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Conserved domains on  [gi|6322349|ref|NP_012423|]
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Mdv1p [Saccharomyces cerevisiae S288C]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 397-713 8.45e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.38  E-value: 8.45e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  397 HDDFLTCLDFDAPFGTLCTAGYlDHTVKIWDLSKQNKIGELAGHLATINCMQINRDYGTLVTGGRDAALKLWNLNlaqql 476
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSG-DGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE----- 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  477 yqetqnltsptnhiDSPCVHTFEAHTDEVTALSLDPS--FLVSGSQDRTIRQWDLRSGKCLQTIDLSFANVlttsTNVDL 554
Cdd:cd00200  82 --------------TGECVRTLTGHTSYVSSVAFSPDgrILSSSSRDKTIKVWDVETGKCLTTLRGHTDWV----NSVAF 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  555 SKSTLLtqrnerpsigalqsfdaaLATGTKDGVVRLWDLRSGKVIRTLKGHTDAITSLKF--DSACLVTGSYDRTVRIWD 632
Cdd:cd00200 144 SPDGTF------------------VASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFspDGEKLLSSSSDGTIKLWD 205

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  633 LRTG-LLNKFHAYSAPVLSLDLFQENAAVVVADE-PSVQIYDSEKDESWSCVeQGNETSVSTVKY--KENYMVEGRENGD 708
Cdd:cd00200 206 LSTGkCLGTLRGHENGVNSVAFSPDGYLLASGSEdGTIRVWDLRTGECVQTL-SGHTNSVTSLAWspDGKRLASGSADGT 284


                ....*
gi 6322349  709 VNIWA 713
Cdd:cd00200 285 IRIWD 289
Mdv1 pfam11542
Mitochondrial division protein 1; Mdv1 is a component of the mitochondrial fission machinery ...
 123-171 1.60e-28

Mitochondrial division protein 1; Mdv1 is a component of the mitochondrial fission machinery in Saccharomyces cerevisiae. The protein is also involved in peroxisome proliferation. Mdv1 along with Fis1 is also involved in controlling Dnm-1 dependant devision, a GTPase involved in the mediation of mitochondrial division. In this role, Mdv1 is the linker between Fis1 and Dnm1. Mdv1 plays a key role in the regulation of Dnm1 self-assembly.


:

Pssm-ID: 402923  Cd Length: 49  Bit Score: 107.93  E-value: 1.60e-28
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 6322349    123 ADGKLLTEGGENENLRKNASKKETSLFQGFKSYLPIAELAIENTERLNY 171
Cdd:pfam11542   1 ADGKLLTEGGENENLRKNASKKETSLFQGFKSYLPIAELAIENTERLNY 49
Mdv1_N cd22881
N-terminal extended coiled-coil domain of Saccharomyces cerevisiae mitochondrial division ...
 97-298 1.58e-22

N-terminal extended coiled-coil domain of Saccharomyces cerevisiae mitochondrial division protein 1 (Mdv1) and similar proteins; Mdv1, also known as mitochondrial fission 2 protein (FIS2), GAG3, or NET2, is involved in the mitochondrial fission machinery of the yeast Saccharomyces cerevisiae. Together with Fis1 and Dnm1, Mdv1 is an essential component of the machinery that mediates mitochondrial fission, a process crucial for mitochondrial maintenance and function. Mdv1 is an adapter protein that binds Fis1 and Dnm1 to form mitochondrial fission complexes, which facilitate the constriction and fission of the mitochondrial compartment during the late stages of mitochondrial division. Mdv1 works together with Caf4 to recruit Dnm1 to Fis1 on the mitochondrial outer membrane. Mdv1 protein has three domains: N-terminal extension, central coiled coil (CC), and C-terminal WD40 repeat region. The N-terminal extension binds to Fis1, while the CC domain facilitates dimerization of Mdv1 and is responsible for the recruitment of Dnm1 to the mitochondrial membrane. Both are included in this model. The C-terminal WD40 repeat region binds to Dnm1.


:

Pssm-ID: 467856  Cd Length: 108  Bit Score: 92.96  E-value: 1.58e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349   97 TCFRMLTYISDDLLNEIPTkeglksdadgkllteggenenlrkNASKKETSLFQGFKSYLPIaelaienterlnydtngt 176
Cdd:cd22881   1 ITFRALTYLPDELLNDIPE------------------------DGEDSSYSLFQGFQATLPE------------------ 38

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  177 sgtvgakdvmsktnerdeihtelpnfqdsflippgvetkkisssyspsalksFSQTLVNSLEFLNIQKNSTLSEIRDIEV 256
Cdd:cd22881  39 ----------------------------------------------------EKEDINHKLDLLEIRKNLAASEIREIDN 66

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 6322349  257 EVENLRQKKEKLLGKIANIEQNQLLLEDNLKQIDDRLDFLEE 298
Cdd:cd22881  67 KIANLNSMRKIVFERIAKLEKEELELENELEEIKDRIEFIKE 108
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 397-713 8.45e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.38  E-value: 8.45e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  397 HDDFLTCLDFDAPFGTLCTAGYlDHTVKIWDLSKQNKIGELAGHLATINCMQINRDYGTLVTGGRDAALKLWNLNlaqql 476
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSG-DGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE----- 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  477 yqetqnltsptnhiDSPCVHTFEAHTDEVTALSLDPS--FLVSGSQDRTIRQWDLRSGKCLQTIDLSFANVlttsTNVDL 554
Cdd:cd00200  82 --------------TGECVRTLTGHTSYVSSVAFSPDgrILSSSSRDKTIKVWDVETGKCLTTLRGHTDWV----NSVAF 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  555 SKSTLLtqrnerpsigalqsfdaaLATGTKDGVVRLWDLRSGKVIRTLKGHTDAITSLKF--DSACLVTGSYDRTVRIWD 632
Cdd:cd00200 144 SPDGTF------------------VASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFspDGEKLLSSSSDGTIKLWD 205

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  633 LRTG-LLNKFHAYSAPVLSLDLFQENAAVVVADE-PSVQIYDSEKDESWSCVeQGNETSVSTVKY--KENYMVEGRENGD 708
Cdd:cd00200 206 LSTGkCLGTLRGHENGVNSVAFSPDGYLLASGSEdGTIRVWDLRTGECVQTL-SGHTNSVTSLAWspDGKRLASGSADGT 284


                ....*
gi 6322349  709 VNIWA 713
Cdd:cd00200 285 IRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
397-651 7.82e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 171.25  E-value: 7.82e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  397 HDDFLTCLDFdAPFGTLCTAGYLDHTVKIWDLSKQNKIGELAGHLATINCMQINRDYGTLVTGGRDAALKLWNLNlaqql 476
Cdd:COG2319 119 HTGAVRSVAF-SPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA----- 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  477 yqetqnltsptnhiDSPCVHTFEAHTDEVTALSLDP--SFLVSGSQDRTIRQWDLRSGKCLQTIDLSFANVLTtstnVDL 554
Cdd:COG2319 193 --------------TGKLLRTLTGHTGAVRSVAFSPdgKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRS----VAF 254

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  555 SKStlltqrnerpsiGALqsfdaaLATGTKDGVVRLWDLRSGKVIRTLKGHTDAITSLKF--DSACLVTGSYDRTVRIWD 632
Cdd:COG2319 255 SPD------------GRL------LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLLASGSDDGTVRLWD 316

                       250       260
                ....*....|....*....|
gi 6322349  633 LRTG-LLNKFHAYSAPVLSL 651
Cdd:COG2319 317 LATGkLLRTLTGHTGAVRSV 336
Mdv1 pfam11542
Mitochondrial division protein 1; Mdv1 is a component of the mitochondrial fission machinery ...
 123-171 1.60e-28

Mitochondrial division protein 1; Mdv1 is a component of the mitochondrial fission machinery in Saccharomyces cerevisiae. The protein is also involved in peroxisome proliferation. Mdv1 along with Fis1 is also involved in controlling Dnm-1 dependant devision, a GTPase involved in the mediation of mitochondrial division. In this role, Mdv1 is the linker between Fis1 and Dnm1. Mdv1 plays a key role in the regulation of Dnm1 self-assembly.


Pssm-ID: 402923  Cd Length: 49  Bit Score: 107.93  E-value: 1.60e-28
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 6322349    123 ADGKLLTEGGENENLRKNASKKETSLFQGFKSYLPIAELAIENTERLNY 171
Cdd:pfam11542   1 ADGKLLTEGGENENLRKNASKKETSLFQGFKSYLPIAELAIENTERLNY 49
Mdv1_N cd22881
N-terminal extended coiled-coil domain of Saccharomyces cerevisiae mitochondrial division ...
 97-298 1.58e-22

N-terminal extended coiled-coil domain of Saccharomyces cerevisiae mitochondrial division protein 1 (Mdv1) and similar proteins; Mdv1, also known as mitochondrial fission 2 protein (FIS2), GAG3, or NET2, is involved in the mitochondrial fission machinery of the yeast Saccharomyces cerevisiae. Together with Fis1 and Dnm1, Mdv1 is an essential component of the machinery that mediates mitochondrial fission, a process crucial for mitochondrial maintenance and function. Mdv1 is an adapter protein that binds Fis1 and Dnm1 to form mitochondrial fission complexes, which facilitate the constriction and fission of the mitochondrial compartment during the late stages of mitochondrial division. Mdv1 works together with Caf4 to recruit Dnm1 to Fis1 on the mitochondrial outer membrane. Mdv1 protein has three domains: N-terminal extension, central coiled coil (CC), and C-terminal WD40 repeat region. The N-terminal extension binds to Fis1, while the CC domain facilitates dimerization of Mdv1 and is responsible for the recruitment of Dnm1 to the mitochondrial membrane. Both are included in this model. The C-terminal WD40 repeat region binds to Dnm1.


Pssm-ID: 467856  Cd Length: 108  Bit Score: 92.96  E-value: 1.58e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349   97 TCFRMLTYISDDLLNEIPTkeglksdadgkllteggenenlrkNASKKETSLFQGFKSYLPIaelaienterlnydtngt 176
Cdd:cd22881   1 ITFRALTYLPDELLNDIPE------------------------DGEDSSYSLFQGFQATLPE------------------ 38

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  177 sgtvgakdvmsktnerdeihtelpnfqdsflippgvetkkisssyspsalksFSQTLVNSLEFLNIQKNSTLSEIRDIEV 256
Cdd:cd22881  39 ----------------------------------------------------EKEDINHKLDLLEIRKNLAASEIREIDN 66

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 6322349  257 EVENLRQKKEKLLGKIANIEQNQLLLEDNLKQIDDRLDFLEE 298
Cdd:cd22881  67 KIANLNSMRKIVFERIAKLEKEELELENELEEIKDRIEFIKE 108
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 595-632 2.50e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.78  E-value: 2.50e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 6322349     595 SGKVIRTLKGHTDAITSLKF--DSACLVTGSYDRTVRIWD 632
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 509-633 8.73e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 62.03  E-value: 8.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349   509 SLDPSFLVSGSQDRTIRQWDLRSGKCLQTIDLSfANVLTTSTNVDLSKStlltqrnerpsigalqsfdaaLATGTKDGVV 588
Cdd:PLN00181 585 SADPTLLASGSDDGSVKLWSINQGVSIGTIKTK-ANICCVQFPSESGRS---------------------LAFGSADHKV 642

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 6322349   589 RLWDLRSGKV-IRTLKGHTDAITSLKF-DSACLVTGSYDRTVRIWDL 633
Cdd:PLN00181 643 YYYDLRNPKLpLCTMIGHSKTVSYVRFvDSSTLVSSSTDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
596-632 1.48e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.89  E-value: 1.48e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 6322349    596 GKVIRTLKGHTDAITSLKF--DSACLVTGSYDRTVRIWD 632
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
235-355 2.62e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 40.66  E-value: 2.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  235 NSLEFLNIQKNSTLSEIRDIEVEVENLRQKKEKLLGKIANIEQNQLLLEDNLKQIDDRLDFLEEyGLEVIEANSDENAED 314
Cdd:COG4372 101 EELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQE-ELAALEQELQALSEA 179

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 6322349  315 DGMSERKALKNDAIRNEGVTTESISSEASNLPPRRRQQLRD 355
Cdd:COG4372 180 EAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEEL 220
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 397-713 8.45e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.38  E-value: 8.45e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  397 HDDFLTCLDFDAPFGTLCTAGYlDHTVKIWDLSKQNKIGELAGHLATINCMQINRDYGTLVTGGRDAALKLWNLNlaqql 476
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSG-DGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE----- 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  477 yqetqnltsptnhiDSPCVHTFEAHTDEVTALSLDPS--FLVSGSQDRTIRQWDLRSGKCLQTIDLSFANVlttsTNVDL 554
Cdd:cd00200  82 --------------TGECVRTLTGHTSYVSSVAFSPDgrILSSSSRDKTIKVWDVETGKCLTTLRGHTDWV----NSVAF 143

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  555 SKSTLLtqrnerpsigalqsfdaaLATGTKDGVVRLWDLRSGKVIRTLKGHTDAITSLKF--DSACLVTGSYDRTVRIWD 632
Cdd:cd00200 144 SPDGTF------------------VASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFspDGEKLLSSSSDGTIKLWD 205

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  633 LRTG-LLNKFHAYSAPVLSLDLFQENAAVVVADE-PSVQIYDSEKDESWSCVeQGNETSVSTVKY--KENYMVEGRENGD 708
Cdd:cd00200 206 LSTGkCLGTLRGHENGVNSVAFSPDGYLLASGSEdGTIRVWDLRTGECVQTL-SGHTNSVTSLAWspDGKRLASGSADGT 284


                ....*
gi 6322349  709 VNIWA 713
Cdd:cd00200 285 IRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
397-651 7.82e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 171.25  E-value: 7.82e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  397 HDDFLTCLDFdAPFGTLCTAGYLDHTVKIWDLSKQNKIGELAGHLATINCMQINRDYGTLVTGGRDAALKLWNLNlaqql 476
Cdd:COG2319 119 HTGAVRSVAF-SPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA----- 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  477 yqetqnltsptnhiDSPCVHTFEAHTDEVTALSLDP--SFLVSGSQDRTIRQWDLRSGKCLQTIDLSFANVLTtstnVDL 554
Cdd:COG2319 193 --------------TGKLLRTLTGHTGAVRSVAFSPdgKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRS----VAF 254

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  555 SKStlltqrnerpsiGALqsfdaaLATGTKDGVVRLWDLRSGKVIRTLKGHTDAITSLKF--DSACLVTGSYDRTVRIWD 632
Cdd:COG2319 255 SPD------------GRL------LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLLASGSDDGTVRLWD 316

                       250       260
                ....*....|....*....|
gi 6322349  633 LRTG-LLNKFHAYSAPVLSL 651
Cdd:COG2319 317 LATGkLLRTLTGHTGAVRSV 336
WD40 COG2319
WD40 repeat [General function prediction only];
397-635 7.13e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.85  E-value: 7.13e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  397 HDDFLTCLDFdAPFGTLCTAGYLDHTVKIWDLSKQNKIGELAGHLATINCMQINRDYGTLVTGGRDAALKLWNLNlaqql 476
Cdd:COG2319 203 HTGAVRSVAF-SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA----- 276

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  477 yqetqnltsptnhiDSPCVHTFEAHTDEVTAL--SLDPSFLVSGSQDRTIRQWDLRSGKCLQTIDLSFANVLTtstnVDL 554
Cdd:COG2319 277 --------------TGELLRTLTGHSGGVNSVafSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS----VAF 338

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  555 SkstlltqrnerpsigalqSFDAALATGTKDGVVRLWDLRSGKVIRTLKGHTDAITSLKF--DSACLVTGSYDRTVRIWD 632
Cdd:COG2319 339 S------------------PDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFspDGRTLASGSADGTVRLWD 400


                ...
gi 6322349  633 LRT 635
Cdd:COG2319 401 LAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
406-714 1.88e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.14  E-value: 1.88e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  406 FDAPFGTLCTAGYLDHTVKIWDLSKQNKIGELAGHLATINCMQINRDYGTLVTGGRDAALKLWNLNlaqqlyqetqnlts 485
Cdd:COG2319  43 AASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA-------------- 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  486 ptnhiDSPCVHTFEAHTDEVTALSLDP--SFLVSGSQDRTIRQWDLRSGKCLQTIDLSFANVlttsTNVDLSKStlltqr 563
Cdd:COG2319 109 -----TGLLLRTLTGHTGAVRSVAFSPdgKTLASGSADGTVRLWDLATGKLLRTLTGHSGAV----TSVAFSPD------ 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  564 nerpsiGALqsfdaaLATGTKDGVVRLWDLRSGKVIRTLKGHTDAITSLKF--DSACLVTGSYDRTVRIWDLRTG-LLNK 640
Cdd:COG2319 174 ------GKL------LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRLWDLATGkLLRT 241

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6322349  641 FHAYSAPVLSLDLFQENAAVVVADE-PSVQIYDSEKDESWScVEQGNETSVSTVKY--KENYMVEGRENGDVNIWAV 714
Cdd:COG2319 242 LTGHSGSVRSVAFSPDGRLLASGSAdGTVRLWDLATGELLR-TLTGHSGGVNSVAFspDGKLLASGSDDGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 494-712 2.99e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.90  E-value: 2.99e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  494 CVHTFEAHTDEVTALSLDP--SFLVSGSQDRTIRQWDLRSGKCLQT-----------IDLSFAN-VLTTSTN-----VDL 554
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTlkghtgpvrdvAASADGTyLASGSSDktirlWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  555 SKSTLL-TQRNERPSIGALqSFDAA---LATGTKDGVVRLWDLRSGKVIRTLKGHTDAITSLKF--DSACLVTGSYDRTV 628
Cdd:cd00200  81 ETGECVrTLTGHTSYVSSV-AFSPDgriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspDGTFVASSSQDGTI 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  629 RIWDLRTGLLNK-FHAYSAPVLSLDLFQENAAVVVA-DEPSVQIYDSeKDESWSCVEQGNETSVSTVKYKEN--YMVEGR 704
Cdd:cd00200 160 KLWDLRTGKCVAtLTGHTGEVNSVAFSPDGEKLLSSsSDGTIKLWDL-STGKCLGTLRGHENGVNSVAFSPDgyLLASGS 238


                ....*...
gi 6322349  705 ENGDVNIW 712
Cdd:cd00200 239 EDGTIRVW 246
Mdv1 pfam11542
Mitochondrial division protein 1; Mdv1 is a component of the mitochondrial fission machinery ...
 123-171 1.60e-28

Mitochondrial division protein 1; Mdv1 is a component of the mitochondrial fission machinery in Saccharomyces cerevisiae. The protein is also involved in peroxisome proliferation. Mdv1 along with Fis1 is also involved in controlling Dnm-1 dependant devision, a GTPase involved in the mediation of mitochondrial division. In this role, Mdv1 is the linker between Fis1 and Dnm1. Mdv1 plays a key role in the regulation of Dnm1 self-assembly.


Pssm-ID: 402923  Cd Length: 49  Bit Score: 107.93  E-value: 1.60e-28
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 6322349    123 ADGKLLTEGGENENLRKNASKKETSLFQGFKSYLPIAELAIENTERLNY 171
Cdd:pfam11542   1 ADGKLLTEGGENENLRKNASKKETSLFQGFKSYLPIAELAIENTERLNY 49
WD40 COG2319
WD40 repeat [General function prediction only];
408-651 5.09e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.93  E-value: 5.09e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  408 APFGTLCTAGYLDHTVKIWDLSKQNKIGELAGHLATINCMQINRDYGTLVTGGRDAALKLWNLnlaqqlyqetqnltspt 487
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDA----------------- 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  488 nhIDSPCVHTFEAHTDEVT--ALSLDPSFLVSGSQDRTIRQWDLRSGKCLQTIDLSFANVlttsTNVDLSkstlltqrne 565
Cdd:COG2319  66 --AAGALLATLLGHTAAVLsvAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAV----RSVAFS---------- 129

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  566 rPSiGALqsfdaaLATGTKDGVVRLWDLRSGKVIRTLKGHTDAITSLKF--DSACLVTGSYDRTVRIWDLRTG-LLNKFH 642
Cdd:COG2319 130 -PD-GKT------LASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFspDGKLLASGSDDGTVRLWDLATGkLLRTLT 201


                ....*....
gi 6322349  643 AYSAPVLSL 651
Cdd:COG2319 202 GHTGAVRSV 210
Mdv1_N cd22881
N-terminal extended coiled-coil domain of Saccharomyces cerevisiae mitochondrial division ...
 97-298 1.58e-22

N-terminal extended coiled-coil domain of Saccharomyces cerevisiae mitochondrial division protein 1 (Mdv1) and similar proteins; Mdv1, also known as mitochondrial fission 2 protein (FIS2), GAG3, or NET2, is involved in the mitochondrial fission machinery of the yeast Saccharomyces cerevisiae. Together with Fis1 and Dnm1, Mdv1 is an essential component of the machinery that mediates mitochondrial fission, a process crucial for mitochondrial maintenance and function. Mdv1 is an adapter protein that binds Fis1 and Dnm1 to form mitochondrial fission complexes, which facilitate the constriction and fission of the mitochondrial compartment during the late stages of mitochondrial division. Mdv1 works together with Caf4 to recruit Dnm1 to Fis1 on the mitochondrial outer membrane. Mdv1 protein has three domains: N-terminal extension, central coiled coil (CC), and C-terminal WD40 repeat region. The N-terminal extension binds to Fis1, while the CC domain facilitates dimerization of Mdv1 and is responsible for the recruitment of Dnm1 to the mitochondrial membrane. Both are included in this model. The C-terminal WD40 repeat region binds to Dnm1.


Pssm-ID: 467856  Cd Length: 108  Bit Score: 92.96  E-value: 1.58e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349   97 TCFRMLTYISDDLLNEIPTkeglksdadgkllteggenenlrkNASKKETSLFQGFKSYLPIaelaienterlnydtngt 176
Cdd:cd22881   1 ITFRALTYLPDELLNDIPE------------------------DGEDSSYSLFQGFQATLPE------------------ 38

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  177 sgtvgakdvmsktnerdeihtelpnfqdsflippgvetkkisssyspsalksFSQTLVNSLEFLNIQKNSTLSEIRDIEV 256
Cdd:cd22881  39 ----------------------------------------------------EKEDINHKLDLLEIRKNLAASEIREIDN 66

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 6322349  257 EVENLRQKKEKLLGKIANIEQNQLLLEDNLKQIDDRLDFLEE 298
Cdd:cd22881  67 KIANLNSMRKIVFERIAKLEKEELELENELEEIKDRIEFIKE 108
WD40 COG2319
WD40 repeat [General function prediction only];
382-531 3.11e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.82  E-value: 3.11e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  382 QLYEPGT-KIGSIMSTHDDFLTCLDFdAPFGTLCTAGYLDHTVKIWDLSKQNKIGELAGHLATINCMQINRDYGTLVTGG 460
Cdd:COG2319 229 RLWDLATgKLLRTLTGHSGSVRSVAF-SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGS 307

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  461 RDAALKLWNLNLAQQLyqetQNLTSPTNHIDS---------------------------PCVHTFEAHTDEVTALSLDP- 512
Cdd:COG2319 308 DDGTVRLWDLATGKLL----RTLTGHTGAVRSvafspdgktlasgsddgtvrlwdlatgELLRTLTGHTGAVTSVAFSPd 383

                       170       180
                ....*....|....*....|
gi 6322349  513 -SFLVSGSQDRTIRQWDLRS 531
Cdd:COG2319 384 gRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 595-632 2.50e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.78  E-value: 2.50e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 6322349     595 SGKVIRTLKGHTDAITSLKF--DSACLVTGSYDRTVRIWD 632
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 509-633 8.73e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 62.03  E-value: 8.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349   509 SLDPSFLVSGSQDRTIRQWDLRSGKCLQTIDLSfANVLTTSTNVDLSKStlltqrnerpsigalqsfdaaLATGTKDGVV 588
Cdd:PLN00181 585 SADPTLLASGSDDGSVKLWSINQGVSIGTIKTK-ANICCVQFPSESGRS---------------------LAFGSADHKV 642

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 6322349   589 RLWDLRSGKV-IRTLKGHTDAITSLKF-DSACLVTGSYDRTVRIWDL 633
Cdd:PLN00181 643 YYYDLRNPKLpLCTMIGHSKTVSYVRFvDSSTLVSSSTDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
596-632 1.48e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.89  E-value: 1.48e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 6322349    596 GKVIRTLKGHTDAITSLKF--DSACLVTGSYDRTVRIWD 632
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
507-672 2.18e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.84  E-value: 2.18e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  507 ALSLDPSFLVSGSQDRTIRQWDLRSGKCLQTidlsfanvlttstnvdlskstlLTQRNERPSIGALQSFDAALATGTKDG 586
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLL----------------------LLGLAAAVASLAASPDGARLAAGAGDL 58

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  587 VVRLWDLRSGKVIRTLKGHTDAITSLKF--DSACLVTGSYDRTVRIWDLRTG-LLNKFHAYSAPVLSLDLFQENAAVVVA 663
Cdd:COG2319  59 TLLLLDAAAGALLATLLGHTAAVLSVAFspDGRLLASASADGTVRLWDLATGlLLRTLTGHTGAVRSVAFSPDGKTLASG 138

                       170
                ....*....|
gi 6322349  664 DEP-SVQIYD 672
Cdd:COG2319 139 SADgTVRLWD 148
WD40 pfam00400
WD domain, G-beta repeat;
494-528 4.12e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.65  E-value: 4.12e-08
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 6322349    494 CVHTFEAHTDEVTALSLDP--SFLVSGSQDRTIRQWD 528
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPdgKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 494-528 5.83e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.23  E-value: 5.83e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 6322349     494 CVHTFEAHTDEVTALSLDP--SFLVSGSQDRTIRQWD 528
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPdgKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 511-636 4.69e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.97  E-value: 4.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349   511 DPSFLVSGSQDRTIRQWDLRsgkclqtidlsfANVLTTSTNvdlskSTLLTQRNERPSIGALQ---SFDAALATGTKDGV 587
Cdd:PTZ00421  87 DPQKLFTASEDGTIMGWGIP------------EEGLTQNIS-----DPIVHLQGHTKKVGIVSfhpSAMNVLASAGADMV 149

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 6322349   588 VRLWDLRSGKVIRTLKGHTDAITSLKF--DSACLVTGSYDRTVRIWDLRTG 636
Cdd:PTZ00421 150 VNVWDVERGKAVEVIKCHSDQITSLEWnlDGSLLCTTSKDKKLNIIDPRDG 200
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 387-520 2.87e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.39  E-value: 2.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349   387 GTKIGSIMSTHDdfLTCLDFDAPFGTLCTAGYLDHTVKIWDLSKQN-KIGELAGHLATINCMQInRDYGTLVTGGRDAAL 465
Cdd:PLN00181 608 GVSIGTIKTKAN--ICCVQFPSESGRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTL 684

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 6322349   466 KLWNLNLAQQLYQETQnltsptnhidspcVHTFEAHTD--EVTALSLDPSFLVSGSQ 520
Cdd:PLN00181 685 KLWDLSMSISGINETP-------------LHSFMGHTNvkNFVGLSVSDGYIATGSE 728
PTZ00421 PTZ00421
coronin; Provisional
 456-703 4.38e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.81  E-value: 4.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349   456 LVTGGRDAALKLWNLnlaqqlyqETQNLTSptnHIDSPCVHtFEAHTDEVTALSLDPS---FLVSGSQDRTIRQWDLRSG 532
Cdd:PTZ00421  91 LFTASEDGTIMGWGI--------PEEGLTQ---NISDPIVH-LQGHTKKVGIVSFHPSamnVLASAGADMVVNVWDVERG 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349   533 KCLQTIDLSFANVLTTSTNVDlskstlltqrnerpsiGALqsfdaaLATGTKDGVVRLWDLRSGKVIRTLKGHT------ 606
Cdd:PTZ00421 159 KAVEVIKCHSDQITSLEWNLD----------------GSL------LCTTSKDKKLNIIDPRDGTIVSSVEAHAsaksqr 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349   607 -------DAITSLKFDSaclvtgSYDRTVRIWDLRTgllnkfhaYSAPVLSLDLFQENAAVV-VADEPSVQIYDSEKDES 678
Cdd:PTZ00421 217 clwakrkDLIITLGCSK------SQQRQIMLWDTRK--------MASPYSTVDLDQSSALFIpFFDEDTNLLYIGSKGEG 282

                        250       260
                 ....*....|....*....|....*.
gi 6322349   679 -WSCVEQGNETSVSTVKYKENYMVEG 703
Cdd:PTZ00421 283 nIRCFELMNERLTFCSSYSSVEPHKG 308
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 430-469 3.45e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 3.45e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 6322349     430 KQNKIGELAGHLATINCMQINRDYGTLVTGGRDAALKLWN 469
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 560-712 5.48e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.54  E-value: 5.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349   560 LTQRNERPSIGALQSFDAALATGTKDGVVRLWDLRSGKVIRTLKGHTDAITSLKFDSA---CLVTGSYDRTVRIWDLRTG 636
Cdd:PLN00181 529 LASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSAdptLLASGSDDGSVKLWSINQG 608

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349   637 LLNKFHAYSAPVLSLDLFQENA---AVVVADEpSVQIYDSEKDESWSCVEQGNETSVSTVKYKE-NYMVEGRENGDVNIW 712
Cdd:PLN00181 609 VSIGTIKTKANICCVQFPSESGrslAFGSADH-KVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDsSTLVSSSTDNTLKLW 687
WD40 pfam00400
WD domain, G-beta repeat;
393-427 7.11e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 7.11e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 6322349    393 IMSTHDDFLTCLDFDaPFGTLCTAGYLDHTVKIWD 427
Cdd:pfam00400   6 TLEGHTGSVTSLAFS-PDGKLLASGSDDGTVKVWD 39
Nup160 pfam11715
Nucleoporin Nup120/160; Nup120 is conserved from fungi to plants to humans, and is homologous ...
 440-581 8.34e-04

Nucleoporin Nup120/160; Nup120 is conserved from fungi to plants to humans, and is homologous with the Nup160 of vertebrates. The nuclear core complex, or NPC, mediates macromolecular transport across the nuclear envelope. Deletion of the NUP120 gene causes clustering of NPCs at one side of the nuclear envelope, moderate nucleolar fragmentation and slower cell growth. The vertebrate NPC is estimated to contain between 30 and 60 different proteins. most of which are not known. Two important ones in creating the nucleoporin basket are Nup98 and Nup153, and Nup120, in conjunction with Nup 133, interacts with these two and itself plays a role in mRNA export. Nup160, Nup133, Nup96, and Nup107 are all targets of phosphorylation. The phosphorylation sites are clustered mainly at the N-terminal regions of these proteins, which are predicted to be natively disordered. The entire Nup107-160 sub-complex is stable throughout the cell cycle, thus it seems unlikely that phosphorylation affects interactions within the Nup107-160 sub-complex, but rather that it regulates the association of the sub-complex with the NPC and other proteins.


Pssm-ID: 432020 [Multi-domain]  Cd Length: 540  Bit Score: 42.45  E-value: 8.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349    440 HLATINCMQINRDYGTLVTGGRDAA---------LKL-WNLNLAQ---QLYQETQNLTS----------PTNHIDSPCVH 496
Cdd:pfam11715 140 KSYVPSSFSGFSKPGRLVAVSPLELlvsladgglLKLtRSSDGGAwkeSTFEPASWLQSlsgllgwladPTIRYSGSSVA 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349    497 tFEAHTDEVTALSLDPSFLVSGSQDRTIRQWDLRSGKCLQTIDLSfanvLTTSTNVDLSKSTLLTQRNERpsIGALQSFD 576
Cdd:pfam11715 220 -LSLSAAPAVTTVGGQNFLFTLSLDHTLRVWDLLTGKCLATIDLL----DLELPQDSSSWLTLDPAPSSL--IRVSGSFR 292


                  ....*
gi 6322349    577 AALAT 581
Cdd:pfam11715 293 AYLVL 297
WD40 pfam00400
WD domain, G-beta repeat;
432-469 1.03e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.03e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 6322349    432 NKIGELAGHLATINCMQINRDYGTLVTGGRDAALKLWN 469
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 586-634 1.06e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.24  E-value: 1.06e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 6322349   586 GVVRLWD-LRSGKVIRtLKGHTDAITSLKFD---SACLVTGSYDRTVRIWDLR 634
Cdd:PTZ00420  54 GAIRLENqMRKPPVIK-LKGHTSSILDLQFNpcfSEILASGSEDLTIRVWEIP 105
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 394-529 1.57e-03

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.00  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349   394 MSTHDDFLTCLDFDAPFGTLCTAGYLDHTVKIWDLSKQNKIGELAGHlATINCMQINRDYG-TLVTGGRDAALklwnlnl 472
Cdd:PLN00181 571 MKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTK-ANICCVQFPSESGrSLAFGSADHKV------- 642

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 6322349   473 aqqLYQETQNLTSPTnhidspCvhTFEAHTDEVTALS-LDPSFLVSGSQDRTIRQWDL 529
Cdd:PLN00181 643 ---YYYDLRNPKLPL------C--TMIGHSKTVSYVRfVDSSTLVSSSTDNTLKLWDL 689
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
235-355 2.62e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 40.66  E-value: 2.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322349  235 NSLEFLNIQKNSTLSEIRDIEVEVENLRQKKEKLLGKIANIEQNQLLLEDNLKQIDDRLDFLEEyGLEVIEANSDENAED 314
Cdd:COG4372 101 EELESLQEEAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQE-ELAALEQELQALSEA 179

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 6322349  315 DGMSERKALKNDAIRNEGVTTESISSEASNLPPRRRQQLRD 355
Cdd:COG4372 180 EAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEEL 220
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 392-427 4.05e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 4.05e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 6322349     392 SIMSTHDDFLTCLDFDaPFGTLCTAGYLDHTVKIWD 427
Cdd:smart00320   6 KTLKGHTGPVTSVAFS-PDGKYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 593-632 8.55e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.90  E-value: 8.55e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 6322349    593 LRSGKVIRTLKGHTDAITSLKF--DSACLVTGSYDRTVRIWD 632
Cdd:pfam20426 111 LNDGRMVQSIRQHKDVVSCVAVtsDGSILATGSYDTTVMVWE 152
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 579-612 8.72e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.10  E-value: 8.72e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 6322349    579 LATGTKDGVVRLWDLRSGKVIRTLKGHTDAITSL 612
Cdd:pfam12894  53 LAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCL 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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