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Conserved domains on  [gi|6322582|ref|NP_012656|]
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Iba57p [Saccharomyces cerevisiae S288C]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ygfZ_signature TIGR03317
folate-binding protein YgfZ; YgfZ is a protein from Escherichia coli, homologous to the ...
 320-382 1.71e-16

folate-binding protein YgfZ; YgfZ is a protein from Escherichia coli, homologous to the glycine cleavage system T protein, or aminomethyltransferase, GcvT (TIGR00528). Homologs of YgfZ other than members of the GcvT family share a well-conserved signature region that includes the motif, KGCYxGQE. Elsewhere, sequence diverge and length variation are substantial. Members of this family are mostly bacterial, largely absent from the Firmicutes and otherwise usually present. A few eukaryotic examples are found among the Apicomplexa, and a few archaeal sequences are found. Two functions implicated for this folate-binding protein are RNA modification (a function likely to be conserved) and replication initiation (a function likely to be highly variable). Many members of this family are, at the time of construction of this model, misnamed as the glycine cleavage system T protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


:

Pssm-ID: 274518 [Multi-domain]  Cd Length: 67  Bit Score: 73.73  E-value: 1.71e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6322582    320 RFQKGLIDSTEDyISETLLPLELNFDFFpNTISTNKGCYVGQELTARTYATGILRKRLVPVKL 382
Cdd:TIGR03317   7 RIAAGIPEGGAE-TSGEFIPQELNLDAL-GGVSFDKGCYVGQEVVARMHYRGKVKRRLVPLSL 67
YgfZ super family cl33847
Folate-binding protein YgfZ, synthesis and repair of Fe-S clusters [Posttranslational ...
 50-383 1.35e-14

Folate-binding protein YgfZ, synthesis and repair of Fe-S clusters [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG0354:

Pssm-ID: 440123 [Multi-domain]  Cd Length: 317  Bit Score: 74.54  E-value: 1.35e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322582   50 LENRTYIRIRGPDTVKFLNGLVTSkllphfikkNLTTVEENEvpteegttkvdpiipvpefdarlgnwglynekgiqgpy 129
Cdd:COG0354  20 LSDRGVIRVSGPDALKFLQGQLTN---------DVRALAPGQ-------------------------------------- 52

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322582  130 isrfGLYSAFLNGKGKLITDTIIYPTPVTvseqisnypeYLLELHGNVVDKILHVLQTHKLANKIKFEKIDHsslkTWDV 209
Cdd:COG0354  53 ----ARLAALLTPKGRVLADFRVFRDGDG----------YLLDVPADLAEALLKRLKKYRLRSKVEIEDASD----DLAV 114

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322582  210 EVQFPNLPKDIENPWfDNLLDPMALPKnsidannfAVNVLNSLFNSDPRILgIYVERrtESMSRHYSTFPQSFRVVTSEQ 289
Cdd:COG0354 115 LGLAGPAAAAALAAL-GALADPAAHAV--------ADGGTIRLPRPAPGYL-LIVPA--AAAAALWEALAAGAAPAGSAA 182

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322582  290 VDDLsklfnfnvfdfpfqvnkkasvqvreiRFQKGLIDSTEDYiSETLLPLELNFDFFpNTISTNKGCYVGQELTARTYA 369
Cdd:COG0354 183 WEAL--------------------------RIAAGIPRIGADT-DEDFIPQELNLDAL-GGVSFKKGCYPGQETVARMHY 234

                       330
                ....*....|....
gi 6322582  370 TGILRKRLVPVKLD 383
Cdd:COG0354 235 RGKVKRRLVLLHLD 248
 
Name Accession Description Interval E-value
ygfZ_signature TIGR03317
folate-binding protein YgfZ; YgfZ is a protein from Escherichia coli, homologous to the ...
 320-382 1.71e-16

folate-binding protein YgfZ; YgfZ is a protein from Escherichia coli, homologous to the glycine cleavage system T protein, or aminomethyltransferase, GcvT (TIGR00528). Homologs of YgfZ other than members of the GcvT family share a well-conserved signature region that includes the motif, KGCYxGQE. Elsewhere, sequence diverge and length variation are substantial. Members of this family are mostly bacterial, largely absent from the Firmicutes and otherwise usually present. A few eukaryotic examples are found among the Apicomplexa, and a few archaeal sequences are found. Two functions implicated for this folate-binding protein are RNA modification (a function likely to be conserved) and replication initiation (a function likely to be highly variable). Many members of this family are, at the time of construction of this model, misnamed as the glycine cleavage system T protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274518 [Multi-domain]  Cd Length: 67  Bit Score: 73.73  E-value: 1.71e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6322582    320 RFQKGLIDSTEDyISETLLPLELNFDFFpNTISTNKGCYVGQELTARTYATGILRKRLVPVKL 382
Cdd:TIGR03317   7 RIAAGIPEGGAE-TSGEFIPQELNLDAL-GGVSFDKGCYVGQEVVARMHYRGKVKRRLVPLSL 67
YgfZ COG0354
Folate-binding protein YgfZ, synthesis and repair of Fe-S clusters [Posttranslational ...
 50-383 1.35e-14

Folate-binding protein YgfZ, synthesis and repair of Fe-S clusters [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440123 [Multi-domain]  Cd Length: 317  Bit Score: 74.54  E-value: 1.35e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322582   50 LENRTYIRIRGPDTVKFLNGLVTSkllphfikkNLTTVEENEvpteegttkvdpiipvpefdarlgnwglynekgiqgpy 129
Cdd:COG0354  20 LSDRGVIRVSGPDALKFLQGQLTN---------DVRALAPGQ-------------------------------------- 52

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322582  130 isrfGLYSAFLNGKGKLITDTIIYPTPVTvseqisnypeYLLELHGNVVDKILHVLQTHKLANKIKFEKIDHsslkTWDV 209
Cdd:COG0354  53 ----ARLAALLTPKGRVLADFRVFRDGDG----------YLLDVPADLAEALLKRLKKYRLRSKVEIEDASD----DLAV 114

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322582  210 EVQFPNLPKDIENPWfDNLLDPMALPKnsidannfAVNVLNSLFNSDPRILgIYVERrtESMSRHYSTFPQSFRVVTSEQ 289
Cdd:COG0354 115 LGLAGPAAAAALAAL-GALADPAAHAV--------ADGGTIRLPRPAPGYL-LIVPA--AAAAALWEALAAGAAPAGSAA 182

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322582  290 VDDLsklfnfnvfdfpfqvnkkasvqvreiRFQKGLIDSTEDYiSETLLPLELNFDFFpNTISTNKGCYVGQELTARTYA 369
Cdd:COG0354 183 WEAL--------------------------RIAAGIPRIGADT-DEDFIPQELNLDAL-GGVSFKKGCYPGQETVARMHY 234

                       330
                ....*....|....
gi 6322582  370 TGILRKRLVPVKLD 383
Cdd:COG0354 235 RGKVKRRLVLLHLD 248
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 333-383 6.17e-03

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 38.91  E-value: 6.17e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 6322582  333 ISETLLPLELNFDFFpntISTNKGCYVGQELTARTYATGIlRKRLVPVKLD 383
Cdd:COG0404 248 LDETTTPLEAGLGWA---VKLDKGDFIGKEALLRQKEEGP-RRKLVGLELD 294
 
Name Accession Description Interval E-value
ygfZ_signature TIGR03317
folate-binding protein YgfZ; YgfZ is a protein from Escherichia coli, homologous to the ...
 320-382 1.71e-16

folate-binding protein YgfZ; YgfZ is a protein from Escherichia coli, homologous to the glycine cleavage system T protein, or aminomethyltransferase, GcvT (TIGR00528). Homologs of YgfZ other than members of the GcvT family share a well-conserved signature region that includes the motif, KGCYxGQE. Elsewhere, sequence diverge and length variation are substantial. Members of this family are mostly bacterial, largely absent from the Firmicutes and otherwise usually present. A few eukaryotic examples are found among the Apicomplexa, and a few archaeal sequences are found. Two functions implicated for this folate-binding protein are RNA modification (a function likely to be conserved) and replication initiation (a function likely to be highly variable). Many members of this family are, at the time of construction of this model, misnamed as the glycine cleavage system T protein. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 274518 [Multi-domain]  Cd Length: 67  Bit Score: 73.73  E-value: 1.71e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6322582    320 RFQKGLIDSTEDyISETLLPLELNFDFFpNTISTNKGCYVGQELTARTYATGILRKRLVPVKL 382
Cdd:TIGR03317   7 RIAAGIPEGGAE-TSGEFIPQELNLDAL-GGVSFDKGCYVGQEVVARMHYRGKVKRRLVPLSL 67
YgfZ COG0354
Folate-binding protein YgfZ, synthesis and repair of Fe-S clusters [Posttranslational ...
 50-383 1.35e-14

Folate-binding protein YgfZ, synthesis and repair of Fe-S clusters [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440123 [Multi-domain]  Cd Length: 317  Bit Score: 74.54  E-value: 1.35e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322582   50 LENRTYIRIRGPDTVKFLNGLVTSkllphfikkNLTTVEENEvpteegttkvdpiipvpefdarlgnwglynekgiqgpy 129
Cdd:COG0354  20 LSDRGVIRVSGPDALKFLQGQLTN---------DVRALAPGQ-------------------------------------- 52

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322582  130 isrfGLYSAFLNGKGKLITDTIIYPTPVTvseqisnypeYLLELHGNVVDKILHVLQTHKLANKIKFEKIDHsslkTWDV 209
Cdd:COG0354  53 ----ARLAALLTPKGRVLADFRVFRDGDG----------YLLDVPADLAEALLKRLKKYRLRSKVEIEDASD----DLAV 114

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322582  210 EVQFPNLPKDIENPWfDNLLDPMALPKnsidannfAVNVLNSLFNSDPRILgIYVERrtESMSRHYSTFPQSFRVVTSEQ 289
Cdd:COG0354 115 LGLAGPAAAAALAAL-GALADPAAHAV--------ADGGTIRLPRPAPGYL-LIVPA--AAAAALWEALAAGAAPAGSAA 182

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322582  290 VDDLsklfnfnvfdfpfqvnkkasvqvreiRFQKGLIDSTEDYiSETLLPLELNFDFFpNTISTNKGCYVGQELTARTYA 369
Cdd:COG0354 183 WEAL--------------------------RIAAGIPRIGADT-DEDFIPQELNLDAL-GGVSFKKGCYPGQETVARMHY 234

                       330
                ....*....|....
gi 6322582  370 TGILRKRLVPVKLD 383
Cdd:COG0354 235 RGKVKRRLVLLHLD 248
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 333-383 6.17e-03

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 38.91  E-value: 6.17e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 6322582  333 ISETLLPLELNFDFFpntISTNKGCYVGQELTARTYATGIlRKRLVPVKLD 383
Cdd:COG0404 248 LDETTTPLEAGLGWA---VKLDKGDFIGKEALLRQKEEGP-RRKLVGLELD 294
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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