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Conserved domains on  [gi|6320816|ref|NP_010895|]
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putative indolepyruvate decarboxylase family protein [Saccharomyces cerevisiae S288C]

Protein Classification

thiamine pyrophosphate-binding protein( domain architecture ID 11414520)

thiamine pyrophosphate-binding protein similar to Streptomyces clavuligerus N(2)-(2-carboxyethyl)arginine synthase, the first enzyme in the clavulanic acid biosynthesis pathway, and to Pseudomonas fluorescens benzaldehyde lyase, which catalyzes the enantioselective carboligation of two molecules of benzaldehyde to form (R)-benzoin

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK09259 super family cl35796
putative oxalyl-CoA decarboxylase; Validated
13-544 2.49e-125

putative oxalyl-CoA decarboxylase; Validated


The actual alignment was detected with superfamily member PRK09259:

Pssm-ID: 236433 [Multi-domain]  Cd Length: 569  Bit Score: 379.33  E-value: 2.49e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    13 LQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSMSNRW 92
Cdd:PRK09259  20 LKLNGIDTIYGVVGIPITDLARLAQAEGIRYIGFRHEQSAGNAAAAAGFLTQKPGVCLTVSAPGFLNGLTALANATTNCF 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    93 PLLVIAGSSSQS--DIHKGGFQELDQVSLLSPFLKFTGK-LTPDNIDMITQKALNYCIQGTAGVSYIDVPADFIEYEKPL 169
Cdd:PRK09259 100 PMIMISGSSEREivDLQQGDYEELDQLNAAKPFCKAAFRvNRAEDIGIGVARAIRTAVSGRPGGVYLDLPAKVLAQTMDA 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   170 EGNDRT----GNELPMILtpnicgPDPSKIKKVVQLILQHKNKniLIVIGKGAV--KNSHEIRRLVNTFNLPFLPTPMAK 243
Cdd:PRK09259 180 DEALTSlvkvVDPAPAQL------PAPEAVDRALDLLKKAKRP--LIILGKGAAyaQADEQIREFVEKTGIPFLPMSMAK 251
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   244 GIVPDSSPLNVSSARSQALKIADIVLVLGARLNWILHFGTSPKWNSESIFIQFDSNPETLgDNNVSPGADLSiwGDIGLS 323
Cdd:PRK09259 252 GLLPDTHPQSAAAARSLALANADVVLLVGARLNWLLSHGKGKTWGADKKFIQIDIEPQEI-DSNRPIAAPVV--GDIGSV 328
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   324 VTALVEELTRQ----DSCWkysgvKQEIREKIQLNQTRLLRKEKTRGAQLNYNQVYGTLRPLIDDYR-TILVTEGANTMD 398
Cdd:PRK09259 329 MQALLAGLKQNtfkaPAEW-----LDALAERKEKNAAKMAEKLSTDTQPMNFYNALGAIRDVLKENPdIYLVNEGANTLD 403
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   399 IARISFPTDAPRRRLDAGTNATMGIGLGYAL--ACKASHPeldVVLIQGDSAFGFSAMEIETAVRCQLALVIVVMNNSGI 476
Cdd:PRK09259 404 LARNIIDMYKPRHRLDCGTWGVMGIGMGYAIaaAVETGKP---VVAIEGDSAFGFSGMEVETICRYNLPVTVVIFNNGGI 480
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6320816   477 YHG-EKDIEG--DLPPTALSKNCRYDLVGKGLGANDFFVNTISELSRCFQQAVQLSRtkreTSVINVIIEP 544
Cdd:PRK09259 481 YRGdDVNLSGagDPSPTVLVHHARYDKMMEAFGGVGYNVTTPDELRHALTEAIASGK----PTLINVVIDP 547
 
Name Accession Description Interval E-value
PRK09259 PRK09259
putative oxalyl-CoA decarboxylase; Validated
13-544 2.49e-125

putative oxalyl-CoA decarboxylase; Validated


Pssm-ID: 236433 [Multi-domain]  Cd Length: 569  Bit Score: 379.33  E-value: 2.49e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    13 LQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSMSNRW 92
Cdd:PRK09259  20 LKLNGIDTIYGVVGIPITDLARLAQAEGIRYIGFRHEQSAGNAAAAAGFLTQKPGVCLTVSAPGFLNGLTALANATTNCF 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    93 PLLVIAGSSSQS--DIHKGGFQELDQVSLLSPFLKFTGK-LTPDNIDMITQKALNYCIQGTAGVSYIDVPADFIEYEKPL 169
Cdd:PRK09259 100 PMIMISGSSEREivDLQQGDYEELDQLNAAKPFCKAAFRvNRAEDIGIGVARAIRTAVSGRPGGVYLDLPAKVLAQTMDA 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   170 EGNDRT----GNELPMILtpnicgPDPSKIKKVVQLILQHKNKniLIVIGKGAV--KNSHEIRRLVNTFNLPFLPTPMAK 243
Cdd:PRK09259 180 DEALTSlvkvVDPAPAQL------PAPEAVDRALDLLKKAKRP--LIILGKGAAyaQADEQIREFVEKTGIPFLPMSMAK 251
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   244 GIVPDSSPLNVSSARSQALKIADIVLVLGARLNWILHFGTSPKWNSESIFIQFDSNPETLgDNNVSPGADLSiwGDIGLS 323
Cdd:PRK09259 252 GLLPDTHPQSAAAARSLALANADVVLLVGARLNWLLSHGKGKTWGADKKFIQIDIEPQEI-DSNRPIAAPVV--GDIGSV 328
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   324 VTALVEELTRQ----DSCWkysgvKQEIREKIQLNQTRLLRKEKTRGAQLNYNQVYGTLRPLIDDYR-TILVTEGANTMD 398
Cdd:PRK09259 329 MQALLAGLKQNtfkaPAEW-----LDALAERKEKNAAKMAEKLSTDTQPMNFYNALGAIRDVLKENPdIYLVNEGANTLD 403
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   399 IARISFPTDAPRRRLDAGTNATMGIGLGYAL--ACKASHPeldVVLIQGDSAFGFSAMEIETAVRCQLALVIVVMNNSGI 476
Cdd:PRK09259 404 LARNIIDMYKPRHRLDCGTWGVMGIGMGYAIaaAVETGKP---VVAIEGDSAFGFSGMEVETICRYNLPVTVVIFNNGGI 480
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6320816   477 YHG-EKDIEG--DLPPTALSKNCRYDLVGKGLGANDFFVNTISELSRCFQQAVQLSRtkreTSVINVIIEP 544
Cdd:PRK09259 481 YRGdDVNLSGagDPSPTVLVHHARYDKMMEAFGGVGYNVTTPDELRHALTEAIASGK----PTLINVVIDP 547
IlvB COG0028
Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme [Amino ...
1-546 9.87e-106

Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439799 [Multi-domain]  Cd Length: 548  Bit Score: 328.27  E-value: 9.87e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    1 MTTTATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVAN-GIKFIPCRNEQAasyaasayGY--ISDKPGVLLIVGGPGL 77
Cdd:COG0028   1 MKMTGADALVEALEAEGVETVFGVPGGAILPLYDALRRQsGIRHILVRHEQGaaf--madGYarATGKPGVCLVTSGPGA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   78 IHALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYI 156
Cdd:COG0028  79 TNLVTGLADAYMDSVPVLAITGQVPTSLIGRGAFQEVDQVGLFRPITKWSYLVTdPEDLPEVLRRAFRIATSGRPGPVVL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  157 DVPADF----IEYEKPlegndrtgnELPMILTPNICGPDPSKIKKVVQLILQHknKNILIVIGKGAVKN--SHEIRRLVN 230
Cdd:COG0028 159 DIPKDVqaaeAEEEPA---------PPELRGYRPRPAPDPEAIEEAAELLAAA--KRPVILAGGGARRAgaAEELRALAE 227
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  231 TFNLPFLPTPMAKGIVPDSSPLNV-------SSARSQALKIADIVLVLGARLNWILHFGTSPkWNSESIFIQFDSNPETL 303
Cdd:COG0028 228 RLGAPVVTTLMGKGAFPEDHPLYLgmlgmhgTPAANEALAEADLVLAVGARFDDRVTGNWDE-FAPDAKIIHIDIDPAEI 306
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  304 GdNNVSPgaDLSIWGDIGLSVTALVEELTRQDScwkysgVKQEIREKIQLNQTRLLRKEKTRGAQLNYNQVYGTLRPLID 383
Cdd:COG0028 307 G-KNYPV--DLPIVGDAKAVLAALLEALEPRAD------DRAAWLARIAAWRAEYLAAYAADDGPIKPQRVIAALREALP 377
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  384 DyRTILVTE-GANTMDIARIsFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRC 462
Cdd:COG0028 378 D-DAIVVTDvGQHQMWAARY-LRFRRPRRFLTSGGLGTMGYGLPAAIGAKLARPDRPVVAITGDGGFQMNLQELATAVRY 455
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  463 QLALVIVVMNNSG---IYHGEKDIEGDLPPTALSKNCRYDLVGKGLGANDFFVNTISELSRCFQQAVQlsrtKRETSVIN 539
Cdd:COG0028 456 GLPVKVVVLNNGGlgmVRQWQELFYGGRYSGTDLPNPDFAKLAEAFGAKGERVETPEELEAALEEALA----SDGPALID 531

                ....*..
gi 6320816  540 VIIEPGE 546
Cdd:COG0028 532 VRVDPEE 538
TPP_BZL_OCoD_HPCL cd02004
Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of ...
371-543 2.14e-74

Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL cleaves the acyloin linkage of benzoin producing 2 molecules of benzaldehyde and enabling the Pseudomonas to grow on benzoin as the sole carbon and energy source. OCoD has a role in the detoxification of oxalate, catalyzing the decarboxylation of oxalyl-CoA to formate. 2-HPCL is a peroxisomal enzyme which plays a role in the alpha-oxidation of 3-methyl-branched fatty acids, catalyzing the cleavage of 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde. All these enzymes depend on Mg2+ and TPP for activity.


Pssm-ID: 238962 [Multi-domain]  Cd Length: 172  Bit Score: 233.96  E-value: 2.14e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  371 YNQVYGTLRPLIDDyRTILVTEGANTMDIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFG 450
Cdd:cd02004   1 PYRVLHELQEALPD-DAIIVSDGGNTMDWARYILRPRKPRHRLDAGTFGTLGVGLGYAIAAALARPDKRVVLVEGDGAFG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  451 FSAMEIETAVRCQLALVIVVMNNSGIYHGEKD----IEGDLPPTALSKNCRYDLVGKGLGANDFFVNTISELSRCFQQAV 526
Cdd:cd02004  80 FSGMELETAVRYNLPIVVVVGNNGGWYQGLDGqqlsYGLGLPVTTLLPDTRYDLVAEAFGGKGELVTTPEELKPALKRAL 159
                       170
                ....*....|....*..
gi 6320816  527 QLSRtkreTSVINVIIE 543
Cdd:cd02004 160 ASGK----PALINVIID 172
acolac_lg TIGR00118
acetolactate synthase, large subunit, biosynthetic type; Two groups of proteins form ...
4-473 3.06e-43

acetolactate synthase, large subunit, biosynthetic type; Two groups of proteins form acetolactate from two molecules of pyruvate. The type of acetolactate synthase described in this model also catalyzes the formation of acetohydroxybutyrate from pyruvate and 2-oxobutyrate, an early step in the branched chain amino acid biosynthesis; it is therefore also termed acetohydroxyacid synthase. In bacteria, this catalytic chain is associated with a smaller regulatory chain in an alpha2/beta2 heterotetramer. Acetolactate synthase is a thiamine pyrophosphate enzyme. In this type, FAD and Mg++ are also found. Several isozymes of this enzyme are found in E. coli K12, one of which contains a frameshift in the large subunit gene and is not expressed. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272915 [Multi-domain]  Cd Length: 558  Bit Score: 162.20  E-value: 3.06e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816      4 TATQHFAQLLQKYGIDTVFGIVGIPIVQLADTM-VANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALA 82
Cdd:TIGR00118   2 SGAEAIIESLKDEGVKTVFGYPGGAILPIYDALyNDSGIEHILVRHEQGAAHAADGYARASGKVGVVLVTSGPGATNLVT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     83 GIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYIDVPAD 161
Cdd:TIGR00118  82 GIATAYMDSIPMVVFTGQVPTSLIGSDAFQEADILGITMPITKHSFQVKsAEDIPRIIKEAFHIATTGRPGPVLVDLPKD 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    162 F----IEYEKPLEGNDRTGNelpmiltPNICGpDPSKIKKVVQLILQHKNKniLIVIGKGAV--KNSHEIRRLVNTFNLP 235
Cdd:TIGR00118 162 VttaeIEYPYPEKVNLPGYR-------PTVKG-HPLQIKKAAELINLAKKP--VILVGGGVIiaGASEELKELAERIQIP 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    236 FLPTPMAKGIVPDSSPLNV-------SSARSQALKIADIVLVLGARL-----NWILHFGTSPKwnsesiFIQFDSNPETL 303
Cdd:TIGR00118 232 VTTTLMGLGSFPEDHPLSLgmlgmhgTKTANLAVHECDLIIAVGARFddrvtGNLAKFAPNAK------IIHIDIDPAEI 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    304 GDNnvsPGADLSIWGD----IGLSVTALVEELTRQDSCWkysgvKQEIREKIQLNQTRLLRKEKTRGAQlnynQVYGTLR 379
Cdd:TIGR00118 306 GKN---VRVDIPIVGDarnvLEELLKKLFELKERKESAW-----LEQINKWKKEYPLKMDYTEEGIKPQ----QVIEELS 373
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    380 PLIDDyRTILVTE-GANTMDIARIsFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIET 458
Cdd:TIGR00118 374 RVTKD-EAIVTTDvGQHQMWAAQF-YPFRKPRRFITSGGLGTMGFGLPAAIGAKVAKPESTVICITGDGSFQMNLQELST 451
                         490
                  ....*....|....*
gi 6320816    459 AVRCQLALVIVVMNN 473
Cdd:TIGR00118 452 AVQYDIPVKILILNN 466
TPP_enzyme_N pfam02776
Thiamine pyrophosphate enzyme, N-terminal TPP binding domain;
5-166 2.22e-37

Thiamine pyrophosphate enzyme, N-terminal TPP binding domain;


Pssm-ID: 460690 [Multi-domain]  Cd Length: 169  Bit Score: 135.83  E-value: 2.22e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816      5 ATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVAN-GIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAG 83
Cdd:pfam02776   1 GAEALADVLKALGVDTVFGVPGGHILPLLDALAKSpGIRYVLTRHEQGAAFAADGYARATGKPGVVLVTSGPGATNALTG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     84 IYNSMSNRWPLLVIAGSSSQSDIHKGGFQ-ELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYIDVPAD 161
Cdd:pfam02776  81 LANAYVDSVPLLVISGQRPRSLVGRGALQqELDQLALFRPVTKWAVRVTsADEIPEVLRRAFRAALSGRPGPVYLEIPLD 160

                  ....*
gi 6320816    162 FIEYE 166
Cdd:pfam02776 161 VLLEE 165
 
Name Accession Description Interval E-value
PRK09259 PRK09259
putative oxalyl-CoA decarboxylase; Validated
13-544 2.49e-125

putative oxalyl-CoA decarboxylase; Validated


Pssm-ID: 236433 [Multi-domain]  Cd Length: 569  Bit Score: 379.33  E-value: 2.49e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    13 LQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSMSNRW 92
Cdd:PRK09259  20 LKLNGIDTIYGVVGIPITDLARLAQAEGIRYIGFRHEQSAGNAAAAAGFLTQKPGVCLTVSAPGFLNGLTALANATTNCF 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    93 PLLVIAGSSSQS--DIHKGGFQELDQVSLLSPFLKFTGK-LTPDNIDMITQKALNYCIQGTAGVSYIDVPADFIEYEKPL 169
Cdd:PRK09259 100 PMIMISGSSEREivDLQQGDYEELDQLNAAKPFCKAAFRvNRAEDIGIGVARAIRTAVSGRPGGVYLDLPAKVLAQTMDA 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   170 EGNDRT----GNELPMILtpnicgPDPSKIKKVVQLILQHKNKniLIVIGKGAV--KNSHEIRRLVNTFNLPFLPTPMAK 243
Cdd:PRK09259 180 DEALTSlvkvVDPAPAQL------PAPEAVDRALDLLKKAKRP--LIILGKGAAyaQADEQIREFVEKTGIPFLPMSMAK 251
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   244 GIVPDSSPLNVSSARSQALKIADIVLVLGARLNWILHFGTSPKWNSESIFIQFDSNPETLgDNNVSPGADLSiwGDIGLS 323
Cdd:PRK09259 252 GLLPDTHPQSAAAARSLALANADVVLLVGARLNWLLSHGKGKTWGADKKFIQIDIEPQEI-DSNRPIAAPVV--GDIGSV 328
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   324 VTALVEELTRQ----DSCWkysgvKQEIREKIQLNQTRLLRKEKTRGAQLNYNQVYGTLRPLIDDYR-TILVTEGANTMD 398
Cdd:PRK09259 329 MQALLAGLKQNtfkaPAEW-----LDALAERKEKNAAKMAEKLSTDTQPMNFYNALGAIRDVLKENPdIYLVNEGANTLD 403
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   399 IARISFPTDAPRRRLDAGTNATMGIGLGYAL--ACKASHPeldVVLIQGDSAFGFSAMEIETAVRCQLALVIVVMNNSGI 476
Cdd:PRK09259 404 LARNIIDMYKPRHRLDCGTWGVMGIGMGYAIaaAVETGKP---VVAIEGDSAFGFSGMEVETICRYNLPVTVVIFNNGGI 480
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6320816   477 YHG-EKDIEG--DLPPTALSKNCRYDLVGKGLGANDFFVNTISELSRCFQQAVQLSRtkreTSVINVIIEP 544
Cdd:PRK09259 481 YRGdDVNLSGagDPSPTVLVHHARYDKMMEAFGGVGYNVTTPDELRHALTEAIASGK----PTLINVVIDP 547
IlvB COG0028
Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme [Amino ...
1-546 9.87e-106

Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Acetolactate synthase large subunit or other thiamine pyrophosphate-requiring enzyme is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 439799 [Multi-domain]  Cd Length: 548  Bit Score: 328.27  E-value: 9.87e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    1 MTTTATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVAN-GIKFIPCRNEQAasyaasayGY--ISDKPGVLLIVGGPGL 77
Cdd:COG0028   1 MKMTGADALVEALEAEGVETVFGVPGGAILPLYDALRRQsGIRHILVRHEQGaaf--madGYarATGKPGVCLVTSGPGA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   78 IHALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYI 156
Cdd:COG0028  79 TNLVTGLADAYMDSVPVLAITGQVPTSLIGRGAFQEVDQVGLFRPITKWSYLVTdPEDLPEVLRRAFRIATSGRPGPVVL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  157 DVPADF----IEYEKPlegndrtgnELPMILTPNICGPDPSKIKKVVQLILQHknKNILIVIGKGAVKN--SHEIRRLVN 230
Cdd:COG0028 159 DIPKDVqaaeAEEEPA---------PPELRGYRPRPAPDPEAIEEAAELLAAA--KRPVILAGGGARRAgaAEELRALAE 227
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  231 TFNLPFLPTPMAKGIVPDSSPLNV-------SSARSQALKIADIVLVLGARLNWILHFGTSPkWNSESIFIQFDSNPETL 303
Cdd:COG0028 228 RLGAPVVTTLMGKGAFPEDHPLYLgmlgmhgTPAANEALAEADLVLAVGARFDDRVTGNWDE-FAPDAKIIHIDIDPAEI 306
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  304 GdNNVSPgaDLSIWGDIGLSVTALVEELTRQDScwkysgVKQEIREKIQLNQTRLLRKEKTRGAQLNYNQVYGTLRPLID 383
Cdd:COG0028 307 G-KNYPV--DLPIVGDAKAVLAALLEALEPRAD------DRAAWLARIAAWRAEYLAAYAADDGPIKPQRVIAALREALP 377
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  384 DyRTILVTE-GANTMDIARIsFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRC 462
Cdd:COG0028 378 D-DAIVVTDvGQHQMWAARY-LRFRRPRRFLTSGGLGTMGYGLPAAIGAKLARPDRPVVAITGDGGFQMNLQELATAVRY 455
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  463 QLALVIVVMNNSG---IYHGEKDIEGDLPPTALSKNCRYDLVGKGLGANDFFVNTISELSRCFQQAVQlsrtKRETSVIN 539
Cdd:COG0028 456 GLPVKVVVLNNGGlgmVRQWQELFYGGRYSGTDLPNPDFAKLAEAFGAKGERVETPEELEAALEEALA----SDGPALID 531

                ....*..
gi 6320816  540 VIIEPGE 546
Cdd:COG0028 532 VRVDPEE 538
TPP_BZL_OCoD_HPCL cd02004
Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of ...
371-543 2.14e-74

Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL cleaves the acyloin linkage of benzoin producing 2 molecules of benzaldehyde and enabling the Pseudomonas to grow on benzoin as the sole carbon and energy source. OCoD has a role in the detoxification of oxalate, catalyzing the decarboxylation of oxalyl-CoA to formate. 2-HPCL is a peroxisomal enzyme which plays a role in the alpha-oxidation of 3-methyl-branched fatty acids, catalyzing the cleavage of 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde. All these enzymes depend on Mg2+ and TPP for activity.


Pssm-ID: 238962 [Multi-domain]  Cd Length: 172  Bit Score: 233.96  E-value: 2.14e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  371 YNQVYGTLRPLIDDyRTILVTEGANTMDIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFG 450
Cdd:cd02004   1 PYRVLHELQEALPD-DAIIVSDGGNTMDWARYILRPRKPRHRLDAGTFGTLGVGLGYAIAAALARPDKRVVLVEGDGAFG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  451 FSAMEIETAVRCQLALVIVVMNNSGIYHGEKD----IEGDLPPTALSKNCRYDLVGKGLGANDFFVNTISELSRCFQQAV 526
Cdd:cd02004  80 FSGMELETAVRYNLPIVVVVGNNGGWYQGLDGqqlsYGLGLPVTTLLPDTRYDLVAEAFGGKGELVTTPEELKPALKRAL 159
                       170
                ....*....|....*..
gi 6320816  527 QLSRtkreTSVINVIIE 543
Cdd:cd02004 160 ASGK----PALINVIID 172
PRK05858 PRK05858
acetolactate synthase;
5-544 1.27e-60

acetolactate synthase;


Pssm-ID: 235629 [Multi-domain]  Cd Length: 542  Bit Score: 209.58  E-value: 1.27e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     5 ATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGI 84
Cdd:PRK05858   7 AGRLAARRLKAHGVDTMFTLSGGHLFPLYDGAREEGIRLIDVRHEQTAAFAAEAWAKLTRVPGVAVLTAGPGVTNGMSAM 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    85 YNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKF--TGkLTPDNIDMITQKALNYCIQGTAGVSYIDVPADf 162
Cdd:PRK05858  87 AAAQFNQSPLVVLGGRAPALRWGMGSLQEIDHVPFVAPVTKFaaTA-QSAENAGRLVDQALQAAVTPHRGPVFVDFPMD- 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   163 iEYEKPLEGNDRTGnelPMILTPNICGPDPSKIKKVVQLILQHKNKniLIVIGKGAVKNSHE--IRRLVNTFNLPFLPTP 240
Cdd:PRK05858 165 -HAFSMADDDGRPG---ALTELPAGPTPDPDALARAAGLLAEAQRP--VIMAGTDVWWGHAEaaLLRLAEELGIPVLMNG 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   241 MAKGIVPDSSPLNVSSARSQALKIADIVLVLGARLNWILHFGTspkWNSESIFIQFDSNPETLgDNNVSPGADLSiwGDI 320
Cdd:PRK05858 239 MGRGVVPADHPLAFSRARGKALGEADVVLVVGVPMDFRLGFGV---FGGTAQLVHVDDAPPQR-AHHRPVAAGLY--GDL 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   321 GLSVTALVEEltrqdscWKYSGVKQEIREKIQLNQTRLLRKEKTRGAQ----LNYNQVYGTLRPLIDDyRTILVTEGANT 396
Cdd:PRK05858 313 SAILSALAGA-------GGDRTDHQGWIEELRTAETAARARDAAELADdrdpIHPMRVYGELAPLLDR-DAIVIGDGGDF 384
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   397 MDIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVIVVMNNsGI 476
Cdd:PRK05858 385 VSYAGRYIDPYRPGCWLDPGPFGCLGTGPGYALAARLARPSRQVVLLQGDGAFGFSLMDVDTLVRHNLPVVSVIGNN-GI 463
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   477 YHGEK---------DIEGDLPPtalskNCRYDLVGKGLGANDFFVNTISE----LSRCFQQAVqlsrtkreTSVINVIIE 543
Cdd:PRK05858 464 WGLEKhpmealygyDVAADLRP-----GTRYDEVVRALGGHGELVTVPAElgpaLERAFASGV--------PYLVNVLTD 530

                 .
gi 6320816   544 P 544
Cdd:PRK05858 531 P 531
PRK08266 PRK08266
hypothetical protein; Provisional
1-474 1.16e-45

hypothetical protein; Provisional


Pssm-ID: 181337 [Multi-domain]  Cd Length: 542  Bit Score: 168.65  E-value: 1.16e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     1 MTTTATQHFAQLLQKYGIDTVFGIVGIPIVQLADTM--VANGIKFIPCRNEQAASYAASayGY--ISDKPGVLLIVGGPG 76
Cdd:PRK08266   2 TTMTGGEAIVAGLVAHGVDTVFGLPGAQLYWLFDALykAGDRIRVIHTRHEQAAGYMAF--GYarSTGRPGVCSVVPGPG 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    77 LIHALAGIYNSMSNRWPLLVIAGSSSQSDIHKG-GF-QEL-DQVSLLSPFLKFTGK-LTPDNIDMITQKALNYCIQGTAG 152
Cdd:PRK08266  80 VLNAGAALLTAYGCNSPVLCLTGQIPSALIGKGrGHlHEMpDQLATLRSFTKWAERiEHPSEAPALVAEAFQQMLSGRPR 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   153 VSYIDVPADFIEyekplegndRTGNELPMILTPNICGP--DPSKIKKVVQLILQHKNKniLIVIGKGAVKNSHEIRRLVN 230
Cdd:PRK08266 160 PVALEMPWDVFG---------QRAPVAAAPPLRPAPPPapDPDAIAAAAALIAAAKNP--MIFVGGGAAGAGEEIRELAE 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   231 TFNLPFLPTPMAKGIVPDSSPLNVSSARSQAL-KIADIVLVLGARLnwILHFGTSPKWNSESIFIQFDSNPETlgdnNVS 309
Cdd:PRK08266 229 MLQAPVVAFRSGRGIVSDRHPLGLNFAAAYELwPQTDVVIGIGSRL--ELPTFRWPWRPDGLKVIRIDIDPTE----MRR 302
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   310 PGADLSIWGDIGLSVTALVEELTRQDScwKYSGVKQEIREKIQLNQTRLLRKEktrgAQLNYNQVygtLRP-LIDDyrTI 388
Cdd:PRK08266 303 LKPDVAIVADAKAGTAALLDALSKAGS--KRPSRRAELRELKAAARQRIQAVQ----PQASYLRA---IREaLPDD--GI 371
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   389 LVTEGANTMDIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVI 468
Cdd:PRK08266 372 FVDELSQVGFASWFAFPVYAPRTFVTCGYQGTLGYGFPTALGAKVANPDRPVVSITGDGGFMFGVQELATAVQHNIGVVT 451

                 ....*.
gi 6320816   469 VVMNNS 474
Cdd:PRK08266 452 VVFNNN 457
PRK08611 PRK08611
pyruvate oxidase; Provisional
1-546 5.64e-45

pyruvate oxidase; Provisional


Pssm-ID: 181502 [Multi-domain]  Cd Length: 576  Bit Score: 167.49  E-value: 5.64e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     1 MTTTATQHFAQLLQKYGIDTVFGIVGIPIVQLADTM--VANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLI 78
Cdd:PRK08611   2 AKIKAGEALVKLLQDWGIDHVYGIPGDSIDAVVDALrkEQDKIKFIQVRHEEVAALAAAAYAKLTGKIGVCLSIGGPGAI 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    79 HALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKL-TPDNIDMITQKALNyciqgTA----GV 153
Cdd:PRK08611  82 HLLNGLYDAKMDHVPVLALAGQVTSDLLGTDFFQEVNLEKMFEDVAVYNHQImSAENLPEIVNQAIR-----TAyekkGV 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   154 SYIDVPADFieyekPLEGNDRTGNELPMILTPNICGPDPSKIKKVVQLIlqHKNKNILIVIGKGAVKNSHEIRRLVNTFN 233
Cdd:PRK08611 157 AVLTIPDDL-----PAQKIKDTTNKTVDTFRPTVPSPKPKDIKKAAKLI--NKAKKPVILAGLGAKHAKEELLAFAEKAK 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   234 LPFLPTPMAKGIVPDSSPLNV-------SSARSQALKIADIVLVLgarlnwilhfGTS-------PKwnsESIFIQFDSN 299
Cdd:PRK08611 230 IPIIHTLPAKGIIPDDHPYSLgnlgkigTKPAYEAMQEADLLIMV----------GTNypyvdylPK---KAKAIQIDTD 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   300 PETLGDN-NVSPGadlsIWGDIGLSVTALVEELTRQD------SCWKYSGVKQEIREKIQLNQTRLLRKEktrgaqlnyn 372
Cdd:PRK08611 297 PANIGKRyPVNVG----LVGDAKKALHQLTENIKHVEdrrfleACQENMAKWWKWMEEDENNASTPIKPE---------- 362
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   373 QVYGTLRPLIDDYRTILVTEGANTMDIArisfptdaprRRLDAGTN---------ATMGIGLGYALACKASHPELDVVLI 443
Cdd:PRK08611 363 RVMAAIQKIADDDAVLSVDVGTVTVWSA----------RYLNLGTNqkfiisswlGTMGCGLPGAIAAKIAFPDRQAIAI 432
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   444 QGDSAFGFSAMEIETAVRCQLALVIVVMNNSGI----YH----GEKDIEGDLPPTALSK---NCRydlvGKGlgandFFV 512
Cdd:PRK08611 433 CGDGGFSMVMQDFVTAVKYKLPIVVVVLNNQQLafikYEqqaaGELEYAIDLSDMDYAKfaeACG----GKG-----YRV 503
                        570       580       590
                 ....*....|....*....|....*....|....
gi 6320816   513 NTISELSRCFQQAVQLSRtkreTSVINVIIEPGE 546
Cdd:PRK08611 504 EKAEELDPAFEEALAQDK----PVIIDVYVDPNA 533
PRK08617 PRK08617
acetolactate synthase AlsS;
3-475 3.19e-44

acetolactate synthase AlsS;


Pssm-ID: 236312 [Multi-domain]  Cd Length: 552  Bit Score: 165.03  E-value: 3.19e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     3 TTATQHFAQL----LQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLI 78
Cdd:PRK08617   1 TDKKKYGADLvvdsLINQGVKYVFGIPGAKIDRVFDALEDSGPELIVTRHEQNAAFMAAAIGRLTGKPGVVLVTSGPGVS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    79 HALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYID 157
Cdd:PRK08617  81 NLATGLVTATAEGDPVVAIGGQVKRADRLKRTHQSMDNVALFRPITKYSAEVQdPDNLSEVLANAFRAAESGRPGAAFVS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   158 VPADFIeyEKPLegndrTGNELPMILTPNICGPDPSKIKKVVQLILQHKNKNILIVIGKGAVKNSHEIRRLVNTFNLPFL 237
Cdd:PRK08617 161 LPQDVV--DAPV-----TSKAIAPLSKPKLGPASPEDINYLAELIKNAKLPVLLLGMRASSPEVTAAIRRLLERTNLPVV 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   238 PTPMAKGIVpdSSPL------NVSSARSQA----LKIADIVLVLG-------ARLnwilhfgtspkWNSE--SIFIQFDS 298
Cdd:PRK08617 234 ETFQAAGVI--SRELedhffgRVGLFRNQPgdelLKKADLVITIGydpieyePRN-----------WNSEgdATIIHIDV 300
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   299 NPETLgDNNVSPgaDLSIWGDIGLSVTALVEELTRqdscWKYSGVKQEIREKIQlnqtRLLRKEKTRGAQLNYN-----Q 373
Cdd:PRK08617 301 LPAEI-DNYYQP--ERELIGDIAATLDLLAEKLDG----LSLSPQSLEILEELR----AQLEELAERPARLEEGavhplR 369
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   374 VYGTLRPLIDDYRTILVTEGANTMDIARiSFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSA 453
Cdd:PRK08617 370 IIRALQDIVTDDTTVTVDVGSHYIWMAR-YFRSYEPRHLLFSNGMQTLGVALPWAIAAALVRPGKKVVSVSGDGGFLFSA 448
                        490       500
                 ....*....|....*....|..
gi 6320816   454 MEIETAVRCQLALVIVVMNNSG 475
Cdd:PRK08617 449 MELETAVRLKLNIVHIIWNDGH 470
PRK08322 PRK08322
acetolactate synthase large subunit;
4-475 5.06e-44

acetolactate synthase large subunit;


Pssm-ID: 236239 [Multi-domain]  Cd Length: 547  Bit Score: 164.23  E-value: 5.06e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     4 TATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAG 83
Cdd:PRK08322   2 KAADLFVKCLENEGVEYIFGIPGEENLDLLEALRDSSIKLILTRHEQGAAFMAATYGRLTGKAGVCLSTLGPGATNLVTG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    84 IYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGK-LTPDNIDMITQKALNYCIQGTAGVSYIDVPADF 162
Cdd:PRK08322  82 VAYAQLGGMPMVAITGQKPIKRSKQGSFQIVDVVAMMAPLTKWTRQiVSPDNIPEVVREAFRLAEEERPGAVHLELPEDI 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   163 IEYE---KPLEgndRTGNELPMiltpnicgPDPSKIKKVVQLIlqHKNKNILIVIGKGAVKN--SHEIRRLVNTFNLPFL 237
Cdd:PRK08322 162 AAEEtdgKPLP---RSYSRRPY--------ASPKAIERAAEAI--QAAKNPLILIGAGANRKtaSKALTEFVDKTGIPFF 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   238 PTPMAKGIVPDSSPLNVSSARSQ-------ALKIADIVLVLGARLnwiLHFgtSP-KWNSES----IFIQFDSNPEtlgD 305
Cdd:PRK08322 229 TTQMGKGVIPETHPLSLGTAGLSqgdyvhcAIEHADLIINVGHDV---IEK--PPfFMNPNGdkkvIHINFLPAEV---D 300
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   306 NNVSPgaDLSIWGDIGLSVTALVEELTRQDScWKYSGVKqEIREKIqlnqtrllRKEKTRGAQLNYNQVYgtlrP--LID 383
Cdd:PRK08322 301 PVYFP--QVEVVGDIANSLWQLKERLADQPH-WDFPRFL-KIREAI--------EAHLEEGADDDRFPMK----PqrIVA 364
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   384 DYRT-------ILVTEGANTMDIARiSFPTDAPRRRL-DAGTnATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAME 455
Cdd:PRK08322 365 DLRKvmpdddiVILDNGAYKIWFAR-NYRAYEPNTCLlDNAL-ATMGAGLPSAIAAKLVHPDRKVLAVCGDGGFMMNSQE 442
                        490       500
                 ....*....|....*....|
gi 6320816   456 IETAVRCQLALVIVVMNNSG 475
Cdd:PRK08322 443 LETAVRLGLPLVVLILNDNA 462
acolac_lg TIGR00118
acetolactate synthase, large subunit, biosynthetic type; Two groups of proteins form ...
4-473 3.06e-43

acetolactate synthase, large subunit, biosynthetic type; Two groups of proteins form acetolactate from two molecules of pyruvate. The type of acetolactate synthase described in this model also catalyzes the formation of acetohydroxybutyrate from pyruvate and 2-oxobutyrate, an early step in the branched chain amino acid biosynthesis; it is therefore also termed acetohydroxyacid synthase. In bacteria, this catalytic chain is associated with a smaller regulatory chain in an alpha2/beta2 heterotetramer. Acetolactate synthase is a thiamine pyrophosphate enzyme. In this type, FAD and Mg++ are also found. Several isozymes of this enzyme are found in E. coli K12, one of which contains a frameshift in the large subunit gene and is not expressed. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272915 [Multi-domain]  Cd Length: 558  Bit Score: 162.20  E-value: 3.06e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816      4 TATQHFAQLLQKYGIDTVFGIVGIPIVQLADTM-VANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALA 82
Cdd:TIGR00118   2 SGAEAIIESLKDEGVKTVFGYPGGAILPIYDALyNDSGIEHILVRHEQGAAHAADGYARASGKVGVVLVTSGPGATNLVT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     83 GIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYIDVPAD 161
Cdd:TIGR00118  82 GIATAYMDSIPMVVFTGQVPTSLIGSDAFQEADILGITMPITKHSFQVKsAEDIPRIIKEAFHIATTGRPGPVLVDLPKD 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    162 F----IEYEKPLEGNDRTGNelpmiltPNICGpDPSKIKKVVQLILQHKNKniLIVIGKGAV--KNSHEIRRLVNTFNLP 235
Cdd:TIGR00118 162 VttaeIEYPYPEKVNLPGYR-------PTVKG-HPLQIKKAAELINLAKKP--VILVGGGVIiaGASEELKELAERIQIP 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    236 FLPTPMAKGIVPDSSPLNV-------SSARSQALKIADIVLVLGARL-----NWILHFGTSPKwnsesiFIQFDSNPETL 303
Cdd:TIGR00118 232 VTTTLMGLGSFPEDHPLSLgmlgmhgTKTANLAVHECDLIIAVGARFddrvtGNLAKFAPNAK------IIHIDIDPAEI 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    304 GDNnvsPGADLSIWGD----IGLSVTALVEELTRQDSCWkysgvKQEIREKIQLNQTRLLRKEKTRGAQlnynQVYGTLR 379
Cdd:TIGR00118 306 GKN---VRVDIPIVGDarnvLEELLKKLFELKERKESAW-----LEQINKWKKEYPLKMDYTEEGIKPQ----QVIEELS 373
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    380 PLIDDyRTILVTE-GANTMDIARIsFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIET 458
Cdd:TIGR00118 374 RVTKD-EAIVTTDvGQHQMWAAQF-YPFRKPRRFITSGGLGTMGFGLPAAIGAKVAKPESTVICITGDGSFQMNLQELST 451
                         490
                  ....*....|....*
gi 6320816    459 AVRCQLALVIVVMNN 473
Cdd:TIGR00118 452 AVQYDIPVKILILNN 466
sulphoacet_xsc TIGR03457
sulfoacetaldehyde acetyltransferase; Members of this protein family are sulfoacetaldehyde ...
4-542 2.67e-42

sulfoacetaldehyde acetyltransferase; Members of this protein family are sulfoacetaldehyde acetyltransferase, an enzyme of taurine utilization. Taurine, or 2-aminoethanesulfonate, can be used by bacteria as a source of carbon, nitrogen, and sulfur. [Central intermediary metabolism, Other]


Pssm-ID: 132497 [Multi-domain]  Cd Length: 579  Bit Score: 160.03  E-value: 2.67e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816      4 TATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAG 83
Cdd:TIGR03457   3 TPSEAFVEVLVANGVTHAFGIMGSAFMDAMDLFPPAGIRFIPVVHEQGAGHMADGFARVTGRMSMVIGQNGPGVTNCVTA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     84 IYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTaGVSYIDVPADF 162
Cdd:TIGR03457  83 IAAAYWAHTPVVIVTPEAGTKTIGLGGFQEADQLPMFQEFTKYQGHVRhPSRMAEVLNRCFERAWREM-GPAQLNIPRDY 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    163 IeYEKPLEgndrtgnELPMIlTPNICGP-DPSKIKKVVQLILQHKNKniLIVIGKGAVKNS--HEIRRLVNTFNLPFLPT 239
Cdd:TIGR03457 162 F-YGEIDV-------EIPRP-VRLDRGAgGATSLAQAARLLAEAKFP--VIISGGGVVMGDavEECKALAERLGAPVVNS 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    240 PMAKGIVPDSSPLNV-------SSARSQALKIADIVLVLGARLNwilHFGTSPK-----WNSESIFIQFDSNPETLG-DN 306
Cdd:TIGR03457 231 YLHNDSFPASHPLWVgplgyqgSKAAMKLISDADVVLALGTRLG---PFGTLPQygidyWPKNAKIIQVDANAKMIGlVK 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    307 NVSPGadlsIWGDIGLSVTALVEELTRqdscwKYSGVKQEIR-EKIQLNQTRLLRK-------------------EKTRG 366
Cdd:TIGR03457 308 KVTVG----ICGDAKAAAAEILQRLAG-----KAGDANRAERkAKIQAERSAWEQElsemtherdpfsldmiveqRQEEG 378
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    367 AQLNYNQVYGTLRPLIDDyRTILVTEGANTMDIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGD 446
Cdd:TIGR03457 379 NWLHPRQVLRELEKAMPE-DAIVSTDIGNINSVANSYLRFEKPRKFLAPMSFGNCGYAFPTIIGAKIAAPDRPVVAYAGD 457
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    447 SAFGFSAMEIETAVRCQLALVIVVMNNSGiYHGEKDIEGD-----LPPTALSKNCRYDLVGKGLGANDFFVNTISELSRC 521
Cdd:TIGR03457 458 GAWGMSMNEIMTAVRHDIPVTAVVFRNRQ-WGAEKKNQVDfynnrFVGTELESELSFAGIADAMGAKGVVVDKPEDVGPA 536
                         570       580
                  ....*....|....*....|.
gi 6320816    522 FQQAVQlSRTKRETSVINVII 542
Cdd:TIGR03457 537 LKKAIA-AQAEGKTTVIEIVC 556
PRK07525 PRK07525
sulfoacetaldehyde acetyltransferase; Validated
1-542 2.72e-39

sulfoacetaldehyde acetyltransferase; Validated


Pssm-ID: 236042 [Multi-domain]  Cd Length: 588  Bit Score: 151.30  E-value: 2.72e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     1 MTTTATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHA 80
Cdd:PRK07525   4 MKMTPSEAFVETLQAHGITHAFGIIGSAFMDASDLFPPAGIRFIDVAHEQNAGHMADGYTRVTGRMGMVIGQNGPGITNF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    81 LAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSyIDVP 159
Cdd:PRK07525  84 VTAVATAYWAHTPVVLVTPQAGTKTIGQGGFQEAEQMPMFEDMTKYQEEVRdPSRMAEVLNRVFDKAKRESGPAQ-INIP 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   160 ADFIeyekplegndrTG---NELPMILTPNICGPDPSKIKKVVQLILQHKNKNIL----IVIGkGAVKnshEIRRLVNTF 232
Cdd:PRK07525 163 RDYF-----------YGvidVEIPQPVRLERGAGGEQSLAEAAELLSEAKFPVILsgagVVLS-DAIE---ECKALAERL 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   233 NLPFLPTPMAKGIVPDSSPL-------NVSSARSQALKIADIVLVLGARLNwilHFGTSPK-----WNSESIFIQFDSNP 300
Cdd:PRK07525 228 DAPVACGYLHNDAFPGSHPLwvgplgyNGSKAAMELIAKADVVLALGTRLN---PFGTLPQygidyWPKDAKIIQVDINP 304
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   301 ETLGdnnVSPGADLSIWGDIGLSVTALVEELTRQDSCwkySGVKQEIREKIQLNQTR----------------LLRKEKT 364
Cdd:PRK07525 305 DRIG---LTKKVSVGICGDAKAVARELLARLAERLAG---DAGREERKALIAAEKSAweqelsswdhedddpgTDWNEEA 378
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   365 RGAQLNY---NQVYGTLRPLIDDyRTILVTEGANTMDIARiSFPT-DAPRRRLDAGTNATMGIGLGYALACKASHPELDV 440
Cdd:PRK07525 379 RARKPDYmhpRQALREIQKALPE-DAIVSTDIGNNCSIAN-SYLRfEKGRKYLAPGSFGNCGYAFPAIIGAKIACPDRPV 456
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   441 VLIQGDSAFGFSAMEIETAVRCQLALVIVVMNNsGIYHGEKD----------IEGDLPPtalskNCRYDLVGKGLGANDF 510
Cdd:PRK07525 457 VGFAGDGAWGISMNEVMTAVRHNWPVTAVVFRN-YQWGAEKKnqvdfynnrfVGTELDN-----NVSYAGIAEAMGAEGV 530
                        570       580       590
                 ....*....|....*....|....*....|..
gi 6320816   511 FVNTISELSRCFQQAVQlSRTKRETSVINVII 542
Cdd:PRK07525 531 VVDTQEELGPALKRAID-AQNEGKTTVIEIMC 561
TPP_PYR_POX_like cd07035
Pyrimidine (PYR) binding domain of POX and related proteins; Thiamine pyrophosphate (TPP ...
7-160 3.58e-39

Pyrimidine (PYR) binding domain of POX and related proteins; Thiamine pyrophosphate (TPP family), pyrimidine (PYR) binding domain of pyruvate oxidase (POX) and related protiens subfamily. The PYR domain is found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. TPP binds in the cleft formed by a PYR domain and a PP domain. The PYR domain, binds the aminopyrimidine ring of TPP, the PP domain binds the diphosphate residue. A polar interaction between the conserved glutamate of the PYR domain and the N1' of the TPP aminopyrimidine ring is shared by most TPP-dependent enzymes, and participates in the activation of TPP. For glyoxylate carboligase, which belongs to this subfamily, but lacks this conserved glutamate, the rate of the initial TPP activation step is reduced but the ensuing steps of the enzymic reaction proceed efficiently. The PYR and PP domains have a common fold, but do not share strong sequence conservation. The PP domain is not included in this sub-family. Most TPP-dependent enzymes have the PYR and PP domains on the same subunit although these domains can be alternatively arranged in the primary structure. TPP-dependent enzymes are multisubunit proteins, the smallest catalytic unit being a dimer-of-active sites, for many the active sites lie between PP and PYR domains on different subunits. POX decarboxylates pyruvate, producing hydrogen peroxide and the energy-storage metabolite acetylphosphate. This subfamily includes pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC catalyzes the conversion of pyruvate to acetaldehyde and CO2 in alcoholic fermentation. IPDC plays a role in the indole-3-pyruvic acid (IPA) pathway in plants and various plant-associated bacteria, it catalyzes the decarboxylation of IPA to IAA. This subfamily also includes the large catalytic subunit of acetohydroxyacid synthase (AHAS). AHAS catalyzes the condensation of two molecules of pyruvate to give the acetohydroxyacid, 2-acetolactate, a precursor of the branched chain amino acids, valine and leucine. AHAS also catalyzes the condensation of pyruvate and 2-ketobutyrate to form 2-aceto-2-hydroxybutyrate in isoleucine biosynthesis. Methanococcus jannaschii sulfopyruvate decarboxylase (MjComDE) and phosphonopyruvate decarboxylase (PpyrDc) also belong to this subfamily. PpyrDc is a homotrimeric enzyme having the PP and PYR domains tandemly arranged on the same subunit. It functions in the biosynthesis of C-P compounds such as bialaphos tripeptide in Streptomyces hygroscopicus. MjComDE is a dodecamer having the PYR and PP domains on different subunits, it has six alpha (PYR/ComD) subunits and six beta (PP/ComE) subunits. MjComDE catalyzes the decarboxylation of sulfopyruvic acid to sulfoacetaldehyde in the coenzyme M pathway.


Pssm-ID: 132918 [Multi-domain]  Cd Length: 155  Bit Score: 140.36  E-value: 3.58e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    7 QHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYN 86
Cdd:cd07035   1 DALVEALKAEGVDHVFGVPGGAILPLLDALARSGIRYILVRHEQGAVGMADGYARATGKPGVVLVTSGPGLTNAVTGLAN 80
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6320816   87 SMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYIDVPA 160
Cdd:cd07035  81 AYLDSIPLLVITGQRPTAGEGRGAFQEIDQVALFRPITKWAYRVTsPEEIPEALRRAFRIALSGRPGPVALDLPK 155
PRK06725 PRK06725
acetolactate synthase large subunit;
4-473 1.27e-38

acetolactate synthase large subunit;


Pssm-ID: 180672 [Multi-domain]  Cd Length: 570  Bit Score: 149.35  E-value: 1.27e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     4 TATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAG 83
Cdd:PRK06725  16 TGAGHVIQCLKKLGVTTVFGYPGGAILPVYDALYESGLKHILTRHEQAAIHAAEGYARASGKVGVVFATSGPGATNLVTG 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    84 IYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLTPDN-IDMITQKALNYCIQGTAGVSYIDVPADF 162
Cdd:PRK06725  96 LADAYMDSIPLVVITGQVATPLIGKDGFQEADVVGITVPVTKHNYQVRDVNqLSRIVQEAFYIAESGRPGPVLIDIPKDV 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   163 IEYEKPLEGNDRTgnELP-MILTPNicgPDPSKIKKVVQLIlqHKNKNILIVIGKGAVKN--SHEIRRLVNTFNLPFLPT 239
Cdd:PRK06725 176 QNEKVTSFYNEVV--EIPgYKPEPR---PDSMKLREVAKAI--SKAKRPLLYIGGGVIHSggSEELIEFARENRIPVVST 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   240 PMAKGIVPDSSPLNV-------SSARSQALKIADIVLVLGARLNWILHfGTSPKWNSESIFIQFDSNPETLGDNnvsPGA 312
Cdd:PRK06725 249 LMGLGAYPPGDPLFLgmlgmhgTYAANMAVTECDLLLALGVRFDDRVT-GKLELFSPHSKKVHIDIDPSEFHKN---VAV 324
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   313 DLSIWGDIGLSVTALVEE-LTRQDSCWkysgvkqeirekiqLNQTRLLRKEktrgAQLNYNQVYGTLRP-----LIDDY- 385
Cdd:PRK06725 325 EYPVVGDVKKALHMLLHMsIHTQTDEW--------------LQKVKTWKEE----YPLSYKQKESELKPqhvinLVSELt 386
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   386 --RTILVTEGANTMDIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQ 463
Cdd:PRK06725 387 ngEAIVTTEVGQHQMWAAHFYKAKNPRTFLTSGGLGTMGFGFPAAIGAQLAKEEELVICIAGDASFQMNIQELQTIAENN 466
                        490
                 ....*....|
gi 6320816   464 LALVIVVMNN 473
Cdd:PRK06725 467 IPVKVFIINN 476
PRK06276 PRK06276
acetolactate synthase large subunit;
13-546 7.41e-38

acetolactate synthase large subunit;


Pssm-ID: 235766 [Multi-domain]  Cd Length: 586  Bit Score: 147.21  E-value: 7.41e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    13 LQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSMSNRW 92
Cdd:PRK06276  11 LEAEGVKIIFGYPGGALLPFYDALYDSDLIHILTRHEQAAAHAADGYARASGKVGVCVATSGPGATNLVTGIATAYADSS 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    93 PLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYIDVPADFIEYEKPLEG 171
Cdd:PRK06276  91 PVIALTGQVPTKLIGNDAFQEIDALGIFMPITKHNFQIKkPEEIPEIFRAAFEIAKTGRPGPVHIDLPKDVQEGELDLEK 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   172 NDRTGN-ELPMiLTPNICGpDPSKIKKVVQLILQHKNKNILI---VIGKGAvknSHEIRRLVNTFNLPFLPTPMAKGIVP 247
Cdd:PRK06276 171 YPIPAKiDLPG-YKPTTFG-HPLQIKKAAELIAEAERPVILAgggVIISGA---SEELIELSELVKIPVCTTLMGKGAFP 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   248 DSSPLNV-------SSARSQALKIADIVLVLGARLN-----WILHFGTSPKwnsesiFIQFDSNPETLGDNnvsPGADLS 315
Cdd:PRK06276 246 EDHPLALgmvgmhgTKAANYSVTESDVLIAIGCRFSdrttgDISSFAPNAK------IIHIDIDPAEIGKN---VRVDVP 316
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   316 IWGDIGLSVTALVEELTRqdscwKYSGVKQEIREKIQLNQT----RLLRKEKTRGAQLNYNQVYGTLRPLIDDYRTILVT 391
Cdd:PRK06276 317 IVGDAKNVLRDLLAELMK-----KEIKNKSEWLERVKKLKKesipRMDFDDKPIKPQRVIKELMEVLREIDPSKNTIITT 391
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   392 E-GANTMDIARIsFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVIVV 470
Cdd:PRK06276 392 DvGQNQMWMAHF-FKTSAPRSFISSGGLGTMGFGFPAAIGAKVAKPDANVIAITGDGGFLMNSQELATIAEYDIPVVICI 470
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   471 MNN---------SGIYHGEKDIEGDLPPTAlskncryDLV--GKGLGANDFFVNTISELSRCFQQAVQlsrtKRETSVIN 539
Cdd:PRK06276 471 FDNrtlgmvyqwQNLYYGKRQSEVHLGETP-------DFVklAESYGVKADRVEKPDEIKEALKEAIK----SGEPYLLD 539

                 ....*..
gi 6320816   540 VIIEPGE 546
Cdd:PRK06276 540 IIIDPAE 546
TPP_enzyme_N pfam02776
Thiamine pyrophosphate enzyme, N-terminal TPP binding domain;
5-166 2.22e-37

Thiamine pyrophosphate enzyme, N-terminal TPP binding domain;


Pssm-ID: 460690 [Multi-domain]  Cd Length: 169  Bit Score: 135.83  E-value: 2.22e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816      5 ATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVAN-GIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAG 83
Cdd:pfam02776   1 GAEALADVLKALGVDTVFGVPGGHILPLLDALAKSpGIRYVLTRHEQGAAFAADGYARATGKPGVVLVTSGPGATNALTG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     84 IYNSMSNRWPLLVIAGSSSQSDIHKGGFQ-ELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYIDVPAD 161
Cdd:pfam02776  81 LANAYVDSVPLLVISGQRPRSLVGRGALQqELDQLALFRPVTKWAVRVTsADEIPEVLRRAFRAALSGRPGPVYLEIPLD 160

                  ....*
gi 6320816    162 FIEYE 166
Cdd:pfam02776 161 VLLEE 165
PRK07524 PRK07524
5-guanidino-2-oxopentanoate decarboxylase;
2-530 6.01e-36

5-guanidino-2-oxopentanoate decarboxylase;


Pssm-ID: 236041 [Multi-domain]  Cd Length: 535  Bit Score: 141.27  E-value: 6.01e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     2 TTTATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQaaSYAASAYGY--ISDKPGVLLIVGGPGLIH 79
Cdd:PRK07524   1 MTTCGEALVRLLEAYGVETVFGIPGVHTVELYRGLAGSGIRHVTPRHEQ--GAGFMADGYarVSGKPGVCFIITGPGMTN 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    80 ALAGIYNSMSNRWPLLVIAGSSSQSDIHKG-GF-QEL-DQVSLLSPFLKFTGKL-TPDNIDMITQKALNYCIQGTAGVSY 155
Cdd:PRK07524  79 IATAMGQAYADSIPMLVISSVNRRASLGKGrGKlHELpDQRAMVAGVAAFSHTLmSAEDLPEVLARAFAVFDSARPRPVH 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   156 IDVPADFIEyekplEGNDRTGNELPMILTPNicGPDPSKIKKVVQLILQHKNKniLIVIGKGAVKNSHEIRRLVNTFNLP 235
Cdd:PRK07524 159 IEIPLDVLA-----APADHLLPAPPTRPARP--GPAPAALAQAAERLAAARRP--LILAGGGALAAAAALRALAERLDAP 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   236 FLPTPMAKGIVPDSSPLNVSSARS-----QALKIADIVLVLGARL---NWILHF-GTSPkwnSESIFIQFDSNPETLGDN 306
Cdd:PRK07524 230 VALTINAKGLLPAGHPLLLGASQSlpavrALIAEADVVLAVGTELgetDYDVYFdGGFP---LPGELIRIDIDPDQLARN 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   307 nvsPGADLSIWGDIGLSVTALVEEL-----TRQDSCWKYSGVKQEIREKIqlnqtrllrkektRGAQLNYNQVYGTLRPL 381
Cdd:PRK07524 307 ---YPPALALVGDARAALEALLARLpgqaaAADWGAARVAALRQALRAEW-------------DPLTAAQVALLDTILAA 370
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   382 IDDyrTILVTEGANTMDIARISFPTDAPRRRLDAGTN-ATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAV 460
Cdd:PRK07524 371 LPD--AIFVGDSTQPVYAGNLYFDADAPRRWFNASTGyGTLGYGLPAAIGAALGAPERPVVCLVGDGGLQFTLPELASAV 448
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6320816   461 RCQLALVIVVMNNSGIYHGEKDIEG-DLPPTALS-KNCRYDLVGKGLGANDFFVNTISELSRCFQQAVQLSR 530
Cdd:PRK07524 449 EADLPLIVLLWNNDGYGEIRRYMVArDIEPVGVDpYTPDFIALARAFGCAAERVADLEQLQAALRAAFARPG 520
TPP_enzyme_M pfam00205
Thiamine pyrophosphate enzyme, central domain; The central domain of TPP enzymes contains a ...
195-327 1.40e-35

Thiamine pyrophosphate enzyme, central domain; The central domain of TPP enzymes contains a 2-fold Rossman fold.


Pssm-ID: 425523 [Multi-domain]  Cd Length: 137  Bit Score: 129.99  E-value: 1.40e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    195 IKKVVQLILQHKNknILIVIGKGAV--KNSHEIRRLVNTFNLPFLPTPMAKGIVPDSSPLNV-------SSARSQALKIA 265
Cdd:pfam00205   1 IEKAAELLKKAKR--PVILAGGGVRrsGASEELRELAEKLGIPVVTTLMGKGAFPEDHPLYLgmlgmhgTPAANEALEEA 78
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6320816    266 DIVLVLGARLNWILHFGTSPKWNSESIFIQFDSNPETLGDNNvspGADLSIWGDIGLSVTAL 327
Cdd:pfam00205  79 DLVLAVGARFDDIRTTGKLPEFAPDAKIIHIDIDPAEIGKNY---PVDVPIVGDAKETLEAL 137
PRK08527 PRK08527
acetolactate synthase large subunit;
1-543 1.37e-34

acetolactate synthase large subunit;


Pssm-ID: 181458 [Multi-domain]  Cd Length: 563  Bit Score: 137.54  E-value: 1.37e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     1 MTTTATQHFAQLLQKYGIDTVFGIVGIPIVQLAD-TMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIH 79
Cdd:PRK08527   1 KKLSGSQMVCEALKEEGVKVVFGYPGGAILNIYDeIYKQNYFKHILTRHEQAAVHAADGYARASGKVGVAIVTSGPGFTN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    80 ALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLK--FTGKlTPDNIDMITQKALNYCIQGTAGVSYID 157
Cdd:PRK08527  81 AVTGLATAYMDSIPLVLISGQVPNSLIGTDAFQEIDAVGISRPCVKhnYLVK-SIEELPRILKEAFYIARSGRPGPVHID 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   158 VPADFI----EYEKPLEGNDRTgnelpmiLTPNICGpDPSKIKKVVQLIlqHKNKNILIVIGKGAVKN--SHEIRRLVNT 231
Cdd:PRK08527 160 IPKDVTatlgEFEYPKEISLKT-------YKPTYKG-NSRQIKKAAEAI--KEAKKPLFYLGGGAILSnaSEEIRELVKK 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   232 FNLPFLPTPMAKGIVPDSSPLNV-------SSARSQALKIADIVLVLGARlnwilhF-----GTSPKWNSESIFIQFDSN 299
Cdd:PRK08527 230 TGIPAVETLMARGVLRSDDPLLLgmlgmhgSYAANMAMSECDLLISLGAR------FddrvtGKLSEFAKHAKIIHVDID 303
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   300 PETLGdnNVSPgADLSIWGDIGLSVTALVEELtrqdscwkysgvKQEIREKIQLNQTRLLRKEKTRgaQLNYNQVYGTLR 379
Cdd:PRK08527 304 PSSIS--KIVN-ADYPIVGDLKNVLKEMLEEL------------KEENPTTYKEWREILKRYNELH--PLSYEDSDEVLK 366
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   380 P---------LIDDYRTILVTEGANTMDIARIsFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFG 450
Cdd:PRK08527 367 PqwviervgeLLGDDAIISTDVGQHQMWVAQF-YPFNYPRQLATSGGLGTMGYGLPAALGAKLAVPDKVVINFTGDGSIL 445
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   451 FSAMEIETAVRCQLALVIVVMNNS---------GIYHGEKDIEGDLpptalskNCRYDLV--GKGLGANDFFVNTISELS 519
Cdd:PRK08527 446 MNIQELMTAVEYKIPVINIILNNNflgmvrqwqTFFYEERYSETDL-------STQPDFVklAESFGGIGFRVTTKEEFD 518
                        570       580
                 ....*....|....*....|....
gi 6320816   520 RCFQQAVQlsrtKRETSVINVIIE 543
Cdd:PRK08527 519 KALKEALE----SDKVALIDVKID 538
PRK06112 PRK06112
acetolactate synthase catalytic subunit; Validated
3-484 2.42e-33

acetolactate synthase catalytic subunit; Validated


Pssm-ID: 235700 [Multi-domain]  Cd Length: 578  Bit Score: 134.12  E-value: 2.42e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     3 TTATQHFAQLLQKYGIDTVFGiVGIP-IVQLADTmvANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHAL 81
Cdd:PRK06112  14 GTVAHAIARALKRHGVEQIFG-QSLPsALFLAAE--AIGIRQIAYRTENAGGAMADGYARVSGKVAVVTAQNGPAATLLV 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    82 AGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYIDVPA 160
Cdd:PRK06112  91 APLAEALKASVPIVALVQDVNRDQTDRNAFQELDHIALFQSCTKWVRRVTvAERIDDYVDQAFTAATSGRPGPVVLLLPA 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   161 DFIEYEKPLEGNDRTGN--ELPMILTPnicgPDPSKIKKVVQLILQHKNKnilIVIGKGAVKNS---HEIRRLVNTFNLP 235
Cdd:PRK06112 171 DLLTAAAAAPAAPRSNSlgHFPLDRTV----PAPQRLAEAASLLAQAQRP---VVVAGGGVHISgasAALAALQSLAGLP 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   236 FLPTPMAKGIVPDSSPLNV----------SSARSQA--LKIADIVLVLGARLNwilHFGTSpKWN---SESIFIQFDSNP 300
Cdd:PRK06112 244 VATTNMGKGAVDETHPLSLgvvgslmgprSPGRHLRdlVREADVVLLVGTRTN---QNGTD-SWSlypEQAQYIHIDVDG 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   301 ETLGDNNVSpgadLSIWGDIGLSVTALVEELTRQD---SCWKYSGVKQEIREKIQLNQTRLLRKEKTRGAQLNYNQVYGT 377
Cdd:PRK06112 320 EEVGRNYEA----LRLVGDARLTLAALTDALRGRDlaaRAGRRAALEPAIAAGREAHREDSAPVALSDASPIRPERIMAE 395
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   378 LRPLIDDYRTILVTEGANTMDIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIE 457
Cdd:PRK06112 396 LQAVLTGDTIVVADASYSSIWVANFLTARRAGMRFLTPRGLAGLGWGVPMAIGAKVARPGAPVICLVGDGGFAHVWAELE 475
                        490       500
                 ....*....|....*....|....*..
gi 6320816   458 TAVRCQLALVIVVMNNsGIYHGEKDIE 484
Cdd:PRK06112 476 TARRMGVPVTIVVLNN-GILGFQKHAE 501
PRK06457 PRK06457
pyruvate dehydrogenase; Provisional
11-547 4.74e-31

pyruvate dehydrogenase; Provisional


Pssm-ID: 180570 [Multi-domain]  Cd Length: 549  Bit Score: 127.25  E-value: 4.74e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    11 QLLQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSMSN 90
Cdd:PRK06457  10 RVLEDNGIQRIYGIPGDSIDPLVDAIRKSKVKYVQVRHEEGAALAASVEAKITGKPSACMGTSGPGSIHLLNGLYDAKMD 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    91 RWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQgTAGVSYIDVPADFIEyekpl 169
Cdd:PRK06457  90 HAPVIALTGQVESDMIGHDYFQEVNLTKLFDDVAVFNQILInPENAEYIIRRAIREAIS-KRGVAHINLPVDILR----- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   170 EGNDRTGNELPMILTPNIcGPDPSKIKKVVQlilqhKNKNILIVIGKGAVKNSHEIRRLVNTFNLPFLPTPMAKGIVPDS 249
Cdd:PRK06457 164 KSSEYKGSKNTEVGKVKY-SIDFSRAKELIK-----ESEKPVLLIGGGTRGLGKEINRFAEKIGAPIIYTLNGKGILPDL 237
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   250 SP-------LNVSSARSQALKIADIVLVLGARlnwilhFGTSPKWNSESIFIQFDSNPETLGDNnvsPGADLSIWGDIGL 322
Cdd:PRK06457 238 DPkvmggigLLGTKPSIEAMDKADLLIMLGTS------FPYVNFLNKSAKVIQVDIDNSNIGKR---LDVDLSYPIPVAE 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   323 SVTALVEELTRQdscwKYSGVKQEIREKIQlnqtRLLRKEKTRGAQLNYNQVYGTLRPLIDDYRTILVTEGANTMDIARi 402
Cdd:PRK06457 309 FLNIDIEEKSDK----FYEELKGKKEDWLD----SISKQENSLDKPMKPQRVAYIVSQKCKKDAVIVTDTGNVTMWTAR- 379
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   403 SFPTDAPRRRLDAGTNATMGIGL-GYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVIVVMNNS--GIYHG 479
Cdd:PRK06457 380 HFRASGEQTFIFSAWLGSMGIGVpGSVGASFAVENKRQVISFVGDGGFTMTMMELITAKKYDLPVKIIIYNNSklGMIKF 459
                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6320816   480 EKDIEG------DLPPTALSKncrydlVGKGLGANDFFVNTISELSrcfqQAVQLSRTKRETSVINVIIEPGEQ 547
Cdd:PRK06457 460 EQEVMGypewgvDLYNPDFTK------IAESIGFKGFRLEEPKEAE----EIIEEFLNTKGPAVLDAIVDPNER 523
PRK06882 PRK06882
acetolactate synthase 3 large subunit;
11-473 1.12e-30

acetolactate synthase 3 large subunit;


Pssm-ID: 168717 [Multi-domain]  Cd Length: 574  Bit Score: 126.18  E-value: 1.12e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    11 QLLQKYGIDTVFGIVGIPIVQLADTM-VANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSMS 89
Cdd:PRK06882  12 QSLRDEGVEYVFGYPGGSVLDIYDAIhTLGGIEHVLVRHEQAAVHMADGYARSTGKVGCVLVTSGPGATNAITGIATAYT 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    90 NRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYIDVPADFIE---- 164
Cdd:PRK06882  92 DSVPLVILSGQVPSNLIGTDAFQECDMLGISRPVVKHSFIVKnAEDIPSTIKKAFYIASTGRPGPVVIDIPKDMVNpank 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   165 --YEKPLEGNDRTGNelpmiltPNICGpDPSKIKKVVQLILQHKnKNILIVIGKGAVKN-SHEIRRLVNTFNLPFLPTPM 241
Cdd:PRK06882 172 ftYEYPEEVSLRSYN-------PTVQG-HKGQIKKALKALLVAK-KPVLFVGGGVITAEcSEQLTQFAQKLNLPVTSSLM 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   242 AKGIVPDSSP-------LNVSSARSQALKIADIVLVLGARLNwILHFGTSPKWNSESIFIQFDSNPETLgDNNVSpgADL 314
Cdd:PRK06882 243 GLGAYPSTDKqflgmlgMHGTYEANNAMHESDLILGIGVRFD-DRTTNNLAKYCPNAKVIHIDIDPTSI-SKNVP--AYI 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   315 SIWGDIGLSVT---ALVEELTRQDSCWKYSGVKQEIREkiqLNQTRLLRKEKTRGAqLNYNQVYGTLRPLIDDYRTILVT 391
Cdd:PRK06882 319 PIVGSAKNVLEeflSLLEEENLAKSQTDLTAWWQQINE---WKAKKCLEFDRTSDV-IKPQQVVEAIYRLTNGDAYVASD 394
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   392 EGANTMdIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVIVVM 471
Cdd:PRK06882 395 VGQHQM-FAALHYPFDKPRRWINSGGAGTMGFGLPAAIGVKFAHPEATVVCVTGDGSIQMNIQELSTAKQYDIPVVIVSL 473

                 ..
gi 6320816   472 NN 473
Cdd:PRK06882 474 NN 475
PRK07282 PRK07282
acetolactate synthase large subunit;
3-473 2.86e-30

acetolactate synthase large subunit;


Pssm-ID: 180919 [Multi-domain]  Cd Length: 566  Bit Score: 124.93  E-value: 2.86e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     3 TTATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVAN-GIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHAL 81
Cdd:PRK07282  10 KSGSDLVLETLRDLGVDTIFGYPGGAVLPLYDAIYNFeGIRHILARHEQGALHEAEGYAKSTGKLGVAVVTSGPGATNAI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    82 AGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKL--TPDnIDMITQKALNYCIQGTAGVSYIDVP 159
Cdd:PRK07282  90 TGIADAMSDSVPLLVFTGQVARAGIGKDAFQEADIVGITMPITKYNYQIreTAD-IPRIITEAVHIATTGRPGPVVIDLP 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   160 ADFIEYEKPlEGNDRTGNeLPMiLTPNIcGPDPSKIKKVVQLILQHKNKNILIVIGKGAVKNSHEIRRLVNTFNLPFLPT 239
Cdd:PRK07282 169 KDVSALETD-FIYDPEVN-LPS-YQPTL-EPNDMQIKKILKQLSKAKKPVILAGGGINYAEAATELNAFAERYQIPVVTT 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   240 PMAKGIVPDSSPLNV-------SSARSQALKIADIVLVLGARLNWILhFGTSPKWNSESIFIQFDSNPETLGdNNVSpgA 312
Cdd:PRK07282 245 LLGQGTIATSHPLFLgmggmhgSYAANIAMTEADFMINIGSRFDDRL-TGNPKTFAKNAKVAHIDIDPAEIG-KIIK--T 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   313 DLSIWGDIGLSVTALVEELTrqdscwkysgVKQEIREKIqlnQTRLLRKEKTRgaqlNYNQVYGTLRP-----LIDDYR- 386
Cdd:PRK07282 321 DIPVVGDAKKALQMLLAEPT----------VHNNTEKWI---EKVTKDKNRVR----SYDKKERVVQPqavieRIGELTn 383
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   387 --TILVTE-GANTMDIARIsFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQ 463
Cdd:PRK07282 384 gdAIVVTDvGQHQMWAAQY-YPYQNERQLVTSGGLGTMGFGIPAAIGAKIANPDKEVILFVGDGGFQMTNQELAILNIYK 462
                        490
                 ....*....|
gi 6320816   464 LALVIVVMNN 473
Cdd:PRK07282 463 VPIKVVMLNN 472
PRK06466 PRK06466
acetolactate synthase 3 large subunit;
11-473 2.05e-29

acetolactate synthase 3 large subunit;


Pssm-ID: 180578 [Multi-domain]  Cd Length: 574  Bit Score: 122.55  E-value: 2.05e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    11 QLLQKYGIDTVFGIVGIPIVQLADTMV-ANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSMS 89
Cdd:PRK06466  12 RALRDEGVEYIYGYPGGAVLHIYDALFkQDKVEHILVRHEQAATHMADGYARATGKTGVVLVTSGPGATNAITGIATAYM 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    90 NRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYIDVPADF------ 162
Cdd:PRK06466  92 DSIPMVVLSGQVPSTLIGEDAFQETDMVGISRPIVKHSFMVKhASEIPEIIKKAFYIAQSGRPGPVVVDIPKDMtnpaek 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   163 IEYEKPLEGNDRTgnelpmiLTPNICGpDPSKIKKVVQLILQHKNKniLIVIGKGAV--KNSHEIRRLVNTFNLPFLPTP 240
Cdd:PRK06466 172 FEYEYPKKVKLRS-------YSPAVRG-HSGQIRKAVEMLLAAKRP--VIYSGGGVVlgNASALLTELAHLLNLPVTNTL 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   241 MAKGIVPDSSPLNV-------SSARSQALKIADIVLVLGARLNWILHFGTSpKWNSESIFIQFDSNPETLGDNNVspgAD 313
Cdd:PRK06466 242 MGLGGFPGTDRQFLgmlgmhgTYEANMAMHHADVILAVGARFDDRVTNGPA-KFCPNAKIIHIDIDPASISKTIK---AD 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   314 LSIWGDIGLSVTALVEELTRQDSC---------WKysgvkqeirekiQLNQTR----LLRKEKTRGAQLNYNQVYGTLRP 380
Cdd:PRK06466 318 IPIVGPVESVLTEMLAILKEIGEKpdkealaawWK------------QIDEWRgrhgLFPYDKGDGGIIKPQQVVETLYE 385
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   381 LIDDYRTILVTEGANTMdIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAV 460
Cdd:PRK06466 386 VTNGDAYVTSDVGQHQM-FAAQYYKFNKPNRWINSGGLGTMGFGLPAAMGVKLAFPDQDVACVTGEGSIQMNIQELSTCL 464
                        490
                 ....*....|...
gi 6320816   461 RCQLALVIVVMNN 473
Cdd:PRK06466 465 QYGLPVKIINLNN 477
PRK08979 PRK08979
acetolactate synthase 3 large subunit;
17-473 2.53e-29

acetolactate synthase 3 large subunit;


Pssm-ID: 181602 [Multi-domain]  Cd Length: 572  Bit Score: 122.24  E-value: 2.53e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    17 GIDTVFGIVGIPIVQLADTM-VANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSMSNRWPLL 95
Cdd:PRK08979  18 GVKHIFGYPGGSVLDIYDALhEKSGIEHILVRHEQAAVHMADGYARATGKVGVVLVTSGPGATNTITGIATAYMDSIPMV 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    96 VIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYIDVPADFI------EYEKP 168
Cdd:PRK08979  98 VLSGQVPSNLIGNDAFQECDMIGISRPVVKHSFLVKdAEDIPEIIKKAFYIASTGRPGPVVIDLPKDCLnpailhPYEYP 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   169 LEGNDRTGNelpmiltPNICGpDPSKIKKVVQLILQHKnKNILIVIGKGAVKNSHE-IRRLVNTFNLPFLPTPMAKGIVP 247
Cdd:PRK08979 178 ESIKMRSYN-------PTTSG-HKGQIKRGLQALLAAK-KPVLYVGGGAIISGADKqILQLAEKLNLPVVSTLMGLGAFP 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   248 DSSPLNVSS-------ARSQALKIADIVLVLGARLNwilHFGTS--PKWNSESIFIQFDSNPETLGDNnvsPGADLSIWG 318
Cdd:PRK08979 249 GTHKNSLGMlgmhgryEANMAMHNADLIFGIGVRFD---DRTTNnlEKYCPNATILHIDIDPSSISKT---VRVDIPIVG 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   319 DIGLSVTALVEELTRQDSCWKYSGVKQEIREKIQLNQTRLLRKEKTRGaQLNYNQVYGTLRPLIDDYRTILVTEGANTMd 398
Cdd:PRK08979 323 SADKVLDSMLALLDESGETNDEAAIASWWNEIEVWRSRNCLAYDKSSE-RIKPQQVIETLYKLTNGDAYVASDVGQHQM- 400
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6320816   399 IARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVIVVMNN 473
Cdd:PRK08979 401 FAALYYPFDKPRRWINSGGLGTMGFGLPAAMGVKFAMPDETVVCVTGDGSIQMNIQELSTALQYDIPVKIINLNN 475
PRK06154 PRK06154
thiamine pyrophosphate-requiring protein;
2-554 5.39e-29

thiamine pyrophosphate-requiring protein;


Pssm-ID: 235718 [Multi-domain]  Cd Length: 565  Bit Score: 121.07  E-value: 5.39e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     2 TTTATQHFAQLLQKYGIDTVFGIvgiPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYIS--DKPGVLLIVGGPGLIH 79
Cdd:PRK06154  19 TMKVAEAVAEILKEEGVELLFGF---PVNELFDAAAAAGIRPVIARTERVAVHMADGYARATsgERVGVFAVQYGPGAEN 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    80 ALAGIYNSMSNRWPLLVIAGSSSQSDIH-KGGFQELDQvslLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYID 157
Cdd:PRK06154  96 AFGGVAQAYGDSVPVLFLPTGYPRGSTDvAPNFESLRN---YRHITKWCEQVTlPDEVPELMRRAFTRLRNGRPGPVVLE 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   158 VPADFIEYEKPlegndrtgnELPMILTPN---ICGPDPSKIKKVVQLILQHKNKNILIVIGKGAVKNSHEIRRLVNTFNL 234
Cdd:PRK06154 173 LPVDVLAEELD---------ELPLDHRPSrrsRPGADPVEVVEAAALLLAAERPVIYAGQGVLYAQATPELKELAELLEI 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   235 PFLPTPMAKGIVPDSSPLNVSSAR-------SQALKIADIVLVLGARLNWILHFGTSPKwnsESIFIQFDSNPETLGDNN 307
Cdd:PRK06154 244 PVMTTLNGKSAFPEDHPLALGSGGrarpatvAHFLREADVLFGIGCSLTRSYYGLPMPE---GKTIIHSTLDDADLNKDY 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   308 VSpgaDLSIWGDIGLSVTALVEELTRQ--DSCWKYSGVKQEIREKIQLNQTRLLRKEKTRGAQLNYNQVYGTLRPLIDDY 385
Cdd:PRK06154 321 PI---DHGLVGDAALVLKQMIEELRRRvgPDRGRAQQVAAEIEAVRAAWLAKWMPKLTSDSTPINPYRVVWELQHAVDIK 397
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   386 RTILVTEGANTMDIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLA 465
Cdd:PRK06154 398 TVIITHDAGSPRDQLSPFYVASRPGSYLGWGKTTQLGYGLGLAMGAKLARPDALVINLWGDAAFGMTGMDFETAVRERIP 477
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   466 LVIVVMNNS--GIY----------HGEKDIEGDlpptalskncrYDLVGKGLGANDFFVNTISELSRCFQQAVQLSRTKR 533
Cdd:PRK06154 478 ILTILLNNFsmGGYdkvmpvsttkYRATDISGD-----------YAAIARALGGYGERVEDPEMLVPALLRALRKVKEGT 546
                        570       580
                 ....*....|....*....|.
gi 6320816   534 eTSVINVIIepGEQKQIAFAW 554
Cdd:PRK06154 547 -PALLEVIT--SEETALSRPW 564
PRK06048 PRK06048
acetolactate synthase large subunit;
4-543 5.80e-29

acetolactate synthase large subunit;


Pssm-ID: 180368 [Multi-domain]  Cd Length: 561  Bit Score: 121.04  E-value: 5.80e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     4 TATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAG 83
Cdd:PRK06048   9 TGARAIIKCLEKEGVEVIFGYPGGAIIPVYDELYDSDLRHILVRHEQAAAHAADGYARATGKVGVCVATSGPGATNLVTG 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    84 IYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYIDVPADF 162
Cdd:PRK06048  89 IATAYMDSVPIVALTGQVPRSMIGNDAFQEADITGITMPITKHNYLVQdAKDLPRIIKEAFHIASTGRPGPVLIDLPKDV 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   163 IEYEKPLEGNDRTgnELPMiLTPNICGpDPSKIKKVVQLILqhKNKNILIVIGKGAVKN--SHEIRRLVNTFNLPFLPTP 240
Cdd:PRK06048 169 TTAEIDFDYPDKV--ELRG-YKPTYKG-NPQQIKRAAELIM--KAERPIIYAGGGVISSnaSEELVELAETIPAPVTTTL 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   241 MAKGIVPDSSPLNV-------SSARSQALKIADIVLVLGARLNWILHfGTSPKWNSESIFIQFDSNPETLGDN-NVspga 312
Cdd:PRK06048 243 MGIGAIPTEHPLSLgmlgmhgTKYANYAIQESDLIIAVGARFDDRVT-GKLASFAPNAKIIHIDIDPAEISKNvKV---- 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   313 DLSIWGDIGLSVTALVEELTRQDScwkysgvkQEIREKIqlNQTRllrkektRGAQLNYNQVYGTLRP---------LID 383
Cdd:PRK06048 318 DVPIVGDAKQVLKSLIKYVQYCDR--------KEWLDKI--NQWK-------KEYPLKYKEREDVIKPqyvieqiyeLCP 380
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   384 DyrTILVTE-GANTMDIARIsFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRC 462
Cdd:PRK06048 381 D--AIIVTEvGQHQMWAAQY-FKYKYPRTFITSGGLGTMGYGFPAAIGAKVGKPDKTVIDIAGDGSFQMNSQELATAVQN 457
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   463 QLALVIVVMNNSgiYHG------EKDIEGDLPPTALSKNCRYDLVGKGLGANDFFVNTISELSRCFQQAVQLSRtkreTS 536
Cdd:PRK06048 458 DIPVIVAILNNG--YLGmvrqwqELFYDKRYSHTCIKGSVDFVKLAEAYGALGLRVEKPSEVRPAIEEAVASDR----PV 531

                 ....*..
gi 6320816   537 VINVIIE 543
Cdd:PRK06048 532 VIDFIVE 538
PRK08327 PRK08327
thiamine pyrophosphate-requiring protein;
60-544 1.66e-28

thiamine pyrophosphate-requiring protein;


Pssm-ID: 236243 [Multi-domain]  Cd Length: 569  Bit Score: 119.72  E-value: 1.66e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    60 GY--ISDKPGVLLIVGGPGLIHALAGIYNSMSNRWPLLVIAGSSSQSD----------IHKGgfQE-LDQVSLLSPFLKF 126
Cdd:PRK08327  68 GYalVTGKPQAVMVHVDVGTANALGGVHNAARSRIPVLVFAGRSPYTEegelgsrntrIHWT--QEmRDQGGLVREYVKW 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   127 TGKL-TPDNIDMITQKALNYCIQGTAGVSYIDVPADFIEYEKPLEGNDRTGNelpmiLTPNICGPDPSKIKKVVQLILQH 205
Cdd:PRK08327 146 DYEIrRGDQIGEVVARAIQIAMSEPKGPVYLTLPREVLAEEVPEVKADAGRQ-----MAPAPPAPDPEDIARAAEMLAAA 220
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   206 KNKniLIVIGKGAvkNSHE----IRRLVNTFNLP---FLPTPMAkgiVPDSSPLNVSSARSQALKIADIVLVLGARLNWI 278
Cdd:PRK08327 221 ERP--VIITWRAG--RTAEgfasLRRLAEELAIPvveYAGEVVN---YPSDHPLHLGPDPRADLAEADLVLVVDSDVPWI 293
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   279 lhfgtsPKWNSESI---FIQFDSNPeTLGDNNV-SPGADLSIWGDIGLSVTALVEELTRQDS-----CWKYSGVKQEIRE 349
Cdd:PRK08327 294 ------PKKIRPDAdarVIQIDVDP-LKSRIPLwGFPCDLCIQADTSTALDQLEERLKSLASaerrrARRRRAAVRELRI 366
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   350 KIQLNQTRLLRKEKTRG----AQLNYnqvygTLRPLIDDYRTIlVTEGANTMDIARisfpTDAPRRRLDAGTNATMGIGL 425
Cdd:PRK08327 367 RQEAAKRAEIERLKDRGpitpAYLSY-----CLGEVADEYDAI-VTEYPFVPRQAR----LNKPGSYFGDGSAGGLGWAL 436
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   426 GYALACKASHPELDVVLIQGDSAFGFSAmeiETAV-----RCQLALVIVVMNNSG----------IY-HGEKDIEGDLPP 489
Cdd:PRK08327 437 GAALGAKLATPDRLVIATVGDGSFIFGV---PEAAhwvaeRYGLPVLVVVFNNGGwlavkeavleVYpEGYAARKGTFPG 513
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 6320816   490 TALSKNCRYDLVGKGLGANDFFVNTISELSRCFQQAVQLSRTKRETSVINVIIEP 544
Cdd:PRK08327 514 TDFDPRPDFAKIAEAFGGYGERVEDPEELKGALRRALAAVRKGRRSAVLDVIVDR 568
PRK07979 PRK07979
acetolactate synthase 3 large subunit;
17-473 6.08e-28

acetolactate synthase 3 large subunit;


Pssm-ID: 181185 [Multi-domain]  Cd Length: 574  Bit Score: 118.03  E-value: 6.08e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    17 GIDTVFGIVGIPIVQLADTM-VANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSMSNRWPLL 95
Cdd:PRK07979  18 GVKQVFGYPGGAVLDIYDALhTVGGIDHVLVRHEQAAVHMADGLARATGEVGVVLVTSGPGATNAITGIATAYMDSIPLV 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    96 VIAGSSSQSDIHKGGFQELDQVSLLSPFLK--FTGKLTPDnIDMITQKALNYCIQGTAGVSYIDVPADFIE------YEK 167
Cdd:PRK07979  98 VLSGQVATSLIGYDAFQECDMVGISRPVVKhsFLVKQTED-IPQVLKKAFWLAASGRPGPVVVDLPKDILNpanklpYVW 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   168 PLEGNDRTGNelpmiltPNICGpDPSKIKKVVQLILQHKNKniLIVIGKGAVkNSH---EIRRLVNTFNLPFLPTPMAKG 244
Cdd:PRK07979 177 PESVSMRSYN-------PTTQG-HKGQIKRALQTLVAAKKP--VVYVGGGAI-NAAchqQLKELVEKLNLPVVSSLMGLG 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   245 IVPDSSPLNV-------SSARSQALKIADIVLVLGARLNwILHFGTSPKWNSESIFIQFDSNPETLGDnnvSPGADLSIW 317
Cdd:PRK07979 246 AFPATHRQSLgmlgmhgTYEANMTMHNADVIFAVGVRFD-DRTTNNLAKYCPNATVLHIDIDPTSISK---TVTADIPIV 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   318 GDIGLSVTALVEELTRQDSCWKYSGVKqEIREKIQLNQTRLLRKEKTRGAQLNYNQVYGTLRPLIDDYRTILVTEGANTM 397
Cdd:PRK07979 322 GDARQVLEQMLELLSQESAHQPLDEIR-DWWQQIEQWRARQCLKYDTHSEKIKPQAVIETLWRLTKGDAYVTSDVGQHQM 400
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6320816   398 dIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVIVVMNN 473
Cdd:PRK07979 401 -FAALYYPFDKPRRWINSGGLGTMGFGLPAALGVKMALPEETVVCVTGDGSIQMNIQELSTALQYELPVLVLNLNN 475
PRK08155 PRK08155
acetolactate synthase large subunit;
1-483 7.91e-26

acetolactate synthase large subunit;


Pssm-ID: 181257 [Multi-domain]  Cd Length: 564  Bit Score: 111.34  E-value: 7.91e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     1 MTTTATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANG-IKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIH 79
Cdd:PRK08155  11 KRFTGAELIVRLLERQGIRIVTGIPGGAILPLYDALSQSTqIRHILARHEQGAGFIAQGMARTTGKPAVCMACSGPGATN 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    80 ALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKL-TPDNIDMITQKALNYCIQGTAGVSYIDV 158
Cdd:PRK08155  91 LVTAIADARLDSIPLVCITGQVPASMIGTDAFQEVDTYGISIPITKHNYLVrDIEELPQVISDAFRIAQSGRPGPVWIDI 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   159 PADFIEYEKPLEgndrtgnELPMILTPN-ICGPDPSKIKKVVQLILQHKNKniLIVIGKGAVKN--SHEIRRLVNTFNLP 235
Cdd:PRK08155 171 PKDVQTAVIELE-------ALPAPAEKDaAPAFDEESIRDAAAMINAAKRP--VLYLGGGVINSgaPARARELAEKAQLP 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   236 FLPTPMAKGIVPDSSPLNVS-----SARSQ--ALKIADIVLVLGARlnwilhF-----GTSPKWNSESIFIQFDSNPETL 303
Cdd:PRK08155 242 TTMTLMALGMLPKAHPLSLGmlgmhGARSTnyILQEADLLIVLGAR------FddraiGKTEQFCPNAKIIHVDIDRAEL 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   304 GdnNVSPgADLSIWGDIGLSVTALVEELTRQDscwkysgvKQEIREKIQLNQTRLLRKEKTRGAQLNYnqvYGTLRPL-- 381
Cdd:PRK08155 316 G--KIKQ-PHVAIQADVDDVLAQLLPLVEAQP--------RAEWHQLVADLQREFPCPIPKADDPLSH---YGLINAVaa 381
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   382 -IDDYRTILVTEGANTMDIARiSFPTDAPRRRLDAGTNATMGIGL----GYALACkashPELDVVLIQGDSAFGFSAMEI 456
Cdd:PRK08155 382 cVDDNAIITTDVGQHQMWTAQ-AYPLNRPRQWLTSGGLGTMGFGLpaaiGAALAN----PERKVLCFSGDGSLMMNIQEM 456
                        490       500
                 ....*....|....*....|....*....
gi 6320816   457 ETAVRCQLALVIVVMNNS--GIYHGEKDI 483
Cdd:PRK08155 457 ATAAENQLDVKIILMNNEalGLVHQQQSL 485
ilvB CHL00099
acetohydroxyacid synthase large subunit
6-473 1.83e-25

acetohydroxyacid synthase large subunit


Pssm-ID: 214363 [Multi-domain]  Cd Length: 585  Bit Score: 110.56  E-value: 1.83e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     6 TQHFAQL--LQKYGIDTVFGIVGIPIVQLADTMVA----NGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIH 79
Cdd:CHL00099  11 TGAFALIdsLVRHGVKHIFGYPGGAILPIYDELYAwekkGLIKHILVRHEQGAAHAADGYARSTGKVGVCFATSGPGATN 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    80 ALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKL-TPDNIDMITQKALNYCIQGTAGVSYIDV 158
Cdd:CHL00099  91 LVTGIATAQMDSVPLLVITGQVGRAFIGTDAFQEVDIFGITLPIVKHSYVVrDARDISRIVAEAFYIAKHGRPGPVLIDI 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   159 PADF----IEYEKPLEGNdrtgNELPMILTPNICGPDPSKIKKVVQLILQHKNKniLIVIGKGAV--KNSHEIRRLVNTF 232
Cdd:CHL00099 171 PKDVglekFDYYPPEPGN----TIIKILGCRPIYKPTIKRIEQAAKLILQSSQP--LLYVGGGAIisDAHQEITELAELY 244
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   233 NLPFLPTPMAKGIVPDSSPLNV-------SSARSQALKIADIVLVLGARlnwilhF-----GTSPKWNSESIFIQFDSNP 300
Cdd:CHL00099 245 KIPVTTTLMGKGIFDEDHPLCLgmlgmhgTAYANFAVSECDLLIALGAR------FddrvtGKLDEFACNAQVIHIDIDP 318
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   301 ETLGDNNVSpgaDLSIWGDIGLSVTALVEELTRQDSCWkYSGVKQEIREKIQL--NQTRLL--RKEKTRGAQLNYNQVyG 376
Cdd:CHL00099 319 AEIGKNRIP---QVAIVGDVKKVLQELLELLKNSPNLL-ESEQTQAWRERINRwrKEYPLLipKPSTSLSPQEVINEI-S 393
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   377 TLRPliDDYRTILVteGANTMDIARisFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEI 456
Cdd:CHL00099 394 QLAP--DAYFTTDV--GQHQMWAAQ--FLKCKPRKWLSSAGLGTMGYGLPAAIGAQIAHPNELVICISGDASFQMNLQEL 467
                        490
                 ....*....|....*..
gi 6320816   457 ETAVRCQLALVIVVMNN 473
Cdd:CHL00099 468 GTIAQYNLPIKIIIINN 484
PRK07418 PRK07418
acetolactate synthase large subunit;
13-473 5.39e-25

acetolactate synthase large subunit;


Pssm-ID: 236014 [Multi-domain]  Cd Length: 616  Bit Score: 109.37  E-value: 5.39e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    13 LQKYGIDTVFGIVGIPIVQLADTMV---ANG-IKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSM 88
Cdd:PRK07418  29 LKRHGVKHIFGYPGGAILPIYDELYkaeAEGwLKHILVRHEQGAAHAADGYARATGKVGVCFGTSGPGATNLVTGIATAQ 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    89 SNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKL-TPDNIDMITQKALNYCIQGTAGVSYIDVPAD----FI 163
Cdd:PRK07418 109 MDSVPMVVITGQVPRPAIGTDAFQETDIFGITLPIVKHSYVVrDPSDMARIVAEAFHIASSGRPGPVLIDIPKDvgqeEF 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   164 EYEkPLEgndrTGNELPMILTPNIcGPDPSKIKKVVQLILQHKNKniLIVIGKGAVK-NSH-EIRRLVNTFNLPFLPTPM 241
Cdd:PRK07418 189 DYV-PVE----PGSVKPPGYRPTV-KGNPRQINAALKLIEEAERP--LLYVGGGAISaGAHaELKELAERFQIPVTTTLM 260
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   242 AKGIVPDSSPLNVS------SARSQ-ALKIADIVLVLGARlnwilhF-----GTSPKWNSESIFIQFDSNPETLGDNNVs 309
Cdd:PRK07418 261 GKGAFDEHHPLSVGmlgmhgTAYANfAVTECDLLIAVGAR------FddrvtGKLDEFASRAKVIHIDIDPAEVGKNRR- 333
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   310 pgADLSIWGDIGLSVTALVEELTRQdscwKYSGVKQEIREKIQLNQTRLLRKEKTRGAQLNYNQVYGTLRPLIDD-YRTI 388
Cdd:PRK07418 334 --PDVPIVGDVRKVLVKLLERSLEP----TTPPRTQAWLERINRWKQDYPLVVPPYEGEIYPQEVLLAVRDLAPDaYYTT 407
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   389 LVteGANTMDIARisFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVI 468
Cdd:PRK07418 408 DV--GQHQMWAAQ--FLRNGPRRWISSAGLGTMGFGMPAAMGVKVALPDEEVICIAGDASFLMNIQELGTLAQYGINVKT 483

                 ....*
gi 6320816   469 VVMNN 473
Cdd:PRK07418 484 VIINN 488
PRK06456 PRK06456
acetolactate synthase large subunit;
13-527 5.73e-25

acetolactate synthase large subunit;


Pssm-ID: 180569 [Multi-domain]  Cd Length: 572  Bit Score: 108.77  E-value: 5.73e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    13 LQKYGIDTVFGIVGIPIVQLADTM---VANG-IKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSM 88
Cdd:PRK06456  12 LKREGVKVIFGIPGLSNMQIYDAFvedLANGeLRHVLMRHEQAAAHAADGYARASGVPGVCTATSGPGTTNLVTGLITAY 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    89 SNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKL-TPDNIDMITQKALNYCIQGTAGVSYIDVPADfIEYEK 167
Cdd:PRK06456  92 WDSSPVIAITGQVPRSVMGKMAFQEADAMGVFENVTKYVIGIkRIDEIPQWIKNAFYIATTGRPGPVVIDIPRD-IFYEK 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   168 ---------PLEGNDRtgnELPMILtpnicgpDPSKIKKVVQLILQHKNKniLIVIGKGAV--KNSHEIRRLVNTFNLPF 236
Cdd:PRK06456 171 meeikwpekPLVKGYR---DFPTRI-------DRLALKKAAEILINAERP--IILVGTGVVwsNATPEVLELAELLHIPI 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   237 LPTPMAKGIVPDSSPLNVSS----ARSQALKIA---DIVLVLGARLnwilhfgtspkwnSESIFIQFDSNPET---LGDN 306
Cdd:PRK06456 239 VSTFPGKTAIPHDHPLYFGPmgyyGRAEASMAAlesDAMLVVGARF-------------SDRTFTSYDEMVETrkkFIMV 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   307 NVSPG-------ADLSIWGDIGL----SVTALVEELTRQD-SCWkysgvkqeirekiqlnqTRLLRKEKTRGAQLNYNQV 374
Cdd:PRK06456 306 NIDPTdgekaikVDVGIYGNAKIilreLIKAITELGQKRDrSAW-----------------LKRVKEYKEYYSQFYYTEE 368
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   375 YGTLRP--LIDDYRTIL-----VTEGANTMDI-ARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGD 446
Cdd:PRK06456 369 NGKLKPwkIMKTIRQALprdaiVTTGVGQHQMwAEVFWEVLEPRTFLTSSGMGTMGFGLPAAMGAKLARPDKVVVDLDGD 448
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   447 SAFGFSAMEIETAVRCQLALVIVVMNN---------SGIYHGEKDIEGDLPPTAlskncryDLV--GKGLGANDFFVNTI 515
Cdd:PRK06456 449 GSFLMTGTNLATAVDEHIPVISVIFDNrtlglvrqvQDLFFGKRIVGVDYGPSP-------DFVklAEAFGALGFNVTTY 521
                        570
                 ....*....|..
gi 6320816   516 SELSRCFQQAVQ 527
Cdd:PRK06456 522 EDIEKSLKSAIK 533
PRK06965 PRK06965
acetolactate synthase 3 catalytic subunit; Validated
13-473 6.82e-24

acetolactate synthase 3 catalytic subunit; Validated


Pssm-ID: 180780 [Multi-domain]  Cd Length: 587  Bit Score: 105.66  E-value: 6.82e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    13 LQKYGIDTVFGIVGIPIVQLADTMVA-NGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSMSNR 91
Cdd:PRK06965  31 LAAEGVEFIWGYPGGAVLYIYDELYKqDKIQHVLVRHEQAAVHAADGYARATGKVGVALVTSGPGVTNAVTGIATAYMDS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    92 WPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLK--FTGKlTPDNIDMITQKALNYCIQGTAGVSYIDVPADF----IEY 165
Cdd:PRK06965 111 IPMVVISGQVPTAAIGQDAFQECDTVGITRPIVKhnFLVK-DVRDLAETVKKAFYIARTGRPGPVVVDIPKDVsktpCEY 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   166 EKPLEGNDRTGNelpmiltPNICGpDPSKIKKVVQLILQHKNKniLIVIGKGAV--KNSHEIRRLVNTFNLPFLPTPMAK 243
Cdd:PRK06965 190 EYPKSVEMRSYN-------PVTKG-HSGQIRKAVSLLLSAKRP--YIYTGGGVIlaNASRELRQLADLLGYPVTNTLMGL 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   244 GIVPDSSP-------LNVSSARSQALKIADIVLVLGARLNWIL-----HFGTSPKwnsesIFIQFDSNPETLGDNnvsPG 311
Cdd:PRK06965 260 GAYPASDKkflgmlgMHGTYEANMAMQHCDVLIAIGARFDDRVignpaHFASRPR-----KIIHIDIDPSSISKR---VK 331
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   312 ADLSIWGDIGLSVTALVEELtRQDSCWKYSGVKQEIREKIQLNQTRLLRKEKTRGAQLNYNQVYGTLRPLIDDYRTILVT 391
Cdd:PRK06965 332 VDIPIVGDVKEVLKELIEQL-QTAEHGPDADALAQWWKQIEGWRSRDCLKYDRESEIIKPQYVVEKLWELTDGDAFVCSD 410
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   392 EGANTMDIARIsFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVIVVM 471
Cdd:PRK06965 411 VGQHQMWAAQF-YRFNEPRRWINSGGLGTMGVGLPYAMGIKMAHPDDDVVCITGEGSIQMCIQELSTCLQYDTPVKIISL 489

                 ..
gi 6320816   472 NN 473
Cdd:PRK06965 490 NN 491
TPP_enzymes cd00568
Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic ...
373-542 1.38e-23

Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and the branched chain alpha-keto acid dehydrogenase complexes.


Pssm-ID: 238318 [Multi-domain]  Cd Length: 168  Bit Score: 97.33  E-value: 1.38e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  373 QVYGTLRPLIDDyRTILVTEGANTMDIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFS 452
Cdd:cd00568   1 RVLAALRAALPE-DAIVVNDAGNSAYWAYRYLPLRRGRRFLTSTGFGAMGYGLPAAIGAALAAPDRPVVCIAGDGGFMMT 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  453 AMEIETAVRCQLALVIVVMNNSG---IYHGEKDIEGDLPPTALSKNCRYDLVGKGLGANDFFVNTISELSRCFQQAvqls 529
Cdd:cd00568  80 GQELATAVRYGLPVIVVVFNNGGygtIRMHQEAFYGGRVSGTDLSNPDFAALAEAYGAKGVRVEDPEDLEAALAEA---- 155
                       170
                ....*....|...
gi 6320816  530 RTKRETSVINVII 542
Cdd:cd00568 156 LAAGGPALIEVKT 168
PRK09107 PRK09107
acetolactate synthase 3 catalytic subunit; Validated
11-473 2.85e-23

acetolactate synthase 3 catalytic subunit; Validated


Pssm-ID: 236380 [Multi-domain]  Cd Length: 595  Bit Score: 103.63  E-value: 2.85e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    11 QLLQKYGIDTVFGIVGIPIVQLADTMVA-NGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSMS 89
Cdd:PRK09107  19 QALKDQGVEHIFGYPGGAVLPIYDEIFQqDDIQHILVRHEQGAGHAAEGYARSTGKPGVVLVTSGPGATNAVTPLQDALM 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    90 NRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGkLTPDNIDM--ITQKALNYCIQGTAGVSYIDVPAD--FI-- 163
Cdd:PRK09107  99 DSIPLVCITGQVPTHLIGSDAFQECDTVGITRPCTKHNW-LVKDVNDLarVIHEAFHVATSGRPGPVVVDIPKDvqFAtg 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   164 EYEKPLEGNDRTGnelpmiLTPNICGpDPSKIKKVVQLILQHKNKniLIVIGKGAV----KNSHEIRRLVNTFNLPFLPT 239
Cdd:PRK09107 178 TYTPPQKAPVHVS------YQPKVKG-DAEAITEAVELLANAKRP--VIYSGGGVInsgpEASRLLRELVELTGFPITST 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   240 PMAKGIVPDSSP-------LNVSSARSQALKIADIVLVLGARLN-----WILHFgtSPkwNSESIFIQFDsnPETLgDNN 307
Cdd:PRK09107 249 LMGLGAYPASGKnwlgmlgMHGTYEANMAMHDCDVMLCVGARFDdritgRLDAF--SP--NSKKIHIDID--PSSI-NKN 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   308 VSpgADLSIWGDIGlsvtALVEELTRqdsCWKYSGVKQEiREKIQLNQTRLlrkEKTRGAQ-LNYNQVYGTLRP------ 380
Cdd:PRK09107 322 VR--VDVPIIGDVG----HVLEDMLR---LWKARGKKPD-KEALADWWGQI---ARWRARNsLAYTPSDDVIMPqyaiqr 388
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   381 ---LIDDYRTILVTE-GANTMDIARIsFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEI 456
Cdd:PRK09107 389 lyeLTKGRDTYITTEvGQHQMWAAQF-FGFEEPNRWMTSGGLGTMGYGLPAALGVQIAHPDALVIDIAGDASIQMCIQEM 467
                        490
                 ....*....|....*..
gi 6320816   457 ETAVRCQLALVIVVMNN 473
Cdd:PRK09107 468 STAVQYNLPVKIFILNN 484
PRK11269 PRK11269
glyoxylate carboligase; Provisional
4-543 1.17e-22

glyoxylate carboligase; Provisional


Pssm-ID: 183066 [Multi-domain]  Cd Length: 591  Bit Score: 101.98  E-value: 1.17e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     4 TATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANG-IKFIPCRNEQAASYAASayGYISDKPG---VLLIVGGPGLIH 79
Cdd:PRK11269   5 RAVDAAVLVLEKEGVTTAFGVPGAAINPFYSAMRKHGgIRHILARHVEGASHMAE--GYTRATAGnigVCIGTSGPAGTD 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    80 ALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKF-TGKLTPDNIDMITQKALNYCIQGTAGVSYIDV 158
Cdd:PRK11269  83 MITGLYSASADSIPILCITGQAPRARLHKEDFQAVDIESIAKPVTKWaVTVREPALVPRVFQQAFHLMRSGRPGPVLIDL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   159 PADF----IEYEkplegnDRTGNELPmILTPnicGPDPSKIKKVVQLILQHKNKniLIVIGkGAVKN---SHEIRRLVNT 231
Cdd:PRK11269 163 PFDVqvaeIEFD------PDTYEPLP-VYKP---AATRAQIEKALEMLNAAERP--LIVAG-GGVINadaSDLLVEFAEL 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   232 FNLPFLPTPMAKGIVPDSSPLNV------SSAR--SQALKIADIVLVLGARlnWI-LHFGTSPKWNSESIFIQFDSNPET 302
Cdd:PRK11269 230 TGVPVIPTLMGWGAIPDDHPLMAgmvglqTSHRygNATLLASDFVLGIGNR--WAnRHTGSVEVYTKGRKFVHVDIEPTQ 307
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   303 LGdnNVSpGADLSIWGDIGLSVTALVeELTRQdscWKYSGVKQEIREKIQLNQTR---LLRKEKTRGAQLNYNQVYGTLR 379
Cdd:PRK11269 308 IG--RVF-GPDLGIVSDAKAALELLV-EVARE---WKAAGRLPDRSAWVADCQERkrtLLRKTHFDNVPIKPQRVYEEMN 380
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   380 PLIDDyRTILVTeganTMDIARIS----FPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFsaME 455
Cdd:PRK11269 381 KAFGR-DTCYVS----TIGLSQIAaaqfLHVYKPRHWINCGQAGPLGWTIPAALGVRAADPDRNVVALSGDYDFQF--LI 453
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   456 IETAVRCQLAL--VIVVMNNSgiYHG---------EKDIEGDL------PPTALSKNCRYDLVGKGLGANDFFVNTISEL 518
Cdd:PRK11269 454 EELAVGAQFNLpyIHVLVNNA--YLGlirqaqrafDMDYCVQLafeninSPELNGYGVDHVKVAEGLGCKAIRVFKPEDI 531
                        570       580
                 ....*....|....*....|....*
gi 6320816   519 SRCFQQAVQLSRTKRETSVINVIIE 543
Cdd:PRK11269 532 APALEQAKALMAEFRVPVVVEVILE 556
PRK07710 PRK07710
acetolactate synthase large subunit;
2-473 1.19e-22

acetolactate synthase large subunit;


Pssm-ID: 236076 [Multi-domain]  Cd Length: 571  Bit Score: 101.76  E-value: 1.19e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     2 TTTATQHFAQLL----QKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGL 77
Cdd:PRK07710  11 TEEKLMTGAQMLiealEKEGVEVIFGYPGGAVLPLYDALYDCGIPHILTRHEQGAIHAAEGYARISGKPGVVIATSGPGA 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    78 IHALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKL-TPDNIDMITQKALNYCIQGTAGVSYI 156
Cdd:PRK07710  91 TNVVTGLADAMIDSLPLVVFTGQVATSVIGSDAFQEADIMGITMPVTKHNYQVrKASDLPRIIKEAFHIATTGRPGPVLI 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   157 DVPADFIEYEKPLEGNDRTgnELPMiLTPNIcGPDPSKIKKVVQLILQHKNKNILIVIGKGAVKNSHEIRRLVNTFNLPF 236
Cdd:PRK07710 171 DIPKDMVVEEGEFCYDVQM--DLPG-YQPNY-EPNLLQIRKLVQAVSVAKKPVILAGAGVLHAKASKELTSYAEQQEIPV 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   237 LPTPMAKGIVPDSSPLNV-------SSARSQALKIADIVLVLGARLNWILHfGTSPKWNSESIFIQFDSNPETLGDNNVS 309
Cdd:PRK07710 247 VHTLLGLGGFPADHPLFLgmagmhgTYTANMALYECDLLINIGARFDDRVT-GNLAYFAKEATVAHIDIDPAEIGKNVPT 325
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   310 pgaDLSIWGDIGLSVTALVEELTRQD--SCWKYsgvkqeirekiQLNQtrllRKEKTrgaQLNYNQVYGTLRP--LIDDY 385
Cdd:PRK07710 326 ---EIPIVADAKQALQVLLQQEGKKEnhHEWLS-----------LLKN----WKEKY---PLSYKRNSESIKPqkAIEML 384
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   386 RTILVTEGANTMDI------ARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETA 459
Cdd:PRK07710 385 YEITKGEAIVTTDVgqhqmwAAQYYPFKTPDKWVTSGGLGTMGFGLPAAIGAQLAKPDETVVAIVGDGGFQMTLQELSVI 464
                        490
                 ....*....|....
gi 6320816   460 VRCQLALVIVVMNN 473
Cdd:PRK07710 465 KELSLPVKVVILNN 478
PDC1 COG3961
TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase [Carbohydrate ...
1-544 7.93e-22

TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase [Carbohydrate transport and metabolism, Coenzyme transport and metabolism, General function prediction only]; TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 443161 [Multi-domain]  Cd Length: 545  Bit Score: 99.08  E-value: 7.93e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    1 MTTTATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVAN-GIKFIPCRNEQAasyaasaYGYISD-----KP-GVLLI-- 71
Cdd:COG3961   3 MTYTVGDYLLDRLAELGIRHIFGVPGDYNLPFLDAIEAHpGIRWVGCCNELN-------AGYAADgyarvNGlGALVTty 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   72 -VGGPGLIHALAGiynSMSNRWPLLVIAGSSSQSDIHKGG-------------FQELdqvsllspFLKFT---GKLTPDN 134
Cdd:COG3961  76 gVGELSAINGIAG---AYAERVPVVHIVGAPGTRAQRRGPllhhtlgdgdfdhFLRM--------FEEVTvaqAVLTPEN 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  135 IDMITQKALNYCIQGTAGVsYIDVPADFieYEKPLEgndRTGNELPMILTPnicgPDPSKIKKVVQLILQH--KNKNILI 212
Cdd:COG3961 145 AAAEIDRVLAAALREKRPV-YIELPRDV--ADAPIE---PPEAPLPLPPPA----SDPAALAAAVAAAAERlaKAKRPVI 214
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  213 VIGkgavknsHEIRR---------LVNTFNLPFLPTPMAKGIVPDSSPLNV---------SSARsQALKIADIVLVLGAR 274
Cdd:COG3961 215 LAG-------VEVHRfglqeellaLAEKTGIPVATTLLGKSVLDESHPQFIgtyagaassPEVR-EYVENADCVLCLGVV 286
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  275 LN-WILHFGTSpkwnsesifiQFDsnPE---TLGDNNVSPGAdlSIWGDIGLS--VTALVEELTRQDSCWKYSGVKQEir 348
Cdd:COG3961 287 FTdTNTGGFTA----------QLD--PErtiDIQPDSVRVGG--HIYPGVSLAdfLEALAELLKKRSAPLPAPAPPPP-- 350
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  349 ekiqlnqtrllRKEKTRGAQLNYNQVYGTLRPLIDDyRTILVTE------GANTMdiarisfptdaprrRLDAGTN---- 418
Cdd:COG3961 351 -----------PPPAAPDAPLTQDRLWQRLQAFLDP-GDIVVADtgtslfGAADL--------------RLPEGATfiaq 404
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  419 ---ATMGIG----LGYALACkashPELDVVLIQGDSAFGFSAMEIETAVRCQLALVIVVMNNSGiYHGEKDIEG------ 485
Cdd:COG3961 405 plwGSIGYTlpaaLGAALAA----PDRRVILLVGDGAFQLTAQELSTMLRYGLKPIIFVLNNDG-YTIERAIHGpdgpyn 479
                       570       580       590       600       610       620
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6320816  486 DLPptalskNCRYDLVGKGLGANDFF---VNTISELsrcfQQAVQLSRTKRET-SVINVIIEP 544
Cdd:COG3961 480 DIA------NWDYAKLPEAFGGGNALgfrVTTEGEL----EEALAAAEANTDRlTLIEVVLDK 532
TPP_enzyme_C pfam02775
Thiamine pyrophosphate enzyme, C-terminal TPP binding domain;
393-540 8.92e-22

Thiamine pyrophosphate enzyme, C-terminal TPP binding domain;


Pssm-ID: 460689 [Multi-domain]  Cd Length: 151  Bit Score: 91.88  E-value: 8.92e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    393 GANTMDIARIsFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVIVVMN 472
Cdd:pfam02775   3 GCHQMWAAQY-YRFRPPRRYLTSGGLGTMGYGLPAAIGAKLARPDRPVVAIAGDGGFQMNLQELATAVRYNLPITVVVLN 81
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6320816    473 NS--GIYHGEKDIEGDLPPTALS----KNCRYDLVGKGLGANDFFVNTISELSRCFQQAVQlsrtKRETSVINV 540
Cdd:pfam02775  82 NGgyGMTRGQQTPFGGGRYSGPSgkilPPVDFAKLAEAYGAKGARVESPEELEEALKEALE----HDGPALIDV 151
TPP_PYR_POX cd07039
Pyrimidine (PYR) binding domain of POX; Thiamine pyrophosphate (TPP family), pyrimidine (PYR) ...
4-162 1.32e-20

Pyrimidine (PYR) binding domain of POX; Thiamine pyrophosphate (TPP family), pyrimidine (PYR) binding domain of pyruvate oxidase (POX) subfamily. The PYR domain is found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. TPP binds in the cleft formed by a PYR domain and a PP domain. The PYR domain, binds the aminopyrimidine ring of TPP, the PP domain binds the diphosphate residue. The PYR and PP domains have a common fold, but do not share strong sequence conservation. The PP domain is not included in this sub-family. Most TPP-dependent enzymes have the PYR and PP domains on the same subunit although these domains can be alternatively arranged in the primary structure. TPP-dependent enzymes are multisubunit proteins, the smallest catalytic unit being a dimer-of-active sites. Lactobacillus plantarum POX is a homotetramer (dimer-of-homodimers), having two active sites per homodimer lying between PYR and PP domains of different subunits. POX decarboxylates pyruvate, producing hydrogen peroxide and the energy-storage metabolite acetylphosphate.


Pssm-ID: 132922 [Multi-domain]  Cd Length: 164  Bit Score: 88.76  E-value: 1.32e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    4 TATQHFAQLLQKYGIDTVFGIVGIPIVQLADTM-VANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALA 82
Cdd:cd07039   1 TVADVIVETLENWGVKRVYGIPGDSINGLMDALrREGKIEFIQVRHEEAAAFAASAEAKLTGKLGVCLGSSGPGAIHLLN 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   83 GIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKL-TPDNIDMITQKALNYCIqGTAGVSYIDVPAD 161
Cdd:cd07039  81 GLYDAKRDRAPVLAIAGQVPTDELGTDYFQEVDLLALFKDVAVYNETVtSPEQLPELLDRAIRTAI-AKRGVAVLILPGD 159

                .
gi 6320816  162 F 162
Cdd:cd07039 160 V 160
PRK07064 PRK07064
thiamine pyrophosphate-binding protein;
10-475 2.09e-20

thiamine pyrophosphate-binding protein;


Pssm-ID: 180820 [Multi-domain]  Cd Length: 544  Bit Score: 94.67  E-value: 2.09e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    10 AQLLQKYGIDTVFGIVGIPIVQLADTMVANG-IKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSM 88
Cdd:PRK07064  10 AAFLEQCGVKTAFGVISIHNMPILDAIGRRGkIRFVPARGEAGAVNMADAHARVSGGLGVALTSTGTGAGNAAGALVEAL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    89 SNRWPLLVIAGS-------SSQSDIHkggfQELDQVSllspFLKFTGK-----LTPDNIDMITQKALNYCIQGTAGVSYI 156
Cdd:PRK07064  90 TAGTPLLHITGQietpyldQDLGYIH----EAPDQLT----MLRAVSKaafrvRSAETALATIREAVRVALTAPTGPVSV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   157 DVPADfIEYEKplegndrtgNELPMILTP---NICGPDPSKIKKVVQLILQHKNKniLIVIGKGAVKNSHEIRRLVNtFN 233
Cdd:PRK07064 162 EIPID-IQAAE---------IELPDDLAPvhvAVPEPDAAAVAELAERLAAARRP--LLWLGGGARHAGAEVKRLVD-LG 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   234 LPFLPTPMAKGIVPDSSP-----LNVSSARSQALKIADIVLVLGARL------NWILHFGTSpkwnsesiFIQFDSNPET 302
Cdd:PRK07064 229 FGVVTSTQGRGVVPEDHPaslgaFNNSAAVEALYKTCDLLLVVGSRLrgnetlKYSLALPRP--------LIRVDADAAA 300
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   303 LGDNNVspgADLSIWGDIGLSVTALVEELtrqdscwkysgvkqEIREKIQLNQTRLLR--KEKTRGAQLNYNQVYGTlrp 380
Cdd:PRK07064 301 DGRGYP---NDLFVHGDAARVLARLADRL--------------EGRLSVDPAFAADLRaaREAAVADLRKGLGPYAK--- 360
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   381 LIDDYRTILVTEGANTMDIArIS--------FPTDAPRrrldAGTNATMG-IGLGYALACKAS--HPELDVVLIQGDSAF 449
Cdd:PRK07064 361 LVDALRAALPRDGNWVRDVT-ISnstwgnrlLPIFEPR----ANVHALGGgIGQGLAMAIGAAlaGPGRKTVGLVGDGGL 435
                        490       500
                 ....*....|....*....|....*.
gi 6320816   450 GFSAMEIETAVRCQLALVIVVMNNSG 475
Cdd:PRK07064 436 MLNLGELATAVQENANMVIVLMNDGG 461
PLN02470 PLN02470
acetolactate synthase
11-473 4.03e-20

acetolactate synthase


Pssm-ID: 215261 [Multi-domain]  Cd Length: 585  Bit Score: 94.03  E-value: 4.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    11 QLLQKYGIDTVFGIVGIPIVQLADTMV-ANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYNSMS 89
Cdd:PLN02470  21 EALEREGVDTVFAYPGGASMEIHQALTrSNCIRNVLCRHEQGEVFAAEGYAKASGKVGVCIATSGPGATNLVTGLADALL 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    90 NRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTG-KLTPDNIDMITQKALNYCIQGTAGVSYIDVPADFIE---- 164
Cdd:PLN02470 101 DSVPLVAITGQVPRRMIGTDAFQETPIVEVTRSITKHNYlVMDVEDIPRVIREAFFLASSGRPGPVLVDIPKDIQQqlav 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   165 --YEKPLEGNDRTgNELPMIltpnicgPDPSKIKKVVQLIlqHKNKNILIVIGKGAVKNSHEIRRLVNTFNLPFLPTPMA 242
Cdd:PLN02470 181 pnWNQPMKLPGYL-SRLPKP-------PEKSQLEQIVRLI--SESKRPVVYVGGGCLNSSEELREFVELTGIPVASTLMG 250
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   243 KGIVPDSSPLNVSS-------ARSQALKIADIVLVLGARLNWILHfGTSPKWNSESIFIQFDSNPETLGDNNvspGADLS 315
Cdd:PLN02470 251 LGAFPASDELSLQMlgmhgtvYANYAVDSADLLLAFGVRFDDRVT-GKLEAFASRASIVHIDIDPAEIGKNK---QPHVS 326
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   316 IWGDIGLSVTALVEEL-TRQDSCWKYSGVKQEIREKIQLNQTRLlrkeKTRGAQLNYNQVYGTLRPLIDDYRTILVTEGA 394
Cdd:PLN02470 327 VCADVKLALQGLNKLLeERKAKRPDFSAWRAELDEQKEKFPLSY----PTFGDAIPPQYAIQVLDELTDGNAIISTGVGQ 402
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6320816   395 NTMDIARIsFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVIVVMNN 473
Cdd:PLN02470 403 HQMWAAQW-YKYKEPRRWLTSGGLGAMGFGLPAAIGAAAANPDAIVVDIDGDGSFIMNIQELATIHVENLPVKIMVLNN 480
PRK08199 PRK08199
thiamine pyrophosphate protein; Validated
1-544 3.46e-19

thiamine pyrophosphate protein; Validated


Pssm-ID: 181285 [Multi-domain]  Cd Length: 557  Bit Score: 91.09  E-value: 3.46e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     1 MTTTATQHFAQLLQKYGIDTVFGIVG---IPIVQ-LADtmvANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPG 76
Cdd:PRK08199   6 RARTGGQILVDALRANGVERVFCVPGesyLAVLDaLHD---ETDIRVIVCRQEGGAAMMAEAYGKLTGRPGICFVTRGPG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    77 LIHALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSY 155
Cdd:PRK08199  83 ATNASIGVHTAFQDSTPMILFVGQVARDFREREAFQEIDYRRMFGPMAKWVAEIDdAARIPELVSRAFHVATSGRPGPVV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   156 IDVPADFieyekpLEGNDRTGNELPMilTPNICGPDPSKIKKVVQLILQHKnKNILIVIGKG----AVKnshEIRRLVNT 231
Cdd:PRK08199 163 LALPEDV------LSETAEVPDAPPY--RRVAAAPGAADLARLAELLARAE-RPLVILGGSGwteaAVA---DLRAFAER 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   232 FNLPFLPTPMAKGIVPDSSP-------LNVSSARSQALKIADIVLVLGARLNWILHFG----TSPKwnSESIFIQFDSNP 300
Cdd:PRK08199 231 WGLPVACAFRRQDLFDNRHPnyagdlgLGINPALAARIREADLVLAVGTRLGEVTTQGytllDIPV--PRQTLVHVHPDA 308
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   301 ETLGdnNVSPgADLSIWGDIGLSVTALVEELTRQDSCWKysGVKQEIREKIQLNQTRLLrkekTRGAqLNYNQVYGTLRP 380
Cdd:PRK08199 309 EELG--RVYR-PDLAIVADPAAFAAALAALEPPASPAWA--EWTAAAHADYLAWSAPLP----GPGA-VQLGEVMAWLRE 378
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   381 -LIDDyrTIlVTEGA-NTMDIARISFPTDAPRRRLdAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIET 458
Cdd:PRK08199 379 rLPAD--AI-ITNGAgNYATWLHRFFRFRRYRTQL-APTSGSMGYGLPAAIAAKLLFPERTVVAFAGDGCFLMNGQELAT 454
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   459 AVRCQLALVIVVMNNsGIY-----HGEKDIEGDLPPTALsKNCRYDLVGKGLGANDFFVNTISElsrcFQQAVQLSRTKR 533
Cdd:PRK08199 455 AVQYGLPIIVIVVNN-GMYgtirmHQEREYPGRVSGTDL-TNPDFAALARAYGGHGETVERTED----FAPAFERALASG 528
                        570
                 ....*....|.
gi 6320816   534 ETSVINVIIEP 544
Cdd:PRK08199 529 KPALIEIRIDP 539
TPP_POX cd02014
Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; ...
369-546 6.57e-18

Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates pyruvate, producing hydrogen peroxide and the energy-storage metabolite acetylphosphate. It requires FAD in addition to TPP and a divalent cation as cofactors.


Pssm-ID: 238972 [Multi-domain]  Cd Length: 178  Bit Score: 81.42  E-value: 6.57e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  369 LNYNQVYGTLRPLIDDyRTILVTE-GANTMDIARiSFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDS 447
Cdd:cd02014   2 IHPERVAAELNKRAPD-DAIFTIDvGNVTVWAAR-HLRMNGKQRFILSGLLATMGNGLPGAIAAKLAYPDRQVIALSGDG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  448 AFGFSAMEIETAVRCQLALVIVVMNNS--GIYHGEKDIEGDLP-PTALSkNCRYDLVGKGLGANDFFVNTISELSRCFQQ 524
Cdd:cd02014  80 GFAMLMGDLITAVKYNLPVIVVVFNNSdlGFIKWEQEVMGQPEfGVDLP-NPDFAKIAEAMGIKGIRVEDPDELEAALDE 158
                       170       180
                ....*....|....*....|..
gi 6320816  525 AVQLSRtkreTSVINVIIEPGE 546
Cdd:cd02014 159 ALAADG----PVVIDVVTDPNE 176
TPP_Xsc_like cd02013
Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of ...
366-545 3.49e-17

Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the desulfonation of 2-sulfoacetaldehyde into sulfite and acetyl phosphate. This enzyme requires TPP and divalent metal ions for activity.


Pssm-ID: 238971 [Multi-domain]  Cd Length: 196  Bit Score: 79.86  E-value: 3.49e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  366 GAQLNYNQVYGTLRPLIDDyRTILVTEGANTMDIARISFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQG 445
Cdd:cd02013   1 GNPMHPRQVLRELEKAMPE-DAIVSTDIGNICSVANSYLRFEKPRSFIAPLSFGNCGYALPAIIGAKAAAPDRPVVAIAG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  446 DSAFGFSAMEIETAVRCQLALVIVVMNNSG---------IYHGEKDIEGDLPPTalskncRYDLVGKGLGANDFFVNTIS 516
Cdd:cd02013  80 DGAWGMSMMEIMTAVRHKLPVTAVVFRNRQwgaekknqvDFYNNRFVGTELESE------SFAKIAEACGAKGITVDKPE 153
                       170       180
                ....*....|....*....|....*....
gi 6320816  517 ELSRCFQQAVQLsRTKRETSVINVIIEPG 545
Cdd:cd02013 154 DVGPALQKAIAM-MAEGKTTVIEIVCDQE 181
TPP_ALS cd02010
Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; ...
378-475 2.81e-16

Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2 molecules of pyruvate to acetolactate and carbon dioxide. ALS does not contain FAD, and requires TPP and a divalent metal cation for activity.


Pssm-ID: 238968 [Multi-domain]  Cd Length: 177  Bit Score: 76.94  E-value: 2.81e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  378 LRPLIDDYRTILVTEGANTMDIARIsFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIE 457
Cdd:cd02010   8 LRAVMGDDDIVLLDVGAHKIWMARY-YRTYAPNTCLISNGLATMGVALPGAIGAKLVYPDRKVVAVSGDGGFMMNSQELE 86
                        90
                ....*....|....*...
gi 6320816  458 TAVRCQLALVIVVMNNSG 475
Cdd:cd02010  87 TAVRLKIPLVVLIWNDNG 104
PRK08978 PRK08978
acetolactate synthase 2 catalytic subunit; Reviewed
7-474 1.85e-15

acetolactate synthase 2 catalytic subunit; Reviewed


Pssm-ID: 181601 [Multi-domain]  Cd Length: 548  Bit Score: 79.15  E-value: 1.85e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     7 QHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIHALAGIYN 86
Cdd:PRK08978   5 QWVVHALRAQGVDTVFGYPGGAIMPVYDALYDGGVEHLLCRHEQGAAMAAIGYARATGKVGVCIATSGPGATNLITGLAD 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    87 SMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYIDVPADFIEY 165
Cdd:PRK08978  85 ALLDSVPVVAITGQVSSPLIGTDAFQEIDVLGLSLACTKHSFLVQsLEELPEIMAEAFEIASSGRPGPVLVDIPKDIQLA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   166 EKPLEGNDRTGNELPMiltpnicgPDPSKIKKVVQLILQHKnKNILIVIG----KGAVknsHEIRRLVNTFNLPFLPTPM 241
Cdd:PRK08978 165 EGELEPHLTTVENEPA--------FPAAELEQARALLAQAK-KPVLYVGGgvgmAGAV---PALREFLAATGMPAVATLK 232
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   242 AKGIVPDSSPLNV-------SSARSQALKIADIVLVLGAR--------LNwilHFGTSPKwnsesiFIQFDSNPETLGDN 306
Cdd:PRK08978 233 GLGAVEADHPYYLgmlgmhgTKAANLAVQECDLLIAVGARfddrvtgkLN---TFAPHAK------VIHLDIDPAEINKL 303
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   307 NVspgADLSIWGDIGLSVTALVEELT-----------RQDSCWKYSGVKQEIREKIQLNQtrlLRKEKTrgaqlnynqvy 375
Cdd:PRK08978 304 RQ---AHVALQGDLNALLPALQQPLNidawrqhcaqlRAEHAWRYDHPGEAIYAPALLKQ---LSDRKP----------- 366
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   376 gtlrpliddYRTILVTE-GANTMDIAR-ISFptDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSA 453
Cdd:PRK08978 367 ---------ADTVVTTDvGQHQMWVAQhMRF--TRPENFITSSGLGTMGFGLPAAIGAQVARPDDTVICVSGDGSFMMNV 435
                        490       500
                 ....*....|....*....|.
gi 6320816   454 MEIETAVRCQLALVIVVMNNS 474
Cdd:PRK08978 436 QELGTIKRKQLPVKIVLLDNQ 456
PRK09124 PRK09124
ubiquinone-dependent pyruvate dehydrogenase;
1-474 4.27e-14

ubiquinone-dependent pyruvate dehydrogenase;


Pssm-ID: 181661 [Multi-domain]  Cd Length: 574  Bit Score: 75.02  E-value: 4.27e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     1 MTTTATQHFAQLLQKYGIDTVFGIVGIPIVQLADTMVANG-IKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLIH 79
Cdd:PRK09124   1 MKQTVADYIAKTLEQAGVKRIWGVTGDSLNGLSDSLRRMGtIEWMHTRHEEVAAFAAGAEAQLTGELAVCAGSCGPGNLH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    80 ALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLL---SPFLKFTGklTPDNIDMITQKALNYCIqGTAGVSYI 156
Cdd:PRK09124  81 LINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQELFrecSHYCELVS--NPEQLPRVLAIAMRKAI-LNRGVAVV 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   157 DVPADFIEYEKPLEGNDR-TGNELPMILtpnicgPDPSKIKKVVQLIlqHKNKNILIVIGKGAVKNSHEIRRLVNTFNLP 235
Cdd:PRK09124 158 VLPGDVALKPAPERATPHwYHAPQPVVT------PAEEELRKLAALL--NGSSNITLLCGSGCAGAHDELVALAETLKAP 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   236 FLPTPMAKGIVPDSSPLNVS-------SARSQALKIADIVLVLGARlnwilhFGTSPKWNSESIFIQFDSNPETLGDNnv 308
Cdd:PRK09124 230 IVHALRGKEHVEYDNPYDVGmtgligfSSGYHAMMNCDTLLMLGTD------FPYRQFYPTDAKIIQIDINPGSLGRR-- 301
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   309 SPgADLSIWGDIGLSVTALVEELTRQDScwkysgvkQEIREKiQLNQTRLLRKEKTRGAQLNYNQvygtlRPLIDDYRTI 388
Cdd:PRK09124 302 SP-VDLGLVGDVKATLAALLPLLEEKTD--------RKFLDK-ALEHYRKARKGLDDLAVPSDGG-----KPIHPQYLAR 366
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   389 LVTEGANtmDIARISFPTDAP------------RRRLDAGTN-ATMGIGLGYALACKASHPELDVVLIQGDSafGFSAM- 454
Cdd:PRK09124 367 QISEFAA--DDAIFTCDVGTPtvwaarylkmngKRRLLGSFNhGSMANAMPQALGAQAAHPGRQVVALSGDG--GFSMLm 442
                        490       500
                 ....*....|....*....|.
gi 6320816   455 -EIETAVRCQLALVIVVMNNS 474
Cdd:PRK09124 443 gDFLSLVQLKLPVKIVVFNNS 463
TPP_AHAS cd02015
Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding ...
373-546 1.25e-13

Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the acetohydroxyacid, 2-acetolactate. 2-Acetolactate is the precursor of the branched chain amino acids, valine and leucine. AHAS also catalyzes the condensation of pyruvate and 2-ketobutyrate to form 2-aceto-2-hydroxybutyrate in isoleucine biosynthesis. In addition to requiring TPP and a divalent metal ion as cofactors, AHAS requires FAD.


Pssm-ID: 238973 [Multi-domain]  Cd Length: 186  Bit Score: 69.45  E-value: 1.25e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  373 QVYGTLRPLIDDyRTILVTE-GANTMDIARiSFPTDAPRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGF 451
Cdd:cd02015   5 EVIKELSELTPG-DAIVTTDvGQHQMWAAQ-YYRFKKPRSWLTSGGLGTMGFGLPAAIGAKVARPDKTVICIDGDGSFQM 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  452 SAMEIETAVRCQLALVIVVMNNSG---------IYHGEKDIEgdlppTALSKNCRYDLVGKGLGANDFFVNTISELSRCF 522
Cdd:cd02015  83 NIQELATAAQYNLPVKIVILNNGSlgmvrqwqeLFYEGRYSH-----TTLDSNPDFVKLAEAYGIKGLRVEKPEELEAAL 157
                       170       180
                ....*....|....*....|....
gi 6320816  523 QQAVQlsrtKRETSVINVIIEPGE 546
Cdd:cd02015 158 KEALA----SDGPVLLDVLVDPEE 177
PRK06546 PRK06546
pyruvate dehydrogenase; Provisional
1-474 1.32e-12

pyruvate dehydrogenase; Provisional


Pssm-ID: 180614 [Multi-domain]  Cd Length: 578  Bit Score: 70.40  E-value: 1.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     1 MTTTATQhFAQLLQKYGIDTVFGIVGI---PIVQLADTmvANGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGL 77
Cdd:PRK06546   2 AKTVAEQ-LVEQLVAAGVKRIYGIVGDslnPIVDAVRR--TGGIEWVHVRHEEAAAFAAAAEAQLTGKLAVCAGSCGPGN 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    78 IHALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDqvsllspflkftgkltPDNI--------DMITQKA-----LN 144
Cdd:PRK06546  79 LHLINGLYDAHRSGAPVLAIASHIPSAQIGSGFFQETH----------------PDRLfvecsgycEMVSSAEqaprvLH 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   145 YCIQ---GTAGVSYIDVPADFIEYEKPlegndRTGNELPMILTPNICGPDPSKIKKVVQLIlqHKNKNILIVIGKGaVKN 221
Cdd:PRK06546 143 SAIQhavAGGGVSVVTLPGDIADEPAP-----EGFAPSVISPRRPTVVPDPAEVRALADAI--NEAKKVTLFAGAG-VRG 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   222 SH-EIRRLVNTFNLPFLPTPMAKGIVPDSSPLNVS-------SARSQALKIADIVLVLGARL--NWILhfgtsPKWNSes 291
Cdd:PRK06546 215 AHaEVLALAEKIKAPVGHSLRGKEWIQYDNPFDVGmsgllgyGAAHEAMHEADLLILLGTDFpyDQFL-----PDVRT-- 287
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   292 ifIQFDSNPETLGDNNvspGADLSIWGDIGLSVTALVEELTRQDScwkysgvkQEIREKIQLNQTRLLrkEKTRGAqlnY 371
Cdd:PRK06546 288 --AQVDIDPEHLGRRT---RVDLAVHGDVAETIRALLPLVKEKTD--------RRFLDRMLKKHARKL--EKVVGA---Y 349
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   372 NQVYGTLRPLIDDYRTILVTEGAN-----TMDI-------ARisFPTDAPRRR-LDAGTNATMGIGLGYALACKASHPEL 438
Cdd:PRK06546 350 TRKVEKHTPIHPEYVASILDELAAddavfTVDTgmcnvwaAR--YITPNGRRRvIGSFRHGSMANALPHAIGAQLADPGR 427
                        490       500       510
                 ....*....|....*....|....*....|....*.
gi 6320816   439 DVVLIQGDSAFGFSAMEIETAVRCQLALVIVVMNNS 474
Cdd:PRK06546 428 QVISMSGDGGLSMLLGELLTVKLYDLPVKVVVFNNS 463
TPP_PDC_IPDC cd02005
Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of ...
420-546 5.72e-10

Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of pyruvate to acetaldehyde and CO2. It is able to utilize other 2-oxo acids as substrates. In plants and various plant-associated bacteria, IPDC plays a role in the indole-3-pyruvic acid (IPA) pathway, a tryptophan-dependent biosynthetic route to indole-3-acetaldehyde (IAA). IPDC catalyzes the decarboxylation of IPA to IAA. Both PDC and IPDC depend on TPP and Mg2+ as cofactors.


Pssm-ID: 238963 [Multi-domain]  Cd Length: 183  Bit Score: 58.70  E-value: 5.72e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  420 TMGIGLGYALAckasHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVIVVMNNSGiYHGEKDIEGDLPPTALSKNCRYD 499
Cdd:cd02005  55 SVPAALGAALA----APDRRVILLVGDGSFQMTVQELSTMIRYGLNPIIFLINNDG-YTIERAIHGPEASYNDIANWNYT 129
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 6320816  500 LVGKGLGAND----FFVNTISELsrcfQQAVQLSRTKRET-SVINVIIEPGE 546
Cdd:cd02005 130 KLPEVFGGGGgglsFRVKTEGEL----DEALKDALFNRDKlSLIEVILPKDD 177
TPP_IolD cd02003
Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins ...
371-544 1.89e-09

Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism.


Pssm-ID: 238961 [Multi-domain]  Cd Length: 205  Bit Score: 57.70  E-value: 1.89e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  371 YNQVYGTLRPLIDDYRTILVTEGANTMDIARIsFPTDAPRR-RLDAGTnATMGIGLGYALACKASHPELDVVLIQGDSAF 449
Cdd:cd02003   1 QTEVLGALNEAIGDDDVVINAAGSLPGDLHKL-WRARTPGGyHLEYGY-SCMGYEIAAGLGAKLAKPDREVYVLVGDGSY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  450 GFSAMEIETAVRCQLALVIVVMNNSGiY-----------------------HGEKDIEGDLPPTALSKNCRydlvgkGLG 506
Cdd:cd02003  79 LMLHSEIVTAVQEGLKIIIVLFDNHG-FgcinnlqestgsgsfgtefrdrdQESGQLDGALLPVDFAANAR------SLG 151
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 6320816  507 ANDFFVNTISElsrcFQQAVQLSRTKRETSVINVIIEP 544
Cdd:cd02003 152 ARVEKVKTIEE----LKAALAKAKASDRTTVIVIKTDP 185
PRK08273 PRK08273
thiamine pyrophosphate protein; Provisional
1-473 2.77e-09

thiamine pyrophosphate protein; Provisional


Pssm-ID: 181344 [Multi-domain]  Cd Length: 597  Bit Score: 59.92  E-value: 2.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     1 MTTTATQHFAQLLQKYGIDTVFGIVGIPIVQLadtMVA-----NGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGP 75
Cdd:PRK08273   1 MSQTVADFILERLREWGVRRVFGYPGDGINGL---LGAlgradDKPEFVQARHEEMAAFMAVAHAKFTGEVGVCLATSGP 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    76 GLIHALAGIYNSMSNRWPLLVIAGSSSQSDIhkGGF--QELDQVSLL----SPFLKFTgkLTPDNIDMITQKALNYCIqG 149
Cdd:PRK08273  78 GAIHLLNGLYDAKLDHVPVVAIVGQQARAAL--GGHyqQEVDLQSLFkdvaGAFVQMV--TVPEQLRHLVDRAVRTAL-A 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   150 TAGVSYIDVPADF--IEYEKPLE--GNDRTGnelPMILTPNICgPDPSKIKKVVQLIlqHKNKNILIVIGKGAVKNSHEI 225
Cdd:PRK08273 153 ERTVTAVILPNDVqeLEYEPPPHahGTVHSG---VGYTRPRVV-PYDEDLRRAAEVL--NAGRKVAILVGAGALGATDEV 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   226 RRLVNTFNLPFLPTPMAKGIVPDSSPlnvssarsqalkiadivLVLGArlnwILHFGTSPKWN----------------- 288
Cdd:PRK08273 227 IAVAERLGAGVAKALLGKAALPDDLP-----------------WVTGS----IGLLGTKPSYElmrecdtllmvgssfpy 285
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   289 SEsiF---------IQFDSNPETLGdnNVSPgADLSIWGDIGLSVTALVEELTR-QDSCWkysgvkqeiREKIQLNQTR- 357
Cdd:PRK08273 286 SE--FlpkegqargVQIDIDGRMLG--LRYP-MEVNLVGDAAETLRALLPLLERkKDRSW---------RERIEKWVARw 351
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816   358 --LLRKEKTRGAQ-LNYNQVYGTLRPLIDDyRTILVTE-GANTMDIAR-ISFptdapRRRLDA---GTNATMGIGLGYAL 429
Cdd:PRK08273 352 weTLEARAMVPADpVNPQRVFWELSPRLPD-NAILTADsGSCANWYARdLRM-----RRGMMAslsGTLATMGPAVPYAI 425
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|
gi 6320816   430 ACKASHPELDVVLIQGDSAFGFSAM-EIETAVRC--QLA---LVIVVMNN 473
Cdd:PRK08273 426 AAKFAHPDRPVIALVGDGAMQMNGMaELITVAKYwrQWSdprLIVLVLNN 475
TPP_BFDC cd02002
Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins ...
377-542 3.63e-09

Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of benzoylformate to benzaldehyde and carbon dioxide. This enzyme is dependent on TPP and a divalent metal cation as cofactors.


Pssm-ID: 238960 [Multi-domain]  Cd Length: 178  Bit Score: 56.45  E-value: 3.63e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  377 TLRPLIDDyRTILVTEGANTMDIARISFPTDAPRRRLdagTNATMGIG------LGYALACkashPELDVVLIQGDSAFG 450
Cdd:cd02002   9 ALAAALPE-DAIIVDEAVTNGLPLRDQLPLTRPGSYF---TLRGGGLGwglpaaVGAALAN----PDRKVVAIIGDGSFM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  451 FSAMEIETAVRCQLALVIVVMNNSG----------IYHGEKDIEGDLPPTALSKNCRYDLVGKGLGANDFFVNTISELSR 520
Cdd:cd02002  81 YTIQALWTAARYGLPVTVVILNNRGygalrsflkrVGPEGPGENAPDGLDLLDPGIDFAAIAKAFGVEAERVETPEELDE 160
                       170       180
                ....*....|....*....|..
gi 6320816  521 CFQQAVqlsrTKRETSVINVII 542
Cdd:cd02002 161 ALREAL----AEGGPALIEVVV 178
TPP_enzyme_PYR cd06586
Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Thiamine ...
9-160 4.35e-07

Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Thiamine pyrophosphate (TPP) family, pyrimidine (PYR) binding domain; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. TPP binds in the cleft formed by a PYR domain and a PP domain. The PYR domain, binds the aminopyrimidine ring of TPP, the PP domain binds the diphosphate residue. A polar interaction between the conserved glutamate of the PYR domain and the N1' of the TPP aminopyrimidine ring is shared by most TPP-dependent enzymes, and participates in the activation of TPP. The PYR and PP domains have a common fold, but do not share strong sequence conservation. The PP domain is not included in this group. Most TPP-dependent enzymes have the PYR and PP domains on the same subunit although these domains can be alternatively arranged in the primary structure. In the case of 2-oxoisovalerate dehydrogenase (2OXO), sulfopyruvate decarboxylase (ComDE), and the E1 component of human pyruvate dehydrogenase complex (E1- PDHc) the PYR and PP domains appear on different subunits. TPP-dependent enzymes are multisubunit proteins, the smallest catalytic unit being a dimer-of-active sites. For many of these enzymes the active sites lie between PP and PYR domains on different subunits. However, for the homodimeric enzymes 1-deoxy-D-xylulose 5-phosphate synthase (DXS) and Desulfovibrio africanus pyruvate:ferredoxin oxidoreductase (PFOR), each active site lies at the interface of the PYR and PP domains from the same subunit.


Pssm-ID: 132915 [Multi-domain]  Cd Length: 154  Bit Score: 49.65  E-value: 4.35e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    9 FAQLLQKYGIDTVFGIVGIPIVQLADTMVAN-GIKFIPCRNEQAASYAASayGY-ISDKPGVLLIVGGPGLIHALAGIYN 86
Cdd:cd06586   3 FAEVLTAWGVRHVFGYPGDEISSLLDALREGdKRIIDTVIHELGAAGAAA--GYaRAGGPPVVIVTSGTGLLNAINGLAD 80
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6320816   87 SMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLTPDNIDMitqKALNYCIQ---GTAGVSYIDVPA 160
Cdd:cd06586  81 AAAEHLPVVFLIGARGISAQAKQTFQSMFDLGMYRSIPEANISSPSPAELP---AGIDHAIRtayASQGPVVVRLPR 154
TPP_PYR_PDC_IPDC_like cd07038
Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase ...
7-109 1.57e-05

Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Thiamine pyrophosphate (TPP family), pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC) subfamily. The PYR domain is found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. TPP binds in the cleft formed by a PYR domain and a PP domain. The PYR domain, binds the aminopyrimidine ring of TPP, the PP domain binds the diphosphate residue. The PYR and PP domains have a common fold, but do not share strong sequence conservation. The PP domain is not included in this sub-family. Most TPP-dependent enzymes have the PYR and PP domains on the same subunit although these domains can be alternatively arranged in the primary structure. TPP-dependent enzymes are multisubunit proteins, the smallest catalytic unit being a dimer-of-active sites, for many the active sites lie between PP and PYR domains on different subunits. PDC catalyzes the conversion of pyruvate to acetaldehyde and CO2 in alcoholic fermentation. IPDC plays a role in the indole-3-pyruvic acid (IPA) pathway in plants and various plant-associated bacteria, it catalyzes the decarboxylation of IPA to IAA. Also belonging to this group is Mycobacterium tuberculosis alpha-keto acid decarboxylase (MtKDC) which participates in amino acid degradation via the Ehrlich pathway, and Lactococcus lactis branched-chain keto acid decarboxylase (KdcA) an enzyme identified as being involved in cheese ripening, which exhibits a very broad substrate range in the decarboxylation and carboligation reactions.


Pssm-ID: 132921 [Multi-domain]  Cd Length: 162  Bit Score: 45.18  E-value: 1.57e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    7 QHFAQLLQKYGIDTVFGIVGIPIVQLADTMVAN-GIKFIPCRNEQAasyaasaYGYISD------KPGVLLIVGGPGLIH 79
Cdd:cd07038   1 EYLLERLKQLGVKHVFGVPGDYNLPLLDAIEENpGLRWVGNCNELN-------AGYAADgyarvkGLGALVTTYGVGELS 73
                        90       100       110
                ....*....|....*....|....*....|
gi 6320816   80 ALAGIYNSMSNRWPLLVIAGSSSQSDIHKG 109
Cdd:cd07038  74 ALNGIAGAYAEHVPVVHIVGAPSTKAQASG 103
TPP_Gcl cd02006
Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins ...
409-543 4.94e-05

Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the condensation of two molecules of glyoxylate to give tartronic semialdehyde and carbon dioxide. This enzyme requires TPP, magnesium ion and FAD as cofactors.


Pssm-ID: 238964 [Multi-domain]  Cd Length: 202  Bit Score: 44.58  E-value: 4.94e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  409 PRRRLDAGTNATMGIGLGYALACKASHPELDVVLIQGDSAFGFSAMEIETAVRCQLALVIVVMNNSG---IYHGEKDIEG 485
Cdd:cd02006  47 PRHWINCGQAGPLGWTVPAALGVAAADPDRQVVALSGDYDFQFMIEELAVGAQHRIPYIHVLVNNAYlglIRQAQRAFDM 126
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6320816  486 DLPPTALSKNCR------YDL----VGKGLGANDFFVNTISELSRCFQQAVQLSRTKRETSVINVIIE 543
Cdd:cd02006 127 DYQVNLAFENINsselggYGVdhvkVAEGLGCKAIRVTKPEELAAAFEQAKKLMAEHRVPVVVEAILE 194
TPP_ComE cd03372
Thiamine pyrophosphate (TPP) family, ComE subfamily, TPP-binding module; composed of proteins ...
420-548 7.33e-04

Thiamine pyrophosphate (TPP) family, ComE subfamily, TPP-binding module; composed of proteins similar to Methanococcus jannaschii sulfopyruvate decarboxylase beta subunit (ComE). M. jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six alpha (D) subunits and six (E) beta subunits, which catalyzes the decarboxylation of sulfopyruvic acid to sulfoacetaldehyde in the coenzyme M pathway. ComDE requires TPP and divalent metal cation cofactors.


Pssm-ID: 239469 [Multi-domain]  Cd Length: 179  Bit Score: 40.73  E-value: 7.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816  420 TMG----IGLGYALACkashpELDVVLIQGDSAF--GFSAMeIETAVRCQLALVIVVMNNsGIYhGEKdieGDlPPTALS 493
Cdd:cd03372  43 SMGlassIGLGLALAQ-----PRKVIVIDGDGSLlmNLGAL-ATIAAEKPKNLIIVVLDN-GAY-GST---GN-QPTHAG 110
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6320816  494 KNCRYDLVGKGLGANDF-FVNTISELSRCFQQAvqlsrtKRETSVINVIIEPGEQK 548
Cdd:cd03372 111 KKTDLEAVAKACGLDNVaTVASEEAFEKAVEQA------LDGPSFIHVKIKPGNTD 160
PRK12474 PRK12474
hypothetical protein; Provisional
2-161 8.33e-03

hypothetical protein; Provisional


Pssm-ID: 139002 [Multi-domain]  Cd Length: 518  Bit Score: 39.09  E-value: 8.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816     2 TTTATQHFAQLLQKYGIDTVFGIVG---IPIVQLADTMvaNGIKFIPCRNEQAASYAASAYGYISDKPGVLLIVGGPGLI 78
Cdd:PRK12474   4 TMNGADSVVDTLLNCGVEVCFANPGtseMHFVAALDRV--PRMRPVLCLFEGVVTGAADGYGRIAGKPAVTLLHLGPGLA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320816    79 HALAGIYNSMSNRWPLLVIAGSSSQSDIHKGGFQELDQVSLLSPFLKFTGKLT-PDNIDMITQKALNYCIQGTAGVSYID 157
Cdd:PRK12474  82 NGLANLHNARRAASPIVNIVGDHAVEHLQYDAPLTSDIDGFARPVSRWVHRSAsAGAVDSDVARAVQAAQSAPGGIATLI 161

                 ....
gi 6320816   158 VPAD 161
Cdd:PRK12474 162 MPAD 165
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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