NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|6321304|ref|NP_011381|]
View 

Pcl10p [Saccharomyces cerevisiae S288C]

Protein Classification

cyclin family protein( domain architecture ID 15334629)

cyclin family protein may associate with and activate its cognate cyclin-dependent kinase (CDK); similar to Saccharomyces cerevisiae PHO85 cyclin-10 and Neurospora crassa Nuc-1 negative regulatory protein preg

CATH:  1.10.472.10
Gene Ontology:  GO:0000079|GO:0019901
PubMed:  30185601
SCOP:  4001102

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CYCLIN_ScPCL7-like cd20558
cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins; ...
 306-412 2.96e-32

cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins; ScPCL7, also called PHO85-associated protein 1, is a cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL6, ScPCL7 controls glycogen phosphorylase and glycogen synthase activities in response to nutrient availablility. This family also includes Schizosaccharomyces pombe PHO85 cyclin-like protein Psl1 (SpPsl1) and Arabidopsis thaliana PHO80-like proteins, P-type cyclins (CYCPs). SpPsl1 is the cyclin partner of the CDK pef1 (PHO85 homolog). CYCPs may be involved in cell division, cell differentiation, and the nutritional status of the cell in Arabidopsis thaliana. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


:

Pssm-ID: 410261  Cd Length: 101  Bit Score: 118.04  E-value: 2.96e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321304  306 PTLSSADFLKRIQDKCEYQPTVYLVATFLIDTLFLTRDGnnilqlkLNLQEKEVHRMIIAAVRLSTKLLEDFVHSHEYFS 385
Cdd:cd20558   1 PSISILDYLERIVKYCPCSPECFLLALIYIDRLIATING-------FVVTSLNVHRLLITALTLAAKFLDDRYYSNAYYA 73

                        90       100
                ....*....|....*....|....*..
gi 6321304  386 KVCGISKRLLTKLEVSLLICVCNTKLM 412
Cdd:cd20558  74 KVGGVSVSELNKLELEFLFLLDFDLHV 100
 
Name Accession Description Interval E-value
CYCLIN_ScPCL7-like cd20558
cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins; ...
 306-412 2.96e-32

cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins; ScPCL7, also called PHO85-associated protein 1, is a cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL6, ScPCL7 controls glycogen phosphorylase and glycogen synthase activities in response to nutrient availablility. This family also includes Schizosaccharomyces pombe PHO85 cyclin-like protein Psl1 (SpPsl1) and Arabidopsis thaliana PHO80-like proteins, P-type cyclins (CYCPs). SpPsl1 is the cyclin partner of the CDK pef1 (PHO85 homolog). CYCPs may be involved in cell division, cell differentiation, and the nutritional status of the cell in Arabidopsis thaliana. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410261  Cd Length: 101  Bit Score: 118.04  E-value: 2.96e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321304  306 PTLSSADFLKRIQDKCEYQPTVYLVATFLIDTLFLTRDGnnilqlkLNLQEKEVHRMIIAAVRLSTKLLEDFVHSHEYFS 385
Cdd:cd20558   1 PSISILDYLERIVKYCPCSPECFLLALIYIDRLIATING-------FVVTSLNVHRLLITALTLAAKFLDDRYYSNAYYA 73

                        90       100
                ....*....|....*....|....*..
gi 6321304  386 KVCGISKRLLTKLEVSLLICVCNTKLM 412
Cdd:cd20558  74 KVGGVSVSELNKLELEFLFLLDFDLHV 100
Cyclin pfam08613
Cyclin; This family includes many different cyclin proteins. Members include the G1/S-specific ...
 298-406 1.01e-15

Cyclin; This family includes many different cyclin proteins. Members include the G1/S-specific cyclin pas1, and the phosphate system cyclin PHO80/PHO85.


Pssm-ID: 400780  Cd Length: 149  Bit Score: 74.02  E-value: 1.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321304    298 SNFYMKSKPTLSSADFLKRIQDKCEYQPTVYLVATFLIDTLFLTRDGNNILQLKLNlqekeVHRMIIAAVRLSTKLLEDF 377
Cdd:pfam08613  42 LSFYSKAVPAISIGAYLSRIQKFCPSSPAVLLSALIYLDRLVKRCDSEAFVVTSAN-----AHRLLITAVTVATKFLSDG 116

                          90       100
                  ....*....|....*....|....*....
gi 6321304    378 VHSHEYFSKVCGISKRLLTKLEVSLLICV 406
Cdd:pfam08613 117 FYSNSRFAKVGGISLHELNHLEIDFLFLV 145
 
Name Accession Description Interval E-value
CYCLIN_ScPCL7-like cd20558
cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins; ...
 306-412 2.96e-32

cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins; ScPCL7, also called PHO85-associated protein 1, is a cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL6, ScPCL7 controls glycogen phosphorylase and glycogen synthase activities in response to nutrient availablility. This family also includes Schizosaccharomyces pombe PHO85 cyclin-like protein Psl1 (SpPsl1) and Arabidopsis thaliana PHO80-like proteins, P-type cyclins (CYCPs). SpPsl1 is the cyclin partner of the CDK pef1 (PHO85 homolog). CYCPs may be involved in cell division, cell differentiation, and the nutritional status of the cell in Arabidopsis thaliana. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410261  Cd Length: 101  Bit Score: 118.04  E-value: 2.96e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321304  306 PTLSSADFLKRIQDKCEYQPTVYLVATFLIDTLFLTRDGnnilqlkLNLQEKEVHRMIIAAVRLSTKLLEDFVHSHEYFS 385
Cdd:cd20558   1 PSISILDYLERIVKYCPCSPECFLLALIYIDRLIATING-------FVVTSLNVHRLLITALTLAAKFLDDRYYSNAYYA 73

                        90       100
                ....*....|....*....|....*..
gi 6321304  386 KVCGISKRLLTKLEVSLLICVCNTKLM 412
Cdd:cd20558  74 KVGGVSVSELNKLELEFLFLLDFDLHV 100
Cyclin pfam08613
Cyclin; This family includes many different cyclin proteins. Members include the G1/S-specific ...
 298-406 1.01e-15

Cyclin; This family includes many different cyclin proteins. Members include the G1/S-specific cyclin pas1, and the phosphate system cyclin PHO80/PHO85.


Pssm-ID: 400780  Cd Length: 149  Bit Score: 74.02  E-value: 1.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321304    298 SNFYMKSKPTLSSADFLKRIQDKCEYQPTVYLVATFLIDTLFLTRDGNNILQLKLNlqekeVHRMIIAAVRLSTKLLEDF 377
Cdd:pfam08613  42 LSFYSKAVPAISIGAYLSRIQKFCPSSPAVLLSALIYLDRLVKRCDSEAFVVTSAN-----AHRLLITAVTVATKFLSDG 116

                          90       100
                  ....*....|....*....|....*....
gi 6321304    378 VHSHEYFSKVCGISKRLLTKLEVSLLICV 406
Cdd:pfam08613 117 FYSNSRFAKVGGISLHELNHLEIDFLFLV 145
CYCLIN_AtCycU-like cd20604
cyclin box found in Arabidopsis thaliana U-type cyclins (CycUs) and similar proteins; CycUs ...
 300-403 2.64e-11

cyclin box found in Arabidopsis thaliana U-type cyclins (CycUs) and similar proteins; CycUs interact with cyclin-dependent kinase A-1 (CDKA-1) to trigger its kinase activity. CycUs contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410307  Cd Length: 126  Bit Score: 60.87  E-value: 2.64e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321304  300 FYMKSKPTLSSADFLKRIQDKCEYQPTVYLVATFLIDTLFLTRDGNNILQLKlnlqekeVHRMIIAAVRLSTKLLEDFVH 379
Cdd:cd20604   5 FHGVRAPSISIASYLERIFKYTNCSPSCFVVAYVYIDRFIHKQPGLPISSLN-------VHRLLITSVMVAAKFLDDLYY 77

                        90       100
                ....*....|....*....|....
gi 6321304  380 SHEYFSKVCGISKRLLTKLEVSLL 403
Cdd:cd20604  78 NNAYYAKVGGVSTEELNRLELEFL 101
CYCLIN_ScPCL1-like cd20557
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar ...
 311-403 6.72e-07

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins; The family includes a group of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase, such as Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2, PCL9 and their vertebrate counterparts, cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1). PCL1 (also called PHO85 cyclin-1, or cyclin HCS26) and PCL2 (also called PHO85 cyclin-1, or cyclin HCS26 homolog) are G1/S-specific cyclin partners of the cyclin-dependent kinase (CDK) PHO85. They are essential for the control of the cell cycle at the G1/S (start) transition. The PCL1-PHO85 cyclin-CDK holoenzyme is involved in phosphorylation of the CDK inhibitor (CKI) SIC1, which is required for its ubiquitination and degradation, releasing repression of b-type cyclins and promoting exit from mitosis. Together with cyclin PCL2, it positively controls degradation of sphingoid long chain base kinase LCB4. PCL1-PHO85 also phosphorylates HMS1, NCP1 and NPA3, which may all have a role in mitotic exit. PCL2-PHO85 also phosphorylates RVS167, linking cyclin-CDK activity with organization of the actin cytoskeleton. PCL9 is an M/G1-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. It may have a role in bud site selection in the G1 phase. The family also includes cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1) and similar proteins. Their biological functions remain unclear. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410260  Cd Length: 94  Bit Score: 47.27  E-value: 6.72e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321304  311 ADFLKRIQDKCEYQPTVYLVATFLIDTLFltrdgnNILQLKLNLQEKEVHRMIIAAVRLSTKLLEDFVHSHEYFSKVCGI 390
Cdd:cd20557   3 RSFIARLLRRTRLSPSVVLLALVYLERLR------RRLPEALLGQEGSPYRLFLVALMLASKYLDDESYSNKSWAEISGL 76

                        90
                ....*....|...
gi 6321304  391 SKRLLTKLEVSLL 403
Cdd:cd20557  77 PVRELNAMEREFL 89
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 312-399 2.03e-03

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 37.00  E-value: 2.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321304  312 DFLKRIQDKCEYQPTVYLVATFLIDTLFLTRDgnnilqlklnLQEKEVHRMIIAAVRLSTKlLEDFVHSHEYFSKVCGIS 391
Cdd:cd00043   4 DFIRRLCSKLGLPEEVLELAIELLDRFLSKGL----------LLGRSPELIAAACLYLACK-LEELPRTLKEIAKVSGVS 72


                ....*...
gi 6321304  392 KRLLTKLE 399
Cdd:cd00043  73 EKELRKAE 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH