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Conserved domains on  [gi|398365485|ref|NP_012658|]
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uncharacterized protein YJR124C [Saccharomyces cerevisiae S288C]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
19-431 4.59e-25

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17325:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 375  Bit Score: 105.74  E-value: 4.59e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  19 LWASVFLRLLSYGLTNQVLTLFLNAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFSF 98
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  99 SENFTLLLVFAIFGVISpssdeVGPFKSIEEAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIFVDLLKrtglaat 178
Cdd:cd17325   81 ATSYWQLLLARFLQGLA-----SAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG------- 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 179 dlqcYKLVFLLYAFFAFCKMVIMLLLSDATeldghyehtdcneetaepldvndETAPLMRQATHPEERSNKLSKETVSVL 258
Cdd:cd17325  149 ----YRAPFLVCAALALLALVLALLLLPEP-----------------------RPPPNKRAVSAARLRSGLRLLLRDRRL 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 259 MKLLVIFMVDSLGSGFMTSGWMVYYYSKqFLMGSLALGTLFFITQLVMASSTIPSSIIARCFGPVRATLLVQIPSGIFSI 338
Cdd:cd17325  202 LALFLAIFVLAFAFGALEPFLPLYAAEL-GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 339 LIPMAKNYLPLSILFLnLHFATTAMDVTPRQILLTNIIKPRDLTKVMGVVNIGKTFARCVGPIFTGILANNNYLWLCYII 418
Cdd:cd17325  281 LLPLATSFWLLLLLLA-LLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLA 359
                        410
                 ....*....|...
gi 398365485 419 SGSLVITADLILA 431
Cdd:cd17325  360 AAALLLLAAVLFL 372
 
Name Accession Description Interval E-value
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
19-431 4.59e-25

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 105.74  E-value: 4.59e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  19 LWASVFLRLLSYGLTNQVLTLFLNAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFSF 98
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  99 SENFTLLLVFAIFGVISpssdeVGPFKSIEEAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIFVDLLKrtglaat 178
Cdd:cd17325   81 ATSYWQLLLARFLQGLA-----SAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG------- 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 179 dlqcYKLVFLLYAFFAFCKMVIMLLLSDATeldghyehtdcneetaepldvndETAPLMRQATHPEERSNKLSKETVSVL 258
Cdd:cd17325  149 ----YRAPFLVCAALALLALVLALLLLPEP-----------------------RPPPNKRAVSAARLRSGLRLLLRDRRL 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 259 MKLLVIFMVDSLGSGFMTSGWMVYYYSKqFLMGSLALGTLFFITQLVMASSTIPSSIIARCFGPVRATLLVQIPSGIFSI 338
Cdd:cd17325  202 LALFLAIFVLAFAFGALEPFLPLYAAEL-GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 339 LIPMAKNYLPLSILFLnLHFATTAMDVTPRQILLTNIIKPRDLTKVMGVVNIGKTFARCVGPIFTGILANNNYLWLCYII 418
Cdd:cd17325  281 LLPLATSFWLLLLLLA-LLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLA 359
                        410
                 ....*....|...
gi 398365485 419 SGSLVITADLILA 431
Cdd:cd17325  360 AAALLLLAAVLFL 372
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
16-389 4.84e-17

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 81.94  E-value: 4.84e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  16 IKLLWASVFLRLLSYGLTNQVLTLFLNAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLV 95
Cdd:COG2814   12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  96 FSFSENFTLLLVF-AIFGVISpssdevGPFKSIEEAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIFVDLLKrtg 174
Cdd:COG2814   92 CALAPSLWLLLAArFLQGLGA------GALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG--- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 175 laatdlqcYKLVFLLYAFFAFCKMVIMLLLsdateldghyehtdcneetaepldvndetAPLMRQATHPEERSNKLSKET 254
Cdd:COG2814  163 --------WRWVFLVNAVLALLALLLLLRL-----------------------------LPESRPAARARLRGSLRELLR 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 255 VSVLMKLLVIFMVDSLGSGFMTSgWMVYYYSKQFLMGSLALGTLFFITQLVMASSTIPSSIIARCFGPVRATLLVQIPSG 334
Cdd:COG2814  206 RPRLLLLLLLAFLLGFGFFALFT-YLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLA 284
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 398365485 335 IFSILIPMAKNYLPLSILFLnLHFATTAMDVTPRQILLTNIIKPRDLTKVMGVVN 389
Cdd:COG2814  285 LGLLLLALAGSLWLLLLALF-LLGFGFGLLFPLLQALVAELAPPEARGRASGLYN 338
MFS_1 pfam07690
Major Facilitator Superfamily;
19-400 9.49e-15

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 75.15  E-value: 9.49e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485   19 LWASVFLRLLSYGLTNQVLTLFL-NAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFS 97
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485   98 FSENFTLLLVFAIFGVISpssdeVGPFKSIEEAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIFVDLLKrtglaa 177
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLG-----AGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG------ 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  178 tdlqcYKLVFLLYAFFAFCKMVIMLLLsdateldghyehtdcneetaepldvndETAPLMRQATHPEERSNKLSKETVSV 257
Cdd:pfam07690 150 -----WRAAFLILAILSLLAAVLLLLP---------------------------RPPPESKRPKPAEEARLSLIVAWKAL 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  258 LMKLLVIFMVDSLGSGFMTSGWMVYY--YSKQFLMGSLALGTLFFITQLVMASSTIPSSIIARCFGPVRA---TLLVQIP 332
Cdd:pfam07690 198 LRDPVLWLLLALLLFGFAFFGLLTYLplYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRlllALLLLIL 277
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 398365485  333 SGIFSILIPMAKNYLPLSILFLNLHFATTAMdVTPRQILLTNIIKPRDLTKVMGVVNIGKTFARCVGP 400
Cdd:pfam07690 278 AALGLLLLSLTLSSLWLLLALLLLGFGFGLV-FPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
50-108 8.39e-04

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 41.54  E-value: 8.39e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 398365485   50 KIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFSFSENFTLLLVF 108
Cdd:TIGR00898 128 KVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVF 186
 
Name Accession Description Interval E-value
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
19-431 4.59e-25

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 105.74  E-value: 4.59e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  19 LWASVFLRLLSYGLTNQVLTLFLNAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFSF 98
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  99 SENFTLLLVFAIFGVISpssdeVGPFKSIEEAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIFVDLLKrtglaat 178
Cdd:cd17325   81 ATSYWQLLLARFLQGLA-----SAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG------- 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 179 dlqcYKLVFLLYAFFAFCKMVIMLLLSDATeldghyehtdcneetaepldvndETAPLMRQATHPEERSNKLSKETVSVL 258
Cdd:cd17325  149 ----YRAPFLVCAALALLALVLALLLLPEP-----------------------RPPPNKRAVSAARLRSGLRLLLRDRRL 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 259 MKLLVIFMVDSLGSGFMTSGWMVYYYSKqFLMGSLALGTLFFITQLVMASSTIPSSIIARCFGPVRATLLVQIPSGIFSI 338
Cdd:cd17325  202 LALFLAIFVLAFAFGALEPFLPLYAAEL-GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 339 LIPMAKNYLPLSILFLnLHFATTAMDVTPRQILLTNIIKPRDLTKVMGVVNIGKTFARCVGPIFTGILANNNYLWLCYII 418
Cdd:cd17325  281 LLPLATSFWLLLLLLA-LLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLA 359
                        410
                 ....*....|...
gi 398365485 419 SGSLVITADLILA 431
Cdd:cd17325  360 AAALLLLAAVLFL 372
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
16-389 4.84e-17

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 81.94  E-value: 4.84e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  16 IKLLWASVFLRLLSYGLTNQVLTLFLNAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLV 95
Cdd:COG2814   12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  96 FSFSENFTLLLVF-AIFGVISpssdevGPFKSIEEAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIFVDLLKrtg 174
Cdd:COG2814   92 CALAPSLWLLLAArFLQGLGA------GALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG--- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 175 laatdlqcYKLVFLLYAFFAFCKMVIMLLLsdateldghyehtdcneetaepldvndetAPLMRQATHPEERSNKLSKET 254
Cdd:COG2814  163 --------WRWVFLVNAVLALLALLLLLRL-----------------------------LPESRPAARARLRGSLRELLR 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 255 VSVLMKLLVIFMVDSLGSGFMTSgWMVYYYSKQFLMGSLALGTLFFITQLVMASSTIPSSIIARCFGPVRATLLVQIPSG 334
Cdd:COG2814  206 RPRLLLLLLLAFLLGFGFFALFT-YLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLA 284
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 398365485 335 IFSILIPMAKNYLPLSILFLnLHFATTAMDVTPRQILLTNIIKPRDLTKVMGVVN 389
Cdd:COG2814  285 LGLLLLALAGSLWLLLLALF-LLGFGFGLLFPLLQALVAELAPPEARGRASGLYN 338
MFS_1 pfam07690
Major Facilitator Superfamily;
19-400 9.49e-15

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 75.15  E-value: 9.49e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485   19 LWASVFLRLLSYGLTNQVLTLFL-NAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFS 97
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485   98 FSENFTLLLVFAIFGVISpssdeVGPFKSIEEAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIFVDLLKrtglaa 177
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLG-----AGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG------ 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  178 tdlqcYKLVFLLYAFFAFCKMVIMLLLsdateldghyehtdcneetaepldvndETAPLMRQATHPEERSNKLSKETVSV 257
Cdd:pfam07690 150 -----WRAAFLILAILSLLAAVLLLLP---------------------------RPPPESKRPKPAEEARLSLIVAWKAL 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  258 LMKLLVIFMVDSLGSGFMTSGWMVYY--YSKQFLMGSLALGTLFFITQLVMASSTIPSSIIARCFGPVRA---TLLVQIP 332
Cdd:pfam07690 198 LRDPVLWLLLALLLFGFAFFGLLTYLplYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRlllALLLLIL 277
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 398365485  333 SGIFSILIPMAKNYLPLSILFLNLHFATTAMdVTPRQILLTNIIKPRDLTKVMGVVNIGKTFARCVGP 400
Cdd:pfam07690 278 AALGLLLLSLTLSSLWLLLALLLLGFGFGLV-FPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
19-430 4.98e-14

