|
Name |
Accession |
Description |
Interval |
E-value |
| NOP7 |
COG5163 |
Protein required for biogenesis of the 60S ribosomal subunit [Translation, ribosomal structure ... |
1-605 |
0e+00 |
|
Protein required for biogenesis of the 60S ribosomal subunit [Translation, ribosomal structure and biogenesis];
Pssm-ID: 227492 [Multi-domain] Cd Length: 591 Bit Score: 803.91 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 1 MRIKKKNTRGNARNFITRSQAVRKLQVSLADFRRLCIFKGIYPREPRNKKKANKGSTAPTTFYYAKDIQYLMHEPVLAKF 80
Cdd:COG5163 1 MRIKGKNYIGPARKYITRGQAMKKLQLRLADFRRLCILKGVYPREPKNKKKANKGSTAPGTFYYIKDIQYLAHEPVYRKF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 81 REHKTFARKLTRALGRGEVSSAKRLEENRDSYTLDHIIKERYPSFPDAIRDIDDALNMLFLFSNLPSTNQVSSKIINDAQ 160
Cdd:COG5163 81 RENKRFARKLKRALGTGEFEYAKRLEICDEEYGLDHIIKERYPGFGDAVDDIDDALSMLFLFSMLPLTDRISSKIANDAQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 161 KICNQWLAYVAKERLVRKVFVSIKGVYYQANIKGEEVRWLVPFKFPENIPSDVDFRIMLTFLEFYSTLLHFVLYKLYTDS 240
Cdd:COG5163 161 EVCEMFEDYVRRRSLLRKSFMSIKGVYYQATIGGEKVVWFVPYKFPENIPGDVDFRIMLTFLEFYSTLLHFVSLKLYVEE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 241 GLIYPPKLDLKKDKIISGLSSYILEsrqEDSLLkldPTEIEEDVKVESLDASTLKSALNADEANTDetEKEEEQEKKQEK 320
Cdd:COG5163 241 GLDYPPKFDWSKPNFLDGLSSYELE---ESSSL---PTEIEEDVKVESLDSSTLKSAVCNDPGNID--VSKEELSEKIPE 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 321 EQEKEQNEETELDTFEDNNKNKgDILIQPSKYDSPVASLFSAFVFYVSREVPIDILEFLILSCGGNVISEAAMDQIENKK 400
Cdd:COG5163 313 LMVECRLVEEKLDTFEDNNKNK-DIMEMVSKPCSSLKSLFSGFKFYISREVPGDSLEFIILSCGGSVVGSPCEADIHVSE 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 401 DIDMsKVTHQIVDRPVLKNKVAGRTYIQPQWIFDCINKGELVPANKYLPGEALPPHLSPWGDAIGYDPTAPVEEGEEEES 480
Cdd:COG5163 392 KVDE-KVTHQIVDRPVMKNKVEGRTYIQPQWLFDSINKGKLACVENYCVGKRLPPHLSPFASVDSYDPRASLMTMEETQR 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 481 ESESESEDQVEEEDQEVVAGEEDDDDDEELQAQKELELEAQGIKYSETSEADKDVNKSKNKKRKVDEEEEEKKLKMIMMS 560
Cdd:COG5163 471 HSEEDLVNRFEDVRYEHVAGEEDDDDDEELQAQKELELEAQGIKYSETSEADKDVNKSKNKKRKVDEEEEEKKLKMIMMS 550
|
570 580 590 600
....*....|....*....|....*....|....*....|....*
gi 6321540 561 NKQKKLYKKMKYSNAKKEEQAENLKKKKKQIAKQkaklNKLDSKK 605
Cdd:COG5163 551 NKQKKLYKKMKYSNAKKEEQAENLKKKKKQIAKQ----KKLDSKK 591
|
|
| Pescadillo_N |
pfam06732 |
Pescadillo N-terminus; This family represents the N-terminal region of Pescadillo. Pescadillo ... |
7-266 |
8.86e-163 |
|
Pescadillo N-terminus; This family represents the N-terminal region of Pescadillo. Pescadillo protein localizes to distinct substructures of the interphase nucleus including nucleoli, the site of ribosome biogenesis. During mitosis pescadillo closely associates with the periphery of metaphase chromosomes and by late anaphase is associated with nucleolus-derived foci and prenucleolar bodies. Blastomeres in mouse embryos lacking pescadillo arrest at morula stages of development, the nucleoli fail to differentiate and accumulation of ribosomes is inhibited. It has been proposed that in mammalian cells pescadillo is essential for ribosome biogenesis and nucleologenesis and that disruption to its function results in cell cycle arrest. This family is often found in conjunction with a pfam00533 domain.
Pssm-ID: 461996 Cd Length: 269 Bit Score: 465.56 E-value: 8.86e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 7 NTRGNARNFITRSQAVRKLQVSLADFRRLCIFKGIYPREPRNKKKANKGSTAPTTFYYAKDIQYLMHEPVLAKFREHKTF 86
Cdd:pfam06732 1 GKSGAAKNYITRNQALKKLQLSLKDFRRLCILKGIYPREPKKKKKANKGSTAPKTYYYTKDIKYLLHEPILEKFREYKAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 87 ARKLTRALGRGEVSSAKRLEENRDSYTLDHIIKERYPSFPDAIRDIDDALNMLFLFSNLPSTNQVSSKIINDAQKICNQW 166
Cdd:pfam06732 81 AKKLKKALGKKEFERAKRLEKNKPKYKLDHIIKERYPTFIDALRDLDDALSMIFLFANLPSTDKIPANLIANCRRLTREF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 167 LAYVAKERLVRKVFVSIKGVYYQANIKGEEVRWLVPFKFPENIPSDVDFRIMLTFLEFYSTLLHFVLYKLYTDSGLIYPP 246
Cdd:pfam06732 161 QHYVIRSRSLRKVFVSIKGIYYQAEIKGQKITWLVPHKFTQRVPTDVDFRVMLTFLEFYETLLGFVNFKLYHSLNLKYPP 240
|
250 260
....*....|....*....|
gi 6321540 247 KLDLKKDKIISGLSSYILES 266
Cdd:pfam06732 241 KLDPRKDEKAAGLAALSLES 260
|
|
| BRCT_pescadillo_like |
cd17709 |
BRCT domain of pescadillo and related proteins; Pescadillo has been characterized in zebrafish ... |
359-447 |
1.92e-41 |
|
BRCT domain of pescadillo and related proteins; Pescadillo has been characterized in zebrafish as a protein involved in the control of cell proliferation, specifically in the developing embryo. Mammalian homologs have been linked to ribosome biogenesis and nucleologenesis, and yeast homologs have been shown to be required for synthesis of the 60S ribosomal subunit. Pescadillo contains a BRCT domain.
Pssm-ID: 349341 Cd Length: 86 Bit Score: 144.64 E-value: 1.92e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 359 LFSAFVFYVSREVPIDILEFLILSCGGNVISEAAMDQIEnkkDIDMSKVTHQIVDRPVLKNKVAGRTYIQPQWIFDCINK 438
Cdd:cd17709 1 LFKGLKFFLSREVPRESLEFIIRSFGGEVSWDGSDSPGA---DEDDESITHQIVDRPVQNKQYLSREYVQPQWVFDCVNA 77
|
....*....
gi 6321540 439 GELVPANKY 447
Cdd:cd17709 78 RILLPVEDY 86
|
|
| BRCT |
smart00292 |
breast cancer carboxy-terminal domain; |
359-436 |
5.63e-06 |
|
breast cancer carboxy-terminal domain;
Pssm-ID: 214602 [Multi-domain] Cd Length: 78 Bit Score: 44.67 E-value: 5.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 359 LFSAFVFYVSR---EVPIDILEFLILSCGGNVISeaamdqienkkDIDMSKVTHQIVDRP---VLKNKVA---GRTYIQP 429
Cdd:smart00292 3 LFKGKTFYITGsfdKEERDELKELIEALGGKVTS-----------SLSSKTTTHVIVGSPeggKLELLKAialGIPIVKE 71
|
....*..
gi 6321540 430 QWIFDCI 436
Cdd:smart00292 72 EWLLDCL 78
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| NOP7 |
COG5163 |
Protein required for biogenesis of the 60S ribosomal subunit [Translation, ribosomal structure ... |
1-605 |
0e+00 |
|
Protein required for biogenesis of the 60S ribosomal subunit [Translation, ribosomal structure and biogenesis];
Pssm-ID: 227492 [Multi-domain] Cd Length: 591 Bit Score: 803.91 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 1 MRIKKKNTRGNARNFITRSQAVRKLQVSLADFRRLCIFKGIYPREPRNKKKANKGSTAPTTFYYAKDIQYLMHEPVLAKF 80
Cdd:COG5163 1 MRIKGKNYIGPARKYITRGQAMKKLQLRLADFRRLCILKGVYPREPKNKKKANKGSTAPGTFYYIKDIQYLAHEPVYRKF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 81 REHKTFARKLTRALGRGEVSSAKRLEENRDSYTLDHIIKERYPSFPDAIRDIDDALNMLFLFSNLPSTNQVSSKIINDAQ 160
Cdd:COG5163 81 RENKRFARKLKRALGTGEFEYAKRLEICDEEYGLDHIIKERYPGFGDAVDDIDDALSMLFLFSMLPLTDRISSKIANDAQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 161 KICNQWLAYVAKERLVRKVFVSIKGVYYQANIKGEEVRWLVPFKFPENIPSDVDFRIMLTFLEFYSTLLHFVLYKLYTDS 240
Cdd:COG5163 161 EVCEMFEDYVRRRSLLRKSFMSIKGVYYQATIGGEKVVWFVPYKFPENIPGDVDFRIMLTFLEFYSTLLHFVSLKLYVEE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 241 GLIYPPKLDLKKDKIISGLSSYILEsrqEDSLLkldPTEIEEDVKVESLDASTLKSALNADEANTDetEKEEEQEKKQEK 320
Cdd:COG5163 241 GLDYPPKFDWSKPNFLDGLSSYELE---ESSSL---PTEIEEDVKVESLDSSTLKSAVCNDPGNID--VSKEELSEKIPE 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 321 EQEKEQNEETELDTFEDNNKNKgDILIQPSKYDSPVASLFSAFVFYVSREVPIDILEFLILSCGGNVISEAAMDQIENKK 400
Cdd:COG5163 313 LMVECRLVEEKLDTFEDNNKNK-DIMEMVSKPCSSLKSLFSGFKFYISREVPGDSLEFIILSCGGSVVGSPCEADIHVSE 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 401 DIDMsKVTHQIVDRPVLKNKVAGRTYIQPQWIFDCINKGELVPANKYLPGEALPPHLSPWGDAIGYDPTAPVEEGEEEES 480
Cdd:COG5163 392 KVDE-KVTHQIVDRPVMKNKVEGRTYIQPQWLFDSINKGKLACVENYCVGKRLPPHLSPFASVDSYDPRASLMTMEETQR 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 481 ESESESEDQVEEEDQEVVAGEEDDDDDEELQAQKELELEAQGIKYSETSEADKDVNKSKNKKRKVDEEEEEKKLKMIMMS 560
Cdd:COG5163 471 HSEEDLVNRFEDVRYEHVAGEEDDDDDEELQAQKELELEAQGIKYSETSEADKDVNKSKNKKRKVDEEEEEKKLKMIMMS 550
|
570 580 590 600
....*....|....*....|....*....|....*....|....*
gi 6321540 561 NKQKKLYKKMKYSNAKKEEQAENLKKKKKQIAKQkaklNKLDSKK 605
Cdd:COG5163 551 NKQKKLYKKMKYSNAKKEEQAENLKKKKKQIAKQ----KKLDSKK 591
|
|
| Pescadillo_N |
pfam06732 |
Pescadillo N-terminus; This family represents the N-terminal region of Pescadillo. Pescadillo ... |
7-266 |
8.86e-163 |
|
Pescadillo N-terminus; This family represents the N-terminal region of Pescadillo. Pescadillo protein localizes to distinct substructures of the interphase nucleus including nucleoli, the site of ribosome biogenesis. During mitosis pescadillo closely associates with the periphery of metaphase chromosomes and by late anaphase is associated with nucleolus-derived foci and prenucleolar bodies. Blastomeres in mouse embryos lacking pescadillo arrest at morula stages of development, the nucleoli fail to differentiate and accumulation of ribosomes is inhibited. It has been proposed that in mammalian cells pescadillo is essential for ribosome biogenesis and nucleologenesis and that disruption to its function results in cell cycle arrest. This family is often found in conjunction with a pfam00533 domain.
Pssm-ID: 461996 Cd Length: 269 Bit Score: 465.56 E-value: 8.86e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 7 NTRGNARNFITRSQAVRKLQVSLADFRRLCIFKGIYPREPRNKKKANKGSTAPTTFYYAKDIQYLMHEPVLAKFREHKTF 86
Cdd:pfam06732 1 GKSGAAKNYITRNQALKKLQLSLKDFRRLCILKGIYPREPKKKKKANKGSTAPKTYYYTKDIKYLLHEPILEKFREYKAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 87 ARKLTRALGRGEVSSAKRLEENRDSYTLDHIIKERYPSFPDAIRDIDDALNMLFLFSNLPSTNQVSSKIINDAQKICNQW 166
Cdd:pfam06732 81 AKKLKKALGKKEFERAKRLEKNKPKYKLDHIIKERYPTFIDALRDLDDALSMIFLFANLPSTDKIPANLIANCRRLTREF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 167 LAYVAKERLVRKVFVSIKGVYYQANIKGEEVRWLVPFKFPENIPSDVDFRIMLTFLEFYSTLLHFVLYKLYTDSGLIYPP 246
Cdd:pfam06732 161 QHYVIRSRSLRKVFVSIKGIYYQAEIKGQKITWLVPHKFTQRVPTDVDFRVMLTFLEFYETLLGFVNFKLYHSLNLKYPP 240
|
250 260
....*....|....*....|
gi 6321540 247 KLDLKKDKIISGLSSYILES 266
Cdd:pfam06732 241 KLDPRKDEKAAGLAALSLES 260
|
|
| BRCT_pescadillo_like |
cd17709 |
BRCT domain of pescadillo and related proteins; Pescadillo has been characterized in zebrafish ... |
359-447 |
1.92e-41 |
|
BRCT domain of pescadillo and related proteins; Pescadillo has been characterized in zebrafish as a protein involved in the control of cell proliferation, specifically in the developing embryo. Mammalian homologs have been linked to ribosome biogenesis and nucleologenesis, and yeast homologs have been shown to be required for synthesis of the 60S ribosomal subunit. Pescadillo contains a BRCT domain.
Pssm-ID: 349341 Cd Length: 86 Bit Score: 144.64 E-value: 1.92e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 359 LFSAFVFYVSREVPIDILEFLILSCGGNVISEAAMDQIEnkkDIDMSKVTHQIVDRPVLKNKVAGRTYIQPQWIFDCINK 438
Cdd:cd17709 1 LFKGLKFFLSREVPRESLEFIIRSFGGEVSWDGSDSPGA---DEDDESITHQIVDRPVQNKQYLSREYVQPQWVFDCVNA 77
|
....*....
gi 6321540 439 GELVPANKY 447
Cdd:cd17709 78 RILLPVEDY 86
|
|
| BRCT_2 |
pfam16589 |
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ... |
359-447 |
1.07e-08 |
|
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown.
Pssm-ID: 465186 [Multi-domain] Cd Length: 84 Bit Score: 52.37 E-value: 1.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 359 LFSAFVFYVSREVPIDILEF--LILSCGGNVIseaamDQIENKKDIDMSKVTHQIvdrpvLKNKVAGRTYIQPQWIFDCI 436
Cdd:pfam16589 4 LFEPLRFYINAIPSPSRSKLkrLIEANGGTVV-----DNINPAVYIVIAPYNKTD-----KLAENTKLGVVSPQWIFDCV 73
|
90
....*....|.
gi 6321540 437 NKGELVPANKY 447
Cdd:pfam16589 74 KKGKLLPLENY 84
|
|
| BRCT |
smart00292 |
breast cancer carboxy-terminal domain; |
359-436 |
5.63e-06 |
|
breast cancer carboxy-terminal domain;
Pssm-ID: 214602 [Multi-domain] Cd Length: 78 Bit Score: 44.67 E-value: 5.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 359 LFSAFVFYVSR---EVPIDILEFLILSCGGNVISeaamdqienkkDIDMSKVTHQIVDRP---VLKNKVA---GRTYIQP 429
Cdd:smart00292 3 LFKGKTFYITGsfdKEERDELKELIEALGGKVTS-----------SLSSKTTTHVIVGSPeggKLELLKAialGIPIVKE 71
|
....*..
gi 6321540 430 QWIFDCI 436
Cdd:smart00292 72 EWLLDCL 78
|
|
| BRCT_DNA_ligase_III |
cd18431 |
BRCT domain of DNA ligase 3 (LIG3) and similar proteins; LIG3 (EC 6.5.1.1), also termed DNA ... |
360-443 |
1.19e-03 |
|
BRCT domain of DNA ligase 3 (LIG3) and similar proteins; LIG3 (EC 6.5.1.1), also termed DNA ligase III, or polydeoxyribonucleotide synthase [ATP] 3, functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
Pssm-ID: 349384 [Multi-domain] Cd Length: 78 Bit Score: 38.06 E-value: 1.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 360 FSAFVFYVSREVPIDI--LEFLILSCGGNVISEaamdqienkkdIDMSKVTHQIVDRPVlKNKVAGRTYIQPQWIFDCIN 437
Cdd:cd18431 5 FTGVKVYLPGSVEDDYkkLKRYFIAYDGDVVEE-----------YDEEDATHVVVDRDD-KLGNPSAKVVSPEWLWDCIK 72
|
....*.
gi 6321540 438 KGELVP 443
Cdd:cd18431 73 KQKLVP 78
|
|
| BRCT_microcephalin_rpt3 |
cd17751 |
third BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage ... |
353-436 |
1.23e-03 |
|
third BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. It has been implicated in chromosome condensation and DNA damage induced cellular responses. It may play a role in neurogenesis and regulation of the size of the cerebral cortex. Microcephalin contains three BRCT repeats. This family corresponds to the third repeat.
Pssm-ID: 349382 Cd Length: 75 Bit Score: 37.98 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 353 DSPVASLFSAF-VFYVS--REVPIDILEFLILSCGGNVIseaamdqiENKKDIDMskvthqIVDRPVLKNkvaGRTYIQP 429
Cdd:cd17751 1 SRYRQNLFADGgPIYVSsnSVPPKDKLEELVLLCGGKVV--------KSSRKADI------CIGKTPPNP---DKPSVSE 63
|
....*..
gi 6321540 430 QWIFDCI 436
Cdd:cd17751 64 KWLLDSI 70
|
|
| BRCT_DNA_ligase_IV_rpt1 |
cd17722 |
first BRCT domain of DNA ligase 4 (LIG4) and similar proteins; LIG4 (EC 6.5.1.1), also termed ... |
359-443 |
1.53e-03 |
|
first BRCT domain of DNA ligase 4 (LIG4) and similar proteins; LIG4 (EC 6.5.1.1), also termed DNA ligase IV, or polydeoxyribonucleotide synthase [ATP] 4, is involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. It is a component of the LIG4-XRCC4 complex that is responsible for the NHEJ ligation step. LIG4 contains two BRCT domains. The family corresponds to the first one.
Pssm-ID: 349354 [Multi-domain] Cd Length: 90 Bit Score: 38.05 E-value: 1.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 359 LFSAFVFYV----SREVPIDILEFLILSCGGNVIseaamdQIENKKDidmskvTHQIVDRPV---LKN--KVAGRTYIQP 429
Cdd:cd17722 1 IFEGVEFCVmsdmSSPKSKAELEKLIKENGGKVV------QNPGAPD------TICVIAGREvvkVKNliKSGGHDVVKP 68
|
90
....*....|....
gi 6321540 430 QWIFDCINKGELVP 443
Cdd:cd17722 69 SWLLDCIARKELLP 82
|
|
| BRCT_Rev1 |
cd17719 |
BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha ... |
405-449 |
1.61e-03 |
|
BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha integrin-binding protein 80, or AIBP80, or Rev1-like terminal deoxycytidyl transferase, is a DNA template-dependent dCMP transferase required for mutagenesis induced by UV light.
Pssm-ID: 349351 [Multi-domain] Cd Length: 87 Bit Score: 37.93 E-value: 1.61e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 6321540 405 SKVTHQIVDR-PVLK-NKVAGRTYIQ---PQWIFDCINKGELVPANKYLP 449
Cdd:cd17719 38 SRVTHIIATNlPGSKiKKLKKARNYKvvrPEWIVDSIKAGRLLPEAPYLL 87
|
|
| BRCT |
pfam00533 |
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ... |
355-436 |
4.07e-03 |
|
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants.
Pssm-ID: 425736 [Multi-domain] Cd Length: 75 Bit Score: 36.50 E-value: 4.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321540 355 PVASLFSAFVFYVSR--EVPIDILEFLILSCGGNVISEAamdqienkkdidMSKVTHQIVDRPVLKNKVA---GRTYIQP 429
Cdd:pfam00533 1 PKEKLFSGKTFVITGldGLERDELKELIEKLGGKVTDSL------------SKKTTHVIVEARTKKYLKAkelGIPIVTE 68
|
....*..
gi 6321540 430 QWIFDCI 436
Cdd:pfam00533 69 EWLLDCI 75
|
|
| |
