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Conserved domains on  [gi|6321531|ref|NP_011608|]
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valine--tRNA ligase [Saccharomyces cerevisiae S288C]

Protein Classification

valine--tRNA ligase( domain architecture ID 1000888)

valine--tRNA ligase catalyzes the attachment of valine to tRNA(Val)

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PTZ00419 super family cl36560
valyl-tRNA synthetase-like protein; Provisional
128-1104 0e+00

valyl-tRNA synthetase-like protein; Provisional


The actual alignment was detected with superfamily member PTZ00419:

Pssm-ID: 240411 [Multi-domain]  Cd Length: 995  Bit Score: 1327.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    128 KTVPGEKKILVSlddPALKAYNPANVESSWYDWWIKTGVFEPeFTADGKVKPEGVFCIPAPPPNVTGALHIGHALTIAIQ 207
Cdd:PTZ00419   11 KDEKKNKKRNIS---SMAASYDPKEVESGWYEWWEKSGFFKP-AEDAKSLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQ 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    208 DSLIRYNRMKGKTVLFLPGFDHAGIATQSVVEKQIWAKDRKTRHDYGREAFVGKVWEWKEEYHSRIKNQIQKLGASYDWS 287
Cdd:PTZ00419   87 DSLIRYHRMKGDETLWVPGTDHAGIATQVVVEKKLMKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWS 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    288 REAFTLSPELTKSVEEAFVRLHDEGVIYRASRLVNWSVKLNTAISNLEVENKDVKSRTLLSVPGYDEKVEFGVLTSFAYP 367
Cdd:PTZ00419  167 REVFTMDEQRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEKPTKITIPGYDKKVEVGVLWHFAYP 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    368 VIGSDE-KLIIATTRPETIFGDTAVAVHPDDDRYKHLHGKFIQHPFLP-RKIPIITDKEAVDMEFGTGAVKITPAHDQND 445
Cdd:PTZ00419  247 LEDSGQeEIVVATTRIETMLGDVAVAVHPKDERYKKLHGKELIHPFIPdRKIPIIADDELVDMEFGTGAVKITPAHDPND 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    446 YNTGKRHNLEFINILTDDGLLNEECGPeWQGMKRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDIIEPLLKPQWW 525
Cdd:PTZ00419  327 YEIAKRHNLPFINIFTLDGKINENGGE-FAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWY 405
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    526 VSQSEMAKDAIKVVRDGQITITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVYFINIEGEEHDRIDGDYWVAGRSMEE 605
Cdd:PTZ00419  406 VNCKDMAKRAVEAVRNGELKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYRVISKGPETDPSDEEPWVVARSEEE 485
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    606 AEKKAAAKYPNSK--FTLEQDEDVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFSMLETGWDILFFWVTRMILLGLKLTG 683
Cdd:PTZ00419  486 ALEKAKKKFGLSEedFELEQDEDVLDTWFSSGLFPFSTLGWPDQTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTD 565
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    684 SVPFKEVFCHSLVRDAQGRKMSKSLGNVIDPLDVITGIKLDDLHAKLLQGNLDPREVEKAKIGQKESYPNGIPQCGTDAM 763
Cdd:PTZ00419  566 KLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGISLQDLNQKLYEGNLPEKEIKRAIELQKKEFPNGIPECGTDAL 645
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    764 RFALCAYTTGGRDINLDILRVEGYRKFCNKIYQATKFALMRLGDDYQPPATEGLSGNE----SLVEKWILHKLTETSKIV 839
Cdd:PTZ00419  646 RFGLLAYTQQGRNINLDINRVVGYRHFCNKLWNAVKFALMKLLKDFNLPNSTLFKPNNveslPWEDKWILHRLNVAIKEV 725
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    840 NEALDKRDFLTSTSSIYEFW-YLICDVYIENSKYLIQEGSAIEKK-SAKDTLYILLDNALKLIHPFMPFISEEMWQRLPK 917
Cdd:PTZ00419  726 TEGFKEYDFSEATQATYNFWlYELCDVYLELIKPRLSKQSDGERKqHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLPN 805
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    918 RStEKAASIVKASYPVYVSEYDDVKSANAYDLVLNITKEARSLLSEYNILKNGK--VFVESNHEEYFKTAEDQKDSIVSL 995
Cdd:PTZ00419  806 YL-RKSESISIAKYPQPNPGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKpdCYVTAKDAELIELIESAENLISTL 884
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    996 IKaIDEVTVVRD---ASEIPEGCVLQSVNPEVNVHLLVKGHVDIDAEIAKVQKKLEKAKKSKNGIEQTINSKDYETKANT 1072
Cdd:PTZ00419  885 AK-IGSVSVIPPieeEAEVPKGCGFDVVDNKVIIYLNLDEFIDLKKELAKLEKKLAKLQKSLESYLKKISIPNYEDKVPE 963
                         970       980       990
                  ....*....|....*....|....*....|..
gi 6321531   1073 QAKEANKSKLDNTVAEIEGLEATIENLKRLKL 1104
Cdd:PTZ00419  964 DVRKLNDEKIDELNEEIKQLEQAIEELKSLLK 995
 
Name Accession Description Interval E-value
PTZ00419 PTZ00419
valyl-tRNA synthetase-like protein; Provisional
128-1104 0e+00

valyl-tRNA synthetase-like protein; Provisional


Pssm-ID: 240411 [Multi-domain]  Cd Length: 995  Bit Score: 1327.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    128 KTVPGEKKILVSlddPALKAYNPANVESSWYDWWIKTGVFEPeFTADGKVKPEGVFCIPAPPPNVTGALHIGHALTIAIQ 207
Cdd:PTZ00419   11 KDEKKNKKRNIS---SMAASYDPKEVESGWYEWWEKSGFFKP-AEDAKSLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQ 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    208 DSLIRYNRMKGKTVLFLPGFDHAGIATQSVVEKQIWAKDRKTRHDYGREAFVGKVWEWKEEYHSRIKNQIQKLGASYDWS 287
Cdd:PTZ00419   87 DSLIRYHRMKGDETLWVPGTDHAGIATQVVVEKKLMKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWS 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    288 REAFTLSPELTKSVEEAFVRLHDEGVIYRASRLVNWSVKLNTAISNLEVENKDVKSRTLLSVPGYDEKVEFGVLTSFAYP 367
Cdd:PTZ00419  167 REVFTMDEQRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEKPTKITIPGYDKKVEVGVLWHFAYP 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    368 VIGSDE-KLIIATTRPETIFGDTAVAVHPDDDRYKHLHGKFIQHPFLP-RKIPIITDKEAVDMEFGTGAVKITPAHDQND 445
Cdd:PTZ00419  247 LEDSGQeEIVVATTRIETMLGDVAVAVHPKDERYKKLHGKELIHPFIPdRKIPIIADDELVDMEFGTGAVKITPAHDPND 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    446 YNTGKRHNLEFINILTDDGLLNEECGPeWQGMKRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDIIEPLLKPQWW 525
Cdd:PTZ00419  327 YEIAKRHNLPFINIFTLDGKINENGGE-FAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWY 405
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    526 VSQSEMAKDAIKVVRDGQITITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVYFINIEGEEHDRIDGDYWVAGRSMEE 605
Cdd:PTZ00419  406 VNCKDMAKRAVEAVRNGELKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYRVISKGPETDPSDEEPWVVARSEEE 485
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    606 AEKKAAAKYPNSK--FTLEQDEDVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFSMLETGWDILFFWVTRMILLGLKLTG 683
Cdd:PTZ00419  486 ALEKAKKKFGLSEedFELEQDEDVLDTWFSSGLFPFSTLGWPDQTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTD 565
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    684 SVPFKEVFCHSLVRDAQGRKMSKSLGNVIDPLDVITGIKLDDLHAKLLQGNLDPREVEKAKIGQKESYPNGIPQCGTDAM 763
Cdd:PTZ00419  566 KLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGISLQDLNQKLYEGNLPEKEIKRAIELQKKEFPNGIPECGTDAL 645
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    764 RFALCAYTTGGRDINLDILRVEGYRKFCNKIYQATKFALMRLGDDYQPPATEGLSGNE----SLVEKWILHKLTETSKIV 839
Cdd:PTZ00419  646 RFGLLAYTQQGRNINLDINRVVGYRHFCNKLWNAVKFALMKLLKDFNLPNSTLFKPNNveslPWEDKWILHRLNVAIKEV 725
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    840 NEALDKRDFLTSTSSIYEFW-YLICDVYIENSKYLIQEGSAIEKK-SAKDTLYILLDNALKLIHPFMPFISEEMWQRLPK 917
Cdd:PTZ00419  726 TEGFKEYDFSEATQATYNFWlYELCDVYLELIKPRLSKQSDGERKqHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLPN 805
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    918 RStEKAASIVKASYPVYVSEYDDVKSANAYDLVLNITKEARSLLSEYNILKNGK--VFVESNHEEYFKTAEDQKDSIVSL 995
Cdd:PTZ00419  806 YL-RKSESISIAKYPQPNPGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKpdCYVTAKDAELIELIESAENLISTL 884
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    996 IKaIDEVTVVRD---ASEIPEGCVLQSVNPEVNVHLLVKGHVDIDAEIAKVQKKLEKAKKSKNGIEQTINSKDYETKANT 1072
Cdd:PTZ00419  885 AK-IGSVSVIPPieeEAEVPKGCGFDVVDNKVIIYLNLDEFIDLKKELAKLEKKLAKLQKSLESYLKKISIPNYEDKVPE 963
                         970       980       990
                  ....*....|....*....|....*....|..
gi 6321531   1073 QAKEANKSKLDNTVAEIEGLEATIENLKRLKL 1104
Cdd:PTZ00419  964 DVRKLNDEKIDELNEEIKQLEQAIEELKSLLK 995
valS TIGR00422
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ...
144-1083 0e+00

valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273070 [Multi-domain]  Cd Length: 861  Bit Score: 1238.40  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     144 ALKAYNPANVESSWYDWWIKTGVFEPEFTADGKVkpegvFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLF 223
Cdd:TIGR00422    1 MPKDYDPHEVEKKWYKKWEKSGFFKPDGNSNKPP-----FCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLW 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     224 LPGFDHAGIATQSVVEKQIWAKdRKTRHDYGREAFVGKVWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEE 303
Cdd:TIGR00422   76 LPGTDHAGIATQVKVEKKLGAE-GKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKE 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     304 AFVRLHDEGVIYRASRLVNWSVKLNTAISNLEVENKDVKSrtllSVPGYDEKVEFGvltsfaypvigSDEKLIIATTRPE 383
Cdd:TIGR00422  155 AFVRLYEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKG----KLYYIRYPLANG-----------SKDYLVVATTRPE 219
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     384 TIFGDTAVAVHPDDDRYKHLHGKFIQHPFLPRKIPIITDkEAVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFINILTDD 463
Cdd:TIGR00422  220 TMFGDTAVAVHPEDERYKHLIGKKVILPLTGRKIPIIAD-EYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDED 298
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     464 GLLNEECGpEWQGMKRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDIIEPLLKPQWWVSQSEMAKDAIKVVRDGQ 543
Cdd:TIGR00422  299 GLLNENAG-KYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAAEEGE 377
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     544 ITITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVYFINIEGEehdridgdYWVAGRSMEEAEKKAaakyPNSKFTLEQ 623
Cdd:TIGR00422  378 IKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVWYCKECGE--------VYVAKEEPLPDDKTN----TGPSVELEQ 445
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     624 DEDVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFSMLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQGRK 703
Cdd:TIGR00422  446 DTDVLDTWFSSSLWPFSTLGWPDETKDLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRK 525
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     704 MSKSLGNVIDPLDVITgiklddlhakllqgnldprevekakigqkesypngipQCGTDAMRFALCAYTTGGRDINLDILR 783
Cdd:TIGR00422  526 MSKSLGNVIDPLDVIE-------------------------------------KYGADALRFTLASLVTPGDDINFDWKR 568
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     784 VEGYRKFCNKIYQATKFALMRLGDDyqpPATEGLSGNESLVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYEF-WYLI 862
Cdd:TIGR00422  569 VESARNFLNKLWNASRFVLMNLSDD---LELSGGEEKLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFiWNDF 645
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     863 CDVYIENSKYLIQEGSAIEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQRLPkrstEKAASIVKASYPVYVSEYDDVK 942
Cdd:TIGR00422  646 CDWYIELVKYRLYNGNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFK----EGADSIMLQSYPVVDAEFVDEE 721
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     943 SANAYDLVLNITKEARSLLSEYNILKNGKVFVESNHEEYfKTAEDQKDSIVSLIKAID--EVTVVRDASEIPegCVLQSV 1020
Cdd:TIGR00422  722 AEKAFELLKEIIVSIRNLKAESNIPPNAPLKVLLIYTEA-ETAERLKLNAVDIKGAINfsEVEVVIEKPEVT--EAVVEL 798
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6321531    1021 NPEVNVHLLVKGHVDIDAEIAKVQKKLEKAKKSKNGIEQTINSKDYETKANTQAKEANKSKLD 1083
Cdd:TIGR00422  799 VPGFEIIIPVKGLINKAKELARLQKQLDKEKKEVIRIEGKLENEGFVKKAPKEVIEKEKEKLE 861
ValS COG0525
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ...
146-1100 0e+00

Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440291 [Multi-domain]  Cd Length: 877  Bit Score: 1160.19  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   146 KAYNPANVESSWYDWWIKTGVFEPEftADGKVKPegvFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLP 225
Cdd:COG0525    5 KTYDPKEVEAKWYQYWEENGYFKAD--PDSDKEP---FTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWQP 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   226 GFDHAGIATQSVVEKQIwAKDRKTRHDYGREAFVGKVWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAF 305
Cdd:COG0525   80 GTDHAGIATQAVVERQL-AEEGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVF 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   306 VRLHDEGVIYRASRLVNWSVKLNTAISNLEVENKDVKsrtllsvpgydekvefGVLTSFAYPVIGSDEKLIIATTRPETI 385
Cdd:COG0525  159 VRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVK----------------GHLWHIRYPLADGSGYIVVATTRPETM 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   386 FGDTAVAVHPDDDRYKHLHGKFIQHPFLPRKIPIITDkEAVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFINILTDDGL 465
Cdd:COG0525  223 LGDTAVAVHPEDERYKHLIGKTVILPLVGREIPIIAD-EYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDEDGT 301
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   466 LNEECGpEWQGMKRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDIIEPLLKPQWWVSQSEMAKDAIKVVRDGQIT 545
Cdd:COG0525  302 INENAG-KYRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEAVEDGEIK 380
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   546 ITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVYFINiegeehdriDGDYWVAgRSMEEAEKKAAAKypnskfTLEQDE 625
Cdd:COG0525  381 FVPERWEKTYFHWMENIRDWCISRQLWWGHRIPAWYCP---------DGEVYVA-RTEPEACAKAGSV------NLTQDE 444
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   626 DVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFSMLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQGRKMS 705
Cdd:COG0525  445 DVLDTWFSSALWPFSTLGWPEKTEDLKYFYPTSVLVTGFDIIFFWVARMIMMGLHFTGEVPFKDVYIHGLVRDEQGRKMS 524
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   706 KSLGNVIDPLDVItgiklddlhakllqgnldprevekakigqkESYpngipqcGTDAMRFALCAYTTGGRDINLDILRVE 785
Cdd:COG0525  525 KSKGNVIDPLDLI------------------------------DKY-------GADALRFTLAALASPGRDIKFDEERVE 567
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   786 GYRKFCNKIYQATKFALMRLGDdyQPPATEGLSGNESLVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYEF-WYLICD 864
Cdd:COG0525  568 GYRNFANKLWNASRFVLMNLEG--FDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFvWNEFCD 645
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   865 VYIENSKYLIQEGSAIEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQRLPKRSTEKaaSIVKASYPVYVSEYDDVKSA 944
Cdd:COG0525  646 WYLELAKPRLYGGDEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKLPPRKEGE--SIMLAPWPEADEELIDEEAE 723
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   945 NAYDLVLNITKEARSLLSEYNIlKNGK---VFVESNHEEYFKTAEDQKDSIVSLIKaIDEVTVVrdASEIPEGCVlQSVN 1021
Cdd:COG0525  724 AEFEWLKEVISAIRNIRAEMNI-PPSKklpLLLKGADEADRARLEENAAYIKRLAR-LEEITIL--VDEKPEGAA-SAVV 798
                        890       900       910       920       930       940       950
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6321531  1022 PEVNVHLLVKGHVDIDAEIAKVQKKLEKAKKSKNGIEQTINSKDYETKANTQAKEANKSKLDNTVAEIEGLEATIENLK 1100
Cdd:COG0525  799 GGAEVFLPLEGLIDVEAERARLEKELAKLEKEIARVEKKLSNEGFVAKAPAEVVEKEREKLAEAEAKLEKLEEQLARLK 877
tRNA-synt_1 pfam00133
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ...
156-780 0e+00

tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.


Pssm-ID: 459685 [Multi-domain]  Cd Length: 602  Bit Score: 837.06  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     156 SWYDWWIKTGVFEPEFTADgKVKPEgvFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIATQ 235
Cdd:pfam00133    1 QIYEFWDEQGYFKPELEKR-KGKPS--FTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTE 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     236 SVVEKQIWAKDRKTRHDYGREAFVGKVWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGVIY 315
Cdd:pfam00133   78 QVVEKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIY 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     316 RASRLVNWSVKLNTAISNLEVENKDVKsrtllsvpgydekvefGVLTSFAYPVIGSDE-KLIIATTRPETIFGDTAVAVH 394
Cdd:pfam00133  158 RGKKLVNWSPALNTALSNLEVEYKDVK----------------GPSIHVAFPLADDEGaSLVIWTTTPWTLPGNTAVAVN 221
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     395 PD-------------------------------DDRYKHLHGKFIQHPFLPRKIPIITDkEAVDMEFGTGAVKITPAHDQ 443
Cdd:pfam00133  222 PEfdyvitgegyilaeallkslykkgtdkkileDFRGKELEGKEAIHPFVNREIPIITD-DYVDMEFGTGAVHIAPAHGE 300
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     444 NDYNTGKRHNLEFINILTDDGLLNEECgPEWQGMKRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDIIEPLLKPQ 523
Cdd:pfam00133  301 NDYEVGQRHNLEVINPVDDDGTFTEEA-PDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQ 379
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     524 WWVSQSEMAKDAIKVVRdgQITITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVYFINIEGEEHDRIDGDYWVAGRSM 603
Cdd:pfam00133  380 WFVRMDELADQALEAVE--KVQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGELFELVAGRFE 457
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     604 EEAEKKAAAKYPNSKF-----TLEQDEDVLDTWFSSGLWPFSTLGWPEK-TKDMETFYPFSMLETGWDILFFWVTRMILL 677
Cdd:pfam00133  458 EEGSIKWLHREAKDKLgygkgTLEQDEDVLDTWFSSGSWPFSTLGWPFVnTEEFKKFFPADMLLEGSDQTRGWFYRMIML 537
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     678 GLKLTGSVPFKEVFCHSLVRDAQGRKMSKSLGNVIDPLDVITgiklddlhakllqgnldprevekakigqkesypngipQ 757
Cdd:pfam00133  538 STALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVID-------------------------------------K 580
                          650       660
                   ....*....|....*....|...
gi 6321531     758 CGTDAMRFALCaYTTGGRDINLD 780
Cdd:pfam00133  581 YGADALRLWLA-NSDYGRDINLS 602
ValRS_core cd00817
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ...
181-779 0e+00

catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 185677 [Multi-domain]  Cd Length: 382  Bit Score: 589.22  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   181 GVFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIATQSVVEKQIWAKdRKTRHDYGREAFVG 260
Cdd:cd00817    1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIE-GKTRHDLGREEFLE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   261 KVWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGVIYRASRLVNWSVKLNTAISNLEVenkd 340
Cdd:cd00817   80 KCWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV---- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   341 vksrtllsvpgydekvefgvltsfaypvigsdekliiattrpetifgdtavavhpdddrykhlhgkfiqhpflprkipii 420
Cdd:cd00817      --------------------------------------------------------------------------------
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   421 tdkeavdmefgtgavkitpahdqndyntgkrhnlefiniltddgllneecgpewqgmkrfdarkkvieqlkeknlyvgqe 500
Cdd:cd00817      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   501 dnemtiptCSRSGDIIEPLLKPQWWVSQSEMAKDAIKVVRDGQITITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVY 580
Cdd:cd00817  156 --------CSRSGDVIEPLLKPQWFVKVKDLAKKALEAVKEGDIKFVPERMEKRYENWLENIRDWCISRQLWWGHRIPAW 227
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   581 FINiegeehdriDGDYWVAGRSME--EAEKKAAAKYPNSKFTLEQDEDVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFS 658
Cdd:cd00817  228 YCK---------DGGHWVVAREEDeaIDKAAPEACVPCGGEELKQDEDVLDTWFSSSLWPFSTLGWPEETKDLKKFYPTS 298
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   659 MLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQGRKMSKSLGNVIDPLDVITGIklddlhakllqgnldpr 738
Cdd:cd00817  299 LLVTGHDIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGY----------------- 361
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|.
gi 6321531   739 evekakigqkesypngipqcGTDAMRFALCAYTTGGRDINL 779
Cdd:cd00817  362 --------------------GADALRFTLASAATQGRDINL 382
 
Name Accession Description Interval E-value
PTZ00419 PTZ00419
valyl-tRNA synthetase-like protein; Provisional
128-1104 0e+00

valyl-tRNA synthetase-like protein; Provisional


Pssm-ID: 240411 [Multi-domain]  Cd Length: 995  Bit Score: 1327.71  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    128 KTVPGEKKILVSlddPALKAYNPANVESSWYDWWIKTGVFEPeFTADGKVKPEGVFCIPAPPPNVTGALHIGHALTIAIQ 207
Cdd:PTZ00419   11 KDEKKNKKRNIS---SMAASYDPKEVESGWYEWWEKSGFFKP-AEDAKSLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQ 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    208 DSLIRYNRMKGKTVLFLPGFDHAGIATQSVVEKQIWAKDRKTRHDYGREAFVGKVWEWKEEYHSRIKNQIQKLGASYDWS 287
Cdd:PTZ00419   87 DSLIRYHRMKGDETLWVPGTDHAGIATQVVVEKKLMKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWS 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    288 REAFTLSPELTKSVEEAFVRLHDEGVIYRASRLVNWSVKLNTAISNLEVENKDVKSRTLLSVPGYDEKVEFGVLTSFAYP 367
Cdd:PTZ00419  167 REVFTMDEQRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEKPTKITIPGYDKKVEVGVLWHFAYP 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    368 VIGSDE-KLIIATTRPETIFGDTAVAVHPDDDRYKHLHGKFIQHPFLP-RKIPIITDKEAVDMEFGTGAVKITPAHDQND 445
Cdd:PTZ00419  247 LEDSGQeEIVVATTRIETMLGDVAVAVHPKDERYKKLHGKELIHPFIPdRKIPIIADDELVDMEFGTGAVKITPAHDPND 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    446 YNTGKRHNLEFINILTDDGLLNEECGPeWQGMKRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDIIEPLLKPQWW 525
Cdd:PTZ00419  327 YEIAKRHNLPFINIFTLDGKINENGGE-FAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWY 405
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    526 VSQSEMAKDAIKVVRDGQITITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVYFINIEGEEHDRIDGDYWVAGRSMEE 605
Cdd:PTZ00419  406 VNCKDMAKRAVEAVRNGELKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYRVISKGPETDPSDEEPWVVARSEEE 485
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    606 AEKKAAAKYPNSK--FTLEQDEDVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFSMLETGWDILFFWVTRMILLGLKLTG 683
Cdd:PTZ00419  486 ALEKAKKKFGLSEedFELEQDEDVLDTWFSSGLFPFSTLGWPDQTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTD 565
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    684 SVPFKEVFCHSLVRDAQGRKMSKSLGNVIDPLDVITGIKLDDLHAKLLQGNLDPREVEKAKIGQKESYPNGIPQCGTDAM 763
Cdd:PTZ00419  566 KLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGISLQDLNQKLYEGNLPEKEIKRAIELQKKEFPNGIPECGTDAL 645
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    764 RFALCAYTTGGRDINLDILRVEGYRKFCNKIYQATKFALMRLGDDYQPPATEGLSGNE----SLVEKWILHKLTETSKIV 839
Cdd:PTZ00419  646 RFGLLAYTQQGRNINLDINRVVGYRHFCNKLWNAVKFALMKLLKDFNLPNSTLFKPNNveslPWEDKWILHRLNVAIKEV 725
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    840 NEALDKRDFLTSTSSIYEFW-YLICDVYIENSKYLIQEGSAIEKK-SAKDTLYILLDNALKLIHPFMPFISEEMWQRLPK 917
Cdd:PTZ00419  726 TEGFKEYDFSEATQATYNFWlYELCDVYLELIKPRLSKQSDGERKqHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLPN 805
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    918 RStEKAASIVKASYPVYVSEYDDVKSANAYDLVLNITKEARSLLSEYNILKNGK--VFVESNHEEYFKTAEDQKDSIVSL 995
Cdd:PTZ00419  806 YL-RKSESISIAKYPQPNPGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKpdCYVTAKDAELIELIESAENLISTL 884
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    996 IKaIDEVTVVRD---ASEIPEGCVLQSVNPEVNVHLLVKGHVDIDAEIAKVQKKLEKAKKSKNGIEQTINSKDYETKANT 1072
Cdd:PTZ00419  885 AK-IGSVSVIPPieeEAEVPKGCGFDVVDNKVIIYLNLDEFIDLKKELAKLEKKLAKLQKSLESYLKKISIPNYEDKVPE 963
                         970       980       990
                  ....*....|....*....|....*....|..
gi 6321531   1073 QAKEANKSKLDNTVAEIEGLEATIENLKRLKL 1104
Cdd:PTZ00419  964 DVRKLNDEKIDELNEEIKQLEQAIEELKSLLK 995
valS TIGR00422
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ...
144-1083 0e+00

valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273070 [Multi-domain]  Cd Length: 861  Bit Score: 1238.40  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     144 ALKAYNPANVESSWYDWWIKTGVFEPEFTADGKVkpegvFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLF 223
Cdd:TIGR00422    1 MPKDYDPHEVEKKWYKKWEKSGFFKPDGNSNKPP-----FCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLW 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     224 LPGFDHAGIATQSVVEKQIWAKdRKTRHDYGREAFVGKVWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEE 303
Cdd:TIGR00422   76 LPGTDHAGIATQVKVEKKLGAE-GKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKE 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     304 AFVRLHDEGVIYRASRLVNWSVKLNTAISNLEVENKDVKSrtllSVPGYDEKVEFGvltsfaypvigSDEKLIIATTRPE 383
Cdd:TIGR00422  155 AFVRLYEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKG----KLYYIRYPLANG-----------SKDYLVVATTRPE 219
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     384 TIFGDTAVAVHPDDDRYKHLHGKFIQHPFLPRKIPIITDkEAVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFINILTDD 463
Cdd:TIGR00422  220 TMFGDTAVAVHPEDERYKHLIGKKVILPLTGRKIPIIAD-EYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDED 298
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     464 GLLNEECGpEWQGMKRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDIIEPLLKPQWWVSQSEMAKDAIKVVRDGQ 543
Cdd:TIGR00422  299 GLLNENAG-KYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAAEEGE 377
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     544 ITITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVYFINIEGEehdridgdYWVAGRSMEEAEKKAaakyPNSKFTLEQ 623
Cdd:TIGR00422  378 IKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVWYCKECGE--------VYVAKEEPLPDDKTN----TGPSVELEQ 445
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     624 DEDVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFSMLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQGRK 703
Cdd:TIGR00422  446 DTDVLDTWFSSSLWPFSTLGWPDETKDLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRK 525
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     704 MSKSLGNVIDPLDVITgiklddlhakllqgnldprevekakigqkesypngipQCGTDAMRFALCAYTTGGRDINLDILR 783
Cdd:TIGR00422  526 MSKSLGNVIDPLDVIE-------------------------------------KYGADALRFTLASLVTPGDDINFDWKR 568
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     784 VEGYRKFCNKIYQATKFALMRLGDDyqpPATEGLSGNESLVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYEF-WYLI 862
Cdd:TIGR00422  569 VESARNFLNKLWNASRFVLMNLSDD---LELSGGEEKLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFiWNDF 645
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     863 CDVYIENSKYLIQEGSAIEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQRLPkrstEKAASIVKASYPVYVSEYDDVK 942
Cdd:TIGR00422  646 CDWYIELVKYRLYNGNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFK----EGADSIMLQSYPVVDAEFVDEE 721
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     943 SANAYDLVLNITKEARSLLSEYNILKNGKVFVESNHEEYfKTAEDQKDSIVSLIKAID--EVTVVRDASEIPegCVLQSV 1020
Cdd:TIGR00422  722 AEKAFELLKEIIVSIRNLKAESNIPPNAPLKVLLIYTEA-ETAERLKLNAVDIKGAINfsEVEVVIEKPEVT--EAVVEL 798
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6321531    1021 NPEVNVHLLVKGHVDIDAEIAKVQKKLEKAKKSKNGIEQTINSKDYETKANTQAKEANKSKLD 1083
Cdd:TIGR00422  799 VPGFEIIIPVKGLINKAKELARLQKQLDKEKKEVIRIEGKLENEGFVKKAPKEVIEKEKEKLE 861
ValS COG0525
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ...
146-1100 0e+00

Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440291 [Multi-domain]  Cd Length: 877  Bit Score: 1160.19  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   146 KAYNPANVESSWYDWWIKTGVFEPEftADGKVKPegvFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLP 225
Cdd:COG0525    5 KTYDPKEVEAKWYQYWEENGYFKAD--PDSDKEP---FTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWQP 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   226 GFDHAGIATQSVVEKQIwAKDRKTRHDYGREAFVGKVWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAF 305
Cdd:COG0525   80 GTDHAGIATQAVVERQL-AEEGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVF 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   306 VRLHDEGVIYRASRLVNWSVKLNTAISNLEVENKDVKsrtllsvpgydekvefGVLTSFAYPVIGSDEKLIIATTRPETI 385
Cdd:COG0525  159 VRLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVK----------------GHLWHIRYPLADGSGYIVVATTRPETM 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   386 FGDTAVAVHPDDDRYKHLHGKFIQHPFLPRKIPIITDkEAVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFINILTDDGL 465
Cdd:COG0525  223 LGDTAVAVHPEDERYKHLIGKTVILPLVGREIPIIAD-EYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDEDGT 301
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   466 LNEECGpEWQGMKRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDIIEPLLKPQWWVSQSEMAKDAIKVVRDGQIT 545
Cdd:COG0525  302 INENAG-KYRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEAVEDGEIK 380
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   546 ITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVYFINiegeehdriDGDYWVAgRSMEEAEKKAAAKypnskfTLEQDE 625
Cdd:COG0525  381 FVPERWEKTYFHWMENIRDWCISRQLWWGHRIPAWYCP---------DGEVYVA-RTEPEACAKAGSV------NLTQDE 444
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   626 DVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFSMLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQGRKMS 705
Cdd:COG0525  445 DVLDTWFSSALWPFSTLGWPEKTEDLKYFYPTSVLVTGFDIIFFWVARMIMMGLHFTGEVPFKDVYIHGLVRDEQGRKMS 524
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   706 KSLGNVIDPLDVItgiklddlhakllqgnldprevekakigqkESYpngipqcGTDAMRFALCAYTTGGRDINLDILRVE 785
Cdd:COG0525  525 KSKGNVIDPLDLI------------------------------DKY-------GADALRFTLAALASPGRDIKFDEERVE 567
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   786 GYRKFCNKIYQATKFALMRLGDdyQPPATEGLSGNESLVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYEF-WYLICD 864
Cdd:COG0525  568 GYRNFANKLWNASRFVLMNLEG--FDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFvWNEFCD 645
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   865 VYIENSKYLIQEGSAIEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQRLPKRSTEKaaSIVKASYPVYVSEYDDVKSA 944
Cdd:COG0525  646 WYLELAKPRLYGGDEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKLPPRKEGE--SIMLAPWPEADEELIDEEAE 723
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   945 NAYDLVLNITKEARSLLSEYNIlKNGK---VFVESNHEEYFKTAEDQKDSIVSLIKaIDEVTVVrdASEIPEGCVlQSVN 1021
Cdd:COG0525  724 AEFEWLKEVISAIRNIRAEMNI-PPSKklpLLLKGADEADRARLEENAAYIKRLAR-LEEITIL--VDEKPEGAA-SAVV 798
                        890       900       910       920       930       940       950
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6321531  1022 PEVNVHLLVKGHVDIDAEIAKVQKKLEKAKKSKNGIEQTINSKDYETKANTQAKEANKSKLDNTVAEIEGLEATIENLK 1100
Cdd:COG0525  799 GGAEVFLPLEGLIDVEAERARLEKELAKLEKEIARVEKKLSNEGFVAKAPAEVVEKEREKLAEAEAKLEKLEEQLARLK 877
valS PRK05729
valyl-tRNA synthetase; Reviewed
146-1101 0e+00

valyl-tRNA synthetase; Reviewed


Pssm-ID: 235582 [Multi-domain]  Cd Length: 874  Bit Score: 1130.97  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    146 KAYNPANVESSWYDWWIKTGVFEPEftaDGKVKPegvFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLP 225
Cdd:PRK05729    7 KTYDPKEVEAKWYQKWEEKGYFKPD---DNSKKP---FSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWLP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    226 GFDHAGIATQSVVEKQIwAKDRKTRHDYGREAFVGKVWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAF 305
Cdd:PRK05729   81 GTDHAGIATQMVVERQL-AAEGKSRHDLGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVF 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    306 VRLHDEGVIYRASRLVNWSVKLNTAISNLEVENKDVKsrtllsvpgydekvefGVLTSFAYPVIGSDEKLIIATTRPETI 385
Cdd:PRK05729  160 VRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVK----------------GKLWHIRYPLADGSDYLVVATTRPETM 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    386 FGDTAVAVHPDDDRYKHLHGKFIQHPFLPRKIPIITDkEAVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFINILTDDGL 465
Cdd:PRK05729  224 LGDTAVAVNPEDERYKHLIGKTVILPLVGREIPIIAD-EYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDEDGT 302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    466 LNEECGpEWQGMKRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDIIEPLLKPQWWVSQSEMAKDAIKVVRDGQIT 545
Cdd:PRK05729  303 INENPG-EYQGLDRFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAVENGEIK 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    546 ITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVYFINiegeehdriDGDYWVAgrsmeeaekkAAAKYPNSKFTLEQDE 625
Cdd:PRK05729  382 FVPERWEKTYFHWMENIQDWCISRQLWWGHRIPAWYDE---------DGEVYVG----------REEPEAREKALLTQDE 442
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    626 DVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFSMLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQGRKMS 705
Cdd:PRK05729  443 DVLDTWFSSALWPFSTLGWPEKTEDLKRFYPTSVLVTGFDIIFFWVARMIMMGLHFTGQVPFKDVYIHGLVRDEQGRKMS 522
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    706 KSLGNVIDPLDVItgiklddlhakllqgnldprevekakigqkESYpngipqcGTDAMRFALCAYTTGGRDINLDILRVE 785
Cdd:PRK05729  523 KSKGNVIDPLDLI------------------------------DKY-------GADALRFTLAALASPGRDIRFDEERVE 565
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    786 GYRKFCNKIYQATKFALMRLGDDyqPPATEGLSGNESLVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYEF-WYLICD 864
Cdd:PRK05729  566 GYRNFANKLWNASRFVLMNLEGA--DVGELPDPEELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFiWNEFCD 643
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    865 VYIENSKYLIQEGsaiEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQRLPKRSTEKaaSIVKASYPVYVSEYDDvKSA 944
Cdd:PRK05729  644 WYLELAKPVLQEA---AKRATRATLAYVLEQILRLLHPFMPFITEELWQKLAPLGIEE--SIMLAPWPEADEAIDE-AAE 717
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    945 NAYDLVLNITKEARSLLSEYNIlKNGK---VFVESNHEEYFKTAEDQKDSIVSLIKaIDEVTVVRDASEIPEGCVlQSVN 1021
Cdd:PRK05729  718 AEFEWLKELITAIRNIRAEMNI-PPSKklpLLLKGADAEDRARLEANEAYIKRLAR-LESLEILADDEEAPEGAA-SAVV 794
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   1022 PEVNVHLLVKGHVDIDAEIAKVQKKLEKAKKSKNGIEQTINSKDYETKANTQAKEANKSKLDNTVAEIEGLEATIENLKR 1101
Cdd:PRK05729  795 GGAELFLPLEGLIDVEAELARLEKELAKLEKEIERVEKKLSNEGFVAKAPEEVVEKEREKLAEYEEKLAKLKERLARLKA 874
PLN02381 PLN02381
valyl-tRNA synthetase
118-1099 0e+00

valyl-tRNA synthetase


Pssm-ID: 215214 [Multi-domain]  Cd Length: 1066  Bit Score: 1079.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    118 EVEPIPEFIDKTVP-GEKKILVSLddpALKAYNPANVESSWYDWWIKTGVFepefTADGK-VKPEgvFCIPAPPPNVTGA 195
Cdd:PLN02381   72 EDENPEDFIDPDTPfGQKKRLSSQ---MAKQYSPSAVEKSWYAWWEKSGYF----GADAKsSKPP--FVIVLPPPNVTGA 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    196 LHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIATQSVVEKQIWAKDRKTRHDYGREAFVGKVWEWKEEYHSRIKN 275
Cdd:PLN02381  143 LHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIATQVVVEKKLMRERHLTRHDIGREEFVSEVWKWKDEYGGTILN 222
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    276 QIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGVIYRASRLVNWSVKLNTAISNLEVENKDVKSRTLLSVPGYDEK 355
Cdd:PLN02381  223 QLRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEVDYIDIKERTLLKVPGYDKP 302
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    356 VEFGVLTSFAYPVIGSDEKLIIATTRPETIFGDTAVAVHPDDDRYKHLHGKFIQHPFLPRKIPIITDKEAVDMEFGTGAV 435
Cdd:PLN02381  303 VEFGVLTSFAYPLEGGLGEIVVATTRIETMLGDTAIAIHPDDERYKHLHGKFAVHPFNGRKLPIICDAILVDPNFGTGAV 382
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    436 KITPAHDQNDYNTGKRHNLEFINILTDDGLLNEECGPEWQGMKRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDI 515
Cdd:PLN02381  383 KITPAHDPNDFEVGKRHNLEFINIFTDDGKINSNGGSEFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNDV 462
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    516 IEPLLKPQWWVSQSEMAKDAIKVVRDGQ---ITITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVYFINIEGEEHDRI 592
Cdd:PLN02381  463 VEPMIKPQWFVNCSSMAKQALDAAIDGEnkkLEFIPKQYLAEWKRWLENIRDWCISRQLWWGHRIPAWYVTLEDDQLKEL 542
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    593 D--GDYWVAGRSMEEAEKKAAAKYPNSKFTLEQDEDVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFSMLETGWDILFFW 670
Cdd:PLN02381  543 GsyNDHWVVARNESDALLEASQKFPGKKFELSQDPDVLDTWFSSGLFPLSVLGWPDDTDDLKAFYPTSVLETGHDILFFW 622
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    671 VTRMILLGLKLTGSVPFKEVFCHSLVRDAQGRKMSKSLGNVIDPLDVITGIKLDDLHAKLLQGNLDPREVEKAKIGQKES 750
Cdd:PLN02381  623 VARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINGISLEGLHKRLEEGNLDPKELVVAKEGQKKD 702
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    751 YPNGIPQCGTDAMRFALCAYTTGGRDINLDILRVEGYRKFCNKIYQATKFALMRLGDDYQPPATEGLSGNESLVeKWILH 830
Cdd:PLN02381  703 FPNGIAECGTDALRFALVSYTAQSDKINLDILRVVGYRQWCNKLWNAVRFAMSKLGDDYTPPATLSVETMPFSC-KWILS 781
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    831 KLTET-SKIVNeALDKRDFLTSTSSIYEFW-YLICDVYIENSK-YLIQEGS--AIEKKSAKDTLYILLDNALKLIHPFMP 905
Cdd:PLN02381  782 VLNKAiSKTVS-SLDAYEFSDAASTVYSWWqYQFCDVFIEAIKpYFAGDNPefASERAAAQDTLWICLDTGLRLLHPFMP 860
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    906 FISEEMWQRLPK-RSTEKAASIVKASYPVYVSEYDDVKSANAYDLVLNITKEARSLLSE-YNILKNGKV--FVESNHEEY 981
Cdd:PLN02381  861 FVTEELWQRLPQpKDHTRKDSIMISEYPSAVEAWTNEKVEYEMDLVLSTVKCLRSLRAEvLEKQKNERLpaFALCRNQEI 940
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    982 FKTAEDQKDSIVSLIKAIDEVTVVRDASEIPEGCVLQSVNPEVNVHLLVKGHVDIDAEIAKVQKKLEKAKKSKNGIEQTI 1061
Cdd:PLN02381  941 AAIIKSHQLEILTLANLSSLKVLLSENDAPPAGCAFENVNENLKVYLQAQGAVNAEAELEKLRNKMDEIQKQQEKLEKKM 1020
                         970       980       990
                  ....*....|....*....|....*....|....*...
gi 6321531   1062 NSKDYETKANTQAKEANKSKLDNTVAEIEGLEATIENL 1099
Cdd:PLN02381 1021 NASGYKEKVPANIQEEDARKLTKLLQELEFFEKESKRL 1058
valS PRK14900
valyl-tRNA synthetase; Provisional
146-1094 0e+00

valyl-tRNA synthetase; Provisional


Pssm-ID: 237855 [Multi-domain]  Cd Length: 1052  Bit Score: 838.49  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    146 KAYNPANVESSWYDWWIKTGVFEPEfTADGKVKPegvFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLP 225
Cdd:PRK14900   17 KGYEHREVEARWYPFWQERGYFHGD-EHDRTRPP---FSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLP 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    226 GFDHAGIATQSVVEKQIWAKDRKTRHDYGREAFVGKVWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAF 305
Cdd:PRK14900   93 GTDHAGIATQMIVEKELKKTEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVF 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    306 VRLHDEGVIYRASRLVNWSVKLNTAISNLEVENKDVKSrtllsvpgydekvefGVLTSFAYPVIGSDEKLIIATTRPETI 385
Cdd:PRK14900  173 VRLHEEGLIYREKKLINWCPDCRTALSDLEVEHEEAHQ---------------GELWSFAYPLADGSGEIVVATTRPETM 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    386 FGDTAVAVHPDDDRYKHLHGKFIQHPFLPRKIPIITDKEAVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFINILTDDGL 465
Cdd:PRK14900  238 LGDTAVAVHPLDPRYMALHGKKVRHPITGRTFPIVADAILVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDGR 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    466 LNEECGPeWQGMKRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDIIEPLLKPQWWVSQSEMAKDAIKVVRDGQIT 545
Cdd:PRK14900  318 MTAEAGP-LAGLDRFEARKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVRIEPLARPAIEAVEQGRTR 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    546 ITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVYFINiegeehdriDGDYWVAGRSmeeaekkaaakyPNS-----KFT 620
Cdd:PRK14900  397 FIPEQWTNTYMAWMRNIHDWCISRQLWWGHQIPAWYCP---------DGHVTVARET------------PEAcstcgKAE 455
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    621 LEQDEDVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFSMLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQ 700
Cdd:PRK14900  456 LRQDEDVLDTWFSSGLWPFSTMGWPEQTDTLRTFYPTSVMETGHDIIFFWVARMMMMGLHFMGEVPFRTVYLHPMVRDEK 535
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    701 GRKMSKSLGNVIDPLDVitgiklddlhakllqgnldprevekakigqkesypngIPQCGTDAMRFALCAYTTGGRDINLD 780
Cdd:PRK14900  536 GQKMSKTKGNVIDPLVI-------------------------------------TEQYGADALRFTLAALTAQGRDIKLA 578
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    781 ILRVEGYRKFCNKIYQATKFALMRLGD---DYQPPATEGLsgneSLVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYE 857
Cdd:PRK14900  579 KERIEGYRAFANKLWNASRFALMNLSGyqeRGEDPARLAR----TPADRWILARLQRAVNETVEALEAFRFNDAANAVYA 654
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    858 F-WYLICDVYIENSKYLIQEGSAIEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQRLP--KRSTEKAASIVKASYPvY 934
Cdd:PRK14900  655 FvWHELCDWYIELAKEALASEDPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHVLRaqVGASAWADSVLAAEYP-R 733
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    935 VSEYDDVKSAnAYDLVLNITKEARSLLSEYNI------LKNGKVFVESNHEEYFKTAEDQKDSIVSLIKAIDEVTVVRDA 1008
Cdd:PRK14900  734 KGEADEAAEA-AFRPVLGIIDAVRNIRGEMGIpwkvklGAQAPVEIAVADPALRDLLQAGELARVHRVAGVEGSRLVVAA 812
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   1009 SEIPEGCVLQSVNPEVNVHLLVKGHVDIDAEIAKVQKKLEKAKKSKNGIEQTINSKDYETKANTQAKEAN---------- 1078
Cdd:PRK14900  813 ATAPAPQSAVGVGPGFEVRVPLAGVIDLAAETARVDKEIGKVDQDLAVLERKLQNPSFVQNAPPAVVEKDraraeelrek 892
                         970
                  ....*....|....*.
gi 6321531   1079 KSKLDNTVAEIEGLEA 1094
Cdd:PRK14900  893 RGKLEAHRAMLSGSEA 908
tRNA-synt_1 pfam00133
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ...
156-780 0e+00

tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.


Pssm-ID: 459685 [Multi-domain]  Cd Length: 602  Bit Score: 837.06  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     156 SWYDWWIKTGVFEPEFTADgKVKPEgvFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIATQ 235
Cdd:pfam00133    1 QIYEFWDEQGYFKPELEKR-KGKPS--FTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTE 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     236 SVVEKQIWAKDRKTRHDYGREAFVGKVWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGVIY 315
Cdd:pfam00133   78 QVVEKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIY 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     316 RASRLVNWSVKLNTAISNLEVENKDVKsrtllsvpgydekvefGVLTSFAYPVIGSDE-KLIIATTRPETIFGDTAVAVH 394
Cdd:pfam00133  158 RGKKLVNWSPALNTALSNLEVEYKDVK----------------GPSIHVAFPLADDEGaSLVIWTTTPWTLPGNTAVAVN 221
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     395 PD-------------------------------DDRYKHLHGKFIQHPFLPRKIPIITDkEAVDMEFGTGAVKITPAHDQ 443
Cdd:pfam00133  222 PEfdyvitgegyilaeallkslykkgtdkkileDFRGKELEGKEAIHPFVNREIPIITD-DYVDMEFGTGAVHIAPAHGE 300
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     444 NDYNTGKRHNLEFINILTDDGLLNEECgPEWQGMKRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDIIEPLLKPQ 523
Cdd:pfam00133  301 NDYEVGQRHNLEVINPVDDDGTFTEEA-PDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQ 379
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     524 WWVSQSEMAKDAIKVVRdgQITITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVYFINIEGEEHDRIDGDYWVAGRSM 603
Cdd:pfam00133  380 WFVRMDELADQALEAVE--KVQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGELFELVAGRFE 457
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     604 EEAEKKAAAKYPNSKF-----TLEQDEDVLDTWFSSGLWPFSTLGWPEK-TKDMETFYPFSMLETGWDILFFWVTRMILL 677
Cdd:pfam00133  458 EEGSIKWLHREAKDKLgygkgTLEQDEDVLDTWFSSGSWPFSTLGWPFVnTEEFKKFFPADMLLEGSDQTRGWFYRMIML 537
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     678 GLKLTGSVPFKEVFCHSLVRDAQGRKMSKSLGNVIDPLDVITgiklddlhakllqgnldprevekakigqkesypngipQ 757
Cdd:pfam00133  538 STALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVID-------------------------------------K 580
                          650       660
                   ....*....|....*....|...
gi 6321531     758 CGTDAMRFALCaYTTGGRDINLD 780
Cdd:pfam00133  581 YGADALRLWLA-NSDYGRDINLS 602
PLN02943 PLN02943
aminoacyl-tRNA ligase
154-1095 0e+00

aminoacyl-tRNA ligase


Pssm-ID: 215509 [Multi-domain]  Cd Length: 958  Bit Score: 720.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    154 ESSWYDWWIKTGVFEPEFTADGKvkPegvFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIA 233
Cdd:PLN02943   66 EERIYNWWESQGYFKPNFDRGGD--P---FVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIA 140
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    234 TQSVVEKQIWAKDRKtRHDYGREAFVGKVWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGV 313
Cdd:PLN02943  141 TQLVVEKMLASEGIK-RTDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGL 219
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    314 IYRASRLVNWSVKLNTAISNLEVEnkdvksrtllsvpgYDEkvEFGVLTSFAYPVIG-SDEKLIIATTRPETIFGDTAVA 392
Cdd:PLN02943  220 IYQGSYMVNWSPNLQTAVSDLEVE--------------YSE--EPGTLYYIKYRVAGgSEDFLTIATTRPETLFGDVAIA 283
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    393 VHPDDDRYKHLHGKFIQHPF-LPRKIPIITDKEaVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFINILTDDGLLNEECG 471
Cdd:PLN02943  284 VNPEDDRYSKYIGKMAIVPMtYGRHVPIIADRY-VDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTLNEVAG 362
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    472 PEWqgmkrFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDIIEPLLKPQWWVSQSEMAKDAIKVVRDGQITITPKSS 551
Cdd:PLN02943  363 LYW-----FEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKALKAVENGELTIIPERF 437
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    552 EAEYFHWLGNIQDWCISRQLWWGHRCPVYFinIEGEEHDRidgDYWVAgRSMEEAEKKAAAKYPNSkFTLEQDEDVLDTW 631
Cdd:PLN02943  438 EKIYNHWLSNIKDWCISRQLWWGHRIPVWY--IVGKDCEE---DYIVA-RSAEEALEKAREKYGKD-VEIYQDPDVLDTW 510
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    632 FSSGLWPFSTLGWPE-KTKDMETFYPFSMLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQGRKMSKSLGN 710
Cdd:PLN02943  511 FSSALWPFSTLGWPDvSAEDFKKFYPTTVLETGHDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGN 590
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    711 VIDPLDVItgiklddlhakllqgnldprevekakigqkESYpngipqcGTDAMRFALcAYTTGGRDINLDILRVEGYRKF 790
Cdd:PLN02943  591 VIDPLDTI------------------------------KEF-------GTDALRFTL-ALGTAGQDLNLSTERLTSNKAF 632
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    791 CNKIYQATKFALMRLGDDYQPPATEGLSGNE----------SLVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYE-FW 859
Cdd:PLN02943  633 TNKLWNAGKFVLQNLPSQSDTSAWEHILACKfdkeesllslPLPECWVVSKLHELIDSVTTSYDKYFFGDVGREIYDfFW 712
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    860 YLICDVYIENSKY-LIQEGSAIEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQRLPKRsteKAASIVkASYPvYVSEY 938
Cdd:PLN02943  713 SDFADWYIEASKTrLYHSGDNSALSRAQAVLLYVFENILKLLHPFMPFVTEELWQALPYR---KEALIV-SPWP-QTSLP 787
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    939 DDVKSANAYDLVLNITKEARSLLSEYNILKNGKV---FVESNHEEYFKTAEDQkdsIVSLIKAIDEVTVvrDASEIPEGC 1015
Cdd:PLN02943  788 KDLKSIKRFENLQSLTRAIRNARAEYSVEPAKRIsasIVASAEVIEYISKEKE---VLALLSRLDLQNV--HFTDSPPGD 862
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   1016 VLQSVN----PEVNVHLLVKGHVDIDAEIAKVQKKLEKAKKSKNGIEQTINSKDYETKA--------NTQAKEANKsKLD 1083
Cdd:PLN02943  863 ANQSVHlvasEGLEAYLPLADMVDISAEVERLSKRLSKMQTEYDALAARLSSPKFVEKApedvvrgvREKAAEAEE-KIK 941
                         970
                  ....*....|..
gi 6321531   1084 NTVAEIEGLEAT 1095
Cdd:PLN02943  942 LTKNRLAFLKST 953
ValRS_core cd00817
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ...
181-779 0e+00

catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 185677 [Multi-domain]  Cd Length: 382  Bit Score: 589.22  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   181 GVFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIATQSVVEKQIWAKdRKTRHDYGREAFVG 260
Cdd:cd00817    1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIE-GKTRHDLGREEFLE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   261 KVWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGVIYRASRLVNWSVKLNTAISNLEVenkd 340
Cdd:cd00817   80 KCWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV---- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   341 vksrtllsvpgydekvefgvltsfaypvigsdekliiattrpetifgdtavavhpdddrykhlhgkfiqhpflprkipii 420
Cdd:cd00817      --------------------------------------------------------------------------------
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   421 tdkeavdmefgtgavkitpahdqndyntgkrhnlefiniltddgllneecgpewqgmkrfdarkkvieqlkeknlyvgqe 500
Cdd:cd00817      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   501 dnemtiptCSRSGDIIEPLLKPQWWVSQSEMAKDAIKVVRDGQITITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVY 580
Cdd:cd00817  156 --------CSRSGDVIEPLLKPQWFVKVKDLAKKALEAVKEGDIKFVPERMEKRYENWLENIRDWCISRQLWWGHRIPAW 227
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   581 FINiegeehdriDGDYWVAGRSME--EAEKKAAAKYPNSKFTLEQDEDVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFS 658
Cdd:cd00817  228 YCK---------DGGHWVVAREEDeaIDKAAPEACVPCGGEELKQDEDVLDTWFSSSLWPFSTLGWPEETKDLKKFYPTS 298
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   659 MLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQGRKMSKSLGNVIDPLDVITGIklddlhakllqgnldpr 738
Cdd:cd00817  299 LLVTGHDIIFFWVARMIMRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGY----------------- 361
                        570       580       590       600
                 ....*....|....*....|....*....|....*....|.
gi 6321531   739 evekakigqkesypngipqcGTDAMRFALCAYTTGGRDINL 779
Cdd:cd00817  362 --------------------GADALRFTLASAATQGRDINL 382
valS PRK13208
valyl-tRNA synthetase; Reviewed
146-1011 6.22e-154

valyl-tRNA synthetase; Reviewed


Pssm-ID: 237306 [Multi-domain]  Cd Length: 800  Bit Score: 478.15  E-value: 6.22e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    146 KAYNPANVESSWYDWWIKTGVFEpeFTADGKvKPegVFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLP 225
Cdd:PRK13208    8 KKYDPEELEEKWQKIWEEEGTYK--FDPDER-KP--VYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQ 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    226 GFDHAGIATQSVVEKQ--IwakdrkTRHDYGREAFVGKVWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEE 303
Cdd:PRK13208   83 GWDDNGLPTERKVEKYygI------RKDDISREEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQK 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    304 AFVRLHDEGVIYRASRLVNWSVKLNTAISNLEVENKDVKsrtllsvpgydekvefGVLTSFAYPViGSDEKLIIATTRPE 383
Cdd:PRK13208  157 SFLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYRERE----------------GKLNYIKFPV-EDGEEIEIATTRPE 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    384 TIFGDTAVAVHPDDDRYKHLHGKFIQHPFLPRKIPIITDkEAVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFINILTDD 463
Cdd:PRK13208  220 LLPACVAVVVHPDDERYKHLVGKTAIVPLFGVEVPILAD-PLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIIIDED 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    464 GLLNEECGpEWQGMKRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGDIIEPLLKPQWWVSQSEMAKDAIKVVRdgQ 543
Cdd:PRK13208  299 GRMTEAAG-KLAGLTIEEARKKIVEDLKSGGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLERGK--E 375
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    544 ITITPKSSEAEYFHWLGNIQ-DWCISRQLWWGHRCPVYFINIEGEEHDRIDGDYWVAGRSmeeaekKAAAKYPNSK---F 619
Cdd:PRK13208  376 INWYPEHMRVRLENWIEGLNwDWCISRQRYFGTPIPVWYCKDCGHPILPDEEDLPVDPTK------DEPPGYKCPQcgsP 449
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    620 TLEQDEDVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFSMLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDA 699
Cdd:PRK13208  450 GFEGETDVMDTWATSSITPLIVTGWERDEDLFEKVFPMDLRPQGHDIIRTWLFYTILRAYLLTGKLPWKNIMISGMVLDP 529
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    700 QGRKMSKSLGNVIDPLDVItgiklddlhakllqgnldprevekakigqkESYpngipqcGTDAMRFALcAYTTGGRDINL 779
Cdd:PRK13208  530 DGKKMSKSKGNVVTPEELL------------------------------EKY-------GADAVRYWA-ASARLGSDTPF 571
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    780 DILRVEGYRKFCNKIYQATKFALMrLGDDYQPPATEGLsgneSLVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYEF- 858
Cdd:PRK13208  572 DEKQVKIGRRLLTKLWNASRFVLH-FSADPEPDKAEVL----EPLDRWILAKLAKVVEKATEALENYDFAKALEEIESFf 646
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    859 WYLICDVYIENSKY-LIQEGSAIEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQRLPKRstekaaSIVKASYPVYVSE 937
Cdd:PRK13208  647 WHVFCDDYLELVKSrAYGEDEEEEQKSARYTLYTVLDTLLRLLAPFLPFITEEVWSWLYGG------SVHRASWPEPDEE 720
                         810       820       830       840       850       860       870
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6321531    938 YDDVKSANAYDLVLNITKEARSLLSEYNILKNGKV-FVESNHEEYFKTAEDQKDSIVSLIKaIDEVTVVRDASEI 1011
Cdd:PRK13208  721 LIDEEDEELGELAKEILSAVRKYKSEAGLSLNAPLkKVEVYGPADLELLEAAEEDLKAAGN-IEELELVEGDPEL 794
IleS COG0060
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ...
148-1031 2.48e-107

Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439830 [Multi-domain]  Cd Length: 931  Bit Score: 357.85  E-value: 2.48e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   148 YNPANVESSWYDWWIKTGVFE---------PEFT-ADGkvkpegvfcipapPPNVTGALHIGHALTIAIQDSLIRYNRMK 217
Cdd:COG0060   16 ANLPKREPEILKFWEENDIYEksrearagrPKFVlHDG-------------PPYANGDIHIGHALNKILKDIIVRYKTMR 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   218 GKTVLFLPGFD-HaG--IATQsvVEKQIwAKDRKTRHDYGREAFVGK----VWEWKEEYhsriKNQIQKLGASYDWSREA 290
Cdd:COG0060   83 GFDVPYVPGWDcH-GlpIELK--VEKEL-GIKKKDIEKVGIAEFREKcreyALKYVDEQ----REDFKRLGVWGDWDNPY 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   291 FTLSPELTKSVEEAFVRLHDEGVIYRASRLVNWSVKLNTAISNLEVENKDVKSRTLlsvpgYdekVEFGVLTSFAyPVIG 370
Cdd:COG0060  155 LTMDPEYEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEYKDVTSPSI-----Y---VKFPVKDEKA-LLLL 225
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   371 SDEKLIIATTRPETIFGDTAVAVHPD----------DDRY---------------------------KHLHGKFIQHPFL 413
Cdd:COG0060  226 EDAYLVIWTTTPWTLPANLAVAVHPDidyvlvevtgGERLilaealveavlkelgiedyevlatfkgAELEGLRYEHPFY 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   414 -----PRKIPIITDkEAVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFINILTDDGLLNEEcGPEWQGMKRFDARKKVIE 488
Cdd:COG0060  306 yvvgyDRAHPVILG-DYVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTEE-APLFAGLFVKDANPAIIE 383
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   489 QLKEKNLYVGQEdnemTI----PTCSRSGdiiEPLL---KPQWWVSQSEMAKDAIKVVRdgQITITPKSSEAEYFHWLGN 561
Cdd:COG0060  384 DLKERGALLARE----KIthsyPHCWRCK---TPLIyraTPQWFISMDKLRDRALEAIE--KVNWIPEWGEGRFGNMLEN 454
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   562 IQDWCISRQLWWG-------HRCP--------VYF-----INIEGEE-------HDR-IDGDYwvagrsmeeaekkaaaK 613
Cdd:COG0060  455 RPDWCISRQRYWGvpipiwvCEDCgelhrteeVIGsvaelLEEEGADawfeldlHRPfLDETL----------------K 518
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   614 YPNSKFTLEQDEDVLDTWFSSGLWPFSTLgwpeKTKDmETFYPFSM-LE-----TGWdilfFWVtrMILLGLKLTGSVPF 687
Cdd:COG0060  519 CPKCGGTMRRVPDVLDVWFDSGSMHFAVL----ENRE-ELHFPADFyLEgsdqtRGW----FYS--SLLTSTALFGRAPY 587
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   688 KEVFCHSLVRDAQGRKMSKSLGNVIDPLDVItgiklddlhakllqgnldprevekakigqkESYpngipqcGTDAMRFAL 767
Cdd:COG0060  588 KNVLTHGFVLDEDGRKMSKSLGNVVDPQEVI------------------------------DKY-------GADILRLWV 630
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   768 CAYTTGGrDINL--DILR--VEGYRKfcnkIYQATKFALMRLgDDYQPpATEGLSGNE-SLVEKWILHKLTETSKIVNEA 842
Cdd:COG0060  631 ASSDYWG-DLRFsdEILKevRDVYRR----LRNTYRFLLANL-DDFDP-AEDAVPYEDlPELDRWILSRLNELIKEVTEA 703
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   843 LDKRDFLTSTSSIYEF-------WYLicDV-----YIEnskyliqEGSAIEKKSAKDTLYILLDNALKLIHPFMPFISEE 910
Cdd:COG0060  704 YDNYDFHRAYRALHNFcvedlsnWYL--DIskdrlYTE-------AADSLDRRAAQTTLYEVLETLVRLLAPILPFTAEE 774
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   911 MWQRLPKrstEKAASIVKASYPVYVSEYDDVKSANAYDLVLNITKEARSLLSEY---NILKN--GKVFVESNHEEYFKTA 985
Cdd:COG0060  775 IWQNLPG---EAEESVHLADWPEVDEELIDEELEAKWDLVREVRSAVLKALEAArkeKLIRQplEAAVVLYADEELAAAL 851
                        970       980       990      1000      1010
                 ....*....|....*....|....*....|....*....|....*....|.
gi 6321531   986 EDQKD-----SIVSlikaidEVTVVRDASEIPEGCVLQSVNPEVNVHLLVK 1031
Cdd:COG0060  852 ESLGDllaeeLNVS------EVELVDDAEDLGKDALKALDVEGISVTVEVE 896
Ile_Leu_Val_MetRS_core cd00668
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ...
182-718 7.35e-59

catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.


Pssm-ID: 185674 [Multi-domain]  Cd Length: 312  Bit Score: 204.96  E-value: 7.35e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   182 VFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIATQSVVEKqIWAKDRKTRHdygREAFVGK 261
Cdd:cd00668    1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAER-KGGRKKKTIW---IEEFRED 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   262 VWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGVIYRASRLVnwsvklntaisnlevenkdv 341
Cdd:cd00668   77 PKEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHPV-------------------- 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   342 ksrtllsvpgydekvefgvltsfaypvigsdekliiattrpetifgdtavavhpdddrykhlhgkfiqhpflprkipIIT 421
Cdd:cd00668  137 -----------------------------------------------------------------------------RIT 139
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   422 DKEAVDMefgtgavkitpahdqndyntgkrhnlefiniltddgllneecgPEWqgmkrfdaRKKVIEQLKEKNlyvgqed 501
Cdd:cd00668  140 EQWFFDM-------------------------------------------PKF--------KEKLLKALRRGK------- 161
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   502 nemtiptcsrsgdiieplLKPQWWvsqsemakdaikvvrdgqititpkssEAEYFHWLGNIQDWCISRQLWWGHRCPvyf 581
Cdd:cd00668  162 ------------------IVPEHV--------------------------KNRMEAWLESLLDWAISRQRYWGTPLP--- 194
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   582 iniegeehdridgdywvagrsmeeaekkaaakypnskftleqdEDVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFSMLE 661
Cdd:cd00668  195 -------------------------------------------EDVFDVWFDSGIGPLGSLGYPEEKEWFKDSYPADWHL 231
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 6321531   662 TGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQGRKMSKSLGNVIDPLDVI 718
Cdd:cd00668  232 IGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVV 288
PLN02843 PLN02843
isoleucyl-tRNA synthetase
160-961 1.63e-54

isoleucyl-tRNA synthetase


Pssm-ID: 215452 [Multi-domain]  Cd Length: 974  Bit Score: 206.55  E-value: 1.63e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    160 WWIKTGVFEPEFT-ADGkvkpeGVFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIATQSVV 238
Cdd:PLN02843   15 LWEENQVYKRVSDrNNG-----ESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIELKV 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    239 EKQIwakDRKTRHDYGREAFVGKVWEWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGVIYRAS 318
Cdd:PLN02843   90 LQSL---DQEARKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGR 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    319 RLVNWSVKLNTAISNLEVEnkdvksrtllsvpgYDEKvefGVLTSF--AYPVIGSDEK-------------LIIATTRPE 383
Cdd:PLN02843  167 KPVHWSPSSRTALAEAELE--------------YPEG---HVSKSIyvAFPVVSPSETspeeleeflpglsLAIWTTTPW 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    384 TIFGDTAVAVHPDDD--------------------------RYKHLHGKFI----------------------------- 408
Cdd:PLN02843  230 TMPANAAVAVNDKLQysvvevqsfsedestsggnkkkrpgnVLKEQQKLFLivatdlvpaleakwgvklvvlktfpgsdl 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    409 -----QHPFLPRKIPIITDKEAVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFINILTDDGLLNEECGPeWQGMKRF-DA 482
Cdd:PLN02843  310 egcryIHPLYNRESPVVIGGDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQ-FSGLSVLgEG 388
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    483 RKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGdiiepllKP-------QWWVSQSEMAKDAIKVVRdgQITITPKSSEAEY 555
Cdd:PLN02843  389 NAAVVEALDEAGSLLMEEAYGHKYPYDWRTK-------KPtifrateQWFASVEGFRQAALDAID--KVKWIPAQGENRI 459
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    556 FHWLGNIQDWCISRQLWWGHRCPVyFINIEGEE----HDRID----------GDYWvagRSMeEAEKKAAAKYPNSKFTL 621
Cdd:PLN02843  460 RAMVSGRSDWCISRQRTWGVPIPV-FYHVETKEplmnEETIAhvksivaqkgSDAW---WYM-DVEDLLPEKYRDKASDY 534
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    622 EQDEDVLDTWFSSGlwpfSTLGWPEKTKDmETFYPFSMLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQG 701
Cdd:PLN02843  535 EKGTDTMDVWFDSG----SSWAGVLGSRE-GLSYPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKG 609
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    702 RKMSKSLGNVIDPLDVITGIKlddlhakllqgnldprevekakiGQKESypngiPQCGTDAMRF--ALCAYtTGGRDINL 779
Cdd:PLN02843  610 FKMSKSLGNVVDPRLVIEGGK-----------------------NQKQE-----PAYGADVLRLwvASVDY-TGDVLIGP 660
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    780 DILR--VEGYRKFCNKIyqatKFALMRLGdDYQPpaTEGLSgNESL--VEKWILHKLTETSKIVNEALDKRDFLTSTSSI 855
Cdd:PLN02843  661 QILKqmSDIYRKLRGTL----RYLLGNLH-DWKP--DNAVP-YEDLpsIDKYALFQLENVVNEIEESYDNYQFFKIFQIL 732
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    856 YEFWYL-ICDVYIENSK---YlIQEGSAIEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQRLP-KRSTEKAASIVKAS 930
Cdd:PLN02843  733 QRFTIVdLSNFYLDVAKdrlY-VGGTTSFTRRSCQTVLAAHLLSLLRAIAPILPHLAEDAWQNLPfQEDGSAAESVFEAG 811
                         890       900       910
                  ....*....|....*....|....*....|...
gi 6321531    931 YPVYVSEYDDVKSANA--YDLVLNITKEARSLL 961
Cdd:PLN02843  812 WPTPNEEWLSFPAEDVdfWSLLLEVRDEVNKVL 844
Anticodon_Ia_Val cd07962
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ...
779-915 8.56e-54

Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.


Pssm-ID: 153416 [Multi-domain]  Cd Length: 135  Bit Score: 183.91  E-value: 8.56e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   779 LDILRVEGYRKFCNKIYQATKFALMRLGDDYQPPATEGlsgNESLVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYEF 858
Cdd:cd07962    1 FDEKRVEGGRNFCNKLWNAARFVLMNLEDDDEPEEDPE---SLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEF 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 6321531   859 -WYLICDVYIENSKYLIQEGSAIEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQRL 915
Cdd:cd07962   78 fWNDFCDWYLELVKPRLYGEDEEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
leuS_bact TIGR00396
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ...
148-935 2.43e-44

leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273057 [Multi-domain]  Cd Length: 842  Bit Score: 173.78  E-value: 2.43e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     148 YNPANVESSWYDWWIKTGVFEpeFTADGKVKPEGVFCI-PAPppnvTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPG 226
Cdd:TIGR00396    1 YNHIEIEEKWQQKWDENKTFK--VTDDSSKPKYYILSMfPYP----SGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIG 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     227 FDHAGI-ATQSVVEKQIWAKDrktrhdygreafvgkvweWKEEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAF 305
Cdd:TIGR00396   75 WDAFGLpAENAAIKRGIHPAK------------------WTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIF 136
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     306 VRLHDEGVIYRASRLVNWSVKLNTAISNLEVENKDVKSRTLLSVPGYDEKVEFGVLTSFA-------------------- 365
Cdd:TIGR00396  137 LELFEKGLAYVKEADVNWCPNDGTVLANEQVDSDGRSWRGDTPVEKKELKQWFLKITAYAeellndleeldhwpesvkem 216
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     366 --------------YPVIGSDEKLIIATTRPETIFGDTAVAVHPDDDRYKHLH------GKFIQ---------------- 409
Cdd:TIGR00396  217 qrnwigksegveitFKIADHDEKITVFTTRPDTIFGVTYLALAPEHPLVEKAAennpkvAAFIKkilnktvaertkatke 296
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     410 -----------HPFLPRKIPIITDKEAVdMEFGTGAVKITPAHDQNDYNTGKRHNLEFIN-ILTDDGLLNEECGP----- 472
Cdd:TIGR00396  297 kkgvdtgikaiHPLTGEKIPIWVANYVL-MEYGTGAVMGVPAHDERDFEFAQKYGLPIKPvIDPAEKDLSLTAAYtedgv 375
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     473 -----EWQGMKRFDARKKVIEQLKEKNLyvgqednemtiptcsrsgdiiepllkpqwwvsqsemakdaikvvrdGQITIT 547
Cdd:TIGR00396  376 lvnsgEFNGLNSSEARNAIIDMLEKEGK----------------------------------------------GKRKVN 409
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     548 PKsseaeyfhwlgnIQDWCISRQLWWGHRCPVYFIN-------------IEGEEHDRIDGDywvAGRSMEEAEKKAAAKY 614
Cdd:TIGR00396  410 YR------------LRDWGFSRQRYWGEPIPIIHCEdggvvpvpeedlpVILPEDVVYDGD---GGSPLSRIPEWVNVTC 474
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     615 PNSKFTLEQDEDVLDTWFSSGlWPFSTLGWPEKTKDM------ETFYPFSMLETGWD-----ILF--FWVTRMILLGLkL 681
Cdd:TIGR00396  475 PSCGKPALRETDTMDTFAGSS-WYYLRYLDPKNTDGPfdkekaEYWLPVDLYIGGIEhailhLLYarFFHKFLRDIGY-V 552
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     682 TGSVPFKEVFCHSLV-----------------------RDAQGR--------KMSKSLGNVIDPLDVItgiklddlhakl 730
Cdd:TIGR00396  553 NTKEPFKKLINQGMVlgfyyppngkvpadvlterdekgKDKAGGelvyvgyeKMSKSKGNGIDPQEIV------------ 620
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     731 lqgnldprevekakigqkESYpngipqcGTDAMRFALCAYTTGGRDINLDILRVEGYRKFCNKIYqatkfalmRLGDDYQ 810
Cdd:TIGR00396  621 ------------------ESY-------GADALRLFIMFMGPIAASLEWNESGLEGARRFLDRVW--------NLVYEIT 667
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     811 PPATEGLSGNESL--VEKWILHKLTETSKIVNEALDKR-DFLTSTSSIYEFwylICDVYIENSKYLIQEGsaiekksakd 887
Cdd:TIGR00396  668 GELDAASLTVTALeeAQKELRRDVHKFLKKVTEDLEKReSFNTAISAMMEL---LNKLYKAKKEALMLEY---------- 734
                          890       900       910       920
                   ....*....|....*....|....*....|....*....|....*....
gi 6321531     888 tlyilLDNALKLIHPFMPFISEEMWQRL-PKRSTEKAASIVKASYPVYV 935
Cdd:TIGR00396  735 -----LKGFVTVLSPFAPHLAEELWEKLgSEPFIIDNAKWPVVDETALV 778
LeuS COG0495
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ...
146-934 3.36e-39

Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440261 [Multi-domain]  Cd Length: 826  Bit Score: 157.52  E-value: 3.36e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   146 KAYNPANVESSWYDWWIKTGVFEPEfTADGKVKpegVFCI---PAPppnvTGALHIGHALTIAIQDSLIRYNRMKGKTVL 222
Cdd:COG0495    3 ERYNPKEIEKKWQKYWEENGTFKAD-EDSSKPK---YYVLdmfPYP----SGRLHMGHVRNYTIGDVVARYKRMQGYNVL 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   223 FlP-GFD-------HAGIATQSvvekqiwakdrktrHDYgreafvgkvwEWKEEYHSRIKNQIQKLGASYDWSREAFTLS 294
Cdd:COG0495   75 H-PmGWDafglpaeNAAIKNGV--------------HPA----------EWTYENIANMRRQLKRLGLSYDWSREIATCD 129
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   295 PELTKSVEEAFVRLHDEGVIYRASRLVNWSVKLNTAISNLEVENK-------DVKSR---------T-----LLS----V 349
Cdd:COG0495  130 PEYYKWTQWIFLQLYEKGLAYRKEAPVNWCPVDQTVLANEQVIDGrcwrcgaPVEKKelpqwflkiTdyadeLLDdldkL 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   350 PGYDEKV----------EFGVltSFAYPVIGSDEKLIIATTRPETIFGDTAVAV---HP--------------------- 395
Cdd:COG0495  210 DGWPEKVktmqrnwigrSEGA--EVDFPVEGSDEKITVFTTRPDTLFGATFMVLapeHPlvkelatpeqnaavaafieea 287
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   396 ---------DDDRYKH--LHGKFIQHPFLPRKIPI-ITDkeAVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFINIL--- 460
Cdd:COG0495  288 kkkseiertSETKEKTgvFTGLYAINPLTGEKIPIwIAD--YVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIape 365
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   461 ------------TDDG-LLNEEcgpEWQGMKRFDARKKVIEQLKEKNLyvgqednemtiptcsrsgdiiepllkpqwwvs 527
Cdd:COG0495  366 dgddpdileeayTGDGvLINSG---EFDGLDSEEAKEAIIEWLEEKGL-------------------------------- 410
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   528 qsemakdaikvvrdGQITITPKsseaeyfhwlgnIQDWCISRQLWWGhrCPVYFINIE--GE-------------EHDRI 592
Cdd:COG0495  411 --------------GKRKVNYR------------LRDWLISRQRYWG--EPIPIIHCEdcGVvpvpedqlpvelpEDVDF 462
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   593 DGDywvaGRSmeeaekkaaakyPnskftLEQDE------------------DVLDTWF-SSglW-------------PFS 640
Cdd:COG0495  463 DPT----GGS------------P-----LARAPewvnvtcpkcggparretDTMDTFVdSS--WyylrytdphndeaPFD 519
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   641 tlgwPEKTKDmetfypfsmletgW---D---------IL------FFwvTR-MILLGLkLTGSVPFKEVFCHSLVRD--- 698
Cdd:COG0495  520 ----PEAANY-------------WlpvDqyiggiehaILhllyarFF--TKvLRDLGL-VSFDEPFKRLLTQGMVLEvgk 579
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   699 -----AQGRKMSKSLGNVIDPLDVItgiklddlhakllqgnldprevekakigqkESYpngipqcGTDAMR-FALCA--- 769
Cdd:COG0495  580 dgvviGGIEKMSKSKGNVVDPDEII------------------------------EKY-------GADTLRlFEMFAgpp 622
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   770 -----YTTGGrdinldilrVEGYRKFCNKIYqatkfalmRLGDDYQ---PPATEGLSGNESLVEKwILHKlteTSKIVNE 841
Cdd:COG0495  623 erdleWSDSG---------VEGAYRFLNRVW--------RLVVDEAealKLDVADLSEADKELRR-ALHK---TIKKVTE 681
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   842 ALDKRDFLTSTSSIYEFwylicdVyieNSKYLIQEGSAIEKKSAKDTLYILldnaLKLIHPFMPFISEEMWQRLpkrstE 921
Cdd:COG0495  682 DIERLRFNTAIAALMEL------V---NALYKAKDSGEADRAVLREALETL----VLLLAPFAPHIAEELWERL-----G 743
                        970
                 ....*....|...
gi 6321531   922 KAASIVKASYPVY 934
Cdd:COG0495  744 HEGSVADAPWPEA 756
PLN02882 PLN02882
aminoacyl-tRNA ligase
146-934 2.07e-38

aminoacyl-tRNA ligase


Pssm-ID: 215477 [Multi-domain]  Cd Length: 1159  Bit Score: 156.04  E-value: 2.07e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    146 KAYNPANVESSWYDWWIKTGVFEPEFTADgKVKPEGVFCipAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLP 225
Cdd:PLN02882    6 KDFSFPKQEEKILSLWSEIDAFKTQLKRT-EGLPEYIFY--DGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    226 GFDHAGIATQSVVEKQIWAKDRKTRHDYG----REAFVGKVWEWKEEYHSRIKnqiqKLGASYDWSREAFTLSPELTKSV 301
Cdd:PLN02882   83 GWDCHGLPVEYEIDKKLGIKRRDDVLKMGidkyNEECRSIVTRYSKEWEKTVT----RTGRWIDFENDYKTMDPKFMESV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    302 EEAFVRLHDEGVIYRASRLVNWSVKLNTAISNLEV--ENKDVKSrtllsvpgydekveFGVLTSFayPVIGSDEK--LII 377
Cdd:PLN02882  159 WWVFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEAglNYKDVSD--------------PAVMVSF--PIVGDPDNasFVA 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    378 ATTRPETIFGDTAVAVHPDDDrYKHLHGKFIQHPFL---PR--KIPIITDK-----------------------EAVD-- 427
Cdd:PLN02882  223 WTTTPWTLPSNLALCVNPNFT-YVKVRNKYTGKVYIvaeSRlsALPTAKPKskkgskpenaaegyevlakvpgsSLVGkk 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    428 --------MEF-----------------GTGAVKITPAHDQNDYNTGKRHNL-----EFINILTDDGLLNEECgPEWQGM 477
Cdd:PLN02882  302 yeplfdyfSEFsdtafrvvaddyvtddsGTGVVHCAPAFGEDDYRVCLANGIiekggNLPVPVDDDGCFTEKV-TDFSGR 380
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    478 KRFDARKKVIEQLKEKNLYVGQEDNEMTIPTCSRSGdiiEPLLK---PQWWVSQSEMaKDAIkVVRDGQITITPKSSEAE 554
Cdd:PLN02882  381 YVKDADKDIIAAIKAKGRLVKSGSITHSYPFCWRSD---TPLIYravPSWFVKVEEI-KDRL-LENNKQTYWVPDYVKEK 455
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    555 YFH-WLGNIQDWCISRQLWWGHRCPVYfINIEGEEHDRIDGDYWVAGRSMEEAE-----KKAAAKYPNSK---FT-LEQD 624
Cdd:PLN02882  456 RFHnWLENARDWAVSRSRFWGTPLPIW-ISDDGEEVVVIGSIAELEKLSGVKVTdlhrhFIDHITIPSSRgpeFGvLRRV 534
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    625 EDVLDTWFSSGLWPFSTLGWPEKTKDM-ETFYPFSMLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQGRK 703
Cdd:PLN02882  535 DDVFDCWFESGSMPYAYIHYPFENKELfEKNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKK 614
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    704 MSKSLGNVIDPLDVITgiklddlhakllqgnldprevekakigqkesypngipQCGTDAMRFALcayttggrdINLDILR 783
Cdd:PLN02882  615 MSKSLKNYPDPNEVID-------------------------------------KYGADALRLYL---------INSPVVR 648
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    784 VEGYRkFCNK------------IYQATKFALM---RL----GDDYQPPATEGLSGNESLVEKWILHKLTETSKIVNEALD 844
Cdd:PLN02882  649 AEPLR-FKEEgvfgvvkdvflpWYNAYRFLVQnakRLevegGAPFVPLDLAKLQNSANVLDRWINSATQSLVKFVREEMG 727
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    845 KRDFLTSTSSIYEFWYLICDVYIE-NSKYLIQEGSAIEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQRLPKRSTEKA 923
Cdd:PLN02882  728 AYRLYTVVPYLVKFIDNLTNIYVRfNRKRLKGRTGEEDCRTALSTLYNVLLTSCKVMAPFTPFFTEVLYQNLRKVLPGSE 807
                         890
                  ....*....|.
gi 6321531    924 ASIVKASYPVY 934
Cdd:PLN02882  808 ESIHYCSFPQV 818
leuS PRK12300
leucyl-tRNA synthetase; Reviewed
196-999 4.33e-37

leucyl-tRNA synthetase; Reviewed


Pssm-ID: 237049 [Multi-domain]  Cd Length: 897  Bit Score: 151.17  E-value: 4.33e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    196 LHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFdHA------GIAtqsvveKQIWAKDRKTRHDYGREAFVGKVWEWK--- 266
Cdd:PRK12300    1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAF-HVtgtpilGIA------ERIARGDPETIELYKSLYGIPEEELEKfkd 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    267 -----EEYHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGVIYRASRLVNWSVKLNTAisnleVENKDV 341
Cdd:PRK12300   74 peyivEYFSEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNP-----VGDHDL 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    342 KsrtllsvpgYDEKVEFG--VLTSFaypvIGSDEKLII-ATTRPETIFGDTAVAVHPD--------DDRY---------- 400
Cdd:PRK12300  149 L---------DGEEPEIVeyTLIKF----EESEDLILPaATLRPETIFGVTNLWVNPDatyvkaevDGEKwivskeaaek 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    401 ----------------KHLHGKFIQHPFLPRKIPIItdkEA--VDMEFGTGAVKITPAHDQNDY--------NTGKRHNL 454
Cdd:PRK12300  216 lsfqdrdveiieeikgSELIGKKVKNPVTGKEVPIL---PAdfVDPDNGTGVVMSVPAHAPYDYvalrdlkkNKELLDVI 292
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    455 EFINILT---------------------DD-----------------GLLNEECGpEWQGMKRFDARKKVIEQLKEKNLY 496
Cdd:PRK12300  293 EPIPLIEvegygefpakevveklgiksqEDpeleeatkevyraefhkGVLKENTG-EYAGKPVREAREKITKDLIEKGIA 371
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    497 -VGQEdnEMTIPTCSRSG-DIIEPLLKPQWWVSQS-----EMAKDAIKvvrdgQITITPKSSEAEYFHWLGNIQDWCISR 569
Cdd:PRK12300  372 dIMYE--FSNRPVYCRCGtECVVKVVKDQWFIDYSdpewkELAHKALD-----NMEIIPEEYRKEFENTIDWLKDRACAR 444
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    570 QLWWGHRCP-----------------VYFINIEGEEHDRIDG--------DYWVAGrsmeeaekkaaakypnsKFTLEQD 624
Cdd:PRK12300  445 RRGLGTRLPwdeewiieslsdstiymAYYTIAHKIREYGIKPeqltpeffDYVFLG-----------------KGDPEEV 507
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    625 EDVldtwfssglwpfstLGWPEKT-----KDMETFYPFSMLETGWD-----ILFF------------WVTRMILLGLKLT 682
Cdd:PRK12300  508 SKK--------------TGIPKEIleemrEEFLYWYPVDWRHSGKDlipnhLTFFifnhvaifpeekWPRGIVVNGFVLL 573
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    683 GsvpfkevfchslvrdaqGRKMSKSLGNVIDPLDVItgiklddlhakllqgnldprevekakigqkESYpngipqcGTDA 762
Cdd:PRK12300  574 E-----------------GKKMSKSKGNVIPLRKAI------------------------------EEY-------GADV 599
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    763 MRFALCAYTTGGRDINLDILRVEGYRKFCNKIYQatkfaLMRLGDDYqppateGLSGNESLVEKWILHKLTETSKIVNEA 842
Cdd:PRK12300  600 VRLYLTSSAELLQDADWREKEVESVRRQLERFYE-----LAKELIEI------GGEEELRFIDKWLLSRLNRIIKETTEA 668
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    843 LDK---RDFLtsTSSIYEF-----WYLicdvyienskyliqegsAIEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQR 914
Cdd:PRK12300  669 MESfqtRDAV--QEAFYELlndlrWYL-----------------RRVGEANNKVLREVLEIWIRLLAPFTPHLAEELWHK 729
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    915 LpkrstEKAASIVKASYPVYVSEYDDVKSANAYDLVLNITKEARSLLSEYNIlKNGKVFVESNHEEYFKTAEDQKDSIV- 993
Cdd:PRK12300  730 L-----GGEGFVSLEKWPEPDESKIDEEAELAEEYVKRLIEDIREILKVAKI-KPKKVYIYVAPDWKYEVLEIAAENGDv 803

                  ....*..
gi 6321531    994 -SLIKAI 999
Cdd:PRK12300  804 kEAIKEL 810
IleRS_core cd00818
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ...
189-718 1.89e-33

catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173909 [Multi-domain]  Cd Length: 338  Bit Score: 132.36  E-value: 1.89e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   189 PPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIATQSVVEKQIWAKDRKTRHDYGREAFVGKVWEWKEE 268
Cdd:cd00818    9 PPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMGIAEFNAKCREFALR 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   269 YHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGVIYRASRLVNWsvklntaisnlevenkdvksrtlls 348
Cdd:cd00818   89 YVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW------------------------- 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   349 vpgydekvefgvltsfayPVIgsdeklIIATtrpetifgdtavavhpdddrykhlhgkfiqhpflprkipiitdkeavdm 428
Cdd:cd00818  144 ------------------PLI------YRAT------------------------------------------------- 150
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   429 efgtgavkitpahdqndyntgkrhnlefiniltddgllneecgpewqgmkrfdarkkvieqlkeknlyvgqednemtipt 508
Cdd:cd00818      --------------------------------------------------------------------------------
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   509 csrsgdiiepllkPQWWVSQSEMAKDAIKVVRdgQITITPKSSEAEYFHWLGNIQDWCISRQLWWGHRCPVYFINIEGEE 588
Cdd:cd00818  151 -------------PQWFIRVTKIKDRLLEAND--KVNWIPEWVKNRFGNWLENRRDWCISRQRYWGTPIPVWYCEDCGEV 215
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   589 HDRidgdywvagrsmeeaekkaaakypnskftleQDEDVLDTWFSSGLWPFSTLGWPEKTKDMETFYPFSMLETGWDILF 668
Cdd:cd00818  216 LVR-------------------------------RVPDVLDVWFDSGSMPYAQLHYPFENEDFEELFPADFILEGSDQTR 264
                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|
gi 6321531   669 FWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQGRKMSKSLGNVIDPLDVI 718
Cdd:cd00818  265 GWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVV 314
PTZ00427 PTZ00427
isoleucine-tRNA ligase, putative; Provisional
189-915 9.61e-33

isoleucine-tRNA ligase, putative; Provisional


Pssm-ID: 173617 [Multi-domain]  Cd Length: 1205  Bit Score: 138.18  E-value: 9.61e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    189 PPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIATQSVVEKQIWAKDRKTRHDYGREAFVGKVWEWKEE 268
Cdd:PTZ00427  110 PPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPIEYEIEKENNINKKEDILKMGIDVYNEKCRGIVLK 189
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    269 YHSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGVIYRASRLVNWSVKLNTAISNLEVE--NKD------ 340
Cdd:PTZ00427  190 YSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNNYVYKSFKVMPYSCKCNTPISNFELNlnYKDtpdpsi 269
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    341 VKSRTLLS----------------------VPGYDEKVEFG------------------------------------VLT 362
Cdd:PTZ00427  270 IISFVLCSdfpkveeecnieedkqllgekySVLYNNKRENSnngnnnstnnvcyaqhseilawtttpwtlpsnlalcVNE 349
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    363 SFAYPVI---GSDEKLIIATTRPETIFGDTAVAV------------HPDDDRYKHLHGKFIQ-HPFLPRKIPIITDKEAV 426
Cdd:PTZ00427  350 HFTYLRIhhvKSNRVVIVGECRLEWIMKELKWNVedlkivnrfkgkELKGLRYKPLFTNFYEkYNFKERAYKILADDFVT 429
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    427 DmEFGTGAVKITPAHDQNDYNTGKRHNLE------FINILTDDGLLNEECgPEWQGMKRFDARKKVIEQLKEKNLYVGQE 500
Cdd:PTZ00427  430 D-DAGTGIVHCAPTYGEDDFRVCKKNGVIdpekniFIDPLDANGYFTNEV-EEVQNLYIKEADNVIKKKLKNENRLLSNN 507
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    501 DNEMTIPTCSRSGdiiEPLLK---PQWWVSQSEMAKdaiKVVRDGQIT--ITPKSSEAEYFHWLGNIQDWCISRQLWWGH 575
Cdd:PTZ00427  508 TIVHSYPFCWRSD---TPLIYraiPAWFIRVSNSTN---ELVKNNETTywIPAHIKEKKFHNWIKDAKDWCISRNRYWGT 581
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    576 RCPVY-------FINIEGEEH-DRIDG-----DYWVAGRSMEEAEKKAAAKYPNskftLEQDEDVLDTWFSSGLWPFSTL 642
Cdd:PTZ00427  582 PIPIWadekmetVICVESIKHlEELSGvkninDLHRHFIDHIEIKNPKGKTYPK----LKRIPEVFDCWFESGSMPYAKV 657
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    643 GWP--EKTKDMETFYPFSMLETGWDILFFWVTRMILLGLKLTGSVPFKEVFCHSLVRDAQGRKMSKSLGNVIDPLDVITG 720
Cdd:PTZ00427  658 HYPfsTEKEDFHKIFPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDK 737
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    721 IKLDDLHAKLLqgNLDPREVEKAKIGQKesypnGIPQCgtdAMRFALCAYTTggrdinldilrvegYRKFCNKI--YQAT 798
Cdd:PTZ00427  738 YGADSLRLYLI--NSVAVRAENLKFQEK-----GVNEV---VKSFILPFYHS--------------FRFFSQEVtrYECL 793
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    799 KFALMRLGDDYqppategLSGNESLVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYEFWYLICDVYIENSKYLIQeGS 878
Cdd:PTZ00427  794 NKKQFLFNTDY-------IYKNDNIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFIENLTNWYIRLNRDRMR-GS 865
                         810       820       830
                  ....*....|....*....|....*....|....*....
gi 6321531    879 AIEKKS--AKDTLYILLDNALKLIHPFMPFISEEMWQRL 915
Cdd:PTZ00427  866 LGEENClqSLCTTYRTLHLFTVLMAPFTPFITEYIYQQL 904
Anticodon_1 pfam08264
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ...
825-975 1.85e-31

Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.


Pssm-ID: 400523 [Multi-domain]  Cd Length: 141  Bit Score: 120.20  E-value: 1.85e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     825 EKWILHKLTETSKIVNEALDKRDFLTSTSSIYEF-WYLICDVYIENSKYLIQEGSAIEKksAKDTLYILLDNALKLIHPF 903
Cdd:pfam08264    1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFfWNDLSDWYLELIKDRLYGEEPDSR--AQTTLYEVLETLLRLLAPF 78
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6321531     904 MPFISEEMWQRLpkrstekaaSIVKASYPVyVSEYDDVKSANAYDLVLNITKEARSLLSEYNILKNGKVFVE 975
Cdd:pfam08264   79 MPFITEELWQKE---------SIHLAPWPE-DAELEEAELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVV 140
PLN02563 PLN02563
aminoacyl-tRNA ligase
143-587 9.82e-28

aminoacyl-tRNA ligase


Pssm-ID: 178177 [Multi-domain]  Cd Length: 963  Bit Score: 121.47  E-value: 9.82e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    143 PALKAYNPANVESSWYDWWIKTGVFE-PEFTADGKVKPEGVFCIPAPppnvTGA-LHIGHALTIAIQDSLIRYNRMKGKT 220
Cdd:PLN02563   75 AAKRAYPFHEIEPKWQRYWEENRTFRtPDDVDTSKPKFYVLDMFPYP----SGAgLHVGHPEGYTATDILARYKRMQGYN 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    221 VLFLPGFDHAGI-ATQSVVEKQIWAKDRKTRHDygreafvgkvwewkeeyhSRIKNQIQKLGASYDWSREAFTLSPELTK 299
Cdd:PLN02563  151 VLHPMGWDAFGLpAEQYAIETGTHPKITTLKNI------------------ARFRSQLKSLGFSYDWDREISTTEPEYYK 212
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    300 SVEEAFVRLHDEGVIYRASRLVNWSVKLNTAISNLEVENkDVKSRT------------LLSVPGYDEK------------ 355
Cdd:PLN02563  213 WTQWIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEVVD-GLSERGghpvirkpmrqwMLKITAYADRlledlddldwpe 291
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    356 -----------------VEFGVLtsfAYPVIGSDEKLIIATTRPETIFGDTAVAVHPD---------DDRYKHLH----- 404
Cdd:PLN02563  292 sikemqrnwigrsegaeLDFSVL---DGEGKERDEKITVYTTRPDTLFGATYLVVAPEhpllsslttAEQKEAVEeyvda 368
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    405 ---------------------GKFIQHPFLPRKIPI-ITDkeAVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFINIL-- 460
Cdd:PLN02563  369 asrksdlertelqkektgvftGSYAINPATGEAIPIwVAD--YVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVkp 446
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    461 ------------TDDG-LLNEEC-GPEWQGMKRFDARKKVIEQLKEKNlyvgqednemtiptcsrsgdiiepllkpqwwv 526
Cdd:PLN02563  447 adgneddaekayTGEGvIVNSSSsGLDINGLSSKEAAKKVIEWLEETG-------------------------------- 494
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6321531    527 sqsemakdaikvvrDGQITITPKsseaeyfhwlgnIQDWCISRQLWWGHRCPVYFINIEGE 587
Cdd:PLN02563  495 --------------NGKKKVNYK------------LRDWLFARQRYWGEPIPVVFLEDSGE 529
LeuRS_core cd00812
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ...
185-328 1.20e-19

catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173906 [Multi-domain]  Cd Length: 314  Bit Score: 91.16  E-value: 1.20e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   185 IPAPPPNvtGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAG-----IATQSVVEKQIWAKDRKtrhdygreafv 259
Cdd:cd00812    6 VMFPYPS--GALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGlpaenAAIKIGRDPEDWTEYNI----------- 72
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6321531   260 gkvwewkeeyhSRIKNQIQKLGASYDWSREAFTLSPELTKSVEEAFVRLHDEGVIYRASRLVNWSVKLN 328
Cdd:cd00812   73 -----------KKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWCKLLD 130
Anticodon_Ia_Ile_ABEc cd07961
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ...
788-958 2.22e-17

Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.


Pssm-ID: 153415 [Multi-domain]  Cd Length: 183  Bit Score: 81.06  E-value: 2.22e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   788 RKFCNKIYQATKFAL--MRLgDDYQPPATEGLSGNESLVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYEF------W 859
Cdd:cd07961   11 RKVLLPLWNAYRFFVtyANL-DGFDPGKDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEFideltnW 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   860 YlicdvyIE-NSKYLIQEGSAIEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQRLPKRSTEKAASIVKASYPVYVSEY 938
Cdd:cd07961   90 Y------IRrNRKRFWGEEGDDDKLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNLRRELGDAPESVHLLDWPEVDESL 163
                        170       180
                 ....*....|....*....|
gi 6321531   939 DDVKSANAYDLVLNITKEAR 958
Cdd:cd07961  164 IDEELEEAMELVREIVELGR 183
Anticodon_Ia_Ile_BEm cd07960
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ...
780-956 1.03e-15

Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.


Pssm-ID: 153414 [Multi-domain]  Cd Length: 180  Bit Score: 76.41  E-value: 1.03e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   780 DILR--VEGYRKFCNKIyqatKFALMRLgDDYQPPATEGLSGNESLVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYE 857
Cdd:cd07960    4 EILKqvAEAYRKIRNTF----RFLLGNL-NDFDPAKDAVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNN 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   858 F-------WYLicDV-----YIE--NSKyliqegsaiEKKSAKDTLYILLDNALKLIHPFMPFISEEMWQRLPKRSTEKa 923
Cdd:cd07960   79 FctvdlsaFYL--DIikdrlYCDakDSL---------ERRSAQTVLYHILDALLKLLAPILPFTAEEVWEHLPGEKKEE- 146
                        170       180       190
                 ....*....|....*....|....*....|...
gi 6321531   924 aSIVKASYPVYVSEYDDVKSANAYDLVLNITKE 956
Cdd:cd07960  147 -SVFLEDWPELPEEWKDEELEEKWEKLLALRDE 178
tRNA-synt_1_2 pfam13603
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ...
364-490 4.74e-15

Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.


