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Conserved domains on  [gi|6321960|ref|NP_012036|]
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anaphase promoting complex subunit CDC23 [Saccharomyces cerevisiae S288C]

Protein Classification

ANAPC8 and TPR domain-containing protein( domain architecture ID 12049631)

ANAPC8 and TPR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANAPC8 pfam04049
Anaphase promoting complex subunit 8 / Cdc23; The anaphase-promoting complex is composed of ...
 12-144 5.35e-34

Anaphase promoting complex subunit 8 / Cdc23; The anaphase-promoting complex is composed of eight protein subunits, including BimE (APC1), CDC27 (APC3), CDC16 (APC6), and CDC23 (APC8).


:

Pssm-ID: 427675  Cd Length: 140  Bit Score: 126.17  E-value: 5.35e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960     12 DIRIQLRKAATELSRWKLYGSSKW-----AAEALAGLAEAIDVDQTHSLADESPLRNKQGVPKqmfeiPQNgFGLSETEY 86
Cdd:pfam04049   1 ELRAELRQAVVKCSERCLYQSAKWaaellNGLPPPDDDDDPSDTDPDSPMSESPLPARTPNPD-----PEE-ARLEAKEY 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 6321960     87 DLYLLGSTLFDAKEFDRCVFFLKDVTNPYLKFLKLYSKFLSWDKKSQESMENILTTGK 144
Cdd:pfam04049  75 DKYLLAKSYFDCKEFDRCAAVLKDCKSQKSLFLALYAKYLAGEKRKEEESEMVLGPQD 132
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
391-554 2.00e-23

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 99.70  E-value: 2.00e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  391 QIDRFRPETCCIIANYYSARQEHEKSIMYFRRALTLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICPRDFKAWFG 470
Cdd:COG0457   2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  471 LGQAYALLDMHLYSLYYFQKACTLKPWDRRIWQVLGECYSKTGNKVEAIKCYKRSIKASqtvDQNTSIYYRLAQLYEELE 550
Cdd:COG0457  82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELD---PDDADALYNLGIALEKLG 158


                ....
gi 6321960  551 DLQE 554
Cdd:COG0457 159 RYEE 162
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 306-427 7.71e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.09  E-value: 7.71e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  306 ELNGQLEDYFEDLEFLLQVFPNFTFLKAYNATISYNNLDYVTAESRFDDIVKQDPyrlNDLETYSNILYVMQKNSK---- 381
Cdd:COG4783  15 LLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDP---DEPEARLNLGLALLKAGDydea 91

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 6321960  382 LAYLAQFVsQIDRFRPETCCIIANYYSARQEHEKSIMYFRRALTLD 427
Cdd:COG4783  92 LALLEKAL-KLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
 
Name Accession Description Interval E-value
ANAPC8 pfam04049
Anaphase promoting complex subunit 8 / Cdc23; The anaphase-promoting complex is composed of ...
 12-144 5.35e-34

Anaphase promoting complex subunit 8 / Cdc23; The anaphase-promoting complex is composed of eight protein subunits, including BimE (APC1), CDC27 (APC3), CDC16 (APC6), and CDC23 (APC8).


Pssm-ID: 427675  Cd Length: 140  Bit Score: 126.17  E-value: 5.35e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960     12 DIRIQLRKAATELSRWKLYGSSKW-----AAEALAGLAEAIDVDQTHSLADESPLRNKQGVPKqmfeiPQNgFGLSETEY 86
Cdd:pfam04049   1 ELRAELRQAVVKCSERCLYQSAKWaaellNGLPPPDDDDDPSDTDPDSPMSESPLPARTPNPD-----PEE-ARLEAKEY 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 6321960     87 DLYLLGSTLFDAKEFDRCVFFLKDVTNPYLKFLKLYSKFLSWDKKSQESMENILTTGK 144
Cdd:pfam04049  75 DKYLLAKSYFDCKEFDRCAAVLKDCKSQKSLFLALYAKYLAGEKRKEEESEMVLGPQD 132
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
391-554 2.00e-23

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 99.70  E-value: 2.00e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  391 QIDRFRPETCCIIANYYSARQEHEKSIMYFRRALTLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICPRDFKAWFG 470
Cdd:COG0457   2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  471 LGQAYALLDMHLYSLYYFQKACTLKPWDRRIWQVLGECYSKTGNKVEAIKCYKRSIKASqtvDQNTSIYYRLAQLYEELE 550
Cdd:COG0457  82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELD---PDDADALYNLGIALEKLG 158


                ....
gi 6321960  551 DLQE 554
Cdd:COG0457 159 RYEE 162
TPR_11 pfam13414
TPR repeat;
438-478 3.30e-05

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 41.30  E-value: 3.30e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 6321960    438 GHEFVELSNSHAAIECYRRAVDICPRDFKAWFGLGQAYALL 478
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKL 41
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 316-554 4.23e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.62  E-value: 4.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960    316 EDLEFLLQVFPNFTFLKAYNATISY--NNLDyvTAESRFDDIVKQDPYRLNDLETYSNiLYVMQKNSKLAylAQFVSQID 393
Cdd:TIGR02917 486 EAFEKALSIEPDFFPAAANLARIDIqeGNPD--DAIQRFEKVLTIDPKNLRAILALAG-LYLRTGNEEEA--VAWLEKAA 560

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960    394 RFRP---ETCCIIANYYSARQEHEKSIMYFRRALTLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICPRDFKAWFG 470
Cdd:TIGR02917 561 ELNPqeiEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLL 640

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960    471 LGQAYALLDMHLYSLYYFQKACTLKPWDRRIWQVLGECYSKTGNKVEAIKCYKRSIKASQTVDQNTSIyyrLAQLYEELE 550
Cdd:TIGR02917 641 LADAYAVMKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFEL---EGDLYLRQK 717


                  ....
gi 6321960    551 DLQE 554
Cdd:TIGR02917 718 DYPA 721
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 409-494 1.47e-04

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 44.16  E-value: 1.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  409 ARQEHEKSIMYFRRALTLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICP-RDFKAWFGLGQAYALLDmhlySLYY 487
Cdd:cd24142  12 DQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPdGGYEKYLYLGQLSGGEE----ALQY 87


                ....*..
gi 6321960  488 FQKACTL 494
Cdd:cd24142  88 YEKGIEI 94
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 306-427 7.71e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.09  E-value: 7.71e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  306 ELNGQLEDYFEDLEFLLQVFPNFTFLKAYNATISYNNLDYVTAESRFDDIVKQDPyrlNDLETYSNILYVMQKNSK---- 381
Cdd:COG4783  15 LLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDP---DEPEARLNLGLALLKAGDydea 91

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 6321960  382 LAYLAQFVsQIDRFRPETCCIIANYYSARQEHEKSIMYFRRALTLD 427
Cdd:COG4783  92 LALLEKAL-KLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
 
Name Accession Description Interval E-value
ANAPC8 pfam04049
Anaphase promoting complex subunit 8 / Cdc23; The anaphase-promoting complex is composed of ...
 12-144 5.35e-34

Anaphase promoting complex subunit 8 / Cdc23; The anaphase-promoting complex is composed of eight protein subunits, including BimE (APC1), CDC27 (APC3), CDC16 (APC6), and CDC23 (APC8).


Pssm-ID: 427675  Cd Length: 140  Bit Score: 126.17  E-value: 5.35e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960     12 DIRIQLRKAATELSRWKLYGSSKW-----AAEALAGLAEAIDVDQTHSLADESPLRNKQGVPKqmfeiPQNgFGLSETEY 86
Cdd:pfam04049   1 ELRAELRQAVVKCSERCLYQSAKWaaellNGLPPPDDDDDPSDTDPDSPMSESPLPARTPNPD-----PEE-ARLEAKEY 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 6321960     87 DLYLLGSTLFDAKEFDRCVFFLKDVTNPYLKFLKLYSKFLSWDKKSQESMENILTTGK 144
Cdd:pfam04049  75 DKYLLAKSYFDCKEFDRCAAVLKDCKSQKSLFLALYAKYLAGEKRKEEESEMVLGPQD 132
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
391-554 2.00e-23

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 99.70  E-value: 2.00e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  391 QIDRFRPETCCIIANYYSARQEHEKSIMYFRRALTLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICPRDFKAWFG 470
Cdd:COG0457   2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  471 LGQAYALLDMHLYSLYYFQKACTLKPWDRRIWQVLGECYSKTGNKVEAIKCYKRSIKASqtvDQNTSIYYRLAQLYEELE 550
Cdd:COG0457  82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELD---PDDADALYNLGIALEKLG 158


                ....
gi 6321960  551 DLQE 554
Cdd:COG0457 159 RYEE 162
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 348-601 1.77e-19

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 89.02  E-value: 1.77e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  348 AESRFDDIVKQDPyrlNDLETYSNI--LYVMQKNSKLA-YLAQFVSQIDRFRPETCCIIANYYSARQEHEKSIMYFRRAL 424
Cdd:COG2956  27 AIDLLEEALELDP---ETVEAHLALgnLYRRRGEYDRAiRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLL 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  425 TLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICPRDFKAWFGLGQAYALLDMHLYSLYYFQKACTLKPWDRRIWQV 504
Cdd:COG2956 104 ELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLL 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  505 LGECYSKTGNKVEAIKCYKRSIKASqtvDQNTSIYYRLAQLYEELEDLQECKKFMMKCVDveellegivTDETVKARLWL 584
Cdd:COG2956 184 LAELYLEQGDYEEAIAALERALEQD---PDYLPALPRLAELYEKLGDPEEALELLRKALE---------LDPSDDLLLAL 251

                       250
                ....*....|....*..
gi 6321960  585 AIFEIKAGNYQLAYDYA 601
Cdd:COG2956 252 ADLLERKEGLEAALALL 268
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
391-553 1.77e-19

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 88.14  E-value: 1.77e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  391 QIDRFRPETCCIIANYYSARQEHEKSIMYFRRALTLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICPRDFKAWFG 470
Cdd:COG0457  36 ELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYN 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  471 LGQAYALLDMHLYSLYYFQKACTLKPWDRRIWQVLGECYSKTGNKVEAIKCYKRSIKASQTVDQNTSIYYRLAQLYEELE 550
Cdd:COG0457 116 LGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEV 195


                ...
gi 6321960  551 DLQ 553
Cdd:COG0457 196 LLA 198
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 404-600 6.29e-18

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 84.40  E-value: 6.29e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  404 ANYYSARQEHEKSIMYFRRALTLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICPRDFKAWFGLGQAYALLDMHLY 483
Cdd:COG2956  15 GLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDR 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  484 SLYYFQKACTLKPWDRRIWQVLGECYSKTGNKVEAIKCYKRSIKASqtvDQNTSIYYRLAQLYEELEDLQECKKFMmkcv 563
Cdd:COG2956  95 AEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLG---PENAHAYCELAELYLEQGDYDEAIEAL---- 167

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 6321960  564 dvEELLEgiVTDETVKARLWLAIFEIKAGNYQLAYDY 600
Cdd:COG2956 168 --EKALK--LDPDCARALLLLAELYLEQGDYEEAIAA 200
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
424-600 8.34e-18

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 83.13  E-value: 8.34e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  424 LTLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICPRDFKAWFGLGQAYALLDMHLYSLYYFQKACTLKPWDRRIWQ 503
Cdd:COG0457   1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  504 VLGECYSKTGNKVEAIKCYKRSIKASqtvDQNTSIYYRLAQLYEELEDLQECKKFMMKCVDVEEllegivtdETVKARLW 583
Cdd:COG0457  81 NLGLALQALGRYEEALEDYDKALELD---PDDAEALYNLGLALLELGRYDEAIEAYERALELDP--------DDADALYN 149

                       170
                ....*....|....*..
gi 6321960  584 LAIFEIKAGNYQLAYDY 600
Cdd:COG0457 150 LGIALEKLGRYEEALEL 166
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 404-569 8.99e-15

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 77.73  E-value: 8.99e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  404 ANYYSARQEHEKSIMYFRRALTLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICPRDFKAWFGLGQAYALLDMHLY 483
Cdd:COG3914  85 ALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEE 164

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  484 SLYYFQKACTLKPWDRRIWQVLGECYSKTGNKVEAIKCYKRSIKASQTVDQNTSIYYRLAQLYEELEDLQECKKFMMKCV 563
Cdd:COG3914 165 AIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDRFEELLAALA 244


                ....*.
gi 6321960  564 DVEELL 569
Cdd:COG3914 245 RGPSEL 250
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 403-529 2.24e-14

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 70.61  E-value: 2.24e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  403 IANYYSARQEHEKSIMYFRRALTLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICPRDFKAWFGLGQAYALLDMHL 482
Cdd:COG4783  10 LAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYD 89

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 6321960  483 YSLYYFQKACTLKPWDRRIWQVLGECYSKTGNKVEAIKCYKRSIKAS 529
Cdd:COG4783  90 EALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 433-554 1.17e-12

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 65.60  E-value: 1.17e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  433 AWTLMGHEFVELSNSHAAIECYRRAVDICPRDFKAWFGLGQAYALLDMHLYSLYYFQKACTLKPWDRRIWQVLGECYSKT 512
Cdd:COG4783   6 ALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKA 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 6321960  513 GNKVEAIKCYKRSIKASQtvdQNTSIYYRLAQLYEELEDLQE 554
Cdd:COG4783  86 GDYDEALALLEKALKLDP---EHPEAYLRLARAYRALGRPDE 124
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 344-528 8.46e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 65.91  E-value: 8.46e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  344 DYVTAESRFDDIVKQDPYRLNDLETYSNIlYVMQKNSKLAY-LAQFVSQIDRFRPETCCIIANYYSARQEHEKSIMYFRR 422
Cdd:COG2956  91 LLDRAEELLEKLLELDPDDAEALRLLAEI-YEQEGDWEKAIeVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEK 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  423 ALTLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICPRDFKAWFGLGQAYALLDMHLYSLYYFQKACTLKPwDRRIW 502
Cdd:COG2956 170 ALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDP-SDDLL 248

                       170       180
                ....*....|....*....|....*.
gi 6321960  503 QVLGECYSKTGNKVEAIKCYKRSIKA 528
Cdd:COG2956 249 LALADLLERKEGLEAALALLERQLRR 274
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 397-557 1.32e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 67.71  E-value: 1.32e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  397 PETCCIIANYYSARQEHEKSIMYFRRALTLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICPRDFKAWFGLGQAYA 476
Cdd:COG3914 112 AEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQ 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  477 LLDMHLYSLYYFQKACTLKPWDRRIWQVLGECYSKTGnkveAIKCYKRSIKASQTVDQNTSIYYRLAQLYEELEDLQECK 556
Cdd:COG3914 192 DLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQAC----DWEVYDRFEELLAALARGPSELSPFALLYLPDDDPAELL 267


                .
gi 6321960  557 K 557
Cdd:COG3914 268 A 268
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 417-545 1.88e-11

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 61.95  E-value: 1.88e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  417 IMYFRRALTLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICPRDFKAWFGLGQAYALLDMHLYSLYYFQKACTLKP 496
Cdd:COG4235   3 IARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDP 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 6321960  497 WDRRIWQVLGECYSKTGNKVEAIKCYKRSIKASQTVDQNTSIYYRLAQL 545
Cdd:COG4235  83 DNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARLLEASIAEA 131
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 449-554 1.94e-11

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 61.95  E-value: 1.94e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  449 AAIECYRRAVDICPRDFKAWFGLGQAYALLDMHLYSLYYFQKACTLKPWDRRIWQVLGECYSKTGNKVEAIKCYKRSIKA 528
Cdd:COG4235   1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80

                        90       100
                ....*....|....*....|....*.
gi 6321960  529 SqtvDQNTSIYYRLAQLYEELEDLQE 554
Cdd:COG4235  81 D---PDNPEALYLLGLAAFQQGDYAE 103
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 441-529 2.70e-10

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 59.20  E-value: 2.70e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  441 FVELSNSHAAIECYRRAVDICPRDFKAWFGLGQAYALLDMHLYSLYYFQKACTLKPWDRRIWQVLGECYSKTGNKVEAIK 520
Cdd:COG5010  64 YNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKA 143


                ....*....
gi 6321960  521 CYKRSIKAS 529
Cdd:COG5010 144 ALQRALGTS 152
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 434-600 4.17e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.90  E-value: 4.17e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  434 WTLMGHEFVELSNSHAAIECYRRAVDICPRDFKAWFGLGQAYALLDMHLYSLYYFQKACTLKPWDRRIWQVLGECYSKTG 513
Cdd:COG2956  11 WYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAG 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  514 NKVEAIKCYKrsiKASQTVDQNTSIYYRLAQLYEELEDLQECKKFmmkcvdVEELLEgiVTDETVKARLWLAIFEIKAGN 593
Cdd:COG2956  91 LLDRAEELLE---KLLELDPDDAEALRLLAEIYEQEGDWEKAIEV------LERLLK--LGPENAHAYCELAELYLEQGD 159


                ....*..
gi 6321960  594 YQLAYDY 600
Cdd:COG2956 160 YDEAIEA 166
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 403-504 2.69e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 55.78  E-value: 2.69e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  403 IANYYSARQEHEKSIMYFRRALTLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICPRDFKAWFGLGQAYALLDMHL 482
Cdd:COG4235  23 LGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYA 102

                        90       100
                ....*....|....*....|..
gi 6321960  483 YSLYYFQKACTLKPWDRRIWQV 504
Cdd:COG4235 103 EAIAAWQKLLALLPADAPARLL 124
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 358-496 6.16e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 55.35  E-value: 6.16e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  358 QDPYRLNDLETYSNILYVMQKNSKLAYLAQFVSQIDRFRPETCCIIANYYSARQEHEKSIMYFRRALTLDKKTTNAWTLM 437
Cdd:COG5010  15 LLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNL 94

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 6321960  438 GHEFVELSNSHAAIECYRRAVDICPRDFKAWFGLGQAYALLDMHLYSLYYFQKACTLKP 496
Cdd:COG5010  95 ALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 401-498 7.21e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.81  E-value: 7.21e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  401 CIIANYYSARQEHEKSIMYFRRALTLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICPRDFKAWFGLGQAYALLDM 480
Cdd:COG4783  42 ALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGR 121

                        90
                ....*....|....*...
gi 6321960  481 HLYSLYYFQKACTLKPWD 498
Cdd:COG4783 122 PDEAIAALEKALELDPDD 139
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
406-500 3.59e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 51.32  E-value: 3.59e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  406 YYSARQEHEKSIMYFRRALTLDKKTTNAWTLMGHEFVELSNSHAAIEcYRRAVDICPRDFKAWFGLGQAYALLDMHLYSL 485
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEAL 79

                        90
                ....*....|....*
gi 6321960  486 YYFQKACTLKPWDRR 500
Cdd:COG3063  80 AYLERALELDPSALR 94
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 488-600 2.52e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 50.00  E-value: 2.52e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  488 FQKACTLKPWDRRIWQVLGECYSKTGNKVEAIKCYKRSIKASqtvDQNTSIYYRLAQLYEELEDLQEckkfmmkcvdVEE 567
Cdd:COG4235   6 LRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLD---PDNADALLDLAEALLAAGDTEE----------AEE 72

                        90       100       110
                ....*....|....*....|....*....|....*
gi 6321960  568 LLEGIVT--DETVKARLWLAIFEIKAGNYQLAYDY 600
Cdd:COG4235  73 LLERALAldPDNPEALYLLGLAAFQQGDYAEAIAA 107
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 474-554 1.20e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 48.80  E-value: 1.20e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  474 AYALLDMHLYSLYYFQKACTLKPWDRRIWQVLGECYSKTGNKVEAIKCYKRSIKASQtvdQNTSIYYRLAQLYEELEDLQ 553
Cdd:COG5010  63 LYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSP---DNPNAYSNLAALLLSLGQDD 139


                .
gi 6321960  554 E 554
Cdd:COG5010 140 E 140
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
404-527 1.25e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 49.91  E-value: 1.25e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  404 ANYYSARQEHEKSIMYFRRALTLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICPRDFKAWFGLGqaYALLDMHLY 483
Cdd:COG4785  80 GVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRG--IALYYLGRY 157

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6321960  484 SLYY--FQKACTLKPWDRRIWQVLGECYSKT--------------------GNKVEAIKCYKRSIK 527
Cdd:COG4785 158 ELAIadLEKALELDPNDPERALWLYLAERKLdpekalallledwatayllqGDTEEARELFKLALA 223
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
449-529 1.86e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 46.32  E-value: 1.86e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  449 AAIECYRRAVDICPRDFKAWFGLGQAYALLDMHLYSLYyFQKACTLKPWDRRIWQVLGECYSKTGNKVEAIKCYKRSIKA 528
Cdd:COG3063  10 EAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALEL 88


                .
gi 6321960  529 S 529
Cdd:COG3063  89 D 89
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 467-601 3.55e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 46.72  E-value: 3.55e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  467 AWFGLGQAYALLDMHLYSLYYFQKACTLKPWDRRIWQVLGECYSKTGNKVEAIKCYKRSIKASQtvdQNTSIYYRLAQLY 546
Cdd:COG4783   6 ALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDP---DEPEARLNLGLAL 82

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 6321960  547 EELEDLQECKKFMMKCVDVEEllegivtdETVKARLWLAIFEIKAGNYQLAYDYA 601
Cdd:COG4783  83 LKAGDYDEALALLEKALKLDP--------EHPEAYLRLARAYRALGRPDEAIAAL 129
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 438-601 7.23e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 49.22  E-value: 7.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  438 GHEFVELSNSHAAIECYRRAVDICPRDFKAWFGLGQAYALLdmhlyslyyfqkactlkpwdrriwqvlgecysktGNKVE 517
Cdd:COG3914  85 ALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLAL----------------------------------GRLEE 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  518 AIKCYKRSIKASqtvDQNTSIYYRLAQLYEELEDLQECKKFMMKCVDVEEllegivtdETVKARLWLAIFEIKAGNYQLA 597
Cdd:COG3914 131 ALAALRRALALN---PDFAEAYLNLGEALRRLGRLEEAIAALRRALELDP--------DNAEALNNLGNALQDLGRLEEA 199


                ....
gi 6321960  598 YDYA 601
Cdd:COG3914 200 IAAY 203
TPR_11 pfam13414
TPR repeat;
438-478 3.30e-05

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 41.30  E-value: 3.30e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 6321960    438 GHEFVELSNSHAAIECYRRAVDICPRDFKAWFGLGQAYALL 478
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKL 41
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 316-554 4.23e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.62  E-value: 4.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960    316 EDLEFLLQVFPNFTFLKAYNATISY--NNLDyvTAESRFDDIVKQDPYRLNDLETYSNiLYVMQKNSKLAylAQFVSQID 393
Cdd:TIGR02917 486 EAFEKALSIEPDFFPAAANLARIDIqeGNPD--DAIQRFEKVLTIDPKNLRAILALAG-LYLRTGNEEEA--VAWLEKAA 560

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960    394 RFRP---ETCCIIANYYSARQEHEKSIMYFRRALTLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICPRDFKAWFG 470
Cdd:TIGR02917 561 ELNPqeiEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLL 640

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960    471 LGQAYALLDMHLYSLYYFQKACTLKPWDRRIWQVLGECYSKTGNKVEAIKCYKRSIKASQTVDQNTSIyyrLAQLYEELE 550
Cdd:TIGR02917 641 LADAYAVMKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFEL---EGDLYLRQK 717


                  ....
gi 6321960    551 DLQE 554
Cdd:TIGR02917 718 DYPA 721
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
487-566 6.32e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 42.08  E-value: 6.32e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  487 YFQKACTLKPWDRRIWQVLGECYSKTGNKVEAIKcYKRSIKASQtvdQNTSIYYRLAQLYEELEDLQECKKFMMKCVDVE 566
Cdd:COG3063  14 YYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDP---NNAEALLNLAELLLELGDYDEALAYLERALELD 89
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 336-464 1.11e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.49  E-value: 1.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  336 ATISYNNLDYVTAESRFDDIVKQDPYRLNDLETYSNILYVMQKNSKLAYLAQFVSQIDRFRPETCCIIANYYSARQEHEK 415
Cdd:COG4783  11 AQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDE 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 6321960  416 SIMYFRRALTLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICPRD 464
Cdd:COG4783  91 ALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 409-494 1.47e-04

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 44.16  E-value: 1.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  409 ARQEHEKSIMYFRRALTLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICP-RDFKAWFGLGQAYALLDmhlySLYY 487
Cdd:cd24142  12 DQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPdGGYEKYLYLGQLSGGEE----ALQY 87


                ....*..
gi 6321960  488 FQKACTL 494
Cdd:cd24142  88 YEKGIEI 94
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
309-486 2.95e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.07  E-value: 2.95e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  309 GQLEDYFEDLEFLLQVFPNFtfLKAYN--ATISYNNLDYVTAESRFDDIVKQDPyrlNDLETYSNI--LYVMQKNSKLAy 384
Cdd:COG0457  22 GRYEEAIEDYEKALELDPDD--AEALYnlGLAYLRLGRYEEALADYEQALELDP---DDAEALNNLglALQALGRYEEA- 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  385 LAQF--VSQIDRFRPETCCIIANYYSARQEHEKSIMYFRRALTLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICP 462
Cdd:COG0457  96 LEDYdkALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAAL 175

                       170       180
                ....*....|....*....|....
gi 6321960  463 RDFKAWFGLGQAYALLDMHLYSLY 486
Cdd:COG0457 176 AALLAAALGEAALALAAAEVLLAL 199
LcrH_SycD TIGR02552
type III secretion low calcium response chaperone LcrH/SycD; Genes in this family are found in ...
 462-549 9.81e-04

type III secretion low calcium response chaperone LcrH/SycD; Genes in this family are found in type III secretion operons. LcrH, from Yersinia is believed to have a regulatory function in the low-calcium response of the secretion system. The same protein is also known as SycD (SYC = Specific Yop Chaperone) for its chaperone role. In Pseudomonas, where the homolog is known as PcrH, the chaperone role has been demonstrated and the regulatory role appears to be absent. ScyD/LcrH contains three central tetratricopeptide-like repeats that are predicted to fold into an all-alpha-helical array.


Pssm-ID: 274197 [Multi-domain]  Cd Length: 135  Bit Score: 39.58  E-value: 9.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960    462 PRDFKAWFGLGQAYALLDMHLYSLYYFQKACTLKPWDRRIWQVLGECYSKTGNKVEAIKCYKRSIKASQTVDQNTSIYYR 541
Cdd:TIGR02552  48 PYNSRYWLGLAACCQMLKEYEEAIDAYALAAALDPDDPRPYFHAAECLLALGEPESALKALDLAIEICGENPEYSELKER 127


                  ....*...
gi 6321960    542 LAQLYEEL 549
Cdd:TIGR02552 128 AEAMLESL 135
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 471-553 1.21e-03

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 41.46  E-value: 1.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  471 LGQAYALLDMHLYS--LYYFQKACTLKPWDRRIWQVLGECYSKTGNKVEAIKCYKRSIKASQtvDQNTSIYYRLAQLYEE 548
Cdd:cd24142   4 LEKAEELLDQGNFElaLKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDP--DGGYEKYLYLGQLSGG 81


                ....*
gi 6321960  549 LEDLQ 553
Cdd:cd24142  82 EEALQ 86
PTH2 pfam01981
Peptidyl-tRNA hydrolase PTH2; Peptidyl-tRNA hydrolases are enzymes that release tRNAs from ...
 447-474 1.28e-03

Peptidyl-tRNA hydrolase PTH2; Peptidyl-tRNA hydrolases are enzymes that release tRNAs from peptidyl-tRNA during translation.


Pssm-ID: 460403  Cd Length: 115  Bit Score: 38.97  E-value: 1.28e-03
                          10        20
                  ....*....|....*....|....*...
gi 6321960    447 SHAAIECYRRAVDICPRDFKAWFGLGQA 474
Cdd:pfam01981  23 AHAAVAAYEKALKPNPELLREWEREGQK 50
Pth2 COG1990
Peptidyl-tRNA hydrolase [Translation, ribosomal structure and biogenesis];
448-474 1.41e-03

Peptidyl-tRNA hydrolase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441593  Cd Length: 117  Bit Score: 39.00  E-value: 1.41e-03
                        10        20
                ....*....|....*....|....*..
gi 6321960  448 HAAIECYRRAVDICPRDFKAWFGLGQA 474
Cdd:COG1990  26 HAAVSAALDALKKDKEWFEEWKDEGQK 52
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 448-600 2.03e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.17  E-value: 2.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  448 HAAIECYRRAVDICPRDFKAWFGLGQAYALLDMHLYSLYYFQKAC-TLKPWDRRIWQVLGECYSKTGNKVEAIKCYKRSI 526
Cdd:COG5010   2 RALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGrDKLAKAFAIESPSDNLYNKLGDFEESLALLEQAL 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6321960  527 KASqtvDQNTSIYYRLAQLYEELEDLQECKKFMMKCVDVEellegivtDETVKARLWLAIFEIKAGNYQLAYDY 600
Cdd:COG5010  82 QLD---PNNPELYYNLALLYSRSGDKDEAKEYYEKALALS--------PDNPNAYSNLAALLLSLGQDDEAKAA 144
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 436-496 2.13e-03

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 36.93  E-value: 2.13e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6321960    436 LMGHEFVELSNSHAAIECYRRAVD---ICPRDFKAWFGLGQAYALLDMHLYSLYYFQKACTLKP 496
Cdd:pfam13432   2 ALARAALRAGDYDDAAAALEAALArfpESPDAAAALLLLGLAALRQGRLAEAAAAYRAALRAAP 65
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 264-520 3.96e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.45  E-value: 3.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960    264 DALLLNNYLyQNFQFKFSENLGSQRTI----EFNIMIKFFKLKVFEELnGQLEDYFEDLEFLLQVFPNFTFLKAYNATIS 339
Cdd:TIGR02917 194 DALLLKGDL-LLSLGNIELALAAYRKAialrPNNIAVLLALATILIEA-GEFEEAEKHADALLKKAPNSPLAHYLKALVD 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960    340 YNNLDYVTAESRFDDIVKQDPYRLNDLEtysnilyvmqknskLAYLAQFvsqidrfrpetcciianyysARQEHEKSIMY 419
Cdd:TIGR02917 272 FQKKNYEDARETLQDALKSAPEYLPALL--------------LAGASEY--------------------QLGNLEQAYQY 317

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960    420 FRRALTLDKKTTNAWTLMGHEFVELSNSHAAIECYRRAVDICPRDFKAWFGLGQAYALLDMHLYSLYYFQKACTLKPWDR 499
Cdd:TIGR02917 318 LNQILKYAPNSHQARRLLASIQLRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENA 397

                         250       260
                  ....*....|....*....|.
gi 6321960    500 RIWQVLGECYSKTGNKVEAIK 520
Cdd:TIGR02917 398 AARTQLGISKLSQGDPSEAIA 418
TPR_8 pfam13181
Tetratricopeptide repeat;
537-567 5.02e-03

Tetratricopeptide repeat;


Pssm-ID: 404131 [Multi-domain]  Cd Length: 33  Bit Score: 35.07  E-value: 5.02e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 6321960    537 SIYYRLAQLYEELEDLQECKKFMMKCVDVEE 567
Cdd:pfam13181   2 EAYYNLGLIYLKLGDYEEAKEYYEKALELDP 32
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 487-529 5.21e-03

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 39.51  E-value: 5.21e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 6321960  487 YFQKACTLKPwDRRIWQVLGECYSKTGNKVEAIKCYKRSIKAS 529
Cdd:COG3071 280 YLEAALALRP-SAEAYAELARLLEQLGDPEEAAEHYRKALALA 321
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 306-427 7.71e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 37.09  E-value: 7.71e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6321960  306 ELNGQLEDYFEDLEFLLQVFPNFTFLKAYNATISYNNLDYVTAESRFDDIVKQDPyrlNDLETYSNILYVMQKNSK---- 381
Cdd:COG4783  15 LLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDP---DEPEARLNLGLALLKAGDydea 91

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 6321960  382 LAYLAQFVsQIDRFRPETCCIIANYYSARQEHEKSIMYFRRALTLD 427
Cdd:COG4783  92 LALLEKAL-KLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
PTH2 cd02430
Peptidyl-tRNA hydrolase, type 2 (PTH2). Peptidyl-tRNA hydrolase (PTH) activity releases tRNA ...
 447-474 9.50e-03

Peptidyl-tRNA hydrolase, type 2 (PTH2). Peptidyl-tRNA hydrolase (PTH) activity releases tRNA from the premature translation termination product peptidyl-tRNA, therefore allowing the tRNA and peptide to be reused in protein synthesis. PTH2 is present in archaea and eukaryotes.


Pssm-ID: 239108  Cd Length: 115  Bit Score: 36.35  E-value: 9.50e-03
                        10        20
                ....*....|....*....|....*...
gi 6321960  447 SHAAIECYRRAVDICPRDFKAWFGLGQA 474
Cdd:cd02430  23 AHAALGAYKKAMKSNPELLRAWEREGQK 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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