|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
92-724 |
0e+00 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 579.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 92 ELPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFVLfdEMPHLENTQVACTQPRRVAAMSVAQRVAEEMDVKLGEE 171
Cdd:COG1643 9 DLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALL--ELGWGAGGRIGMLEPRRLAARAAAERMAEELGEPVGET 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 172 VGYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKR-RPDLKIIIMSATL 250
Cdd:COG1643 87 VGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPAlRPDLKLLVMSATL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 251 DAEKFQRYFNDAPLLAVPGRTYPVELYYTP--EFQRDYLDSAIRTVLQIHAtEEAGDILLFLTGEDEIEDAVRkislegd 328
Cdd:COG1643 167 DAERFARLLGDAPVIESSGRTYPVEVRYRPlpADERDLEDAVADAVREALA-EEPGDILVFLPGEREIRRTAE------- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 329 qLVREEGCGPLSVYPLYGSLPPHQQQRIFEPAPEShngrpGRKVVISTNIAETSLTIDGIVYVVDPGFSKQKVYNPRIRV 408
Cdd:COG1643 239 -ALRGRLPPDTEILPLYGRLSAAEQDRAFAPAPHG-----RRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 409 ESLLVSPISKASAQQRAGRAGRTRPGKCFRLYTEEAFQkELIEQSYPEILRSNLSSTVLELKKLGIDDLVHFDFMDPPAP 488
Cdd:COG1643 313 TRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFA-RRPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPA 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 489 ETMMRALEELNYLACLDDEGNLTPLGRLASQFPLDPMLAVMLIGSFEFQCSQEILTIVAMLSVPnvfirptkDKKRADda 568
Cdd:COG1643 392 RAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSER--------DPRRGA-- 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 569 knifahPDGDHITLLNVYHAFKSDeayeygihkwcRDHYLNYRSLSAADNIRSQLERLMNRyNLELNTTDYESpkyfdnI 648
Cdd:COG1643 462 ------AGSDLLARLNLWRRLREQ-----------QREFLSYLRLREWRDLARQLRRLLGE-GANEEPADYEA------I 517
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6321318 649 RKALASGFFMQVAKKRSGAKGYITVKdNQDVLIHPSTVLGHdAEWVIYNEFVLTSKNY-IRTVTSVRPEWLIEIAPA 724
Cdd:COG1643 518 GLLLALAYPDRIARRRGEGGRYLLAR-GRGAALFPGSPLAK-KEWLVAAELVGGAAEArIRLAAPIDPEWLEELAAH 592
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
93-723 |
1.33e-168 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 520.10 E-value: 1.33e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 93 LPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFVLfdEMPHLENTQVACTQPRRVAAMSVAQRVAEEMDVKLGEEV 172
Cdd:TIGR01967 66 LPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICL--ELGRGSHGLIGHTQPRRLAARTVAQRIAEELGTPLGEKV 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 173 GYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRPDLKIIIMSATLDA 252
Cdd:TIGR01967 144 GYKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKIIITSATIDP 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 253 EKFQRYFNDAPLLAVPGRTYPVELYYTP------EFQRDYLDSAIRTVLQIHAtEEAGDILLFLTGEDEIEDAVRkiSLE 326
Cdd:TIGR01967 224 ERFSRHFNNAPIIEVSGRTYPVEVRYRPlveeqeDDDLDQLEAILDAVDELFA-EGPGDILIFLPGEREIRDAAE--ILR 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 327 GDQLVREEgcgplsVYPLYGSLPPHQQQRIFEPapesHNgrpGRKVVISTNIAETSLTIDGIVYVVDPGFSKQKVYNPRI 406
Cdd:TIGR01967 301 KRNLRHTE------ILPLYARLSNKEQQRVFQP----HS---GRRIVLATNVAETSLTVPGIHYVIDTGTARISRYSYRT 367
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 407 RVESLLVSPISKASAQQRAGRAGRTRPGKCFRLYTEEAFQKElIEQSYPEILRSNLSSTVLELKKLGIDDLVHFDFMDPP 486
Cdd:TIGR01967 368 KVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSR-PEFTDPEILRTNLASVILQMLALRLGDIAAFPFIEAP 446
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 487 APETM---MRALEELNYLACLDDEGNLTPLGRLASQFPLDPMLAVMLIGSFEFQCSQEILTIVAMLSVPNVFIRPTKDKK 563
Cdd:TIGR01967 447 DPRAIrdgFRLLEELGALDDDEAEPQLTPIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLIIASALSIQDPRERPMEKQQ 526
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 564 RADDAKNIFAHPDGDHITLLNVYHAFKS--DEAYEYGIHKWCRDHYLNYRSLSAADNIRSQLERLMNRYNLELNttdyES 641
Cdd:TIGR01967 527 AADQAHARFKDPRSDFLSRVNLWRHIEEqrQALSANQFRNACRKQYLNYLRVREWQDIYRQLTQVVKELGLKLN----EE 602
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 642 PKYFDNIRKALASGFFMQVAKKrsGAKGYITVKDNQDVLIHPSTVLGHDA-EWVIYNEFVLTSKNYIRTVTSVRPEWLIE 720
Cdd:TIGR01967 603 PADYDAIHKALLSGLLSQIGMK--DEKHEYDGARGRKFHIFPGSPLFKKPpKWVMAAELVETSKLYARLVAKIEPEWVEP 680
|
...
gi 6321318 721 IAP 723
Cdd:TIGR01967 681 VAG 683
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
93-720 |
2.16e-156 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 488.03 E-value: 2.16e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 93 LPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFVLfdEMPHLENTQVACTQPRRVAAMSVAQRVAEEMDVKLGEEV 172
Cdd:PRK11131 73 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICL--ELGRGVKGLIGHTQPRRLAARTVANRIAEELETELGGCV 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 173 GYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRPDLKIIIMSATLDA 252
Cdd:PRK11131 151 GYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSATIDP 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 253 EKFQRYFNDAPLLAVPGRTYPVELYYTP------EFQRDYLDSAIRTVLQIHAtEEAGDILLFLTGEDEIED---AVRKI 323
Cdd:PRK11131 231 ERFSRHFNNAPIIEVSGRTYPVEVRYRPiveeadDTERDQLQAIFDAVDELGR-EGPGDILIFMSGEREIRDtadALNKL 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 324 SLEGDQLVreegcgplsvyPLYGSLPPHQQQRIFEPapesHNgrpGRKVVISTNIAETSLTIDGIVYVVDPGFSKQKVYN 403
Cdd:PRK11131 310 NLRHTEIL-----------PLYARLSNSEQNRVFQS----HS---GRRIVLATNVAETSLTVPGIKYVIDPGTARISRYS 371
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 404 PRIRVESLLVSPISKASAQQRAGRAGRTRPGKCFRLYTEEAFQKElIEQSYPEILRSNLSSTVLELKKLGIDDLVHFDFM 483
Cdd:PRK11131 372 YRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSR-PEFTDPEILRTNLASVILQMTALGLGDIAAFPFV 450
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 484 DPPAPETM---MRALEELNYLACLDDEGN--LTPLGRLASQFPLDPMLAVMLIGSFEFQCSQEILTIVAMLSVPNVFIRP 558
Cdd:PRK11131 451 EAPDKRNIqdgVRLLEELGAITTDEQASAykLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERP 530
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 559 TKDKKRADDAKNIFAHPDGDHITLLNVYHAFKS--DEAYEYGIHKWCRDHYLNYRSLSAADNIRSQLERLMNRYNLELNT 636
Cdd:PRK11131 531 MDKQQASDEKHRRFADKESDFLAFVNLWNYLQEqqKALSSNQFRRLCRTDYLNYLRVREWQDIYTQLRQVVKELGIPVNS 610
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 637 TdyesPKYFDNIRKALASGFFMQVAKKRSGAKGYITVKdNQDVLIHPSTVL-GHDAEWVIYNEFVLTSKNYIRTVTSVRP 715
Cdd:PRK11131 611 E----PAEYREIHTALLTGLLSHIGMKDAEKQEYTGAR-NARFSIFPGSGLfKKPPKWVMVAELVETSRLWGRIAARIEP 685
|
....*
gi 6321318 716 EWlIE 720
Cdd:PRK11131 686 EW-IE 689
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
81-267 |
1.20e-130 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 385.62 E-value: 1.20e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 81 PKYVDILKIRRELPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFVLFDEMPHLENTQVACTQPRRVAAMSVAQRV 160
Cdd:cd17973 1 QRYFEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQPKKLVACTQPRRVAAMSVAQRV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 161 AEEMDVKLGEEVGYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRPD 240
Cdd:cd17973 81 AEEMDVKLGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPD 160
|
170 180
....*....|....*....|....*..
gi 6321318 241 LKIIIMSATLDAEKFQRYFNDAPLLAV 267
Cdd:cd17973 161 LKLIVMSATLDAGKFQKYFDNAPLLKV 187
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
93-552 |
1.19e-103 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 337.12 E-value: 1.19e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 93 LPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPqFVLFDEmpHLENTQVACTQPRRVAAMSVAQRVAEEMDVKLGEEV 172
Cdd:TIGR01970 1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVP-LALLDA--PGIGGKIIMLEPRRLAARSAAQRLASQLGEAVGQTV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 173 GYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKR-RPDLKIIIMSATLD 251
Cdd:TIGR01970 78 GYRVRGENKVSRRTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVQSSlREDLKILAMSATLD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 252 AEKFQRYFNDAPLLAVPGRTYPVELYYTPEFQRDYLDSAI-RTVLQIHAtEEAGDILLFLTGEDEIEDAVRKISlegDQL 330
Cdd:TIGR01970 158 GERLSSLLPDAPVVESEGRSFPVEIRYLPLRGDQRLEDAVsRAVEHALA-SETGSILVFLPGQAEIRRVQEQLA---ERL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 331 VREegcgpLSVYPLYGSLPPHQQQRIFEPAPEshnGRpgRKVVISTNIAETSLTIDGIVYVVDPGFSKQKVYNPRIRVES 410
Cdd:TIGR01970 234 DSD-----VLICPLYGELSLAAQDRAIKPDPQ---GR--RKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKTGITR 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 411 LLVSPISKASAQQRAGRAGRTRPGKCFRLYTEEAFQKeLIEQSYPEILRSNLSSTVLELKKLGIDDLVHFDFMDPPAPET 490
Cdd:TIGR01970 304 LETVRISQASATQRAGRAGRLEPGVCYRLWSEEQHQR-LPAQDEPEILQADLSGLALELAQWGAKDPSDLRWLDAPPSVA 382
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6321318 491 MMRALEELNYLACLDDEGNLTPLGRLASQFPLDPMLAVMLIGSFEFQCSQEILTIVAMLSVP 552
Cdd:TIGR01970 383 LAAARQLLQRLGALDAQGRLTAHGKAMAALGCHPRLAAMLLSAHSTGLAALACDLAALLEER 444
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
93-549 |
5.63e-97 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 318.79 E-value: 5.63e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 93 LPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIP-QFVLFDEMP----HLEntqvactqPRRVAAMSVAQRVAEEMDVK 167
Cdd:PRK11664 4 LPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPlQLLQHGGINgkiiMLE--------PRRLAARNVAQRLAEQLGEK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 168 LGEEVGYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKR-RPDLKIIIM 246
Cdd:PRK11664 76 PGETVGYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQGlRDDLKLLIM 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 247 SATLDAEKFQRYFNDAPLLAVPGRTYPVELYYTPEFQRDYLDSAI-RTVLQIhATEEAGDILLFLTGEDEIedavrkisl 325
Cdd:PRK11664 156 SATLDNDRLQQLLPDAPVIVSEGRSFPVERRYQPLPAHQRFDEAVaRATAEL-LRQESGSLLLFLPGVGEI--------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 326 egdQLVREEGCGPLS----VYPLYGSLPPHQQQRIFEPAPeshNGRpgRKVVISTNIAETSLTIDGIVYVVDPGFSKQKV 401
Cdd:PRK11664 226 ---QRVQEQLASRVAsdvlLCPLYGALSLAEQQKAILPAP---AGR--RKVVLATNIAETSLTIEGIRLVVDSGLERVAR 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 402 YNPRIRVESLLVSPISKASAQQRAGRAGRTRPGKCFRLYTEEAFQKeLIEQSYPEILRSNLSSTVLELKKLGIDDLVHFD 481
Cdd:PRK11664 298 FDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAER-AAAQSEPEILHSDLSGLLLELLQWGCHDPAQLS 376
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6321318 482 FMDPPAPETMMRALEELNYLACLDDEGNLTPLGRLASQFPLDPMLAVMLIGSFEFqcSQEILTIVAML 549
Cdd:PRK11664 377 WLDQPPAAALAAAKRLLQQLGALDGQGRLTARGRKMAALGNDPRLAAMLVAAKED--DEAALATAAKL 442
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
109-267 |
9.51e-94 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 288.97 E-value: 9.51e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 109 NQIMVFVGETGSGKTTQIPQFVLFDEMPHLENTQVACTQPRRVAAMSVAQRVAEEMDVKLGEEVGYSIRFENKTSNKTIL 188
Cdd:cd17917 1 NQVVVIVGETGSGKTTQVPQFLLEDGLAKGGKGRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTRI 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6321318 189 KYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRPDLKIIIMSATLDAEKFQRYFNDAPLLAV 267
Cdd:cd17917 81 KFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAPVIHI 159
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
90-268 |
5.99e-83 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 261.65 E-value: 5.99e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 90 RRELPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFVlfDEMPHLENTQVACTQPRRVAAMSVAQRVAEEMDVKLG 169
Cdd:cd17971 3 RESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYL--AEAGYTSRGKIGCTQPRRVAAMSVAKRVAEEFGCCLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 170 EEVGYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRPDLKIIIMSAT 249
Cdd:cd17971 81 QEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIVTSAT 160
|
170
....*....|....*....
gi 6321318 250 LDAEKFQRYFNDAPLLAVP 268
Cdd:cd17971 161 LDAVKFSQYFYEAPIFTIP 179
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
272-440 |
5.55e-82 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 258.62 E-value: 5.55e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 272 YPVELYYTPE-----------FQRDYLDSAIRTVLQIHATEEAGDILLFLTGEDEIEDAVRKISlegdQLVREEGCGPLS 340
Cdd:cd18791 1 FPVEVYYLEDilellgissekEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLR----EELLSPDLGKLL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 341 VYPLYGSLPPHQQQRIFEPAPESHngrpgRKVVISTNIAETSLTIDGIVYVVDPGFSKQKVYNPRIRVESLLVSPISKAS 420
Cdd:cd18791 77 VLPLHSSLPPEEQQRVFEPPPPGV-----RKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKAS 151
|
170 180
....*....|....*....|
gi 6321318 421 AQQRAGRAGRTRPGKCFRLY 440
Cdd:cd18791 152 AEQRAGRAGRTRPGKCYRLY 171
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
93-265 |
6.99e-82 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 258.82 E-value: 6.99e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 93 LPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFvLFDEMPHlENTQVACTQPRRVAAMSVAQRVAEEMDVKLGEEV 172
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQY-LYEAGFA-RGGMIGITQPRRVAAVSVAKRVAEEMGVELGQLV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 173 GYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRR-----PDLKIIIMS 247
Cdd:cd17978 79 GYSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklSPLKVIIMS 158
|
170
....*....|....*...
gi 6321318 248 ATLDAEKFQRYFNDAPLL 265
Cdd:cd17978 159 ATLDADLFSEYFNGAPVL 176
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
93-267 |
1.24e-81 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 257.82 E-value: 1.24e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 93 LPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFvLFDEMPHLENTQVACTQPRRVAAMSVAQRVAEEMDVKLGEEV 172
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQY-LHEAGYTKGGGKIGCTQPRRVAAMSVAARVAEEMGVKLGNEV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 173 GYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRPDLKIIIMSATLDA 252
Cdd:cd17974 80 GYSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSATMDA 159
|
170
....*....|....*
gi 6321318 253 EKFQRYFNDAPLLAV 267
Cdd:cd17974 160 EKFSAFFDDAPIFRI 174
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
93-267 |
4.13e-78 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 248.53 E-value: 4.13e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 93 LPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFVLFDEmpHLENTQVACTQPRRVAAMSVAQRVAEEMDVKLGEEV 172
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDG--YTDYGMIGCTQPRRVAAMSVAKRVSEEMGVELGEEV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 173 GYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRPDLKIIIMSATLDA 252
Cdd:cd17983 79 GYAIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSATMDA 158
|
170
....*....|....*
gi 6321318 253 EKFQRYFNDAPLLAV 267
Cdd:cd17983 159 DKFADFFGNVPIFTI 173
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
93-260 |
4.39e-72 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 233.13 E-value: 4.39e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 93 LPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFvLFDEMPHLENTQVACTQPRRVAAMSVAQRVAEEMDVKLGEEV 172
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQY-LAEAGWTAGGRVVGCTQPRRVAAVTVAGRVAEEMGAVLGHEV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 173 GYSIRFENKTSN-KTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRPDLKIIIMSATLD 251
Cdd:cd17980 80 GYCIRFDDCTDPqATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASATLD 159
|
....*....
gi 6321318 252 AEKFQRYFN 260
Cdd:cd17980 160 AEKFRDFFN 168
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
93-267 |
6.88e-67 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 218.86 E-value: 6.88e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 93 LPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFVLfdEMPHLENTQVACTQPRRVAAMSVAQRVAEEMDVKLGEEV 172
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICL--ELGRGIRGLIGHTQPRRLAARSVAERIAEELKTELGGAV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 173 GYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRPDLKIIIMSATLDA 252
Cdd:cd17989 79 GYKVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSATIDA 158
|
170
....*....|....*
gi 6321318 253 EKFQRYFNDAPLLAV 267
Cdd:cd17989 159 ERFSRHFNNAPIIEV 173
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
93-267 |
9.56e-60 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 199.70 E-value: 9.56e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 93 LPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFVLfdEMPHLENTQVACTQPRRVAAMSVAQRVAEEMDVKLGEEV 172
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLY--EAGFSQHGMIGVTQPRRVAAISVAQRVAEEMKCTLGSKV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 173 GYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVV-----KRRPDLKIIIMS 247
Cdd:cd17984 79 GYQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFqekspNRKEHLKVVVMS 158
|
170 180
....*....|....*....|
gi 6321318 248 ATLDAEKFQRYFNDAPLLAV 267
Cdd:cd17984 159 ATLELAKLSAFFGNCPVFDI 178
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
93-263 |
1.53e-57 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 194.11 E-value: 1.53e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 93 LPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFVL---FDEMPHLENTQVACTQPRRVAAMSVAQRVAEEMDVkLG 169
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYeagFGSPESDNPGMIGITQPRRVAAVSMAKRVAEELNV-FG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 170 EEVGYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRPD--------- 240
Cdd:cd17982 80 KEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdqtvk 159
|
170 180
....*....|....*....|....*..
gi 6321318 241 -LKIIIMSATLDAEKF---QRYFNDAP 263
Cdd:cd17982 160 pLKLVIMSATLRVEDFtenKLLFPRPP 186
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
93-267 |
1.14e-53 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 183.03 E-value: 1.14e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 93 LPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFVLFDEMPHlentqVACTQPRRVAAMSVAQRVAEEMDVKLGEEV 172
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRH-----IACTQPRRIACISLAKRVAFESLNQYGSKV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 173 GYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRPDLKIIIMSATLDA 252
Cdd:cd17979 76 AYQIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSATINI 155
|
170
....*....|....*
gi 6321318 253 EKFQRYFNDAPLLAV 267
Cdd:cd17979 156 ELFSGYFEGAPVVQV 170
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
93-267 |
1.37e-52 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 180.42 E-value: 1.37e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 93 LPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFVLFDEM--PHLENTQVACTQPRRVAAMSVAQRVAEEMDVKLGE 170
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLqgPPLPVANIICTQPRRISAISVAERVAQERAERVGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 171 EVGYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRPDLKIIIMSATL 250
Cdd:cd17985 81 SVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSATL 160
|
170
....*....|....*..
gi 6321318 251 DAEKFQRYFNDAPLLAV 267
Cdd:cd17985 161 NAELFSDYFNSCPVIHI 177
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
93-267 |
1.86e-52 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 180.04 E-value: 1.86e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 93 LPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFVLFDEMPHLENT--QVACTQPRRVAAMSVAQRVAEEM--DVKL 168
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERGKGSscRIVCTQPRRISAISVAERVAAERaeSCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 169 GEEVGYSIRFENKTSNK--TILkYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRPDLKIIIM 246
Cdd:cd17981 81 GNSTGYQIRLESRKPRKqgSIL-YCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILM 159
|
170 180
....*....|....*....|.
gi 6321318 247 SATLDAEKFQRYFNDAPLLAV 267
Cdd:cd17981 160 SATLNAEKFSDYFNNCPMIHI 180
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
93-267 |
3.11e-52 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 179.25 E-value: 3.11e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 93 LPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQ----FVLFDempHLENTQVACTQPRRVAAMSVAQRVAEEMDVKL 168
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQwcaeYCLSA---HYQHGVVVCTQVHKQTAVWLALRVADEMDVNI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 169 GEEVGYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRPDLKIIIMSA 248
Cdd:cd17977 78 GHEVGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITC 157
|
170
....*....|....*....
gi 6321318 249 TLDAEKFQRYFNDAPLLAV 267
Cdd:cd17977 158 PHLSSKLLSYYGNVPLIEV 176
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
93-267 |
2.53e-51 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 177.03 E-value: 2.53e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 93 LPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFVLFDEMPHLENTQ---VACTQPRRVAAMSVAQRVAEEMDVKLG 169
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLLNGGTAQkcnIVCTQPRRISAMSLATRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 170 -----EEVGYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRPDLKII 244
Cdd:cd17975 81 pggknSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHLI 160
|
170 180
....*....|....*....|...
gi 6321318 245 IMSATLDAEKFQRYFNDAPLLAV 267
Cdd:cd17975 161 LMSATVDCEKFSSYFTHCPILRI 183
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
93-267 |
3.33e-50 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 173.86 E-value: 3.33e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 93 LPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFVLFDEMPHLENTQVACTQPRRVAAMSVAQRVAEEMDVKLGEEV 172
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYANGIPCRIFCTQPRRLAAIAVAERVAAERGEKIGQTV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 173 GYSIRFENKTSNKTILKYMTDGMLLREAME-DHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRPDLKIIIMSATLD 251
Cdd:cd17987 81 GYQIRLESRVSPKTLLTFCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSAALD 160
|
170
....*....|....*.
gi 6321318 252 AEKFQRYFNDAPLLAV 267
Cdd:cd17987 161 VNLFIRYFGSCPVIYI 176
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
93-267 |
6.49e-47 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 164.43 E-value: 6.49e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 93 LPVHAQRDEFLK-LYQNNQImVFVGETGSGKTTQIPQFVLfdEMPHLENTQVACTQPRRVAAMSVAQRVAEEMDVKLGEE 171
Cdd:cd17990 1 LPIAAVLPALRAaLDAGGQV-VLEAPPGAGKTTRVPLALL--AELWIAGGKIIVLEPRRVAARAAARRLATLLGEAPGET 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 172 VGYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVK-RRPDLKIIIMSATL 250
Cdd:cd17990 78 VGYRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQlLRDDLRLLAMSATL 157
|
170
....*....|....*..
gi 6321318 251 DAEKFQRYFNDAPLLAV 267
Cdd:cd17990 158 DGDGLAALLPEAPVVES 174
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
93-267 |
9.65e-46 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 161.50 E-value: 9.65e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 93 LPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFVLFDEMphLENTQVAC----TQPRRVAAMSVAQRVAEEMDVKL 168
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYV--LRGRGARCnvviTQPRRISAVSVAQRVAHELGPNL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 169 GEEVGYSIRFENKTSNKT-ILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRPDLKIIIMS 247
Cdd:cd17976 79 RRNVGYQVRLESRPPPRGgALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMS 158
|
170 180
....*....|....*....|
gi 6321318 248 ATLDAEKFQRYFNDAPLLAV 267
Cdd:cd17976 159 ATGDNQRLSRYFGGCPVVRV 178
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
77-267 |
1.07e-42 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 154.99 E-value: 1.07e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 77 REFTPKYVDILKIRRELPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFVLFDempHLENTQVA-----CTQPRRV 151
Cdd:cd17972 43 REQDHNLQQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDD---FIQNDRAAecnivVTQPRRI 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 152 AAMSVAQRVAEEMDVKLGEEVGYSIRFENKTSNK--TILkYMTDGMLLReaMEDHDLSRYSCIILDEAHERTLATDILMG 229
Cdd:cd17972 120 SAVSVAERVAFERGEEVGKSCGYSVRFESVLPRPhaSIL-FCTVGVLLR--KLEAGIRGISHVIVDEIHERDINTDFLLV 196
|
170 180 190
....*....|....*....|....*....|....*...
gi 6321318 230 LLKQVVKRRPDLKIIIMSATLDAEKFQRYFNDAPLLAV 267
Cdd:cd17972 197 VLRDVVQAYPDLRVILMSATIDTSMFCEYFFNCPVIEV 234
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
93-267 |
2.38e-41 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 148.89 E-value: 2.38e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 93 LPVHAQRDEFLKLYQNNQIMVFV-GETGSGKTTQIPQ----FVLFDEMPHlenTQVACTQPRRVAAMSVAQRVAEEMDVK 167
Cdd:cd17986 1 LPIWAAKFTFLEQLESPSGIVLVsGEPGSGKSTQVPQwcaeFALSRGFQK---GQVTVTQPHPLAARSLALRVADEMDLN 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 168 LGEEVGYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRPDLKIIIMS 247
Cdd:cd17986 78 LGHEVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVT 157
|
170 180
....*....|....*....|
gi 6321318 248 ATLDAEKFQRYFNDAPLLAV 267
Cdd:cd17986 158 SPALEPKLRAFWGNPPVVHV 177
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
93-267 |
9.11e-39 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 141.87 E-value: 9.11e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 93 LPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFVLFDEMPHLENTQVACTQPRRVAAMSVAQRVAEEMDVKLGEEV 172
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYKRGKYCNIVVTQPRRIAAISIARRVSQEREWTLGSLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 173 GYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRPD-LKIIIMSATLD 251
Cdd:cd17988 81 GYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRhVKIILMSATIS 160
|
170 180
....*....|....*....|
gi 6321318 252 AEKFQRYF----NDAPLLAV 267
Cdd:cd17988 161 CKEFADYFttpnNPAYVFEV 180
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
648-725 |
5.52e-30 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 113.12 E-value: 5.52e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 648 IRKALASGFFMQVAKKRSGAKGYITVKDNQDVLIHPSTVL----GHDAEWVIYNEFVLTSKNYIRTVTSVRPEWLIEIAP 723
Cdd:pfam07717 1 LRAALAAGLYPNVARRDPKGKGYTTLSDNQRVFIHPSSVLfnekTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLFAP 80
|
..
gi 6321318 724 AY 725
Cdd:pfam07717 81 HI 82
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
494-582 |
5.36e-29 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 111.18 E-value: 5.36e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 494 ALEELNYLACLDDEGNLTPLGRLASQFPLDPMLAVMLIGSFEFQCSQEILTIVAMLSVPNVFIRP-------------TK 560
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPnfldprsaakaarRR 80
|
90 100
....*....|....*....|....
gi 6321318 561 DKKRADDAKNIFAHPD--GDHITL 582
Cdd:pfam04408 81 RRAADEKARAKFARLDleGDHLTL 104
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
500-583 |
1.12e-28 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 109.67 E-value: 1.12e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 500 YLACLDDEGNLTPLGRLASQFPLDPMLAVMLIGSFEFQCSQEILTIVAMLSVPNvfIRPTKDKKRADDAKNIFAHPDGDH 579
Cdd:smart00847 1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGD--PRPKEKREDADAARRRFADPESDH 78
|
....
gi 6321318 580 ITLL 583
Cdd:smart00847 79 LTLL 82
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
98-273 |
2.14e-26 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 107.19 E-value: 2.14e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 98 QRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFvLFDEMPHLENTQVACTQPRRVAAMSVAQRVAEEMD----VKLGEEVG 173
Cdd:smart00487 13 QKEAIEALLSGLRDVILAAPTGSGKTLAALLP-ALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPslglKVVGLYGG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 174 YSIR--FENKTSNKTILKYMTDGMLLREAMEDH-DLSRYSCIILDEAHERT--LATDILMGLLKQVvkrRPDLKIIIMSA 248
Cdd:smart00487 92 DSKReqLRKLESGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLLdgGFGDQLEKLLKLL---PKNVQLLLLSA 168
|
170 180
....*....|....*....|....*..
gi 6321318 249 TL--DAEKFQRYFNDAPLLAVPGRTYP 273
Cdd:smart00487 169 TPpeEIENLLELFLNDPVFIDVGFTPL 195
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
69-441 |
1.58e-13 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 74.24 E-value: 1.58e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 69 GKINPFTGREFtpkyvdilkirRELPVHAQRdEFLKLYQNNQIMVFVGETGSGKTTQIPQFVL--------FDEM----P 136
Cdd:PHA02653 151 GNPEPFSKIPL-----------ASLQPDVQL-KIFEAWISRKPVVLTGGTGVGKTSQVPKLLLwfnylfggFDNLdkidP 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 137 HLENTQVACTQPRR--VAAMSVAQRVAEEMDVKLGEEVgySIRFENKTS---NKTILKYmtdGMLLreamEDHDLS---- 207
Cdd:PHA02653 219 NFIERPIVLSLPRValVRLHSITLLKSLGFDEIDGSPI--SLKYGSIPDeliNTNPKPY---GLVF----STHKLTlnkl 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 208 -RYSCIILDEAHERTLATDILMGLL-KQVVKRRpdlKIIIMSATL--DAEKFQRYFNDAPLLAVPGRT-YPV-ELY---- 277
Cdd:PHA02653 290 fDYGTVIIDEVHEHDQIGDIIIAVArKHIDKIR---SLFLMTATLedDRDRIKEFFPNPAFVHIPGGTlFPIsEVYvknk 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 278 YTPEFQRDYLDSAIRTVLQI---HATEEAGDILLFLTGEDEIEDAVRKIslegdqlvrEEGCGPLSVYPLYGSLPphqqq 354
Cdd:PHA02653 367 YNPKNKRAYIEEEKKNIVTAlkkYTPPKGSSGIVFVASVSQCEEYKKYL---------EKRLPIYDFYIIHGKVP----- 432
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 355 RIFEPAPESHNgRPGRKVVISTNIAETSLTIDGIVYVVDPGfskqKVYNPrirvesllvSP-------ISKASAQQRAGR 427
Cdd:PHA02653 433 NIDEILEKVYS-SKNPSIIISTPYLESSVTIRNATHVYDTG----RVYVP---------EPfggkemfISKSMRTQRKGR 498
|
410
....*....|....
gi 6321318 428 AGRTRPGKCFRLYT 441
Cdd:PHA02653 499 VGRVSPGTYVYFYD 512
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
339-430 |
1.27e-12 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 63.77 E-value: 1.27e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 339 LSVYPLYGSLPPHQQQRIFEPAPESHNgrpgrKVVISTNIAETSLTIDGIVYVVDPGFskqkvynprirvesllvsPISK 418
Cdd:smart00490 12 IKVARLHGGLSQEEREEILDKFNNGKI-----KVLVATDVAERGLDLPGVDLVIIYDL------------------PWSP 68
|
90
....*....|..
gi 6321318 419 ASAQQRAGRAGR 430
Cdd:smart00490 69 ASYIQRIGRAGR 80
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
291-430 |
7.03e-11 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 59.92 E-value: 7.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 291 IRTVLQIHATEEAGDILLFLTgedeiedavRKISLEGDQLVREEGcgpLSVYPLYGSLPPHQQQRIFEPAPESHngrpgR 370
Cdd:pfam00271 3 LEALLELLKKERGGKVLIFSQ---------TKKTLEAELLLEKEG---IKVARLHGDLSQEEREEILEDFRKGK-----I 65
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 371 KVVISTNIAETSLTIDGIVYVVDpgfskqkvYNPrirvesllvsPISKASAQQRAGRAGR 430
Cdd:pfam00271 66 DVLVATDVAERGLDLPDVDLVIN--------YDL----------PWNPASYIQRIGRAGR 107
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
98-253 |
1.38e-10 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 60.72 E-value: 1.38e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 98 QRDEFLKLYQNNQIMVfVGETGSGKTT--QIPQFVLFDEmpHLENTQVACTQPRRVAA---MSVAQRVAEEMDVKLGEEV 172
Cdd:pfam00270 4 QAEAIPAILEGRDVLV-QAPTGSGKTLafLLPALEALDK--LDNGPQALVLAPTRELAeqiYEELKKLGKGLGLKVASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 173 -GYSIRFENKTSNKTILKYMTDGMLLREAMEDHDLSRYSCIILDEAHErtLATDILMGLLKQVVKR-RPDLKIIIMSATL 250
Cdd:pfam00270 81 gGDSRKEQLEKLKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAHR--LLDMGFGPDLEEILRRlPKKRQILLLSATL 158
|
...
gi 6321318 251 DAE 253
Cdd:pfam00270 159 PRN 161
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
115-249 |
2.61e-09 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 56.26 E-value: 2.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 115 VGETGSGKTTQIPQFVL--FDEMPhlenTQVACTQPRRVAAMSVAQRVAEE--MDVKLGEEVGYS---IRFENKTSNKTI 187
Cdd:cd00046 7 TAPTGSGKTLAALLAALllLLKKG----KKVLVLVPTKALALQTAERLRELfgPGIRVAVLVGGSsaeEREKNKLGDADI 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6321318 188 LkYMTDGMLLR--EAMEDHDLSRYSCIILDEAHERTLATD-ILMGLLKQVVKRRPDLKIIIMSAT 249
Cdd:cd00046 83 I-IATPDMLLNllLREDRLFLKDLKLIIVDEAHALLIDSRgALILDLAVRKAGLKNAQVILLSAT 146
|
|
| DEXHc_viral_Ns3 |
cd17931 |
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ... |
110-249 |
7.17e-07 |
|
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350689 [Multi-domain] Cd Length: 151 Bit Score: 49.47 E-value: 7.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 110 QIMVFVGETGSGKTTQIPQFVLFDEMPhlENTQVACTQPRRVAAMSVAQRVAeemdvklGEEVGYSIRFENKT-SNKTIL 188
Cdd:cd17931 2 QLTVLDLHPGAGKTTRVLPQIIREAIK--KRLRTLVLAPTRVVAAEMYEALR-------GLPIRYRTGAVKEEhGGNEIV 72
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6321318 189 KYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKrRPDLKIIIMSAT 249
Cdd:cd17931 73 DYMCHGTFTCRLLSPKRVPNYNLIIMDEAHFTDPASIAARGYIHTRVE-MGEAAVIFMTAT 132
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
371-440 |
6.96e-05 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 41.54 E-value: 6.96e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6321318 371 KVVISTNIAETSLTIDGIVYVVDPGFskqkvynprirvesllvsPISKASAQQRAGRAGR--TRPGKCFRLY 440
Cdd:cd18785 24 EILVATNVLGEGIDVPSLDTVIFFDP------------------PSSAASYIQRVGRAGRggKDEGEVILFV 77
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
96-265 |
3.22e-04 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 42.25 E-value: 3.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 96 HAQRDEFLKLYQNNQIMVFVGETGSGKTTqIPQFVLFdemphlentQVACTQPRRVAAMS-----VAQRVAE--EMDVKL 168
Cdd:cd17921 4 PIQREALRALYLSGDSVLVSAPTSSGKTL-IAELAIL---------RALATSGGKAVYIAptralVNQKEADlrERFGPL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 169 GEEVGYSIRFEnKTSNKTILKY----MT----DGMLLREamEDHDLSRYSCIILDEAH-----ERtlaTDILMGLLKQVV 235
Cdd:cd17921 74 GKNVGLLTGDP-SVNKLLLAEAdilvATpeklDLLLRNG--GERLIQDVRLVVVDEAHligdgER---GVVLELLLSRLL 147
|
170 180 190
....*....|....*....|....*....|.
gi 6321318 236 KRRPDLKIIIMSATLD-AEKFQRYFNDAPLL 265
Cdd:cd17921 148 RINKNARFVGLSATLPnAEDLAEWLGVEDLI 178
|
|
| AAA_22 |
pfam13401 |
AAA domain; |
110-246 |
5.01e-04 |
|
AAA domain;
Pssm-ID: 379165 [Multi-domain] Cd Length: 129 Bit Score: 40.79 E-value: 5.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 110 QIMVFVGETGSGKTTQIPQfvLFDEMPHLENTQVACTQPRRVAAMSVAQRVAEEMDVKLGEEvgysirfenktsnktilk 189
Cdd:pfam13401 6 GILVLTGESGTGKTTLLRR--LLEQLPEVRDSVVFVDLPSGTSPKDLLRALLRALGLPLSGR------------------ 65
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 6321318 190 ymTDGMLLREAMEDH--DLSRYSCIILDEAHErtLATDILMGLLKQVVKRRPDLKIIIM 246
Cdd:pfam13401 66 --LSKEELLAALQQLllALAVAVVLIIDEAQH--LSLEALEELRDLLNLSSKLLQLILV 120
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
206-549 |
6.25e-04 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 42.96 E-value: 6.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 206 LSRYSCIILDEAH-----ERTLatdILMGLLKQVVKRRPDLKIIIMSATLD-AEKFQRYFnDAPLLAVPGRtyPVEL--- 276
Cdd:COG1204 135 LRDVDLVVVDEAHliddeSRGP---TLEVLLARLRRLNPEAQIVALSATIGnAEEIAEWL-DAELVKSDWR--PVPLneg 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 277 -YYTPE--FQRDYLDSAIRTV-LQIHATEEAGDILLFLTGEDEIEDAVRKIS---------------LEGDQLVREEGCG 337
Cdd:COG1204 209 vLYDGVlrFDDGSRRSKDPTLaLALDLLEEGGQVLVFVSSRRDAESLAKKLAdelkrrltpeereelEELAEELLEVSEE 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 338 PLSVYPL-----------YGSLPPHQQQRI---FepapeshngRPGR-KVVISTN-IAEtsltidGI------VYVVDPG 395
Cdd:COG1204 289 THTNEKLadclekgvafhHAGLPSELRRLVedaF---------REGLiKVLVATPtLAA------GVnlparrVIIRDTK 353
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 396 FSKQKvynprirvesllvsPISKASAQQRAGRAGrtRPGK-------CFRLYTEEAfqKELIEQSY---PEILRSNLSST 465
Cdd:COG1204 354 RGGMV--------------PIPVLEFKQMAGRAG--RPGYdpygeaiLVAKSSDEA--DELFERYIlgePEPIRSKLANE 415
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 466 ------VLELKKLGI----DDLVHF---DFMDPPAPETMMRA--------LEELNYLACLDDEGNLTPLGRLASQFPLDP 524
Cdd:COG1204 416 salrthLLALIASGFansrEELLDFlenTFYAYQYDKGDLEEvvddalefLLENGFIEEDGDRLRATKLGKLVSRLYIDP 495
|
410 420
....*....|....*....|....*....