Pssm-ID: 433342 [Multi-domain]  Cd Length: 185  Bit Score: 74.51  E-value: 4.74e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     364 FAYPVIGSDEKLIIATTRPETIFGDTAVAVHPDDD------RYKHLHGKFIQ---------------------------H 410
Cdd:pfam13603   12 ITFPVEGTDEKIEVFTTRPDTLMGVTFVALAPEHPlveklaEKNPEVAAFIEeckntseiertsetkekegvftglyaiH 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     411 PFLPRKIPI-ITDkeAVDMEFGTGAVKITPAHDQNDYNTGKRHNLEFINIL----------------TDDGLL-NEEcgp 472
Cdd:pfam13603   92 PITGEKIPIwIAN--FVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVIqpedgdldldimteayTEEGILvNSG--- 166
                          170
                   ....*....|....*...
gi 6321531     473 EWQGMKRFDARKKVIEQL 490
Cdd:pfam13603  167 EFDGLDSEEAKEAIIKKL 184
MetG COG0143
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ...
183-915 1.40e-12

Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439913 [Multi-domain]  Cd Length: 544  Bit Score: 71.68  E-value: 1.40e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   183 FCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFD-HaGIATQSVVEKQiwakdrktrhdyGR--EAFV 259
Cdd:COG0143    3 FLVTTAIPYANGPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDeH-GTKIELAAEKE------------GItpQELV 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   260 gkvwewkEEYHSRIKNQIQKLGASYD-WSReafTLSPELTKSVEEAFVRLHDEGVIYRAsrlvnwsvklntaisnleven 338
Cdd:COG0143   70 -------DRIHAEFKELFEKLGISFDnFIR---TTSPEHKELVQEIFQRLYDNGDIYKG--------------------- 118
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   339 kdvksrtllSVPG-YDEKVEfgvltSFaYPvigsdekliiattrpetifgdtavavhpddDRYkhLHGkfiqhpflprKI 417
Cdd:COG0143  119 ---------EYEGwYCPECE-----RF-LP------------------------------DRY--VEG----------TC 141
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   418 PIITDKEAvdmefgtgavkitpAHDQNDYNTGKRHNLEFINILTDDgllneeCG--PEWqgmkrfdarkkvieqLKEKNL 495
Cdd:COG0143  142 PKCGAEDA--------------YGDQCENCGATLEPTELINPRSAI------SGapPEL---------------REEEHY 186
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   496 YVgqednemtiptcsRSGDIIEPLLK-----PQWwvsQSEMAKDAIKVVRDGqititpksseaeyfhwlgnIQDWCISRQ 570
Cdd:COG0143  187 FF-------------RLSKYQDRLLEwieenPDI---QPEVRNEVLSWLKEG-------------------LQDLSISRD 231
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   571 LWWGhrcpvyfinIEgeehdridgdywvagrsmeeaekkaaakYPNskftleqDED-VLDTWF-------SsglwpfSTL 642
Cdd:COG0143  232 FDWG---------IP----------------------------VPG-------DPGkVFYVWFdaligyiS------ATK 261
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   643 GWPEKTK---DMETFYPFSMLET----GWDILFF----WVTrmILLGLKLTgsVPfKEVFCHS--LVRdaqGRKMSKSLG 709
Cdd:COG0143  262 GYADDRGlpeDFEKYWPAPDTELvhfiGKDIIRFhaiiWPA--MLMAAGLP--LP-KKVFAHGflTVE---GEKMSKSRG 333
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   710 NVIDPLDVitgikLDDLHAkllqgnldprevekakigqkesypngipqcgtDAMRFALCAYTTGGRDINLD----ILRVE 785
Cdd:COG0143  334 NVIDPDDL-----LDRYGP--------------------------------DALRYYLLREVPFGQDGDFSwedfVARVN 376
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   786 G----------YR--KFCNKiyqatKFalmrlgdDYQPPAteglSGNESLVEKWILHKLTETSKIVNEALDKRDFLTSTS 853
Cdd:COG0143  377 SdlandlgnlaSRtlSMIHK-----YF-------DGKVPE----PGELTEADEELLAEAEAALEEVAEAMEAFEFRKALE 440
                        730       740       750       760       770       780
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6321531   854 SIYEFWYLiCDVYIENSK--YLIQEGsaiEKKSAKDTLYILLdNALK----LIHPFMPFISEEMWQRL 915
Cdd:COG0143  441 EIMALARA-ANKYIDETApwKLAKDE---DPERLATVLYTLL-EALRilaiLLKPFLPETAEKILEQL 503
tRNA-synt_1g pfam09334
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
185-318 8.86e-11

tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.


Pssm-ID: 401322 [Multi-domain]  Cd Length: 387  Bit Score: 65.00  E-value: 8.86e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531     185 IPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIATqsvvekQIWAKDRKTrhdyGREAFVgkvwe 264
Cdd:pfam09334    3 VTTALPYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPI------ELKAEKEGI----TPEELV----- 67
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 6321531     265 wkEEYHSRIKNQIQKLGASYD-WSReafTLSPELTKSVEEAFVRLHDEGVIYRAS 318
Cdd:pfam09334   68 --DRYHEIHREDFKKFNISFDdYGR---TTSERHHELVQEFFLKLYENGYIYEKE 117
PRK11893 PRK11893
methionyl-tRNA synthetase; Reviewed
188-315 1.03e-10

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237012 [Multi-domain]  Cd Length: 511  Bit Score: 65.67  E-value: 1.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    188 PPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFD-HagiatQSVVEKQiwAKDRktrhdyGREAFvgkvwEWK 266
Cdd:PRK11893    8 PIYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDeH-----GQKIQRK--AEEA------GISPQ-----ELA 69
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 6321531    267 EEYHSRIKNQIQKLGASYD-WSReafTLSPELTKSVEEAFVRLHDEGVIY 315
Cdd:PRK11893   70 DRNSAAFKRLWEALNISYDdFIR---TTDPRHKEAVQEIFQRLLANGDIY 116
MetRS_core cd00814
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ...
185-315 1.46e-10

catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.


Pssm-ID: 173907 [Multi-domain]  Cd Length: 319  Bit Score: 63.70  E-value: 1.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   185 IPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIATQSVVEKQiwakdrktrhdyGREafvgkVWE 264
Cdd:cd00814    4 ITTALPYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEE------------GVT-----PQE 66
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 6321531   265 WKEEYHSRIKNQIQKLGASYD-WSReafTLSPELTKSVEEAFVRLHDEGVIY 315
Cdd:cd00814   67 LCDKYHEIFKDLFKWLNISFDyFIR---TTSPRHKEIVQEFFKKLYENGYIY 115
PRK12267 PRK12267
methionyl-tRNA synthetase; Reviewed
192-315 3.99e-09

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237028 [Multi-domain]  Cd Length: 648  Bit Score: 60.58  E-value: 3.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    192 VTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGiatQSVVEKqiwAKDR-KTRHdygreafvgkvwEWKEEYH 270
Cdd:PRK12267   15 PNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHG---QKIQQA---AEKAgKTPQ------------EYVDEIS 76
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 6321531    271 SRIKNQIQKLGASYDwsreAF--TLSPELTKSVEEAFVRLHDEGVIY 315
Cdd:PRK12267   77 AGFKELWKKLDISYD----KFirTTDERHKKVVQKIFEKLYEQGDIY 119
Anticodon_Ia_Leu_AEc cd07959
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ...
813-915 6.96e-09

Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.


Pssm-ID: 153413 [Multi-domain]  Cd Length: 117  Bit Score: 54.90  E-value: 6.96e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   813 ATEGLSGNESLVEKWILHKLTETSKIVNEALDKRDFLTSTSSI-YEF-----WYLicdvyienskyliqegSAIEKKSAK 886
Cdd:cd07959   25 ETEGELEELTFIDRWLLSRLNRLIKETTEAYENMQFREALKEGlYELqndldWYR----------------ERGGAGMNK 88
                         90       100
                 ....*....|....*....|....*....
gi 6321531   887 DTLYILLDNALKLIHPFMPFISEEMWQRL 915
Cdd:cd07959   89 DLLRRFIEVWTRLLAPFAPHLAEEIWHEL 117
Anticodon_Ia_Leu_BEm cd07958
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ...
784-915 2.04e-08

Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.


Pssm-ID: 153412 [Multi-domain]  Cd Length: 117  Bit Score: 53.38  E-value: 2.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   784 VEGYRKFCNKIYqatkfalmRLGDDYQP-PATEGLSGNESLVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYEFwyli 862
Cdd:cd07958    6 VEGAYRFLNRVW--------RLVTELAEaLAAPAAAAELSEEDKELRRKLHKTIKKVTEDIERLRFNTAIAALMEL---- 73
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 6321531   863 cdVyieNSKYLIQEGSAIEKKSAKDTLYILLdnalKLIHPFMPFISEEMWQRL 915
Cdd:cd07958   74 --V---NALYKYKKKDAQHAAVLREALETLV----LLLAPFAPHIAEELWEEL 117
PRK12267 PRK12267
methionyl-tRNA synthetase; Reviewed
640-718 5.27e-07

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237028 [Multi-domain]  Cd Length: 648  Bit Score: 53.65  E-value: 5.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    640 STLGWPEKTKDM-ETFYPFSMLETGWDILFF----WVTRMILLGLKLtgsvpFKEVFCHS-LVRDaqGRKMSKSLGNVID 713
Cdd:PRK12267  237 TALGYGSDDDELfKKFWPADVHLVGKDILRFhaiyWPIMLMALGLPL-----PKKVFAHGwWLMK--DGKMSKSKGNVVD 309

                  ....*
gi 6321531    714 PLDVI 718
Cdd:PRK12267  310 PEELV 314
Anticodon_Ia_like cd07375
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ...
783-904 8.51e-07

Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.


Pssm-ID: 153408 [Multi-domain]  Cd Length: 117  Bit Score: 49.04  E-value: 8.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   783 RVEGYRKFCNKIYQATKFALMRLGDDYQPPATEGLSGneslVEKWILHKLTETSKIVNEALDKRDFLTSTSSIYEF-WYL 861
Cdd:cd07375    3 RLKQARAFLNRLYRLLSFFRKALGGTQPKWDNELLEE----ADRELLARLQEFIKRTTNALEALDPTTAVQELFKFtNEL 78
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 6321531   862 icDVYIENSKYLIQEGSAIEKKSAkdTLYILLDNALKLIHPFM 904
Cdd:cd07375   79 --NWYLDELKPALQTEELREAVLA--VLRAALVVLTKLLAPFT 117
PRK11893 PRK11893
methionyl-tRNA synthetase; Reviewed
663-718 1.40e-06

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237012 [Multi-domain]  Cd Length: 511  Bit Score: 52.19  E-value: 1.40e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6321531    663 GWDILFF----WVTRMILLGLKLtgsvpFKEVFCHS-LVRDaqGRKMSKSLGNVIDPLDVI 718
Cdd:PRK11893  261 GKDILRFhavyWPAFLMAAGLPL-----PKRVFAHGfLTLD--GEKMSKSLGNVIDPFDLV 314
metG PRK00133
methionyl-tRNA synthetase; Reviewed
190-316 4.76e-05

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 234655 [Multi-domain]  Cd Length: 673  Bit Score: 47.45  E-value: 4.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    190 PNVTGALHIGHALTiAIQ-DSLIRYNRMKGKTVLFLPGFDHAGIATQSVVEKQiwakdrktrhdyGR--EAFVgkvwewk 266
Cdd:PRK00133   11 PYANGPIHLGHLVE-YIQaDIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKE------------GItpEELI------- 70
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 6321531    267 EEYHSRIKNQIQKLGASYD-WSReafTLSPELTKSVEEAFVRLHDEGVIYR 316
Cdd:PRK00133   71 ARYHAEHKRDFAGFGISFDnYGS---THSEENRELAQEIYLKLKENGYIYE 118
PLN02959 PLN02959
aminoacyl-tRNA ligase
160-240 1.90e-04

aminoacyl-tRNA ligase


Pssm-ID: 215518 [Multi-domain]  Cd Length: 1084  Bit Score: 45.83  E-value: 1.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    160 WWIKTGVFEPEFTADGKvKPEGVFCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGIATQSVVE 239
Cdd:PLN02959   25 WWEEEKVFEAEAGDEPP-KPGEKFFGNFPYPYMNGLLHLGHAFSLSKLEFAAAYHRLRGANVLLPFAFHCTGMPIKASAD 103

                  .
gi 6321531    240 K 240
Cdd:PLN02959  104 K 104
Anticodon_Ia_Met cd07957
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ...
819-915 1.99e-04

Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.


Pssm-ID: 153411 [Multi-domain]  Cd Length: 129  Bit Score: 42.48  E-value: 1.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   819 GNESLVEKWILHKLTETSKIVNEALDKRDFltsTSSIYEFWYLI--CDVYIENSKY--LIQEGsaiEKKSAKDTLYILLd 894
Cdd:cd07957   32 GGLTEEDEELLEEAEELLEEVAEAMEELEF---RKALEEIMELAraANKYIDETAPwkLAKEE---DPERLATVLYVLL- 104
                         90       100
                 ....*....|....*....|....*
gi 6321531   895 NALK----LIHPFMPFISEEMWQRL 915
Cdd:cd07957  105 ELLRilaiLLSPFMPETAEKILDQL 129
PLN02224 PLN02224
methionine-tRNA ligase
622-741 2.75e-04

methionine-tRNA ligase


Pssm-ID: 177869 [Multi-domain]  Cd Length: 616  Bit Score: 45.09  E-value: 2.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    622 EQDEDVLDTWFSSGLWPFSTLGWPEKTKDMETF----YPFSMLETGWDILFF----WVTRMILLGLKLTgsvpfKEVFCH 693
Cdd:PLN02224  283 DDDKQTIYVWFDALLGYISALTEDNKQQNLETAvsfgWPASLHLIGKDILRFhavyWPAMLMSAGLELP-----KMVFGH 357
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 6321531    694 S-LVRDaqGRKMSKSLGNVIDPLDVITGIKLDDLHAKLLqgnldpREVE 741
Cdd:PLN02224  358 GfLTKD--GMKMGKSLGNTLEPFELVQKFGPDAVRYFFL------REVE 398
PLN02224 PLN02224
methionine-tRNA ligase
183-317 3.62e-03

methionine-tRNA ligase


Pssm-ID: 177869 [Multi-domain]  Cd Length: 616  Bit Score: 41.24  E-value: 3.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531    183 FCIPAPPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAG--IATQSVVEkqiwakdrktrhdyGREAfvg 260
Cdd:PLN02224   71 FVLTTPLYYVNAPPHMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGekIATSAAAN--------------GRNP--- 133
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 6321531    261 kvwewkEEYHSRIKNQIQKLGASYDWSREAF--TLSPELTKSVEEAFVRLHDEGVIYRA 317
Cdd:PLN02224  134 ------PEHCDIISQSYRTLWKDLDIAYDKFirTTDPKHEAIVKEFYARVFANGDIYRA 186
class_I_aaRS_core cd00802
catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA ...
188-265 4.76e-03

catalytic core domain of class I amino acyl-tRNA synthetase; Class I amino acyl-tRNA synthetase (aaRS) catalytic core domain. These enzymes are mostly monomers which aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173901 [Multi-domain]  Cd Length: 143  Bit Score: 38.61  E-value: 4.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   188 PPPNVTGALHIGHALTIAIQDSLIRYNRMKGKTVLFLPGFDHAGiatqsvvEKQIWAKDRKTR-HDYGREAFVGKV---W 263
Cdd:cd00802    4 SGITPNGYLHIGHLRTIVTFDFLAQAYRKLGYKVRCIALIDDAG-------GLIGDPANKKGEnAKAFVERWIERIkedV 76

                 ..
gi 6321531   264 EW 265
Cdd:cd00802   77 EY 78
MetRS_core cd00814
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ...
663-718 9.84e-03

catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.


Pssm-ID: 173907 [Multi-domain]  Cd Length: 319  Bit Score: 39.44  E-value: 9.84e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321531   663 GWDILFF----WVTrmILLGLKLTgsvPFKEVFCHSLVRdAQGRKMSKSLGNVIDPLDVI 718
Cdd:cd00814  242 GKDIIRFhaiyWPA--MLLGAGLP---LPTRIVAHGYLT-VEGKKMSKSRGNVVDPDDLL 295
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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