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Conserved domains on  [gi|330443580|ref|NP_011816|]
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siderophore transporter [Saccharomyces cerevisiae S288C]

Protein Classification

ARN family MFS transporter( domain architecture ID 13023295)

ARN family MFS transporter similar to yeast siderophore iron transporter and glutathione exchanger

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_ARN_like cd17322
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...
 69-581 0e+00

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340880 [Multi-domain]  Cd Length: 514  Bit Score: 725.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  69 KAIFLFSAFICTFAYGLDSSIRGTYMTYAMNSYSAHSLISTVSVIVLMISAVSQVIFGGLSDIFGRLTLFLVSIVLYIVG 148
Cdd:cd17322    1 LIILFFSLFLCGFAIGLDGQIRYSYQAYATSSFSKHSLLSTINVVNNIVSAVSQPPYAKLSDVFGRLELFLVSLLLYVVG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 149 TIIQSQAYDVQRYAAGAVFYYVGLVGVMLQVVLMLSDNSSLKWRLFYTLIPSWPSIITTWVSGSVVEAANPLENWSWNIA 228
Cdd:cd17322   81 TIIMAASTNVQTYAAGSVFYNAGYTGLNLLLTLILADFSSLKNRGFASAIPSLPYIITTWIGGNIAQAALPNSNWRWGYG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 229 MWAFIFPLCCIPLILCMLHMRWKVRNDVEWKELQDEKSYYQTHGLVQMLVQLFWKLDVVGVLLFTAGVGCILVPLTLAGG 308
Cdd:cd17322  161 MWAIILPLSSLPLVLCLLYMQRKARKDGEIKELKNQETEEQTGGLSQNLVKLFWKLDIFGVILLTAGLGLILVPLTLAGG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 309 VSTNWRNSKIIGPFVLGFVLVPGFIYWESRLALVPFAPFKLLKDRGVWAPLGIMFFICFVYQMAAGYLYTILVVAVDESA 388
Cdd:cd17322  241 AKSKWKNSSIIAMIVLGGVLLVAFLLWEAKFAKYPFLPFRLLKDRTILAACLIDFFYFFSYYIFSDYLYTVLQVAVGESI 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 389 SSATRIINLYSFVTAVVAPFLGLIVTRSSRLKSYIIFGGSLYFITMGLFYRYRSGQDADGGIIAGMVIWGLSSCLFDYPT 468
Cdd:cd17322  321 TSATRITNLYSFVSTVAGIFVGFLIRKTRRYKVLVIIGVPLYIVGMGLLIRYRGGSGSHGGIIGALILIGIGGGLFTYPV 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 469 IVSIQSVTSHENMATVTALNYTVFRIGGAVAAAISGAIWTQSLYPKLLHYMGDADLATAAYGSPLTF-ILSNPWGTPVRS 547
Cdd:cd17322  401 QVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAISGAIWTQTLPKKLLKNLPDSLKATAAYIFPSTFvILSYPWGTPERD 480

                        490       500       510
                 ....*....|....*....|....*....|....
gi 330443580 548 AMVEAYRHVQKYEVIVALVFSAPMFLLTFCVRDP 581
Cdd:cd17322  481 AIIESYRYVQRILLIVALVFSAPMFALMFFLRNP 514
 
Name Accession Description Interval E-value
MFS_ARN_like cd17322
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...
 69-581 0e+00

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340880 [Multi-domain]  Cd Length: 514  Bit Score: 725.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  69 KAIFLFSAFICTFAYGLDSSIRGTYMTYAMNSYSAHSLISTVSVIVLMISAVSQVIFGGLSDIFGRLTLFLVSIVLYIVG 148
Cdd:cd17322    1 LIILFFSLFLCGFAIGLDGQIRYSYQAYATSSFSKHSLLSTINVVNNIVSAVSQPPYAKLSDVFGRLELFLVSLLLYVVG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 149 TIIQSQAYDVQRYAAGAVFYYVGLVGVMLQVVLMLSDNSSLKWRLFYTLIPSWPSIITTWVSGSVVEAANPLENWSWNIA 228
Cdd:cd17322   81 TIIMAASTNVQTYAAGSVFYNAGYTGLNLLLTLILADFSSLKNRGFASAIPSLPYIITTWIGGNIAQAALPNSNWRWGYG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 229 MWAFIFPLCCIPLILCMLHMRWKVRNDVEWKELQDEKSYYQTHGLVQMLVQLFWKLDVVGVLLFTAGVGCILVPLTLAGG 308
Cdd:cd17322  161 MWAIILPLSSLPLVLCLLYMQRKARKDGEIKELKNQETEEQTGGLSQNLVKLFWKLDIFGVILLTAGLGLILVPLTLAGG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 309 VSTNWRNSKIIGPFVLGFVLVPGFIYWESRLALVPFAPFKLLKDRGVWAPLGIMFFICFVYQMAAGYLYTILVVAVDESA 388
Cdd:cd17322  241 AKSKWKNSSIIAMIVLGGVLLVAFLLWEAKFAKYPFLPFRLLKDRTILAACLIDFFYFFSYYIFSDYLYTVLQVAVGESI 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 389 SSATRIINLYSFVTAVVAPFLGLIVTRSSRLKSYIIFGGSLYFITMGLFYRYRSGQDADGGIIAGMVIWGLSSCLFDYPT 468
Cdd:cd17322  321 TSATRITNLYSFVSTVAGIFVGFLIRKTRRYKVLVIIGVPLYIVGMGLLIRYRGGSGSHGGIIGALILIGIGGGLFTYPV 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 469 IVSIQSVTSHENMATVTALNYTVFRIGGAVAAAISGAIWTQSLYPKLLHYMGDADLATAAYGSPLTF-ILSNPWGTPVRS 547
Cdd:cd17322  401 QVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAISGAIWTQTLPKKLLKNLPDSLKATAAYIFPSTFvILSYPWGTPERD 480

                        490       500       510
                 ....*....|....*....|....*....|....
gi 330443580 548 AMVEAYRHVQKYEVIVALVFSAPMFLLTFCVRDP 581
Cdd:cd17322  481 AIIESYRYVQRILLIVALVFSAPMFALMFFLRNP 514
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 28-595 3.67e-10

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 62.76  E-value: 3.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580   28 DEKMDDDSSPRDEMKdklkgTKSLIIRKSELMAKKYDTWQLKAIFL-FSAFICTFAYGLDSSirGTYMTYAMNSYSAHSL 106
Cdd:pfam06609   7 EEGLDLESQPDDRLR-----AKALATSAAELPDGYYRSPRIIASFAaFSLNVCATYFVLQAS--ASALPNILQDIGQSEN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  107 ISTVSVIVLMISAVSQVIFGGLSDIFGRLTLFLVSIVLYIVGTIIQSQAYDVQRYAAGAVFYYVGlVGVMLQVVLMLSDN 186
Cdd:pfam06609  80 QGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGVA-AGPAGASPLFIGEL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  187 SSLKWRLFYTLIPSWPSIITTWVSGSVVEAANPLENWSWNIAMWaFIFPLCCIPLILCMLHmrwkvrndvewkelqdEKS 266
Cdd:pfam06609 159 MSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIY-IIMSAIAVLLIIIWYH----------------PPS 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  267 YYQTHGLVQMLVQLFWKLDVVGVLLFTAGVGCILVPLTLAGGVSTNWRNSKIIGPFVLGFVLVPGFIYWESRLALV-PFA 345
Cdd:pfam06609 222 FAQLHGKKARKRDELAKLDWIGIFLVIAGTSLFLLGVSWGGKPNNPWNSAKIIGLISSGAGSLVIFALYEVFGKPEqPII 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  346 PFKLLKD-RGvwaplgimfFIC-FVYQMAAGYLYTILVVAVDEsassatRIINLY-----------------SFVTAVVA 406
Cdd:pfam06609 302 PPALFKDtRG---------FVCiLIISSIMGAMHLCLTIIYPQ------QVINIFgsslknweetawmsataSFGTGAGV 366

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  407 PFLGLIVTRSSRLKSYIIFGGslYFITMGLFYRYRSGQDADGGIIAGMVIWGLSSCLFDYPTIVSIQSVTSHENMATV-- 484
Cdd:pfam06609 367 MILGNLFHLIRHIRWQILVGA--LWLTAFLGAMSSINRDNKNAAIALSFFSGFVVAWAQDITMLLVQFITTDEDLGVAfa 444

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  485 -------------TALNYTVF------RIGGAVAAAISGAIWTQSLYPKLLHYM--GDADLATAAYGspltfiLSNPWGT 543
Cdd:pfam06609 445 vvaaarpfagsifTAAFISLYsnqypkEIASHLSSALRGTDFPQASFPSLLEAAksGRIDAVKALPG------MTNEIAA 518

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....
gi 330443580  544 PVRSAMVEAYRHVQKYEVIVALVFSAPMFLLTFCVR--DPRLTEDFAQKLPDRE 595
Cdd:pfam06609 519 VVSQAMADSYTASYANVYYFAMALGVIPIIASLCMRdfDCYLTDHVPHQIYDRK 572
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
69-499 2.70e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 56.14  E-value: 2.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  69 KAIFLFSAFICTFAYGLDSSIRGTYMTYAMNSYSA-HSLISTVSVIVLMISAVSQVIFGGLSDIFGRLTLFLVSIVLYIV 147
Cdd:COG2814    8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGAsPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 148 GTIIQSQAYDVQRYAAGAVFyyVGLVGVMLQVVLMlsdnsslkwrlfytlipswpSIITTWVSGSVVEAANPLENWSWNI 227
Cdd:COG2814   88 GSLLCALAPSLWLLLAARFL--QGLGAGALFPAAL--------------------ALIADLVPPERRGRALGLLGAGLGL 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 228 AMwaFIFPLcciplilcmlhmrwkvrndvewkelqdeksyyqthgLVQMLVQLF-WKldvvGVLLFTAGVGCILvpltla 306
Cdd:COG2814  146 GP--ALGPL------------------------------------LGGLLADLFgWR----WVFLVNAVLALLA------ 177

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 307 ggvstnwrnskiigpFVLGFVLVPGFIYWESRLALVPFapFKLLKDRGVWAPLGIMFFICFVYQMAAGYLYTILVVAVDE 386
Cdd:COG2814  178 ---------------LLLLLRLLPESRPAARARLRGSL--RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 387 SASSATRIINLYSFVTAVVAPFLGLIVTRSSRLKSyIIFGGSLYFITMGLFYRYRSGqdadGGIIAGMVIWGLSSCLFDY 466
Cdd:COG2814  241 SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRL-LLIGLLLLALGLLLLALAGSL----WLLLLALFLLGFGFGLLFP 315

                        410       420       430
                 ....*....|....*....|....*....|...
gi 330443580 467 PTIVSIQSVTSHENMATVTALNYTVFRIGGAVA 499
Cdd:COG2814  316 LLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
 
Name Accession Description Interval E-value
MFS_ARN_like cd17322
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...
 69-581 0e+00

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340880 [Multi-domain]  Cd Length: 514  Bit Score: 725.64  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  69 KAIFLFSAFICTFAYGLDSSIRGTYMTYAMNSYSAHSLISTVSVIVLMISAVSQVIFGGLSDIFGRLTLFLVSIVLYIVG 148
Cdd:cd17322    1 LIILFFSLFLCGFAIGLDGQIRYSYQAYATSSFSKHSLLSTINVVNNIVSAVSQPPYAKLSDVFGRLELFLVSLLLYVVG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 149 TIIQSQAYDVQRYAAGAVFYYVGLVGVMLQVVLMLSDNSSLKWRLFYTLIPSWPSIITTWVSGSVVEAANPLENWSWNIA 228
Cdd:cd17322   81 TIIMAASTNVQTYAAGSVFYNAGYTGLNLLLTLILADFSSLKNRGFASAIPSLPYIITTWIGGNIAQAALPNSNWRWGYG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 229 MWAFIFPLCCIPLILCMLHMRWKVRNDVEWKELQDEKSYYQTHGLVQMLVQLFWKLDVVGVLLFTAGVGCILVPLTLAGG 308
Cdd:cd17322  161 MWAIILPLSSLPLVLCLLYMQRKARKDGEIKELKNQETEEQTGGLSQNLVKLFWKLDIFGVILLTAGLGLILVPLTLAGG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 309 VSTNWRNSKIIGPFVLGFVLVPGFIYWESRLALVPFAPFKLLKDRGVWAPLGIMFFICFVYQMAAGYLYTILVVAVDESA 388
Cdd:cd17322  241 AKSKWKNSSIIAMIVLGGVLLVAFLLWEAKFAKYPFLPFRLLKDRTILAACLIDFFYFFSYYIFSDYLYTVLQVAVGESI 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 389 SSATRIINLYSFVTAVVAPFLGLIVTRSSRLKSYIIFGGSLYFITMGLFYRYRSGQDADGGIIAGMVIWGLSSCLFDYPT 468
Cdd:cd17322  321 TSATRITNLYSFVSTVAGIFVGFLIRKTRRYKVLVIIGVPLYIVGMGLLIRYRGGSGSHGGIIGALILIGIGGGLFTYPV 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 469 IVSIQSVTSHENMATVTALNYTVFRIGGAVAAAISGAIWTQSLYPKLLHYMGDADLATAAYGSPLTF-ILSNPWGTPVRS 547
Cdd:cd17322  401 QVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAISGAIWTQTLPKKLLKNLPDSLKATAAYIFPSTFvILSYPWGTPERD 480

                        490       500       510
                 ....*....|....*....|....*....|....
gi 330443580 548 AMVEAYRHVQKYEVIVALVFSAPMFLLTFCVRDP 581
Cdd:cd17322  481 AIIESYRYVQRILLIVALVFSAPMFALMFFLRNP 514
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 70-592 9.66e-32

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 129.28  E-value: 9.66e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  70 AIFLFSAFICTFAYGLDSSIRGTYMTYAMNSysahSLISTVSVIVLMISAVSQVIFGGLSDIFGRLTLFLVSIVLYIVGT 149
Cdd:cd06179    1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPS----SNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 150 IIQSQAYDVQRYAAGAVFYYVGLVGVMLqVVLMLSDNSSLKWRLFYTLIPSWPSIITTWV----SGSVVEAANplENWSW 225
Cdd:cd06179   77 IVAGTAKSVNMLIGGQALIGIGAGTQGL-GAAVASELVPNKYRGLVQGVVNLVASPGSALgpliAGALVEANA--AGWRW 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 226 ----NIAMWAFIFplcciplILCMLHMRwkvrndvewkelqdEKSYYQTHGLVqmLVQLFWKLDVVGVLLFTAGVGCILV 301
Cdd:cd06179  154 ifyiNAIFNALAL-------ILLFFFYH--------------PPPRPQLHGSS--TRQKLKRLDWVGLFLLIAGLVLFLL 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 302 PLTLAGGVSTnWRNSKIIGPFVLGFVLVPGFIYWESRLALVPFAPFKLLKDrgvWAPLGIMFFICFVYQMAAGYLYTILV 381
Cdd:cd06179  211 GLSWGGNPYP-WSSAHVIAPLVIGGVLLIAFGLYEWKGTKDGLLPPRLLFR---GRNFALILIVAFVEGMIFYSLNIFWP 286

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 382 VAVDESASSATRIINLYS----FVTAVVAPFLGLIVTRSSRLKSYIIFGGSLYFITMGLFyrYRSGQDADGGIIAGMVIW 457
Cdd:cd06179  287 QQISLLFTTDPLKAGLYQlpfgLGTLFGAILAGLLLTKIKHIKWQLVAGFVLFTAFLALL--ALITPDNKALAIAFSVLA 364

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 458 GLSSCLFDYPTIVSIQSVTSHENMATVTALNYTVFRIGGAVAAAISGAIWTQSLYPKLLHYMGDA------------DLA 525
Cdd:cd06179  365 GIGIGGPLVLAIVIVQLSVPPEDIGTASGLLGSARALGGAVGTAIFTSILSNRLSKNLPARVAPAaleaglpasslpALL 444

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 330443580 526 TAAYGSPLTFILSNPWGTP-----VRSAMVEAYRHVQKYEVIVALVFSAPMFLLTFCVRD--PRLTEDFAQKLP 592
Cdd:cd06179  445 GALASGNIAALTAVPGINPeiiaaATAALKQAYADSFRYVWYAAIPFGVVAIIAALFLRDidSYMTDHVDARLE 518
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 76-509 2.86e-15

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 77.85  E-value: 2.86e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  76 AFICTFAYGLDSSIRGTYMTYAMNSYSA-HSLISTVSVIVLMISAVSQVIFGGLSDIFGRLTLFLVSIVLYIVGTIIQSQ 154
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLsASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 155 AYDVQRYAAGAVFYYVGLVGVMLQVVLMLSDNSSL----KWRLFYTLIPSWPSIITTWVSGSVVEAAnpLENWSWNIAMW 230
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPErergRALGLLQAFGSVGGILGPLLGGILASSL--GFGWRAVFLIA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 231 AFIFPLCCIPLILCMLHMRWKVRNDVEWKElqdeksyyqthglvqmlvqlfwkldvvgvllftagvgcilvpltlaggvs 310
Cdd:cd06174  159 AALALLAAILLLLVVPDPPESARAKNEEAS-------------------------------------------------- 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 311 tnwrnskiigpfvlgfvlvpgfiywesrLALVPFAPFKLLKDRGVWAPLGIMFFICFVYQMAAGYLYTILVVAVDESASS 390
Cdd:cd06174  189 ----------------------------SKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 391 ATRIINLYSFVTAVVAPFLGLIVTRSSRLKSYIIFGGSLYFITMGLFYRYRSGQdadgGIIAGMVIWGLSSCLFDYPTIV 470
Cdd:cd06174  241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLL----LLLLLLLLLGFGLGGLLPLSFA 316

                        410       420       430
                 ....*....|....*....|....*....|....*....
gi 330443580 471 SIQSVTSHENMATVTALNYTVFRIGGAVAAAISGAIWTQ 509
Cdd:cd06174  317 LIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAA 355
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 28-595 3.67e-10

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 62.76  E-value: 3.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580   28 DEKMDDDSSPRDEMKdklkgTKSLIIRKSELMAKKYDTWQLKAIFL-FSAFICTFAYGLDSSirGTYMTYAMNSYSAHSL 106
Cdd:pfam06609   7 EEGLDLESQPDDRLR-----AKALATSAAELPDGYYRSPRIIASFAaFSLNVCATYFVLQAS--ASALPNILQDIGQSEN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  107 ISTVSVIVLMISAVSQVIFGGLSDIFGRLTLFLVSIVLYIVGTIIQSQAYDVQRYAAGAVFYYVGlVGVMLQVVLMLSDN 186
Cdd:pfam06609  80 QGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGVA-AGPAGASPLFIGEL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  187 SSLKWRLFYTLIPSWPSIITTWVSGSVVEAANPLENWSWNIAMWaFIFPLCCIPLILCMLHmrwkvrndvewkelqdEKS 266
Cdd:pfam06609 159 MSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIY-IIMSAIAVLLIIIWYH----------------PPS 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  267 YYQTHGLVQMLVQLFWKLDVVGVLLFTAGVGCILVPLTLAGGVSTNWRNSKIIGPFVLGFVLVPGFIYWESRLALV-PFA 345
Cdd:pfam06609 222 FAQLHGKKARKRDELAKLDWIGIFLVIAGTSLFLLGVSWGGKPNNPWNSAKIIGLISSGAGSLVIFALYEVFGKPEqPII 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  346 PFKLLKD-RGvwaplgimfFIC-FVYQMAAGYLYTILVVAVDEsassatRIINLY-----------------SFVTAVVA 406
Cdd:pfam06609 302 PPALFKDtRG---------FVCiLIISSIMGAMHLCLTIIYPQ------QVINIFgsslknweetawmsataSFGTGAGV 366

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  407 PFLGLIVTRSSRLKSYIIFGGslYFITMGLFYRYRSGQDADGGIIAGMVIWGLSSCLFDYPTIVSIQSVTSHENMATV-- 484
Cdd:pfam06609 367 MILGNLFHLIRHIRWQILVGA--LWLTAFLGAMSSINRDNKNAAIALSFFSGFVVAWAQDITMLLVQFITTDEDLGVAfa 444

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  485 -------------TALNYTVF------RIGGAVAAAISGAIWTQSLYPKLLHYM--GDADLATAAYGspltfiLSNPWGT 543
Cdd:pfam06609 445 vvaaarpfagsifTAAFISLYsnqypkEIASHLSSALRGTDFPQASFPSLLEAAksGRIDAVKALPG------MTNEIAA 518

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....
gi 330443580  544 PVRSAMVEAYRHVQKYEVIVALVFSAPMFLLTFCVR--DPRLTEDFAQKLPDRE 595
Cdd:pfam06609 519 VVSQAMADSYTASYANVYYFAMALGVIPIIASLCMRdfDCYLTDHVPHQIYDRK 572
MFS_1 pfam07690
Major Facilitator Superfamily;
77-500 1.54e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 56.66  E-value: 1.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580   77 FICTFAYGLDSSIRGTYMTYAMNSY--SAHSLISTVSVIVLMISAVSQVIFGGLSDIFGRLTLFLVSIVLYIVGTIIQSQ 154
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLAEDlgISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  155 AYDVQRYAAGAVFyyVGLVGVMLqvvlmlsdnsslkwrlfytlIPSWPSIITTWVSGSVVEAANPLENWSWNIAmwAFIF 234
Cdd:pfam07690  82 ASSLWLLLVLRVL--QGLGAGAL--------------------FPAALALIADWFPPEERGRALGLVSAGFGLG--AALG 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  235 PLCcIPLILCMLHMRWkvrndvewkelqdeksyyqthglvqmlvqLFWkldVVGVLLFTAGVGCILVPLTLAGGVSTNWR 314
Cdd:pfam07690 138 PLL-GGLLASLFGWRA-----------------------------AFL---ILAILSLLAAVLLLLPRPPPESKRPKPAE 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  315 NSKIIGPFVLGFVLVPGFIYWesrlalvpfapfkllkdrgvwapLGIMFFICFVYQMAAGYLYTILVVAvDESASSATRI 394
Cdd:pfam07690 185 EARLSLIVAWKALLRDPVLWL-----------------------LLALLLFGFAFFGLLTYLPLYQEVL-GLSALLAGLL 240

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  395 INLYSFVTAVVAPFLGLIVTRSSRLKSYIIFGGSLYFITMGLFYRyrSGQDADGGIIAGMVIWGLSSCLFDYPTIVSIQS 474
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLL--SLTLSSLWLLLALLLLGFGFGLVFPALNALVSD 318

                         410       420
                  ....*....|....*....|....*.
gi 330443580  475 VTSHENMATVTALNYTVFRIGGAVAA 500
Cdd:pfam07690 319 LAPKEERGTASGLYNTAGSLGGALGP 344
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
69-499 2.70e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 56.14  E-value: 2.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  69 KAIFLFSAFICTFAYGLDSSIRGTYMTYAMNSYSA-HSLISTVSVIVLMISAVSQVIFGGLSDIFGRLTLFLVSIVLYIV 147
Cdd:COG2814    8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGAsPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 148 GTIIQSQAYDVQRYAAGAVFyyVGLVGVMLQVVLMlsdnsslkwrlfytlipswpSIITTWVSGSVVEAANPLENWSWNI 227
Cdd:COG2814   88 GSLLCALAPSLWLLLAARFL--QGLGAGALFPAAL--------------------ALIADLVPPERRGRALGLLGAGLGL 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 228 AMwaFIFPLcciplilcmlhmrwkvrndvewkelqdeksyyqthgLVQMLVQLF-WKldvvGVLLFTAGVGCILvpltla 306
Cdd:COG2814  146 GP--ALGPL------------------------------------LGGLLADLFgWR----WVFLVNAVLALLA------ 177

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 307 ggvstnwrnskiigpFVLGFVLVPGFIYWESRLALVPFapFKLLKDRGVWAPLGIMFFICFVYQMAAGYLYTILVVAVDE 386
Cdd:COG2814  178 ---------------LLLLLRLLPESRPAARARLRGSL--RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 387 SASSATRIINLYSFVTAVVAPFLGLIVTRSSRLKSyIIFGGSLYFITMGLFYRYRSGqdadGGIIAGMVIWGLSSCLFDY 466
Cdd:COG2814  241 SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRL-LLIGLLLLALGLLLLALAGSL----WLLLLALFLLGFGFGLLFP 315

                        410       420       430
                 ....*....|....*....|....*....|...
gi 330443580 467 PTIVSIQSVTSHENMATVTALNYTVFRIGGAVA 499
Cdd:COG2814  316 LLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
287-512 1.69e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 54.14  E-value: 1.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 287 VGVLLFTAGVGcILVPLtLAGGVSTNWRNSKII-GPFVLGFVLVPGFIYWESRLALVPFAPFK-----LLKDRGVWAPLG 360
Cdd:COG2211  158 LGGLLASVLPP-PLVAA-FGGDAALGYRLTALIfAVLGLLAFLLTFFGTKERPVPEEEKVSLKeslkaLLKNRPFLLLLL 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 361 IMFFICFVYQMAAGYLYTILVVAVDESASSATRIINLYSFVTAVVAPFLGLIVTRSSRLKSYIIfGGSLYFITMGLFYRY 440
Cdd:COG2211  236 AYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFII-GLLLAALGLLLLFFL 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 441 RSGQDAdgGIIAGMVIWGLSScLFDYPTIVSIQS--------VTSHENMATVTALNYTVFRIGGAVAAAISGAIWTQSLY 512
Cdd:COG2211  315 GPGNLW--LLLVLAALAGIGL-GAILVLPWAMLAdvvdydewKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGY 391
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 287-508 1.63e-06

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 50.65  E-value: 1.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 287 VGVLLFTAGVGcILVPLTLAGGVSTN--WRnskiiGPFVLGFVLVPGFIywesrlALVPFAPFKLLKDRGVWAPLGIMFF 364
Cdd:cd17504  121 QGILSATFGIG-AGIGLPLGGWIVQHlgWR-----WIFWTAAPVAVLLA------ALVPLIDLRLLRRRNVLLANITALL 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 365 ICFVYQMA-------------AGYLYTILVVAVdesassatrIINLYSFVTAVVAPFLGLIVTR-SSRLKSYIIFGGSLY 430
Cdd:cd17504  189 AGFGMFMVfqllpqllqlptpTGFGLGITEAGL---------LLLPGALVMLIAGPLAGRLIARvGPRRVLLIGLVISAV 259

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 330443580 431 FITMGLFYRYRSGQDADGGIIAGMviwGLSSCLFDYPTIVsIQSVtSHENMATVTALNYTVFRIGGAVAAAISGAIWT 508
Cdd:cd17504  260 GLLLLALLHSSLWALVVALLLIGI---GLGLAFASLPNIV-VESV-PPDRTGIATGMNTVLRTIGSAIGPAIAGAILT 332
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 342-502 1.81e-06

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 50.25  E-value: 1.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 342 VPFAPFKLLKDRGVWAPLGIMFFICFVYQMAAGYLYTILVVAVDESASSATRIINLYSFVTAVVAPFLGLIVTRSSRLKS 421
Cdd:cd17502  156 LPIGGLALALLRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKP 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 422 YIIFGGSLYFITMGLFYRYRSGqDADGGIIAGMVIWGLSSCLFDYPTIVSIQSVTSHENMATVTALNYTVFRIGGAVAAA 501
Cdd:cd17502  236 LIVIGTILMSVGAGLLTTLTLD-TSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVA 314


                 .
gi 330443580 502 I 502
Cdd:cd17502  315 I 315
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 77-151 3.13e-06

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 49.48  E-value: 3.13e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 330443580  77 FICTFAYGLDSSIRGTYMTYAMNSYSAHSLISTVSVIVLMISAVSQVIFGGLSDIFGRLTLFLVSIVLYIVGTII 151
Cdd:cd17502    2 MLALFLAALDQTIVATALPTIVAEFGGLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLL 76
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 73-365 1.53e-05

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 47.11  E-value: 1.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  73 LFSAFICTFAYGLDSSIRGTYMTYAMNSYSA-HSLISTVSVIVLMISAVSQVIFGGLSDIFGRLTLFLVSIVLYIVGTII 151
Cdd:COG0477   16 LLALALGTFLEGLDFTIVNVALPSIAADLGAsSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 152 QSQAYDVQRYAAGAVFYYVGLVGVMLQVVLMLSDNSSLKWRLFYTlipSWPSIITT--WVSGSVVEAAnPLENWSWNiam 229
Cdd:COG0477   96 CGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRAL---GLWGAAIGlgLALGPLLGGL-LVAALGWR--- 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 230 WAFIFplcCIPLILCMLHMRWKVRNDVEWkelqdeksYYQTHGLVQMLVQLFWKLDVVGVLLFTAGVGCILVPLTLAGGV 309
Cdd:COG0477  169 WIFLI---NAPLGLLALVLRLRLPESRGL--------LLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGA 237

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 330443580 310 STNWRNSKIIGPFVLGFVLVPGFIYWESRLALVPFAPFKLLKDRGVWAPLGIMFFI 365
Cdd:COG0477  238 ALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLAL 293
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
353-506 1.59e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 47.28  E-value: 1.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 353 RGVWAPLGIMFFICFVYQMAAGYLYTILVVAVDE---SASSATRIINLYSFVTAVVAPFLGLIVTRSSRlKSYIIFGGSL 429
Cdd:COG2814    6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADlgaSPAQAGLVVTAYLLGAALGAPLAGRLADRFGR-RRVLLLGLLL 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 330443580 430 YFITMGLFYRYRSgqdaDGGIIAGMVIWGLSSCLFdYPTIVS-IQSVTSHENMATVTALNYTVFRIGGAVAAAISGAI 506
Cdd:COG2814   85 FALGSLLCALAPS----LWLLLAARFLQGLGAGAL-FPAALAlIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL 157
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 362-512 2.14e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.04  E-value: 2.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 362 MFFICFVYQMAAGYLYTILVVAVDESASSATRIINL---YSFVTAVVAPFLGLIVTRSSRlKSYIIFGGSLYFITMGLFY 438
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLfalFSLGYALLQPLAGLLADRFGR-RPVLLLGLLLFALGALLFA 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 330443580 439 RYRSGqdadGGIIAGMVIWGLSSCLFDYPTIVSIQSVTSHENMATVTALNYTVFRIGGAVAAAISGAIWTQSLY 512
Cdd:cd06174   80 FAPSF----WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF 149
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 70-159 5.09e-05

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 46.03  E-value: 5.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  70 AIFLFSAFICTFAygldSSIRGTYMTYAMNSYSAHSLISTVSVIVLMIS-AVSQVIFGGLSDIFGRLTLFLVSIVLYIVG 148
Cdd:cd17323    2 FIISFLTFVVTFG----SSIYSPALPQIAEDFHVSEEVANLGVSLFVLGfGLGPLIWAPLSELYGRRPVYLVSLFIFVIF 77

                         90
                 ....*....|.
gi 330443580 149 TIIQSQAYDVQ 159
Cdd:cd17323   78 QIGCALAPNIA 88
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
355-506 5.54e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 45.63  E-value: 5.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 355 VWAPLGIMFFICFVYQMAAGYLYTILVVAVDESASSATRIINLYSFVTAVVAPFLGLIVTR-SSRLKSYIIFGGSLYFIT 433
Cdd:COG2271  182 FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRlGRRRKLVLAIGLLLAALA 261

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 330443580 434 MGLFYRYrsgqDADGGIIAGMVIWGLSSCLFDYPTIVSIQSVTSHENMATVTALNYTVFRIGGAVAAAISGAI 506
Cdd:COG2271  262 LLLLALL----PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYL 330
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 76-243 7.57e-05

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 45.26  E-value: 7.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  76 AFICTFAYGLDSSIRGTYMTY---AMNSYSAHSLISTVSVIVLMISAVSQVIFGGLSDIFGRLTLFLVSIVLYIVGTIIQ 152
Cdd:cd17315    2 AALGGLLFGYDLGVINGALLYiakDLGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 153 SQAYDVQRYAAGAVFyyVGL-VGVMLQVV-LMLSDNSSLKWR--------LFYTLipswpSIITTWVSGSVVEAANPleN 222
Cdd:cd17315   82 ALAPNVWVLIVGRFL--LGLgVGLASVLVpLYISEIAPAKIRgalgtlnqLMITF-----GILLAYLLGLALSLSPP--G 152

                        170       180
                 ....*....|....*....|.
gi 330443580 223 WswniamWAFIFPLCCIPLIL 243
Cdd:cd17315  153 W------WRLMFALAAVPALL 167
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 318-574 8.83e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 45.24  E-value: 8.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 318 IIGPFVLGFVLvpGFIYWESRLAL-VPFAPFKLLKDRGVWAPLGIMFFICFVYQMAAGYLYTILVVAVDESASSATRIIN 396
Cdd:cd17321  134 ALGPLLGGLLL--ELFGWRWIFLInVPIGLVALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALL 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 397 LYSFVTAVVAPFLGLIVTR-SSRLksyIIFGGSLyFITMGLFYRYRSGQDAD-GGIIAGMVIWGLSSCLFDYPTIVSIQS 474
Cdd:cd17321  212 PLALAMLVAAPLAGRLADRfGPRL---VLVAGLL-LTAVGLLLLALLGADSSvWLLLPGLVLLGLGLGLFATPLTNAALS 287

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 475 VTSHENMATVTALNYTVFRIGGAVAAAISGAIwtqslypkllhymgdadlATAAYGSPLTFILSNPWGTPVRSAMVEAYR 554
Cdd:cd17321  288 SVPKEKAGAASGILNTARQLGGALGVALLGAL------------------LTAGLSANLGDSGVAALLSAAAAAFAAGFH 349

                        250       260
                 ....*....|....*....|
gi 330443580 555 HVQKYEVIVALVFSAPMFLL 574
Cdd:cd17321  350 LAFLVAAALALLAALLALLL 369
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 286-509 1.13e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 44.85  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 286 VVGVLLFTAGVGCIL-VPLTLAGGVSTNWRNS-KIIGpfVLGFVLVPGFIYW------ESRLALVPFA-PFKLLKDRGVW 356
Cdd:cd17324  124 AIGLVFSGLTLGLVLgRPLGGLLGQLLGWRAAfLAIA--VLALLAALLLWRLlpslppKKPGSLGLLSsLLLLLRNPRLR 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 357 APLGIMFFICFVYQMAAGYLYTILVVAVDESASSATRIINLYSFVTAVVAPFLGLIVTRSSRLKSYIIFGG---SLYFIT 433
Cdd:cd17324  202 LAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLlaaALLLLT 281

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 330443580 434 MGLFYryrsgqdaDGGIIAGMVIWGLSSCLFdYPTIVSIQSVTSHENMATVTALNYTVFRIGGAVAAAISGAIWTQ 509
Cdd:cd17324  282 LLGPS--------PLLLLVGLVLWGLGFFAA-HSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDH 348
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
345-506 1.35e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 44.49  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 345 APFKLLKDRGVWApLGIMFFICF-VYQMAAGYLYTILVVAVDESASSATRIINLYSFVTAVVAPFLGLIVTRSSRLKSYI 423
Cdd:COG2223  197 DQLEALRDPRFWL-LSLLYFGTFgSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLL 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 424 IFGGSLYFITMGLFYryrsGQDADGGIIAGMVIWGLSSCLFDYPTIVSIQSVTSHENMATVTALNYTVFRIGGAVAAAIS 503
Cdd:COG2223  276 IVFALMALGLLLLAL----ALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLF 351


                 ...
gi 330443580 504 GAI 506
Cdd:COG2223  352 GAL 354
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
71-185 2.31e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 44.12  E-value: 2.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  71 IFLFSAFICTFAYGLDSSIRGTYMTYAMNSysAHSLISTVSVIVLMISAVSQVIFGGLSDIFGRLTLFLVSIVLYIVGTI 150
Cdd:COG2211  232 LLLLAYLLFFLALALVAALLLYYFKYVLGL--SAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLL 309

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 330443580 151 IQ--SQAYDVQRYAAGAVFYYVGLVGVMLQVVLMLSD 185
Cdd:COG2211  310 LLffLGPGNLWLLLVLAALAGIGLGAILVLPWAMLAD 346
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
295-506 2.32e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 43.69  E-value: 2.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 295 GVGCILVPL----TLAGGVSTNWRNSKIIgpfVLGFVLVPGFIYWESRLALVPF----------APFKLLKDRGVWAPLG 360
Cdd:COG0738  141 SLGALLGPLlgglLILLGLSLSWHLPYLI---LAVLLLLLALLFLRSKLPEIEEeeeeaagsaaSLKSLLKNPRLLLGGL 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 361 IMFFICFVYQMAAGYLYTILVVAVDESASSATRIINLYsFVTAVVAPFLGLIVTRSSRLKSYIIFGGSLYFITMGLFYRy 440
Cdd:COG0738  218 AIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLF-WGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALL- 295

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 330443580 441 rsgqdADGGIIA--GMVIWGLSSCLFdYPTIVSIQSVTSHENMATVTALNYTVFRIGGAVAAAISGAI 506
Cdd:COG0738  296 -----APGPWLAliGLALVGLGLSLM-FPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFL 357
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 123-250 2.33e-04

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 43.72  E-value: 2.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 123 VIFGGLSDIFGRLTLFLVSIVLYIVGTIIQSQAYDVQRYAAGAVFYYVGLVGVMLQVVLMLSDNSSLKWRlfytlipSWP 202
Cdd:cd17317   43 LLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYR-------SFV 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 330443580 203 SIITT--WVSGSVVEAAnplenWSWNIAMWAFIFPLCCIPLILCMLHMRW 250
Cdd:cd17317  116 GILFGlfWALGYMLLAL-----LAYLIRDWRWLQLAISLPGLLFLLLLWW 160
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 320-507 3.45e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 43.33  E-value: 3.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 320 GPFVLGFVLVP-GFIYW-----------ESRLALVPFAPFKLLKDRGVWAPLGIMFFICFVYQMAAGYLYTILVVAVDES 387
Cdd:cd17474  153 YPFFLLAALIPvAFLAIlfllpepkekaKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGIS 232

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 388 ASSATRIINLYSFVTAVVAPFLGLIVTRSSRLKSYIIFGGSLYFITMGLFyryrSGQDADGGIIAGMVIWGLSSCLFDYP 467
Cdd:cd17474  233 PIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLL----GFVPSLALLLIAIVLFGLGLGLNLPL 308

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 330443580 468 TIVSIQSVTSHENMATVTALNYTVFRIGGAVAAAISGAIW 507
Cdd:cd17474  309 LTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLL 348
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 94-192 9.65e-04

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 41.88  E-value: 9.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  94 MTYAMNSYSAHSLIST-VSVIVLMISAVSQVIFGGLSDIFGRLTLFLVSIVLYIVGTIIQSQAYDVQRYAA-GAVFYYVG 171
Cdd:cd17364   27 RLYYGGKGSLPSGVSGlVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTPLGVmGWLIFFRF 106

                         90       100
                 ....*....|....*....|....*..
gi 330443580 172 LVGV------MLQVVLMlSDNSSLKWR 192
Cdd:cd17364  107 LLGIgiggdyPLSATIM-SEYANKKRR 132
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
73-429 9.94e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 41.78  E-value: 9.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  73 LFSAFICTFAYGLDSSIRGTYMTYAMNSYSA-HSLISTVSVIVLMISAVSQVIFGGLSDIFGRLTLFLVSIVLYIVGTII 151
Cdd:COG2271   12 LALLFLAYFLNYLDRSNLSVAAPPLQADLGLsAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 152 QSQAYDVQRYAAGAVFYYVGLVGVMLQVVLMLSDNSSLKWR----LFYTLIPSWPSIITTWVSGSVVEAanplenWSWNI 227
Cdd:COG2271   92 FGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERgralGIFNAGGPLGGALAPPLLGWLLAA------FGWRA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 228 AMWAFIFP---------LCCIPLILCMLHMRWKVrndvewkelqdeksyyQTHgLVQMLVQLFwKLDVVGVLLFTAGVGC 298
Cdd:COG2271  166 AFLILGLPglllallrfWLLALAYFLVYFALYGF----------------LTW-LPTYLVEVR-GLSLAQAGLLLSLPFL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 299 ILVPLTLAGGVSTNWRNSKIIGPFVLGFVLVPGFiywesrLALVPFAPfkllkdrGVWAPLGIMFFICFVYQMAAGYLYT 378
Cdd:COG2271  228 AGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALA------LLLLALLP-------SPALAIALLFLAGFGLGGAFGLLWA 294

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 330443580 379 ILVVAVD-ESASSATRIINLYSFVTAVVAPFL-GLIVTRSSRLKSYIIFGGSL 429
Cdd:COG2271  295 LAAELFPkKARGTASGLVNTFGFLGGALGPLLvGYLLDATGYQAAFLLLAALA 347
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 347-508 1.49e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.41  E-value: 1.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 347 FKLLKDRGVWAPLGIMFFICFVYQMAAGYLYTILVVAVDESASSATRIINLYSFVTAVVAPFLGLIVTRSSRlKSYIIFG 426
Cdd:cd17325  193 RLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGR-KPLILIG 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 427 GSLYFITMGLFyryrSGQDADGGIIAGMVIWGLSSCLFDYPTIVSIQSVTSHENMATVTALNYTVFRIGGAVAAAISGAI 506
Cdd:cd17325  272 LLLSAVALLLL----PLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFL 347


                 ..
gi 330443580 507 WT 508
Cdd:cd17325  348 YD 349
MFS_1 pfam07690
Major Facilitator Superfamily;
359-506 1.63e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.86  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  359 LGIMFFICFVYQMAAGYLYTILVVAVDESASSATRIINLYSFVTAVVAPFLGLIVTRSSRLKSYIIFGGSLYFITMGLFY 438
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 330443580  439 RYRSGQdadggIIAGMVIWGLSSCLFDYPTIVSIQSVTSHENMATVTALNYTVFRIGGAVAAAISGAI 506
Cdd:pfam07690  82 ASSLWL-----LLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL 144
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 105-151 2.00e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 41.00  E-value: 2.00e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 330443580 105 SLISTVSVIVLMISAVSQVIFGGLSDIFGRLTLFLVSIVLYIVGTII 151
Cdd:cd17321   31 SQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLL 77
Sugar_tr pfam00083
Sugar (and other) transporter;
72-152 2.13e-03

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 40.72  E-value: 2.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580   72 FLF---SAFICTFAYGLDSSIRGTYMTYAMNSYSAHSLISTVSVIVLMISAVSQVIFGGLSDIFGRLTLFLVSIVLYIVG 148
Cdd:pfam00083  10 FLFgydTGVIGAFLTLIDFFKNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIG 89


                  ....
gi 330443580  149 TIIQ 152
Cdd:pfam00083  90 AVLQ 93
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 339-509 2.13e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 40.64  E-value: 2.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 339 LALVPFAPFKLLKDRGVWAPLGIMFFICFVYqMAAGYLYTI-LVVAVDESASSATRIINLYSFVTAVVAPFLGLIVTRSS 417
Cdd:cd17503  164 LLLAPLLDLRLFKDRNFTLGLLLSFLLGLGL-FGAMFLLPLyLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFG 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 418 rLKSYIIFGGSLYFITMGLFYRYrSGQDADGGIIAGMVIWGLSSCLFDYPTIVSIQSVTSHENMATVTALNYTVFRIGGA 497
Cdd:cd17503  243 -PRLLLLAGLLLLALGTLLLAFL-TPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGS 320

                        170
                 ....*....|..
gi 330443580 498 VAAAISGAIWTQ 509
Cdd:cd17503  321 IGTALLATLLTN 332
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 323-508 2.56e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 40.60  E-value: 2.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 323 VLGFVLVPGFIywesrlALVPFAPFKLLKDR----------GVWAPLGIMF--FICFVYQMAAGYL-YTILVVAVDESAS 389
Cdd:cd17370  158 IFLLAAIPALL------ALLILLFVVKEYPRppklrkkskkTSLKKLPKAFwlYLLAVALFALGNFsFAFLILRAQELGL 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 390 SATRIINLY---SFVTAVVAPFLGLIVTRSSRlKSYIIFGGSLYFITMGLFyryrSGQDADGGIIAGMVIWGLSSCLFD- 465
Cdd:cd17370  232 SAALIPLLYalfNLVYALAAYPAGRLSDRIGR-KKLLILGYLSLALAYLGF----ALGSSLWLLLLGFILWGLYMGAQEs 306

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 330443580 466 -YPTIVSiqSVTSHENMATVTALNYTVFRIGGAVAAAISGAIWT 508
Cdd:cd17370  307 iERAAVA--DLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWD 348
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 71-159 2.98e-03

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 40.31  E-value: 2.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580  71 IFLFSAFICTFAYGLDS-SIRGTYMT------YAMNSYSAHSLISTVSVIVLMISAVSqvIFGGL-----SDIFGRLTLF 138
Cdd:cd17356    1 LLCAFVSLGGFLFGYDTgSISGILNMksfqkyFADNTGTYYPSSSRQGLIVSIVNLGS--FFGALissflSDRIGRKKSI 78

                         90       100
                 ....*....|....*....|.
gi 330443580 139 LVSIVLYIVGTIIQSQAYDVQ 159
Cdd:cd17356   79 QIGCVIYIIGAIIQVAAIGKW 99
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
355-506 4.13e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 39.85  E-value: 4.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443580 355 VWAPLGIMFFICFVYQMAAGYLYTILVVAVDESASSATRIINLYSFVTAVVAPFLGLIVTRSSRLKSYII--FGGSLYFI 432
Cdd:COG2271   11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIglLLWGLATL 90

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 330443580 433 TMGLFYRYrsgqdadGGIIAGMVIWGLSSCLFDYPTIVSIQSVTSHENMATVTALNYTVFRIGGAVAAAISGAI 506
Cdd:COG2271   91 LFGFATSF-------WQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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