Ndc10 component of the yeast centromere-binding factor 3; Ndc10 is a multidomain protein ...
29-506
0e+00
Ndc10 component of the yeast centromere-binding factor 3; Ndc10 is a multidomain protein conserved in Saccharomycotina that interacts with kinetochore components. This model characterizes the majority of the protein; some family members may have an additional C-terminal domain that is homologous to transcriptional activators (GCR1_C). Ndc10 is part of the centromere-binding factor 3 (CBF3) complex in budding yeast. The CBF3 complex contains four essential proteins, Ndc10, Cep3, Ctf13, and Skp1. CBF3/Ndc10 is essential for the recruitment of the centromeric nucleosome and formation of the kinetochore. The Kinetochore is the large, multiprotein assembly that serves to connect condensed sister chromatids to the mitotic spindle. Ndc10 forms a dimer and it has non-sequence-specific DNA binding activity via the DNA backbone. Ndc10 also plays an important role in the coordination of cell division. It has been noted that the protein bears resemblance to the tyrosine recombinases (type IB topoisomerase/lambda-integrase).
:
Pssm-ID: 211427 Cd Length: 413 Bit Score: 579.34 E-value: 0e+00
Transcriptional activator of glycolytic enzymes; This domain family is found in eukaryotes, ...
843-922
3.43e-20
Transcriptional activator of glycolytic enzymes; This domain family is found in eukaryotes, and is approximately 80 amino acids in length. This family is activates the transcription of glycolytic enzymes.
:
Pssm-ID: 432628 Cd Length: 80 Bit Score: 85.66 E-value: 3.43e-20
Ndc10 component of the yeast centromere-binding factor 3; Ndc10 is a multidomain protein ...
29-506
0e+00
Ndc10 component of the yeast centromere-binding factor 3; Ndc10 is a multidomain protein conserved in Saccharomycotina that interacts with kinetochore components. This model characterizes the majority of the protein; some family members may have an additional C-terminal domain that is homologous to transcriptional activators (GCR1_C). Ndc10 is part of the centromere-binding factor 3 (CBF3) complex in budding yeast. The CBF3 complex contains four essential proteins, Ndc10, Cep3, Ctf13, and Skp1. CBF3/Ndc10 is essential for the recruitment of the centromeric nucleosome and formation of the kinetochore. The Kinetochore is the large, multiprotein assembly that serves to connect condensed sister chromatids to the mitotic spindle. Ndc10 forms a dimer and it has non-sequence-specific DNA binding activity via the DNA backbone. Ndc10 also plays an important role in the coordination of cell division. It has been noted that the protein bears resemblance to the tyrosine recombinases (type IB topoisomerase/lambda-integrase).
Pssm-ID: 211427 Cd Length: 413 Bit Score: 579.34 E-value: 0e+00
Centromere DNA-binding protein complex CBF3 subunit, domain 2; NDC10_II is a the second of ...
186-495
4.58e-148
Centromere DNA-binding protein complex CBF3 subunit, domain 2; NDC10_II is a the second of five domains on the Kluyveromyces lactis Ndc10 protein. Each subunit of the Ndc10 dimer binds a separate fragment of DNA, suggesting that Ndc10 stabilizes a DNA loop at the centromere.
Pssm-ID: 407051 Cd Length: 313 Bit Score: 441.04 E-value: 4.58e-148
Transcriptional activator of glycolytic enzymes; This domain family is found in eukaryotes, ...
843-922
3.43e-20
Transcriptional activator of glycolytic enzymes; This domain family is found in eukaryotes, and is approximately 80 amino acids in length. This family is activates the transcription of glycolytic enzymes.
Pssm-ID: 432628 Cd Length: 80 Bit Score: 85.66 E-value: 3.43e-20
Ndc10 component of the yeast centromere-binding factor 3; Ndc10 is a multidomain protein ...
29-506
0e+00
Ndc10 component of the yeast centromere-binding factor 3; Ndc10 is a multidomain protein conserved in Saccharomycotina that interacts with kinetochore components. This model characterizes the majority of the protein; some family members may have an additional C-terminal domain that is homologous to transcriptional activators (GCR1_C). Ndc10 is part of the centromere-binding factor 3 (CBF3) complex in budding yeast. The CBF3 complex contains four essential proteins, Ndc10, Cep3, Ctf13, and Skp1. CBF3/Ndc10 is essential for the recruitment of the centromeric nucleosome and formation of the kinetochore. The Kinetochore is the large, multiprotein assembly that serves to connect condensed sister chromatids to the mitotic spindle. Ndc10 forms a dimer and it has non-sequence-specific DNA binding activity via the DNA backbone. Ndc10 also plays an important role in the coordination of cell division. It has been noted that the protein bears resemblance to the tyrosine recombinases (type IB topoisomerase/lambda-integrase).
Pssm-ID: 211427 Cd Length: 413 Bit Score: 579.34 E-value: 0e+00
Centromere DNA-binding protein complex CBF3 subunit, domain 2; NDC10_II is a the second of ...
186-495
4.58e-148
Centromere DNA-binding protein complex CBF3 subunit, domain 2; NDC10_II is a the second of five domains on the Kluyveromyces lactis Ndc10 protein. Each subunit of the Ndc10 dimer binds a separate fragment of DNA, suggesting that Ndc10 stabilizes a DNA loop at the centromere.
Pssm-ID: 407051 Cd Length: 313 Bit Score: 441.04 E-value: 4.58e-148
Transcriptional activator of glycolytic enzymes; This domain family is found in eukaryotes, ...
843-922
3.43e-20
Transcriptional activator of glycolytic enzymes; This domain family is found in eukaryotes, and is approximately 80 amino acids in length. This family is activates the transcription of glycolytic enzymes.
Pssm-ID: 432628 Cd Length: 80 Bit Score: 85.66 E-value: 3.43e-20
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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of your query sequence and the protein sequences used to curate the domain model,
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The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
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Domains are color coded according to superfamilies
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the
advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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