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Conserved domains on  [gi|398366145|ref|NP_011722|]
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ubiquitin-binding ESCRT-I subunit protein MVB12 [Saccharomyces cerevisiae S288C]

Protein Classification

Mvb12 domain-containing protein( domain architecture ID 10559604)

Mvb12 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mvb12 pfam09452
ESCRT-I subunit Mvb12; The endosomal sorting complex required for transport (ESCRT) complexes ...
 9-98 5.76e-50

ESCRT-I subunit Mvb12; The endosomal sorting complex required for transport (ESCRT) complexes play a critical role in receptor down-regulation and retroviral budding. A new component of the ESCRT-I complex was identified, multivesicular body sorting factor of 12 kD (Mvb12), which binds to the coiled-coil domain of the ESCRT-I subunit vacuolar protein sorting 23 (Vps23).


:

Pssm-ID: 370502  Cd Length: 90  Bit Score: 152.85  E-value: 5.76e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366145    9 LRRIPLYNKYGKDFPQETVTRFQMPEFKLPALQPTRDLLCPWYEECDNITKVCQLHDSSNKKFDQWYKEQYLSKKPPGIV 88
Cdd:pfam09452   1 LRKIPLYNKFGVDFPREKLPKLTVPELKLPPLQPTKEMFEPWYKECDQLVESCEQHDKSGKEFDQWYKEKYLSKKPPGLL 80

                          90
                  ....*....|
gi 398366145   89 GNTLLSPSRK 98
Cdd:pfam09452  81 ESTVLSPSKR 90
 
Name Accession Description Interval E-value
Mvb12 pfam09452
ESCRT-I subunit Mvb12; The endosomal sorting complex required for transport (ESCRT) complexes ...
 9-98 5.76e-50

ESCRT-I subunit Mvb12; The endosomal sorting complex required for transport (ESCRT) complexes play a critical role in receptor down-regulation and retroviral budding. A new component of the ESCRT-I complex was identified, multivesicular body sorting factor of 12 kD (Mvb12), which binds to the coiled-coil domain of the ESCRT-I subunit vacuolar protein sorting 23 (Vps23).


Pssm-ID: 370502  Cd Length: 90  Bit Score: 152.85  E-value: 5.76e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366145    9 LRRIPLYNKYGKDFPQETVTRFQMPEFKLPALQPTRDLLCPWYEECDNITKVCQLHDSSNKKFDQWYKEQYLSKKPPGIV 88
Cdd:pfam09452   1 LRKIPLYNKFGVDFPREKLPKLTVPELKLPPLQPTKEMFEPWYKECDQLVESCEQHDKSGKEFDQWYKEKYLSKKPPGLL 80

                          90
                  ....*....|
gi 398366145   89 GNTLLSPSRK 98
Cdd:pfam09452  81 ESTVLSPSKR 90
 
Name Accession Description Interval E-value
Mvb12 pfam09452
ESCRT-I subunit Mvb12; The endosomal sorting complex required for transport (ESCRT) complexes ...
 9-98 5.76e-50

ESCRT-I subunit Mvb12; The endosomal sorting complex required for transport (ESCRT) complexes play a critical role in receptor down-regulation and retroviral budding. A new component of the ESCRT-I complex was identified, multivesicular body sorting factor of 12 kD (Mvb12), which binds to the coiled-coil domain of the ESCRT-I subunit vacuolar protein sorting 23 (Vps23).


Pssm-ID: 370502  Cd Length: 90  Bit Score: 152.85  E-value: 5.76e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366145    9 LRRIPLYNKYGKDFPQETVTRFQMPEFKLPALQPTRDLLCPWYEECDNITKVCQLHDSSNKKFDQWYKEQYLSKKPPGIV 88
Cdd:pfam09452   1 LRKIPLYNKFGVDFPREKLPKLTVPELKLPPLQPTKEMFEPWYKECDQLVESCEQHDKSGKEFDQWYKEKYLSKKPPGLL 80

                          90
                  ....*....|
gi 398366145   89 GNTLLSPSRK 98
Cdd:pfam09452  81 ESTVLSPSKR 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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