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 73.23  E-value: 4.98e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  19 LWASVFLRLLSYGLTNQVLTLFLNAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFSF 98
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  99 SENFTLLLVFAIFGVISpssdeVGPFKSIEEAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIFVDLLKRTglaat 178
Cdd:cd06174   81 APSFWLLLLGRFLLGLG-----SGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFG----- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 179 dlqcYKLVFLLYAFFAfckmVIMLLLSdateldghyehtdcneETAEPLDVNDETAPLMRQATHPEERSNKLSKETVSVL 258
Cdd:cd06174  151 ----WRAVFLIAAALA----LLAAILL----------------LLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLW 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 259 MKLLVIFMVDSLGSGFMTsgWMVYYYSKQFLMGSLALGTLFFITQLVMASSTIPSSIIARCFGPVRATLLVQIPSGIFSI 338
Cdd:cd06174  207 LLLLAIFLVNLAYYSFST--LLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGL 284
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 339 LIPMAKNYLPLSILFLNLHFATTAMDVTPRQILLTNIIKPRDLTKVMGVVNIGKTFARCVGPIFTGILANNNYLW-LCYI 417
Cdd:cd06174  285 ALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLtGAFL 364
                        410
                 ....*....|...
gi 398365485 418 ISGSLVITADLIL 430
Cdd:cd06174  365 VLAVLLLLAAILL 377
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
16-431 1.87e-13

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 71.49  E-value: 1.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  16 IKLLWASVFLRLLSYGLTNQVLTLFLN-AINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGL 94
Cdd:cd17329    1 LWVLLIGSFLNRLGFFMVWPFMAIYLHqQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  95 VFSFSENFTLLLVFAIF-----GVISPSSdevgpfksieEAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIFVDL 169
Cdd:cd17329   81 LLGFAHSPWLFAIALVLtgfggGLFEPAS----------EAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 170 LKRtglaatdlqcykLVFLLYAFFAFCKMVIMLLLSDateldghyehtdcneetaepldvndETAPLMRQATHPEERSNK 249
Cdd:cd17329  151 SFR------------LLFLAAAVLFLLAALVLLFLLP-------------------------ETRPKRRAAEKTEILRGY 193
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 250 LSKETVSVLMKLLVIFMVDSLGSGFMTSGwMVYYYSKQFLMGSLALGTLFFITQLVMASSTIPSSIIARCFGPVRATLLV 329
Cdd:cd17329  194 KIVLRDRAFLLFLLASFLISLIYFQLEST-LPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIG 272
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 330 QIPSGIFSILIPMAKNYLPLSILFLNLHFATTAMdVTPRQILLTNIIKPRDLTKVMGVVNIGKTFARCVGPIFTGILANN 409
Cdd:cd17329  273 ILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLV-FPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDL 351
                        410       420
                 ....*....|....*....|..
gi 398365485 410 NYLWLCYIISGSLVITADLILA 431
Cdd:cd17329  352 LGPGLPWLILAALGLIAAALLL 373
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
19-426 4.58e-10

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 61.05  E-value: 4.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  19 LWASVFLRLLSYGL--TNQVLTLFLNA-INMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLV 95
Cdd:COG2223    7 LLLATLAFFLAFGVwyLWSVLAPPLAEeFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  96 FSFSENFTLLLVFAIFGVISpssdeVGPFKSIEEAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIfvdLLKRTGL 175
Cdd:COG2223   87 LALAVSYWLLLLLGLLLGIG-----GGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPL---LIAAFGW 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 176 AAtdlqcyklVFLLYAFFAFCKMVIMLLlsdateldghyehtdcneetaepldvndetapLMRQATHPEERSNKLSKETV 255
Cdd:COG2223  159 RN--------AFLILGILLLVVAVLAWL--------------------------------FLRDPPAGAAAAAKASLRDQ 198
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 256 SVLMK-----LLVIFMVDSLGSGFMTSGWMVYYYSKQFLMGSLALGTLFFITQLVMASSTIPSSIIARCFGPVRATLLVQ 330
Cdd:COG2223  199 LEALRdprfwLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVF 278
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 331 IPSGIFSILIPMAKNYLPLSILFLNLHFATTAMDVTPRQILLTNIIKPRDLTKVMGVVNIGKTFARCVGPIFTGIL--AN 408
Cdd:COG2223  279 ALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALldAT 358
                        410
                 ....*....|....*...
gi 398365485 409 NNYLWLCYIISGSLVITA 426
Cdd:COG2223  359 GSYTAAFLVFAVLALVAL 376
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
14-204 1.78e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 59.53  E-value: 1.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  14 RDIKLLWASVFLRLLSYGLTNQVLTLFL-NAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLS 92
Cdd:COG2211  228 RPFLLLLLAYLLFFLALALVAALLLYYFkYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  93 GLVFSFS--ENFTLLLVFAIFGVISPSSDEVGPFksieeAMIAHLSP-----HNARPE--IYAIHALVGTIGSALGAIIC 163
Cdd:COG2211  308 LLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPW-----AMLADVVDydewkTGRRREglYFGIFTFAIKLGQALAGALA 382
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 398365485 164 GIFVDLLKRTGLAATDLQCYKLVFLLYAFFAFCKMVIMLLL 204
Cdd:COG2211  383 GLLLALFGYVAGAAQSPSALTGIRLLFFLLPAVLLLLAALL 423
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
2-202 1.94e-09

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 59.09  E-value: 1.94e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485   2 APEIFVKFKCASRDIKLLWASVFLRLLSYgLTNQVLTLFLNAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRV 81
Cdd:cd17370  188 KKSKKTSLKKLPKAFWLYLLAVALFALGN-FSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKL 266
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  82 LVYGCAMMLLSGLVFSFSENFTLLLV-FAIFGVispssdEVGPFKSIEEAMIAHLSPHNARPEIYAIHALVGTIGSALGA 160
Cdd:cd17370  267 LILGYLSLALAYLGFALGSSLWLLLLgFILWGL------YMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLAS 340
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 398365485 161 IICGIFVDLLkrtGLAATdlqcyklvFLLYAFFAFCKMVIML 202
Cdd:cd17370  341 LIAGYLWDLI---SPSAA--------FLFSAVLALIALLLLL 371
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
17-433 3.04e-09

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 58.40  E-value: 3.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  17 KLLWASVFLRLLSYGLTNQVLTLFLNAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVY-----GCAMMLL 91
Cdd:cd06173    2 RLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  92 SGLVFSFSENFTLLLVFA-IFGVISPSSDevgpfkSIEEAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIFVDLL 170
Cdd:cd06173   82 ALLALLGSLSLWLLLVLAfLLGIASAFFG------PARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALL 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 171 KRTGLAATDLQCYKLVFLLYAFFAFckmvimlllsdateldghyehtdcneetaEPLDVNDETAPLMRQATHPEERSNKL 250
Cdd:cd06173  156 GPGGAFAINALSFLLSALLLLFIRR-----------------------------PPPAAPGESSSLLLRDLREGLRYLRR 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 251 SKETVSVLMKLLVIFMVdslgsGFMTSGWMVYYYSKQFLMGSLALGTLFFITQLVMASSTIPSSIIARCFGPVRATLLVQ 330
Cdd:cd06173  207 SPLLRLLLLALALFALL-----GGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGA 281
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 331 IPSGIFSILIPMAKNYLPLSILFLNLHFATTAMDVtPRQILLTNIIKPRDLTKVMGVVNIGKTFARCVGPIFTGILANNN 410
Cdd:cd06173  282 LLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNV-PLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL 360
                        410       420
                 ....*....|....*....|...
gi 398365485 411 YLWLCYIISGSLVITADLILACM 433
Cdd:cd06173  361 GLSAVFLLAGALLLLAALLLLLL 383
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
36-204 7.08e-09

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 57.17  E-value: 7.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  36 VLTLFLNAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFSFSENFTLLLVFAIFGVIS 115
Cdd:cd17324   21 LLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLA 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 116 pssdeVGPFKSIEEAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIFVDLLKrtglaatdlqcYKLVFLLYAFFAF 195
Cdd:cd17324  101 -----HGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-----------WRAAFLAIAVLAL 164

                 ....*....
gi 398365485 196 CKMVIMLLL 204
Cdd:cd17324  165 LAALLLWRL 173
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
37-194 1.50e-08

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 56.41  E-value: 1.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  37 LTLFLNAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFSFSENFTLLL--VFAIFGVI 114
Cdd:cd17477  211 LPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALlvLLFLWGGA 290
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 115 SpssdevGPFKSIEEAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIFVDLLKRTGLAATDLqcykLVFLLYAFFA 194
Cdd:cd17477  291 A------GPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLA----AVALLFLLFL 360
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
18-204 2.11e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 55.65  E-value: 2.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  18 LLWASVFLRLLS-YGLTNQVLTLFLNAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRR--VLVYGCAMMLLSGL 94
Cdd:COG2271  184 LLALAYFLVYFAlYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALL 263
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  95 VFSFSENFTLLLVFAIFGVISpssdeVGPFKSIEEAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIFVDllkRTG 174
Cdd:COG2271  264 LLALLPSPALAIALLFLAGFG-----LGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLD---ATG 335
                        170       180       190
                 ....*....|....*....|....*....|
gi 398365485 175 laatdlqcYKLVFLLYAFFAFCKMVIMLLL 204
Cdd:COG2271  336 --------YQAAFLLLAALALLAALLALLL 357
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
19-209 2.52e-08

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 55.68  E-value: 2.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  19 LWASVFLRLLSYGLTNQVLTLFLNAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFSF 98
Cdd:cd17489    1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  99 SENFTLLLVFAI-----FGVISPSSdevgpfksieEAMIAHLSPHNARPEIYAIHALVGTIGSALGAIIcgifvdllkrt 173
Cdd:cd17489   81 ATSVALLLVLRLihgigWGAFTTAA----------ATLVADIIPPSRRGEGIGYYGLATTLAMALGPAL----------- 139
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 398365485 174 GLAATDLQCYKLVFLLYAFFAFCKMVIMLLLSDATE 209
Cdd:cd17489  140 GLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPP 175
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
14-158 3.13e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 55.37  E-value: 3.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  14 RDIKLLWASVFLRLLSYGLTNQVLTLFLNAI-NMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLS 92
Cdd:COG2814  207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG 286
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 398365485  93 GLVFSFSENFTLLLVFAIFGVISpssdeVGPFKSIEEAMIAHLSPHNARPEIYAIHALVGTIGSAL 158
Cdd:COG2814  287 LLLLALAGSLWLLLLALFLLGFG-----FGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
18-440 8.60e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 53.72  E-value: 8.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  18 LLWASVFLRLLSYGLTNQVLTLFLNAI----NMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSG 93
Cdd:COG2271   10 RILALLFLAYFLNYLDRSNLSVAAPPLqadlGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  94 LVFSFSENFTLLLVFAIFGVISpssdeVGPFKSIEEAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIFVDLLKrt 173
Cdd:COG2271   90 LLFGFATSFWQLLLLRFLLGLG-----EAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG-- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 174 glaatdlqcYKLVFLLYAFFAFCKMVIMLLLSdateldghyehtdcneetaepldvndetaplmrqathpeersnklske 253
Cdd:COG2271  163 ---------WRAAFLILGLPGLLLALLRFWLL------------------------------------------------ 185
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 254 tvsvlmkLLVIFMVDSLGSGFMTsgWMVYYYSKQFLMGSLALGTLFFITQLVMASSTIPSSIIARCFGPVRATLLV--QI 331
Cdd:COG2271  186 -------ALAYFLVYFALYGFLT--WLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAigLL 256
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 332 PSGIFSILIPMAKNyLPLSILFLNLHFATTAMDVTPRQILLTNIIKPRDLTKVMGVVNIGKTFARCVGPIFTGILANNNY 411
Cdd:COG2271  257 LAALALLLLALLPS-PALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG 335
                        410       420
                 ....*....|....*....|....*....
gi 398365485 412 LWLCYIISGSLVITAdlILACMFLGVDAK 440
Cdd:COG2271  336 YQAAFLLLAALALLA--ALLALLLLRETR 362
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
21-111 1.33e-07

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 53.32  E-value: 1.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  21 ASVFLRLLSYGLTNQVLTLFL-NAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMML-LSGLVFSF 98
Cdd:cd17471    3 LATLLTGLAGAFVLPYLSLFLtEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLALLAGaLGYLLFAF 82
                         90
                 ....*....|...
gi 398365485  99 SENFTLLLVFAIF 111
Cdd:cd17471   83 LRNYWVLLLVGVV 95
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
21-166 1.80e-07

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 52.95  E-value: 1.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  21 ASVFLRLLSYGLTNQVLTLFLNAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFSFSE 100
Cdd:cd17477    3 LSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD 82
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 398365485 101 NFTLLLVFAIFGVISPSsdevGPFKSIEEAMIAHLSPHNaRPEIYAIHALVGTIGSALGAIICGIF 166
Cdd:cd17477   83 SPWVWFLLRFVMGIGLA----GLFVVSESWLNALATNEN-RGRVLGLYSTVLGLGFALGPLLLALV 143
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
28-406 5.95e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 51.44  E-value: 5.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  28 LSYGLTNQVLTLFL-NAINMTEDKIGLFMSLTLAGDVICSYILTWYADS----WGRRRV-LVYGCAMMLLSGLVFSFSEN 101
Cdd:COG2211   24 LAFGLLSAYLLYFYtDVLGLSAALVGLILLVARLWDAITDPLIGALSDRtrtrWGRRRPwILIGAIPLALSFVLLFTAPD 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 102 F-----------TLLLVFAIFGVISPssdevgPFksieEAMIAHLSPHNA-RPEIYAIHALVGTIGSALGAIICGIFVDL 169
Cdd:COG2211  104 LsptgkliyalvTYLLLGLAYTLVNI------PY----SALGAELTPDYEeRTRLSSWRFAFAGLGGLLASVLPPPLVAA 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 170 LKRTGLAAtdlqcYKLVFLLYAFFAFCKMVIMLLLsdateldghyehtdcneeTAEPLDVNDETAPLMRQATHPeeRSNK 249
Cdd:COG2211  174 FGGDAALG-----YRLTALIFAVLGLLAFLLTFFG------------------TKERPVPEEEKVSLKESLKAL--LKNR 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 250 lsketvsVLMKLLVIFMVDSLGSgFMTSGWMVYYYSKQFLMGSLALGTLFFITQLVMASSTIPSSIIARCFGPVRATLLV 329
Cdd:COG2211  229 -------PFLLLLLAYLLFFLAL-ALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIG 300
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 330 QIPSGIFSILIPMAK-NYLPLSILFLNLHFATTAMDVTPRQILLTNIIKPRDLT-------KVMGVVNIGKTFARCVGPI 401
Cdd:COG2211  301 LLLAALGLLLLFFLGpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKtgrrregLYFGIFTFAIKLGQALAGA 380

                 ....*
gi 398365485 402 FTGIL 406
Cdd:COG2211  381 LAGLL 385
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
18-170 7.08e-07

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 50.58  E-value: 7.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  18 LLWASVFLRLLSYGLTNQVLTLFLNAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFS 97
Cdd:COG0477   18 ALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCG 97
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 398365485  98 FSENFTLLLVFAIF-----GVISPSSdevgpfksieEAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIFVDLL 170
Cdd:COG0477   98 LAPSPELLIAARALqgigaGGLMPGA----------LALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL 165
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
18-433 7.55e-06

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 47.95  E-value: 7.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  18 LLWASVFLRLLSYGLTNQVLTLFLNAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFS 97
Cdd:cd17474    3 AVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  98 FSENFTLLLVF-AIFGVISpssdevGPFKSIEEAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIfvdllkrtgLA 176
Cdd:cd17474   83 LSDSFALLLAGrALQGIGA------AGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGL---------LA 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 177 ATDlqcYKLVFLLYAFFAFCKMVIMLLLSDATeldghyehtdcnEETAEPLDVNDETAPLmRQATHPEERSNKLSKETVS 256
Cdd:cd17474  148 AIS---WRYPFFLLAALIPVAFLAILFLLPEP------------KEKAKSSSATKLRDLK-KALRGRGLLTFLVSAFLYF 211
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 257 VLMKLLVIFMVDSLGSGFMTSGWMvyyyskqflmgslaLGTLFFITQLVMA-SSTIPSSIIARCFGPVRATLLVQIPSGI 335
Cdd:cd17474  212 FLYFAFLTYLPFLLELLYGISPII--------------IGLLFAGWSVLLAlGSLFVGRLLKKRFGARRILVIGLLLYAL 277
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 336 FSILIPMAKNYlPLSILFLNLHFATTAMDVTPRQILLTNIIKPRDLTKVMGVVNIGKTFARCVGPIFTGILANNNYLWLC 415
Cdd:cd17474  278 SLLLLGFVPSL-ALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAP 356
                        410
                 ....*....|....*...
gi 398365485 416 YIISGSLVITADLILACM 433
Cdd:cd17474  357 FLVGAAIALAAAVLLALL 374
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
19-433 2.75e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 46.03  E-value: 2.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  19 LWASVFLRLLSYGLTNQVLTLFLNAINMTEDK---IGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLV 95
Cdd:cd17330    1 LFLVVFLDALGFGIVFPVLPFYVREFNKLGASgyyVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  96 FSFSENFTLLLVFAIFGVISPSSdevgpfKSIEEAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIFVDLLKrtgl 175
Cdd:cd17330   81 LGLSRNLWLLFLARFLDGLTGGN------VSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYG---- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 176 aatdlqcYKLVFLLYAFFAFCKMVIMLLLsdateldghyehtdcneetaepldvndetaplmrqathpeersnklsketV 255
Cdd:cd17330  151 -------YALPFLVAAALALLNLVLVLFF--------------------------------------------------L 173
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 256 SVLMKLLVIFMVDSLGSGFMTSGWMVYYYSKqFLMGSLALGTLFFITQLVMA-SSTIPSSIIARCFGPVRATLLVQIPSG 334
Cdd:cd17330  174 PPLRRLLLVYFLIALAFAGLESVFSLFLKDR-FGFSPSQIGLLLALVGIAGIlAQLLLIPRLAKRLGERKLLRLGLLLAI 252
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 335 IFSILIPMAKN----YLPLSILFLNLHFATTAMdvtprQILLTNIIKPRDLTKVMGVVNIGKTFARCVGPIFTGILANNN 410
Cdd:cd17330  253 IGLLLLPFASSvpllVLAAAILAFGTGIVFPAL-----SALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFL 327
                        410       420
                 ....*....|....*....|...
gi 398365485 411 YLWLCYIIsGSLVITADLILACM 433
Cdd:cd17330  328 GPGVPFLL-AAGLLLIALFLLSL 349
MFS_1 pfam07690
Major Facilitator Superfamily;
261-430 7.67e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 44.72  E-value: 7.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  261 LLVIFMVDSLGSgFMTSGWMVYYYSKQFLMGSLALGTLFFITQLVMASSTIPSSIIARCFGPVRATLLVQIPSGIFSILI 340
Cdd:pfam07690   1 LFLAAFLAALGR-SLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  341 PMAKNYLPLSILFLNLHFATTAMdVTPRQILLTNIIKPRDLTKVMGVVNIGKTFARCVGPIFTGILANNNYLWLCYIISG 420
Cdd:pfam07690  80 LFASSLWLLLVLRVLQGLGAGAL-FPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
                         170
                  ....*....|
gi 398365485  421 SLVITADLIL 430
Cdd:pfam07690 159 ILSLLAAVLL 168
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
14-115 8.86e-05

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 44.51  E-value: 8.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  14 RDIKLLWASVFLRLLS-YGLTNQVLTLFLNAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLS 92
Cdd:cd17316  177 RRTLLLILLWFFISFGyYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGIL 256
                         90       100
                 ....*....|....*....|....*.
gi 398365485  93 GLVFSF---SENFTLLLVFAIFGVIS 115
Cdd:cd17316  257 ALPLFYllsGSPTLLLLLLFILSFFV 282
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
30-204 9.87e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 44.49  E-value: 9.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  30 YGLTNQVLTLFLNAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFSF-SENFTLLLVF 108
Cdd:COG2223  222 IGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALaLGSLWLFLVL 301
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 109 AIFGVISpssdeVGPFKSIEEAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIFVDLlkrTGLaatdlqcYKLVFL 188
Cdd:COG2223  302 FLLLGLA-----LGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDA---TGS-------YTAAFL 366
                        170
                 ....*....|....*.
gi 398365485 189 LYAFFAFCKMVIMLLL 204
Cdd:COG2223  367 VFAVLALVALVLTLLL 382
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
28-203 1.02e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 44.46  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  28 LSYGLTNQVLTLFLNAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVY-GCAMMLLSGLVFSFSENFTLLL 106
Cdd:cd17370   13 ISYEMARSILPLFLVVLGASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVIlGYGLSALAKPLLALAGSWQLVL 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 107 VFAIF-----GVISPSSDevgpfksieeAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIfvdLLKRTGLAatdlq 181
Cdd:cd17370   93 LLRILerlgkGIRTPPRD----------ALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAAL---LLYLLGGN----- 154
                        170       180
                 ....*....|....*....|..
gi 398365485 182 cYKLVFLLYAFFAFCKMVIMLL 203
Cdd:cd17370  155 -YRTIFLLAAIPALLALLILLF 175
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
248-435 1.16e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 44.19  E-value: 1.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 248 NKLSKETVSVLMKLLVIFMVDSLGSGFMTSgwMVYYYSKQFLMGSLALGTLFFITQLVMASSTIPSSIIARCFGPVRATL 327
Cdd:COG2814    2 PATPRRRWLALLALALGAFLSGLGIGIVLP--ALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 328 LVQIPSGIFSILIPMAKNYLPLSILFLnLHFATTAMDVTPRQILLTNIIKPRDLTKVMGVVNIGKTFARCVGPIFTGILA 407
Cdd:COG2814   80 LGLLLFALGSLLCALAPSLWLLLAARF-LQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158
                        170       180
                 ....*....|....*....|....*...
gi 398365485 408 NNNYLWLCYIISGSLVITAdLILACMFL 435
Cdd:COG2814  159 DLFGWRWVFLVNAVLALLA-LLLLLRLL 185
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
21-205 1.94e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 43.35  E-value: 1.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  21 ASVFLRLLSYGLTNQVLTLFLNAINMteDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFSFSE 100
Cdd:cd17489  201 LILFLASIAYGAISTFLPLYAAERGI--SNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAG 278
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 101 NFTLLLVFAI-----FGVISPSSdevgpfksieEAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIFVDLLKrtgl 175
Cdd:cd17489  279 SPWMLLLAAVlyglgFGLLFPAL----------QALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG---- 344
                        170       180       190
                 ....*....|....*....|....*....|
gi 398365485 176 aatdlqcYKLVFLLYAFFAFCKMVIMLLLS 205
Cdd:cd17489  345 -------YRAMFLLAAVVVLLALVLYIFLL 367
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
18-118 2.59e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 42.93  E-value: 2.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  18 LLWASVFLRLLSYGLTNQVLTLFLNAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFS 97
Cdd:cd17478  199 LLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFL 278
                         90       100
                 ....*....|....*....|.
gi 398365485  98 FSENFTLLLVFAIFGVISPSS 118
Cdd:cd17478  279 LTPGIWSYILLVLAGFLLFAS 299
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
18-169 3.79e-04

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 42.57  E-value: 3.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  18 LLWASVFLRLLSYGLTNQVLTLFLNAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLV--YGCAMMLLSGLV 95
Cdd:cd17365  175 LLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLAlfFALGAVSLALLG 254
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398365485  96 FSFSENFTLLLVFAIFGVISPSSDEVGPfksieeAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIFVDL 169
Cdd:cd17365  255 VSPASLVLLYVLVFLAGACVNGAQVGLY------ALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAA 322
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
21-204 4.87e-04

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 42.19  E-value: 4.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  21 ASVFLRLLSYGLTNQVLTLFLNAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFSFSE 100
Cdd:cd17335  205 LVAFLMGFGHGLIYSFLFWHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLE 284
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 101 NFTLLLVFAIFGVISpssdevgpFKSIEEAMIAHLSpHNARPEIYA-----IHALVGTIGSALGAIICGIFVDllkRTGL 175
Cdd:cd17335  285 NPWLVLPIELLHGLT--------FALVWAAAVSYAS-AAAPPGLRAtaqglLQGLYFGLGGGLGSLIGGYLYE---AFGA 352
                        170       180
                 ....*....|....*....|....*....
gi 398365485 176 AATdlqcyklvFLLYAFFAFCKMVIMLLL 204
Cdd:cd17335  353 RTT--------FRFFAIAALAGLLAFFLI 373
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
43-169 5.92e-04

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 42.06  E-value: 5.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  43 AINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFSFSENFTLLLVFAIF-GVIspssdeV 121
Cdd:COG2270  268 VLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAFWILGLLiGLV------M 341
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 398365485 122 GPFKSIEEAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIFVDL 169
Cdd:COG2270  342 GGIQALSRSLLARLIPPGREAEFFGLYALSGKAASFLGPLLFGLVTQL 389
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
50-108 8.39e-04

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 41.54  E-value: 8.39e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 398365485   50 KIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFSFSENFTLLLVF 108
Cdd:TIGR00898 128 KVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVF 186
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
24-169 9.29e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 41.44  E-value: 9.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  24 FLRLLSYGLTNQVLTLFLNAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFSF--SEN 101
Cdd:cd17332  231 LLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFlpPGN 310
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 102 FTLLLVFAIFGVISPSSDEVGPFKSIEEAMIAHLSPHNARPE--IYAIHALVGTIGSALGAIICGIFVDL 169
Cdd:cd17332  311 LVLILVLAVLAGIGYGGANLLPWAMLADVIDYGELKTGKRREgiFYSVMTFFRKLGLALAGALVGLILSL 380
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
13-167 1.02e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 41.19  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485   13 SRDIKLLWASVFLRLLSYGLTNQVLTLFLNAI----NMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAM 88
Cdd:TIGR00895  12 SRYQWRAIILSFLIMLMDGYDLAAMGFAAPAIsaewGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILL 91
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 398365485   89 MLLSGLVFSFSENFTLLLVFAIFGVISpssdeVGPFKSIEEAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIFV 167
Cdd:TIGR00895  92 FSVFTLLCALATNVTQLLILRFLAGLG-----LGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLI 165
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
28-225 1.54e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 40.69  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  28 LSYGLTNQVLTLFLNAINMTEDKIGLFMSLT-LAGdVICSYILTWYADS----WGRRR-VLVYGCAMMLLSGLVFSFSEN 101
Cdd:cd17313   13 FGWALENSYVPPILQTLGLSHALIGFVWTLGpILG-LFVQPLVGSLSDRcnsrIGRRRpFILVGAPLAALGLILIPNAAD 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 102 FTLLL---------VFAIFGVI--SPSSDEV-GPFKsieeAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIfvdL 169
Cdd:cd17313   92 IGLALgdgprtwalVLFVLGIVllDFAMNVCqGPVR----ALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAI---L 164
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 398365485 170 LKRTGLAATDLQCYKLVFLLYAFFAFCKMVIMLLLSDATELDGHYEHTDCNEETAE 225
Cdd:cd17313  165 WDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPSLGE 220
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
28-167 2.30e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 40.22  E-value: 2.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  28 LSYGLTNQVLTLFLNAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFSFSENFTLLLV 107
Cdd:COG0738   22 FATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLL 101
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 398365485 108 -FAIFGVIspssdeVGPFKSIEEAMIAHLSPHNARPEIYAIHALVGtIGSALGAIICGIFV 167
Cdd:COG0738  102 aLFLLGLG------LGLLDVAANPYVAALGPETAASRLNLLHAFFS-LGALLGPLLGGLLI 155
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
24-204 3.21e-03

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 39.49  E-value: 3.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  24 FLRLLSYGLTNQVLTLFLNAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGC--AMMLLSGLVFSFSEN 101
Cdd:cd17335    7 FFFFAALGSLLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSllAAVLFFLSLFFVAQI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485 102 F-TLLLVFAIFGVISpssdevGPFKSIEEAM-IAHLSPHNARpeiYAIHALVGTIGSALGAIICGIFVDLlkrtglaATD 179
Cdd:cd17335   87 FwLLLLLVILGAFFS------APVVPLVDSItLQYLGEERER---YGKQRLWGSIGFGIAALLVGILIDR-------SST 150
                        170       180
                 ....*....|....*....|....*
gi 398365485 180 LQCYKLVFLLYAFFAFCKMVIMLLL 204
Cdd:cd17335  151 YKNYTIAFYVFAVLMLLALLLALKF 175
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
73-170 4.11e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 39.08  E-value: 4.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  73 ADSWGRRRVLVYGCAMMLLSGLVFSFSENFTLLLVF-AIFGV----ISPSSdevgpfksieEAMIAHLSPHNARPEIYAI 147
Cdd:cd17321   55 GDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAArALQGIgaaaIMPAS----------LALIAATFPGERRGRALGL 124
                         90       100
                 ....*....|....*....|...
gi 398365485 148 HALVGTIGSALGAIICGIFVDLL 170
Cdd:cd17321  125 WGAVVGIGAALGPLLGGLLLELF 147
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
59-117 6.11e-03

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 38.72  E-value: 6.11e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  59 LAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFSFSENFTLLLVF-AIFGVISPS 117
Cdd:cd17317   35 FLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLrFLVGVTSAG 94
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
19-169 6.96e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 38.36  E-value: 6.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  19 LWASVFLRLLSYGLTNQVLTLFLNAINMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFSF 98
Cdd:cd17390    1 LYLVGFLDLFGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGF 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398365485  99 SENFTLLLVFAIFgvispssdeVGPFK---SIEEAMIAHLSPHNARPEIYAIHALVGTIGSALGAIICGIFVDL 169
Cdd:cd17390   81 STSLALLFLSRIP---------LGIFKhtqSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAET 145
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
50-115 9.72e-03

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 38.10  E-value: 9.72e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 398365485  50 KIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGLVFSFSENFTLLLVF-AIFGVIS 115
Cdd:cd17379   34 KLDLFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFrFLQGLFG 100
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
19-108 9.96e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 38.05  E-value: 9.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365485  19 LWASvFLRLLSYGLTNQVLTLFLNAI----NMTEDKIGLFMSLTLAGDVICSYILTWYADSWGRRRVLVYGCAMMLLSGL 94
Cdd:cd17371    1 FWAA-FLGWALDGFDLLLLGLVLPALiaefGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTL 79
                         90
                 ....*....|....
gi 398365485  95 VFSFSENFTLLLVF 108
Cdd:cd17371   80 LCGFAQNYWQLLIL 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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