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Conserved domains on  [gi|6322419|ref|NP_012493|]
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Mhp1p [Saccharomyces cerevisiae S288C]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
SCOP:  4003523

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
832-1015 1.73e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd00116:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 319  Bit Score: 45.42  E-value: 1.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322419   832 ATERLGLAYNGLSKSQCDDLAKWM-VQSKVTGLDVGFNDLNGKLSsftdAVLGKIQKANEKnvFKFLSLNGTnlrvnehd 910
Cdd:cd00116  138 ALEKLVLGRNRLEGASCEALAKALrANRDLKELNLANNGIGDAGI----RALAEGLKANCN--LEVLDLNNN-------- 203
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322419   911 TFENNEVLKLISVLCYLENLKFLDISNNPaIFPHCVPTLIDFLP-VFVNLVRLHIDYNNLSSTSVVMLAEILPMCSRLny 989
Cdd:cd00116  204 GLTDEGASALAETLASLKSLEVLNLGDNN-LTDAGAAALASALLsPNISLLTLSLSCNDITDDGAKDLAEVLAEKESL-- 280
                        170       180
                 ....*....|....*....|....*.
gi 6322419   990 fsmlgTELDLASSKALAEAVRKSSSL 1015
Cdd:cd00116  281 -----LELDLRGNKFGEEGAQLLAES 301
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
832-1015 1.73e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.42  E-value: 1.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322419   832 ATERLGLAYNGLSKSQCDDLAKWM-VQSKVTGLDVGFNDLNGKLSsftdAVLGKIQKANEKnvFKFLSLNGTnlrvnehd 910
Cdd:cd00116  138 ALEKLVLGRNRLEGASCEALAKALrANRDLKELNLANNGIGDAGI----RALAEGLKANCN--LEVLDLNNN-------- 203
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322419   911 TFENNEVLKLISVLCYLENLKFLDISNNPaIFPHCVPTLIDFLP-VFVNLVRLHIDYNNLSSTSVVMLAEILPMCSRLny 989
Cdd:cd00116  204 GLTDEGASALAETLASLKSLEVLNLGDNN-LTDAGAAALASALLsPNISLLTLSLSCNDITDDGAKDLAEVLAEKESL-- 280
                        170       180
                 ....*....|....*....|....*.
gi 6322419   990 fsmlgTELDLASSKALAEAVRKSSSL 1015
Cdd:cd00116  281 -----LELDLRGNKFGEEGAQLLAES 301
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
788-1022 5.92e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.69  E-value: 5.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322419   788 NRSDMNWDLLTASIALMGGLEEIVISGAKMNSAQFKNFILVACIATERLGLAYNGLSKSQCDDLAKWMVQSKVTGLDVGF 867
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322419   868 NDLNGKLSSFTDAVLGKIQKANEKNVFKFLSLngTNLrvnEHDTFENNEVLKLISVLCYLENLKFLDISNNPaifphcVP 947
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNL--TNL---ESLDLSGNQLTDLPEELANLTNLKELDLSNNQ------LT 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322419   948 TLIDFLPVFVNLVRLHIDYNNLSStsvvmLAEILPMCSRLNYFSM-----------LG-----TELDLASSK--ALAEAV 1009
Cdd:COG4886  150 DLPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLsnnqitdlpepLGnltnlEELDLSGNQltDLPEPL 224
                        250
                 ....*....|...
gi 6322419  1010 RKSSSLMTLDVDY 1022
Cdd:COG4886  225 ANLTNLETLDLSN 237
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
832-1015 1.73e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.42  E-value: 1.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322419   832 ATERLGLAYNGLSKSQCDDLAKWM-VQSKVTGLDVGFNDLNGKLSsftdAVLGKIQKANEKnvFKFLSLNGTnlrvnehd 910
Cdd:cd00116  138 ALEKLVLGRNRLEGASCEALAKALrANRDLKELNLANNGIGDAGI----RALAEGLKANCN--LEVLDLNNN-------- 203
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322419   911 TFENNEVLKLISVLCYLENLKFLDISNNPaIFPHCVPTLIDFLP-VFVNLVRLHIDYNNLSSTSVVMLAEILPMCSRLny 989
Cdd:cd00116  204 GLTDEGASALAETLASLKSLEVLNLGDNN-LTDAGAAALASALLsPNISLLTLSLSCNDITDDGAKDLAEVLAEKESL-- 280
                        170       180
                 ....*....|....*....|....*.
gi 6322419   990 fsmlgTELDLASSKALAEAVRKSSSL 1015
Cdd:cd00116  281 -----LELDLRGNKFGEEGAQLLAES 301
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
920-1028 3.29e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.19  E-value: 3.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322419   920 LISVLCYLEN---LKFLDISNNpAIFPHCVPTLIDFLPVFvNLVRLHIDYNNLSSTSVVMLAEILPMCS-RLNYFSMLGT 995
Cdd:cd00116   70 LQSLLQGLTKgcgLQELDLSDN-ALGPDGCGVLESLLRSS-SLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRN 147
                         90       100       110
                 ....*....|....*....|....*....|...
gi 6322419   996 ELDLASSKALAEAVRKSSSLMTLDvdyvyMPEN 1028
Cdd:cd00116  148 RLEGASCEALAKALRANRDLKELN-----LANN 175
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
788-1022 5.92e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 40.69  E-value: 5.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322419   788 NRSDMNWDLLTASIALMGGLEEIVISGAKMNSAQFKNFILVACIATERLGLAYNGLSKSQCDDLAKWMVQSKVTGLDVGF 867
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322419   868 NDLNGKLSSFTDAVLGKIQKANEKNVFKFLSLngTNLrvnEHDTFENNEVLKLISVLCYLENLKFLDISNNPaifphcVP 947
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELDLSGNEELSNL--TNL---ESLDLSGNQLTDLPEELANLTNLKELDLSNNQ------LT 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322419   948 TLIDFLPVFVNLVRLHIDYNNLSStsvvmLAEILPMCSRLNYFSM-----------LG-----TELDLASSK--ALAEAV 1009
Cdd:COG4886  150 DLPEPLGNLTNLKSLDLSNNQLTD-----LPEELGNLTNLKELDLsnnqitdlpepLGnltnlEELDLSGNQltDLPEPL 224
                        250
                 ....*....|...
gi 6322419  1010 RKSSSLMTLDVDY 1022
Cdd:COG4886  225 ANLTNLETLDLSN 237
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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