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Conserved domains on  [gi|398365719|ref|NP_011623|]
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B-type cyclin CLB6 [Saccharomyces cerevisiae S288C]

Protein Classification

cyclin family protein( domain architecture ID 11472088)

cyclin family protein may associate with and activate its cognate cyclin-dependent kinase (CDK); similar to Saccharomyces cerevisiae S288C G1/S-specific cyclins and G2/mitotic-specific cyclins

CATH:  1.10.472.10
Gene Ontology:  GO:0000079|GO:0019901
PubMed:  30185601
SCOP:  4001102

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
1-380 4.79e-125

Cyclin [Cell division and chromosome partitioning];


:

Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 367.56  E-value: 4.79e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719   1 MNCIP-SPISERKIQINN--EDCIGK-----ENAFHTIPRES-SINLTPHSTNE----------KKVLSEVNSNK--IDS 59
Cdd:COG5024   30 ILQQPeMNILETRSAIVDflNQLSTVtrlsnGINFHSSKSTKlVVGTCLWLAKKtwgiissgesNERARIPRLSEcnLDS 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719  60 LQLPRGKL---QRDSTHLEKTRKRQ--LSNDSTDPIEPKTVK-----KIKCHQWKNLDSIEMDDPFMVAEYTDSIFSHLY 129
Cdd:COG5024  110 ILFIQMTLnedSYEPMIDYILKKDEnsLSPYELDENQLALDEkqaesKRESQSWQDLDATDQEDPLMVPEYASDIFEYLL 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 130 EKEIQMLPTHNYlMDTQSPYHLksSMRALLIDWLVEVHEKFHCLPETLFLAINLLDRFLSQNVVKLNKLQLLCITCLFIA 209
Cdd:COG5024  190 KLELIDLPNPNY-LIKQSLYEW--SMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIA 266
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 210 CKFEEVKLPKITNFAYVTDGAATVEGIRKAELFVLSSLGYNISLPNPLNFIRRISKADNYCIETRNMAKFIMEYSICCNK 289
Cdd:COG5024  267 SKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKASDYDIFSRTPAKFSSEISPVDYK 346
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 290 FIHLKPSYLAAMSMYIARKIKNENsKWDETFIHYSGGIDiesDPAFKDFISELVEDIAVPDTNLDSLRLKYKKPKHGMVY 369
Cdd:COG5024  347 FIQISPSWCAAAAMYLSRKILSQN-QWDRTLIHYSGNYT---NPDLKPLNESNKENLQNPSVHHDAIFPKYPSPTFGKAS 422
                        410
                 ....*....|.
gi 398365719 370 FKVFDWCKQKR 380
Cdd:COG5024  423 SPTGEWIRSNS 433
 
Name Accession Description Interval E-value
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
1-380 4.79e-125

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 367.56  E-value: 4.79e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719   1 MNCIP-SPISERKIQINN--EDCIGK-----ENAFHTIPRES-SINLTPHSTNE----------KKVLSEVNSNK--IDS 59
Cdd:COG5024   30 ILQQPeMNILETRSAIVDflNQLSTVtrlsnGINFHSSKSTKlVVGTCLWLAKKtwgiissgesNERARIPRLSEcnLDS 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719  60 LQLPRGKL---QRDSTHLEKTRKRQ--LSNDSTDPIEPKTVK-----KIKCHQWKNLDSIEMDDPFMVAEYTDSIFSHLY 129
Cdd:COG5024  110 ILFIQMTLnedSYEPMIDYILKKDEnsLSPYELDENQLALDEkqaesKRESQSWQDLDATDQEDPLMVPEYASDIFEYLL 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 130 EKEIQMLPTHNYlMDTQSPYHLksSMRALLIDWLVEVHEKFHCLPETLFLAINLLDRFLSQNVVKLNKLQLLCITCLFIA 209
Cdd:COG5024  190 KLELIDLPNPNY-LIKQSLYEW--SMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIA 266
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 210 CKFEEVKLPKITNFAYVTDGAATVEGIRKAELFVLSSLGYNISLPNPLNFIRRISKADNYCIETRNMAKFIMEYSICCNK 289
Cdd:COG5024  267 SKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKASDYDIFSRTPAKFSSEISPVDYK 346
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 290 FIHLKPSYLAAMSMYIARKIKNENsKWDETFIHYSGGIDiesDPAFKDFISELVEDIAVPDTNLDSLRLKYKKPKHGMVY 369
Cdd:COG5024  347 FIQISPSWCAAAAMYLSRKILSQN-QWDRTLIHYSGNYT---NPDLKPLNESNKENLQNPSVHHDAIFPKYPSPTFGKAS 422
                        410
                 ....*....|.
gi 398365719 370 FKVFDWCKQKR 380
Cdd:COG5024  423 SPTGEWIRSNS 433
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
113-249 2.19e-78

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 237.19  E-value: 2.19e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 113 DPFMVAEYTDSIFSHLYEKEIQMLPTHNYLMDtqsPYHLKSSMRALLIDWLVEVHEKFHCLPETLFLAINLLDRFLSQNV 192
Cdd:cd20568    1 DPLMVAEYVPEIFEYLRELELKTLPNPNYMDD---QKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRV 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 398365719 193 VKLNKLQLLCITCLFIACKFEEVKLPKITNFAYVTDGAATVEGIRKAELFVLSSLGY 249
Cdd:cd20568   78 VSLNKLQLVGISALFIASKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
124-252 1.68e-51

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 168.08  E-value: 1.68e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719  124 IFSHLYEKEIQMLPTHNYlMDTQSpyHLKSSMRALLIDWLVEVHEKFHCLPETLFLAINLLDRFLSQNVVKLNKLQLLCI 203
Cdd:pfam00134   2 IFQYLRELELKYLPKPDY-MDQQP--DINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGV 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 398365719  204 TCLFIACKFEEVKLPKITNFAYVTDGAATVEGIRKAELFVLSSLGYNIS 252
Cdd:pfam00134  79 TCLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
161-245 1.25e-19

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 82.26  E-value: 1.25e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719   161 DWLVEVHEKFHCLPETLFLAINLLDRFLSQNVVKLNKLQLLCITCLFIACKFEEVKLPKITNFAYVTDgaATVEGIRKAE 240
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78

                   ....*
gi 398365719   241 LFVLS 245
Cdd:smart00385  79 RLLLE 83
 
Name Accession Description Interval E-value
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
1-380 4.79e-125

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 367.56  E-value: 4.79e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719   1 MNCIP-SPISERKIQINN--EDCIGK-----ENAFHTIPRES-SINLTPHSTNE----------KKVLSEVNSNK--IDS 59
Cdd:COG5024   30 ILQQPeMNILETRSAIVDflNQLSTVtrlsnGINFHSSKSTKlVVGTCLWLAKKtwgiissgesNERARIPRLSEcnLDS 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719  60 LQLPRGKL---QRDSTHLEKTRKRQ--LSNDSTDPIEPKTVK-----KIKCHQWKNLDSIEMDDPFMVAEYTDSIFSHLY 129
Cdd:COG5024  110 ILFIQMTLnedSYEPMIDYILKKDEnsLSPYELDENQLALDEkqaesKRESQSWQDLDATDQEDPLMVPEYASDIFEYLL 189
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 130 EKEIQMLPTHNYlMDTQSPYHLksSMRALLIDWLVEVHEKFHCLPETLFLAINLLDRFLSQNVVKLNKLQLLCITCLFIA 209
Cdd:COG5024  190 KLELIDLPNPNY-LIKQSLYEW--SMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIA 266
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 210 CKFEEVKLPKITNFAYVTDGAATVEGIRKAELFVLSSLGYNISLPNPLNFIRRISKADNYCIETRNMAKFIMEYSICCNK 289
Cdd:COG5024  267 SKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKASDYDIFSRTPAKFSSEISPVDYK 346
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 290 FIHLKPSYLAAMSMYIARKIKNENsKWDETFIHYSGGIDiesDPAFKDFISELVEDIAVPDTNLDSLRLKYKKPKHGMVY 369
Cdd:COG5024  347 FIQISPSWCAAAAMYLSRKILSQN-QWDRTLIHYSGNYT---NPDLKPLNESNKENLQNPSVHHDAIFPKYPSPTFGKAS 422
                        410
                 ....*....|.
gi 398365719 370 FKVFDWCKQKR 380
Cdd:COG5024  423 SPTGEWIRSNS 433
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
113-249 2.19e-78

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 237.19  E-value: 2.19e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 113 DPFMVAEYTDSIFSHLYEKEIQMLPTHNYLMDtqsPYHLKSSMRALLIDWLVEVHEKFHCLPETLFLAINLLDRFLSQNV 192
Cdd:cd20568    1 DPLMVAEYVPEIFEYLRELELKTLPNPNYMDD---QKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRV 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 398365719 193 VKLNKLQLLCITCLFIACKFEEVKLPKITNFAYVTDGAATVEGIRKAELFVLSSLGY 249
Cdd:cd20568   78 VSLNKLQLVGISALFIASKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN_CLBs_yeast_rpt2 cd20512
second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae ...
255-375 2.13e-52

second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410216  Cd Length: 116  Bit Score: 170.10  E-value: 2.13e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 255 NPLNFIRRISKADNYCIETRNMAKFIMEYSICCNKFIHLKPSYLAAMSMYIARKIKNENsKWDETFIHYSGGIDIESDPA 334
Cdd:cd20512    1 NPMNFLRRISKADDYDIQTRTLAKYLLEITILDHRFLGYPPSLLAAAAMYLARKMLGRG-DWNDNLVHYSGYTESQLIPC 79
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 398365719 335 FKDFISELVEDIAvpdtNLDSLRLKYKKPKHGMVYFKVFDW 375
Cdd:cd20512   80 ADIMLEYLVKPIK----HHDAFFKKYSSKKFLKASIFVRDW 116
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
124-252 1.68e-51

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 168.08  E-value: 1.68e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719  124 IFSHLYEKEIQMLPTHNYlMDTQSpyHLKSSMRALLIDWLVEVHEKFHCLPETLFLAINLLDRFLSQNVVKLNKLQLLCI 203
Cdd:pfam00134   2 IFQYLRELELKYLPKPDY-MDQQP--DINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGV 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 398365719  204 TCLFIACKFEEVKLPKITNFAYVTDGAATVEGIRKAELFVLSSLGYNIS 252
Cdd:pfam00134  79 TCLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
117-249 7.72e-51

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 166.55  E-value: 7.72e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 117 VAEYTDSIFSHLYEKEIQMLPTHNYLMDTQspyHLKSSMRALLIDWLVEVHEKFHCLPETLFLAINLLDRFLSQNVVKLN 196
Cdd:cd20507    1 VSEYVKDIYKYLRQLEKKYAIDPDYLSGQP---EITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRK 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 398365719 197 KLQLLCITCLFIACKFEEVKLPKITNFAYVTDGAATVEGIRKAELFVLSSLGY 249
Cdd:cd20507   78 KLQLVGVTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLDF 130
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
119-249 8.99e-41

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 140.08  E-value: 8.99e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 119 EYTDSIFSHLYEKEIQMLPTHNYlMDTQSpyHLKSSMRALLIDWLVEVHEKFHCLPETLFLAINLLDRFLSQNVVKLNKL 198
Cdd:cd20504    1 EYADDIYEYLRESELKHRPKPDY-MRKQP--DINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKL 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 398365719 199 QLLCITCLFIACKFEEVKLPKITNFAYVTDGAATVEGIRKAELFVLSSLGY 249
Cdd:cd20504   78 QLVGTACMFIAAKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLSF 128
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
113-249 1.57e-37

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 132.15  E-value: 1.57e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 113 DPFMVAEYTDSIFSHLYEKEIQMLPTHNYLMDTQSpyHLKSSMRALLIDWLVEVHEKFHCLPETLFLAINLLDRFLSQNV 192
Cdd:cd20562    1 DPQMCSLYATDIYLNLRVAELKRRPLPDYMEKIQR--DITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNY 78
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 398365719 193 VKLNKLQLLCITCLFIACKFEEVKLPKITNFAYVTDGAATVEGIRKAELFVLSSLGY 249
Cdd:cd20562   79 VNRQRLQLLGVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQF 135
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
105-249 4.42e-36

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 128.62  E-value: 4.42e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 105 NLDSIEMDDPFMVAEYTDSIFSHLYEKEIQMLPTHNYlMDTQSPYHLKssMRALLIDWLVEVHEKFHCLPETLFLAINLL 184
Cdd:cd20567    6 DIDEVDKNNPLAAVEYVEDIYSFYRKVEPESCVPPYY-MSQQPDINEK--MRAILIDWLIEVHLKFELMPETLYLTVNLI 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 398365719 185 DRFLSQNVVKLNKLQLLCITCLFIACKFEEVKLPKITNFAYVTDGAATVEGIRKAELFVLSSLGY 249
Cdd:cd20567   83 DRFLSVKQVPRKELQLVGVTAMLIASKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
107-249 7.97e-36

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 127.76  E-value: 7.97e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 107 DSIEMDDPFMVAEYTDSIFSHLYEKEIQMLPThNYLMDTQspyHLKSSMRALLIDWLVEVHEKFHCLPETLFLAINLLDR 186
Cdd:cd20508    3 DEENSDDPFQVSEYAKDIFDYMKEREEKFVVP-DYLEKQT---ELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDL 78
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398365719 187 FLSQNVVKLNKLQLLCITCLFIACKFEEVKLPKITNFAYVTDGAATVEGIRKAELFVLSSLGY 249
Cdd:cd20508   79 YLSKKVVKKEKLQLLGATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDF 141
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
124-249 3.86e-33

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 120.11  E-value: 3.86e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 124 IFSHLYEKEIQMLPTHNYLmdTQSPyHLKSSMRALLIDWLVEVHEKFHCLPETLFLAINLLDRFLS-QNVVKLNKLQLLC 202
Cdd:cd20519    8 VWDLMLKKEELYKRDRDFL--NRHP-SLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLStQTNVPKTQLQLIG 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 398365719 203 ITCLFIACKFEEVKLPKITNFAYVTDGAATVEGIRKAELFVLSSLGY 249
Cdd:cd20519   85 ITCLFIAAKLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
113-249 5.73e-30

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 111.88  E-value: 5.73e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 113 DPFMVAEYTDSIFSHLYEKEIQMLPTHNYLmdtqSPYHLKSSMRALLIDWLVEVHEKFHCLPETLFLAINLLDRFLSQNV 192
Cdd:cd20566    1 NPQLCSDYVKDIYQYLRQLEVQQSIRPHYL----DGKEINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQP 76
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 398365719 193 VKLNKLQLLCITCLFIACKFEEVKLPKITNFAYVTDGAATVEGIRKAELFVLSSLGY 249
Cdd:cd20566   77 VSRKKLQLVGVTALLLASKYEEMYSPEIGDFVYITDNAYTKAQIREMEMLILKELNF 133
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
117-250 1.99e-29

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 110.53  E-value: 1.99e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 117 VAEYTDSIFSHLYEKEIQMLPTHNYLmdtQSPYHLKSSMRALLIDWLVEVHEKFHCLPETLFLAINLLDRFLSQNVVKLN 196
Cdd:cd20561    1 VPDYHEDIHTYLREMEVKCKPKVGYM---KKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRG 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 398365719 197 KLQLLCITCLFIACKFEEVKLPKITNFAYVTDGAATVEGIRKAELFVLSSLGYN 250
Cdd:cd20561   78 KLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFD 131
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
118-249 3.81e-29

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 109.58  E-value: 3.81e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 118 AEYTDSIFSHLYEKEIQMLPTHNYLMDTQspyhLKSSMRALLIDWLVEVHEKFHCLPETLFLAINLLDRFLSQNVVKLNK 197
Cdd:cd20565    2 SEYVKDIYAYLRQLEEEQAVRPKYLEGQE----VTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKM 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 398365719 198 LQLLCITCLFIACKFEEVKLPKITNFAYVTDGAATVEGIRKAELFVLSSLGY 249
Cdd:cd20565   78 LQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
155-247 1.05e-28

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 107.41  E-value: 1.05e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 155 MRALLIDWLVEVHEKFHCLPETLFLAINLLDRFLSQNVVKLNKLQLLCITCLFIACKFEEVKLPKITNFAYVTDGAATVE 234
Cdd:cd20536    1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTRE 80
                         90
                 ....*....|...
gi 398365719 235 GIRKAELFVLSSL 247
Cdd:cd20536   81 QICNLECIILTKL 93
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
156-251 1.81e-27

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 103.94  E-value: 1.81e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 156 RALLIDWLVEVHEKFHCLPETLFLAINLLDRFLSQNVVKLNKLQLLCITCLFIACKFEEVKLPKITNFAYVTDGAATVEG 235
Cdd:cd20542    1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKKQ 80
                         90
                 ....*....|....*.
gi 398365719 236 IRKAELFVLSSLGYNI 251
Cdd:cd20542   81 VLRMERRVLRRLRFDL 96
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
107-250 2.70e-27

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 105.69  E-value: 2.70e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 107 DSIEMDDPFMVAEYTDSIFSHLYEKEIQMLPTHNYlMDTQSpyHLKSSMRALLIDWLVEVHEKFHCLPETLFLAINLLDR 186
Cdd:cd20560   23 DSAADVDVLAVPEYAEDIHQYLREAELKHRPKPGY-MRKQP--DITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDR 99
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398365719 187 FLSQNVVKLNKLQLLCITCLFIACKFEEVKLPKITNFAYVTDGAATVEGIRKAELFVLSSLGYN 250
Cdd:cd20560  100 FLSCMSVLRGKLQLVGTAAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVLAFD 163
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
122-249 1.85e-25

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 99.95  E-value: 1.85e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 122 DSIFSHLYEKEIQMLPTHNYLmdtQSPYHLKSSMRALLIDWLVEVHEKFHCLPETLFLAINLLDRFLS--QNVVKlNKLQ 199
Cdd:cd20579   12 DEVWKNMLNKDKTYLRDKNFL---QKHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMAtqENVVK-TRLQ 87
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 398365719 200 LLCITCLFIACKFEEVKLPKITNFAYVTDGAATVEGIRKAELFVLSSLGY 249
Cdd:cd20579   88 LIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
254-372 2.43e-25

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 99.23  E-value: 2.43e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719  254 PNPLNFIRRISKADNY--CIETRNMAKFIMEYSICCNKFIHLKPSYLAAMSMYIARKIKNENSkWDETFIHYSgGIDIES 331
Cdd:pfam02984   1 PTPLSFLRRFSKAADYlhDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSPE-WTETLEHYT-GYSEED 78
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 398365719  332 dpaFKDFISELVEDIA-VPDTNLDSLRLKYKKPKHGMVYFKV 372
Cdd:pfam02984  79 ---LKPCVKLLLELLLnAPSSKLQAVRRKYSSSKFMKVSTLP 117
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
114-247 3.86e-24

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 96.45  E-value: 3.86e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 114 PFMVAEYTDSIFSHLYEKEIQMlpTHNYLMDTQSPyHLKSSMRALLIDWLVEVHEKFHCLPETLFLAINLLDRF-LSQNV 192
Cdd:cd20580    4 PELSWGNSKDVWLNMLKKESKY--VHDKHFLQLHP-ALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKN 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 398365719 193 VKLNKLQLLCITCLFIACKFEEVKLPKITNFAYVTDGAATVEGIRKAELFVLSSL 247
Cdd:cd20580   81 INKSMLQLIGITSLFIASKLEEIYPPKLHEFAYVTDGACSEDDILDMELIILKAL 135
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
161-245 1.25e-19

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 82.26  E-value: 1.25e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719   161 DWLVEVHEKFHCLPETLFLAINLLDRFLSQNVVKLNKLQLLCITCLFIACKFEEVKLPKITNFAYVTDgaATVEGIRKAE 240
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78

                   ....*
gi 398365719   241 LFVLS 245
Cdd:smart00385  79 RLLLE 83
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
122-250 2.22e-19

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 83.89  E-value: 2.22e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 122 DSIFSHLYEKEIQMLPTHNYLMDTQSpyHLKSSMRALLIDWLVEVHEKFHCLPETLFLAINLLDRFLSQNVVKLNKLQLL 201
Cdd:cd20515   24 DRVLQNLLSLEERYLPSASYFKCVQT--EIQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLSLVPIRKSQLQLL 101
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 398365719 202 CITCLFIACKFEEVKLPKITNFAYVTDGAATVEGIRKAELFVLSSLGYN 250
Cdd:cd20515  102 GAVCLFLASKLKETIPLTAEKLCIYTDNSITLQELLDWELLVLTKLKWD 150
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
153-229 8.56e-16

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 72.35  E-value: 8.56e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 398365719 153 SSMRALLIDWLVEVHEKFHCLPETLFLAINLLDRFLSQNVVKLNKLQLLCITCLFIACKFEEVKLPKITNFAYVTDG 229
Cdd:cd20521    1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDN 77
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
124-250 1.47e-15

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 73.10  E-value: 1.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 124 IFSHLYEKEIQMLPTHNYLMDTQSpyHLKSSMRALLIDWLVEVHEKFHCLPETLFLAINLLDRFLSQNVVKLNKLQLLCI 203
Cdd:cd20575   26 VLQNLLRLEERYVPRVSYFQCVQR--EIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVPTRKAQLQLLGA 103
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 398365719 204 TCLFIACKFEEVKLPKITNFAYVTDGAATVEGIRKAELFVLSSLGYN 250
Cdd:cd20575  104 VCMLLASKLRETTPLTIEKLCIYTDNSISPRQLLDWEILVLGKLKWD 150
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
258-330 3.16e-15

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 70.31  E-value: 3.16e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398365719   258 NFIRRISKADNYCIETRNMAKFIMEYSICCNKFIHLKPSYLAAMSMYIARKIKNENsKWDETFIHYSGGIDIE 330
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETP-PWTKELVHYTGYFTEE 72
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
121-250 1.04e-14

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 70.78  E-value: 1.04e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 121 TDSIFSHLYEKEIQMLPTHNYLMDTQSpyHLKSSMRALLIDWLVEVHEKFHCLPETLFLAINLLDRFLSQNVVKLNKLQL 200
Cdd:cd20573   22 NDRVLQTMLKAEETCLPSVSYFKCVQK--EILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQL 99
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 398365719 201 LCITCLFIACKFEEVKLPKITNFAYVTDGAATVEGIRKAELFVLSSLGYN 250
Cdd:cd20573  100 LGATCMFLASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLVLNKLKWD 149
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
254-325 2.59e-14

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410213  Cd Length: 111  Bit Score: 68.41  E-value: 2.59e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 398365719 254 PNPLNFIRRISKADNYCIETRNMAKFIMEYSICCNKFIHLKPSYLAAMSMYIARKIkNENSKWDETFIHYSG 325
Cdd:cd20509    1 PLPLHFLRRFSKAGGADAQKHTLAKYLMELTLLDYDMVHYKPSEIAAAALCLSRKI-LDEPEWTPTLEHYST 71
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
158-250 5.11e-14

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 67.02  E-value: 5.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 158 LLIDWLVEVHEKFHCLPETLFLAINLLDRFLSQNVVKLNKLQLLCITCLFIACKFEE--VKLPKITNFAYVTDGAATVEG 235
Cdd:cd20559    1 ALLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWEskARVPLLSELSKMCCNSYGEEL 80
                         90
                 ....*....|....*
gi 398365719 236 IRKAELFVLSSLGYN 250
Cdd:cd20559   81 FIQMEMHILNTLNWD 95
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
155-248 2.30e-13

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 65.70  E-value: 2.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 155 MRALLIDWLVEVHEKFHCLPETLFLAINLLDRFLSQNVVKLNKLQLLCITCLFIACKFEEV--KLPKITNF-AYVTDGAA 231
Cdd:cd20528    6 LRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELddNIPKISDLnRYLCNSVY 85
                         90
                 ....*....|....*..
gi 398365719 232 TVEGIRKAELFVLSSLG 248
Cdd:cd20528   86 SKQEYLQMELLILEFFQ 102
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
159-241 2.92e-13

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 64.74  E-value: 2.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 159 LIDWLVEVHEKFHCLPETLFLAINLLDRFLSQNVVKLNKLQLLCITCLFIACKFEEVKlPKITNFAYVTDGaaTVEGIRK 238
Cdd:cd00043    2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELP-RTLKEIAKVSGV--SEKELRK 78

                 ...
gi 398365719 239 AEL 241
Cdd:cd00043   79 AEK 81
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
113-250 8.03e-13

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 65.40  E-value: 8.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 113 DPFMVaeYTDSIFSHLYEKEIQMLPTHNYLMDTQSpyHLKSSMRALLIDWLVEVHEKFHCLPETLFLAINLLDRFLSQNV 192
Cdd:cd20574   17 DPNLL--YDDRVLQNLLTIEERYLPQCSYFKCVQK--DIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAVVP 92
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 398365719 193 VKLNKLQLLCITCLFIACKFEEVKLPKITNFAYVTDGAATVEGIRKAELFVLSSLGYN 250
Cdd:cd20574   93 TRKCHLQLLGAVCMFLASKLKETIPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKWN 150
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
160-251 1.27e-12

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 63.48  E-value: 1.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 160 IDWLVEVHEKFHCLPETLFLAINLLDRFLSQNVVKLNKLQLLCITCLFIACKF--EEVKLPKITNFAYVTDGAATVEGIR 237
Cdd:cd20526    6 VRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTneEDEVIPSTKDLVRVSKCGCSVAEVL 85
                         90
                 ....*....|....
gi 398365719 238 KAELFVLSSLGYNI 251
Cdd:cd20526   86 RMERIILDKLHWDL 99
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
254-344 5.41e-12

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 61.56  E-value: 5.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 254 PNPLNFIRRISKADNYCIETRNMAKFIMEYSICCNKFIHLKPSYLAAMSMYIARKIKNENSKWDETFIHYSGgidiESDP 333
Cdd:cd20537    1 PTPLSFLRRYLSLLGLDEKVRHLARYLLELSLLDYEFLKYRPSLIAAAALYLARKILGEPPPSPQLLQLVTG----YSEN 76
                         90
                 ....*....|.
gi 398365719 334 AFKDFISELVE 344
Cdd:cd20537   77 DLQECAKELLE 87
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
160-249 3.69e-11

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 59.25  E-value: 3.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 160 IDWLVEVHEKFHCLPETLFLAINLLDRFLSQNVVKLNK---LQLLCITCLFIACKFEEVKLPKITNFA-----YVTDgAA 231
Cdd:cd20543    6 IDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPKDKpwmLQLLAVACLSLAAKMEETDVPLLVDLQveepkYVFE-AK 84
                         90
                 ....*....|....*...
gi 398365719 232 TvegIRKAELFVLSSLGY 249
Cdd:cd20543   85 T---IQRMELLVLSTLEW 99
CYCLIN_CCNB3_rpt2 cd20510
second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 ...
254-372 4.13e-11

second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410214  Cd Length: 115  Bit Score: 59.60  E-value: 4.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 254 PNPLNFIRRISKADNYCIETRNMAKFIMEYSICCNKFIHLKPSYLAAMSMYIARKIKNENSkWDETFIHYSGGIDIEsdp 333
Cdd:cd20510    1 PLSYRFLRRYAKCARASMETLTLARYILELSLMEYQFVQERASKLAAAALLLALKMKNLGE-WTPTLEYYSGYSAED--- 76
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 398365719 334 afkdfISELVEDI-----AVPDTNLDSLRLKYKKPkhgmVYFKV 372
Cdd:cd20510   77 -----LLPLVRKLnamltKPPNKKLKTVRSKYSHK----VFFEV 111
CYCLIN_CCNB2_rpt2 cd20570
second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 ...
254-325 1.56e-08

second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410273  Cd Length: 119  Bit Score: 52.58  E-value: 1.56e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 398365719 254 PNPLNFIRRISKADNYCIETRNMAKFIMEYSICCNKFIHLKPSYLAAMSMYIARKIKNEnSKWDETFIHYSG 325
Cdd:cd20570    1 PLPLHFLRRASKAGSADVEKHTLAKYLMELTLIDYDMVHYHPSEIAAAALCLSQKVLDG-GKWSLTQQYYTG 71
CYCLIN_CCNB1_rpt2 cd20569
second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 ...
254-325 2.02e-08

second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410272  Cd Length: 121  Bit Score: 52.20  E-value: 2.02e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 398365719 254 PNPLNFIRRISKADNYCIETRNMAKFIMEYSICCNKFIHLKPSYLAAMSMYIARKIKNeNSKWDETFIHYSG 325
Cdd:cd20569    1 PLPLHFLRRASKIGEVDVEQHTLAKYLMELTMVDYDMVHFPPSQIAAAAFCLALKILD-NGEWTPTLQHYMS 71
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
151-249 4.02e-06

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 44.86  E-value: 4.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 151 LKSSMRALLIDWLVEVHEKFHCLPETLFLAINLLDRFLSQNVVKLNKLQLLCITCLFIACKFEEVKLPKITNFAYVTDGA 230
Cdd:cd20517    1 VTSDNRKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQGTKETLQKTGAACLLIASKIRTVKPITVSKLTYLSCDC 80
                         90
                 ....*....|....*....
gi 398365719 231 ATVEGIRKAELFVLSSLGY 249
Cdd:cd20517   81 FTNLELINQEKDILEALKW 99
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
255-325 4.35e-06

