NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|398365889|ref|NP_011662|]
View 

Ecl1p [Saccharomyces cerevisiae S288C]

Protein Classification

Ecl1 domain-containing protein( domain architecture ID 10583288)

Ecl1 domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Ecl1 pfam12855
ECL1/2/3 zinc binding proteins; This family is involved in the chronological life-span of S. ...
 5-92 5.79e-04

ECL1/2/3 zinc binding proteins; This family is involved in the chronological life-span of S. cerevisiae. Over-expression leads to an extended viability of wild-type strains, indicating a role in regulation. There are four cysteine residues conserved in the N-terminal region involved in zinc binding and have been shown to be essential for protein functions. Ecl1-family proteins are essential for sexual development caused by zinc depletion in S. pombe. They are also important for cellular response to zinc limitation.


:

Pssm-ID: 432834 [Multi-domain]  Cd Length: 172  Bit Score: 39.01  E-value: 5.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365889    5 FNDYCTVCDRLIPTSPqktnintrkiqrdnetksslqSNKLYCSEDCKLKDSNPLNekllshlhkKSKTSHSHNLTPPLS 84
Cdd:pfam12855   4 FLQFCATCEKQIIVPD---------------------NSSLYCSESCRRKDSEKSS---------SSSSSSSSPPLSPFY 53


                  ....*...
gi 398365889   85 YSKNLTAS 92
Cdd:pfam12855  54 SSWPSEPR 61
 
Name Accession Description Interval E-value
Ecl1 pfam12855
ECL1/2/3 zinc binding proteins; This family is involved in the chronological life-span of S. ...
 5-92 5.79e-04

ECL1/2/3 zinc binding proteins; This family is involved in the chronological life-span of S. cerevisiae. Over-expression leads to an extended viability of wild-type strains, indicating a role in regulation. There are four cysteine residues conserved in the N-terminal region involved in zinc binding and have been shown to be essential for protein functions. Ecl1-family proteins are essential for sexual development caused by zinc depletion in S. pombe. They are also important for cellular response to zinc limitation.


Pssm-ID: 432834 [Multi-domain]  Cd Length: 172  Bit Score: 39.01  E-value: 5.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365889    5 FNDYCTVCDRLIPTSPqktnintrkiqrdnetksslqSNKLYCSEDCKLKDSNPLNekllshlhkKSKTSHSHNLTPPLS 84
Cdd:pfam12855   4 FLQFCATCEKQIIVPD---------------------NSSLYCSESCRRKDSEKSS---------SSSSSSSSPPLSPFY 53


                  ....*...
gi 398365889   85 YSKNLTAS 92
Cdd:pfam12855  54 SSWPSEPR 61
 
Name Accession Description Interval E-value
Ecl1 pfam12855
ECL1/2/3 zinc binding proteins; This family is involved in the chronological life-span of S. ...
 5-92 5.79e-04

ECL1/2/3 zinc binding proteins; This family is involved in the chronological life-span of S. cerevisiae. Over-expression leads to an extended viability of wild-type strains, indicating a role in regulation. There are four cysteine residues conserved in the N-terminal region involved in zinc binding and have been shown to be essential for protein functions. Ecl1-family proteins are essential for sexual development caused by zinc depletion in S. pombe. They are also important for cellular response to zinc limitation.


Pssm-ID: 432834 [Multi-domain]  Cd Length: 172  Bit Score: 39.01  E-value: 5.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365889    5 FNDYCTVCDRLIPTSPqktnintrkiqrdnetksslqSNKLYCSEDCKLKDSNPLNekllshlhkKSKTSHSHNLTPPLS 84
Cdd:pfam12855   4 FLQFCATCEKQIIVPD---------------------NSSLYCSESCRRKDSEKSS---------SSSSSSSSPPLSPFY 53


                  ....*...
gi 398365889   85 YSKNLTAS 92
Cdd:pfam12855  54 SSWPSEPR 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH