NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|6321493|ref|NP_011570|]
View 

RSC subunit protein RSC1 [Saccharomyces cerevisiae S288C]

Protein Classification

bromodomain-containing protein; histone acetyltransferase GCN5 family protein( domain architecture ID 11564917)

bromodomain-containing protein may act as transcription regulator involved in chromatin-based DNA damage response (DDR) pathways, which maintain genome integrity from cell-intrinsic and extrinsic DNA-damaging sources| histone acetyltransferase GCN5 family protein contains a bromodomain, similar to Arabidopsis thaliana GCN5 that acetylates 'Lys-14' of histone H3

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 115-463 2.09e-88

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


:

Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 286.70  E-value: 2.09e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  115 KHYPEVTYPSLGRIP----EIFAESMQPSDLSSNPI-NTQENDEKAGLNP-EMKMAFAKLDSSIT-ERKPT-----NQDY 182
Cdd:COG5076   1 LEFDEVSYSQLGRPSvlkeEFGNELLRLVDNDSSPFpNAPEEEGSKNLFQkQLKRMPKEYITSIVdDREPGsmanvNDDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  183 RMQQKN--SPAF-----PTHSASITPQPLASPTPVVNYANITSAHPKT-HVRRGRPPVIDLPYVLRIKNILKMMRREVDQ 254
Cdd:COG5076  81 ENVGGItySPFEknrpeSLRFDEIVFLAIESVTPESGLGSLLMAHLKTsVKKRKTPKIEDELLYADNKAIAKFKKQLFLR 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  255 NNKTLTLCFEKLPDRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLYYSQDQSNIIRAQLLEKN 334
Cdd:COG5076 161 DGRFLSSIFLGLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVYVDAKELEKY 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  335 FNRLVR-IELSKPDEDYLPEGELRYPLDDVEINDEKYQIGDWVLLHNPNDINKPIVGQIFRLWSTTDGNKWLNACWYFRP 413
Cdd:COG5076 241 FLKLIEeIPEEMLELSIKPGREEREERESVLITNSQAHVGAWPFLRPVSDEEVPDYYKDIRDPMDLSTKELKLRNNYYRP 320

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|
gi 6321493  414 EQTVHRVDRLFYKNEVMKTGQYRDHPIQDIKGKCYVIHFTRFQRGDPSTK 463
Cdd:COG5076 321 EETFVRDAKLFFDNCVMYNGEVTDYYKNANVLEDFVIKKTRLIREYPKLI 370
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 8-113 1.48e-55

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


:

Pssm-ID: 99952  Cd Length: 106  Bit Score: 187.14  E-value: 1.48e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493    8 FLQKLLKTQYDAVFHLKDENGIEIYPIFNVLPPKKEYPDYYIIIRNPISLNTLKKRLPHYTSPQDFVNDFAQIPWNAMTY 87
Cdd:cd05521   1 KLSKKLKPLYDGIYTLKEENGIEIHPIFNVLPLRKDYPDYYKIIKNPLSLNTVKKRLPHYTNAQEFVNDLAQIPWNARLY 80

                        90       100
                ....*....|....*....|....*.
gi 6321493   88 NAKDSVIYKYAILLESFIKGKIVHNI 113
Cdd:cd05521  81 NTKGSVIYKYALILEKYINDVIIPNL 106
 
Name Accession Description Interval E-value
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 115-463 2.09e-88

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 286.70  E-value: 2.09e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  115 KHYPEVTYPSLGRIP----EIFAESMQPSDLSSNPI-NTQENDEKAGLNP-EMKMAFAKLDSSIT-ERKPT-----NQDY 182
Cdd:COG5076   1 LEFDEVSYSQLGRPSvlkeEFGNELLRLVDNDSSPFpNAPEEEGSKNLFQkQLKRMPKEYITSIVdDREPGsmanvNDDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  183 RMQQKN--SPAF-----PTHSASITPQPLASPTPVVNYANITSAHPKT-HVRRGRPPVIDLPYVLRIKNILKMMRREVDQ 254
Cdd:COG5076  81 ENVGGItySPFEknrpeSLRFDEIVFLAIESVTPESGLGSLLMAHLKTsVKKRKTPKIEDELLYADNKAIAKFKKQLFLR 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  255 NNKTLTLCFEKLPDRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLYYSQDQSNIIRAQLLEKN 334
Cdd:COG5076 161 DGRFLSSIFLGLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVYVDAKELEKY 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  335 FNRLVR-IELSKPDEDYLPEGELRYPLDDVEINDEKYQIGDWVLLHNPNDINKPIVGQIFRLWSTTDGNKWLNACWYFRP 413
Cdd:COG5076 241 FLKLIEeIPEEMLELSIKPGREEREERESVLITNSQAHVGAWPFLRPVSDEEVPDYYKDIRDPMDLSTKELKLRNNYYRP 320

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|
gi 6321493  414 EQTVHRVDRLFYKNEVMKTGQYRDHPIQDIKGKCYVIHFTRFQRGDPSTK 463
Cdd:COG5076 321 EETFVRDAKLFFDNCVMYNGEVTDYYKNANVLEDFVIKKTRLIREYPKLI 370
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 8-113 1.48e-55

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99952  Cd Length: 106  Bit Score: 187.14  E-value: 1.48e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493    8 FLQKLLKTQYDAVFHLKDENGIEIYPIFNVLPPKKEYPDYYIIIRNPISLNTLKKRLPHYTSPQDFVNDFAQIPWNAMTY 87
Cdd:cd05521   1 KLSKKLKPLYDGIYTLKEENGIEIHPIFNVLPLRKDYPDYYKIIKNPLSLNTVKKRLPHYTNAQEFVNDLAQIPWNARLY 80

                        90       100
                ....*....|....*....|....*.
gi 6321493   88 NAKDSVIYKYAILLESFIKGKIVHNI 113
Cdd:cd05521  81 NTKGSVIYKYALILEKYINDVIIPNL 106
BAH_polybromo cd04717
BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human ...
 367-487 1.21e-51

BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional regulation. Saccharomyces cerevisiae RSC1 and RSC2 are part of the 15-subunit nucleosome remodeling RSC complex. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.