gi 6321318 525 MLAVMLIGSF----EFQCSQEILTIVAML 549
Cdd:COG1204 496 LTAAELVDGLrkadEEFTDLGLLHLILIL 524
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
209-430 |
1.79e-03 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 41.26 E-value: 1.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 209 YSCIILDEAHerTLATDILMGLLKQV-VKRRPDLKIIIMSATLdAEKFQRYF--NDAPLLAVPGRTYPVELYYTPEFQRD 285
Cdd:cd09639 124 NSLLIFDEVH--FYDEYTLALILAVLeVLKDNDVPILLMSATL-PKFLKEYAekIGYVEENEPLDLKPNERAPFIKIESD 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 286 YLDSAIRTVLQIHATEEAGDILLFLtgeDEIEDAVrkislEGDQLVREEgcGPLSVYPLYGS--LPPHQQQRIFEPAPES 363
Cdd:cd09639 201 KVGEISSLERLLEFIKKGGSVAIIV---NTVDRAQ-----EFYQQLKEK--GPEEEIMLIHSrfTEKDRAKKEAELLLEF 270
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6321318 364 HNGRPGrkVVISTNIAETSLTIDGIVYVVDPgfskqkvynprirvesllvSPISkaSAQQRAGRAGR 430
Cdd:cd09639 271 KKSEKF--VIVATQVIEASLDISVDVMITEL-------------------APID--SLIQRLGRLHR 314
|
|
| FlhF |
TIGR03499 |
flagellar biosynthetic protein FlhF; [Cellular processes, Chemotaxis and motility] |
12-124 |
3.79e-03 |
|
flagellar biosynthetic protein FlhF; [Cellular processes, Chemotaxis and motility]
Pssm-ID: 274609 [Multi-domain] Cd Length: 282 Bit Score: 40.01 E-value: 3.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 12 PDPVETSIPEQAAEIAEELSKQ-HPLP-SEEPLVHHDAGEFkgLQRHHTSAEEAQKLEDgKINPFTGREFTPKYVdILKI 89
Cdd:TIGR03499 102 PLLPEEELRKELEALRELLERLlAGLAwLQRPPERAKLYER--LLEAGVSEELARELLE-KLPEDADAEDAWRWL-REAL 177
|
90 100 110
....*....|....*....|....*....|....*
gi 6321318 90 RRELPVHAQRDEFLKlyqNNQIMVFVGETGSGKTT 124
Cdd:TIGR03499 178 EGMLPVKPEEDPILE---QGGVIALVGPTGVGKTT 209
|
|
| SRP_G_like |
cd03115 |
GTPase domain similar to the signal recognition particle subunit 54; The signal recognition ... |
111-266 |
4.71e-03 |
|
GTPase domain similar to the signal recognition particle subunit 54; The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal signal sequences of newly synthesized polypeptides at the ribosome. The SRP-polypeptide complex is then targeted to the membrane by an interaction between SRP and its cognate receptor (SR). In mammals, SRP consists of six protein subunits and a 7SL RNA. One of these subunits is a 54 kd protein (SRP54), which is a GTP-binding protein that interacts with the signal sequence when it emerges from the ribosome. SRP54 is a multidomain protein that consists of an N-terminal domain, followed by a central G (GTPase) domain and a C-terminal M domain.
Pssm-ID: 349769 [Multi-domain] Cd Length: 193 Bit Score: 38.89 E-value: 4.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321318 111 IMVFVGETGSGKTTQIPQFVLFDEMPHLEnTQVACTQPRRVAAMSVAQRVAEEMDVKLgeevgysirFENKTSNKTIlky 190
Cdd:cd03115 2 VILLVGLQGSGKTTTLAKLARYYQEKGKK-VLLIAADTFRAAAVEQLKTLAEKLGVPV---------FESYTGTDPA--- 68
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6321318 191 mtdgMLLREAMEDHDLSRYSCIILDEAHeRTLATDILMGLLKQVVK-RRPDLKIIIMSATL--DAEKFQRYFNDAPLLA 266
Cdd:cd03115 69 ----SIAQEAVEKAKLEGYDVLLVDTAG-RLQKDEPLMEELKKVKEvESPDEVLLVLDATTgqEALSQAKAFNEAVGLT 142
|
|
| |
