK08617 81 NLATGLVTATAEGDPVVAIGGQVKRADRLKRTHQSMDNVALFRPITKYSAEVQdPDNLSEVLANAFRAAESGRPGAAFVS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 158 VPADFIeyEKPLegndrTGNELPMILTPNICGPDPSKIKKVVQLILQHKNKNILIVIGKGAVKNSHEIRRLVNTFNLPFL 237
Cdd:PRK08617 161 LPQDVV--DAPV-----TSKAIAPLSKPKLGPASPEDINYLAELIKNAKLPVLLLGMRASSPEVTAAIRRLLERTNLPVV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 238 PTPMAKGIVpdSSPL------NVSSARSQA----LKIADIVLVLG-------ARLnwilhfgtspkWNSE--SIFIQFDS 298
Cdd:PRK08617 234 ETFQAAGVI--SRELedhffgRVGLFRNQPgdelLKKADLVITIGydpieyePRN-----------WNSEgdATIIHIDV 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 299 NPETLgDNNVSPgaDLSIWGDIGLSVTALVEELTRqdscWKYSGVKQEIREKIQlnqtRLLRKEKTRGAQLNYN-----Q 373
Cdd:PRK08617 301 LPAEI-DNYYQP--ERELIGDIAATLDLLAEKLDG----LSLSPQSLEILEELR----AQLEELAERPARLEEGavhplR 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 374 VYGTLRPLIDDYRTILVTEGANTMDIARiSFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSA 453
Cdd:PRK08617 370 IIRALQDIVTDDTTVTVDVGSHYIWMAR-YFRSYEPRHLLFSNGMQTLGVALPWAIAAALVRPGKKVVSVSGDGGFLFSA 448
|
490 500
....*....|....*....|..
gi 6320816 454 MEIETAVRCQLALVIVVMNNSG 475
Cdd:PRK08617 449 MELETAVRLKLNIVHIIWNDGH 470
|
|
| PRK08322 |
PRK08322 |
acetolactate synthase large subunit; |
4-475 |
5.06e-44 |
|
acetolactate synthase large subunit;
Pssm-ID: 236239 [Multi-domain] Cd Length: 547 Bit Score: 164.23 E-value: 5.06e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 4 TATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAG 83
Cdd:PRK08322 2 KAADLFVKCLENEGVEYIFGIPGEENLDLLEALRDSSIKLILTRHEQGAAFMAATYGRLTGKAGVCLSTLGPGATNLVTG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 84 IYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGK-LTPDNIDMITQKALNYCIQGTAGVSYIDVPADF 162
Cdd:PRK08322 82 VAYAQLGGMPMVAITGQKPIKRSKQGSFQIVDVVAMMAPLTKWTRQiVSPDNIPEVVREAFRLAEEERPGAVHLELPEDI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 163 IEYE---KPLEgndRTGNELPMiltpnicgPDPSKIKKVVQLIlqHKNKNILIVIGKGAVKN--SHEIRRLVNTFNLPFL 237
Cdd:PRK08322 162 AAEEtdgKPLP---RSYSRRPY--------ASPKAIERAAEAI--QAAKNPLILIGAGANRKtaSKALTEFVDKTGIPFF 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 238 PTPMAKGIVPDSSPLNVSSARSQ-------ALKIADIVLVLGARLnwiLHFgtSP-KWNSES----IFIQFDSNPEtlgD 305
Cdd:PRK08322 229 TTQMGKGVIPETHPLSLGTAGLSqgdyvhcAIEHADLIINVGHDV---IEK--PPfFMNPNGdkkvIHINFLPAEV---D 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 306 NNVSPgaDLSIWGDIGLSVTALVEELTRQDScWKYSGVKqEIREKIqlnqtrllRKEKTRGAQLNYNQVYgtlrP--LID 383
Cdd:PRK08322 301 PVYFP--QVEVVGDIANSLWQLKERLADQPH-WDFPRFL-KIREAI--------EAHLEEGADDDRFPMK----PqrIVA 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 384 DYRT-------ILVTEGANTMDIARiSFPTDAPRRRL-DAGTnATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAME 455
Cdd:PRK08322 365 DLRKvmpdddiVILDNGAYKIWFAR-NYRAYEPNTCLlDNAL-ATMGAGLPSAIAAKLVHPDRKVLAVCGDGGFMMNSQE 442
|
490 500
....*....|....*....|
gi 6320816 456 IETAVRCQLALVIVVMNNSG 475
Cdd:PRK08322 443 LETAVRLGLPLVVLILNDNA 462
|
|
| acolac_lg |
TIGR00118 |
acetolactate synthase, large subunit, biosynthetic type; Two groups of proteins form ... |
4-473 |
3.06e-43 |
|
acetolactate synthase, large subunit, biosynthetic type; Two groups of proteins form acetolactate from two molecules of pyruvate. The type of acetolactate synthase described in this model also catalyzes the formation of acetohydroxybutyrate from pyruvate and 2-oxobutyrate, an early step in the branched chain amino acid biosynthesis; it is therefore also termed acetohydroxyacid synthase. In bacteria, this catalytic chain is associated with a smaller regulatory chain in an alpha2/beta2 heterotetramer. Acetolactate synthase is a thiamine pyrophosphate enzyme. In this type, FAD and Mg++ are also found. Several isozymes of this enzyme are found in E. coli K12, one of which contains a frameshift in the large subunit gene and is not expressed. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 272915 [Multi-domain] Cd Length: 558 Bit Score: 162.20 E-value: 3.06e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 4 TATQHFAQLLQKYGIDTVFGIVGIPIVQLADTM-VANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALA 82
Cdd:TIGR00118 2 SGAEAIIESLKDEGVKTVFGYPGGAILPIYDALyNDSGIEHILVRHEQGAAHAADGYARASGKVGVVLVTSGPGATNLVT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 83 GIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYIDVPAD 161
Cdd:TIGR00118 82 GIATAYMDSIPMVVFTGQVPTSLIGSDAFQEADILGITMPITKHSFQVKsAEDIPRIIKEAFHIATTGRPGPVLVDLPKD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 162 F----IEYEKPLEGNDRTGNelpmiltPNICGpDPSKIKKVVQLILQHKNKniLIVIGKGAV--KNSHEIRRLVNTFNLP 235
Cdd:TIGR00118 162 VttaeIEYPYPEKVNLPGYR-------PTVKG-HPLQIKKAAELINLAKKP--VILVGGGVIiaGASEELKELAERIQIP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 236 FLPTPMAKGIVPDSSPLNV-------SSARSQALKIADIVLVLGARL-----NWILHFGTSPKwnsesiFIQFDSNPETL 303
Cdd:TIGR00118 232 VTTTLMGLGSFPEDHPLSLgmlgmhgTKTANLAVHECDLIIAVGARFddrvtGNLAKFAPNAK------IIHIDIDPAEI 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 304 GDNnvsPGADLSIWGD----IGLSVTALVEELTRQDSCWkysgvKQEIREKIQLNQTRLLRKEKTRGAQlnynQVYGTLR 379
Cdd:TIGR00118 306 GKN---VRVDIPIVGDarnvLEELLKKLFELKERKESAW-----LEQINKWKKEYPLKMDYTEEGIKPQ----QVIEELS 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 380 PLIDDyRTILVTE-GANTMDIARIsFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIET 458
Cdd:TIGR00118 374 RVTKD-EAIVTTDvGQHQMWAAQF-YPFRKPRRFITSGGLGTMGFGLPAAIGAKVAKPESTVICITGDGSFQMNLQELST 451
|
490
....*....|....*
gi 6320816 459 AVRCQLALVIVVMNN 473
Cdd:TIGR00118 452 AVQYDIPVKILILNN 466
|
|
| sulphoacet_xsc |
TIGR03457 |
sulfoacetaldehyde acetyltransferase; Members of this protein family are sulfoacetaldehyde ... |
4-542 |
2.67e-42 |
|
sulfoacetaldehyde acetyltransferase; Members of this protein family are sulfoacetaldehyde acetyltransferase, an enzyme of taurine utilization. Taurine, or 2-aminoethanesulfonate, can be used by bacteria as a source of carbon, nitrogen, and sulfur. [Central intermediary metabolism, Other]
Pssm-ID: 132497 [Multi-domain] Cd Length: 579 Bit Score: 160.03 E-value: 2.67e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 4 TATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAG 83
Cdd:TIGR03457 3 TPSEAFVEVLVANGVTHAFGIMGSAFMDAMDLFPPAGIRFIPVVHEQGAGHMADGFARVTGRMSMVIGQNGPGVTNCVTA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 84 IYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTaGVSYIDVPADF 162
Cdd:TIGR03457 83 IAAAYWAHTPVVIVTPEAGTKTIGLGGFQEADQLPMFQEFTKYQGHVRhPSRMAEVLNRCFERAWREM-GPAQLNIPRDY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 163 IeYEKPLEgndrtgnELPMIlTPNICGP-DPSKIKKVVQLILQHKNKniLIVIGKGAVKNS--HEIRRLVNTFNLPFLPT 239
Cdd:TIGR03457 162 F-YGEIDV-------EIPRP-VRLDRGAgGATSLAQAARLLAEAKFP--VIISGGGVVMGDavEECKALAERLGAPVVNS 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 240 PMAKGIVPDSSPLNV-------SSARSQALKIADIVLVLGARLNwilHFGTSPK-----WNSESIFIQFDSNPETLG-DN 306
Cdd:TIGR03457 231 YLHNDSFPASHPLWVgplgyqgSKAAMKLISDADVVLALGTRLG---PFGTLPQygidyWPKNAKIIQVDANAKMIGlVK 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 307 NVSPGadlsIWGDIGLSVTALVEELTRqdscwKYSGVKQEIR-EKIQLNQTRLLRK-------------------EKTRG 366
Cdd:TIGR03457 308 KVTVG----ICGDAKAAAAEILQRLAG-----KAGDANRAERkAKIQAERSAWEQElsemtherdpfsldmiveqRQEEG 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 367 AQLNYNQVYGTLRPLIDDyRTILVTEGANTMDIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGD 446
Cdd:TIGR03457 379 NWLHPRQVLRELEKAMPE-DAIVSTDIGNINSVANSYLRFEKPRKFLAPMSFGNCGYAFPTIIGAKIAAPDRPVVAYAGD 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 447 SAFGFSAMEIETAVRCQLALVIVVMNNSGiYHGEKDIEGD-----LPPTALSKNCRYDLVGKGLGANDFFVNTISELSRC 521
Cdd:TIGR03457 458 GAWGMSMNEIMTAVRHDIPVTAVVFRNRQ-WGAEKKNQVDfynnrFVGTELESELSFAGIADAMGAKGVVVDKPEDVGPA 536
|
570 580
....*....|....*....|.
gi 6320816 522 FQQAVQlSRTKRETSVINVII 542
Cdd:TIGR03457 537 LKKAIA-AQAEGKTTVIEIVC 556
|
|
| PRK07525 |
PRK07525 |
sulfoacetaldehyde acetyltransferase; Validated |
1-542 |
2.72e-39 |
|
sulfoacetaldehyde acetyltransferase; Validated
Pssm-ID: 236042 [Multi-domain] Cd Length: 588 Bit Score: 151.30 E-value: 2.72e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 1 MTTTATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHA 80
Cdd:PRK07525 4 MKMTPSEAFVETLQAHGITHAFGIIGSAFMDASDLFPPAGIRFIDVAHEQNAGHMADGYTRVTGRMGMVIGQNGPGITNF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 81 LAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSyIDVP 159
Cdd:PRK07525 84 VTAVATAYWAHTPVVLVTPQAGTKTIGQGGFQEAEQMPMFEDMTKYQEEVRdPSRMAEVLNRVFDKAKRESGPAQ-INIP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 160 ADFIeyekplegndrTG---NELPMILTPNICGPDPSKIKKVVQLILQHKNKNIL----IVIGkGAVKnshEIRRLVNTF 232
Cdd:PRK07525 163 RDYF-----------YGvidVEIPQPVRLERGAGGEQSLAEAAELLSEAKFPVILsgagVVLS-DAIE---ECKALAERL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 233 NLPFLPTPMAKGIVPDSSPL-------NVSSARSQALKIADIVLVLGARLNwilHFGTSPK-----WNSESIFIQFDSNP 300
Cdd:PRK07525 228 DAPVACGYLHNDAFPGSHPLwvgplgyNGSKAAMELIAKADVVLALGTRLN---PFGTLPQygidyWPKDAKIIQVDINP 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 301 ETLGdnnVSPGADLSIWGDIGLSVTALVEELTRQDSCwkySGVKQEIREKIQLNQTR----------------LLRKEKT 364
Cdd:PRK07525 305 DRIG---LTKKVSVGICGDAKAVARELLARLAERLAG---DAGREERKALIAAEKSAweqelsswdhedddpgTDWNEEA 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 365 RGAQLNY---NQVYGTLRPLIDDyRTILVTEGANTMDIARiSFPT-DAPRRRLDAGTNATMGIGLGYALACKASHPELDV 440
Cdd:PRK07525 379 RARKPDYmhpRQALREIQKALPE-DAIVSTDIGNNCSIAN-SYLRfEKGRKYLAPGSFGNCGYAFPAIIGAKIACPDRPV 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 441 VLIQGDSAFGFSAMEIETAVRCQLALVIVVMNNsGIYHGEKD----------IEGDLPPtalskNCRYDLVGKGLGANDF 510
Cdd:PRK07525 457 VGFAGDGAWGISMNEVMTAVRHNWPVTAVVFRN-YQWGAEKKnqvdfynnrfVGTELDN-----NVSYAGIAEAMGAEGV 530
|
570 580 590
....*....|....*....|....*....|..
gi 6320816 511 FVNTISELSRCFQQAVQlSRTKRETSVINVII 542
Cdd:PRK07525 531 VVDTQEELGPALKRAID-AQNEGKTTVIEIMC 561
|
|
| TPP_PYR_POX_like |
cd07035 |
Pyrimidine (PYR) binding domain of POX and related proteins; Thiamine pyrophosphate (TPP ... |
7-160 |
3.58e-39 |
|
Pyrimidine (PYR) binding domain of POX and related proteins; Thiamine pyrophosphate (TPP family), pyrimidine (PYR) binding domain of pyruvate oxidase (POX) and related protiens subfamily. The PYR domain is found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. TPP binds in the cleft formed by a PYR domain and a PP domain. The PYR domain, binds the aminopyrimidine ring of TPP, the PP domain binds the diphosphate residue. A polar interaction between the conserved glutamate of the PYR domain and the N1' of the TPP aminopyrimidine ring is shared by most TPP-dependent enzymes, and participates in the activation of TPP. For glyoxylate carboligase, which belongs to this subfamily, but lacks this conserved glutamate, the rate of the initial TPP activation step is reduced but the ensuing steps of the enzymic reaction proceed efficiently. The PYR and PP domains have a common fold, but do not share strong sequence conservation. The PP domain is not included in this sub-family. Most TPP-dependent enzymes have the PYR and PP domains on the same subunit although these domains can be alternatively arranged in the primary structure. TPP-dependent enzymes are multisubunit proteins, the smallest catalytic unit being a dimer-of-active sites, for many the active sites lie between PP and PYR domains on different subunits. POX decarboxylates pyruvate, producing hydrogen peroxide and the energy-storage metabolite acetylphosphate. This subfamily includes pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC catalyzes the conversion of pyruvate to acetaldehyde and CO2 in alcoholic fermentation. IPDC plays a role in the indole-3-pyruvic acid (IPA) pathway in plants and various plant-associated bacteria, it catalyzes the decarboxylation of IPA to IAA. This subfamily also includes the large catalytic subunit of acetohydroxyacid synthase (AHAS). AHAS catalyzes the condensation of two molecules of pyruvate to give the acetohydroxyacid, 2-acetolactate, a precursor of the branched chain amino acids, valine and leucine. AHAS also catalyzes the condensation of pyruvate and 2-ketobutyrate to form 2-aceto-2-hydroxybutyrate in isoleucine biosynthesis. Methanococcus jannaschii sulfopyruvate decarboxylase (MjComDE) and phosphonopyruvate decarboxylase (PpyrDc) also belong to this subfamily. PpyrDc is a homotrimeric enzyme having the PP and PYR domains tandemly arranged on the same subunit. It functions in the biosynthesis of C-P compounds such as bialaphos tripeptide in Streptomyces hygroscopicus. MjComDE is a dodecamer having the PYR and PP domains on different subunits, it has six alpha (PYR/ComD) subunits and six beta (PP/ComE) subunits. MjComDE catalyzes the decarboxylation of sulfopyruvic acid to sulfoacetaldehyde in the coenzyme M pathway.
Pssm-ID: 132918 [Multi-domain] Cd Length: 155 Bit Score: 140.36 E-value: 3.58e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 7 QHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYN 86
Cdd:cd07035 1 DALVEALKAEGVDHVFGVPGGAILPLLDALARSGIRYILVRHEQGAVGMADGYARATGKPGVVLVTSGPGLTNAVTGLAN 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6320816 87 SMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYIDVPA 160
Cdd:cd07035 81 AYLDSIPLLVITGQRPTAGEGRGAFQEIDQVALFRPITKWAYRVTsPEEIPEALRRAFRIALSGRPGPVALDLPK 155
|
|
| PRK06725 |
PRK06725 |
acetolactate synthase large subunit; |
4-473 |
1.27e-38 |
|
acetolactate synthase large subunit;
Pssm-ID: 180672 [Multi-domain] Cd Length: 570 Bit Score: 149.35 E-value: 1.27e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 4 TATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAG 83
Cdd:PRK06725 16 TGAGHVIQCLKKLGVTTVFGYPGGAILPVYDALYESGLKHILTRHEQAAIHAAEGYARASGKVGVVFATSGPGATNLVTG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 84 IYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLTPDN-IDMITQKALNYCIQGTAGVSYIDVPADF 162
Cdd:PRK06725 96 LADAYMDSIPLVVITGQVATPLIGKDGFQEADVVGITVPVTKHNYQVRDVNqLSRIVQEAFYIAESGRPGPVLIDIPKDV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 163 IEYEKPLEGNDRTgnELP-MILTPNicgPDPSKIKKVVQLIlqHKNKNILIVIGKGAVKN--SHEIRRLVNTFNLPFLPT 239
Cdd:PRK06725 176 QNEKVTSFYNEVV--EIPgYKPEPR---PDSMKLREVAKAI--SKAKRPLLYIGGGVIHSggSEELIEFARENRIPVVST 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 240 PMAKGIVPDSSPLNV-------SSARSQALKIADIVLVLGARLNWILHfGTSPKWNSESIFIQFDSNPETLGDNnvsPGA 312
Cdd:PRK06725 249 LMGLGAYPPGDPLFLgmlgmhgTYAANMAVTECDLLLALGVRFDDRVT-GKLELFSPHSKKVHIDIDPSEFHKN---VAV 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 313 DLSIWGDIGLSVTALVEE-LTRQDSCWkysgvkqeirekiqLNQTRLLRKEktrgAQLNYNQVYGTLRP-----LIDDY- 385
Cdd:PRK06725 325 EYPVVGDVKKALHMLLHMsIHTQTDEW--------------LQKVKTWKEE----YPLSYKQKESELKPqhvinLVSELt 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 386 --RTILVTEGANTMDIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQ 463
Cdd:PRK06725 387 ngEAIVTTEVGQHQMWAAHFYKAKNPRTFLTSGGLGTMGFGFPAAIGAQLAKEEELVICIAGDASFQMNIQELQTIAENN 466
|
490
....*....|
gi 6320816 464 LALVIVVMNN 473
Cdd:PRK06725 467 IPVKVFIINN 476
|
|
| PRK06276 |
PRK06276 |
acetolactate synthase large subunit; |
13-546 |
7.41e-38 |
|
acetolactate synthase large subunit;
Pssm-ID: 235766 [Multi-domain] Cd Length: 586 Bit Score: 147.21 E-value: 7.41e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 13 LQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSMSNRW 92
Cdd:PRK06276 11 LEAEGVKIIFGYPGGALLPFYDALYDSDLIHILTRHEQAAAHAADGYARASGKVGVCVATSGPGATNLVTGIATAYADSS 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 93 PLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYIDVPADFIEYEKPLEG 171
Cdd:PRK06276 91 PVIALTGQVPTKLIGNDAFQEIDALGIFMPITKHNFQIKkPEEIPEIFRAAFEIAKTGRPGPVHIDLPKDVQEGELDLEK 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 172 NDRTGN-ELPMiLTPNICGpDPSKIKKVVQLILQHKNKNILI---VIGKGAvknSHEIRRLVNTFNLPFLPTPMAKGIVP 247
Cdd:PRK06276 171 YPIPAKiDLPG-YKPTTFG-HPLQIKKAAELIAEAERPVILAgggVIISGA---SEELIELSELVKIPVCTTLMGKGAFP 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 248 DSSPLNV-------SSARSQALKIADIVLVLGARLN-----WILHFGTSPKwnsesiFIQFDSNPETLGDNnvsPGADLS 315
Cdd:PRK06276 246 EDHPLALgmvgmhgTKAANYSVTESDVLIAIGCRFSdrttgDISSFAPNAK------IIHIDIDPAEIGKN---VRVDVP 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 316 IWGDIGLSVTALVEELTRqdscwKYSGVKQEIREKIQLNQT----RLLRKEKTRGAQLNYNQVYGTLRPLIDDYRTILVT 391
Cdd:PRK06276 317 IVGDAKNVLRDLLAELMK-----KEIKNKSEWLERVKKLKKesipRMDFDDKPIKPQRVIKELMEVLREIDPSKNTIITT 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 392 E-GANTMDIARIsFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVIVV 470
Cdd:PRK06276 392 DvGQNQMWMAHF-FKTSAPRSFISSGGLGTMGFGFPAAIGAKVAKPDANVIAITGDGGFLMNSQELATIAEYDIPVVICI 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 471 MNN---------SGIYHGEKDIEGDLPPTAlskncryDLV--GKGLGANDFFVNTISELSRCFQQAVQlsrtKRETSVIN 539
Cdd:PRK06276 471 FDNrtlgmvyqwQNLYYGKRQSEVHLGETP-------DFVklAESYGVKADRVEKPDEIKEALKEAIK----SGEPYLLD 539
|
....*..
gi 6320816 540 VIIEPGE 546
Cdd:PRK06276 540 IIIDPAE 546
|
|
| TPP_enzyme_N |
pfam02776 |
Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; |
5-166 |
2.22e-37 |
|
Thiamine pyrophosphate enzyme, N-terminal TPP binding domain;
Pssm-ID: 460690 [Multi-domain] Cd Length: 169 Bit Score: 135.83 E-value: 2.22e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 5 ATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVAN-GIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAG 83
Cdd:pfam02776 1 GAEALADVLKALGVDTVFGVPGGHILPLLDALAKSpGIRYVLTRHEQGAAFAADGYARATGKPGVVLVTSGPGATNALTG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 84 IYNSMSNRWPLLVIAGSSSQSDIHKGGFQ-ELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYIDVPAD 161
Cdd:pfam02776 81 LANAYVDSVPLLVISGQRPRSLVGRGALQqELDQLALFRPVTKWAVRVTsADEIPEVLRRAFRAALSGRPGPVYLEIPLD 160
|
....*
gi 6320816 162 FIEYE 166
Cdd:pfam02776 161 VLLEE 165
|
|
| PRK07524 |
PRK07524 |
5-guanidino-2-oxopentanoate decarboxylase; |
2-530 |
6.01e-36 |
|
5-guanidino-2-oxopentanoate decarboxylase;
Pssm-ID: 236041 [Multi-domain] Cd Length: 535 Bit Score: 141.27 E-value: 6.01e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 2 TTTATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQaaSYAASAYGY--ISDKPGVLLIVGGPGLIH 79
Cdd:PRK07524 1 MTTCGEALVRLLEAYGVETVFGIPGVHTVELYRGLAGSGIRHVTPRHEQ--GAGFMADGYarVSGKPGVCFIITGPGMTN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 80 ALAGIYNSMSNRWPLLVIAGSSSQSDIHKG-GF-QEL-DQVSLLSPFLKFTGKL-TPDNIDMITQKALNYCIQGTAGVSY 155
Cdd:PRK07524 79 IATAMGQAYADSIPMLVISSVNRRASLGKGrGKlHELpDQRAMVAGVAAFSHTLmSAEDLPEVLARAFAVFDSARPRPVH 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 156 IDVPADFIEyekplEGNDRTGNELPMILTPNicGPDPSKIKKVVQLILQHKNKniLIVIGKGAVKNSHEIRRLVNTFNLP 235
Cdd:PRK07524 159 IEIPLDVLA-----APADHLLPAPPTRPARP--GPAPAALAQAAERLAAARRP--LILAGGGALAAAAALRALAERLDAP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 236 FLPTPMAKGIVPDSSPLNVSSARS-----QALKIADIVLVLGARL---NWILHF-GTSPkwnSESIFIQFDSNPETLGDN 306
Cdd:PRK07524 230 VALTINAKGLLPAGHPLLLGASQSlpavrALIAEADVVLAVGTELgetDYDVYFdGGFP---LPGELIRIDIDPDQLARN 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 307 nvsPGADLSIWGDIGLSVTALVEEL-----TRQDSCWKYSGVKQEIREKIqlnqtrllrkektRGAQLNYNQVYGTLRPL 381
Cdd:PRK07524 307 ---YPPALALVGDARAALEALLARLpgqaaAADWGAARVAALRQALRAEW-------------DPLTAAQVALLDTILAA 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 382 IDDyrTILVTEGANTMDIARISFPTDAPRRRLDAGTN-ATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAV 460
Cdd:PRK07524 371 LPD--AIFVGDSTQPVYAGNLYFDADAPRRWFNASTGyGTLGYGLPAAIGAALGAPERPVVCLVGDGGLQFTLPELASAV 448
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6320816 461 RCQLALVIVVMNNSGIYHGEKDIEG-DLPPTALS-KNCRYDLVGKGLGANDFFVNTISELSRCFQQAVQLSR 530
Cdd:PRK07524 449 EADLPLIVLLWNNDGYGEIRRYMVArDIEPVGVDpYTPDFIALARAFGCAAERVADLEQLQAALRAAFARPG 520
|
|
| TPP_enzyme_M |
pfam00205 |
Thiamine pyrophosphate enzyme, central domain; The central domain of TPP enzymes contains a ... |
195-327 |
1.40e-35 |
|
Thiamine pyrophosphate enzyme, central domain; The central domain of TPP enzymes contains a 2-fold Rossman fold.
Pssm-ID: 425523 [Multi-domain] Cd Length: 137 Bit Score: 129.99 E-value: 1.40e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 195 IKKVVQLILQHKNknILIVIGKGAV--KNSHEIRRLVNTFNLPFLPTPMAKGIVPDSSPLNV-------SSARSQALKIA 265
Cdd:pfam00205 1 IEKAAELLKKAKR--PVILAGGGVRrsGASEELRELAEKLGIPVVTTLMGKGAFPEDHPLYLgmlgmhgTPAANEALEEA 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6320816 266 DIVLVLGARLNWILHFGTSPKWNSESIFIQFDSNPETLGDNNvspGADLSIWGDIGLSVTAL 327
Cdd:pfam00205 79 DLVLAVGARFDDIRTTGKLPEFAPDAKIIHIDIDPAEIGKNY---PVDVPIVGDAKETLEAL 137
|
|
| PRK08527 |
PRK08527 |
acetolactate synthase large subunit; |
1-543 |
1.37e-34 |
|
acetolactate synthase large subunit;
Pssm-ID: 181458 [Multi-domain] Cd Length: 563 Bit Score: 137.54 E-value: 1.37e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 1 MTTTATQHFAQLLQKYGIDTVFGIVGIPIVQLAD-TMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIH 79
Cdd:PRK08527 1 KKLSGSQMVCEALKEEGVKVVFGYPGGAILNIYDeIYKQNYFKHILTRHEQAAVHAADGYARASGKVGVAIVTSGPGFTN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 80 ALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLK--FTGKlTPDNIDMITQKALNYCIQGTAGVSYID 157
Cdd:PRK08527 81 AVTGLATAYMDSIPLVLISGQVPNSLIGTDAFQEIDAVGISRPCVKhnYLVK-SIEELPRILKEAFYIARSGRPGPVHID 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 158 VPADFI----EYEKPLEGNDRTgnelpmiLTPNICGpDPSKIKKVVQLIlqHKNKNILIVIGKGAVKN--SHEIRRLVNT 231
Cdd:PRK08527 160 IPKDVTatlgEFEYPKEISLKT-------YKPTYKG-NSRQIKKAAEAI--KEAKKPLFYLGGGAILSnaSEEIRELVKK 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 232 FNLPFLPTPMAKGIVPDSSPLNV-------SSARSQALKIADIVLVLGARlnwilhF-----GTSPKWNSESIFIQFDSN 299
Cdd:PRK08527 230 TGIPAVETLMARGVLRSDDPLLLgmlgmhgSYAANMAMSECDLLISLGAR------FddrvtGKLSEFAKHAKIIHVDID 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 300 PETLGdnNVSPgADLSIWGDIGLSVTALVEELtrqdscwkysgvKQEIREKIQLNQTRLLRKEKTRgaQLNYNQVYGTLR 379
Cdd:PRK08527 304 PSSIS--KIVN-ADYPIVGDLKNVLKEMLEEL------------KEENPTTYKEWREILKRYNELH--PLSYEDSDEVLK 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 380 P---------LIDDYRTILVTEGANTMDIARIsFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFG 450
Cdd:PRK08527 367 PqwviervgeLLGDDAIISTDVGQHQMWVAQF-YPFNYPRQLATSGGLGTMGYGLPAALGAKLAVPDKVVINFTGDGSIL 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 451 FSAMEIETAVRCQLALVIVVMNNS---------GIYHGEKDIEGDLpptalskNCRYDLV--GKGLGANDFFVNTISELS 519
Cdd:PRK08527 446 MNIQELMTAVEYKIPVINIILNNNflgmvrqwqTFFYEERYSETDL-------STQPDFVklAESFGGIGFRVTTKEEFD 518
|
570 580
....*....|....*....|....
gi 6320816 520 RCFQQAVQlsrtKRETSVINVIIE 543
Cdd:PRK08527 519 KALKEALE----SDKVALIDVKID 538
|
|
| PRK06112 |
PRK06112 |
acetolactate synthase catalytic subunit; Validated |
3-484 |
2.42e-33 |
|
acetolactate synthase catalytic subunit; Validated
Pssm-ID: 235700 [Multi-domain] Cd Length: 578 Bit Score: 134.12 E-value: 2.42e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 3 TTATQHFAQLLQKYGIDTVFGiVGIP-IVQLADTmvANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHAL 81
Cdd:PRK06112 14 GTVAHAIARALKRHGVEQIFG-QSLPsALFLAAE--AIGIRQIAYRTENAGGAMADGYARVSGKVAVVTAQNGPAATLLV 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 82 AGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYIDVPA 160
Cdd:PRK06112 91 APLAEALKASVPIVALVQDVNRDQTDRNAFQELDHIALFQSCTKWVRRVTvAERIDDYVDQAFTAATSGRPGPVVLLLPA 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 161 DFIEYEKPLEGNDRTGN--ELPMILTPnicgPDPSKIKKVVQLILQHKNKnilIVIGKGAVKNS---HEIRRLVNTFNLP 235
Cdd:PRK06112 171 DLLTAAAAAPAAPRSNSlgHFPLDRTV----PAPQRLAEAASLLAQAQRP---VVVAGGGVHISgasAALAALQSLAGLP 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 236 FLPTPMAKGIVPDSSPLNV----------SSARSQA--LKIADIVLVLGARLNwilHFGTSpKWN---SESIFIQFDSNP 300
Cdd:PRK06112 244 VATTNMGKGAVDETHPLSLgvvgslmgprSPGRHLRdlVREADVVLLVGTRTN---QNGTD-SWSlypEQAQYIHIDVDG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 301 ETLGDNNVSpgadLSIWGDIGLSVTALVEELTRQD---SCWKYSGVKQEIREKIQLNQTRLLRKEKTRGAQLNYNQVYGT 377
Cdd:PRK06112 320 EEVGRNYEA----LRLVGDARLTLAALTDALRGRDlaaRAGRRAALEPAIAAGREAHREDSAPVALSDASPIRPERIMAE 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 378 LRPLIDDYRTILVTEGANTMDIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIE 457
Cdd:PRK06112 396 LQAVLTGDTIVVADASYSSIWVANFLTARRAGMRFLTPRGLAGLGWGVPMAIGAKVARPGAPVICLVGDGGFAHVWAELE 475
|
490 500
....*....|....*....|....*..
gi 6320816 458 TAVRCQLALVIVVMNNsGIYHGEKDIE 484
Cdd:PRK06112 476 TARRMGVPVTIVVLNN-GILGFQKHAE 501
|
|
| PRK06457 |
PRK06457 |
pyruvate dehydrogenase; Provisional |
11-547 |
4.74e-31 |
|
pyruvate dehydrogenase; Provisional
Pssm-ID: 180570 [Multi-domain] Cd Length: 549 Bit Score: 127.25 E-value: 4.74e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 11 QLLQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSMSN 90
Cdd:PRK06457 10 RVLEDNGIQRIYGIPGDSIDPLVDAIRKSKVKYVQVRHEEGAALAASVEAKITGKPSACMGTSGPGSIHLLNGLYDAKMD 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 91 RWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQgTAGVSYIDVPADFIEyekpl 169
Cdd:PRK06457 90 HAPVIALTGQVESDMIGHDYFQEVNLTKLFDDVAVFNQILInPENAEYIIRRAIREAIS-KRGVAHINLPVDILR----- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 170 EGNDRTGNELPMILTPNIcGPDPSKIKKVVQlilqhKNKNILIVIGKGAVKNSHEIRRLVNTFNLPFLPTPMAKGIVPDS 249
Cdd:PRK06457 164 KSSEYKGSKNTEVGKVKY-SIDFSRAKELIK-----ESEKPVLLIGGGTRGLGKEINRFAEKIGAPIIYTLNGKGILPDL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 250 SP-------LNVSSARSQALKIADIVLVLGARlnwilhFGTSPKWNSESIFIQFDSNPETLGDNnvsPGADLSIWGDIGL 322
Cdd:PRK06457 238 DPkvmggigLLGTKPSIEAMDKADLLIMLGTS------FPYVNFLNKSAKVIQVDIDNSNIGKR---LDVDLSYPIPVAE 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 323 SVTALVEELTRQdscwKYSGVKQEIREKIQlnqtRLLRKEKTRGAQLNYNQVYGTLRPLIDDYRTILVTEGANTMDIARi 402
Cdd:PRK06457 309 FLNIDIEEKSDK----FYEELKGKKEDWLD----SISKQENSLDKPMKPQRVAYIVSQKCKKDAVIVTDTGNVTMWTAR- 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 403 SFPTDAPRRRLDAGTNATMGIGL-GYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVIVVMNNS--GIYHG 479
Cdd:PRK06457 380 HFRASGEQTFIFSAWLGSMGIGVpGSVGASFAVENKRQVISFVGDGGFTMTMMELITAKKYDLPVKIIIYNNSklGMIKF 459
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6320816 480 EKDIEG------DLPPTALSKncrydlVGKGLGANDFFVNTISELSrcfqQAVQLSRTKRETSVINVIIEPGEQ 547
Cdd:PRK06457 460 EQEVMGypewgvDLYNPDFTK------IAESIGFKGFRLEEPKEAE----EIIEEFLNTKGPAVLDAIVDPNER 523
|
|
| PRK06882 |
PRK06882 |
acetolactate synthase 3 large subunit; |
11-473 |
1.12e-30 |
|
acetolactate synthase 3 large subunit;
Pssm-ID: 168717 [Multi-domain] Cd Length: 574 Bit Score: 126.18 E-value: 1.12e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 11 QLLQKYGIDTVFGIVGIPIVQLADTM-VANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSMS 89
Cdd:PRK06882 12 QSLRDEGVEYVFGYPGGSVLDIYDAIhTLGGIEHVLVRHEQAAVHMADGYARSTGKVGCVLVTSGPGATNAITGIATAYT 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 90 NRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYIDVPADFIE---- 164
Cdd:PRK06882 92 DSVPLVILSGQVPSNLIGTDAFQECDMLGISRPVVKHSFIVKnAEDIPSTIKKAFYIASTGRPGPVVIDIPKDMVNpank 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 165 --YEKPLEGNDRTGNelpmiltPNICGpDPSKIKKVVQLILQHKnKNILIVIGKGAVKN-SHEIRRLVNTFNLPFLPTPM 241
Cdd:PRK06882 172 ftYEYPEEVSLRSYN-------PTVQG-HKGQIKKALKALLVAK-KPVLFVGGGVITAEcSEQLTQFAQKLNLPVTSSLM 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 242 AKGIVPDSSP-------LNVSSARSQALKIADIVLVLGARLNwILHFGTSPKWNSESIFIQFDSNPETLgDNNVSpgADL 314
Cdd:PRK06882 243 GLGAYPSTDKqflgmlgMHGTYEANNAMHESDLILGIGVRFD-DRTTNNLAKYCPNAKVIHIDIDPTSI-SKNVP--AYI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 315 SIWGDIGLSVT---ALVEELTRQDSCWKYSGVKQEIREkiqLNQTRLLRKEKTRGAqLNYNQVYGTLRPLIDDYRTILVT 391
Cdd:PRK06882 319 PIVGSAKNVLEeflSLLEEENLAKSQTDLTAWWQQINE---WKAKKCLEFDRTSDV-IKPQQVVEAIYRLTNGDAYVASD 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 392 EGANTMdIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVIVVM 471
Cdd:PRK06882 395 VGQHQM-FAALHYPFDKPRRWINSGGAGTMGFGLPAAIGVKFAHPEATVVCVTGDGSIQMNIQELSTAKQYDIPVVIVSL 473
|
..
gi 6320816 472 NN 473
Cdd:PRK06882 474 NN 475
|
|
| PRK07282 |
PRK07282 |
acetolactate synthase large subunit; |
3-473 |
2.86e-30 |
|
acetolactate synthase large subunit;
Pssm-ID: 180919 [Multi-domain] Cd Length: 566 Bit Score: 124.93 E-value: 2.86e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 3 TTATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVAN-GIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHAL 81
Cdd:PRK07282 10 KSGSDLVLETLRDLGVDTIFGYPGGAVLPLYDAIYNFeGIRHILARHEQGALHEAEGYAKSTGKLGVAVVTSGPGATNAI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 82 AGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKL--TPDnIDMITQKALNYCIQGTAGVSYIDVP 159
Cdd:PRK07282 90 TGIADAMSDSVPLLVFTGQVARAGIGKDAFQEADIVGITMPITKYNYQIreTAD-IPRIITEAVHIATTGRPGPVVIDLP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 160 ADFIEYEKPlEGNDRTGNeLPMiLTPNIcGPDPSKIKKVVQLILQHKNKNILIVIGKGAVKNSHEIRRLVNTFNLPFLPT 239
Cdd:PRK07282 169 KDVSALETD-FIYDPEVN-LPS-YQPTL-EPNDMQIKKILKQLSKAKKPVILAGGGINYAEAATELNAFAERYQIPVVTT 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 240 PMAKGIVPDSSPLNV-------SSARSQALKIADIVLVLGARLNWILhFGTSPKWNSESIFIQFDSNPETLGdNNVSpgA 312
Cdd:PRK07282 245 LLGQGTIATSHPLFLgmggmhgSYAANIAMTEADFMINIGSRFDDRL-TGNPKTFAKNAKVAHIDIDPAEIG-KIIK--T 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 313 DLSIWGDIGLSVTALVEELTrqdscwkysgVKQEIREKIqlnQTRLLRKEKTRgaqlNYNQVYGTLRP-----LIDDYR- 386
Cdd:PRK07282 321 DIPVVGDAKKALQMLLAEPT----------VHNNTEKWI---EKVTKDKNRVR----SYDKKERVVQPqavieRIGELTn 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 387 --TILVTE-GANTMDIARIsFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQ 463
Cdd:PRK07282 384 gdAIVVTDvGQHQMWAAQY-YPYQNERQLVTSGGLGTMGFGIPAAIGAKIANPDKEVILFVGDGGFQMTNQELAILNIYK 462
|
490
....*....|
gi 6320816 464 LALVIVVMNN 473
Cdd:PRK07282 463 VPIKVVMLNN 472
|
|
| PRK06466 |
PRK06466 |
acetolactate synthase 3 large subunit; |
11-473 |
2.05e-29 |
|
acetolactate synthase 3 large subunit;
Pssm-ID: 180578 [Multi-domain] Cd Length: 574 Bit Score: 122.55 E-value: 2.05e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 11 QLLQKYGIDTVFGIVGIPIVQLADTMV-ANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSMS 89
Cdd:PRK06466 12 RALRDEGVEYIYGYPGGAVLHIYDALFkQDKVEHILVRHEQAATHMADGYARATGKTGVVLVTSGPGATNAITGIATAYM 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 90 NRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYIDVPADF------ 162
Cdd:PRK06466 92 DSIPMVVLSGQVPSTLIGEDAFQETDMVGISRPIVKHSFMVKhASEIPEIIKKAFYIAQSGRPGPVVVDIPKDMtnpaek 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 163 IEYEKPLEGNDRTgnelpmiLTPNICGpDPSKIKKVVQLILQHKNKniLIVIGKGAV--KNSHEIRRLVNTFNLPFLPTP 240
Cdd:PRK06466 172 FEYEYPKKVKLRS-------YSPAVRG-HSGQIRKAVEMLLAAKRP--VIYSGGGVVlgNASALLTELAHLLNLPVTNTL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 241 MAKGIVPDSSPLNV-------SSARSQALKIADIVLVLGARLNWILHFGTSpKWNSESIFIQFDSNPETLGDNNVspgAD 313
Cdd:PRK06466 242 MGLGGFPGTDRQFLgmlgmhgTYEANMAMHHADVILAVGARFDDRVTNGPA-KFCPNAKIIHIDIDPASISKTIK---AD 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 314 LSIWGDIGLSVTALVEELTRQDSC---------WKysgvkqeirekiQLNQTR----LLRKEKTRGAQLNYNQVYGTLRP 380
Cdd:PRK06466 318 IPIVGPVESVLTEMLAILKEIGEKpdkealaawWK------------QIDEWRgrhgLFPYDKGDGGIIKPQQVVETLYE 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 381 LIDDYRTILVTEGANTMdIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAV 460
Cdd:PRK06466 386 VTNGDAYVTSDVGQHQM-FAAQYYKFNKPNRWINSGGLGTMGFGLPAAMGVKLAFPDQDVACVTGEGSIQMNIQELSTCL 464
|
490
....*....|...
gi 6320816 461 RCQLALVIVVMNN 473
Cdd:PRK06466 465 QYGLPVKIINLNN 477
|
|
| PRK08979 |
PRK08979 |
acetolactate synthase 3 large subunit; |
17-473 |
2.53e-29 |
|
acetolactate synthase 3 large subunit;
Pssm-ID: 181602 [Multi-domain] Cd Length: 572 Bit Score: 122.24 E-value: 2.53e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 17 GIDTVFGIVGIPIVQLADTM-VANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSMSNRWPLL 95
Cdd:PRK08979 18 GVKHIFGYPGGSVLDIYDALhEKSGIEHILVRHEQAAVHMADGYARATGKVGVVLVTSGPGATNTITGIATAYMDSIPMV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 96 VIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYIDVPADFI------EYEKP 168
Cdd:PRK08979 98 VLSGQVPSNLIGNDAFQECDMIGISRPVVKHSFLVKdAEDIPEIIKKAFYIASTGRPGPVVIDLPKDCLnpailhPYEYP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 169 LEGNDRTGNelpmiltPNICGpDPSKIKKVVQLILQHKnKNILIVIGKGAVKNSHE-IRRLVNTFNLPFLPTPMAKGIVP 247
Cdd:PRK08979 178 ESIKMRSYN-------PTTSG-HKGQIKRGLQALLAAK-KPVLYVGGGAIISGADKqILQLAEKLNLPVVSTLMGLGAFP 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 248 DSSPLNVSS-------ARSQALKIADIVLVLGARLNwilHFGTS--PKWNSESIFIQFDSNPETLGDNnvsPGADLSIWG 318
Cdd:PRK08979 249 GTHKNSLGMlgmhgryEANMAMHNADLIFGIGVRFD---DRTTNnlEKYCPNATILHIDIDPSSISKT---VRVDIPIVG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 319 DIGLSVTALVEELTRQDSCWKYSGVKQEIREKIQLNQTRLLRKEKTRGaQLNYNQVYGTLRPLIDDYRTILVTEGANTMd 398
Cdd:PRK08979 323 SADKVLDSMLALLDESGETNDEAAIASWWNEIEVWRSRNCLAYDKSSE-RIKPQQVIETLYKLTNGDAYVASDVGQHQM- 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6320816 399 IARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVIVVMNN 473
Cdd:PRK08979 401 FAALYYPFDKPRRWINSGGLGTMGFGLPAAMGVKFAMPDETVVCVTGDGSIQMNIQELSTALQYDIPVKIINLNN 475
|
|
| PRK06154 |
PRK06154 |
thiamine pyrophosphate-requiring protein; |
2-554 |
5.39e-29 |
|
thiamine pyrophosphate-requiring protein;
Pssm-ID: 235718 [Multi-domain] Cd Length: 565 Bit Score: 121.07 E-value: 5.39e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 2 TTTATQHFAQLLQKYGIDTVFGIvgiPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYIS--DKPGVLLIVGGPGLIH 79
Cdd:PRK06154 19 TMKVAEAVAEILKEEGVELLFGF---PVNELFDAAAAAGIRPVIARTERVAVHMADGYARATsgERVGVFAVQYGPGAEN 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 80 ALAGIYNSMSNRWPLLVIAGSSSQSDIH-KGGFQELDQvslLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYID 157
Cdd:PRK06154 96 AFGGVAQAYGDSVPVLFLPTGYPRGSTDvAPNFESLRN---YRHITKWCEQVTlPDEVPELMRRAFTRLRNGRPGPVVLE 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 158 VPADFIEYEKPlegndrtgnELPMILTPN---ICGPDPSKIKKVVQLILQHKNKNILIVIGKGAVKNSHEIRRLVNTFNL 234
Cdd:PRK06154 173 LPVDVLAEELD---------ELPLDHRPSrrsRPGADPVEVVEAAALLLAAERPVIYAGQGVLYAQATPELKELAELLEI 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 235 PFLPTPMAKGIVPDSSPLNVSSAR-------SQALKIADIVLVLGARLNWILHFGTSPKwnsESIFIQFDSNPETLGDNN 307
Cdd:PRK06154 244 PVMTTLNGKSAFPEDHPLALGSGGrarpatvAHFLREADVLFGIGCSLTRSYYGLPMPE---GKTIIHSTLDDADLNKDY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 308 VSpgaDLSIWGDIGLSVTALVEELTRQ--DSCWKYSGVKQEIREKIQLNQTRLLRKEKTRGAQLNYNQVYGTLRPLIDDY 385
Cdd:PRK06154 321 PI---DHGLVGDAALVLKQMIEELRRRvgPDRGRAQQVAAEIEAVRAAWLAKWMPKLTSDSTPINPYRVVWELQHAVDIK 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 386 RTILVTEGANTMDIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLA 465
Cdd:PRK06154 398 TVIITHDAGSPRDQLSPFYVASRPGSYLGWGKTTQLGYGLGLAMGAKLARPDALVINLWGDAAFGMTGMDFETAVRERIP 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 466 LVIVVMNNS--GIY----------HGEKDIEGDlpptalskncrYDLVGKGLGANDFFVNTISELSRCFQQAVQLSRTKR 533
Cdd:PRK06154 478 ILTILLNNFsmGGYdkvmpvsttkYRATDISGD-----------YAAIARALGGYGERVEDPEMLVPALLRALRKVKEGT 546
|
570 580
....*....|....*....|.
gi 6320816 534 eTSVINVIIepGEQKQIAFAW 554
Cdd:PRK06154 547 -PALLEVIT--SEETALSRPW 564
|
|
| PRK06048 |
PRK06048 |
acetolactate synthase large subunit; |
4-543 |
5.80e-29 |
|
acetolactate synthase large subunit;
Pssm-ID: 180368 [Multi-domain] Cd Length: 561 Bit Score: 121.04 E-value: 5.80e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 4 TATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAG 83
Cdd:PRK06048 9 TGARAIIKCLEKEGVEVIFGYPGGAIIPVYDELYDSDLRHILVRHEQAAAHAADGYARATGKVGVCVATSGPGATNLVTG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 84 IYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYIDVPADF 162
Cdd:PRK06048 89 IATAYMDSVPIVALTGQVPRSMIGNDAFQEADITGITMPITKHNYLVQdAKDLPRIIKEAFHIASTGRPGPVLIDLPKDV 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 163 IEYEKPLEGNDRTgnELPMiLTPNICGpDPSKIKKVVQLILqhKNKNILIVIGKGAVKN--SHEIRRLVNTFNLPFLPTP 240
Cdd:PRK06048 169 TTAEIDFDYPDKV--ELRG-YKPTYKG-NPQQIKRAAELIM--KAERPIIYAGGGVISSnaSEELVELAETIPAPVTTTL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 241 MAKGIVPDSSPLNV-------SSARSQALKIADIVLVLGARLNWILHfGTSPKWNSESIFIQFDSNPETLGDN-NVspga 312
Cdd:PRK06048 243 MGIGAIPTEHPLSLgmlgmhgTKYANYAIQESDLIIAVGARFDDRVT-GKLASFAPNAKIIHIDIDPAEISKNvKV---- 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 313 DLSIWGDIGLSVTALVEELTRQDScwkysgvkQEIREKIqlNQTRllrkektRGAQLNYNQVYGTLRP---------LID 383
Cdd:PRK06048 318 DVPIVGDAKQVLKSLIKYVQYCDR--------KEWLDKI--NQWK-------KEYPLKYKEREDVIKPqyvieqiyeLCP 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 384 DyrTILVTE-GANTMDIARIsFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRC 462
Cdd:PRK06048 381 D--AIIVTEvGQHQMWAAQY-FKYKYPRTFITSGGLGTMGYGFPAAIGAKVGKPDKTVIDIAGDGSFQMNSQELATAVQN 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 463 QLALVIVVMNNSgiYHG------EKDIEGDLPPTALSKNCRYDLVGKGLGANDFFVNTISELSRCFQQAVQLSRtkreTS 536
Cdd:PRK06048 458 DIPVIVAILNNG--YLGmvrqwqELFYDKRYSHTCIKGSVDFVKLAEAYGALGLRVEKPSEVRPAIEEAVASDR----PV 531
|
....*..
gi 6320816 537 VINVIIE 543
Cdd:PRK06048 532 VIDFIVE 538
|
|
| PRK08327 |
PRK08327 |
thiamine pyrophosphate-requiring protein; |
60-544 |
1.66e-28 |
|
thiamine pyrophosphate-requiring protein;
Pssm-ID: 236243 [Multi-domain] Cd Length: 569 Bit Score: 119.72 E-value: 1.66e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 60 GY--ISDKPGVLLIVGGPGLIHALAGIYNSMSNRWPLLVIAGSSSQSD----------IHKGgfQE-LDQVSLLSPFLKF 126
Cdd:PRK08327 68 GYalVTGKPQAVMVHVDVGTANALGGVHNAARSRIPVLVFAGRSPYTEegelgsrntrIHWT--QEmRDQGGLVREYVKW 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 127 TGKL-TPDNIDMITQKALNYCIQGTAGVSYIDVPADFIEYEKPLEGNDRTGNelpmiLTPNICGPDPSKIKKVVQLILQH 205
Cdd:PRK08327 146 DYEIrRGDQIGEVVARAIQIAMSEPKGPVYLTLPREVLAEEVPEVKADAGRQ-----MAPAPPAPDPEDIARAAEMLAAA 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 206 KNKniLIVIGKGAvkNSHE----IRRLVNTFNLP---FLPTPMAkgiVPDSSPLNVSSARSQALKIADIVLVLGARLNWI 278
Cdd:PRK08327 221 ERP--VIITWRAG--RTAEgfasLRRLAEELAIPvveYAGEVVN---YPSDHPLHLGPDPRADLAEADLVLVVDSDVPWI 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 279 lhfgtsPKWNSESI---FIQFDSNPeTLGDNNV-SPGADLSIWGDIGLSVTALVEELTRQDS-----CWKYSGVKQEIRE 349
Cdd:PRK08327 294 ------PKKIRPDAdarVIQIDVDP-LKSRIPLwGFPCDLCIQADTSTALDQLEERLKSLASaerrrARRRRAAVRELRI 366
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 350 KIQLNQTRLLRKEKTRG----AQLNYnqvygTLRPLIDDYRTIlVTEGANTMDIARisfpTDAPRRRLDAGTNATMGIGL 425
Cdd:PRK08327 367 RQEAAKRAEIERLKDRGpitpAYLSY-----CLGEVADEYDAI-VTEYPFVPRQAR----LNKPGSYFGDGSAGGLGWAL 436
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 426 GYALACKASHPELDVVLIQGDSAFGFSAmeiETAV-----RCQLALVIVVMNNSG----------IY-HGEKDIEGDLPP 489
Cdd:PRK08327 437 GAALGAKLATPDRLVIATVGDGSFIFGV---PEAAhwvaeRYGLPVLVVVFNNGGwlavkeavleVYpEGYAARKGTFPG 513
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 6320816 490 TALSKNCRYDLVGKGLGANDFFVNTISELSRCFQQAVQLSRTKRETSVINVIIEP 544
Cdd:PRK08327 514 TDFDPRPDFAKIAEAFGGYGERVEDPEELKGALRRALAAVRKGRRSAVLDVIVDR 568
|
|
| PRK07979 |
PRK07979 |
acetolactate synthase 3 large subunit; |
17-473 |
6.08e-28 |
|
acetolactate synthase 3 large subunit;
Pssm-ID: 181185 [Multi-domain] Cd Length: 574 Bit Score: 118.03 E-value: 6.08e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 17 GIDTVFGIVGIPIVQLADTM-VANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSMSNRWPLL 95
Cdd:PRK07979 18 GVKQVFGYPGGAVLDIYDALhTVGGIDHVLVRHEQAAVHMADGLARATGEVGVVLVTSGPGATNAITGIATAYMDSIPLV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 96 VIAGSSSQSDIHKGGFQELDQVSLLSPFLK--FTGKLTPDnIDMITQKALNYCIQGTAGVSYIDVPADFIE------YEK 167
Cdd:PRK07979 98 VLSGQVATSLIGYDAFQECDMVGISRPVVKhsFLVKQTED-IPQVLKKAFWLAASGRPGPVVVDLPKDILNpanklpYVW 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 168 PLEGNDRTGNelpmiltPNICGpDPSKIKKVVQLILQHKNKniLIVIGKGAVkNSH---EIRRLVNTFNLPFLPTPMAKG 244
Cdd:PRK07979 177 PESVSMRSYN-------PTTQG-HKGQIKRALQTLVAAKKP--VVYVGGGAI-NAAchqQLKELVEKLNLPVVSSLMGLG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 245 IVPDSSPLNV-------SSARSQALKIADIVLVLGARLNwILHFGTSPKWNSESIFIQFDSNPETLGDnnvSPGADLSIW 317
Cdd:PRK07979 246 AFPATHRQSLgmlgmhgTYEANMTMHNADVIFAVGVRFD-DRTTNNLAKYCPNATVLHIDIDPTSISK---TVTADIPIV 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 318 GDIGLSVTALVEELTRQDSCWKYSGVKqEIREKIQLNQTRLLRKEKTRGAQLNYNQVYGTLRPLIDDYRTILVTEGANTM 397
Cdd:PRK07979 322 GDARQVLEQMLELLSQESAHQPLDEIR-DWWQQIEQWRARQCLKYDTHSEKIKPQAVIETLWRLTKGDAYVTSDVGQHQM 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6320816 398 dIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVIVVMNN 473
Cdd:PRK07979 401 -FAALYYPFDKPRRWINSGGLGTMGFGLPAALGVKMALPEETVVCVTGDGSIQMNIQELSTALQYELPVLVLNLNN 475
|
|
| PRK08155 |
PRK08155 |
acetolactate synthase large subunit; |
1-483 |
7.91e-26 |
|
acetolactate synthase large subunit;
Pssm-ID: 181257 [Multi-domain] Cd Length: 564 Bit Score: 111.34 E-value: 7.91e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 1 MTTTATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANG-IKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIH 79
Cdd:PRK08155 11 KRFTGAELIVRLLERQGIRIVTGIPGGAILPLYDALSQSTqIRHILARHEQGAGFIAQGMARTTGKPAVCMACSGPGATN 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 80 ALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKL-TPDNIDMITQKALNYCIQGTAGVSYIDV 158
Cdd:PRK08155 91 LVTAIADARLDSIPLVCITGQVPASMIGTDAFQEVDTYGISIPITKHNYLVrDIEELPQVISDAFRIAQSGRPGPVWIDI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 159 PADFIEYEKPLEgndrtgnELPMILTPN-ICGPDPSKIKKVVQLILQHKNKniLIVIGKGAVKN--SHEIRRLVNTFNLP 235
Cdd:PRK08155 171 PKDVQTAVIELE-------ALPAPAEKDaAPAFDEESIRDAAAMINAAKRP--VLYLGGGVINSgaPARARELAEKAQLP 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 236 FLPTPMAKGIVPDSSPLNVS-----SARSQ--ALKIADIVLVLGARlnwilhF-----GTSPKWNSESIFIQFDSNPETL 303
Cdd:PRK08155 242 TTMTLMALGMLPKAHPLSLGmlgmhGARSTnyILQEADLLIVLGAR------FddraiGKTEQFCPNAKIIHVDIDRAEL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 304 GdnNVSPgADLSIWGDIGLSVTALVEELTRQDscwkysgvKQEIREKIQLNQTRLLRKEKTRGAQLNYnqvYGTLRPL-- 381
Cdd:PRK08155 316 G--KIKQ-PHVAIQADVDDVLAQLLPLVEAQP--------RAEWHQLVADLQREFPCPIPKADDPLSH---YGLINAVaa 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 382 -IDDYRTILVTEGANTMDIARiSFPTDAPRRRLDAGTNATMGIGL----GYALACkashPELDVVLIQGDSAFGFSAMEI 456
Cdd:PRK08155 382 cVDDNAIITTDVGQHQMWTAQ-AYPLNRPRQWLTSGGLGTMGFGLpaaiGAALAN----PERKVLCFSGDGSLMMNIQEM 456
|
490 500
....*....|....*....|....*....
gi 6320816 457 ETAVRCQLALVIVVMNNS--GIYHGEKDI 483
Cdd:PRK08155 457 ATAAENQLDVKIILMNNEalGLVHQQQSL 485
|
|
| ilvB |
CHL00099 |
acetohydroxyacid synthase large subunit |
6-473 |
1.83e-25 |
|
acetohydroxyacid synthase large subunit
Pssm-ID: 214363 [Multi-domain] Cd Length: 585 Bit Score: 110.56 E-value: 1.83e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 6 TQHFAQL--LQKYGIDTVFGIVGIPIVQLADTMVA----NGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIH 79
Cdd:CHL00099 11 TGAFALIdsLVRHGVKHIFGYPGGAILPIYDELYAwekkGLIKHILVRHEQGAAHAADGYARSTGKVGVCFATSGPGATN 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 80 ALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKL-TPDNIDMITQKALNYCIQGTAGVSYIDV 158
Cdd:CHL00099 91 LVTGIATAQMDSVPLLVITGQVGRAFIGTDAFQEVDIFGITLPIVKHSYVVrDARDISRIVAEAFYIAKHGRPGPVLIDI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 159 PADF----IEYEKPLEGNdrtgNELPMILTPNICGPDPSKIKKVVQLILQHKNKniLIVIGKGAV--KNSHEIRRLVNTF 232
Cdd:CHL00099 171 PKDVglekFDYYPPEPGN----TIIKILGCRPIYKPTIKRIEQAAKLILQSSQP--LLYVGGGAIisDAHQEITELAELY 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 233 NLPFLPTPMAKGIVPDSSPLNV-------SSARSQALKIADIVLVLGARlnwilhF-----GTSPKWNSESIFIQFDSNP 300
Cdd:CHL00099 245 KIPVTTTLMGKGIFDEDHPLCLgmlgmhgTAYANFAVSECDLLIALGAR------FddrvtGKLDEFACNAQVIHIDIDP 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 301 ETLGDNNVSpgaDLSIWGDIGLSVTALVEELTRQDSCWkYSGVKQEIREKIQL--NQTRLL--RKEKTRGAQLNYNQVyG 376
Cdd:CHL00099 319 AEIGKNRIP---QVAIVGDVKKVLQELLELLKNSPNLL-ESEQTQAWRERINRwrKEYPLLipKPSTSLSPQEVINEI-S 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 377 TLRPliDDYRTILVteGANTMDIARisFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEI 456
Cdd:CHL00099 394 QLAP--DAYFTTDV--GQHQMWAAQ--FLKCKPRKWLSSAGLGTMGYGLPAAIGAQIAHPNELVICISGDASFQMNLQEL 467
|
490
....*....|....*..
gi 6320816 457 ETAVRCQLALVIVVMNN 473
Cdd:CHL00099 468 GTIAQYNLPIKIIIINN 484
|
|
| PRK07418 |
PRK07418 |
acetolactate synthase large subunit; |
13-473 |
5.39e-25 |
|
acetolactate synthase large subunit;
Pssm-ID: 236014 [Multi-domain] Cd Length: 616 Bit Score: 109.37 E-value: 5.39e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 13 LQKYGIDTVFGIVGIPIVQLADTMV---ANG-IKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSM 88
Cdd:PRK07418 29 LKRHGVKHIFGYPGGAILPIYDELYkaeAEGwLKHILVRHEQGAAHAADGYARATGKVGVCFGTSGPGATNLVTGIATAQ 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 89 SNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKL-TPDNIDMITQKALNYCIQGTAGVSYIDVPAD----FI 163
Cdd:PRK07418 109 MDSVPMVVITGQVPRPAIGTDAFQETDIFGITLPIVKHSYVVrDPSDMARIVAEAFHIASSGRPGPVLIDIPKDvgqeEF 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 164 EYEkPLEgndrTGNELPMILTPNIcGPDPSKIKKVVQLILQHKNKniLIVIGKGAVK-NSH-EIRRLVNTFNLPFLPTPM 241
Cdd:PRK07418 189 DYV-PVE----PGSVKPPGYRPTV-KGNPRQINAALKLIEEAERP--LLYVGGGAISaGAHaELKELAERFQIPVTTTLM 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 242 AKGIVPDSSPLNVS------SARSQ-ALKIADIVLVLGARlnwilhF-----GTSPKWNSESIFIQFDSNPETLGDNNVs 309
Cdd:PRK07418 261 GKGAFDEHHPLSVGmlgmhgTAYANfAVTECDLLIAVGAR------FddrvtGKLDEFASRAKVIHIDIDPAEVGKNRR- 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 310 pgADLSIWGDIGLSVTALVEELTRQdscwKYSGVKQEIREKIQLNQTRLLRKEKTRGAQLNYNQVYGTLRPLIDD-YRTI 388
Cdd:PRK07418 334 --PDVPIVGDVRKVLVKLLERSLEP----TTPPRTQAWLERINRWKQDYPLVVPPYEGEIYPQEVLLAVRDLAPDaYYTT 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 389 LVteGANTMDIARisFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVI 468
Cdd:PRK07418 408 DV--GQHQMWAAQ--FLRNGPRRWISSAGLGTMGFGMPAAMGVKVALPDEEVICIAGDASFLMNIQELGTLAQYGINVKT 483
|
....*
gi 6320816 469 VVMNN 473
Cdd:PRK07418 484 VIINN 488
|
|
| PRK06456 |
PRK06456 |
acetolactate synthase large subunit; |
13-527 |
5.73e-25 |
|
acetolactate synthase large subunit;
Pssm-ID: 180569 [Multi-domain] Cd Length: 572 Bit Score: 108.77 E-value: 5.73e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 13 LQKYGIDTVFGIVGIPIVQLADTM---VANG-IKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSM 88
Cdd:PRK06456 12 LKREGVKVIFGIPGLSNMQIYDAFvedLANGeLRHVLMRHEQAAAHAADGYARASGVPGVCTATSGPGTTNLVTGLITAY 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 89 SNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKL-TPDNIDMITQKALNYCIQGTAGVSYIDVPADfIEYEK 167
Cdd:PRK06456 92 WDSSPVIAITGQVPRSVMGKMAFQEADAMGVFENVTKYVIGIkRIDEIPQWIKNAFYIATTGRPGPVVIDIPRD-IFYEK 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 168 ---------PLEGNDRtgnELPMILtpnicgpDPSKIKKVVQLILQHKNKniLIVIGKGAV--KNSHEIRRLVNTFNLPF 236
Cdd:PRK06456 171 meeikwpekPLVKGYR---DFPTRI-------DRLALKKAAEILINAERP--IILVGTGVVwsNATPEVLELAELLHIPI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 237 LPTPMAKGIVPDSSPLNVSS----ARSQALKIA---DIVLVLGARLnwilhfgtspkwnSESIFIQFDSNPET---LGDN 306
Cdd:PRK06456 239 VSTFPGKTAIPHDHPLYFGPmgyyGRAEASMAAlesDAMLVVGARF-------------SDRTFTSYDEMVETrkkFIMV 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 307 NVSPG-------ADLSIWGDIGL----SVTALVEELTRQD-SCWkysgvkqeirekiqlnqTRLLRKEKTRGAQLNYNQV 374
Cdd:PRK06456 306 NIDPTdgekaikVDVGIYGNAKIilreLIKAITELGQKRDrSAW-----------------LKRVKEYKEYYSQFYYTEE 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 375 YGTLRP--LIDDYRTIL-----VTEGANTMDI-ARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGD 446
Cdd:PRK06456 369 NGKLKPwkIMKTIRQALprdaiVTTGVGQHQMwAEVFWEVLEPRTFLTSSGMGTMGFGLPAAMGAKLARPDKVVVDLDGD 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 447 SAFGFSAMEIETAVRCQLALVIVVMNN---------SGIYHGEKDIEGDLPPTAlskncryDLV--GKGLGANDFFVNTI 515
Cdd:PRK06456 449 GSFLMTGTNLATAVDEHIPVISVIFDNrtlglvrqvQDLFFGKRIVGVDYGPSP-------DFVklAEAFGALGFNVTTY 521
|
570
....*....|..
gi 6320816 516 SELSRCFQQAVQ 527
Cdd:PRK06456 522 EDIEKSLKSAIK 533
|
|
| PRK06965 |
PRK06965 |
acetolactate synthase 3 catalytic subunit; Validated |
13-473 |
6.82e-24 |
|
acetolactate synthase 3 catalytic subunit; Validated
Pssm-ID: 180780 [Multi-domain] Cd Length: 587 Bit Score: 105.66 E-value: 6.82e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 13 LQKYGIDTVFGIVGIPIVQLADTMVA-NGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSMSNR 91
Cdd:PRK06965 31 LAAEGVEFIWGYPGGAVLYIYDELYKqDKIQHVLVRHEQAAVHAADGYARATGKVGVALVTSGPGVTNAVTGIATAYMDS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 92 WPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLK--FTGKlTPDNIDMITQKALNYCIQGTAGVSYIDVPADF----IEY 165
Cdd:PRK06965 111 IPMVVISGQVPTAAIGQDAFQECDTVGITRPIVKhnFLVK-DVRDLAETVKKAFYIARTGRPGPVVVDIPKDVsktpCEY 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 166 EKPLEGNDRTGNelpmiltPNICGpDPSKIKKVVQLILQHKNKniLIVIGKGAV--KNSHEIRRLVNTFNLPFLPTPMAK 243
Cdd:PRK06965 190 EYPKSVEMRSYN-------PVTKG-HSGQIRKAVSLLLSAKRP--YIYTGGGVIlaNASRELRQLADLLGYPVTNTLMGL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 244 GIVPDSSP-------LNVSSARSQALKIADIVLVLGARLNWIL-----HFGTSPKwnsesIFIQFDSNPETLGDNnvsPG 311
Cdd:PRK06965 260 GAYPASDKkflgmlgMHGTYEANMAMQHCDVLIAIGARFDDRVignpaHFASRPR-----KIIHIDIDPSSISKR---VK 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 312 ADLSIWGDIGLSVTALVEELtRQDSCWKYSGVKQEIREKIQLNQTRLLRKEKTRGAQLNYNQVYGTLRPLIDDYRTILVT 391
Cdd:PRK06965 332 VDIPIVGDVKEVLKELIEQL-QTAEHGPDADALAQWWKQIEGWRSRDCLKYDRESEIIKPQYVVEKLWELTDGDAFVCSD 410
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 392 EGANTMDIARIsFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVIVVM 471
Cdd:PRK06965 411 VGQHQMWAAQF-YRFNEPRRWINSGGLGTMGVGLPYAMGIKMAHPDDDVVCITGEGSIQMCIQELSTCLQYDTPVKIISL 489
|
..
gi 6320816 472 NN 473
Cdd:PRK06965 490 NN 491
|
|
| TPP_enzymes |
cd00568 |
Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic ... |
373-542 |
1.38e-23 |
|
Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and the branched chain alpha-keto acid dehydrogenase complexes.
Pssm-ID: 238318 [Multi-domain] Cd Length: 168 Bit Score: 97.33 E-value: 1.38e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 373 QVYGTLRPLIDDyRTILVTEGANTMDIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFS 452
Cdd:cd00568 1 RVLAALRAALPE-DAIVVNDAGNSAYWAYRYLPLRRGRRFLTSTGFGAMGYGLPAAIGAALAAPDRPVVCIAGDGGFMMT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 453 AMEIETAVRCQLALVIVVMNNSG---IYHGEKDIEGDLPPTALSKNCRYDLVGKGLGANDFFVNTISELSRCFQQAvqls 529
Cdd:cd00568 80 GQELATAVRYGLPVIVVVFNNGGygtIRMHQEAFYGGRVSGTDLSNPDFAALAEAYGAKGVRVEDPEDLEAALAEA---- 155
|
170
....*....|...
gi 6320816 530 RTKRETSVINVII 542
Cdd:cd00568 156 LAAGGPALIEVKT 168
|
|
| PRK09107 |
PRK09107 |
acetolactate synthase 3 catalytic subunit; Validated |
11-473 |
2.85e-23 |
|
acetolactate synthase 3 catalytic subunit; Validated
Pssm-ID: 236380 [Multi-domain] Cd Length: 595 Bit Score: 103.63 E-value: 2.85e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 11 QLLQKYGIDTVFGIVGIPIVQLADTMVA-NGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSMS 89
Cdd:PRK09107 19 QALKDQGVEHIFGYPGGAVLPIYDEIFQqDDIQHILVRHEQGAGHAAEGYARSTGKPGVVLVTSGPGATNAVTPLQDALM 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 90 NRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGkLTPDNIDM--ITQKALNYCIQGTAGVSYIDVPAD--FI-- 163
Cdd:PRK09107 99 DSIPLVCITGQVPTHLIGSDAFQECDTVGITRPCTKHNW-LVKDVNDLarVIHEAFHVATSGRPGPVVVDIPKDvqFAtg 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 164 EYEKPLEGNDRTGnelpmiLTPNICGpDPSKIKKVVQLILQHKNKniLIVIGKGAV----KNSHEIRRLVNTFNLPFLPT 239
Cdd:PRK09107 178 TYTPPQKAPVHVS------YQPKVKG-DAEAITEAVELLANAKRP--VIYSGGGVInsgpEASRLLRELVELTGFPITST 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 240 PMAKGIVPDSSP-------LNVSSARSQALKIADIVLVLGARLN-----WILHFgtSPkwNSESIFIQFDsnPETLgDNN 307
Cdd:PRK09107 249 LMGLGAYPASGKnwlgmlgMHGTYEANMAMHDCDVMLCVGARFDdritgRLDAF--SP--NSKKIHIDID--PSSI-NKN 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 308 VSpgADLSIWGDIGlsvtALVEELTRqdsCWKYSGVKQEiREKIQLNQTRLlrkEKTRGAQ-LNYNQVYGTLRP------ 380
Cdd:PRK09107 322 VR--VDVPIIGDVG----HVLEDMLR---LWKARGKKPD-KEALADWWGQI---ARWRARNsLAYTPSDDVIMPqyaiqr 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 381 ---LIDDYRTILVTE-GANTMDIARIsFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEI 456
Cdd:PRK09107 389 lyeLTKGRDTYITTEvGQHQMWAAQF-FGFEEPNRWMTSGGLGTMGYGLPAALGVQIAHPDALVIDIAGDASIQMCIQEM 467
|
490
....*....|....*..
gi 6320816 457 ETAVRCQLALVIVVMNN 473
Cdd:PRK09107 468 STAVQYNLPVKIFILNN 484
|
|
| PRK11269 |
PRK11269 |
glyoxylate carboligase; Provisional |
4-543 |
1.17e-22 |
|
glyoxylate carboligase; Provisional
Pssm-ID: 183066 [Multi-domain] Cd Length: 591 Bit Score: 101.98 E-value: 1.17e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 4 TATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANG-IKFIPCRNEQAASYAASayGYISDKPG---VLLIVGGPGLIH 79
Cdd:PRK11269 5 RAVDAAVLVLEKEGVTTAFGVPGAAINPFYSAMRKHGgIRHILARHVEGASHMAE--GYTRATAGnigVCIGTSGPAGTD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 80 ALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKF-TGKLTPDNIDMITQKALNYCIQGTAGVSYIDV 158
Cdd:PRK11269 83 MITGLYSASADSIPILCITGQAPRARLHKEDFQAVDIESIAKPVTKWaVTVREPALVPRVFQQAFHLMRSGRPGPVLIDL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 159 PADF----IEYEkplegnDRTGNELPmILTPnicGPDPSKIKKVVQLILQHKNKniLIVIGkGAVKN---SHEIRRLVNT 231
Cdd:PRK11269 163 PFDVqvaeIEFD------PDTYEPLP-VYKP---AATRAQIEKALEMLNAAERP--LIVAG-GGVINadaSDLLVEFAEL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 232 FNLPFLPTPMAKGIVPDSSPLNV------SSAR--SQALKIADIVLVLGARlnWI-LHFGTSPKWNSESIFIQFDSNPET 302
Cdd:PRK11269 230 TGVPVIPTLMGWGAIPDDHPLMAgmvglqTSHRygNATLLASDFVLGIGNR--WAnRHTGSVEVYTKGRKFVHVDIEPTQ 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 303 LGdnNVSpGADLSIWGDIGLSVTALVeELTRQdscWKYSGVKQEIREKIQLNQTR---LLRKEKTRGAQLNYNQVYGTLR 379
Cdd:PRK11269 308 IG--RVF-GPDLGIVSDAKAALELLV-EVARE---WKAAGRLPDRSAWVADCQERkrtLLRKTHFDNVPIKPQRVYEEMN 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 380 PLIDDyRTILVTeganTMDIARIS----FPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFsaME 455
Cdd:PRK11269 381 KAFGR-DTCYVS----TIGLSQIAaaqfLHVYKPRHWINCGQAGPLGWTIPAALGVRAADPDRNVVALSGDYDFQF--LI 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 456 IETAVRCQLAL--VIVVMNNSgiYHG---------EKDIEGDL------PPTALSKNCRYDLVGKGLGANDFFVNTISEL 518
Cdd:PRK11269 454 EELAVGAQFNLpyIHVLVNNA--YLGlirqaqrafDMDYCVQLafeninSPELNGYGVDHVKVAEGLGCKAIRVFKPEDI 531
|
570 580
....*....|....*....|....*
gi 6320816 519 SRCFQQAVQLSRTKRETSVINVIIE 543
Cdd:PRK11269 532 APALEQAKALMAEFRVPVVVEVILE 556
|
|
| PRK07710 |
PRK07710 |
acetolactate synthase large subunit; |
2-473 |
1.19e-22 |
|
acetolactate synthase large subunit;
Pssm-ID: 236076 [Multi-domain] Cd Length: 571 Bit Score: 101.76 E-value: 1.19e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 2 TTTATQHFAQLL----QKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGL 77
Cdd:PRK07710 11 TEEKLMTGAQMLiealEKEGVEVIFGYPGGAVLPLYDALYDCGIPHILTRHEQGAIHAAEGYARISGKPGVVIATSGPGA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 78 IHALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKL-TPDNIDMITQKALNYCIQGTAGVSYI 156
Cdd:PRK07710 91 TNVVTGLADAMIDSLPLVVFTGQVATSVIGSDAFQEADIMGITMPVTKHNYQVrKASDLPRIIKEAFHIATTGRPGPVLI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 157 DVPADFIEYEKPLEGNDRTgnELPMiLTPNIcGPDPSKIKKVVQLILQHKNKNILIVIGKGAVKNSHEIRRLVNTFNLPF 236
Cdd:PRK07710 171 DIPKDMVVEEGEFCYDVQM--DLPG-YQPNY-EPNLLQIRKLVQAVSVAKKPVILAGAGVLHAKASKELTSYAEQQEIPV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 237 LPTPMAKGIVPDSSPLNV-------SSARSQALKIADIVLVLGARLNWILHfGTSPKWNSESIFIQFDSNPETLGDNNVS 309
Cdd:PRK07710 247 VHTLLGLGGFPADHPLFLgmagmhgTYTANMALYECDLLINIGARFDDRVT-GNLAYFAKEATVAHIDIDPAEIGKNVPT 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 310 pgaDLSIWGDIGLSVTALVEELTRQD--SCWKYsgvkqeirekiQLNQtrllRKEKTrgaQLNYNQVYGTLRP--LIDDY 385
Cdd:PRK07710 326 ---EIPIVADAKQALQVLLQQEGKKEnhHEWLS-----------LLKN----WKEKY---PLSYKRNSESIKPqkAIEML 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 386 RTILVTEGANTMDI------ARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETA 459
Cdd:PRK07710 385 YEITKGEAIVTTDVgqhqmwAAQYYPFKTPDKWVTSGGLGTMGFGLPAAIGAQLAKPDETVVAIVGDGGFQMTLQELSVI 464
|
490
....*....|....
gi 6320816 460 VRCQLALVIVVMNN 473
Cdd:PRK07710 465 KELSLPVKVVILNN 478
|
|
| PDC1 |
COG3961 |
TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase [Carbohydrate ... |
1-544 |
7.93e-22 |
|
TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase [Carbohydrate transport and metabolism, Coenzyme transport and metabolism, General function prediction only]; TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase is part of the Pathway/BioSystem: Pyruvate oxidation
Pssm-ID: 443161 [Multi-domain] Cd Length: 545 Bit Score: 99.08 E-value: 7.93e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 1 MTTTATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVAN-GIKFIPCRNEQAasyaasaYGYISD-----KP-GVLLI-- 71
Cdd:COG3961 3 MTYTVGDYLLDRLAELGIRHIFGVPGDYNLPFLDAIEAHpGIRWVGCCNELN-------AGYAADgyarvNGlGALVTty 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 72 -VGGPGLIHALAGiynSMSNRWPLLVIAGSSSQSDIHKGG-------------FQELdqvsllspFLKFT---GKLTPDN 134
Cdd:COG3961 76 gVGELSAINGIAG---AYAERVPVVHIVGAPGTRAQRRGPllhhtlgdgdfdhFLRM--------FEEVTvaqAVLTPEN 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 135 IDMITQKALNYCIQGTAGVsYIDVPADFieYEKPLEgndRTGNELPMILTPnicgPDPSKIKKVVQLILQH--KNKNILI 212
Cdd:COG3961 145 AAAEIDRVLAAALREKRPV-YIELPRDV--ADAPIE---PPEAPLPLPPPA----SDPAALAAAVAAAAERlaKAKRPVI 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 213 VIGkgavknsHEIRR---------LVNTFNLPFLPTPMAKGIVPDSSPLNV---------SSARsQALKIADIVLVLGAR 274
Cdd:COG3961 215 LAG-------VEVHRfglqeellaLAEKTGIPVATTLLGKSVLDESHPQFIgtyagaassPEVR-EYVENADCVLCLGVV 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 275 LN-WILHFGTSpkwnsesifiQFDsnPE---TLGDNNVSPGAdlSIWGDIGLS--VTALVEELTRQDSCWKYSGVKQEir 348
Cdd:COG3961 287 FTdTNTGGFTA----------QLD--PErtiDIQPDSVRVGG--HIYPGVSLAdfLEALAELLKKRSAPLPAPAPPPP-- 350
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 349 ekiqlnqtrllRKEKTRGAQLNYNQVYGTLRPLIDDyRTILVTE------GANTMdiarisfptdaprrRLDAGTN---- 418
Cdd:COG3961 351 -----------PPPAAPDAPLTQDRLWQRLQAFLDP-GDIVVADtgtslfGAADL--------------RLPEGATfiaq 404
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 419 ---ATMGIG----LGYALACkashPELDVVLIQGDSAFGFSAMEIETAVRCQLALVIVVMNNSGiYHGEKDIEG------ 485
Cdd:COG3961 405 plwGSIGYTlpaaLGAALAA----PDRRVILLVGDGAFQLTAQELSTMLRYGLKPIIFVLNNDG-YTIERAIHGpdgpyn 479
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6320816 486 DLPptalskNCRYDLVGKGLGANDFF---VNTISELsrcfQQAVQLSRTKRET-SVINVIIEP 544
Cdd:COG3961 480 DIA------NWDYAKLPEAFGGGNALgfrVTTEGEL----EEALAAAEANTDRlTLIEVVLDK 532
|
|
| TPP_enzyme_C |
pfam02775 |
Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; |
393-540 |
8.92e-22 |
|
Thiamine pyrophosphate enzyme, C-terminal TPP binding domain;
Pssm-ID: 460689 [Multi-domain] Cd Length: 151 Bit Score: 91.88 E-value: 8.92e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 393 GANTMDIARIsFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVIVVMN 472
Cdd:pfam02775 3 GCHQMWAAQY-YRFRPPRRYLTSGGLGTMGYGLPAAIGAKLARPDRPVVAIAGDGGFQMNLQELATAVRYNLPITVVVLN 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6320816 473 NS--GIYHGEKDIEGDLPPTALS----KNCRYDLVGKGLGANDFFVNTISELSRCFQQAVQlsrtKRETSVINV 540
Cdd:pfam02775 82 NGgyGMTRGQQTPFGGGRYSGPSgkilPPVDFAKLAEAYGAKGARVESPEELEEALKEALE----HDGPALIDV 151
|
|
| TPP_PYR_POX |
cd07039 |
Pyrimidine (PYR) binding domain of POX; Thiamine pyrophosphate (TPP family), pyrimidine (PYR) ... |
4-162 |
1.32e-20 |
|
Pyrimidine (PYR) binding domain of POX; Thiamine pyrophosphate (TPP family), pyrimidine (PYR) binding domain of pyruvate oxidase (POX) subfamily. The PYR domain is found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. TPP binds in the cleft formed by a PYR domain and a PP domain. The PYR domain, binds the aminopyrimidine ring of TPP, the PP domain binds the diphosphate residue. The PYR and PP domains have a common fold, but do not share strong sequence conservation. The PP domain is not included in this sub-family. Most TPP-dependent enzymes have the PYR and PP domains on the same subunit although these domains can be alternatively arranged in the primary structure. TPP-dependent enzymes are multisubunit proteins, the smallest catalytic unit being a dimer-of-active sites. Lactobacillus plantarum POX is a homotetramer (dimer-of-homodimers), having two active sites per homodimer lying between PYR and PP domains of different subunits. POX decarboxylates pyruvate, producing hydrogen peroxide and the energy-storage metabolite acetylphosphate.
Pssm-ID: 132922 [Multi-domain] Cd Length: 164 Bit Score: 88.76 E-value: 1.32e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 4 TATQHFAQLLQKYGIDTVFGIVGIPIVQLADTM-VANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALA 82
Cdd:cd07039 1 TVADVIVETLENWGVKRVYGIPGDSINGLMDALrREGKIEFIQVRHEEAAAFAASAEAKLTGKLGVCLGSSGPGAIHLLN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 83 GIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKL-TPDNIDMITQKALNYCIqGTAGVSYIDVPAD 161
Cdd:cd07039 81 GLYDAKRDRAPVLAIAGQVPTDELGTDYFQEVDLLALFKDVAVYNETVtSPEQLPELLDRAIRTAI-AKRGVAVLILPGD 159
|
.
gi 6320816 162 F 162
Cdd:cd07039 160 V 160
|
|
| PRK07064 |
PRK07064 |
thiamine pyrophosphate-binding protein; |
10-475 |
2.09e-20 |
|
thiamine pyrophosphate-binding protein;
Pssm-ID: 180820 [Multi-domain] Cd Length: 544 Bit Score: 94.67 E-value: 2.09e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 10 AQLLQKYGIDTVFGIVGIPIVQLADTMVANG-IKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSM 88
Cdd:PRK07064 10 AAFLEQCGVKTAFGVISIHNMPILDAIGRRGkIRFVPARGEAGAVNMADAHARVSGGLGVALTSTGTGAGNAAGALVEAL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 89 SNRWPLLVIAGS-------SSQSDIHkggfQELDQVSllspFLKFTGK-----LTPDNIDMITQKALNYCIQGTAGVSYI 156
Cdd:PRK07064 90 TAGTPLLHITGQietpyldQDLGYIH----EAPDQLT----MLRAVSKaafrvRSAETALATIREAVRVALTAPTGPVSV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 157 DVPADfIEYEKplegndrtgNELPMILTP---NICGPDPSKIKKVVQLILQHKNKniLIVIGKGAVKNSHEIRRLVNtFN 233
Cdd:PRK07064 162 EIPID-IQAAE---------IELPDDLAPvhvAVPEPDAAAVAELAERLAAARRP--LLWLGGGARHAGAEVKRLVD-LG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 234 LPFLPTPMAKGIVPDSSP-----LNVSSARSQALKIADIVLVLGARL------NWILHFGTSpkwnsesiFIQFDSNPET 302
Cdd:PRK07064 229 FGVVTSTQGRGVVPEDHPaslgaFNNSAAVEALYKTCDLLLVVGSRLrgnetlKYSLALPRP--------LIRVDADAAA 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 303 LGDNNVspgADLSIWGDIGLSVTALVEELtrqdscwkysgvkqEIREKIQLNQTRLLR--KEKTRGAQLNYNQVYGTlrp 380
Cdd:PRK07064 301 DGRGYP---NDLFVHGDAARVLARLADRL--------------EGRLSVDPAFAADLRaaREAAVADLRKGLGPYAK--- 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 381 LIDDYRTILVTEGANTMDIArIS--------FPTDAPRrrldAGTNATMG-IGLGYALACKAS--HPELDVVLIQGDSAF 449
Cdd:PRK07064 361 LVDALRAALPRDGNWVRDVT-ISnstwgnrlLPIFEPR----ANVHALGGgIGQGLAMAIGAAlaGPGRKTVGLVGDGGL 435
|
490 500
....*....|....*....|....*.
gi 6320816 450 GFSAMEIETAVRCQLALVIVVMNNSG 475
Cdd:PRK07064 436 MLNLGELATAVQENANMVIVLMNDGG 461
|
|
| PLN02470 |
PLN02470 |
acetolactate synthase |
11-473 |
4.03e-20 |
|
acetolactate synthase
Pssm-ID: 215261 [Multi-domain] Cd Length: 585 Bit Score: 94.03 E-value: 4.03e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 11 QLLQKYGIDTVFGIVGIPIVQLADTMV-ANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSMS 89
Cdd:PLN02470 21 EALEREGVDTVFAYPGGASMEIHQALTrSNCIRNVLCRHEQGEVFAAEGYAKASGKVGVCIATSGPGATNLVTGLADALL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 90 NRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTG-KLTPDNIDMITQKALNYCIQGTAGVSYIDVPADFIE---- 164
Cdd:PLN02470 101 DSVPLVAITGQVPRRMIGTDAFQETPIVEVTRSITKHNYlVMDVEDIPRVIREAFFLASSGRPGPVLVDIPKDIQQqlav 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 165 --YEKPLEGNDRTgNELPMIltpnicgPDPSKIKKVVQLIlqHKNKNILIVIGKGAVKNSHEIRRLVNTFNLPFLPTPMA 242
Cdd:PLN02470 181 pnWNQPMKLPGYL-SRLPKP-------PEKSQLEQIVRLI--SESKRPVVYVGGGCLNSSEELREFVELTGIPVASTLMG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 243 KGIVPDSSPLNVSS-------ARSQALKIADIVLVLGARLNWILHfGTSPKWNSESIFIQFDSNPETLGDNNvspGADLS 315
Cdd:PLN02470 251 LGAFPASDELSLQMlgmhgtvYANYAVDSADLLLAFGVRFDDRVT-GKLEAFASRASIVHIDIDPAEIGKNK---QPHVS 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 316 IWGDIGLSVTALVEEL-TRQDSCWKYSGVKQEIREKIQLNQTRLlrkeKTRGAQLNYNQVYGTLRPLIDDYRTILVTEGA 394
Cdd:PLN02470 327 VCADVKLALQGLNKLLeERKAKRPDFSAWRAELDEQKEKFPLSY----PTFGDAIPPQYAIQVLDELTDGNAIISTGVGQ 402
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6320816 395 NTMDIARIsFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVIVVMNN 473
Cdd:PLN02470 403 HQMWAAQW-YKYKEPRRWLTSGGLGAMGFGLPAAIGAAAANPDAIVVDIDGDGSFIMNIQELATIHVENLPVKIMVLNN 480
|
|
| PRK08199 |
PRK08199 |
thiamine pyrophosphate protein; Validated |
1-544 |
3.46e-19 |
|
thiamine pyrophosphate protein; Validated
Pssm-ID: 181285 [Multi-domain] Cd Length: 557 Bit Score: 91.09 E-value: 3.46e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 1 MTTTATQHFAQLLQKYGIDTVFGIVG---IPIVQ-LADtmvANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPG 76
Cdd:PRK08199 6 RARTGGQILVDALRANGVERVFCVPGesyLAVLDaLHD---ETDIRVIVCRQEGGAAMMAEAYGKLTGRPGICFVTRGPG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 77 LIHALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSY 155
Cdd:PRK08199 83 ATNASIGVHTAFQDSTPMILFVGQVARDFREREAFQEIDYRRMFGPMAKWVAEIDdAARIPELVSRAFHVATSGRPGPVV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 156 IDVPADFieyekpLEGNDRTGNELPMilTPNICGPDPSKIKKVVQLILQHKnKNILIVIGKG----AVKnshEIRRLVNT 231
Cdd:PRK08199 163 LALPEDV------LSETAEVPDAPPY--RRVAAAPGAADLARLAELLARAE-RPLVILGGSGwteaAVA---DLRAFAER 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 232 FNLPFLPTPMAKGIVPDSSP-------LNVSSARSQALKIADIVLVLGARLNWILHFG----TSPKwnSESIFIQFDSNP 300
Cdd:PRK08199 231 WGLPVACAFRRQDLFDNRHPnyagdlgLGINPALAARIREADLVLAVGTRLGEVTTQGytllDIPV--PRQTLVHVHPDA 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 301 ETLGdnNVSPgADLSIWGDIGLSVTALVEELTRQDSCWKysGVKQEIREKIQLNQTRLLrkekTRGAqLNYNQVYGTLRP 380
Cdd:PRK08199 309 EELG--RVYR-PDLAIVADPAAFAAALAALEPPASPAWA--EWTAAAHADYLAWSAPLP----GPGA-VQLGEVMAWLRE 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 381 -LIDDyrTIlVTEGA-NTMDIARISFPTDAPRRRLdAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIET 458
Cdd:PRK08199 379 rLPAD--AI-ITNGAgNYATWLHRFFRFRRYRTQL-APTSGSMGYGLPAAIAAKLLFPERTVVAFAGDGCFLMNGQELAT 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 459 AVRCQLALVIVVMNNsGIY-----HGEKDIEGDLPPTALsKNCRYDLVGKGLGANDFFVNTISElsrcFQQAVQLSRTKR 533
Cdd:PRK08199 455 AVQYGLPIIVIVVNN-GMYgtirmHQEREYPGRVSGTDL-TNPDFAALARAYGGHGETVERTED----FAPAFERALASG 528
|
570
....*....|.
gi 6320816 534 ETSVINVIIEP 544
Cdd:PRK08199 529 KPALIEIRIDP 539
|
|
| TPP_POX |
cd02014 |
Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; ... |
369-546 |
6.57e-18 |
|
Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates pyruvate, producing hydrogen peroxide and the energy-storage metabolite acetylphosphate. It requires FAD in addition to TPP and a divalent cation as cofactors.
Pssm-ID: 238972 [Multi-domain] Cd Length: 178 Bit Score: 81.42 E-value: 6.57e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 369 LNYNQVYGTLRPLIDDyRTILVTE-GANTMDIARiSFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDS 447
Cdd:cd02014 2 IHPERVAAELNKRAPD-DAIFTIDvGNVTVWAAR-HLRMNGKQRFILSGLLATMGNGLPGAIAAKLAYPDRQVIALSGDG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 448 AFGFSAMEIETAVRCQLALVIVVMNNS--GIYHGEKDIEGDLP-PTALSkNCRYDLVGKGLGANDFFVNTISELSRCFQQ 524
Cdd:cd02014 80 GFAMLMGDLITAVKYNLPVIVVVFNNSdlGFIKWEQEVMGQPEfGVDLP-NPDFAKIAEAMGIKGIRVEDPDELEAALDE 158
|
170 180
....*....|....*....|..
gi 6320816 525 AVQLSRtkreTSVINVIIEPGE 546
Cdd:cd02014 159 ALAADG----PVVIDVVTDPNE 176
|
|
| TPP_Xsc_like |
cd02013 |
Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of ... |
366-545 |
3.49e-17 |
|
Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the desulfonation of 2-sulfoacetaldehyde into sulfite and acetyl phosphate. This enzyme requires TPP and divalent metal ions for activity.
Pssm-ID: 238971 [Multi-domain] Cd Length: 196 Bit Score: 79.86 E-value: 3.49e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 366 GAQLNYNQVYGTLRPLIDDyRTILVTEGANTMDIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQG 445
Cdd:cd02013 1 GNPMHPRQVLRELEKAMPE-DAIVSTDIGNICSVANSYLRFEKPRSFIAPLSFGNCGYALPAIIGAKAAAPDRPVVAIAG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 446 DSAFGFSAMEIETAVRCQLALVIVVMNNSG---------IYHGEKDIEGDLPPTalskncRYDLVGKGLGANDFFVNTIS 516
Cdd:cd02013 80 DGAWGMSMMEIMTAVRHKLPVTAVVFRNRQwgaekknqvDFYNNRFVGTELESE------SFAKIAEACGAKGITVDKPE 153
|
170 180
....*....|....*....|....*....
gi 6320816 517 ELSRCFQQAVQLsRTKRETSVINVIIEPG 545
Cdd:cd02013 154 DVGPALQKAIAM-MAEGKTTVIEIVCDQE 181
|
|
| TPP_ALS |
cd02010 |
Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; ... |
378-475 |
2.81e-16 |
|
Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2 molecules of pyruvate to acetolactate and carbon dioxide. ALS does not contain FAD, and requires TPP and a divalent metal cation for activity.
Pssm-ID: 238968 [Multi-domain] Cd Length: 177 Bit Score: 76.94 E-value: 2.81e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 378 LRPLIDDYRTILVTEGANTMDIARIsFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIE 457
Cdd:cd02010 8 LRAVMGDDDIVLLDVGAHKIWMARY-YRTYAPNTCLISNGLATMGVALPGAIGAKLVYPDRKVVAVSGDGGFMMNSQELE 86
|
90
....*....|....*...
gi 6320816 458 TAVRCQLALVIVVMNNSG 475
Cdd:cd02010 87 TAVRLKIPLVVLIWNDNG 104
|
|
| PRK08978 |
PRK08978 |
acetolactate synthase 2 catalytic subunit; Reviewed |
7-474 |
1.85e-15 |
|
acetolactate synthase 2 catalytic subunit; Reviewed
Pssm-ID: 181601 [Multi-domain] Cd Length: 548 Bit Score: 79.15 E-value: 1.85e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 7 QHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYN 86
Cdd:PRK08978 5 QWVVHALRAQGVDTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARATGKVGVCIATSGPGATNLITGLAD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 87 SMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYIDVPADFIEY 165
Cdd:PRK08978 85 ALLDSVPVVAITGQVSSPLIGTDAFQEIDVLGLSLACTKHSFLVQsLEELPEIMAEAFEIASSGRPGPVLVDIPKDIQLA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 166 EKPLEGNDRTGNELPMiltpnicgPDPSKIKKVVQLILQHKnKNILIVIG----KGAVknsHEIRRLVNTFNLPFLPTPM 241
Cdd:PRK08978 165 EGELEPHLTTVENEPA--------FPAAELEQARALLAQAK-KPVLYVGGgvgmAGAV---PALREFLAATGMPAVATLK 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 242 AKGIVPDSSPLNV-------SSARSQALKIADIVLVLGAR--------LNwilHFGTSPKwnsesiFIQFDSNPETLGDN 306
Cdd:PRK08978 233 GLGAVEADHPYYLgmlgmhgTKAANLAVQECDLLIAVGARfddrvtgkLN---TFAPHAK------VIHLDIDPAEINKL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 307 NVspgADLSIWGDIGLSVTALVEELT-----------RQDSCWKYSGVKQEIREKIQLNQtrlLRKEKTrgaqlnynqvy 375
Cdd:PRK08978 304 RQ---AHVALQGDLNALLPALQQPLNidawrqhcaqlRAEHAWRYDHPGEAIYAPALLKQ---LSDRKP----------- 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 376 gtlrpliddYRTILVTE-GANTMDIAR-ISFptDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSA 453
Cdd:PRK08978 367 ---------ADTVVTTDvGQHQMWVAQhMRF--TRPENFITSSGLGTMGFGLPAAIGAQVARPDDTVICVSGDGSFMMNV 435
|
490 500
....*....|....*....|.
gi 6320816 454 MEIETAVRCQLALVIVVMNNS 474
Cdd:PRK08978 436 QELGTIKRKQLPVKIVLLDNQ 456
|
|
| PRK09124 |
PRK09124 |
ubiquinone-dependent pyruvate dehydrogenase; |
1-474 |
4.27e-14 |
|
ubiquinone-dependent pyruvate dehydrogenase;
Pssm-ID: 181661 [Multi-domain] Cd Length: 574 Bit Score: 75.02 E-value: 4.27e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 1 MTTTATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANG-IKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIH 79
Cdd:PRK09124 1 MKQTVADYIAKTLEQAGVKRIWGVTGDSLNGLSDSLRRMGtIEWMHTRHEEVAAFAAGAEAQLTGELAVCAGSCGPGNLH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 80 ALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLL---SPFLKFTGklTPDNIDMITQKALNYCIqGTAGVSYI 156
Cdd:PRK09124 81 LINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQELFrecSHYCELVS--NPEQLPRVLAIAMRKAI-LNRGVAVV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 157 DVPADFIEYEKPLEGNDR-TGNELPMILtpnicgPDPSKIKKVVQLIlqHKNKNILIVIGKGAVKNSHEIRRLVNTFNLP 235
Cdd:PRK09124 158 VLPGDVALKPAPERATPHwYHAPQPVVT------PAEEELRKLAALL--NGSSNITLLCGSGCAGAHDELVALAETLKAP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 236 FLPTPMAKGIVPDSSPLNVS-------SARSQALKIADIVLVLGARlnwilhFGTSPKWNSESIFIQFDSNPETLGDNnv 308
Cdd:PRK09124 230 IVHALRGKEHVEYDNPYDVGmtgligfSSGYHAMMNCDTLLMLGTD------FPYRQFYPTDAKIIQIDINPGSLGRR-- 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 309 SPgADLSIWGDIGLSVTALVEELTRQDScwkysgvkQEIREKiQLNQTRLLRKEKTRGAQLNYNQvygtlRPLIDDYRTI 388
Cdd:PRK09124 302 SP-VDLGLVGDVKATLAALLPLLEEKTD--------RKFLDK-ALEHYRKARKGLDDLAVPSDGG-----KPIHPQYLAR 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 389 LVTEGANtmDIARISFPTDAP------------RRRLDAGTN-ATMGIGLGYALACKASHPELDVVLIQGDSafGFSAM- 454
Cdd:PRK09124 367 QISEFAA--DDAIFTCDVGTPtvwaarylkmngKRRLLGSFNhGSMANAMPQALGAQAAHPGRQVVALSGDG--GFSMLm 442
|
490 500
....*....|....*....|.
gi 6320816 455 -EIETAVRCQLALVIVVMNNS 474
Cdd:PRK09124 443 gDFLSLVQLKLPVKIVVFNNS 463
|
|
| TPP_AHAS |
cd02015 |
Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding ... |
373-546 |
1.25e-13 |
|
Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the acetohydroxyacid, 2-acetolactate. 2-Acetolactate is the precursor of the branched chain amino acids, valine and leucine. AHAS also catalyzes the condensation of pyruvate and 2-ketobutyrate to form 2-aceto-2-hydroxybutyrate in isoleucine biosynthesis. In addition to requiring TPP and a divalent metal ion as cofactors, AHAS requires FAD.
Pssm-ID: 238973 [Multi-domain] Cd Length: 186 Bit Score: 69.45 E-value: 1.25e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 373 QVYGTLRPLIDDyRTILVTE-GANTMDIARiSFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGF 451
Cdd:cd02015 5 EVIKELSELTPG-DAIVTTDvGQHQMWAAQ-YYRFKKPRSWLTSGGLGTMGFGLPAAIGAKVARPDKTVICIDGDGSFQM 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 452 SAMEIETAVRCQLALVIVVMNNSG---------IYHGEKDIEgdlppTALSKNCRYDLVGKGLGANDFFVNTISELSRCF 522
Cdd:cd02015 83 NIQELATAAQYNLPVKIVILNNGSlgmvrqwqeLFYEGRYSH-----TTLDSNPDFVKLAEAYGIKGLRVEKPEELEAAL 157
|
170 180
....*....|....*....|....
gi 6320816 523 QQAVQlsrtKRETSVINVIIEPGE 546
Cdd:cd02015 158 KEALA----SDGPVLLDVLVDPEE 177
|
|
| PRK06546 |
PRK06546 |
pyruvate dehydrogenase; Provisional |
1-474 |
1.32e-12 |
|
pyruvate dehydrogenase; Provisional
Pssm-ID: 180614 [Multi-domain] Cd Length: 578 Bit Score: 70.40 E-value: 1.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 1 MTTTATQhFAQLLQKYGIDTVFGIVGI---PIVQLADTmvANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGL 77
Cdd:PRK06546 2 AKTVAEQ-LVEQLVAAGVKRIYGIVGDslnPIVDAVRR--TGGIEWVHVRHEEAAAFAAAAEAQLTGKLAVCAGSCGPGN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 78 IHALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDqvsllspflkftgkltPDNI--------DMITQKA-----LN 144
Cdd:PRK06546 79 LHLINGLYDAHRSGAPVLAIASHIPSAQIGSGFFQETH----------------PDRLfvecsgycEMVSSAEqaprvLH 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 145 YCIQ---GTAGVSYIDVPADFIEYEKPlegndRTGNELPMILTPNICGPDPSKIKKVVQLIlqHKNKNILIVIGKGaVKN 221
Cdd:PRK06546 143 SAIQhavAGGGVSVVTLPGDIADEPAP-----EGFAPSVISPRRPTVVPDPAEVRALADAI--NEAKKVTLFAGAG-VRG 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 222 SH-EIRRLVNTFNLPFLPTPMAKGIVPDSSPLNVS-------SARSQALKIADIVLVLGARL--NWILhfgtsPKWNSes 291
Cdd:PRK06546 215 AHaEVLALAEKIKAPVGHSLRGKEWIQYDNPFDVGmsgllgyGAAHEAMHEADLLILLGTDFpyDQFL-----PDVRT-- 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 292 ifIQFDSNPETLGDNNvspGADLSIWGDIGLSVTALVEELTRQDScwkysgvkQEIREKIQLNQTRLLrkEKTRGAqlnY 371
Cdd:PRK06546 288 --AQVDIDPEHLGRRT---RVDLAVHGDVAETIRALLPLVKEKTD--------RRFLDRMLKKHARKL--EKVVGA---Y 349
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 372 NQVYGTLRPLIDDYRTILVTEGAN-----TMDI-------ARisFPTDAPRRR-LDAGTNATMGIGLGYALACKASHPEL 438
Cdd:PRK06546 350 TRKVEKHTPIHPEYVASILDELAAddavfTVDTgmcnvwaAR--YITPNGRRRvIGSFRHGSMANALPHAIGAQLADPGR 427
|
490 500 510
....*....|....*....|....*....|....*.
gi 6320816 439 DVVLIQGDSAFGFSAMEIETAVRCQLALVIVVMNNS 474
Cdd:PRK06546 428 QVISMSGDGGLSMLLGELLTVKLYDLPVKVVVFNNS 463
|
|
| TPP_PDC_IPDC |
cd02005 |
Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of ... |
420-546 |
5.72e-10 |
|
Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of pyruvate to acetaldehyde and CO2. It is able to utilize other 2-oxo acids as substrates. In plants and various plant-associated bacteria, IPDC plays a role in the indole-3-pyruvic acid (IPA) pathway, a tryptophan-dependent biosynthetic route to indole-3-acetaldehyde (IAA). IPDC catalyzes the decarboxylation of IPA to IAA. Both PDC and IPDC depend on TPP and Mg2+ as cofactors.
Pssm-ID: 238963 [Multi-domain] Cd Length: 183 Bit Score: 58.70 E-value: 5.72e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 420 TMGIGLGYALAckasHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVIVVMNNSGiYHGEKDIEGDLPPTALSKNCRYD 499
Cdd:cd02005 55 SVPAALGAALA----APDRRVILLVGDGSFQMTVQELSTMIRYGLNPIIFLINNDG-YTIERAIHGPEASYNDIANWNYT 129
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 6320816 500 LVGKGLGAND----FFVNTISELsrcfQQAVQLSRTKRET-SVINVIIEPGE 546
Cdd:cd02005 130 KLPEVFGGGGgglsFRVKTEGEL----DEALKDALFNRDKlSLIEVILPKDD 177
|
|
| TPP_IolD |
cd02003 |
Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins ... |
371-544 |
1.89e-09 |
|
Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism.
Pssm-ID: 238961 [Multi-domain] Cd Length: 205 Bit Score: 57.70 E-value: 1.89e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 371 YNQVYGTLRPLIDDYRTILVTEGANTMDIARIsFPTDAPRR-RLDAGTnATMGIGLGYALACKASHPELDVVLIQGDSAF 449
Cdd:cd02003 1 QTEVLGALNEAIGDDDVVINAAGSLPGDLHKL-WRARTPGGyHLEYGY-SCMGYEIAAGLGAKLAKPDREVYVLVGDGSY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 450 GFSAMEIETAVRCQLALVIVVMNNSGiY-----------------------HGEKDIEGDLPPTALSKNCRydlvgkGLG 506
Cdd:cd02003 79 LMLHSEIVTAVQEGLKIIIVLFDNHG-FgcinnlqestgsgsfgtefrdrdQESGQLDGALLPVDFAANAR------SLG 151
|
170 180 190
....*....|....*....|....*....|....*...
gi 6320816 507 ANDFFVNTISElsrcFQQAVQLSRTKRETSVINVIIEP 544
Cdd:cd02003 152 ARVEKVKTIEE----LKAALAKAKASDRTTVIVIKTDP 185
|
|
| PRK08273 |
PRK08273 |
thiamine pyrophosphate protein; Provisional |
1-473 |
2.77e-09 |
|
thiamine pyrophosphate protein; Provisional
Pssm-ID: 181344 [Multi-domain] Cd Length: 597 Bit Score: 59.92 E-value: 2.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 1 MTTTATQHFAQLLQKYGIDTVFGIVGIPIVQLadtMVA-----NGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGP 75
Cdd:PRK08273 1 MSQTVADFILERLREWGVRRVFGYPGDGINGL---LGAlgradDKPEFVQARHEEMAAFMAVAHAKFTGEVGVCLATSGP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 76 GLIHALAGIYNSMSNRWPLLVIAGSSSQSDIhkGGF--QELDQVSLL----SPFLKFTgkLTPDNIDMITQKALNYCIqG 149
Cdd:PRK08273 78 GAIHLLNGLYDAKLDHVPVVAIVGQQARAAL--GGHyqQEVDLQSLFkdvaGAFVQMV--TVPEQLRHLVDRAVRTAL-A 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 150 TAGVSYIDVPADF--IEYEKPLE--GNDRTGnelPMILTPNICgPDPSKIKKVVQLIlqHKNKNILIVIGKGAVKNSHEI 225
Cdd:PRK08273 153 ERTVTAVILPNDVqeLEYEPPPHahGTVHSG---VGYTRPRVV-PYDEDLRRAAEVL--NAGRKVAILVGAGALGATDEV 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 226 RRLVNTFNLPFLPTPMAKGIVPDSSPlnvssarsqalkiadivLVLGArlnwILHFGTSPKWN----------------- 288
Cdd:PRK08273 227 IAVAERLGAGVAKALLGKAALPDDLP-----------------WVTGS----IGLLGTKPSYElmrecdtllmvgssfpy 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 289 SEsiF---------IQFDSNPETLGdnNVSPgADLSIWGDIGLSVTALVEELTR-QDSCWkysgvkqeiREKIQLNQTR- 357
Cdd:PRK08273 286 SE--FlpkegqargVQIDIDGRMLG--LRYP-MEVNLVGDAAETLRALLPLLERkKDRSW---------RERIEKWVARw 351
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 358 --LLRKEKTRGAQ-LNYNQVYGTLRPLIDDyRTILVTE-GANTMDIAR-ISFptdapRRRLDA---GTNATMGIGLGYAL 429
Cdd:PRK08273 352 weTLEARAMVPADpVNPQRVFWELSPRLPD-NAILTADsGSCANWYARdLRM-----RRGMMAslsGTLATMGPAVPYAI 425
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 6320816 430 ACKASHPELDVVLIQGDSAFGFSAM-EIETAVRC--QLA---LVIVVMNN 473
Cdd:PRK08273 426 AAKFAHPDRPVIALVGDGAMQMNGMaELITVAKYwrQWSdprLIVLVLNN 475
|
|
| TPP_BFDC |
cd02002 |
Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins ... |
377-542 |
3.63e-09 |
|
Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of benzoylformate to benzaldehyde and carbon dioxide. This enzyme is dependent on TPP and a divalent metal cation as cofactors.
Pssm-ID: 238960 [Multi-domain] Cd Length: 178 Bit Score: 56.45 E-value: 3.63e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 377 TLRPLIDDyRTILVTEGANTMDIARISFPTDAPRRRLdagTNATMGIG------LGYALACkashPELDVVLIQGDSAFG 450
Cdd:cd02002 9 ALAAALPE-DAIIVDEAVTNGLPLRDQLPLTRPGSYF---TLRGGGLGwglpaaVGAALAN----PDRKVVAIIGDGSFM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 451 FSAMEIETAVRCQLALVIVVMNNSG----------IYHGEKDIEGDLPPTALSKNCRYDLVGKGLGANDFFVNTISELSR 520
Cdd:cd02002 81 YTIQALWTAARYGLPVTVVILNNRGygalrsflkrVGPEGPGENAPDGLDLLDPGIDFAAIAKAFGVEAERVETPEELDE 160
|
170 180
....*....|....*....|..
gi 6320816 521 CFQQAVqlsrTKRETSVINVII 542
Cdd:cd02002 161 ALREAL----AEGGPALIEVVV 178
|
|
| TPP_enzyme_PYR |
cd06586 |
Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Thiamine ... |
9-160 |
4.35e-07 |
|
Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Thiamine pyrophosphate (TPP) family, pyrimidine (PYR) binding domain; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. TPP binds in the cleft formed by a PYR domain and a PP domain. The PYR domain, binds the aminopyrimidine ring of TPP, the PP domain binds the diphosphate residue. A polar interaction between the conserved glutamate of the PYR domain and the N1' of the TPP aminopyrimidine ring is shared by most TPP-dependent enzymes, and participates in the activation of TPP. The PYR and PP domains have a common fold, but do not share strong sequence conservation. The PP domain is not included in this group. Most TPP-dependent enzymes have the PYR and PP domains on the same subunit although these domains can be alternatively arranged in the primary structure. In the case of 2-oxoisovalerate dehydrogenase (2OXO), sulfopyruvate decarboxylase (ComDE), and the E1 component of human pyruvate dehydrogenase complex (E1- PDHc) the PYR and PP domains appear on different subunits. TPP-dependent enzymes are multisubunit proteins, the smallest catalytic unit being a dimer-of-active sites. For many of these enzymes the active sites lie between PP and PYR domains on different subunits. However, for the homodimeric enzymes 1-deoxy-D-xylulose 5-phosphate synthase (DXS) and Desulfovibrio africanus pyruvate:ferredoxin oxidoreductase (PFOR), each active site lies at the interface of the PYR and PP domains from the same subunit.
Pssm-ID: 132915 [Multi-domain] Cd Length: 154 Bit Score: 49.65 E-value: 4.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 9 FAQLLQKYGIDTVFGIVGIPIVQLADTMVAN-GIKFIPCRNEQAASYAASayGY-ISDKPGVLLIVGGPGLIHALAGIYN 86
Cdd:cd06586 3 FAEVLTAWGVRHVFGYPGDEISSLLDALREGdKRIIDTVIHELGAAGAAA--GYaRAGGPPVVIVTSGTGLLNAINGLAD 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6320816 87 SMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLTPDNIDMitqKALNYCIQ---GTAGVSYIDVPA 160
Cdd:cd06586 81 AAAEHLPVVFLIGARGISAQAKQTFQSMFDLGMYRSIPEANISSPSPAELP---AGIDHAIRtayASQGPVVVRLPR 154
|
|
| TPP_PYR_PDC_IPDC_like |
cd07038 |
Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase ... |
7-109 |
1.57e-05 |
|
Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Thiamine pyrophosphate (TPP family), pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC) subfamily. The PYR domain is found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. TPP binds in the cleft formed by a PYR domain and a PP domain. The PYR domain, binds the aminopyrimidine ring of TPP, the PP domain binds the diphosphate residue. The PYR and PP domains have a common fold, but do not share strong sequence conservation. The PP domain is not included in this sub-family. Most TPP-dependent enzymes have the PYR and PP domains on the same subunit although these domains can be alternatively arranged in the primary structure. TPP-dependent enzymes are multisubunit proteins, the smallest catalytic unit being a dimer-of-active sites, for many the active sites lie between PP and PYR domains on different subunits. PDC catalyzes the conversion of pyruvate to acetaldehyde and CO2 in alcoholic fermentation. IPDC plays a role in the indole-3-pyruvic acid (IPA) pathway in plants and various plant-associated bacteria, it catalyzes the decarboxylation of IPA to IAA. Also belonging to this group is Mycobacterium tuberculosis alpha-keto acid decarboxylase (MtKDC) which participates in amino acid degradation via the Ehrlich pathway, and Lactococcus lactis branched-chain keto acid decarboxylase (KdcA) an enzyme identified as being involved in cheese ripening, which exhibits a very broad substrate range in the decarboxylation and carboligation reactions.
Pssm-ID: 132921 [Multi-domain] Cd Length: 162 Bit Score: 45.18 E-value: 1.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 7 QHFAQLLQKYGIDTVFGIVGIPIVQLADTMVAN-GIKFIPCRNEQAasyaasaYGYISD------KPGVLLIVGGPGLIH 79
Cdd:cd07038 1 EYLLERLKQLGVKHVFGVPGDYNLPLLDAIEENpGLRWVGNCNELN-------AGYAADgyarvkGLGALVTTYGVGELS 73
|
90 100 110
....*....|....*....|....*....|
gi 6320816 80 ALAGIYNSMSNRWPLLVIAGSSSQSDIHKG 109
Cdd:cd07038 74 ALNGIAGAYAEHVPVVHIVGAPSTKAQASG 103
|
|
| TPP_Gcl |
cd02006 |
Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins ... |
409-543 |
4.94e-05 |
|
Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the condensation of two molecules of glyoxylate to give tartronic semialdehyde and carbon dioxide. This enzyme requires TPP, magnesium ion and FAD as cofactors.
Pssm-ID: 238964 [Multi-domain] Cd Length: 202 Bit Score: 44.58 E-value: 4.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 409 PRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVIVVMNNSG---IYHGEKDIEG 485
Cdd:cd02006 47 PRHWINCGQAGPLGWTVPAALGVAAADPDRQVVALSGDYDFQFMIEELAVGAQHRIPYIHVLVNNAYlglIRQAQRAFDM 126
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6320816 486 DLPPTALSKNCR------YDL----VGKGLGANDFFVNTISELSRCFQQAVQLSRTKRETSVINVIIE 543
Cdd:cd02006 127 DYQVNLAFENINsselggYGVdhvkVAEGLGCKAIRVTKPEELAAAFEQAKKLMAEHRVPVVVEAILE 194
|
|
| TPP_ComE |
cd03372 |
Thiamine pyrophosphate (TPP) family, ComE subfamily, TPP-binding module; composed of proteins ... |
420-548 |
7.33e-04 |
|
Thiamine pyrophosphate (TPP) family, ComE subfamily, TPP-binding module; composed of proteins similar to Methanococcus jannaschii sulfopyruvate decarboxylase beta subunit (ComE). M. jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six alpha (D) subunits and six (E) beta subunits, which catalyzes the decarboxylation of sulfopyruvic acid to sulfoacetaldehyde in the coenzyme M pathway. ComDE requires TPP and divalent metal cation cofactors.
Pssm-ID: 239469 [Multi-domain] Cd Length: 179 Bit Score: 40.73 E-value: 7.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 420 TMG----IGLGYALACkashpELDVVLIQGDSAF--GFSAMeIETAVRCQLALVIVVMNNsGIYhGEKdieGDlPPTALS 493
Cdd:cd03372 43 SMGlassIGLGLALAQ-----PRKVIVIDGDGSLlmNLGAL-ATIAAEKPKNLIIVVLDN-GAY-GST---GN-QPTHAG 110
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 6320816 494 KNCRYDLVGKGLGANDF-FVNTISELSRCFQQAvqlsrtKRETSVINVIIEPGEQK 548
Cdd:cd03372 111 KKTDLEAVAKACGLDNVaTVASEEAFEKAVEQA------LDGPSFIHVKIKPGNTD 160
|
|
| PRK12474 |
PRK12474 |
hypothetical protein; Provisional |
2-161 |
8.33e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 139002 [Multi-domain] Cd Length: 518 Bit Score: 39.09 E-value: 8.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 2 TTTATQHFAQLLQKYGIDTVFGIVG---IPIVQLADTMvaNGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLI 78
Cdd:PRK12474 4 TMNGADSVVDTLLNCGVEVCFANPGtseMHFVAALDRV--PRMRPVLCLFEGVVTGAADGYGRIAGKPAVTLLHLGPGLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816 79 HALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYID 157
Cdd:PRK12474 82 NGLANLHNARRAASPIVNIVGDHAVEHLQYDAPLTSDIDGFARPVSRWVHRSAsAGAVDSDVARAVQAAQSAPGGIATLI 161
|
....
gi 6320816 158 VPAD 161
Cdd:PRK12474 162 MPAD 165
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