|
Name |
Accession |
Description |
Interval |
E-value |
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
20-372 |
1.39e-131 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 381.16 E-value: 1.39e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 20 DVAPPINVSTTFRYDDDDLIPWTerenLDFMEKKPVYSRLAHPNSTRLESIFSEILDG-YAVIYSSGLAAFYAAMVHYNP 98
Cdd:cd00614 2 AVAPPIYQTSTFVFPSPAEAADL----FALREGGYIYSRIGNPTVDALEKKLAALEGGeAALAFSSGMAAISTVLLALLK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 99 K--KIFIG-QSYHGVRAIANILTRNYGIEQHP-----LEDIEKCASEG-DIVHLESPVNPYGTSSDIESLARRAHAKGAL 169
Cdd:cd00614 78 AgdHVVASdDLYGGTYRLFERLLPKLGIEVTFvdpddPEALEAAIKPEtKLVYVESPTNPTLKVVDIEAIAELAHEHGAL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 170 LIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKEEATSRQLKDDRIYLGTNVANLESFMLLRSLRTYE 249
Cdd:cd00614 158 LVVDNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 250 MRITKQSENATKLVRFLSDHqsefDKVLKTIY--HSSLQTEEFVKKQLvGGYGPVFAITLY-TKEQCKQLPLKLKYFHHA 326
Cdd:cd00614 238 LRMERHSENALKVAEFLEKH----PKVERVYYpgLPSHPQHELAKKQM-SGYGGVFSFELKgGLEAAKKFLNALKLFSLA 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 6321904 327 TSLGGIESLVEWRAMTDP-----------YIDQTLIRVSVGCESANDLIKDLASALK 372
Cdd:cd00614 313 VSLGGVESLVEHPASMTHsqlppeeraaaGITPGLVRLSVGIEDVEDLIADLEQALK 369
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
3-374 |
2.28e-87 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 269.23 E-value: 2.28e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 3 DLSTALIH-GDDKDNRVTDVAPPINVSTTFRYDDDDlipwTERENLDFMEKKPVYSRLAHPNSTRLESIFSEiLDG--YA 79
Cdd:COG0626 2 GPATRAVHaGRDPDPQTGAVSPPIYLTSTFVFPSAE----ALAARFAGEEGGYIYSRYGNPTRRALEEALAA-LEGgeAA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 80 VIYSSGLAAFYAAMVHY-NP-KKIFIGQS-YHGVRAIANILTRNYGIE-----QHPLEDIEKCASEG-DIVHLESPVNPY 150
Cdd:COG0626 77 LAFASGMAAISAVLLALlKAgDHVVASDDlYGGTRRLLDKVLARFGIEvtfvdPTDLAAVEAAIRPNtKLVFLETPSNPT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 151 GTSSDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKEEATSRQLKDDRIYLG 230
Cdd:COG0626 157 LEVVDIAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAERLRFLQNALG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 231 TNVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHqsefDKVLKtIYHSSLQTE---EFVKKQLvGGYGPVFAITL 307
Cdd:COG0626 237 AVLSPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAH----PAVAR-VYYPGLPSHpghELAKRQM-SGFGGMLSFEL 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6321904 308 Y-TKEQCKQLPLKLKYFHHATSLGGIESLVEWRAMT-----------DPYIDQTLIRVSVGCESANDLIKDLASALKEL 374
Cdd:COG0626 311 KgGREAARRFLDALKLFTLAVSLGGVESLITHPATMthrslppeeraALGITDGLVRLSVGLEDVDDLIADLEQALAAL 389
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
5-372 |
2.07e-68 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 220.18 E-value: 2.07e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 5 STALIHGDDKDNRVTD-VAPPINVSTTFRYDdddlipwTERENLDFmekkpVYSRLAHPNSTRLESIFSEILDG-YAVIY 82
Cdd:pfam01053 1 DTLAVHAGQRPDPQTGaVSVPIYLTSTYVFD-------FAGEEGGY-----DYSRSGNPTRDVLEERIAALEGGaAALAF 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 83 SSGLAAFYAA---MVHYNPKKIFIGQSYHGVRAIANILTRNYGIEQHP-----LEDIEK-CASEGDIVHLESPVNPYGTS 153
Cdd:pfam01053 69 SSGMAAITAAilaLLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFvdtsdPEDLEAaIKPNTKAVYLETPTNPLLKV 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 154 SDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKEEATSRQLKDDRIYLGTNV 233
Cdd:pfam01053 149 VDIEAIAKLAKKHGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNATGAVL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 234 ANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHqsefDKVlKTIYHSSLQTE---EFVKKQLVGGYGpvfAITLYTK 310
Cdd:pfam01053 229 SPFDAWLLLRGLKTLGLRMEQHQENAQKVAEFLESH----PKV-EKVYYPGLPSHpghELAKRQMKGFGG---MLSFELK 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6321904 311 ---EQCKQLPLKLKYFHHATSLGGIESLVEWRA-MT----------DPYIDQTLIRVSVGCESANDLIKDLASALK 372
Cdd:pfam01053 301 gglEAAKKFLDNLKLFSLAVSLGGVESLISHPAtMThasippeereAAGITDDLIRLSVGIEDVDDLIADLKQALE 376
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
20-377 |
1.19e-55 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 187.64 E-value: 1.19e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 20 DVAPPINVSTTFRYDDDDliPWTEREnldfMEKKP--VYSRLAHPNSTRLESIFsEILDGY--AVIYSSGLAAFYAAMVH 95
Cdd:PRK08249 26 ATQVPVVLSVAYGYDDID--EWYDVA----LGKKPghIYSRNTNPTVQAFEEKV-RILEGAeaATAFSTGMAAISNTLYT 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 96 Y--NPKKIF-IGQSYHGVRAIANILTRNYGI-----EQHPLEDIEKCASEG-DIVHLESPVNPYGTSSDIESLARRAHAK 166
Cdd:PRK08249 99 FlkPGDRVVsIKDTYGGTNKIFTEFLPRMGVdvtlcETGDHEQIEAEIAKGcDLLYLETPTNPTLKIVDIERLAAAAKKV 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 167 GALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKEEATSRQlkddRIYLGTNVANLESF---MLLR 243
Cdd:PRK08249 179 GALVVVDNTFATPINQNPLALGADLVIHSATKFLSGHADALGGVVCGSKELMEQV----YHYREINGATMDPMsayLILR 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 244 SLRTYEMRITKQSENATKLVRFLSDHqsefDKVlKTIYHSSLQT---EEFVKKQLvGGYGPVFAITLYTK-EQCKQLPLK 319
Cdd:PRK08249 255 GMKTLKLRVRQQQESAMALAKYLQTH----PKV-EAVYYPGLEThpnHEIAKAQM-RGFGGILSFVLKGGmDTVKRLLPK 328
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6321904 320 LKYFHHATSLGGIESLV--------------EWRAMTdpyIDQTLIRVSVGCESANDLIKDLASALKELQDA 377
Cdd:PRK08249 329 LRYAHRAANLGAVETIYgparttshventleERAALG---IPEGLVRISVGIEDTEDLIADLEQAFAHLESE 397
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
6-372 |
2.71e-55 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 186.08 E-value: 2.71e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 6 TALIHGD-DKDNRVTDVAPPI-NVSTtfrYDDDDLIPWTEREnldfmekkpvYSRLAHPNSTRLESIFSEILDGYA-VIY 82
Cdd:PRK07671 5 TKLIHGGiIGDPSTGAVSVPIyQVST---YKQEAVGKHQGYE----------YSRTGNPTRAALEELIAVLEGGHAgFAF 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 83 SSGLAAFYAAMVHYNPKK--IFIGQSYHGV-RAIANILTRnYGIEQ-----HPLEDIEKCAS-EGDIVHLESPVNPYGTS 153
Cdd:PRK07671 72 GSGMAAITAVMMLFSSGDhvILTDDVYGGTyRVMTKVLNR-FGIEHtfvdtSNLEEVEEAIRpNTKAIYVETPTNPLLKI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 154 SDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKeeatSRQLKDDRIYLGTNV 233
Cdd:PRK07671 151 TDIKKISTIAKEKGLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVN----SPELAEDLHFVQNST 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 234 ANL----ESFMLLRSLRTYEMRITKQSENATKLVRFLSDHqsefdKVLKTIYHSSLQTE---EFVKKQlVGGYGPVFAIT 306
Cdd:PRK07671 227 GGIlgpqDSWLLLRGLKTLGIRMEEHETNSRAIAEFLNNH-----PAVNKVYYPGLPSHpnhELAKEQ-ANGFGGMISFD 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6321904 307 LYTKEQCKQLPLKLKYFHHATSLGGIESLVEWRA-MTDPYIDQ----------TLIRVSVGCESANDLIKDLASALK 372
Cdd:PRK07671 301 VGSEETANKVLERLQYFTLAESLGAVESLISIPSqMTHASIPAdrrkelgitdGLIRISVGIEDGEDLIEDLAQALA 377
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
3-371 |
3.20e-53 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 181.00 E-value: 3.20e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 3 DLSTALIH-GDDKDNRVTDVAPPINVSTTFRYDDddliPWTERENLDfmekkpvYSRLAHPNSTRLESIFSEILDG-YAV 80
Cdd:PRK07811 12 GFATRAIHaGYEPDPATGAVNPPIYASSTFAQDG----VGGLRGGYE-------YARTGNPTRTALEEQLAALEGGaYGR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 81 IYSSGLAAFYAAM-VHYNP-KKIFIGQSYHG--VRAIANILTRnYGIEQHP--LEDIEKC----ASEGDIVHLESPVNPY 150
Cdd:PRK07811 81 AFSSGMAATDCLLrAVLRPgDHIVIPNDAYGgtFRLIDKVFTR-WGVEYTPvdLSDLDAVraaiTPRTKLIWVETPTNPL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 151 GTSSDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKEEATsrqlkDDRIYLG 230
Cdd:PRK07811 160 LSITDIAALAELAHDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNDEEL-----DEAFAFL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 231 TNVAN-----LESFMLLRSLRTYEMRITKQSENATKLVRFLSDHQSefdkvLKTIYHSSLQTE---EFVKKQLvGGYGPV 302
Cdd:PRK07811 235 QNGAGavpgpFDAYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPE-----VSTVLYPGLPSHpghEVAARQM-RGFGGM 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6321904 303 FAITLYTKEQ-CKQLPLKLKYFHHATSLGGIESLVEW-RAMTDPYIDQT-------LIRVSVGCESANDLIKDLASAL 371
Cdd:PRK07811 309 VSVRLAGGEEaARDFCARTKVFTLAESLGGVESLIEHpSAMTHASTAGSqlevpddLVRLSVGIEDVADLLADLEQAL 386
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
4-373 |
1.89e-52 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 178.48 E-value: 1.89e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 4 LSTALIHGDDKDNRVTDVAPPINVSTTFRYDDDDlipwtERENLDfmekkpvYSRLAHPNSTRLESIFSEILDGYAVI-Y 82
Cdd:TIGR01329 1 LSTLLVNTDNKNDPYDASSMPIYQTATFKQPLAI-----ENGPYD-------YTRSGNPTRTALESLLAKLDKADRAFaF 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 83 SSGLAAFYAAMVHYNPKKIFIGQS--YHGVRAIANILTRNYGIEQH--PLEDIEKCAS----EGDIVHLESPVNPYGTSS 154
Cdd:TIGR01329 69 SSGMAALDVITRLLNNGDEIIAGDdlYGGTDRLLTQVVPRSGVVVVhvDTTDLDKVKAalgpKTKLVLLESPTNPLQKIV 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 155 DIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKEEATSrqlkdDRIYL----- 229
Cdd:TIGR01329 149 DIRKISEMAHAQNALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAVKGEEIA-----KKVYFlqnst 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 230 GTNVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHQSefdkvLKTIYHSSLQTEE--FVKKQLVGGYGPVFAITL 307
Cdd:TIGR01329 224 GSGLAPFDCWLLLRGIKTLAIRIEKQQENARAIAMFLSTHPR-----VKKVRYAGLPSHPgfHLHFSQAKGAGSVLSFET 298
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6321904 308 YTKEQCKQLPLKLKYFHHATSLGGIESLVEWRA-MTDPYID----------QTLIRVSVGCESANDLIKDLASALKE 373
Cdd:TIGR01329 299 GSVALSKRLVEATKLFSITVSFGSVNSLISMPCfMSHASIPaevreerglpEDLVRLSVGIEDVDDLISDLDIAFVT 375
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
4-372 |
6.21e-51 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 176.76 E-value: 6.21e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 4 LSTALIHGDDKDNRVTDVAPPINVSTTFRYDDDdlipwTERENLDfmekkpvYSRLAHPNSTRLESIFSEiLD--GYAVI 81
Cdd:PLN02509 87 VSTLLVNLDNKFDPFDAMSTPLYQTATFKQPSA-----IENGPYD-------YTRSGNPTRDALESLLAK-LDkaDRAFC 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 82 YSSGLAAFyAAMVHY--NPKKIFIGQSYHGV--RAIANILTRNyGI--EQHPLEDIEKCAS----EGDIVHLESPVNPYG 151
Cdd:PLN02509 154 FTSGMAAL-SAVTHLikNGEEIVAGDDVYGGsdRLLSQVVPRS-GVvvKRVNTTNLDEVAAaigpQTKLVWLESPTNPRQ 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 152 TSSDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKEEATSRQLKDDRIYLGT 231
Cdd:PLN02509 232 QISDIRKIAEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGS 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 232 NVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHQSefdkvLKTIYHSSLQTE--EFVKKQLVGGYGPVFAITLYT 309
Cdd:PLN02509 312 GLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPR-----VKKVYYAGLPDHpgHHLHFSQAKGAGSVFSFITGS 386
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6321904 310 KEQCKQLPLKLKYFHHATSLGGIESLV----------------EWRAMTdpyidQTLIRVSVGCESANDLIKDLASALK 372
Cdd:PLN02509 387 VALSKHLVETTKYFSIAVSFGSVKSLIsmpcfmshasipaevrEARGLT-----EDLVRISAGIEDVDDLISDLDIAFR 460
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
4-374 |
1.42e-50 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 173.93 E-value: 1.42e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 4 LSTALIHGDDKDNRVTD-VAPPINVSTTFRyddddlipwterENLDFMEKKPVYSRLAHPNSTRLESIFSEI---LDGYA 79
Cdd:PRK06176 3 MQTKLIHGGISEDTTTGaVSVPIYQTSTYR------------QDAIGRPKGYEYSRSGNPTRFALEELIADLeggVKGFA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 80 viYSSGLAAFYAAMVHYNPKK-IFIGQSYHG--VRAIANILTRN---YGI-EQHPLEDIEKC-ASEGDIVHLESPVNPYG 151
Cdd:PRK06176 71 --FASGLAGIHAVFSLFQSGDhVLLGDDVYGgtFRLFDKVLVKNglsCTIiDTSDLSQIKKAiKPNTKALYLETPSNPLL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 152 TSSDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKEEATSRQLKDDRIYLGT 231
Cdd:PRK06176 149 KITDLAQCASVAKDHGLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 232 NVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHQSefdkvLKTIYHSSLQTE---EFVKKQLVgGYGPVFAITLY 308
Cdd:PRK06176 229 VLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPK-----VEKVYYPGLPTHpnhELAKKQMR-GFSGMLSFTLK 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6321904 309 TKEQCKQLPLKLKYFHHATSLGGIESLVEWRA-MTDPYIDQT----------LIRVSVGCESANDLIKDLASALKEL 374
Cdd:PRK06176 303 NDSEAVAFVESLKLFILGESLGGVESLVGIPAfMTHACIPKEqreaagirdgLVRLSVGIEHEQDLLEDLEQAFAKI 379
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
5-374 |
2.38e-49 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 170.84 E-value: 2.38e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 5 STALIH-GDDKDNRVTDVAPPINVSTTFRYDDddlipwTERENLDFM--EKKPVYSRLAHPNSTRLESIFSEILDGYA-V 80
Cdd:TIGR01328 5 ATRAIHaGYPPKDQFGALTPPIYQTSTFVFDS------CEQGGNRFAgqESGYIYSRLGNPTVSNLEGRIAFLEGTEAaV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 81 IYSSGLAAFYAAMVHYNP--KKIFIGQSYHG-VRAIANILTRNYGIE--QHPLEDIEKCAS----EGDIVHLESPVNPYG 151
Cdd:TIGR01328 79 ATSSGMGAIAATLLTILKagDHLISDECLYGcTFALLEHALTKFGIQvdFINMAIPEEVKAhikdNTKIVYFETPANPTM 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 152 TSSDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKEEATSR-QLKDDRIYLG 230
Cdd:TIGR01328 159 KLIDMERVCRDAHSQGVKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLICGKAELLQQiRMVGIKDMTG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 231 TNVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHQSefdkvLKTIYHSSLQTEE---FVKKQLVGGYGPVFAITL 307
Cdd:TIGR01328 239 SVISPFDAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPA-----VEKVYYPGFEDHPghdIAAKQMRMGGGMITFELK 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6321904 308 YTKEQCKQLPLKLKYFHHATSLGGIESLVEWRA-MTD-PY---------IDQTLIRVSVGCESANDLIKDLASALKEL 374
Cdd:TIGR01328 314 GGFAGAKKLLNNLKLIRLAVSLGDAETLIQHPAsMTHaVVpkeereaagITDGMIRLSVGLEDADDLIADLKQALDAL 391
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
4-374 |
7.24e-48 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 166.93 E-value: 7.24e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 4 LSTALIHGDD-KDNRVTDVAPPINVSTTFRYDDddlipwTERENLDFM--EKKPVYSRLAHPNSTRLESIFSEILDGYAV 80
Cdd:PRK06234 9 FATKAIHGGHiGDKQFGSLATPIYQTSTFIFDS------AEQGGRRFAgeESGYIYSRLGNPTSTEVENKLALLEGGEAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 81 I-YSSGLAAFYAAMV-------HYNPKKIFIGQSY----HGvraianiLTRnYGIE-----QHPLEDIEKCASEG-DIVH 142
Cdd:PRK06234 83 VvAASGMGAISSSLWsalkagdHVVASDTLYGCTFallnHG-------LTR-YGVEvtfvdTSNLEEVRNALKANtKVVY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 143 LESPVNPYGTSSDIESLARRAHA--KGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKEEATSR 220
Cdd:PRK06234 155 LETPANPTLKVTDIKAISNIAHEnnKECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFVVGKEEFINQ 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 221 ----QLKDdriYLGTNVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHQSefdkvLKTIYHSSLQT---EEFVKK 293
Cdd:PRK06234 235 vklfGIKD---MTGSVIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPA-----VEKVYYPGLESfeyYELAKK 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 294 QLvGGYGPVFAITLYTK-EQCKQLPLKLKYFHHATSLGGIESLVEWRA-MT-DPY---------IDQTLIRVSVGCESAN 361
Cdd:PRK06234 307 QM-SLPGAMISFELKGGvEEGKVVMNNVKLATLAVSLGDAETLIQHPAsMThSPYtaeerkeagISDGLVRLSVGLEDVD 385
|
410
....*....|...
gi 6321904 362 DLIKDLASALKEL 374
Cdd:PRK06234 386 DIIADLKQALDLI 398
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
11-377 |
4.27e-47 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 164.68 E-value: 4.27e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 11 GDDKDNRVTDVAPPINVSTTFRYDDDDLIPwterenldfmekKPVYSRLAHPNSTRLESIFSEILDGY-AVIYSSGLAA- 88
Cdd:PRK08861 14 GIESDSQYHAVVPPIYLSTNYGFPAFGEVP------------KYDYTRSGNPNRGLLEQTLSELESGKgAVVTNCGTSAl 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 89 --FYAAMVhyNPKKIFIG--QSYHGVRAIANilTR-NYG------IEQHPLEDIEKC-ASEGDIVHLESPVNPYGTSSDI 156
Cdd:PRK08861 82 nlWVSALL--GPDDLIVAphDCYGGTYRLFN--TRaNKGdfkvqfVDQSDAAALDAAlAKKPKLILLETPSNPLVRVVDI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 157 ESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKEEATSRQLKDDRIYLGTNVANL 236
Cdd:PRK08861 158 AELCQKAKAVGALVAVDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLITKTKEHAEELAWWGNCIGATGTPF 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 237 ESFMLLRSLRTYEMRITKQSENATKLVRFLSDHQsefdkVLKTIYHSSLQT---EEFVKKQLVgGYGPVFAITLY-TKEQ 312
Cdd:PRK08861 238 DSYMTLRGIRTLGARMRVHEESAQQILAYLQTQS-----LVGTIYHPSLPEhpgHEIAKKQQS-GFGSMLSFEFAgSFEQ 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6321904 313 CKQLPLKLKYFHHATSLGGIESLV------EWRAMTDPY-----IDQTLIRVSVGCESANDLIKDLASALKELQDA 377
Cdd:PRK08861 312 LKVFVKALALFSLAESLGGVESLIchpasmTHRAMGEEAlaeagVSQQLLRLSVGLEDAQDLIADLDQAFAKAAEA 387
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
3-378 |
4.56e-47 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 164.56 E-value: 4.56e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 3 DLSTALIHGDDKDNRVTD-VAPPINVSTTFRYDDDDlipwterenlDFmeKKPVYSRLAHPNSTRLESIFSEI---LDGY 78
Cdd:PRK08064 6 SIDTLLLHNQYKHDKQTGaVNVPIYHASTFHQFDFD----------TF--GKYDYSRSGNPTREALEDIIAELeggTKGF 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 79 AviYSSGLAAFYAAMV------HYNPKKIFIGQSYhgvRAIANILTRnYGIEQH--PLEDIEKCA----SEGDIVHLESP 146
Cdd:PRK08064 74 A--FASGMAAISTAFLllskgdHVLISEDVYGGTY---RMITEVLSR-FGIEHTfvDMTNLEEVAqnikPNTKLFYVETP 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 147 VNPYGTSSDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKEEATSRQLKDDR 226
Cdd:PRK08064 148 SNPLLKVTDIRGVVKLAKAIGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAVVKDEELAQKLYFLQ 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 227 IYLGTNVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHqsefdKVLKTIYHSSLQTE---EFVKKQLVGGyGPVF 303
Cdd:PRK08064 228 NSFGAVLGVQDCWLVLRGLKTLHVRLEHSSETANKIALYLQEH-----PKVQNVYYPGLQTHlgfDIQQSQATSA-GAVL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 304 AITLYTKEQCKQLPLKLKYFHHATSLGGIESLVEWRA-MTDPY----------IDQTLIRVSVGCESANDLIKDLASALK 372
Cdd:PRK08064 302 SFTLQSEEAVRQFVSHVKLPVFAVSLGAVESILSYPAkMSHAAmpkeerdergITDGLLRLSVGLENVDDLIADFEQALS 381
|
....*.
gi 6321904 373 ELQDAA 378
Cdd:PRK08064 382 YVEEPV 387
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
4-372 |
8.80e-47 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 163.45 E-value: 8.80e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 4 LSTALIH-GDDKDNRVTDVAPPINVSTTFRYDDddlipWTERENLDfmekkpvYSRLAHPNSTRLESIFSEILDG-YAVI 81
Cdd:PRK07269 7 INTILAQaGIKSDEATGALVTPLHFSTTYQHPE-----FGQSTGFD-------YTRTKNPTRAKLEETLAAIESAdYALA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 82 YSSGLAAFYAAMvhynpkKIF-IGQSYHGVRAIANILTR-----------NYGIEQHPLEDIEKCASEGDIVHLESPVNP 149
Cdd:PRK07269 75 TSSGMSAIVLAF------SVFpVGSKVVAVRDLYGGSFRwfnqqekegrfHFTYANTEEELIAAIEEDTDIVYIETPTNP 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 150 YGTSSDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKEEATSRQLKDDRIYL 229
Cdd:PRK07269 149 LMVEFDIEKVAKLAHAKGAKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVVTNDLELYEKLFYNLNTT 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 230 GTNVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHQSefdkvlktiyhsslqteefVKKQLVGGYGPVFAITLYT 309
Cdd:PRK07269 229 GAVLSPFDSYLLMRGLKTLSLRMERSTANAQEVVAFLKKSPA-------------------VKEVLYTGKGGMISFKVAD 289
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6321904 310 KEQCKQLPLKLKYFHHATSLGGIESLVEWRAmTDPYID------------QTLIRVSVGCESANDLIKDLASALK 372
Cdd:PRK07269 290 ETRIPHILNSLKVFTFAESLGGVESLITYPT-TQTHADipaevrhsygltDDLLRLSIGIEDARDLIADLKQALE 363
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
4-374 |
1.05e-46 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 163.86 E-value: 1.05e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 4 LSTALIH-GDDKDNRVTDVAPPINVSTTFRYDDddlipwTERENLDFMEKKP--VYSRLAHPNSTRLESIFSEILDG-YA 79
Cdd:PRK06767 6 METALIHhGYTSEEHKGSLTPPLFQTSTFTFET------AQQGEASFAGVDPsyIYSRLGNPTVKLFEERMAVLEGGeEA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 80 VIYSSGLAAFYAAMVHYNPKKIFIGQS---YHGVRAIANILTRNYGIEqHPLEDIEkcaSEGDI----------VHLESP 146
Cdd:PRK06767 80 LAFGSGMAAISATLIGFLKAGDHIICSnglYGCTYGFLEVLEEKFMIT-HSFCDME---TEADIenkirpntklIFVETP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 147 VNPYGTSSDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKEEATSRQLKDDR 226
Cdd:PRK06767 156 INPTMKLIDLKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 227 IYLGTNVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHqsefDKVlKTIYHSSLqteEFVKKQLVGGYGPV-FAI 305
Cdd:PRK06767 236 KDIGGIMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNH----DAV-EGVWYPEG---ELASRQMKRGGGVIsFSI 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 306 TlYTKEQCKQLPLKLKYFHHATSLGGIESLVEWRA-MTDPY----------IDQTLIRVSVGCESANDLIKDLASALKEL 374
Cdd:PRK06767 308 K-GGKEETQAFINDLHFITIAVSLGDTETLIQHPAtMTHAAipaelrqemgIYDNLIRLSVGLESWEDIVSDLEQALKKI 386
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
21-371 |
1.32e-46 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 164.46 E-value: 1.32e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 21 VAPPINVSTTFRYDdddlipwTERENLDFME----KKP---------VYSRLAHPNSTRLESIFSeILDGY--AVIYSSG 85
Cdd:PRK07049 36 VKPPVFLTSTFVFR-------SAEDGRDFFDyvsgRKEppagegaglVYSRFNHPNSEIVEDRLA-VYEGAesAALFSSG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 86 LAAFYAAMVHYNPKKIFIGQS---YHGVRA-IANILtRNYGIEQHPLED----------IEKCASEGDI--VHLESPVNP 149
Cdd:PRK07049 108 MSAIATTLLAFVRPGDVILHSqplYGGTETlLAKTF-RNFGVGAVGFADglseaaigaaAEAAAAKGRVslILIETPANP 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 150 YGTSSDIESLARRAHAKGA------LLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVlVVKEEATSRQLK 223
Cdd:PRK07049 187 TNSLVDVAAVRRVADAIEArqghrpIIACDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHSDLVAGA-VLGRKALIRQVR 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 224 DDRIYLGTNVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHQsefdKVLKTIYHSSLQTEEFVKKQLVG---GYG 300
Cdd:PRK07049 266 ALRSAIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHP----KVEKLHYLPFLDPDSAYGAVYKRqctGAG 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 301 PVFAITLY-TKEQCKQLPLKLKYFHHATSLGGIESLVEWRA-MTD---PY-------IDQTLIRVSVGCESANDLIKDLA 368
Cdd:PRK07049 342 STFSFDIKgGQAAAFRFLNALQIFKLAVSLGGTESLASHPAsMTHsgvPAdvrerigVLESTIRLSIGIEHPDDLIADLA 421
|
...
gi 6321904 369 SAL 371
Cdd:PRK07049 422 QAL 424
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
7-371 |
2.76e-46 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 162.38 E-value: 2.76e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 7 ALIHGDDKDNRVTDVAPPINVSTTFRYddddliPWTEREN-LDFMEKKP-VYSRLAHPNSTRLESIFSEILD-GYAVIYS 83
Cdd:PRK06434 13 AVQSGELRDPRFGNVTTPIFETSTFVY------PNSEKEAyMDSTRGMPyIYTRWGNPTVQAFEEKYAVLENaEHALSFS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 84 SGLAAFYAA---MVHYNPKKIFIGQSYHGVRAIANILTRNYGI-----EQHPLEDIEKCASEGDIVHLESPVNPYGTSSD 155
Cdd:PRK06434 87 SGMGAITSAilsLIKKGKRILSISDLYGQTFYFFNKVLKTLGIhvdyiDTDRLNSLDFDPSNYDLIYAESITNPTLKVPD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 156 IESLARRAHakGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKEEATSRQLKDDRIYLGTNVAN 235
Cdd:PRK06434 167 IKNVSSFCH--ENDVIVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNNKSIFNNLVERRKTLGSNPDP 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 236 LESFMLLRSLRTYEMRITKQSENATKLVRFLSDHqsefDKVLKTIYHSSlqteEFVKKQLvGGYGPVFAITLYTKEQCKQ 315
Cdd:PRK06434 245 IQAYLALRGLKTLGLRMEKHNKNGMELARFLRDS----KKISNVYYPDT----EIGKKVL-RGFGGMLSFELRSMEDVHK 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6321904 316 LPLKLKYFHHATSLGGIESLVEWRAMTDPY-----------IDQTLIRVSVGCESANDLIKDLASAL 371
Cdd:PRK06434 316 FIRNLEIPMVAASLGGVESLITLPVETSHSslspeererlgISDNLVRFSIGIEDIDDLIKDIENAL 382
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
7-372 |
9.33e-45 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 158.52 E-value: 9.33e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 7 ALIHGDDKDNRVTDVAPPINVSTTFRYDDddlipWTERENLDfmekkpvYSRLAHPNSTRLESIFSEILDGY-AVIYSSG 85
Cdd:PRK08045 9 AVRSGLNDDEQYGCVVPPIHLSSTYNFTG-----FNEPRAHD-------YSRRGNPTRDVVQRALAELEGGAgAVLTNTG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 86 LAAFY-AAMVHYNPKKIFI------GQSYH-----GVRAIANILTRNYGIEQHPLEDIekcASEGDIVHLESPVNPYGTS 153
Cdd:PRK08045 77 MSAIHlVTTVFLKPGDLLVaphdcyGGSYRlfdslAKRGCYRVLFVDQGDEQALRAAL---AEKPKLVLVESPSNPLLRV 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 154 SDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKEEATSRQLKDDRIYLGTNV 233
Cdd:PRK08045 154 VDIAKICHLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 234 ANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHqsefdKVLKTIYHSSL---QTEEFVKKQLvGGYGPVFAITLYTK 310
Cdd:PRK08045 234 GAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQ-----PLVKKLYHPSLpenQGHEIAARQQ-KGFGAMLSFELDGD 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6321904 311 EQC-KQLPLKLKYFHHATSLGGIESLVEWRA-MT----------DPYIDQTLIRVSVGCESANDLIKDLASALK 372
Cdd:PRK08045 308 EQTlRRFLGGLSLFTLAESLGGVESLISHAAtMThagmapearaAAGISETLLRISTGIEDGEDLIADLENGFR 381
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
6-372 |
1.59e-44 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 157.92 E-value: 1.59e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 6 TALIHGDDKDNRVTDVAPPINVSTTFRYDDDDLIpwTERENldfmEKKpvYSRLAHPNSTRLESIFSEILDGY-AVIYSS 84
Cdd:PRK08574 5 TDAVRGYRGSDPYGSLQPPIYLTALFRQEGEAYP--SDRGF----DLK--YSREENPTLRPLEEALAKLEGGVdALAFNS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 85 GLAAFYAAmvhynpkkiFIGQSYHGVRAIAniLTRNYGIEQHPLEDIEK-------------------CASEGDIVHLES 145
Cdd:PRK08574 77 GMAAISTL---------FFSLLKAGDRVVL--PMEAYGTTLRLLKSLEKfgvkvvlaypstediieaiKEGRTKLVFIET 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 146 PVNPYGTSSDIESLARRAHAKGALLIVDSTFASP----PLQYawnfGADIVLYSATKYFGGHSDLLSGVLVVKEEATSRQ 221
Cdd:PRK08574 146 MTNPTLKVIDVPEVAKAAKELGAILVVDNTFATPllyrPLRH----GADFVVHSLTKYIAGHNDVVGGVAVAWSGEFLEE 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 222 LKDDRIYLGTNVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHQsefdKVLKTIYhSSLQTEEF--VKKQLVGG- 298
Cdd:PRK08574 222 LWEWRRRLGTIMQPFEAYLVLRGLKTLEVRFERQCRNAMAIAEFLSEHP----KVAEVYY-PGLPSDPYhgVAKRLFGKd 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 299 -YGPVFAITLY-TKEQCKQLPLKLKYFHHATSLGGIESL----VEWRAMTDPY-------IDQTLIRVSVGCESANDLIK 365
Cdd:PRK08574 297 lYGGVVSFRVKgGRDAVLKFLRSLKLIKPSPSLGGVESLatypVKSAASPIPEedrkalgITEDLVRLSVGLEDVEDLIE 376
|
....*..
gi 6321904 366 DLASALK 372
Cdd:PRK08574 377 DLDQALG 383
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
54-374 |
2.91e-44 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 156.69 E-value: 2.91e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 54 PVYSRLAHPNSTRLESIFSEILDGYAVIYSSGLAAFYAA-MVHYNPkkifiGQS-------YHGVRAIANILTRNYGIE- 124
Cdd:PRK07582 43 DTYGRASNPTWRALEAALGELEGAEALVFPSGMAAITAVlRALLRP-----GDTvvvpadgYYQVRALAREYLAPLGVTv 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 125 -QHPLEDIEKCASEG-DIVHLESPVNPYGTSSDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGG 202
Cdd:PRK07582 118 rEAPTAGMAEAALAGaDLVLAETPSNPGLDVCDLAALAAAAHAAGALLVVDNTTATPLGQRPLELGADLVVASDTKALTG 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 203 HSDLLSGVLVVKEEATSRQLKDDRIYLGTNVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHqsefdKVLKTIYH 282
Cdd:PRK07582 198 HSDLLLGYVAGRDPELMAAVERWRLLAGAIPGPFEAWLAHRSLGTLGLRFARQCANALAVAELLAGH-----PAVRGVRY 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 283 SSLQTE---EFVKKQLVgGYGPVFAITLYTKEQCKQLPLKLKYFHHATSLGGIESLVEWRAMTDPYIDQTLIRVSVGCES 359
Cdd:PRK07582 273 PGLPGDpahEVAARQMR-RFGGLVSFELADAAAAERFVAASRLVVAATSFGGVHTSADRRARWGDAVPEGFVRLSCGIED 351
|
330
....*....|....*
gi 6321904 360 ANDLIKDLASALKEL 374
Cdd:PRK07582 352 TDDLVADLERALDAL 366
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
11-375 |
3.74e-44 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 156.40 E-value: 3.74e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 11 GDDKDNRVTDVAPPINVSTTFRYDDddlipWTERENLDfmekkpvYSRLAHPNSTRLESIFSEILDG---YAviYSSGLA 87
Cdd:PRK08247 13 GNRSDERTGTVNPPVYFSTAYRHEG-----IGESTGFD-------YSRTGNPTRGVLEQAIADLEGGdqgFA--CSSGMA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 88 AFYAAMVHYNPKKIFIGQS--YHGVRAIANILTRNYGIEQH-----PLEDIEKCASEG-DIVHLESPVNPYGTSSDIESL 159
Cdd:PRK08247 79 AIQLVMSLFRSGDELIVSSdlYGGTYRLFEEHWKKWNVRFVyvntaSLKAIEQAITPNtKAIFIETPTNPLMQETDIAAI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 160 ARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKEEATSRQLKDDRIYLGTNVANLESF 239
Cdd:PRK08247 159 AKIAKKHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQELCERLAYYQNAAGAVLSPFDSW 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 240 MLLRSLRTYEMRITKQSENATKLVRFLSDHqsefDKVLKTIYHSS-------LQTEEFVKKQLvggygpvfaitlytkeq 312
Cdd:PRK08247 239 LLIRGMKTLALRMRQHEENAKAIAAFLNEQ----PGVTDVLYPGRggmlsfrLQDEEWVNPFL----------------- 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6321904 313 cKQlpLKLKYFhhATSLGGIESLVEWRA----MTDPY-------IDQTLIRVSVGCESANDLIKDLASALKELQ 375
Cdd:PRK08247 298 -KS--LKLITF--AESLGGVESFITYPAtqthADIPEeiriangVCNRLLRFSVGIENVEDLIADLKQAFKQVK 366
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
5-377 |
4.43e-43 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 154.38 E-value: 4.43e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 5 STALIHGDDKDNRVTDVAPPINVSTTFRYDDddlipwterenldFMEKKPV-YSRLAHPNSTRLESIFSEILDGYA-VIY 82
Cdd:PRK08776 15 TAAVRAGIDRDTAYGAVTPPIVLSSNFSFDG-------------FGNKRQYdYTRSGNPTRDLLGEALAELEGGAGgVIT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 83 SSGLAAF---YAAMVHYNPKKIFIGQSYHGVRAIANILTRNYGIE------QHPLEDIEKCASEGDIVHLESPVNPYGTS 153
Cdd:PRK08776 82 ATGMGAInlvLNALLQPGDTLVVPHDAYGGSWRLFNALAKKGHFAlitadlTDPRSLADALAQSPKLVLIETPSNPLLRI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 154 SDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKEEATSRQLKDDRIYLGTNV 233
Cdd:PRK08776 162 TDLRFVIEAAHKVGALTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAVVARDAELHQQLVWWANALGLTG 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 234 ANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHqsefdKVLKTIYHSSLQTE--EFVKKQLVGGYGPVFAITLYTKE 311
Cdd:PRK08776 242 SPFDAFLTLRGLRTLDARLRVHQENADAIAALLDGH-----AAVNQVYYPGLASHpgHALAARQQKGFGAMLSFELEGGE 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6321904 312 -QCKQLPLKLKYFHHATSLGGIESLVEW-----------RAMTDPYIDQTLIRVSVGCESANDLIKDLASALKELQDA 377
Cdd:PRK08776 317 aAVRAFVDGLRYFTLAESLGGVESLIAHpasmthaamtaEARAAAGISDGLLRLSVGIESAEDLLIDLRAGLARAEAV 394
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
4-372 |
3.61e-36 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 136.31 E-value: 3.61e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 4 LSTALIH-GDDKDNRVTDVAPPINVSTTFRYDDddlipwTER-ENL-DFMEKKPVYSRLAHPNSTRLESIFSEiLDG--Y 78
Cdd:COG2873 8 FETLALHaGQEPDPTTGARAVPIYQTTSYVFDD------AEHaADLfALKEPGNIYTRIMNPTTDVLEKRIAA-LEGgvA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 79 AVIYSSGLAAfyaamvhynpkkIFIgqsyhgvrAIANIL---------------TRN--------YGIE-----QHPLED 130
Cdd:COG2873 81 ALATASGQAA------------ITL--------AILNLAeagdhivassslyggTYNlfahtlprLGIEvrfvdPDDPEA 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 131 IE-------KCasegdiVHLESPVNPYGTSSDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGH 203
