NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|6322312|ref|NP_012386|]
View 

SCF ubiquitin ligase complex subunit DAS1 [Saccharomyces cerevisiae S288C]

Protein Classification

F-box protein( domain architecture ID 17778692)

F-box protein functions as the substrate-recognition component of an SCF (Skp1-Cullin-F-box protein) ubiquitin-protein ligase that is involved in ubiquitin-dependent degradation

CATH:  1.20.1280.50
Gene Ontology:  GO:0019005|GO:0005515|GO:0006511
PubMed:  31898225|11178263
SCOP:  4001927

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
F-box_ScMDM30-like cd22143
F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology ...
 48-91 1.83e-12

F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology protein 30 (ScMDM30) and similar proteins; ScMDM30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. It is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ScMDM30 recognizes FZO1 and regulates the amount of FZO1. It acts as a regulatory factor for the mitochondrial fusion machinery and is required for mitochondrial DNA maintenance. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438915  Cd Length: 44  Bit Score: 61.86  E-value: 1.83e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 6322312   48 PLTKLPDELMQEVFSHLPQPDRLQLCLVNKRLNKIATKLLYRRI 91
Cdd:cd22143   1 AFDSLPDEILSIIFSHLPQSDLYNLLFVNKHFYSLALPELWRSI 44
 
Name Accession Description Interval E-value
F-box_ScMDM30-like cd22143
F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology ...
 48-91 1.83e-12

F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology protein 30 (ScMDM30) and similar proteins; ScMDM30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. It is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ScMDM30 recognizes FZO1 and regulates the amount of FZO1. It acts as a regulatory factor for the mitochondrial fusion machinery and is required for mitochondrial DNA maintenance. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438915  Cd Length: 44  Bit Score: 61.86  E-value: 1.83e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 6322312   48 PLTKLPDELMQEVFSHLPQPDRLQLCLVNKRLNKIATKLLYRRI 91
Cdd:cd22143   1 AFDSLPDEILSIIFSHLPQSDLYNLLFVNKHFYSLALPELWRSI 44
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 49-92 8.81e-08

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 48.63  E-value: 8.81e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 6322312     49 LTKLPDELMQEVFSHLPQPDRLQLCLVNKRLNKIATK-LLYRRIY 92
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDdSLWRRLC 45
FBOX smart00256
A Receptor for Ubiquitination Targets;
52-82 5.24e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 40.88  E-value: 5.24e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 6322312      52 LPDELMQEVFSHLPQPDRLQLCLVNKRLNKI 82
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSL 31
 
Name Accession Description Interval E-value
F-box_ScMDM30-like cd22143
F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology ...
 48-91 1.83e-12

F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology protein 30 (ScMDM30) and similar proteins; ScMDM30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast. It is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ScMDM30 recognizes FZO1 and regulates the amount of FZO1. It acts as a regulatory factor for the mitochondrial fusion machinery and is required for mitochondrial DNA maintenance. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438915  Cd Length: 44  Bit Score: 61.86  E-value: 1.83e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 6322312   48 PLTKLPDELMQEVFSHLPQPDRLQLCLVNKRLNKIATKLLYRRI 91
Cdd:cd22143   1 AFDSLPDEILSIIFSHLPQSDLYNLLFVNKHFYSLALPELWRSI 44
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 49-92 8.81e-08

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 48.63  E-value: 8.81e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 6322312     49 LTKLPDELMQEVFSHLPQPDRLQLCLVNKRLNKIATK-LLYRRIY 92
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDdSLWRRLC 45
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 50-84 7.10e-07

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 45.90  E-value: 7.10e-07
                        10        20        30
                ....*....|....*....|....*....|....*
gi 6322312   50 TKLPDELMQEVFSHLPQPDRLQLCLVNKRLNKIAT 84
Cdd:cd09917   1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
FBOX smart00256
A Receptor for Ubiquitination Targets;
52-82 5.24e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 40.88  E-value: 5.24e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 6322312      52 LPDELMQEVFSHLPQPDRLQLCLVNKRLNKI 82
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSL 31
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 49-86 1.58e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 39.45  E-value: 1.58e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 6322312     49 LTKLPDELMQEVFSHLPQPDRLQLCLVNKRLNKIATKL 86
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSL 38
F-box_FBXL4 cd22117
F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also ...
 49-94 2.00e-03

F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438889  Cd Length: 47  Bit Score: 36.45  E-value: 2.00e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 6322312   49 LTKLPDELMQEVFSHLPQPDRLQLCLVNKRLNKIATK-LLYRRIYLN 94
Cdd:cd22117   1 FDLLPYELIQLILSYLDLPSLCRLSQTCKLFRKHCYDpLLWKELNLQ 47
F-box_FBXO31 cd22102
F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called ...
 49-90 6.40e-03

F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called FBX31, or FBXO14, is a component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. It specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. FBXO31 may act as a tumor suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438874  Cd Length: 48  Bit Score: 35.10  E-value: 6.40e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 6322312   49 LTKLPDELMQEVFSHLPQPDRLQLCLVNKRLNKI-ATKLLYRR 90
Cdd:cd22102   1 ILDLPPELLVEIFSSLPGTDLPSLAQVCKKFREIlNTDTIWQR 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH