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Conserved domains on  [gi|6321910|ref|NP_011986|]
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origin recognition complex subunit 6 [Saccharomyces cerevisiae S288C]

Protein Classification

Orc6_mid domain-containing protein( domain architecture ID 10527205)

Orc6_mid domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ORC6 pfam05460
Origin recognition complex subunit 6 (ORC6); This family consists of several eukaryotic origin ...
22-416 1.44e-82

Origin recognition complex subunit 6 (ORC6); This family consists of several eukaryotic origin recognition complex subunit 6 (ORC6) proteins. Despite differences in their structure and sequences among eukaryotic replicators, ORC is a conserved feature of replication initiation in all eukaryotes. ORC-related genes have been identified in organizms ranging from S. pombe to plants to humans. All DNA replication initiation is driven by a single conserved eukaryotic initiator complex termed he origin recognition complex (ORC). The ORC is a six protein complex. The function of ORC is reviewed in.


:

Pssm-ID: 368452 [Multi-domain]  Cd Length: 288  Bit Score: 255.66  E-value: 1.44e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321910     22 PDWSSGYLKKLTNATSILYNTSL-NKVMLKQDEEVARCHICAYIASQKMNEKHmpDLCYYIDSIPLEPKKAKHLMNLFRQ 100
Cdd:pfam05460   6 PTLGLGYPKKLLSKASELYRLSLvKKVMLKNNEEIARCHICAELAAEKLSIKL--DLPYAVKLIPLPPKAYAKLLDTFRN 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321910    101 SLSNSSPmkqfawTPSpkknkrspvknggrftssdpkelrnqlfgTPTKVRKSQNNdsfvipelppmqtneSPSiTRRKL 180
Cdd:pfam05460  84 SLGNQSP------TPS-----------------------------TPTKSKTSKTN---------------SPL-KRRKL 112
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321910    181 AFeedededeeepgndglslkshsnksitgtrnvDSDEYENHESDPTSEEEPLGVQesrsgrtKQNKAVGKPQSELktak 260
Cdd:pfam05460 113 AF--------------------------------EEDGEEGSPSIPLNDESILFND-------DDDKKSAQKSPRL---- 149
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321910    261 alrkrgripnslLVKKYCKMTTEEIIRLCNDFELPREVAYKIVDEYNINASRLVCPWQLVCGLVLNCTFIVFNERRRKDP 340
Cdd:pfam05460 150 ------------LKKKKDKISIADIIELCNQFGLPAEVTVSALEGFLAYKRKFLKPWQLACGLVLAAYFRINHRLLRQTP 217
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6321910    341 RIDHFIVSkmcslMLTSKVDDVIECVKLVKELIIGEKWFRDLQIRYDDFDGIRYDEIIFRKLGSMLQTTNILVTDD 416
Cdd:pfam05460 218 GIDSGFPS-----LGGLQREDVDLWIPIVEEWIKGEEWFREIEIKYDYFDGAEEEESIAKGLGSMIQAAADYLSEK 288
 
Name Accession Description Interval E-value
ORC6 pfam05460
Origin recognition complex subunit 6 (ORC6); This family consists of several eukaryotic origin ...
22-416 1.44e-82

Origin recognition complex subunit 6 (ORC6); This family consists of several eukaryotic origin recognition complex subunit 6 (ORC6) proteins. Despite differences in their structure and sequences among eukaryotic replicators, ORC is a conserved feature of replication initiation in all eukaryotes. ORC-related genes have been identified in organizms ranging from S. pombe to plants to humans. All DNA replication initiation is driven by a single conserved eukaryotic initiator complex termed he origin recognition complex (ORC). The ORC is a six protein complex. The function of ORC is reviewed in.


Pssm-ID: 368452 [Multi-domain]  Cd Length: 288  Bit Score: 255.66  E-value: 1.44e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321910     22 PDWSSGYLKKLTNATSILYNTSL-NKVMLKQDEEVARCHICAYIASQKMNEKHmpDLCYYIDSIPLEPKKAKHLMNLFRQ 100
Cdd:pfam05460   6 PTLGLGYPKKLLSKASELYRLSLvKKVMLKNNEEIARCHICAELAAEKLSIKL--DLPYAVKLIPLPPKAYAKLLDTFRN 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321910    101 SLSNSSPmkqfawTPSpkknkrspvknggrftssdpkelrnqlfgTPTKVRKSQNNdsfvipelppmqtneSPSiTRRKL 180
Cdd:pfam05460  84 SLGNQSP------TPS-----------------------------TPTKSKTSKTN---------------SPL-KRRKL 112
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321910    181 AFeedededeeepgndglslkshsnksitgtrnvDSDEYENHESDPTSEEEPLGVQesrsgrtKQNKAVGKPQSELktak 260
Cdd:pfam05460 113 AF--------------------------------EEDGEEGSPSIPLNDESILFND-------DDDKKSAQKSPRL---- 149
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321910    261 alrkrgripnslLVKKYCKMTTEEIIRLCNDFELPREVAYKIVDEYNINASRLVCPWQLVCGLVLNCTFIVFNERRRKDP 340
Cdd:pfam05460 150 ------------LKKKKDKISIADIIELCNQFGLPAEVTVSALEGFLAYKRKFLKPWQLACGLVLAAYFRINHRLLRQTP 217
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6321910    341 RIDHFIVSkmcslMLTSKVDDVIECVKLVKELIIGEKWFRDLQIRYDDFDGIRYDEIIFRKLGSMLQTTNILVTDD 416
Cdd:pfam05460 218 GIDSGFPS-----LGGLQREDVDLWIPIVEEWIKGEEWFREIEIKYDYFDGAEEEESIAKGLGSMIQAAADYLSEK 288
Orc6_mid cd11583
Middle domain of the origin recognition complex subunit 6; Orc6 is a subunit of the origin ...
265-356 6.15e-19

Middle domain of the origin recognition complex subunit 6; Orc6 is a subunit of the origin recognition complex in eukaryotes, and it may be involved in binding to DNA. This model describes the central or middle domain of Orc6, whose structure resembles that of TFIIB, a DNA-binding transcription factor. Orc6 appears to form distinct complexes with DNA, and a putative DNA-binding site has been identified.


Pssm-ID: 211425  Cd Length: 94  Bit Score: 81.19  E-value: 6.15e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321910  265 RGRIPNSLLVKKYCKMTTEEIIRLCNDFELP------REVAYKIVDEYNINASRLVCPWQLVCGLVLNCTFIVfnerrRK 338
Cdd:cd11583   1 SRLSVRDLAVQFGCKEAIEEAEKLLNRYKLPflaseqRRVADFSLPQFTAAAFYLACKKLKVKVDKSKLLEVS-----GV 75
                        90
                ....*....|....*...
gi 6321910  339 DPRIDHFIVSKMCSLMLT 356
Cdd:cd11583  76 DPSIFDRLCASMEKLCKD 93
 
Name Accession Description Interval E-value
ORC6 pfam05460
Origin recognition complex subunit 6 (ORC6); This family consists of several eukaryotic origin ...
22-416 1.44e-82

Origin recognition complex subunit 6 (ORC6); This family consists of several eukaryotic origin recognition complex subunit 6 (ORC6) proteins. Despite differences in their structure and sequences among eukaryotic replicators, ORC is a conserved feature of replication initiation in all eukaryotes. ORC-related genes have been identified in organizms ranging from S. pombe to plants to humans. All DNA replication initiation is driven by a single conserved eukaryotic initiator complex termed he origin recognition complex (ORC). The ORC is a six protein complex. The function of ORC is reviewed in.


Pssm-ID: 368452 [Multi-domain]  Cd Length: 288  Bit Score: 255.66  E-value: 1.44e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321910     22 PDWSSGYLKKLTNATSILYNTSL-NKVMLKQDEEVARCHICAYIASQKMNEKHmpDLCYYIDSIPLEPKKAKHLMNLFRQ 100
Cdd:pfam05460   6 PTLGLGYPKKLLSKASELYRLSLvKKVMLKNNEEIARCHICAELAAEKLSIKL--DLPYAVKLIPLPPKAYAKLLDTFRN 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321910    101 SLSNSSPmkqfawTPSpkknkrspvknggrftssdpkelrnqlfgTPTKVRKSQNNdsfvipelppmqtneSPSiTRRKL 180
Cdd:pfam05460  84 SLGNQSP------TPS-----------------------------TPTKSKTSKTN---------------SPL-KRRKL 112
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321910    181 AFeedededeeepgndglslkshsnksitgtrnvDSDEYENHESDPTSEEEPLGVQesrsgrtKQNKAVGKPQSELktak 260
Cdd:pfam05460 113 AF--------------------------------EEDGEEGSPSIPLNDESILFND-------DDDKKSAQKSPRL---- 149
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321910    261 alrkrgripnslLVKKYCKMTTEEIIRLCNDFELPREVAYKIVDEYNINASRLVCPWQLVCGLVLNCTFIVFNERRRKDP 340
Cdd:pfam05460 150 ------------LKKKKDKISIADIIELCNQFGLPAEVTVSALEGFLAYKRKFLKPWQLACGLVLAAYFRINHRLLRQTP 217
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6321910    341 RIDHFIVSkmcslMLTSKVDDVIECVKLVKELIIGEKWFRDLQIRYDDFDGIRYDEIIFRKLGSMLQTTNILVTDD 416
Cdd:pfam05460 218 GIDSGFPS-----LGGLQREDVDLWIPIVEEWIKGEEWFREIEIKYDYFDGAEEEESIAKGLGSMIQAAADYLSEK 288
Orc6_mid cd11583
Middle domain of the origin recognition complex subunit 6; Orc6 is a subunit of the origin ...
265-356 6.15e-19

Middle domain of the origin recognition complex subunit 6; Orc6 is a subunit of the origin recognition complex in eukaryotes, and it may be involved in binding to DNA. This model describes the central or middle domain of Orc6, whose structure resembles that of TFIIB, a DNA-binding transcription factor. Orc6 appears to form distinct complexes with DNA, and a putative DNA-binding site has been identified.


Pssm-ID: 211425  Cd Length: 94  Bit Score: 81.19  E-value: 6.15e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321910  265 RGRIPNSLLVKKYCKMTTEEIIRLCNDFELP------REVAYKIVDEYNINASRLVCPWQLVCGLVLNCTFIVfnerrRK 338
Cdd:cd11583   1 SRLSVRDLAVQFGCKEAIEEAEKLLNRYKLPflaseqRRVADFSLPQFTAAAFYLACKKLKVKVDKSKLLEVS-----GV 75
                        90
                ....*....|....*...
gi 6321910  339 DPRIDHFIVSKMCSLMLT 356
Cdd:cd11583  76 DPSIFDRLCASMEKLCKD 93
ORC6_CTD cd16075
C-terminal domain of the eukaryotic origin recognition complex subunit ORC6; In eukaryotes, a ...
377-434 5.56e-07

C-terminal domain of the eukaryotic origin recognition complex subunit ORC6; In eukaryotes, a complex consisting of six subunits promotes the onset of DNA replication. The 6th subunit, ORC6, does not belong to the wider AAA+ family of nucleotide hydrolases, but contains a tandemly repeated domain resembling the transcription factor TFIIB, as well as this C-terminal domain which harbors a helical segment that is responsible for interactions with the complex by binding to ORC3. Mutations in this C-terminal helix interfere with the formation of the ORC and have been linked to Meier-Gorlin syndrome, a dwarfism disorder.


Pssm-ID: 293922  Cd Length: 53  Bit Score: 46.18  E-value: 5.56e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6321910  377 KWFRDLQIRYddFDGIRYDEIIFRklgSMLQTTNIlVTDDQYNIWKKRIEMDLALTEP 434
Cdd:cd16075   1 KRQKTLKERY--FEEKEKEEEVER---SKQQKSEK-ETIEDYEEWKRRILENAAKALK 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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