Cdd:COG2873 141 FEaaidpntKA------IFGETIGNPALDVLDIEAIAEIAHEHGVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGH 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 204 SDLLSGVLV--------------------------------------VKeeATSRQLKDdriyLGTNVANLESFMLLRSL 245
Cdd:COG2873 215 GTSIGGVIVdggnfdwaangkfpeltepdpsyhglvyteafgnaafiTK--ARVQLLRD----LGAALSPFNAFLLLQGL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 246 RTYEMRITKQSENATKLVRFLSDHqsefDKVLKTIYhSSLQ---TEEFVKKQLVGGYGPVFAITL-YTKEQCKQLPLKLK 321
Cdd:COG2873 289 ETLSLRMERHVENALKVAEFLEAH----PKVAWVNY-PGLPshpYHELAQKYLPKGAGGVLTFGLkGGREAGKKFIDSLK 363
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6321904 322 YFHHATSLGGIESLV-------------EWRAMTDpyIDQTLIRVSVGCESANDLIKDLASALK 372
Cdd:COG2873 364 LFSHLANIGDAKSLVihpastthsqlseEEQAAAG--VTPDLIRLSVGIEDIDDIIADLDQALA 425
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
56-374 |
3.64e-36 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 135.34 E-value: 3.64e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 56 YSRLAHPNSTRLESIFSEILDG-YAVIYSSGLAAFYA-----------AMVHYNpkkiFIGQSYHgvraIANILTRNYGI 123
Cdd:PRK06460 39 YSREANPTVLELTKKIVELENAeMGVAFSSGMGAISTtalallkpgnsVLVHRD----MFGRSYR----FFTDYLKNWGV 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 124 E---QHPLED--IEKCASEG-DIVHLESPVNPYGTSSDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSAT 197
Cdd:PRK06460 111 NvdaSNPGSDniIEKAKSKRyDVVFVENITNPLLRVVDITELSKVCKENGSILIVDATFSTPINQKPLELGADIVVHSAS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 198 KYFGGHSDLLSGVLVVKEEATSRqLKDDRIYLGTNVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHqsefDKVL 277
Cdd:PRK06460 191 KFLAGHNDVIAGLAAGYGKLLNV-IDQMRRTLGTSLDPHAAYLTLRGIKTLKIRMDVINRNAEQIAEFLEGH----PKVV 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 278 KTIYHSSLQTEEF-VKKQLVGGYGPVFAITLY-TKEQCKQLPLKLKYFHHATSLGGIESLVewramTDPY---------- 345
Cdd:PRK06460 266 KVYYPGLKSHVDYeIARRVLKGFGGVLSFEVNgGQESALKVMKSLKLIIPAQTLGGVNSVI-----SHPAtmshrtlsle 340
|
330 340 350
....*....|....*....|....*....|....*
gi 6321904 346 ------IDQTLIRVSVGCESANDLIKDLASALKEL 374
Cdd:PRK06460 341 erkivgITDSLLRLSVGIEDVNDLIEDLDRALSTL 375
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
7-378 |
3.06e-35 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 133.39 E-value: 3.06e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 7 ALIHGDDKDNRVTDVAPPINVSTTFRYDDddlipwTERENLDFMEKKP--VYSRLAHPNSTRLESIFSEILDGYA-VIYS 83
Cdd:PRK07503 14 AIHHGYDPLDHGGALVPPVYLTATFAFPT------AEYGAECFAGEEEghFYSRISNPTLALLEQRMASLEGGEAaVALA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 84 SGLAAFYAAMVHY-NP-KKIFIGQSYHGVR--AIANILTRnYG--IEQHPLEDIEKCA----SEGDIVHLESPVNPYGTS 153
Cdd:PRK07503 88 SGMGAITATLWTLlRPgDEVIVDQTLYGCTfaFLHHGLGE-FGvtVRHVDLTDPAALKaaisDKTRMVYFETPANPNMRL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 154 SDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKEEATSR----QLKDdriYL 229
Cdd:PRK07503 167 VDIAAVAEIAHGAGAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLVVGGKALADRirleGLKD---MT 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 230 GTNVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHQSefdkvLKTIYHSSLQT---EEFVKKQLVGGyGPVFAIT 306
Cdd:PRK07503 244 GAVMSPFDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPA-----VELVHYPGLPSfaqHALAQRQMALP-GGMIAFE 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 307 LYTK-EQCKQLPLKLKYFHHATSLGGIESLVEWRA-MT-DPY---------IDQTLIRVSVGCESANDLIKDLASALKEL 374
Cdd:PRK07503 318 LKGGiAAGRRFMNALQLFARAVSLGDAESLAQHPAsMThSTYtpeeraehgISEGLVRLSVGLEDVADILADLAQALDAC 397
|
....
gi 6321904 375 QDAA 378
Cdd:PRK07503 398 AVAA 401
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
7-372 |
1.91e-34 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 130.97 E-value: 1.91e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 7 ALIHGDDKDNRVTDVAPPINVSTTFRYDD-DDLIPWTERENldfmeKKPVYSRLAHPNSTRLESIFSEiLDGY--AVIYS 83
Cdd:PRK05968 12 ALITAHDEGNAFDAVVPPIFQTSLFTFDSyDEMEDVYAGEK-----VRPIYSRGDNPTVRAFEEMLAK-LEGAedARGFA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 84 SGLAAFYA---AMVHYNPKKIFIGQSYHGV-RAIANILTRnYGIEQHPL-----EDIEKCASEGDIVHLESPVNPYGTSS 154
Cdd:PRK05968 86 SGMAAISStvlSFVEPGDRIVAVRHVYPDAfRLFETILKR-MGVEVDYVdgrdeEAVAKALPGAKLLYLESPTSWVFELQ 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 155 DIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKEEATSRQLKDDRIYLGTNVA 234
Cdd:PRK05968 165 DVAALAALAKRHGVVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVAGSKEHIARINAEAYPYLGAKLS 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 235 NLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHQsefdkVLKTIYHSSLQTEefvKKQLVGGYGPVFAITLYTKEQCK 314
Cdd:PRK05968 245 PFEAWLLLRGLRTLPLRMKAHEASALEIARRLKAHP-----VVERVCHPALANH---PPAGLSGTSGLFSFIFREGIDVR 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6321904 315 QLPLKLKYFHHATSLGGIESLV-------EWRAMTDPY----IDQTLIRVSVGCESANDLIKDLASALK 372
Cdd:PRK05968 317 AFADALKLFRLGVSWGGHESLVvpaevvlQQKAQPNSAarfgVSPRSVRLHVGLEGTEALWADLEQALA 385
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
55-372 |
8.52e-34 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 129.49 E-value: 8.52e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 55 VYSRLAHPNSTRLESIFSEiLDGY--AVIYSSGLAAFYAAMV-------HYNPKKIFIGQsyhgVRAIANILTRNYGIEQ 125
Cdd:PRK07504 58 IYSRYSNPTVDMFEKRMCA-LEGAedARATASGMAAVTAAILcqvkagdHVVAARALFGS----CRYVVETLLPRYGIES 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 126 -----HPLEDIEKCASEGDIV-HLESPVNPYGTSSDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKY 199
Cdd:PRK07504 133 tlvdgLDLDNWEKAVRPNTKVfFLESPTNPTLEVIDIAAVAKIANQAGAKLVVDNVFATPLFQKPLELGAHIVVYSATKH 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 200 FGGHSDLLSGVLVVKEEATSRQLKDDRIYLGTNVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHqsefDKVLKT 279
Cdd:PRK07504 213 IDGQGRCLGGVVLSDKAWIEEHLQDYFRHTGPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGH----PKVARV 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 280 IY-----HSSLQTeefVKKQLVGGYGPVFAITLYTKEQCKQLPLKLKYFHHATSLGGIESLVEWRAMT-----------D 343
Cdd:PRK07504 289 IYpgradHPQADI---IAKQMTGGSTLVAFELKGGKEAAFRFLNALKIVRISNNLGDAKSLITHPATTthknlspearaE 365
|
330 340
....*....|....*....|....*....
gi 6321904 344 PYIDQTLIRVSVGCESANDLIKDLASALK 372
Cdd:PRK07504 366 LGISEGFLRLSAGLEDTDDLIEDLAAALK 394
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
6-374 |
1.72e-31 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 122.68 E-value: 1.72e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 6 TALIH-GDDKDNRVTDVAPPINVSTTFRYDDDDlipwTERENLDfmekKPVYSRLAHPNSTRLESIFSEILDGYAVI-YS 83
Cdd:TIGR01324 1 TRLIHsGRQPRFSQGSVNPPLQRASTVLFDSHA----AQRRAKG----ELTYGRRGTLTHFALQDAMCELEGGAGCYlYP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 84 SGLAAFYAAM---VHYNPKKIFIGQSYHGVRAIANILTRNYGIE-----QHPLEDIEK-CASEGDIVHLESPVNPYGTSS 154
Cdd:TIGR01324 73 SGLAAVTNSIlafVKAGDHVLMVDSAYEPTRYFCDIVLKRMGVDityydPLIGEDIATlIQPNTKVLFLEAPSSITFEIQ 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 155 DIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVlVVKEEATSRQLKDDRIYLGTNVA 234
Cdd:TIGR01324 153 DIPAIAKAARNPGIVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYLVGHSDIMIGT-VVANARTWDQLREHSYLMGQMVD 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 235 NLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHqsefdKVLKTIYHSSLQTE---EFVKKQLVGGYGpVFAITLY--T 309
Cdd:TIGR01324 232 ADDAYTTLRGLRTLGVRLKQHQESSLAIAKWLSEQ-----PEVARVLHPALPSCpghEFWKRDFSGSSG-LFSFVLQrlT 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6321904 310 KEQCKQLPLKLKYFHHATSLGGIESLV--EWRAMTD------PYiDQTLIRVSVGCESANDLIKDLASALKEL 374
Cdd:TIGR01324 306 QKQVHAFLDHLQLFGLGYSWGGYESLAlcNQPELGHrpnikrNL-EGPLIRVHIGLENVDDLKADLKAGFEAI 377
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
22-378 |
8.78e-31 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 121.77 E-value: 8.78e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 22 APPINVSTTFRYDDDDlipwtERENLDFMEKKP-VYSRLAHPNSTRLESIFSEILDGY-AVIYSSGLAAFYAAMVhynpk 99
Cdd:PRK08134 28 AVPIHLTTSFVFRDSD-----HAAALFNLERAGhVYSRISNPTVAVLEERVAALEGGVgAIATASGQAALHLAIA----- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 100 kIFIGQSYHGVRAIA------NILT---RNYGIEQ---HPlEDIEKCAS----EGDIVHLESPVNPYGTSSDIESLARRA 163
Cdd:PRK08134 98 -TLMGAGSHIVASSAlyggshNLLHytlRRFGIETtfvKP-GDIDGWRAairpNTRLLFGETLGNPGLEVLDIPTVAAIA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 164 HAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLV---------------------------VKEE 216
Cdd:PRK08134 176 HEAGVPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLVdggrfdweasgkfpeltepyagfhgmvFAEE 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 217 AT-------SRQ--LKDdriyLGTNVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHqsefdKVLKTIYHSSLQT 287
Cdd:PRK08134 256 STvaafllrARRegLRD----FGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASH-----PAVARVAHPELES 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 288 E---EFVKKQLVGGYGPVFAITLY-TKEQCKQLPLKLKYFHHATSLGGIESLVEWRAMTDPY-----------IDQTLIR 352
Cdd:PRK08134 327 HpdhALAKRLLPRGAGSVFSFDLKgGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFrmdaaalaaagIGEGTIR 406
|
410 420
....*....|....*....|....*.
gi 6321904 353 VSVGCESANDLIKDLASALKELQDAA 378
Cdd:PRK08134 407 LSIGLEDADDLIDDLKRALKAAEKAG 432
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
51-372 |
2.09e-30 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 119.72 E-value: 2.09e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 51 EKKPVYSRLAHPNSTRLESIFSEiLDG--YAVIYSSGLAAFYAAMV-------HynpkkIFIGQSYHG--VRAIANILTR 119
Cdd:PRK08133 50 EPGNIYSRFTNPTVTMFQERLAA-LEGaeACVATASGMAAILAVVMallqagdH-----VVSSRSLFGstVSLFEKIFAR 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 120 nYGIEQH--PLEDIEK----CASEGDIVHLESPVNPYGTSSDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVL 193
Cdd:PRK08133 124 -FGIETTfvDLTDLDAwraaVRPNTKLFFLETPSNPLTELADIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVI 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 194 YSATKYFGGHSDLLSGVLVVKEEatsrQLKDDRIYLGTNVANLESF---MLLRSLRTYEMRITKQSENATKLVRFLSDHq 270
Cdd:PRK08133 203 HSATKYLDGQGRVLGGAVVGSKE----LMEEVFGFLRTAGPTLSPFnawVFLKGLETLSLRMEAHSANALALAEWLEAH- 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 271 sefDKVLKtIYHSSLQTE---EFVKKQLVGGyGPVFAITLY-TKEQCKQLPLKLKYFHHATSLGGIESLV---------- 336
Cdd:PRK08133 278 ---PGVER-VFYPGLPSHpqhELAKRQQKGG-GAIVSFEVKgGREAAWRVIDATRLISITANLGDTKTTIthpattthgr 352
|
330 340 350
....*....|....*....|....*....|....*....
gi 6321904 337 ---EWRAMTDpyIDQTLIRVSVGCESANDLIKDLASALK 372
Cdd:PRK08133 353 lspEARAAAG--ITEGLIRVAVGLEDVADIKADLARGLA 389
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
4-375 |
3.66e-30 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 119.95 E-value: 3.66e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 4 LSTALIH-GDDKDNRVTDVAPPINVSTTFRYDDDDlipwtERENLdFMEKKP--VYSRLAHPNSTRLESIFSEILDGY-A 79
Cdd:PRK08248 9 LETLAIHaGQEIDPTTGSRAVPIYQTTSYGFRDSE-----HAANL-FSLKEFgnIYTRIMNPTTDVFEKRIAALEGGIgA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 80 VIYSSGLAA-FYAAM-VHYNPKKIFIGQS-YHGVRAIANILTRNYGIEQH-----PLEDIEKCASE-GDIVHLESPVNPY 150
Cdd:PRK08248 83 LAVSSGQAAiTYSILnIASAGDEIVSSSSlYGGTYNLFAHTLPKLGITVKfvdpsDPENFEAAITDkTKALFAETIGNPK 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 151 GTSSDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLV------------------ 212
Cdd:PRK08248 163 GDVLDIEAVAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVdsgkfdwkgsgkfpglte 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 213 --------VKEEATSRQ----------LKDdriyLGTNVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHQSefd 274
Cdd:PRK08248 243 pdpsyhglVYTDAVGEAayitkarvqlLRD----LGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEA--- 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 275 kvLKTIYHSSLQTE---EFVKKQLVGGYGPVFAITLY-TKEQCKQLPLKLKYFHHATSLGGIESLVEWRAMT-------- 342
Cdd:PRK08248 316 --VEWVSYPGLPSHpsyELAKKYLPKGQGAILTFGIKgGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTthqqlsee 393
|
410 420 430
....*....|....*....|....*....|....*.
gi 6321904 343 ---DPYIDQTLIRVSVGCESANDLIKDLASALKELQ 375
Cdd:PRK08248 394 eqlAAGVTPGLVRLSVGTEAIDDILDDLRQAIRQSQ 429
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
56-377 |
1.35e-28 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 114.83 E-value: 1.35e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 56 YSRLAHPNSTRLESIFSEILDGYA-VIYSSGLAAFYAAMVHY---NPKKIFIGQSYHGVRAIANILTRNYGIEQ---HPL 128
Cdd:PRK09028 55 YGRRGTPTHFAFQAAIVELEGGAGtALYPSGAAAISNALLSFlkaGDHLLMVDSCYEPTRDLCDKILKGFGIETtyyDPM 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 129 --EDIEKCASEG-DIVHLESPVNPYGTSSDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSD 205
Cdd:PRK09028 135 igEGIRELIRPNtKVLFLESPGSITMEVQDVPTLSRIAHEHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSD 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 206 LLSGVlVVKEEATSRQLKDDRIYLGTNVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHqSEFDKVLktiyHSSL 285
Cdd:PRK09028 215 VMLGT-ATANEKHWDQLREHSYLMGQCTSPDDVYLAMRGLRTLGVRLAQHEKNALKVANWLATR-PEVDHVR----HPAF 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 286 QT---EEFVKKQLVGGYGpVFAITLYT--KEQCKQLPLKLKYFHHATSLGGIESLV-------EWRAMTDPYIDQTLIRV 353
Cdd:PRK09028 289 ETcpgHEFFKRDFSGSNG-LFSFVLKQgdPKAVTALVEGMQHFKMGFSWGGFESLIlgvfginKLRTATNWDFSKPLIRL 367
|
330 340
....*....|....*....|....
gi 6321904 354 SVGCESANDLIKDLASALKELQDA 377
Cdd:PRK09028 368 HIGLEDVDDLIADLEAGFERYNAV 391
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
4-371 |
1.34e-27 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 112.21 E-value: 1.34e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 4 LSTALIH-GDDKDNRVTDVAPPINVSTTFRYDDddlipwteRENLDFMEKKPVYSRLAHPNSTRLESIFSEiLDGYA--V 80
Cdd:PRK05967 13 INTRLAHdGNDPGDYHGFVNPPVVHASTVLFPD--------AETMATRGQKYTYGTRGTPTTDALCKAIDA-LEGSAgtI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 81 IYSSGLAAF---YAAMVHYNPKKIFIGQSYHGVRAIANILTRNYGIEQH---PL--EDIEKCASEG-DIVHLESPVNPYG 151
Cdd:PRK05967 84 LVPSGLAAVtvpFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVEVEyydPEigAGIAKLMRPNtKVVHTEAPGSNTF 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 152 TSSDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVlVVKEEATSRQLKDDRIYLGT 231
Cdd:PRK05967 164 EMQDIPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGT-VSANEKCWPQLLEAHGTLGL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 232 NVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHQsEFDKVLktiyHSSLQT---EEFVKKQLVGGYGpVFAITL- 307
Cdd:PRK05967 243 CAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLEGRP-DVARVL----HPALPSfpgHEIWKRDFSGASG-IFSFVLa 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6321904 308 ----YTKEQCKQLPLKLKYFHHATSLGGIESL-----VEWRAMTDPYIDQTLIRVSVGCESANDLIKDLASAL 371
Cdd:PRK05967 317 agpeKGKAKAHAFLDALEIFGLGYSWGGYESLalhvkLGDRTVAKAPYAGPVIRLQIGLEDVPDLKADLERGF 389
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
55-372 |
1.37e-27 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 112.13 E-value: 1.37e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 55 VYSRLAHPNStrleSIFSE---ILDGYAVIY--SSGLAAFYAAM--VHYNPKKIFIGQSYHG-VRAIAN-ILTRnYGIEQ 125
Cdd:PRK07810 63 VYSRYGNPTV----SMFEErlrLIEGAEACFatASGMSAVFTALgaLLGAGDRLVAARSLFGsCFVVCNeILPR-WGVET 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 126 -----HPLEDIEKCASE-GDIVHLESPVNPYGTSSDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKY 199
Cdd:PRK07810 138 vfvdgEDLSQWEEALSVpTQAVFFETPSNPMQSLVDIAAVSELAHAAGAKVVLDNVFATPLLQRGLPLGADVVVYSGTKH 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 200 FGGHSDLLSGVLVVKEEATSRQLKDDRIYLGTNVANLESFMLLRSLRTYEMRITKQSENATKLVRFLsDHQSEFDKVLKT 279
Cdd:PRK07810 218 IDGQGRVLGGAILGDREYIDGPVQKLMRHTGPALSAFNAWVLLKGLETLALRVRHSNASALRIAEFL-EGHPAVRWVRYP 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 280 IYHSSLQtEEFVKKQLVGGyGPVFAITL-----YTKEQCKQLPLKLKYFHHATSLGGIESLV-------------EWRA- 340
Cdd:PRK07810 297 FLPSHPQ-YDLAKRQMSGG-GTVVTFELdapedAAKKRAFEVLDKLRVIDISNNLGDAKSLIthpattthramgpEGRAa 374
|
330 340 350
....*....|....*....|....*....|....
gi 6321904 341 --MTDpyidqTLIRVSVGCESANDLIKDLASALK 372
Cdd:PRK07810 375 igLGD-----GVVRLSVGLEDTDDLIADLDRALG 403
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
141-371 |
3.55e-27 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 111.34 E-value: 3.55e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 141 VHLESPVNPYGTSSDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVvkEEATSR 220
Cdd:PRK05994 152 IFIESIANPGGTVTDIAAIAEVAHRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIV--DGGTFD 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 221 QLKDDRI---------Y-------------------------LGTNVANLESFMLLRSLRTYEMRITKQSENATKLVRFL 266
Cdd:PRK05994 230 WSKSGKYpmlseprpeYhglvlhetfgnfafaiaarvlglrdLGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWL 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 267 SDHqsefDKVLKTIYhSSLQTE---EFVKKQLVGGYGPVFAITL---YtkEQCKQLPLKLKYFHHATSLGGIESLV---- 336
Cdd:PRK05994 310 KGH----PKVSWVNY-AGLPDDpyhALAQKYSPKGAGAVFTFGLkggY--EAGVKLVSSLKLFSHLANIGDTRSLVihpa 382
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 6321904 337 --EWRAMTDpyiDQT--------LIRVSVGCESANDLIKDLASAL 371
Cdd:PRK05994 383 stTHRQLTD---EQKvaagagpdVVRLSIGIEDVDDIIADLEQAL 424
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
140-375 |
3.11e-26 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 108.25 E-value: 3.11e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 140 IVHLESPVNPYGTSSDIESLAR--RAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVvkeeA 217
Cdd:PRK08114 150 VVFLESPGSITMEVHDVPAIVAavRSVNPDAVIMIDNTWAAGVLFKALDFGIDISIQAGTKYLVGHSDAMIGTAV----A 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 218 TSR---QLKDDRIYLGTNVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHQSefdkvLKTIYHSSLQT---EEFV 291
Cdd:PRK08114 226 NARcweQLRENSYLMGQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPE-----VARVNHPALPGckgHEFW 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 292 KKQLVGGYGpVFAITLYTKEQCKQLPLKLKYFHH---ATSLGGIESLV-----EWRAMTDPYIDQ----TLIRVSVGCES 359
Cdd:PRK08114 301 KRDFTGSSG-LFSFVLKKKLTDEQLANYLDNFSLfsmAYSWGGFESLIlanqpEEIAAIRPAGEVdftgTLIRLHIGLED 379
|
250
....*....|....*.
gi 6321904 360 ANDLIKDLASALKELQ 375
Cdd:PRK08114 380 VDDLIADLAAGFARIV 395
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
24-372 |
3.32e-26 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 108.24 E-value: 3.32e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 24 PINVSTTFRYDD-DDLIPWterenldFMEKKP--VYSRLAHPNSTRLESIFSEILDGYAVI-YSSGLAAFYAAMV----- 94
Cdd:PRK05939 13 PIHTSVTYGYEDaRDLIDV-------FQGKKPgfTYARQGTPTTAALEAKITKMEGGVGTVcFATGMAAIAAVFLtllra 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 95 --HYNPKKIFIGQSyhgvRAIANILtRNYGIEQHPLE--DIEKCAS----EGDIVHLESPVNPYGTSSDIESLARRAHAK 166
Cdd:PRK05939 86 gdHLVSSQFLFGNT----NSLFGTL-RGLGVEVTMVDatDVQNVAAairpNTRMVFVETIANPGTQVADLAGIGALCRER 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 167 GALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLV----------------VKEEATSRQ--------- 221
Cdd:PRK05939 161 GLLYVVDNTMTSPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVTdtglfdwsaypnifpaYRKGDPQQWgltqirkkg 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 222 LKDDRIYLGTNVANLESFmllrSLRTYEMRITKQSENATKLVRFLSDHQsefdKVLKtIYHSSLQT--EEFVKKQLVGGY 299
Cdd:PRK05939 241 LRDMGATLSSEAAHRIAI----GAETLALRVDRSCSNALALAQFLEAHP----KVAR-VYYPGLAShpQHARATELFRHY 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 300 GPVFAITLYTKEQCKQLPLKLKYFHHATSLGGIESLV-------------EWRAMTDpyIDQTLIRVSVGCESANDLIKD 366
Cdd:PRK05939 312 GGLLSFELADGIDCFDFLNRLKLVIKATHLGDTRTLVipvaptiyyemgaERRASMG--IADSLIRVSVGIEDEADLIAD 389
|
....*.
gi 6321904 367 LASALK 372
Cdd:PRK05939 390 FEQALD 395
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
4-371 |
1.19e-24 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 104.21 E-value: 1.19e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 4 LSTALIH-GDDKDNRVTDVAPPINVSTTFRYDDD----DLipwterenLDFMEKKPVYSRLAHPNSTRLESIFSEILDGY 78
Cdd:PRK06084 3 LETLAIHaGYSPDPTTKAVAVPIYQTTSYAFDDTqhgaDL--------FDLKVPGNIYTRIMNPTNDVLEQRVAALEGGV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 79 -AVIYSSGLAAF-YA--AMVHYNPKKIFIGQSYHGV-RAIANILTRnYGIEQHPLEDIEKCASEGDI------VHLESPV 147
Cdd:PRK06084 75 gALAVASGMAAItYAiqTIAEAGDNIVSVAKLYGGTyNLLAHTLPR-IGIETRFAAHDDIAALEALIdertkaVFCESIG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 148 NPYGTSSDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKEEATSRQLKD--- 224
Cdd:PRK06084 154 NPAGNIIDIQALADAAHRHGVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVDSGKFPWAEHKErfa 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 225 -----DRIYLGTN-------------------------VANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDH-QSEF 273
Cdd:PRK06084 234 llntpDPSYHGVTyteafgpaafigrcrvvplrnmgaaLSPFNAFLILQGLETLALRMERHTENALKVARYLQQHpQVAW 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 274 DKVLKTIYHSSlqtEEFVKKQLVGGYGPVFAITLYTKEQCK-------QLPLKLKYFHHATSLGGIESLVEWRAMTDPY- 345
Cdd:PRK06084 314 VKYAGLPDHPE---HELARRYMGGKPASILSFGIKGGQAAGarfidalKLVVRLVNIGDAKSLACHPASTTHRQLNDEEl 390
|
410 420 430
....*....|....*....|....*....|
gi 6321904 346 ----IDQTLIRVSVGCESANDLIKDLASAL 371
Cdd:PRK06084 391 ekagVSRDMVRLSIGIEHIDDIIADLAQAL 420
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
56-371 |
1.53e-24 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 103.65 E-value: 1.53e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 56 YSRLAHPNSTRLESIFSEILDG-YAVIYSSGLAAF---YAAMVHYNPKKIFIGQSYHGVRAIANILTRNYGIE---QHPL 128
Cdd:PRK07050 59 YGLHATPTSLALAQRLAEIEGGrHALLQPSGLAAIslvYFGLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITvrfYDPL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 129 --EDI-EKCASEGDIVHLESPVNPYGTSSDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSD 205
Cdd:PRK07050 139 igAGIaDLIQPNTRLIWLEAPGSVTMEVPDVPAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSD 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 206 LLSGVLVVKEEATSRQLKDDRIYLGTNVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHqSEFDKVLktiyHSSL 285
Cdd:PRK07050 219 VLMGATITADAELHAKLKLARMRLGIGVSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKAR-PEIATVL----HPAL 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 286 QT---EEFVKKQLVGGYGpVFAITL---YTKEQCKQLPLKLKYFHHATSLGGIESLV------EWRAMTDPYiDQTLIRV 353
Cdd:PRK07050 294 PDcpgHAFWMRDFTGAGG-LFSVVFderYSPAQVDAFVEALELFAIGWSWGGACSLAmpydvaSMRTAKWPH-RGTLVRL 371
|
330
....*....|....*...
gi 6321904 354 SVGCESANDLIKDLASAL 371
Cdd:PRK07050 372 YIGLEDEADLIADLEQAL 389
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
6-371 |
1.02e-23 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 101.75 E-value: 1.02e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 6 TALIHGDDKDNRVTDV-APPINVSTTFRYDDDD----LIPWTERENldfmekkpVYSRLAHPNSTRLESIFSEILDGY-A 79
Cdd:PRK07812 16 TKQIHAGQTPDPATNArALPIYQTTSYTFDDTDhaaaLFGLAEPGN--------IYTRIMNPTQDVVEQRIAALEGGVaA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 80 VIYSSGLAAFYAAMVHYNPKKIFIGQS---YHGVRAIANILTRNYGIEQHPLEDIEKCASEGDIV-------HLESPVNP 149
Cdd:PRK07812 88 LLLASGQAAETFAILNLAGAGDHIVSSprlYGGTYNLFHYTLPKLGIEVSFVEDPDDLDAWRAAVrpntkafFAETISNP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 150 YGTSSDIESLARRAHAKGALLIVDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLV----------------- 212
Cdd:PRK07812 168 QIDVLDIPGVAEVAHEAGVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIVdggtfdwtqgrfpgftt 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 213 -------------------VKeeATSRQLKDdriyLGTNVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHqsef 273
Cdd:PRK07812 248 pdpsyhgvvfaelgppayaLK--ARVQLLRD----LGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEAR---- 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 274 DKVLKTIYHS--SLQTEEFVKKQLVGGYGPVFAITLYTK-EQCKQLPLKLKYFHHATSLGGIESLVEWRAMT-----DPY 345
Cdd:PRK07812 318 DEVASVNYAGlpSSPWYERAKRLAPKGTGAVLSFELAGGvEAGKAFVNALTLHSHVANIGDVRSLVIHPASTthsqlTPE 397
|
410 420 430
....*....|....*....|....*....|..
gi 6321904 346 ------IDQTLIRVSVGCESANDLIKDLASAL 371
Cdd:PRK07812 398 eqlatgVTPGLVRLAVGIEGIDDILADLEAGF 429
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
24-367 |
1.38e-21 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 95.71 E-value: 1.38e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 24 PINVSTTFRYDDDDLIpwTERENLDfmEKKPVYSRLAHPNSTRLESIFSEILDG-YAVIYSSGLAAFYAAMVHYNPKKIF 102
Cdd:PRK05613 35 PIYQTTSYVFDSAEHA--KQRFALE--DLGPIYSRLTNPTVEALENRIASLEGGvHAVAFASGQAAETAAILNLAGAGDH 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 103 IGQS---YHGVRAIANILTRNYGIEQHPLEDIEKCASEGDIV-------HLESPVNPYGTSSDIESLARRAHAKGALLIV 172
Cdd:PRK05613 111 IVTSprlYGGTETLFLVTLNRLGIEVTFVENPDDPESWQAAVqpntkafFGETFANPQADVLDIPAVAEVAHRNQVPLIV 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 173 DSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLVVKEEATSRQLKD-----------DRIYLGTNVANL----- 236
Cdd:PRK05613 191 DNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLIDGGKFDWTVERDgkpvfpyfvtpDPAYHGLKYADLgapaf 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 237 -------------------ESFMLLRSLRTYEMRITKQSENATKLVRFLSDHQsefdKVLKTIYhSSLQTEEF--VKKQL 295
Cdd:PRK05613 271 glkaragllrdtgatlspfNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHE----KVAKVNF-AGLKDSPWyaTKEKL 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 296 VGGY-GPVFAITLY-TKEQCKQLPLKLKYFHHATSLGGIESLV-----------EWRAMTDPYIDQTLIRVSVGCESAND 362
Cdd:PRK05613 346 GLKYtGSVLSFDIKgGKDEAWAFIDALKLHSNLANIGDVRSLVvhpattthsqsDEAGLARAGITQATVRLSVGIEDIDD 425
|
....*
gi 6321904 363 LIKDL 367
Cdd:PRK05613 426 IIADL 430
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
55-356 |
1.28e-16 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 80.58 E-value: 1.28e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 55 VYSRlaHPNSTRLE-SIFSEILDGYAVIY--SSGLAAFYAAMV-------HYNPKKIFIGQSY----HGVRAIANILTRN 120
Cdd:PLN02242 69 IYSR--HFNPTVLNlGRQMAALEGTEAAYctASGMSAISSVLLqlcssggHVVASNTLYGGTHallaHFLPRKCNITTTF 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 121 YGIEQHplEDIEKCASEGD--IVHLESPVNPYGTSSDIESLARRAHAKGALLIVDSTFAsPPLQYAWNFGADIVLYSATK 198
Cdd:PLN02242 147 VDITDL--EAVKKAVVPGKtkVLYFESISNPTLTVADIPELARIAHEKGVTVVVDNTFA-PMVLSPARLGADVVVHSISK 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 199 YFGGHSDLLSGVlVVKEEATSRQLKDDR----IYLGTNVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHQsefd 274
Cdd:PLN02242 224 FISGGADIIAGA-VCGPAELVNSMMDLHhgalMLLGPTMNPKVAFELSERLPHLSLRMKEHCRRAMEYAKRMKELG---- 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 275 kvLKTIYhSSLQT---EEFVKKQLVGGY--GPVFAITLYTKEQCKQLPLKLKYFHH----ATSLGGIESLV--------- 336
Cdd:PLN02242 299 --LKVIY-PGLEDhpqHALLKSMANKGYgfGGLLCLDMDTEERANRLMRYLQNSTQfgfmAVSLGYYETLMscsgsstss 375
|
330 340
....*....|....*....|....
gi 6321904 337 ----EWRAMTDpyIDQTLIRVSVG 356
Cdd:PLN02242 376 eldpEEKAAAG--ISPGLVRMSVG 397
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
24-371 |
3.01e-14 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 73.55 E-value: 3.01e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 24 PINVSTTFRYD-DDDLIPWTERENLDFmekkpVYSRLAHPNSTRLESIFSEILDGY-AVIYSSGLAAFYAAMVHYNPKKI 101
Cdd:PRK06702 27 PLYQSTTYKYDtSDDLAALFNLEAEGY-----IYTRIGNPTLAAFEQKLAELEGGVgAVATASGQAAIMLAVLNICSSGD 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 102 FIGQS---YHGVRAIANILTRNYGIE----QHPLEDIEKCASEGD---IVHLESPVNPYGTSSDIESLARRAHAKGALLI 171
Cdd:PRK06702 102 HLLCSstvYGGTFNLFGVSLRKLGIDvtffNPNLTADEIVALANDktkLVYAESLGNPAMNVLNFKEFSDAAKELEVPFI 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 172 VDSTFASPPLQYAWNFGADIVLYSATKYFGGHSDLLSGVLV---------------------------VKEEATSRQLKD 224
Cdd:PRK06702 182 VDNTLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIdggnfdwtngkypelvepdpsyhgvsyVQNFGAAAYIVK 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 225 DRIYL----GTNVANLESFMLLRSLRTYEMRITKQSENATKLVRFLSDHQSefdkvLKTIYHSSLQTEE---FVKKQLVG 297
Cdd:PRK06702 262 ARVQLlrdyGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHER-----IEWVNYPGLDSNEnysLAQKYLKK 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 298 GYGPVFAITLYTK-EQCKQLPLKLKYFHHATSLGGIESLVEWRAMTD-----------PYIDQTLIRVSVGCESANDLIK 365
Cdd:PRK06702 337 GASGVLTFGIKGGlEAAKEFIANVKLATLVTHVADARTCVIHPASTThrqlsaedqrlAGVTSDLIRLSVGIEDVSDIIA 416
|
....*.
gi 6321904 366 DLASAL 371
Cdd:PRK06702 417 DLEAAL 422
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
76-214 |
2.22e-06 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 47.38 E-value: 2.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 76 DGYAVIYSSGLAAFYAA-MVHYNPKK--IFIGQSYHGVRAIA--------NILTRN----YGIEQHPLEDIEKcASEGDI 140
Cdd:cd01494 17 NDKAVFVPSGTGANEAAlLALLGPGDevIVDANGHGSRYWVAaelagakpVPVPVDdagyGGLDVAILEELKA-KPNVAL 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6321904 141 VHLESPVNPYGTSSDIESLARRAHAKGALLIVDSTFASP----PLQYAWNFGADIVLYSATKYFGGHSdllSGVLVVK 214
Cdd:cd01494 96 IVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGaspaPGVLIPEGGADVVTFSLHKNLGGEG---GGVVIVK 170
|
|
| GDC-P |
cd00613 |
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ... |
85-216 |
9.90e-04 |
|
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.
Pssm-ID: 99737 [Multi-domain] Cd Length: 398 Bit Score: 41.06 E-value: 9.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 85 GLAAFYAAMVHYNP-KKIFIGQSYHGV-RAIANILTRNYGIEqhpledIE--KCASEGDI---------------VHLES 145
Cdd:cd00613 94 AEAAGLAAIRAYHKrNKVLVPDSAHPTnPAVARTRGEPLGIE------VVevPSDEGGTVdlealkeevseevaaLMVQY 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 146 PvNPYGT-SSDIESLARRAHAKGALLIVDS-----TFASPPLQYawnfGADIVLYSATKYF------GGHsdllSGVLVV 213
Cdd:cd00613 168 P-NTLGVfEDLIKEIADIAHSAGALVYVDGdnlnlTGLKPPGEY----GADIVVGNLQKTGvphgggGPG----AGFFAV 238
|
...
gi 6321904 214 KEE 216
Cdd:cd00613 239 KKE 241
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
128-217 |
3.33e-03 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 39.15 E-value: 3.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 128 LEDIEKCASEG-DIVHLESPVNPYGTSSDIESLARRAHAKGALLIVDSTFASP--PLQYAwNFGADIVlysatkYFGGHS 204
Cdd:pfam00266 129 LDELEKLITPKtKLVAITHVSNVTGTIQPVPEIGKLAHQYGALVLVDAAQAIGhrPIDVQ-KLGVDFL------AFSGHK 201
|
90
....*....|....*..
gi 6321904 205 dLLS----GVLVVKEEA 217
Cdd:pfam00266 202 -LYGptgiGVLYGRRDL 217
|
|
| AGAT_like |
cd06451 |
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate ... |
79-201 |
6.89e-03 |
|
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-glyoxylate aminotransferase (SGAT), and 3-hydroxykynurenine transaminase (HKT). AGAT is a homodimeric protein, which catalyses the transamination of glyoxylate to glycine, and SGAT converts serine and glyoxylate to hydroxypyruvate and glycine. HKT catalyzes the PLP-dependent transamination of 3-hydroxykynurenine, a potentially toxic metabolite of the kynurenine pathway.
Pssm-ID: 99744 [Multi-domain] Cd Length: 356 Bit Score: 38.04 E-value: 6.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 79 AVIYSSGLAAFYAAMVHYNPK--KIFIGQSYH-GVRAiANILTRnYGIEQH----------PLEDIEKCASEGD-----I 140
Cdd:cd06451 53 FLLSGSGTGAMEAALSNLLEPgdKVLVGVNGVfGDRW-ADMAER-YGADVDvvekpwgeavSPEEIAEALEQHDikavtL 130
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6321904 141 VHLESPVnpyGTSSDIESLARRAHAKGALLIVD--STFASPPLQY-AWnfGADIVLYSATKYFG 201
Cdd:cd06451 131 THNETST---GVLNPLEGIGALAKKHDALLIVDavSSLGGEPFRMdEW--GVDVAYTGSQKALG 189
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
79-262 |
7.01e-03 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 38.06 E-value: 7.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 79 AVIYSSGLAA--FYAAMVHYNPK-KIFIGQSYHGvrAIANILtRNYGIEQH--PLEDIEKCasEGDIVHLE--------- 144
Cdd:pfam00155 65 AVVFGSGAGAniEALIFLLANPGdAILVPAPTYA--SYIRIA-RLAGGEVVryPLYDSNDF--HLDFDALEaalkekpkv 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321904 145 ----SPVNPYGTS---SDIESLARRAHAKGALLIVDSTFA-----SPPLQYAWNFGAD----IVLYSATKYFG--GhsdL 206
Cdd:pfam00155 140 vlhtSPHNPTGTVatlEELEKLLDLAKEHNILLLVDEAYAgfvfgSPDAVATRALLAEgpnlLVVGSFSKAFGlaG---W 216
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 6321904 207 LSGVLVVKEEATSRQLKDDRIYLGTNVAnleSFMLLRSLRTYEMRITKQSENATKL 262
Cdd:pfam00155 217 RVGYILGNAAVISQLRKLARPFYSSTHL---QAAAAAALSDPLLVASELEEMRQRI 269
|
|
| |