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 44.32  E-value: 4.35e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 398365719 255 NPLNFIRRISKADNYCIETRNMAKFIMEYSICCNKFIHLKPSYLAAMSMYIARKIkNENSKWDETFIHYSG 325
Cdd:cd00043    1 KAVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKL-EELPRTLKEIAKVSG 70
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
174-247 5.66e-06

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 44.27  E-value: 5.66e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 398365719 174 PETLFLAINLLDRFLSqnVVKLNKLQLLCIT--CLFIACKF--EEVKLPKITNFAYVTDGAATVEGIRKAELFVLSSL 247
Cdd:cd20523   19 PETFALAVNLLDRFLS--KVKVKPKHLACITvsCFHIAIKSveEDQNIPSAEDLIRISQCGCTAADLMRMEGIILEKL 94
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
259-365 2.73e-05

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 43.01  E-value: 2.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 259 FIRRISKADNYC---IETRNMAKFIMEYSICCNKFIHLKPSYLAAMSMYIARKIKNENSkWDETFIHYSGgidiesdPAF 335
Cdd:cd20506    6 FLRRFLRAAQASvpdLKLEFLANYLAELSLLDYEFLKYLPSLIAASAVFLARHTLNPHP-WNPTLEHYTG-------YKA 77
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 398365719 336 KDFiSELVEDI-----AVPDTNLDSLRLKYKKPKH 365
Cdd:cd20506   78 ADL-KPCVQALhdlqlNASGSSLQAVREKYKQHKF 111
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
254-325 3.67e-05

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 42.68  E-value: 3.67e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 398365719 254 PNPLNFIRRISKADNYCIETRNMAKFIMEYSICCNKFIHLKPSYLAAMSMYIARKIKNENSKWDETFIHYSG 325
Cdd:cd20511    1 PTPYVFLVRFLKAAQSDKKLENLAFFLVELGLVEYEMLKYSPSMLAASAVYTARCTLNKTPEWTSTLEFHTG 72
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
175-249 1.54e-04

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 40.58  E-value: 1.54e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 398365719 175 ETLFLAINLLDRFLSQNVVKLNKLQLLCITCLFIACKF--EEVKLPKITNFAYVTDGAATVEGIRKAELFVLSSLGY 249
Cdd:cd20583   21 ETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAieEERNVPLATDLIRISQYRFTVSDMMRMEKIILEKLCW 97
CYCLIN_CCNG2 cd20584
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ...
170-240 2.08e-04

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410287  Cd Length: 96  Bit Score: 40.22  E-value: 2.08e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398365719 170 FHCLPETLFLAINLLDRFLSQNVVKLNKLQLLCITCLFIACKF--EEVKLPKITNFAYVTDGAATVEGIRKAE 240
Cdd:cd20584   16 FGFSTETFVLAVNILDRFLALMKVKPKHLSCIGICCFHLAARVveEECNIPSSHDLIRISQCKCTVSDLKRME 88
CYCLIN_CCNM_CCNQ_rpt1 cd20534
first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
163-250 2.24e-03

first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410237 [Multi-domain]  Cd Length: 110  Bit Score: 37.53  E-value: 2.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 163 LVEVHEKFHCLPETLFLAINLLDRFLSQNVVKLNKLQLLCITCLFIACKFEE--VKLPKITNFAYVT---DGAAT----- 232
Cdd:cd20534    9 IREAGLKLELSSVTIATACVLYHRFYRELSLEDYDPYLVAMACLYLAGKAEEqpRRLRDIINVSYRIlhpDKPPLeldde 88
                         90       100
                 ....*....|....*....|..
gi 398365719 233 ----VEGIRKAELFVLSSLGYN 250
Cdd:cd20534   89 ywelRDSIVNCELLLLRILKFD 110
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
163-251 2.52e-03

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 37.96  E-value: 2.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365719 163 LVEVHEKFHcLPETLF-LAINLLDRF-LSQNVVKLNKLQLLcITCLFIACKFEEVKLPkITNFAYVTDGAA-TVEGIRKA 239
Cdd:cd20524   62 LLEFCRAFK-LPDSVLaTALTYFKRFyLKNSVMEYHPKEIM-LTCLYLACKVEEFNIS-IDQFVGNIKESEkTAEIILEY 138
                         90
                 ....*....|..
gi 398365719 240 ELFVLSSLGYNI 251
Cdd:cd20524  139 ELLLLQGLNFHL 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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