Pssm-ID: 240068  Cd Length: 121  Bit Score: 176.62  E-value: 1.21e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  367 DEKYQIGDWVLLHNPNDINKPIVGQIFRLWSTTDGNKWLNACWYFRPEQTVHRVDRLFYKNEVMKTGQYRDHPIQDIKGK 446
Cdd:cd04717   1 GLQYRVGDCVYVANPEDPSKPIIFRIERLWKDEDGEKFFFGCWFYRPEETFHEPTRKFYKNEVFKSPLYETVPVEEIVGK 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 6321493  447 CYVIHFTRFQRGDPSTKVNGPQFVCEFRYNESDKVFNKIRT 487
Cdd:cd04717  81 CAVMDVKDYIKGRPTEISEEDVYVCESRYNESAKSFKKIKT 121
BAH pfam01426
BAH domain; This domain has been called BAH (Bromo adjacent homology) domain and has also been ...
 368-486 7.14e-43

BAH domain; This domain has been called BAH (Bromo adjacent homology) domain and has also been called ELM1 and BAM (Bromo adjacent motif) domain. The function of this domain is unknown but may be involved in protein-protein interaction.


Pssm-ID: 460207  Cd Length: 120  Bit Score: 151.69  E-value: 7.14e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493    368 EKYQIGDWVLLHNPNDINKPIVGQIFRLWSTTDGN-KWLNACWYFRPEQTVHRVDRLFYKNEVMKTGQYRDHPIQDIKGK 446
Cdd:pfam01426   1 ETYSVGDFVLVEPDDADEPYYVARIEELFEDTKNGkKMVRVQWFYRPEETVHRAGKAFNKDELFLSDEEDDVPLSAIIGK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 6321493    447 CYVIHFTRFQRGDPSTKVNGPQFVCEFRYNESDKVFNKIR 486
Cdd:pfam01426  81 CSVLHKSDLESLDPYKIKEPDDFFCELLYDPKTKSFKKLP 120
BAH smart00439
Bromo adjacent homology domain;
369-486 9.01e-34

Bromo adjacent homology domain;


Pssm-ID: 214664 [Multi-domain]  Cd Length: 121  Bit Score: 125.87  E-value: 9.01e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493     369 KYQIGDWVLLHNPNDINKPIVGQIFRLWSTTDGN--KWLNACWYFRPEQTVHRVDRLFYKNEVMKTGQYRDHPIQDIKGK 446
Cdd:smart00439   1 TISVGDFVLVEPDDADEPYYIGRIEEIFETKKNSesKMVRVRWFYRPEETVLEKAALFDKNEVFLSDEYDTVPLSDIIGK 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 6321493     447 CYVIHFTRFQRGDPSTKVNGP-QFVCEFRYNESDKVFNKIR 486
Cdd:smart00439  81 CNVLYKSDYPGLRPEGSIGEPdVFFCESAYDPEKGSFKKLP 121
BROMO smart00297
bromo domain;
9-109 6.99e-27

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 105.44  E-value: 6.99e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493       9 LQKLLKTQYDAVFHLKDENgiEIYPIFNVLPPKKEYPDYYIIIRNPISLNTLKKRLP--HYTSPQDFVNDFAQIPWNAMT 86
Cdd:smart00297   4 LQKKLQELLKAVLDKLDSH--PLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLEngKYSSVEEFVADFNLMFSNART 81

                           90       100
                   ....*....|....*....|...
gi 6321493      87 YNAKDSVIYKYAILLESFIKGKI 109
Cdd:smart00297  82 YNGPDSEVYKDAKKLEKFFEKKL 104
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 30-98 3.25e-15

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 71.58  E-value: 3.25e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6321493     30 EIYPIFNVLPPKKEYPDYYIIIRNPISLNTLKKRL--PHYTSPQDFVNDFAQIPWNAMTYNAKDSVIYKYA 98
Cdd:pfam00439  12 PIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLenGEYKSLAEFLADVKLIFSNARTYNGPGSVIYKAA 82
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 10-145 1.76e-12

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 70.22  E-value: 1.76e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493   10 QKLLKTQYDAVFHLK----DENGIEIYPIFNVLPPKKEYPDYYIIIRNPISLNTLKKRLPH--YTSPQDFVNDFAQIPWN 83
Cdd:COG5076 140 DELLYADNKAIAKFKkqlfLRDGRFLSSIFLGLPSKREYPDYYEIIKSPMDLLTIQKKLKNgrYKSFEEFVSDLNLMFDN 219

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6321493   84 AMTYNAKDSVIYKYAILLESFIK---GKIVHNIRKHYPEvtypsLGRIPEIFAESMQPSDLSSNP 145
Cdd:COG5076 220 CKLYNGPDSSVYVDAKELEKYFLkliEEIPEEMLELSIK-----PGREEREERESVLITNSQAHV 279
 
Name Accession Description Interval E-value
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 115-463 2.09e-88

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 286.70  E-value: 2.09e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  115 KHYPEVTYPSLGRIP----EIFAESMQPSDLSSNPI-NTQENDEKAGLNP-EMKMAFAKLDSSIT-ERKPT-----NQDY 182
Cdd:COG5076   1 LEFDEVSYSQLGRPSvlkeEFGNELLRLVDNDSSPFpNAPEEEGSKNLFQkQLKRMPKEYITSIVdDREPGsmanvNDDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  183 RMQQKN--SPAF-----PTHSASITPQPLASPTPVVNYANITSAHPKT-HVRRGRPPVIDLPYVLRIKNILKMMRREVDQ 254
Cdd:COG5076  81 ENVGGItySPFEknrpeSLRFDEIVFLAIESVTPESGLGSLLMAHLKTsVKKRKTPKIEDELLYADNKAIAKFKKQLFLR 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  255 NNKTLTLCFEKLPDRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLYYSQDQSNIIRAQLLEKN 334
Cdd:COG5076 161 DGRFLSSIFLGLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVYVDAKELEKY 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  335 FNRLVR-IELSKPDEDYLPEGELRYPLDDVEINDEKYQIGDWVLLHNPNDINKPIVGQIFRLWSTTDGNKWLNACWYFRP 413
Cdd:COG5076 241 FLKLIEeIPEEMLELSIKPGREEREERESVLITNSQAHVGAWPFLRPVSDEEVPDYYKDIRDPMDLSTKELKLRNNYYRP 320

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|
gi 6321493  414 EQTVHRVDRLFYKNEVMKTGQYRDHPIQDIKGKCYVIHFTRFQRGDPSTK 463
Cdd:COG5076 321 EETFVRDAKLFFDNCVMYNGEVTDYYKNANVLEDFVIKKTRLIREYPKLI 370
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 8-113 1.48e-55

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99952  Cd Length: 106  Bit Score: 187.14  E-value: 1.48e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493    8 FLQKLLKTQYDAVFHLKDENGIEIYPIFNVLPPKKEYPDYYIIIRNPISLNTLKKRLPHYTSPQDFVNDFAQIPWNAMTY 87
Cdd:cd05521   1 KLSKKLKPLYDGIYTLKEENGIEIHPIFNVLPLRKDYPDYYKIIKNPLSLNTVKKRLPHYTNAQEFVNDLAQIPWNARLY 80

                        90       100
                ....*....|....*....|....*.
gi 6321493   88 NAKDSVIYKYAILLESFIKGKIVHNI 113
Cdd:cd05521  81 NTKGSVIYKYALILEKYINDVIIPNL 106
BAH_polybromo cd04717
BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human ...
 367-487 1.21e-51

BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional regulation. Saccharomyces cerevisiae RSC1 and RSC2 are part of the 15-subunit nucleosome remodeling RSC complex. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.


Pssm-ID: 240068  Cd Length: 121  Bit Score: 176.62  E-value: 1.21e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  367 DEKYQIGDWVLLHNPNDINKPIVGQIFRLWSTTDGNKWLNACWYFRPEQTVHRVDRLFYKNEVMKTGQYRDHPIQDIKGK 446
Cdd:cd04717   1 GLQYRVGDCVYVANPEDPSKPIIFRIERLWKDEDGEKFFFGCWFYRPEETFHEPTRKFYKNEVFKSPLYETVPVEEIVGK 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 6321493  447 CYVIHFTRFQRGDPSTKVNGPQFVCEFRYNESDKVFNKIRT 487
Cdd:cd04717  81 CAVMDVKDYIKGRPTEISEEDVYVCESRYNESAKSFKKIKT 121
Bromo_Rsc1_2_II cd05522
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 236-339 1.12e-48

Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99953 [Multi-domain]  Cd Length: 104  Bit Score: 167.42  E-value: 1.12e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  236 PYVLRIKNILKMMRREVDQNNKTLTLCFEKLPDRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFK 315
Cdd:cd05522   1 PYEARIKNILKGLRKERDENGRLLTLHFEKLPDKAREPEYYQEISNPISLDDIKKKVKRRKYKSFDQFLNDLNLMFENAK 80

                        90       100
                ....*....|....*....|....
gi 6321493  316 LYYSQDQSNIIRAQLLEKNFNRLV 339
Cdd:cd05522  81 LYNENDSQEYKDAVLLEKEARLLA 104
BAH pfam01426
BAH domain; This domain has been called BAH (Bromo adjacent homology) domain and has also been ...
 368-486 7.14e-43

BAH domain; This domain has been called BAH (Bromo adjacent homology) domain and has also been called ELM1 and BAM (Bromo adjacent motif) domain. The function of this domain is unknown but may be involved in protein-protein interaction.


Pssm-ID: 460207  Cd Length: 120  Bit Score: 151.69  E-value: 7.14e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493    368 EKYQIGDWVLLHNPNDINKPIVGQIFRLWSTTDGN-KWLNACWYFRPEQTVHRVDRLFYKNEVMKTGQYRDHPIQDIKGK 446
Cdd:pfam01426   1 ETYSVGDFVLVEPDDADEPYYVARIEELFEDTKNGkKMVRVQWFYRPEETVHRAGKAFNKDELFLSDEEDDVPLSAIIGK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 6321493    447 CYVIHFTRFQRGDPSTKVNGPQFVCEFRYNESDKVFNKIR 486
Cdd:pfam01426  81 CSVLHKSDLESLDPYKIKEPDDFFCELLYDPKTKSFKKLP 120
BAH smart00439
Bromo adjacent homology domain;
369-486 9.01e-34

Bromo adjacent homology domain;


Pssm-ID: 214664 [Multi-domain]  Cd Length: 121  Bit Score: 125.87  E-value: 9.01e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493     369 KYQIGDWVLLHNPNDINKPIVGQIFRLWSTTDGN--KWLNACWYFRPEQTVHRVDRLFYKNEVMKTGQYRDHPIQDIKGK 446
Cdd:smart00439   1 TISVGDFVLVEPDDADEPYYIGRIEEIFETKKNSesKMVRVRWFYRPEETVLEKAALFDKNEVFLSDEYDTVPLSDIIGK 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 6321493     447 CYVIHFTRFQRGDPSTKVNGP-QFVCEFRYNESDKVFNKIR 486
Cdd:smart00439  81 CNVLYKSDYPGLRPEGSIGEPdVFFCESAYDPEKGSFKKLP 121
BROMO smart00297
bromo domain;
9-109 6.99e-27

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 105.44  E-value: 6.99e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493       9 LQKLLKTQYDAVFHLKDENgiEIYPIFNVLPPKKEYPDYYIIIRNPISLNTLKKRLP--HYTSPQDFVNDFAQIPWNAMT 86
Cdd:smart00297   4 LQKKLQELLKAVLDKLDSH--PLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLEngKYSSVEEFVADFNLMFSNART 81

                           90       100
                   ....*....|....*....|...
gi 6321493      87 YNAKDSVIYKYAILLESFIKGKI 109
Cdd:smart00297  82 YNGPDSEVYKDAKKLEKFFEKKL 104
BROMO smart00297
bromo domain;
241-342 1.49e-23

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 96.19  E-value: 1.49e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493     241 IKNILKMMRREVDqnNKTLTLCFEKLPDRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLYYSQ 320
Cdd:smart00297   8 LQELLKAVLDKLD--SHPLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTYNGP 85

                           90       100
                   ....*....|....*....|..
gi 6321493     321 DQSNIIRAQLLEKNFNRLVRIE 342
Cdd:smart00297  86 DSEVYKDAKKLEKFFEKKLREL 107
Bromo_SNF2 cd05519
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in ...
 9-109 2.73e-22

Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99950  Cd Length: 103  Bit Score: 92.40  E-value: 2.73e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493    9 LQKLLKTQYDAVFHLKDENGIEIYPIFNVLPPKKEYPDYYIIIRNPISLNTLKKRLP--HYTSPQDFVNDFAQIPWNAMT 86
Cdd:cd05519   1 LKAAMLEIYDAVLNCEDETGRKLSELFLEKPSKKLYPDYYVIIKRPIALDQIKRRIEgrAYKSLEEFLEDFHLMFANART 80

                        90       100
                ....*....|....*....|...
gi 6321493   87 YNAKDSVIYKYAILLESFIKGKI 109
Cdd:cd05519  81 YNQEGSIVYEDAVEMEKAFKKKY 103
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 9-109 3.06e-22

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 92.05  E-value: 3.06e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493    9 LQKLLKTQYDAVFHLKDEngieIYPIFNVLPPKKEYPDYYIIIRNPISLNTLKKRLP--HYTSPQDFVNDFAQIPWNAMT 86
Cdd:cd04369   1 LKKKLRSLLDALKKLKRD----LSEPFLEPVDPKEAPDYYEVIKNPMDLSTIKKKLKngEYKSLEEFEADVRLIFSNAKT 76

                        90       100
                ....*....|....*....|...
gi 6321493   87 YNAKDSVIYKYAILLESFIKGKI 109
Cdd:cd04369  77 YNGPGSPIYKDAKKLEKLFEKLL 99
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 9-105 1.52e-19

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 84.66  E-value: 1.52e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493    9 LQKLLKTQYDAVFHLKDENGIEIYPIFNVLPPKKEYPDYYIIIRNPISLNTLKKRLP--HYTSPQDFVNDFAQIPWNAMT 86
Cdd:cd05515   1 MQQKLWELYNAVKNYTDGRGRRLSLIFMRLPSKSEYPDYYDVIKKPIDMEKIRSKIEgnQYQSLDDMVSDFVLMFDNACK 80

                        90
                ....*....|....*....
gi 6321493   87 YNAKDSVIYKYAILLESFI 105
Cdd:cd05515  81 YNEPDSQIYKDALTLQKVL 99
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 41-109 1.65e-17

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 78.75  E-value: 1.65e-17
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6321493   41 KKEYPDYYIIIRNPISLNTLKKRLP--HYTSPQDFVNDFAQIPWNAMTYNAKDSVIYKYAILLESFIKGKI 109
Cdd:cd05509  28 KEEAPDYYDVIKKPMDLSTMEEKLEngYYVTLEEFVADLKLIFDNCRLYNGPDTEYYKCANKLEKFFWKKL 98
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 9-108 2.74e-17

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 78.26  E-value: 2.74e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493    9 LQKLLKTQYDAVFHLKDENGIEIYPIFNVLPPKKEYPDYYIIIRNPISLNTLKK--RLPHYTSPQDFVNDFAQIPWNAMT 86
Cdd:cd05518   1 RKKRMLALFLYVLEYREGSGRRLCDLFMEKPSKKDYPDYYKIILEPIDLKTIEHniRNDKYATEEELMDDFKLMFRNARH 80

                        90       100
                ....*....|....*....|..
gi 6321493   87 YNAKDSVIYKYAILLESFIKGK 108
Cdd:cd05518  81 YNEEGSQVYEDANILEKVLKEK 102
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 241-339 3.91e-17

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 77.41  E-value: 3.91e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  241 IKNILKMMRREVDQNNKTLTLCFEKLPDRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLYYSQ 320
Cdd:cd04369   1 LKKKLRSLLDALKKLKRDLSEPFLEPVDPKEAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNGP 80

                        90
                ....*....|....*....
gi 6321493  321 DQSNIIRAQLLEKNFNRLV 339
Cdd:cd04369  81 GSPIYKDAKKLEKLFEKLL 99
BAH cd04370
BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). ...
 368-485 1.11e-16

BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in mammalian DNA methyltransferases and the MTA1 subunits of histone deacetylase complexes. A BAH domain is also found in Yeast Sir3p and in the origin receptor complex protein 1 (Orc1p), where it was found to interact with the N-terminal lobe of the silence information regulator 1 protein (Sir1p), confirming the initial hypothesis that BAH plays a role in protein-protein interactions.


Pssm-ID: 239835 [Multi-domain]  Cd Length: 123  Bit Score: 77.05  E-value: 1.11e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  368 EKYQIGDWVLLHN--PNDINKPIVGQIFRLWSTTDGNKWLNACWYFRPEQTVHRVDRLFYKNEVMKTGQYRDHPIQDIKG 445
Cdd:cd04370   2 ITYEVGDSVYVEPddSIKSDPPYIARIEELWEDTNGSKQVKVRWFYRPEETPKGLSPFALRRELFLSDHLDEIPVESIIG 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 6321493  446 KCYVIHFTRFQRGDPSTKV-NGPQFVCEFRYNESDKVFNKI 485
Cdd:cd04370  82 KCKVLFVSEFEGLKQRPNKiDTDDFFCRLAYDPTTKEFKAL 122
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 30-98 3.25e-15

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 71.58  E-value: 3.25e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6321493     30 EIYPIFNVLPPKKEYPDYYIIIRNPISLNTLKKRL--PHYTSPQDFVNDFAQIPWNAMTYNAKDSVIYKYA 98
Cdd:pfam00439  12 PIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLenGEYKSLAEFLADVKLIFSNARTYNGPGSVIYKAA 82
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 9-107 3.67e-15

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 72.08  E-value: 3.67e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493    9 LQKLLKTQYDAVFHLKDENGIEIYPIFNVLPPKKEYPDYYIIIRNPISLNTLKKRLPH--YTSPQDFVNDFAQIPWNAMT 86
Cdd:cd05516   2 LTKKMNKIVDVVIKYKDSDGRQLAEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNhkYRSLEDLEKDVMLLCQNAQT 81

                        90       100
                ....*....|....*....|.
gi 6321493   87 YNAKDSVIYKYAILLESFIKG 107
Cdd:cd05516  82 FNLEGSLIYEDSIVLQSVFKS 102
Bromo_Rsc1_2_II cd05522
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 23-102 2.08e-13

Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99953 [Multi-domain]  Cd Length: 104  Bit Score: 66.88  E-value: 2.08e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493   23 LKDENGIEIYPIFNVLPPKKEYPDYYIIIRNPISLNTLKKRLP--HYTSPQDFVNDFAQIPWNAMTYNAKDSVIYKYAIL 100
Cdd:cd05522  16 ERDENGRLLTLHFEKLPDKAREPEYYQEISNPISLDDIKKKVKrrKYKSFDQFLNDLNLMFENAKLYNENDSQEYKDAVL 95


                ..
gi 6321493  101 LE 102
Cdd:cd05522  96 LE 97
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 39-119 3.77e-13

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 66.55  E-value: 3.77e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493   39 PPKKEYPDYYIIIRNPISLNTLKKRL-----PHYTSPQDFVNDFAQIPWNAMTYNAKDSVIYKYAILLESFIKGKivhnI 113
Cdd:cd05502  28 PVSPSVPNYYKIIKTPMDLSLIRKKLqpkspQHYSSPEEFVADVRLMFKNCYKFNEEDSEVAQAGKELELFFEEQ----L 103


                ....*.
gi 6321493  114 RKHYPE 119
Cdd:cd05502 104 KEILPD 109
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 262-321 8.91e-13

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 64.64  E-value: 8.91e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493    262 CFEKLPDRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLYYSQD 321
Cdd:pfam00439  16 PFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPG 75
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 248-321 1.39e-12

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 65.05  E-value: 1.39e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6321493  248 MRREVDQNNKTLTLCFEKLPDRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLYYSQD 321
Cdd:cd05524  14 IRNYKSEDGRILCESFIRVPKRRNEPEYYEVVSNPIDLLKIQQKLKTEEYDDVDDLTADFELLINNAKAYYKPD 87
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 9-117 1.48e-12

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 64.72  E-value: 1.48e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493    9 LQKLLKTQYDAVFHLKDENGIEIYPIFNVLPPKKEYPDYYIIIRNPISLNTLKKRL--PHYTSPQDFVNDFAQIPWNAMT 86
Cdd:cd05525   3 LAQVLKEICDAIITYKDSNGQSLAIPFINLPSKKKNPDYYERITDPVDLSTIEKQIltGYYKTPEAFDSDMLKVFRNAEK 82

                        90       100       110
                ....*....|....*....|....*....|.
gi 6321493   87 YNAKDSVIykyaillesfikGKIVHNIRKHY 117
Cdd:cd05525  83 YYGRKSPI------------GRDVCRLRKAY 101
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 10-145 1.76e-12

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 70.22  E-value: 1.76e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493   10 QKLLKTQYDAVFHLK----DENGIEIYPIFNVLPPKKEYPDYYIIIRNPISLNTLKKRLPH--YTSPQDFVNDFAQIPWN 83
Cdd:COG5076 140 DELLYADNKAIAKFKkqlfLRDGRFLSSIFLGLPSKREYPDYYEIIKSPMDLLTIQKKLKNgrYKSFEEFVSDLNLMFDN 219

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6321493   84 AMTYNAKDSVIYKYAILLESFIK---GKIVHNIRKHYPEvtypsLGRIPEIFAESMQPSDLSSNP 145
Cdd:COG5076 220 CKLYNGPDSSVYVDAKELEKYFLkliEEIPEEMLELSIK-----PGREEREERESVLITNSQAHV 279
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 9-108 5.52e-12

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 62.84  E-value: 5.52e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493    9 LQKLLKTQYDAVFHLKDENGIEIYPIFNVLPPKKEYPDYYIIIRNPISLNTLKKRL--PHYTSPQDFVNDFAQIPWNAMT 86
Cdd:cd05517   1 LKQILEQLLEAVMTATDPSGRLISELFQKLPSKVLYPDYYAVIKEPIDLKTIAQRIqsGYYKSIEDMEKDLDLMVKNAKT 80

                        90       100
                ....*....|....*....|..
gi 6321493   87 YNAKDSVIYKYAILLESFIKGK 108
Cdd:cd05517  81 FNEPGSQVYKDANAIKKIFTAK 102
BAH_BAHCC1 cd04714
BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. ...
 367-475 5.92e-12

BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.


Pssm-ID: 240065  Cd Length: 121  Bit Score: 63.57  E-value: 5.92e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  367 DEKYQIGDWVLLHNPNDINKPIVGQIFRLWSTTDGNKWLNACWYFRPEQTVHRVDRLFYKNEVMKTgQYRDH-PIQDIKG 445
Cdd:cd04714   1 KEIIRVGDCVLFKSPGRPSLPYVARIESLWEDPEGNMVVRVKWYYRPEETKGGRKPNHGEKELFAS-DHQDEnSVQTIEH 79

                        90       100       110
                ....*....|....*....|....*....|
gi 6321493  446 KCYVIHFTRFQRGDPSTKVngPQFVCEFRY 475
Cdd:cd04714  80 KCYVLTFAEYERLARVKKK--PQDGVDFYY 107
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 240-333 7.01e-12

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 62.85  E-value: 7.01e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  240 RIKNILKMMRREVDQNNKTLTLCFEKLPDRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKlYYS 319
Cdd:cd05518   4 RMLALFLYVLEYREGSGRRLCDLFMEKPSKKDYPDYYKIILEPIDLKTIEHNIRNDKYATEEELMDDFKLMFRNAR-HYN 82

                        90
                ....*....|....*
gi 6321493  320 QDQSNIIR-AQLLEK 333
Cdd:cd05518  83 EEGSQVYEdANILEK 97
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 268-340 1.22e-11

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 61.80  E-value: 1.22e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6321493  268 DRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLYYSQDQSNIIRAQLLEKNFNRLVR 340
Cdd:cd05509  27 DKEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPDTEYYKCANKLEKFFWKKLK 99
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 240-313 1.53e-11

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 61.94  E-value: 1.53e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6321493  240 RIKNILKMMRREVDQNNKTLTLCFEKLPDRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTN 313
Cdd:cd05515   4 KLWELYNAVKNYTDGRGRRLSLIFMRLPSKSEYPDYYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDN 77
Bromo_SNF2 cd05519
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in ...
 253-336 1.79e-11

Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99950  Cd Length: 103  Bit Score: 61.59  E-value: 1.79e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  253 DQNNKTLTLCFEKLPDRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLyYSQDQSNIIR-AQLL 331
Cdd:cd05519  17 DETGRKLSELFLEKPSKKLYPDYYVIIKRPIALDQIKRRIEGRAYKSLEEFLEDFHLMFANART-YNQEGSIVYEdAVEM 95


                ....*
gi 6321493  332 EKNFN 336
Cdd:cd05519  96 EKAFK 100
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 240-317 1.95e-10

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 58.59  E-value: 1.95e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6321493  240 RIKNILKMMRREVDQNNKTLTLCFEKLPDRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLY 317
Cdd:cd05516   5 KMNKIVDVVIKYKDSDGRQLAEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLEDLEKDVMLLCQNAQTF 82
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 241-335 6.99e-10

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 57.01  E-value: 6.99e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  241 IKNILKMMRREVDQNNKTLTLCFEKLPDRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLYYSQ 320
Cdd:cd05525   7 LKEICDAIITYKDSNGQSLAIPFINLPSKKKNPDYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFRNAEKYYGR 86

                        90
                ....*....|....*
gi 6321493  321 DQSNIIRAQLLEKNF 335
Cdd:cd05525  87 KSPIGRDVCRLRKAY 101
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 17-108 2.28e-09

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 55.42  E-value: 2.28e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493   17 YDAVFHLKDENGIEIYPIFNVLPPKKEYPDYYIIIRNPISLNTLKKRLPH--YTSPQDFVNDFAQIPWNAMTYNAKDSVI 94
Cdd:cd05520   9 YDTIRNARNNQGQLLAEPFLKLPSKRKYPDYYQEIKNPISLQQIRTKLKNgeYETLEELEADLNLMFENAKRYNVPNSRI 88

                        90
                ....*....|....
gi 6321493   95 YKYAILLESFIKGK 108
Cdd:cd05520  89 YKDAEKLQKLMQAK 102
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 249-333 2.31e-09

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 55.42  E-value: 2.31e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  249 RREVDQNNKTLTLCFEKLPDRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLYYSQDQSNIIRA 328
Cdd:cd05520  13 RNARNNQGQLLAEPFLKLPSKRKYPDYYQEIKNPISLQQIRTKLKNGEYETLEELEADLNLMFENAKRYNVPNSRIYKDA 92


                ....*
gi 6321493  329 QLLEK 333
Cdd:cd05520  93 EKLQK 97
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 34-104 3.68e-09

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 54.64  E-value: 3.68e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493   34 IFN--VLPPKKEYPDYYIIIRNPISLNTLKKRLP--HYTSPQDFVND----FAqipwNAMTYNAKDSVIYKYAI-LLESF 104
Cdd:cd05506  20 VFNapVDVVALGLPDYFDIIKKPMDLGTVKKKLEkgEYSSPEEFAADvrltFA----NAMRYNPPGNDVHTMAKeLLKIF 95
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 37-104 5.11e-09

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 54.59  E-value: 5.11e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493   37 VLPPKKEYPDYYIIIRNPISLNTLKKRLPH--YTSPQDFVNDFAQIPWNAMTYNAKDSVIYKYAILLESF 104
Cdd:cd05498  28 VDPEALGLHDYHDIIKHPMDLSTIKKKLDNreYADAQEFAADVRLMFSNCYKYNPPDHPVHAMARKLQDV 97
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 253-317 6.59e-09

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 54.37  E-value: 6.59e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6321493  253 DQNNKTLTLCFEKLPDRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLY 317
Cdd:cd05517  17 DPSGRLISELFQKLPSKVLYPDYYAVIKEPIDLKTIAQRIQSGYYKSIEDMEKDLDLMVKNAKTF 81
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 37-110 8.22e-09

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 53.99  E-value: 8.22e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6321493   37 VLPPKKEYPDYYIIIRNPISLNTLKKRLP--HYTSPQDFVNDFAQIPWNAMTYNAKDSVIYKYAILLESFIKGKIV 110
Cdd:cd05495  29 VDPKLLGIPDYFDIVKNPMDLSTIRRKLDtgQYQDPWQYVDDVWLMFDNAWLYNRKTSRVYKYCTKLAEVFEQEID 104
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 9-101 9.99e-09

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 53.56  E-value: 9.99e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493    9 LQKLLKTQYDAVfHLKDENGIEIYPIfnvlpPKKEYPDYYIIIRNPISLNTLKKRLP--HYTSPQDFVNDFAQIPWNAMT 86
Cdd:cd05512   2 LEVLLRKTLDQL-QEKDTAEIFSEPV-----DLSEVPDYLDHIKQPMDFSTMRKKLEsqRYRTLEDFEADFNLIINNCLA 75

                        90
                ....*....|....*
gi 6321493   87 YNAKDSVIYKYAILL 101
Cdd:cd05512  76 YNAKDTIFYRAAVRL 90
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 37-103 1.05e-08

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 53.47  E-value: 1.05e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6321493   37 VLPPKKEYPDYYIIIRNPISLNTLKKRLPH--YTSPQDFVNDFAQIPWNAMTYNAKDSVIYKYAILLES 103
Cdd:cd05500  29 VDPVKLNIPHYPTIIKKPMDLGTIERKLKSnvYTSVEEFTADFNLMVDNCLTFNGPEHPVSQMGKRLQA 97
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 17-108 1.31e-08

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 53.49  E-value: 1.31e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493   17 YDAVFHLKDENGIEIYPIFNVLPPKKEYPDYYIIIRNPISLNTLKKRL--PHYTSPQDFVNDFAQIPWNAMTYNAKDSVI 94
Cdd:cd05524  11 YDTIRNYKSEDGRILCESFIRVPKRRNEPEYYEVVSNPIDLLKIQQKLktEEYDDVDDLTADFELLINNAKAYYKPDSPE 90

                        90
                ....*....|....*
gi 6321493   95 YKYAI-LLESFIKGK 108
Cdd:cd05524  91 HKDACkLWELFLSAR 105
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 273-342 3.05e-08

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 52.65  E-value: 3.05e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6321493  273 PTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLYYSQDQSNIIRAQ--------LLEKNFNRLVRIE 342
Cdd:cd05511  31 PDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPDSVYTKKAKemlelaeeLLAEREEKLTQLE 108
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 35-104 3.43e-08

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 52.40  E-value: 3.43e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6321493   35 FNVLPPKKEYPDYYIIIRNPISLNTLKKRLPH--YTSPQDFVNDFAQIPWNAMTYNAKDSVIYKYAILLESF 104
Cdd:cd05504  33 FLRPVSKIEVPDYYDIIKKPMDLGTIKEKLNMgeYKLAEEFLSDIQLVFSNCFLYNPEHTSVYKAGTRLQRF 104
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 41-98 4.59e-08

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 51.88  E-value: 4.59e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493   41 KKEYPDYYIIIRNPISLNTLKKRLPH--YTSPQDFVNDFAQIPWNAMTYNAKDSVIYKYA 98
Cdd:cd05511  27 KKKVPDYYKIIKRPMDLQTIRKKISKhkYQSREEFLEDIELIVDNSVLYNGPDSVYTKKA 86
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 45-116 4.62e-08

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 51.64  E-value: 4.62e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6321493   45 PDYYIIIRNPISLNTLKKRLP--HYTSPQDFVNDFAQIPWNAMTYNAKDSVIYKYAillesfikGKIVHNIRKH 116
Cdd:cd05513  32 PGYSSIIKHPMDFSTMKEKIKnnDYQSIEEFKDDFKLMCENAMKYNKPDTIYYKAA--------KKLLHSGMKI 97
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 41-109 1.00e-07

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 50.88  E-value: 1.00e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6321493   41 KKEYPDYYIIIRNPISLNTLKKRLP--HYTSPQDFVNDFAQIPWNAMTYNAKDSVIYKYAILLESFIKGKI 109
Cdd:cd05497  34 KLNLPDYHKIIKTPMDLGTIKKRLEnnYYWSASECIQDFNTMFTNCYIYNKPGDDVVLMAQTLEKLFLQKL 104
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 267-338 2.18e-07

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 49.98  E-value: 2.18e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6321493  267 PDRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTN-FKLYYSQDQSNIIrAQLLEKNFNRL 338
Cdd:cd05499  30 PVALNIPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNcYTFNPEGTDVYMM-GHQLEEVFNDK 101
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 30-102 2.58e-07

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 50.41  E-value: 2.58e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6321493   30 EIYPIF-NVLPPKKEYPDYYIIIRNPISLNTLKKRLPH--YTSPQDFVNDFAQIPWNAMTYNAKDSVIYKYAILLE 102
Cdd:cd05529  43 EIAEYFeYPVDLRAWYPDYWNRVPVPMDLETIRSRLENryYRSLEALRHDVRLILSNAETFNEPNSEIAKKAKRLS 118
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 41-92 4.26e-07

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 49.36  E-value: 4.26e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 6321493   41 KKEYPDYYIIIRNPISLNTLKKRLP--HYTSPQDFVNDFAQIPWNAMTYNAKDS 92
Cdd:cd05510  35 KREAPDYYDIIKKPMDLGTMLKKLKnlQYKSKAEFVDDLNLIWKNCLLYNSDPS 88
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 268-321 5.48e-07

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 48.55  E-value: 5.48e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 6321493  268 DRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLYYSQD 321
Cdd:cd05512  27 DLSEVPDYLDHIKQPMDFSTMRKKLESQRYRTLEDFEADFNLIINNCLAYNAKD 80
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 263-340 1.84e-06

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 47.44  E-value: 1.84e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  263 FEKLPDRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFkLYYSQDQSNIIR--AQLLEKNFNRLVR 340
Cdd:cd05510  29 FLTKVSKREAPDYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDLNLIWKNC-LLYNSDPSHPLRrhANFMKKKAEHLLK 107
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 273-337 2.67e-06

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 46.92  E-value: 2.67e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6321493  273 PTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLYYSQDQSNIIRAQLLEKNFNR 337
Cdd:cd05500  37 PHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDNCLTFNGPEHPVSQMGKRLQAAFEK 101
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 42-117 3.00e-06

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 46.60  E-value: 3.00e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6321493   42 KEYPDYYIIIRNPISLNTLKKRLPH--YTSPQDFVNDFAQIPWNAMTYNAKDSVIykyaillesfikGKIVHNIRKHY 117
Cdd:cd05503  28 KLVPGYRKIIKKPMDFSTIREKLESgqYKTLEEFAEDVRLVFDNCETFNEDDSEV------------GRAGHNMRKFF 93
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 253-333 3.30e-06

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99952  Cd Length: 106  Bit Score: 46.55  E-value: 3.30e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  253 DQNNKTLTLCFEKLPDRNEEPTYYSVITDPICLMDIRKKVKsrKYRNFHTFEEDFQLMLTNFKLYYSQDQSNIIRAQLLE 332
Cdd:cd05521  18 EENGIEIHPIFNVLPLRKDYPDYYKIIKNPLSLNTVKKRLP--HYTNAQEFVNDLAQIPWNARLYNTKGSVIYKYALILE 95


                .
gi 6321493  333 K 333
Cdd:cd05521  96 K 96
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 263-323 9.70e-06

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 45.22  E-value: 9.70e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6321493  263 FEKLPDRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLYYSQDQS 323
Cdd:cd05505  21 FREPVTADEAEDYKKVITNPMDLQTMQTKCSCGSYSSVQEFLDDMKLVFSNAEKYYENGSY 81
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 43-109 1.80e-05

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 44.76  E-value: 1.80e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493   43 EYPDYYIIIRNPISLNTLKKRLP--HYTSPQDFVNDFAQIPWNAMTYNA-KDSVIYKYAILLESFIKGKI 109
Cdd:cd05496  34 KYPDYRDIIDTPMDLGTVKETLFggNYDDPMEFAKDVRLIFSNSKSYTPnKRSRIYSMTLRLSALFEEHI 103
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 43-88 1.97e-05

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 44.66  E-value: 1.97e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 6321493   43 EYPDYYIIIRNPISLNTLKKRLP--HYTSPQDFVNDFAQIPWNAMTYN 88
Cdd:cd05528  32 EVPDYYEIIKQPMDLQTILQKLDthQYLTAKDFLKDIDLIVTNALEYN 79
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 263-346 2.64e-05

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 44.31  E-value: 2.64e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  263 FEKLPDRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLyYSQDQSNIIRAQL-LEKNFNRLVRi 341
Cdd:cd05504  33 FLRPVSKIEVPDYYDIIKKPMDLGTIKEKLNMGEYKLAEEFLSDIQLVFSNCFL-YNPEHTSVYKAGTrLQRFFIKRCR- 110


                ....*
gi 6321493  342 ELSKP 346
Cdd:cd05504 111 KLGLP 115
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 45-108 5.50e-05

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 43.04  E-value: 5.50e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6321493   45 PDYYIIIRNPISLNTLKKRLPH--YTSPQDFVNDFAQIPWNAMTYNAKDSVIYKYAILLESFIKGK 108
Cdd:cd05499  36 PNYFSIIKKPMDLGTISKKLQNgqYQSAKEFERDVRLIFKNCYTFNPEGTDVYMMGHQLEEVFNDK 101
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 263-328 6.94e-05

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 43.11  E-value: 6.94e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6321493  263 FEKLPDRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLYYSQDQSNIIRA 328
Cdd:cd05528  24 FTKPVDEEEVPDYYEIIKQPMDLQTILQKLDTHQYLTAKDFLKDIDLIVTNALEYNPDRDPADKLI 89
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 273-317 1.16e-04

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 42.01  E-value: 1.16e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 6321493  273 PTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLY 317
Cdd:cd05513  32 PGYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMKY 76
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 39-94 1.22e-04

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 41.75  E-value: 1.22e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6321493   39 PPKKEYPDYYIIIRNPISLNTLKKRLP--HYTSPQDFVNDFAQIPWNAMTYNAKDSVI 94
Cdd:cd05505  25 VTADEAEDYKKVITNPMDLQTMQTKCScgSYSSVQEFLDDMKLVFSNAEKYYENGSYV 82
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 267-317 1.26e-04

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 42.05  E-value: 1.26e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 6321493  267 PDRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLY 317
Cdd:cd05495  31 PKLLGIPDYFDIVKNPMDLSTIRRKLDTGQYQDPWQYVDDVWLMFDNAWLY 81
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 273-335 1.74e-04

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 41.49  E-value: 1.74e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6321493  273 PTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLYYSQDQSNIIRAQLLEKNF 335
Cdd:cd05498  36 HDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKYNPPDHPVHAMARKLQDVF 98
Bromo_SP100C_like cd05501
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major ...
 263-341 2.98e-04

Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99933  Cd Length: 102  Bit Score: 40.87  E-value: 2.98e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  263 FEKLPDRNEEptYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLYYSQD---QSNIIRAQLLEKNFNRLV 339
Cdd:cd05501  23 FISKPYYIRD--YCQGIKEPMWLNKVKERLNERVYHTVEGFVRDMRLIFHNHKLFYKDDdfgQVGITLEKKFEKNFKEVF 100


                ..
gi 6321493  340 RI 341
Cdd:cd05501 101 AI 102
BAH_Orc1p_like cd04715
BAH, or Bromo Adjacent Homology domain, as present in the Schizosaccharomyces pombe homolog of ...
 366-460 4.86e-04

BAH, or Bromo Adjacent Homology domain, as present in the Schizosaccharomyces pombe homolog of Saccharomyces cerevisiae Orc1p and similar proteins. Orc1 is part of the Yeast Sir1-origin recognition complex, the Orc1p BAH doman functions in epigenetic silencing. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.


Pssm-ID: 240066  Cd Length: 159  Bit Score: 41.72  E-value: 4.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  366 NDEKYQIGDWVLLHNpnDINKPIVGQIFRLW--STTDGNKWLNACWYFRPEQT--VHRVDRLFYKNEVMKT-----GQYR 436
Cdd:cd04715  26 DGVEYRLYDDVYVHN--GDSEPYIGKIIKIYetAIDSGKKKVKVIWFFRPSEIrmELKGEPKRHINEVFLAcgrgeGLAN 103

                        90       100
                ....*....|....*....|....
gi 6321493  437 DHPIQDIKGKCYVIHFTRFQRGDP 460
Cdd:cd04715 104 INLLESIIGKCNVVCISEDFRNPQ 127
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 243-340 5.89e-04

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 40.78  E-value: 5.89e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  243 NILKMMRREVDQNNKTLTLCFE-KLPDRNEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLYYSQD 321
Cdd:cd05529  28 RLISGLDKLLLSLQLEIAEYFEyPVDLRAWYPDYWNRVPVPMDLETIRSRLENRYYRSLEALRHDVRLILSNAETFNEPN 107

                        90       100
                ....*....|....*....|
gi 6321493  322 qSNIIR-AQLLEKNFNRLVR 340
Cdd:cd05529 108 -SEIAKkAKRLSDWLLRILS 126
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 242-321 2.42e-03

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 38.50  E-value: 2.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  242 KNILKMMRREVDQNNKTLTLcfEKLPDRnEEPTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLYYSQD 321
Cdd:cd05507   6 KAILLVYRTLASHRYASVFL--KPVTED-IAPGYHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNSSD 82
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 273-335 3.98e-03

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 37.79  E-value: 3.98e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6321493  273 PTYYSVITDPICLMDIRKKVKSRKYRNFHTFEEDFQLMLTNFKLYYSQDQSNIIRAQLLEKNF 335
Cdd:cd05497  38 PDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCYIYNKPGDDVVLMAQTLEKLF 100
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 9-92 4.07e-03

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 37.75  E-value: 4.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493    9 LQKLLKTQYDAVFHLKDEngieiyPIFNVLPpKKEYPDYYIIIRNPISLNTLKK--RLPHYTSPQDFVNDFAQIPWNAMT 86
Cdd:cd05508   4 LSKLLKFALERMKQPGAE------PFLKPVD-LEQFPDYAQYVFKPMDLSTLEKnvRKKAYGSTDAFLADAKWILHNAII 76


                ....*.
gi 6321493   87 YNAKDS 92
Cdd:cd05508  77 YNGGDH 82
BAH_plant_3 cd04713
BAH, or Bromo Adjacent Homology domain, plant-specific sub-family with unknown function. BAH ...
 369-500 5.05e-03

BAH, or Bromo Adjacent Homology domain, plant-specific sub-family with unknown function. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.


Pssm-ID: 240064  Cd Length: 146  Bit Score: 38.60  E-value: 5.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321493  369 KYQIGDWVLLHnPNDINKPIVGQIFRLWSTTDGNKWLNACWYFRPEQTVHR---------VDRLFY---KNEVmktgqyr 436
Cdd:cd04713  20 KYRLEDCVLLV-PEDDQKPYIAIIKDIYKQEEGSLKLEVQWLYRPEEIEKKkggnwkaedPRELFYsfhRDEV------- 91

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6321493  437 dhPIQDIKGKCyVIHFTRFQRGDPSTKvNGPQFVCEFRYNESDKvfnkiRTWKaclpeeLRDQD 500
Cdd:cd04713  92 --PAESVLHPC-KVAFVPKGKQIPLRK-GHSGFIVRRVYDNVNK-----KLWK------LTDQD 140
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH