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Conserved domains on  [gi|398366117|ref|NP_011716|]
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Elongator subunit ELP2 [Saccharomyces cerevisiae S288C]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11525814)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 52-413 2.81e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.87  E-value: 2.81e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117  52 YATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWkftDYSHLQCIQTIQ-HYS--KTIVALSALPSLISVGCaDGTISI 128
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW---DLETGELLRTLKgHTGpvRDVAASADGTYLASGSS-DKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 129 WrqNIQNDEfgLAHEFTikkGFF-YPLCLSLSKveeKKYLLAIGGTNVNVFIASfilsdsgIEKCRVVAELEGHEDWVKS 207
Cdd:cd00200   78 W--DLETGE--CVRTLT---GHTsYVSSVAFSP---DGRILSSSSRDKTIKVWD-------VETGKCLTTLRGHTDWVNS 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 208 LAFrhqeTPGDYLLCSGSQDRYIRLWRIRINDLIddseedskkltllsnkqykfqiddelrvginfeALIMGHDDWISSL 287
Cdd:cd00200  141 VAF----SPDGTFVASSSQDGTIKLWDLRTGKCV---------------------------------ATLTGHTGEVNSV 183

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 288 QWHESRLQLLAATADTSLMVWEPDetSGIWVCSLRlgemsskgastatGSSGGFWSCLWFTHERMdFF--LTNGKTGSWR 365
Cdd:cd00200  184 AFSPDGEKLLSSSSDGTIKLWDLS--TGKCLGTLR-------------GHENGVNSVAFSPDGYL-LAsgSEDGTIRVWD 247

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 398366117 366 MWATKdniiCDQRLgiSGATKDVTDIAWSPSGEYLLATSLDQTTRLFA 413
Cdd:cd00200  248 LRTGE----CVQTL--SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
274-733 8.62e-21

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.36  E-value: 8.62e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 274 EALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWvcslrlgemsskgasTATGSSGGFWSCLWFTHERMd 353
Cdd:COG2319   29 LLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLA---------------TLLGHTAAVLSVAFSPDGRL- 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 354 fFLTNGKTGSWRMWATKDNIIcdqRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLfapwiYDASGRKrEIATWHEfs 433
Cdd:COG2319   93 -LASASADGTVRLWDLATGLL---LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL-----WDLATGK-LLRTLTG-- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 434 rpqiHGYDMICVETVTD-TRFVSGGDEKILRSFDLPKGvaGMLQKFVG-------IQFeekSemPDSATVPVLGLSNKAG 505
Cdd:COG2319  161 ----HSGAVTSVAFSPDgKLLASGSDDGTVRLWDLATG--KLLRTLTGhtgavrsVAF---S--PDGKLLASGSADGTVR 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 506 eddaneddeeeeggnketpditdplsllecppmedqlqrhlLW-----PEVEKLYGHGFEITCLDISPDQKLIASACRSN 580
Cdd:COG2319  230 -----------------------------------------LWdlatgKLLRTLTGHSGSVRSVAFSPDGRLLASGSADG 268

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 581 nvqnaVIRIFSTENWLEIKPaLPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELrfkneKPHTRIIWDAD 660
Cdd:COG2319  269 -----TVRLWDLATGELLRT-LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-----TGHTGAVRSVA 337

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398366117 661 WAPLefGNVFVTASRDKTVKVWrhqkEPADDYVLEASIKHTKAVTAISIHDSmirEKILISVGlENGEIYLYS 733
Cdd:COG2319  338 FSPD--GKTLASGSDDGTVRLW----DLATGELLRTLTGHTGAVTSVAFSPD---GRTLASGS-ADGTVRLWD 400
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 52-413 2.81e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.87  E-value: 2.81e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117  52 YATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWkftDYSHLQCIQTIQ-HYS--KTIVALSALPSLISVGCaDGTISI 128
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW---DLETGELLRTLKgHTGpvRDVAASADGTYLASGSS-DKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 129 WrqNIQNDEfgLAHEFTikkGFF-YPLCLSLSKveeKKYLLAIGGTNVNVFIASfilsdsgIEKCRVVAELEGHEDWVKS 207
Cdd:cd00200   78 W--DLETGE--CVRTLT---GHTsYVSSVAFSP---DGRILSSSSRDKTIKVWD-------VETGKCLTTLRGHTDWVNS 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 208 LAFrhqeTPGDYLLCSGSQDRYIRLWRIRINDLIddseedskkltllsnkqykfqiddelrvginfeALIMGHDDWISSL 287
Cdd:cd00200  141 VAF----SPDGTFVASSSQDGTIKLWDLRTGKCV---------------------------------ATLTGHTGEVNSV 183

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 288 QWHESRLQLLAATADTSLMVWEPDetSGIWVCSLRlgemsskgastatGSSGGFWSCLWFTHERMdFF--LTNGKTGSWR 365
Cdd:cd00200  184 AFSPDGEKLLSSSSDGTIKLWDLS--TGKCLGTLR-------------GHENGVNSVAFSPDGYL-LAsgSEDGTIRVWD 247

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 398366117 366 MWATKdniiCDQRLgiSGATKDVTDIAWSPSGEYLLATSLDQTTRLFA 413
Cdd:cd00200  248 LRTGE----CVQTL--SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
27-411 9.43e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 119.63  E-value: 9.43e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117  27 KKIVAFGAGKTIALWDPiepNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWkftDYSHLQCIQTIQHYSKT 106
Cdd:COG2319   91 RLLASASADGTVRLWDL---ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW---DLATGKLLRTLTGHSGA 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 107 IVALSALP--SLISVGCADGTISIWrqNIQNDEfgLAHEFTIKKGFFYPLCLSL-SKveekkyLLAIGGtnvnvfiasfi 183
Cdd:COG2319  165 VTSVAFSPdgKLLASGSDDGTVRLW--DLATGK--LLRTLTGHTGAVRSVAFSPdGK------LLASGS----------- 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 184 lSDSGI-----EKCRVVAELEGHEDWVKSLAFrhqeTPGDYLLCSGSQDRYIRLWRIrindliddseEDSKKLTLLSnkq 258
Cdd:COG2319  224 -ADGTVrlwdlATGKLLRTLTGHSGSVRSVAF----SPDGRLLASGSADGTVRLWDL----------ATGELLRTLT--- 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 259 ykfqiddelrvginfealimGHDDWISSLQWHESRLQLLAATADTSLMVWEPD--------ETSGIWVCSLRLgemSSKG 330
Cdd:COG2319  286 --------------------GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtgkllrtlTGHTGAVRSVAF---SPDG 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 331 ASTATGSSGgfwsclwfthermdffltngktGSWRMWATKDNiICDQRLgiSGATKDVTDIAWSPSGEYLLATSLDQTTR 410
Cdd:COG2319  343 KTLASGSDD----------------------GTVRLWDLATG-ELLRTL--TGHTGAVTSVAFSPDGRTLASGSADGTVR 397


                 .
gi 398366117 411 L 411
Cdd:COG2319  398 L 398
WD40 COG2319
WD40 repeat [General function prediction only];
274-733 8.62e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.36  E-value: 8.62e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 274 EALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWvcslrlgemsskgasTATGSSGGFWSCLWFTHERMd 353
Cdd:COG2319   29 LLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLA---------------TLLGHTAAVLSVAFSPDGRL- 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 354 fFLTNGKTGSWRMWATKDNIIcdqRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLfapwiYDASGRKrEIATWHEfs 433
Cdd:COG2319   93 -LASASADGTVRLWDLATGLL---LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL-----WDLATGK-LLRTLTG-- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 434 rpqiHGYDMICVETVTD-TRFVSGGDEKILRSFDLPKGvaGMLQKFVG-------IQFeekSemPDSATVPVLGLSNKAG 505
Cdd:COG2319  161 ----HSGAVTSVAFSPDgKLLASGSDDGTVRLWDLATG--KLLRTLTGhtgavrsVAF---S--PDGKLLASGSADGTVR 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 506 eddaneddeeeeggnketpditdplsllecppmedqlqrhlLW-----PEVEKLYGHGFEITCLDISPDQKLIASACRSN 580
Cdd:COG2319  230 -----------------------------------------LWdlatgKLLRTLTGHSGSVRSVAFSPDGRLLASGSADG 268

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 581 nvqnaVIRIFSTENWLEIKPaLPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELrfkneKPHTRIIWDAD 660
Cdd:COG2319  269 -----TVRLWDLATGELLRT-LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-----TGHTGAVRSVA 337

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398366117 661 WAPLefGNVFVTASRDKTVKVWrhqkEPADDYVLEASIKHTKAVTAISIHDSmirEKILISVGlENGEIYLYS 733
Cdd:COG2319  338 FSPD--GKTLASGSDDGTVRLW----DLATGELLRTLTGHTGAVTSVAFSPD---GRTLASGS-ADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 554-786 2.83e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.85  E-value: 2.83e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 554 LYGHGFEITCLDISPDQKLIASACRSNnvqnaVIRIFSTENWLEIKpALPFHSLTITRLKFSKDGKFLLSVCRDRKWALW 633
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDG-----TIKVWDLETGELLR-TLKGHTGPVRDVAASADGTYLASGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 634 ERNMEDNTFELrfkneKPHTRIIWDADWAPLefGNVFVTASRDKTVKVWrhqkePADDYVLEASIK-HTKAVTAISIHDS 712
Cdd:cd00200   79 DLETGECVRTL-----TGHTSYVSSVAFSPD--GRILSSSSRDKTIKVW-----DVETGKCLTTLRgHTDWVNSVAFSPD 146

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398366117 713 mireKILISVGLENGEIYLYSytLGKFELITQLNediTPADKITRLRWSHlkrNGKLFLgVGSSDLSTRIYSLA 786
Cdd:cd00200  147 ----GTFVASSSQDGTIKLWD--LRTGKCVATLT---GHTGEVNSVAFSP---DGEKLL-SSSSDGTIKLWDLS 207
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 53-87 1.91e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 1.91e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 398366117    53 ATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK 87
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
53-86 4.46e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.65  E-value: 4.46e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 398366117   53 ATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW 86
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 650-682 1.64e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.64e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 398366117   650 KPHTRIIWDADWAPleFGNVFVTASRDKTVKVW 682
Cdd:smart00320   9 KGHTGPVTSVAFSP--DGKYLASGSDDGTIKLW 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 52-413 2.81e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.87  E-value: 2.81e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117  52 YATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWkftDYSHLQCIQTIQ-HYS--KTIVALSALPSLISVGCaDGTISI 128
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW---DLETGELLRTLKgHTGpvRDVAASADGTYLASGSS-DKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 129 WrqNIQNDEfgLAHEFTikkGFF-YPLCLSLSKveeKKYLLAIGGTNVNVFIASfilsdsgIEKCRVVAELEGHEDWVKS 207
Cdd:cd00200   78 W--DLETGE--CVRTLT---GHTsYVSSVAFSP---DGRILSSSSRDKTIKVWD-------VETGKCLTTLRGHTDWVNS 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 208 LAFrhqeTPGDYLLCSGSQDRYIRLWRIRINDLIddseedskkltllsnkqykfqiddelrvginfeALIMGHDDWISSL 287
Cdd:cd00200  141 VAF----SPDGTFVASSSQDGTIKLWDLRTGKCV---------------------------------ATLTGHTGEVNSV 183

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 288 QWHESRLQLLAATADTSLMVWEPDetSGIWVCSLRlgemsskgastatGSSGGFWSCLWFTHERMdFF--LTNGKTGSWR 365
Cdd:cd00200  184 AFSPDGEKLLSSSSDGTIKLWDLS--TGKCLGTLR-------------GHENGVNSVAFSPDGYL-LAsgSEDGTIRVWD 247

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 398366117 366 MWATKdniiCDQRLgiSGATKDVTDIAWSPSGEYLLATSLDQTTRLFA 413
Cdd:cd00200  248 LRTGE----CVQTL--SGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 18-309 3.14e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.21  E-value: 3.14e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117  18 TQVSDIHKVKKIVAFGAGKTIALWDPiepNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTDYshlQCI 97
Cdd:cd00200   55 RDVAASADGTYLASGSSDKTIRLWDL---ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG---KCL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117  98 QTIQHYSKTIVALSALPS--LISVGCADGTISIWRqniqNDEFGLAHEFTIKKGFFYPLCLSlskveEKKYLLAIGGTNv 175
Cdd:cd00200  129 TTLRGHTDWVNSVAFSPDgtFVASSSQDGTIKLWD----LRTGKCVATLTGHTGEVNSVAFS-----PDGEKLLSSSSD- 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 176 nvfiASFILSDSGIEKCrvVAELEGHEDWVKSLAFrhqeTPGDYLLCSGSQDRYIRLWRIRindliddSEEDSKKLTlls 255
Cdd:cd00200  199 ----GTIKLWDLSTGKC--LGTLRGHENGVNSVAF----SPDGYLLASGSEDGTIRVWDLR-------TGECVQTLS--- 258

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 398366117 256 nkqykfqiddelrvginfealimGHDDWISSLQWHESRLQLLAATADTSLMVWE 309
Cdd:cd00200  259 -----------------------GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
27-411 9.43e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 119.63  E-value: 9.43e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117  27 KKIVAFGAGKTIALWDPiepNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWkftDYSHLQCIQTIQHYSKT 106
Cdd:COG2319   91 RLLASASADGTVRLWDL---ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW---DLATGKLLRTLTGHSGA 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 107 IVALSALP--SLISVGCADGTISIWrqNIQNDEfgLAHEFTIKKGFFYPLCLSL-SKveekkyLLAIGGtnvnvfiasfi 183
Cdd:COG2319  165 VTSVAFSPdgKLLASGSDDGTVRLW--DLATGK--LLRTLTGHTGAVRSVAFSPdGK------LLASGS----------- 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 184 lSDSGI-----EKCRVVAELEGHEDWVKSLAFrhqeTPGDYLLCSGSQDRYIRLWRIrindliddseEDSKKLTLLSnkq 258
Cdd:COG2319  224 -ADGTVrlwdlATGKLLRTLTGHSGSVRSVAF----SPDGRLLASGSADGTVRLWDL----------ATGELLRTLT--- 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 259 ykfqiddelrvginfealimGHDDWISSLQWHESRLQLLAATADTSLMVWEPD--------ETSGIWVCSLRLgemSSKG 330
Cdd:COG2319  286 --------------------GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtgkllrtlTGHTGAVRSVAF---SPDG 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 331 ASTATGSSGgfwsclwfthermdffltngktGSWRMWATKDNiICDQRLgiSGATKDVTDIAWSPSGEYLLATSLDQTTR 410
Cdd:COG2319  343 KTLASGSDD----------------------GTVRLWDLATG-ELLRTL--TGHTGAVTSVAFSPDGRTLASGSADGTVR 397


                 .
gi 398366117 411 L 411
Cdd:COG2319  398 L 398
WD40 COG2319
WD40 repeat [General function prediction only];
27-311 6.49e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 6.49e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117  27 KKIVAFGAGKTIALWDPiepNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWkftDYSHLQCIQTIQHYSKT 106
Cdd:COG2319  175 KLLASGSDDGTVRLWDL---ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW---DLATGKLLRTLTGHSGS 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 107 IVALSALP--SLISVGCADGTISIWrqNIQNDEfgLAHEFTIKKGFFYPLCLSL-SKveekkyLLAIGGTNVNVFIASfi 183
Cdd:COG2319  249 VRSVAFSPdgRLLASGSADGTVRLW--DLATGE--LLRTLTGHSGGVNSVAFSPdGK------LLASGSDDGTVRLWD-- 316

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 184 lsdsgIEKCRVVAELEGHEDWVKSLAFrhqeTPGDYLLCSGSQDRYIRLWRIrindliddseEDSKKLTLLSnkqykfqi 263
Cdd:COG2319  317 -----LATGKLLRTLTGHTGAVRSVAF----SPDGKTLASGSDDGTVRLWDL----------ATGELLRTLT-------- 369

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 398366117 264 ddelrvginfealimGHDDWISSLQWHESRLQLLAATADTSLMVWEPD 311
Cdd:COG2319  370 ---------------GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
29-468 2.19e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.37  E-value: 2.19e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117  29 IVAFGAGKTIALWDPIEPnnkGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWkftDYSHLQCIQTIQHYSKTIV 108
Cdd:COG2319   51 LAAGAGDLTLLLLDAAAG---ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW---DLATGLLLRTLTGHTGAVR 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 109 ALSALP--SLISVGCADGTISIWrqNIQNDEfgLAHEFTIKKGFFYPLCLSLSkveekKYLLAIGGTN--VNVFIAsfil 184
Cdd:COG2319  125 SVAFSPdgKTLASGSADGTVRLW--DLATGK--LLRTLTGHSGAVTSVAFSPD-----GKLLASGSDDgtVRLWDL---- 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 185 sDSGiekcRVVAELEGHEDWVKSLAFrhqeTP-GDYLLcSGSQDRYIRLWRIrindliddseEDSKKLTLLSnkqykfqi 263
Cdd:COG2319  192 -ATG----KLLRTLTGHTGAVRSVAF----SPdGKLLA-SGSADGTVRLWDL----------ATGKLLRTLT-------- 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 264 ddelrvginfealimGHDDWISSLQWHESRLQLLAATADTSLMVWEPDetsgiwvcslrlgemSSKGASTATGSSGGFWS 343
Cdd:COG2319  244 ---------------GHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA---------------TGELLRTLTGHSGGVNS 293

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 344 cLWFTHERmDFFLTNGKTGSWRMWATKDNiicDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLfapwiYDASGRK 423
Cdd:COG2319  294 -VAFSPDG-KLLASGSDDGTVRLWDLATG---KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL-----WDLATGE 363

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 398366117 424 rEIATWHEFSRPqihgydmicVETVT----DTRFVSGGDEKILRSFDLP 468
Cdd:COG2319  364 -LLRTLTGHTGA---------VTSVAfspdGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
274-733 8.62e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.36  E-value: 8.62e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 274 EALIMGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWvcslrlgemsskgasTATGSSGGFWSCLWFTHERMd 353
Cdd:COG2319   29 LLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLA---------------TLLGHTAAVLSVAFSPDGRL- 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 354 fFLTNGKTGSWRMWATKDNIIcdqRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLfapwiYDASGRKrEIATWHEfs 433
Cdd:COG2319   93 -LASASADGTVRLWDLATGLL---LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL-----WDLATGK-LLRTLTG-- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 434 rpqiHGYDMICVETVTD-TRFVSGGDEKILRSFDLPKGvaGMLQKFVG-------IQFeekSemPDSATVPVLGLSNKAG 505
Cdd:COG2319  161 ----HSGAVTSVAFSPDgKLLASGSDDGTVRLWDLATG--KLLRTLTGhtgavrsVAF---S--PDGKLLASGSADGTVR 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 506 eddaneddeeeeggnketpditdplsllecppmedqlqrhlLW-----PEVEKLYGHGFEITCLDISPDQKLIASACRSN 580
Cdd:COG2319  230 -----------------------------------------LWdlatgKLLRTLTGHSGSVRSVAFSPDGRLLASGSADG 268

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 581 nvqnaVIRIFSTENWLEIKPaLPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELrfkneKPHTRIIWDAD 660
Cdd:COG2319  269 -----TVRLWDLATGELLRT-LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-----TGHTGAVRSVA 337

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398366117 661 WAPLefGNVFVTASRDKTVKVWrhqkEPADDYVLEASIKHTKAVTAISIHDSmirEKILISVGlENGEIYLYS 733
Cdd:COG2319  338 FSPD--GKTLASGSDDGTVRLW----DLATGELLRTLTGHTGAVTSVAFSPD---GRTLASGS-ADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
547-786 5.20e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.97  E-value: 5.20e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 547 LW-----PEVEKLYGHGFEITCLDISPDQKLIASACRSNnvqnaVIRIFSTENWLEIKpALPFHSLTITRLKFSKDGKFL 621
Cdd:COG2319  146 LWdlatgKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDG-----TVRLWDLATGKLLR-TLTGHTGAVRSVAFSPDGKLL 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 622 LSVCRDRKWALWerNMEDNTFELRFkneKPHTRIIWDADWAPLefGNVFVTASRDKTVKVWRhqkePADDYVLEASIKHT 701
Cdd:COG2319  220 ASGSADGTVRLW--DLATGKLLRTL---TGHSGSVRSVAFSPD--GRLLASGSADGTVRLWD----LATGELLRTLTGHS 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 702 KAVTAISIH-DSmireKILISVGlENGEIYLYSYTLGKfeLITQLNEditPADKITRLRWShlkRNGKlFLGVGSSDLST 780
Cdd:COG2319  289 GGVNSVAFSpDG----KLLASGS-DDGTVRLWDLATGK--LLRTLTG---HTGAVRSVAFS---PDGK-TLASGSDDGTV 354


                 ....*.
gi 398366117 781 RIYSLA 786
Cdd:COG2319  355 RLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
554-786 7.82e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.59  E-value: 7.82e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 554 LYGHGFEITCLDISPDQKLIASACRSNnvqnaVIRIFSTENWLEIKPaLPFHSLTITRLKFSKDGKFLLSVCRDRKWALW 633
Cdd:COG2319  116 LTGHTGAVRSVAFSPDGKTLASGSADG-----TVRLWDLATGKLLRT-LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 634 erNMEDNTFELRFkneKPHTRIIWDADWAPleFGNVFVTASRDKTVKVWRhqkepADDYVLEASIK-HTKAVTAISIH-D 711
Cdd:COG2319  190 --DLATGKLLRTL---TGHTGAVRSVAFSP--DGKLLASGSADGTVRLWD-----LATGKLLRTLTgHSGSVRSVAFSpD 257

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 398366117 712 SmireKILISVGlENGEIYLYSytLGKFELITQLNediTPADKITRLRWShlkRNGKLFLgVGSSDLSTRIYSLA 786
Cdd:COG2319  258 G----RLLASGS-ADGTVRLWD--LATGELLRTLT---GHSGGVNSVAFS---PDGKLLA-SGSDDGTVRLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 554-786 2.83e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.85  E-value: 2.83e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 554 LYGHGFEITCLDISPDQKLIASACRSNnvqnaVIRIFSTENWLEIKpALPFHSLTITRLKFSKDGKFLLSVCRDRKWALW 633
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDG-----TIKVWDLETGELLR-TLKGHTGPVRDVAASADGTYLASGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 634 ERNMEDNTFELrfkneKPHTRIIWDADWAPLefGNVFVTASRDKTVKVWrhqkePADDYVLEASIK-HTKAVTAISIHDS 712
Cdd:cd00200   79 DLETGECVRTL-----TGHTSYVSSVAFSPD--GRILSSSSRDKTIKVW-----DVETGKCLTTLRgHTDWVNSVAFSPD 146

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398366117 713 mireKILISVGLENGEIYLYSytLGKFELITQLNediTPADKITRLRWSHlkrNGKLFLgVGSSDLSTRIYSLA 786
Cdd:cd00200  147 ----GTFVASSSQDGTIKLWD--LRTGKCVATLT---GHTGEVNSVAFSP---DGEKLL-SSSSDGTIKLWDLS 207
WD40 COG2319
WD40 repeat [General function prediction only];
193-683 7.96e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.50  E-value: 7.96e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 193 RVVAELEGHEDWVKSLAFrhqeTP-GDYLLcSGSQDRYIRLWRIrindliddseEDSKKLTLLSnkqykfqiddelrvgi 271
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAF----SPdGKTLA-SGSADGTVRLWDL----------ATGKLLRTLT---------------- 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 272 nfealimGHDDWISSLQWHESRLQLLAATADTSLMVWEPDETSGIWVcslrlgemsskgastatgssggfwsclwfther 351
Cdd:COG2319  160 -------GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT--------------------------------- 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 352 mdffltngktgswrmwatkdniicdqrlgISGATKDVTDIAWSPSGEYLLATSLDQTTRLfapwiYDASGRKrEIATWHE 431
Cdd:COG2319  200 -----------------------------LTGHTGAVRSVAFSPDGKLLASGSADGTVRL-----WDLATGK-LLRTLTG 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 432 FSRPqihgydmicVETVT----DTRFVSGGDEKILRSFDLPKGvagmlqkfvgiqfeeksempdsatvpvlglsnkaged 507
Cdd:COG2319  245 HSGS---------VRSVAfspdGRLLASGSADGTVRLWDLATG------------------------------------- 278

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 508 daneddeeeeggnketpditdplsllecppmedqlqrhllwPEVEKLYGHGFEITCLDISPDQKLIASACRSNnvqnaVI 587
Cdd:COG2319  279 -----------------------------------------ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDG-----TV 312

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 588 RIFSTENWLEIKPaLPFHSLTITRLKFSKDGKFLLSVCRDRKWALWerNMEDNTFELRFKNekpHTRIIWDADWAPleFG 667
Cdd:COG2319  313 RLWDLATGKLLRT-LTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW--DLATGELLRTLTG---HTGAVTSVAFSP--DG 384

                        490
                 ....*....|....*.
gi 398366117 668 NVFVTASRDKTVKVWR 683
Cdd:COG2319  385 RTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 550-784 2.42e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.46  E-value: 2.42e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 550 EVEKLYGHGFEITCLDISPDQKLIASACRSNnvqnaVIRIFSTENwLEIKPALPFHSLTITRLKFSKDGKFLLSVCRDRK 629
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDK-----TIKVWDVET-GKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 630 WALWerNMEDNTFELRFKNekpHTRIIWDADWAPLefGNVFVTASRDKTVKVWRHQKEPAdDYVLEAsikHTKAVTAISI 709
Cdd:cd00200  159 IKLW--DLRTGKCVATLTG---HTGEVNSVAFSPD--GEKLLSSSSDGTIKLWDLSTGKC-LGTLRG---HENGVNSVAF 227

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 398366117 710 HDSmireKILISVGLENGEIYLYSytLGKFELITQLNEditPADKITRLRWShlkrNGKLFLGVGSSDLSTRIYS 784
Cdd:cd00200  228 SPD----GYLLASGSEDGTIRVWD--LRTGECVQTLSG---HTNSVTSLAWS----PDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 277-683 1.14e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 72.37  E-value: 1.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 277 IMGHDDWISSLQWHESRLQLLAATADTSLMVWepdetsgiwvcSLRLGEMSSKGastaTGSSGGFWSCLWFTHErmDFFL 356
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVW-----------DLETGELLRTL----KGHTGPVRDVAASADG--TYLA 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 357 TNGKTGSWRMWATKDNIICDQrlgISGATKDVTDIAWSPSGEYLLATSLDQTTRLfapwiydasgrkreiatWHEFSRPQ 436
Cdd:cd00200   68 SGSSDKTIRLWDLETGECVRT---LTGHTSYVSSVAFSPDGRILSSSSRDKTIKV-----------------WDVETGKC 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 437 I-----HGYDMICVETVTDTRFVSGG-DEKILRSFDLPKGvagmlqkfvgiqfeeksempdsatvpvlglsnkageddan 510
Cdd:cd00200  128 LttlrgHTDWVNSVAFSPDGTFVASSsQDGTIKLWDLRTG---------------------------------------- 167

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 511 eddeeeeggnketpditdplsllECppmedqlqrhllwpeVEKLYGHGFEITCLDISPDQKLIASACRSNnvqnaVIRIF 590
Cdd:cd00200  168 -----------------------KC---------------VATLTGHTGEVNSVAFSPDGEKLLSSSSDG-----TIKLW 204

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 591 STENWLEIKPaLPFHSLTITRLKFSKDGKFLLSVCRDRKWALWERNMEDNTFELrfkneKPHTRIIWDADWAPLefGNVF 670
Cdd:cd00200  205 DLSTGKCLGT-LRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTL-----SGHTNSVTSLAWSPD--GKRL 276

                        410
                 ....*....|...
gi 398366117 671 VTASRDKTVKVWR 683
Cdd:cd00200  277 ASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
548-786 1.14e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.79  E-value: 1.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 548 WPEVEKLYGHGFEITCLDISPDQKLIASACRSNNVqnaviRIFSTENWLEIKPaLPFHSLTITRLKFSKDGKFLLSVCRD 627
Cdd:COG2319   68 GALLATLLGHTAAVLSVAFSPDGRLLASASADGTV-----RLWDLATGLLLRT-LTGHTGAVRSVAFSPDGKTLASGSAD 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 628 RKWALWerNMEDNTFELRFkneKPHTRIIWDADWAPLefGNVFVTASRDKTVKVWRhqkePADDYVLEASIKHTKAVTAI 707
Cdd:COG2319  142 GTVRLW--DLATGKLLRTL---TGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWD----LATGKLLRTLTGHTGAVRSV 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366117 708 SIH-DSmireKILISVGlENGEIYLYSYTLGKfeLITQLNEDitpADKITRLRWSHlkrNGKLFLgVGSSDLSTRIYSLA 786
Cdd:COG2319  211 AFSpDG----KLLASGS-ADGTVRLWDLATGK--LLRTLTGH---SGSVRSVAFSP---DGRLLA-SGSADGTVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
27-90 9.86e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 9.86e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398366117  27 KKIVAFGAGKTIALWDPiepNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWKFTD 90
Cdd:COG2319  343 KTLASGSDDGTVRLWDL---ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 53-87 1.91e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 1.91e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 398366117    53 ATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK 87
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
53-86 4.46e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.65  E-value: 4.46e-08
                          10        20        30
                  ....*....|....*....|....*....|....
gi 398366117   53 ATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIW 86
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 193-233 6.43e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 6.43e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 398366117   193 RVVAELEGHEDWVKSLAFrhqeTPGDYLLCSGSQDRYIRLW 233
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAF----SPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
193-233 1.87e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.87e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 398366117  193 RVVAELEGHEDWVKSLAFrhqeTPGDYLLCSGSQDRYIRLW 233
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAF----SPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 650-682 1.64e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.64e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 398366117   650 KPHTRIIWDADWAPleFGNVFVTASRDKTVKVW 682
Cdd:smart00320   9 KGHTGPVTSVAFSP--DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
381-412 7.27e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 7.27e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 398366117  381 ISGATKDVTDIAWSPSGEYLLATSLDQTTRLF 412
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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