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Conserved domains on  [gi|6322601|ref|NP_012675|]
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putative polyadenylation protein [Saccharomyces cerevisiae S288C]

Protein Classification

HECT-type E3 ubiquitin transferase( domain architecture ID 10009502)

HECT-type E3 ubiquitin transferase such as mammalian E3 ubiquitin-protein ligase E3D that accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5629 COG5629
Predicted metal-binding protein [Function unknown];
4-347 9.98e-157

Predicted metal-binding protein [Function unknown];


:

Pssm-ID: 227916  Cd Length: 321  Bit Score: 442.17  E-value: 9.98e-157
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322601    4 YVVEWLPRIQSISVVVEgwkqveiKNLKDTlmsisgdEEQVEDILLPVEVEEKVDASYKFKNRGKDLEWMTKLRSKSskI 83
Cdd:COG5629   1 MLMEELPSNSRKGVLYL-------PMDKDI-------PKCVGDGLGPFKDHVGLDSLYTPEDRGRTIQLVVRIVTVN--V 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322601   84 YDSSIMsLPdgrWTKEELRSDsDFSIECLNCKQKIISKDNCQVLNDMPSEFWFELMDYWHCHKpDVKEDKSSYTRFETLK 163
Cdd:COG5629  65 YEDKIL-VP---WSDGELARD-DTLPDGFRCKQGNEILHSIRSMNDLPSEGWEELIDCWSCHN-DYCEFKSMLGGPLTPR 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322601  164 PSKNEILIGSSYFQGTPATFENVATTKENDNVLCIKCSAVLGQVTAGSLYKLHKWKLQLIRSGNTyKFPPECDITISLIN 243
Cdd:COG5629 139 PREGGLLLGDSYLLINDADLEGKVAYGPNFKLHCSFCNARLGLPNDSSIRKLFRYNKEVIPNGCT-KIHPHEDLAYSYLN 217

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322601  244 VVKANSCRYVLVKCKTESLLVWIFSVDIGVTLTGNKSFKRAMKLLYTNSVTTINRCLNRQVVEELDFQETSFNAFYSALQ 323
Cdd:COG5629 218 AYFRDKNVLLLEANQARSYEIWHFYRAILITVEPNRSLSRAEAMKVTIKNTDVPPKITKSTESSEDIPVSSFNEFYSKLI 297

                       330       340
                ....*....|....*....|....
gi 6322601  324 HTNALLPSSMKKIGEWTISYTSLI 347
Cdd:COG5629 298 YDNVMSPTSDIKAGGWKISFVTEI 321
 
Name Accession Description Interval E-value
COG5629 COG5629
Predicted metal-binding protein [Function unknown];
4-347 9.98e-157

Predicted metal-binding protein [Function unknown];


Pssm-ID: 227916  Cd Length: 321  Bit Score: 442.17  E-value: 9.98e-157
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322601    4 YVVEWLPRIQSISVVVEgwkqveiKNLKDTlmsisgdEEQVEDILLPVEVEEKVDASYKFKNRGKDLEWMTKLRSKSskI 83
Cdd:COG5629   1 MLMEELPSNSRKGVLYL-------PMDKDI-------PKCVGDGLGPFKDHVGLDSLYTPEDRGRTIQLVVRIVTVN--V 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322601   84 YDSSIMsLPdgrWTKEELRSDsDFSIECLNCKQKIISKDNCQVLNDMPSEFWFELMDYWHCHKpDVKEDKSSYTRFETLK 163
Cdd:COG5629  65 YEDKIL-VP---WSDGELARD-DTLPDGFRCKQGNEILHSIRSMNDLPSEGWEELIDCWSCHN-DYCEFKSMLGGPLTPR 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322601  164 PSKNEILIGSSYFQGTPATFENVATTKENDNVLCIKCSAVLGQVTAGSLYKLHKWKLQLIRSGNTyKFPPECDITISLIN 243
Cdd:COG5629 139 PREGGLLLGDSYLLINDADLEGKVAYGPNFKLHCSFCNARLGLPNDSSIRKLFRYNKEVIPNGCT-KIHPHEDLAYSYLN 217

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322601  244 VVKANSCRYVLVKCKTESLLVWIFSVDIGVTLTGNKSFKRAMKLLYTNSVTTINRCLNRQVVEELDFQETSFNAFYSALQ 323
Cdd:COG5629 218 AYFRDKNVLLLEANQARSYEIWHFYRAILITVEPNRSLSRAEAMKVTIKNTDVPPKITKSTESSEDIPVSSFNEFYSKLI 297

                       330       340
                ....*....|....*....|....
gi 6322601  324 HTNALLPSSMKKIGEWTISYTSLI 347
Cdd:COG5629 298 YDNVMSPTSDIKAGGWKISFVTEI 321
HECT_2 pfam09814
HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding ...
 7-341 8.62e-93

HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding proteins.


Pssm-ID: 462911  Cd Length: 362  Bit Score: 281.27  E-value: 8.62e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322601      7 EWLPRIQSISVVVEGWKQVEI--KNLKDTLMSISGDEEQVEDILLPVEVEEKVDAS-YKFKNRGKDLEWMTKLRSKSSKI 83
Cdd:pfam09814   1 ELLPNIRSISVVVSLPSPLKStrVSLSDDGLLLVRHNGSSETIRLPAEVSVGSSLGrSQLPLPGDELSFRLPLADSSSKF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322601     84 YDSSIMSL------PDGRWTKEELrsDSDFSIECLNCKQKIISKDNCQVLNDMPSEFWFELMDYWHCHKPDVKED--KSS 155
Cdd:pfam09814  81 GSFDLESSlsaqkeLEVPWSAKDL--SPGFSFCCRSCGNVLVESRNIKRWKDLPSENWAEMMDFWHCHKPDDHDHlaTKG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322601    156 YTRFETLKPSKNEILIGSSYFQGTPATFENV----ATTKENDNVLCIKCSAVLGQVTAGSLYKLHKWKLQLIRSGNTYK- 230
Cdd:pfam09814 159 YGANSKLVPQEGDGLVGLTFFLLNESDCQGLklssKPPKDNLSVSCKRCGALLGEVDSLDGLKLYKWALSLQPSEGSDSi 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322601    231 ---FPPECDITISLINVVKANSCRYVLVKCK---TESLLVWIFSVDIGVTL---TGNKSFKRAMKLLYTNSVTTINRC-- 299
Cdd:pfam09814 239 prsFPPESIVAALLLELISRSSTRKFLIQPEdgeTHYLLLWVFNPDLLVSSsssSNSLIAKRAMKVLYKDCIDSEEANsl 318

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 6322601    300 --LNRQVVEELDFQETSFNAFYSALQHTNALLPSSMKKIGEWTI 341
Cdd:pfam09814 319 ldENDSNVEELELPPEVFEELLQLLESSNSLLPPSARKFNEWKV 362
 
Name Accession Description Interval E-value
COG5629 COG5629
Predicted metal-binding protein [Function unknown];
4-347 9.98e-157

Predicted metal-binding protein [Function unknown];


Pssm-ID: 227916  Cd Length: 321  Bit Score: 442.17  E-value: 9.98e-157
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322601    4 YVVEWLPRIQSISVVVEgwkqveiKNLKDTlmsisgdEEQVEDILLPVEVEEKVDASYKFKNRGKDLEWMTKLRSKSskI 83
Cdd:COG5629   1 MLMEELPSNSRKGVLYL-------PMDKDI-------PKCVGDGLGPFKDHVGLDSLYTPEDRGRTIQLVVRIVTVN--V 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322601   84 YDSSIMsLPdgrWTKEELRSDsDFSIECLNCKQKIISKDNCQVLNDMPSEFWFELMDYWHCHKpDVKEDKSSYTRFETLK 163
Cdd:COG5629  65 YEDKIL-VP---WSDGELARD-DTLPDGFRCKQGNEILHSIRSMNDLPSEGWEELIDCWSCHN-DYCEFKSMLGGPLTPR 138

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322601  164 PSKNEILIGSSYFQGTPATFENVATTKENDNVLCIKCSAVLGQVTAGSLYKLHKWKLQLIRSGNTyKFPPECDITISLIN 243
Cdd:COG5629 139 PREGGLLLGDSYLLINDADLEGKVAYGPNFKLHCSFCNARLGLPNDSSIRKLFRYNKEVIPNGCT-KIHPHEDLAYSYLN 217

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322601  244 VVKANSCRYVLVKCKTESLLVWIFSVDIGVTLTGNKSFKRAMKLLYTNSVTTINRCLNRQVVEELDFQETSFNAFYSALQ 323
Cdd:COG5629 218 AYFRDKNVLLLEANQARSYEIWHFYRAILITVEPNRSLSRAEAMKVTIKNTDVPPKITKSTESSEDIPVSSFNEFYSKLI 297

                       330       340
                ....*....|....*....|....
gi 6322601  324 HTNALLPSSMKKIGEWTISYTSLI 347
Cdd:COG5629 298 YDNVMSPTSDIKAGGWKISFVTEI 321
HECT_2 pfam09814
HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding ...
 7-341 8.62e-93

HECT-like Ubiquitin-conjugating enzyme (E2)-binding; HECT_2 is a family of UbcH10-binding proteins.


Pssm-ID: 462911  Cd Length: 362  Bit Score: 281.27  E-value: 8.62e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322601      7 EWLPRIQSISVVVEGWKQVEI--KNLKDTLMSISGDEEQVEDILLPVEVEEKVDAS-YKFKNRGKDLEWMTKLRSKSSKI 83
Cdd:pfam09814   1 ELLPNIRSISVVVSLPSPLKStrVSLSDDGLLLVRHNGSSETIRLPAEVSVGSSLGrSQLPLPGDELSFRLPLADSSSKF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322601     84 YDSSIMSL------PDGRWTKEELrsDSDFSIECLNCKQKIISKDNCQVLNDMPSEFWFELMDYWHCHKPDVKED--KSS 155
Cdd:pfam09814  81 GSFDLESSlsaqkeLEVPWSAKDL--SPGFSFCCRSCGNVLVESRNIKRWKDLPSENWAEMMDFWHCHKPDDHDHlaTKG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322601    156 YTRFETLKPSKNEILIGSSYFQGTPATFENV----ATTKENDNVLCIKCSAVLGQVTAGSLYKLHKWKLQLIRSGNTYK- 230
Cdd:pfam09814 159 YGANSKLVPQEGDGLVGLTFFLLNESDCQGLklssKPPKDNLSVSCKRCGALLGEVDSLDGLKLYKWALSLQPSEGSDSi 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322601    231 ---FPPECDITISLINVVKANSCRYVLVKCK---TESLLVWIFSVDIGVTL---TGNKSFKRAMKLLYTNSVTTINRC-- 299
Cdd:pfam09814 239 prsFPPESIVAALLLELISRSSTRKFLIQPEdgeTHYLLLWVFNPDLLVSSsssSNSLIAKRAMKVLYKDCIDSEEANsl 318

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 6322601    300 --LNRQVVEELDFQETSFNAFYSALQHTNALLPSSMKKIGEWTI 341
Cdd:pfam09814 319 ldENDSNVEELELPPEVFEELLQLLESSNSLLPPSARKFNEWKV 362
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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