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Conserved domains on  [gi|6322636|ref|NP_012709|]
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Doa1p [Saccharomyces cerevisiae S288C]

Protein Classification

WD repeat PLAP family protein( domain architecture ID 10078051)

WD repeat PLAP family protein containing WD40, PFU, and PUL domains, similar to vertebrate phospholipase A-2-activating protein (PLAP or PLAA), a ubiquitin-binding protein involved in protein ubiquitination, sorting and degradation

CATH:  2.130.10.10
Gene Ontology:  GO:0005515|GO:0043130
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PFU pfam09070
PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ...
 333-443 5.86e-61

PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ubiquitin.


:

Pssm-ID: 462670  Cd Length: 111  Bit Score: 199.67  E-value: 5.86e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636    333 PGRKEGQIVVVKSPQGTIEAHQFSNSS--WKKVGDVVGAgaTGNDKKIEFEGKTYDYVFDVDIEDGKPPLKLPINVSDNP 410
Cdd:pfam09070   1 PGKKEGQVKMVREGNGVVEAYQWSAAEqqWEKIGDVVGS--AGSSQKKEYEGKEYDYVFDVDIEDGKPPLKLPYNVGDNP 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 6322636    411 YTAADNFLARYELPMSYRDQVVQFILKNTNGIS 443
Cdd:pfam09070  79 YEAAQKFLARNELPQSYLDQVVNFIIKNTGGVT 111
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 5-288 1.32e-59

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 202.57  E-value: 1.32e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636    5 LSATLKGHDQDVRDVVAVDDSK-VASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYDSEKELLLFGGKDTMINgvpL 83
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIR---L 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636   84 FATSGEDPLYTLIGHQGNVCSLSFQ--DGVVISGSWDKTAKVW--KEGSLVYNLQAHNASVWDakvVSFSENKFL--TAS 157
Cdd:cd00200  78 WDLETGECVRTLTGHTSYVSSVAFSpdGRILSSSSRDKTIKVWdvETGKCLTTLRGHTDWVNS---VAFSPDGTFvaSSS 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636  158 ADKTIKLW--QNDKVIKTFSGiHNDVVRHLAVVDDG-HFISCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGDI 234
Cdd:cd00200 155 QDGTIKLWdlRTGKCVATLTG-HTGEVNSVAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL 233

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6322636  235 V-SCGEDRTVRIWSKENGSLKQVITLPAISIWSVDCMSNG-DIIVGSSDNLVRIFS 288
Cdd:cd00200 234 LaSGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIWD 289
PUL pfam08324
PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated ...
 468-712 2.66e-46

PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain. It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates.


:

Pssm-ID: 462428  Cd Length: 261  Bit Score: 165.58  E-value: 2.66e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636    468 PVKQYLIMENYNPDTIFNGIVKINSNEK---TFDDEILAQIGGALHDIDESW---ELLLSFANTIRSNW--EIKTPAYDI 539
Cdd:pfam08324   1 PQKTYLSFKKANLDKILKKLGEFNGGEPkvlALSPEELATLEALLSFLESSSsasEADIELLLKILTSWppEDRFPALDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636    540 VRLIVKKLPYSSDIKDYIEEGLGNKNIT---------LTMLTVRILVNCFNNENWGvKLLESNqvYKSIFETIDTEFSQA 610
Cdd:pfam08324  81 LRLLALDPRVAAYFAEEEGGKTISTLLSllissglyaLRMLALRLLCNLFSSPLGR-QLLLSH--FDSILSTLASLLSSS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636    611 SAKQSQNLAIAVSTLIFNYSALVTKGNSDL------ELLPIVADAINTkygpleeYQECEEAAYRLTVAYGNLAT----- 679
Cdd:pfam08324 158 LLDSNKNLRIALATLLLNYAVLLHKEKSPLseedqvELLAALLEALST-------EEEDSEALYRLLVALGTLVYapdge 230

                         250       260       270
                  ....*....|....*....|....*....|...
gi 6322636    680 VEPTLRQFANSVTWLANIKRSYGnvPRFKDIFD 712
Cdd:pfam08324 231 VLADLAQVLDAASWVKKAKKKKE--PRIKEVGS 261
 
Name Accession Description Interval E-value
PFU pfam09070
PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ...
 333-443 5.86e-61

PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ubiquitin.


Pssm-ID: 462670  Cd Length: 111  Bit Score: 199.67  E-value: 5.86e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636    333 PGRKEGQIVVVKSPQGTIEAHQFSNSS--WKKVGDVVGAgaTGNDKKIEFEGKTYDYVFDVDIEDGKPPLKLPINVSDNP 410
Cdd:pfam09070   1 PGKKEGQVKMVREGNGVVEAYQWSAAEqqWEKIGDVVGS--AGSSQKKEYEGKEYDYVFDVDIEDGKPPLKLPYNVGDNP 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 6322636    411 YTAADNFLARYELPMSYRDQVVQFILKNTNGIS 443
Cdd:pfam09070  79 YEAAQKFLARNELPQSYLDQVVNFIIKNTGGVT 111
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 5-288 1.32e-59

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 202.57  E-value: 1.32e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636    5 LSATLKGHDQDVRDVVAVDDSK-VASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYDSEKELLLFGGKDTMINgvpL 83
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIR---L 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636   84 FATSGEDPLYTLIGHQGNVCSLSFQ--DGVVISGSWDKTAKVW--KEGSLVYNLQAHNASVWDakvVSFSENKFL--TAS 157
Cdd:cd00200  78 WDLETGECVRTLTGHTSYVSSVAFSpdGRILSSSSRDKTIKVWdvETGKCLTTLRGHTDWVNS---VAFSPDGTFvaSSS 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636  158 ADKTIKLW--QNDKVIKTFSGiHNDVVRHLAVVDDG-HFISCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGDI 234
Cdd:cd00200 155 QDGTIKLWdlRTGKCVATLTG-HTGEVNSVAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL 233

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6322636  235 V-SCGEDRTVRIWSKENGSLKQVITLPAISIWSVDCMSNG-DIIVGSSDNLVRIFS 288
Cdd:cd00200 234 LaSGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
25-286 4.56e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 183.19  E-value: 4.56e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636   25 SKVASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYDSEKELLLFGGKDtmiNGVPLFATSGEDPLYTLIGHQGNVCS 104
Cdd:COG2319 133 KTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDD---GTVRLWDLATGKLLRTLTGHTGAVRS 209

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636  105 LSF-QDG-VVISGSWDKTAKVW--KEGSLVYNLQAHNASVWDakvVSFSEN-KFL-TASADKTIKLW--QNDKVIKTFSG 176
Cdd:COG2319 210 VAFsPDGkLLASGSADGTVRLWdlATGKLLRTLTGHSGSVRS---VAFSPDgRLLaSGSADGTVRLWdlATGELLRTLTG 286

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636  177 iHNDVVRHLAVVDDGHFI-SCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGD-IVSCGEDRTVRIWSKENGSLK 254
Cdd:COG2319 287 -HSGGVNSVAFSPDGKLLaSGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKtLASGSDDGTVRLWDLATGELL 365

                       250       260       270
                ....*....|....*....|....*....|...
gi 6322636  255 QVITLPAISIWSVDCMSNGDIIV-GSSDNLVRI 286
Cdd:COG2319 366 RTLTGHTGAVTSVAFSPDGRTLAsGSADGTVRL 398
PUL pfam08324
PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated ...
 468-712 2.66e-46

PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain. It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates.


Pssm-ID: 462428  Cd Length: 261  Bit Score: 165.58  E-value: 2.66e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636    468 PVKQYLIMENYNPDTIFNGIVKINSNEK---TFDDEILAQIGGALHDIDESW---ELLLSFANTIRSNW--EIKTPAYDI 539
Cdd:pfam08324   1 PQKTYLSFKKANLDKILKKLGEFNGGEPkvlALSPEELATLEALLSFLESSSsasEADIELLLKILTSWppEDRFPALDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636    540 VRLIVKKLPYSSDIKDYIEEGLGNKNIT---------LTMLTVRILVNCFNNENWGvKLLESNqvYKSIFETIDTEFSQA 610
Cdd:pfam08324  81 LRLLALDPRVAAYFAEEEGGKTISTLLSllissglyaLRMLALRLLCNLFSSPLGR-QLLLSH--FDSILSTLASLLSSS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636    611 SAKQSQNLAIAVSTLIFNYSALVTKGNSDL------ELLPIVADAINTkygpleeYQECEEAAYRLTVAYGNLAT----- 679
Cdd:pfam08324 158 LLDSNKNLRIALATLLLNYAVLLHKEKSPLseedqvELLAALLEALST-------EEEDSEALYRLLVALGTLVYapdge 230

                         250       260       270
                  ....*....|....*....|....*....|...
gi 6322636    680 VEPTLRQFANSVTWLANIKRSYGnvPRFKDIFD 712
Cdd:pfam08324 231 VLADLAQVLDAASWVKKAKKKKE--PRIKEVGS 261
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 209-247 8.48e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 8.48e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 6322636     209 TGDVLRTYEGHESFVYCIKLLPNGD-IVSCGEDRTVRIWS 247
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKyLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
210-247 3.02e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 3.02e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 6322636    210 GDVLRTYEGHESFVYCIKLLPNGD-IVSCGEDRTVRIWS 247
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKlLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 58-246 2.46e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.31  E-value: 2.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636    58 NSVC---YDSEKELLLFGG--KDTMINGVPLFATSGED---PLYTLIGHQ--GNVCSLSFQDGVVISGSWDKTAKVWK-- 125
Cdd:PLN00181 484 NLVCaigFDRDGEFFATAGvnKKIKIFECESIIKDGRDihyPVVELASRSklSGICWNSYIKSQVASSNFEGVVQVWDva 563

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636   126 EGSLVYNLQAHNASVWDAKVVSFSENKFLTASADKTIKLWQNDK-----VIKTFSGI-----HNDVVRHLAVvddghfis 195
Cdd:PLN00181 564 RSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQgvsigTIKTKANIccvqfPSESGRSLAF-------- 635

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 6322636   196 CSNDGLIKLVDMHTGDV-LRTYEGHESFVYCIKLLPNGDIVSCGEDRTVRIW 246
Cdd:PLN00181 636 GSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLW 687
 
Name Accession Description Interval E-value
PFU pfam09070
PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ...
 333-443 5.86e-61

PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ubiquitin.


Pssm-ID: 462670  Cd Length: 111  Bit Score: 199.67  E-value: 5.86e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636    333 PGRKEGQIVVVKSPQGTIEAHQFSNSS--WKKVGDVVGAgaTGNDKKIEFEGKTYDYVFDVDIEDGKPPLKLPINVSDNP 410
Cdd:pfam09070   1 PGKKEGQVKMVREGNGVVEAYQWSAAEqqWEKIGDVVGS--AGSSQKKEYEGKEYDYVFDVDIEDGKPPLKLPYNVGDNP 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 6322636    411 YTAADNFLARYELPMSYRDQVVQFILKNTNGIS 443
Cdd:pfam09070  79 YEAAQKFLARNELPQSYLDQVVNFIIKNTGGVT 111
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 5-288 1.32e-59

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 202.57  E-value: 1.32e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636    5 LSATLKGHDQDVRDVVAVDDSK-VASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYDSEKELLLFGGKDTMINgvpL 83
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIR---L 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636   84 FATSGEDPLYTLIGHQGNVCSLSFQ--DGVVISGSWDKTAKVW--KEGSLVYNLQAHNASVWDakvVSFSENKFL--TAS 157
Cdd:cd00200  78 WDLETGECVRTLTGHTSYVSSVAFSpdGRILSSSSRDKTIKVWdvETGKCLTTLRGHTDWVNS---VAFSPDGTFvaSSS 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636  158 ADKTIKLW--QNDKVIKTFSGiHNDVVRHLAVVDDG-HFISCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGDI 234
Cdd:cd00200 155 QDGTIKLWdlRTGKCVATLTG-HTGEVNSVAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL 233

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 6322636  235 V-SCGEDRTVRIWSKENGSLKQVITLPAISIWSVDCMSNG-DIIVGSSDNLVRIFS 288
Cdd:cd00200 234 LaSGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
25-286 4.56e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 183.19  E-value: 4.56e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636   25 SKVASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYDSEKELLLFGGKDtmiNGVPLFATSGEDPLYTLIGHQGNVCS 104
Cdd:COG2319 133 KTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDD---GTVRLWDLATGKLLRTLTGHTGAVRS 209

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636  105 LSF-QDG-VVISGSWDKTAKVW--KEGSLVYNLQAHNASVWDakvVSFSEN-KFL-TASADKTIKLW--QNDKVIKTFSG 176
Cdd:COG2319 210 VAFsPDGkLLASGSADGTVRLWdlATGKLLRTLTGHSGSVRS---VAFSPDgRLLaSGSADGTVRLWdlATGELLRTLTG 286

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636  177 iHNDVVRHLAVVDDGHFI-SCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGD-IVSCGEDRTVRIWSKENGSLK 254
Cdd:COG2319 287 -HSGGVNSVAFSPDGKLLaSGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKtLASGSDDGTVRLWDLATGELL 365

                       250       260       270
                ....*....|....*....|....*....|...
gi 6322636  255 QVITLPAISIWSVDCMSNGDIIV-GSSDNLVRI 286
Cdd:COG2319 366 RTLTGHTGAVTSVAFSPDGRTLAsGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
4-288 1.24e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 178.95  E-value: 1.24e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636    4 QLSATLKGHDQDVRDVVAVDDSKV-ASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYDSEKELLLFGGKDTMINgvp 82
Cdd:COG2319  69 ALLATLLGHTAAVLSVAFSPDGRLlASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVR--- 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636   83 LFATSGEDPLYTLIGHQGNVCSLSF-QDG-VVISGSWDKTAKVW--KEGSLVYNLQAHNASVWDakvVSFSEN-KFL-TA 156
Cdd:COG2319 146 LWDLATGKLLRTLTGHSGAVTSVAFsPDGkLLASGSDDGTVRLWdlATGKLLRTLTGHTGAVRS---VAFSPDgKLLaSG 222

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636  157 SADKTIKLW--QNDKVIKTFSGiHNDVVRHLAVVDDGHFI-SCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGD 233
Cdd:COG2319 223 SADGTVRLWdlATGKLLRTLTG-HSGSVRSVAFSPDGRLLaSGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGK 301

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6322636  234 -IVSCGEDRTVRIWSKENGSLKQVITLPAISIWSVDCMSNGDIIV-GSSDNLVRIFS 288
Cdd:COG2319 302 lLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAsGSDDGTVRLWD 358
PUL pfam08324
PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated ...
 468-712 2.66e-46

PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain. It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates.


Pssm-ID: 462428  Cd Length: 261  Bit Score: 165.58  E-value: 2.66e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636    468 PVKQYLIMENYNPDTIFNGIVKINSNEK---TFDDEILAQIGGALHDIDESW---ELLLSFANTIRSNW--EIKTPAYDI 539
Cdd:pfam08324   1 PQKTYLSFKKANLDKILKKLGEFNGGEPkvlALSPEELATLEALLSFLESSSsasEADIELLLKILTSWppEDRFPALDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636    540 VRLIVKKLPYSSDIKDYIEEGLGNKNIT---------LTMLTVRILVNCFNNENWGvKLLESNqvYKSIFETIDTEFSQA 610
Cdd:pfam08324  81 LRLLALDPRVAAYFAEEEGGKTISTLLSllissglyaLRMLALRLLCNLFSSPLGR-QLLLSH--FDSILSTLASLLSSS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636    611 SAKQSQNLAIAVSTLIFNYSALVTKGNSDL------ELLPIVADAINTkygpleeYQECEEAAYRLTVAYGNLAT----- 679
Cdd:pfam08324 158 LLDSNKNLRIALATLLLNYAVLLHKEKSPLseedqvELLAALLEALST-------EEEDSEALYRLLVALGTLVYapdge 230

                         250       260       270
                  ....*....|....*....|....*....|...
gi 6322636    680 VEPTLRQFANSVTWLANIKRSYGnvPRFKDIFD 712
Cdd:pfam08324 231 VLADLAQVLDAASWVKKAKKKKE--PRIKEVGS 261
WD40 COG2319
WD40 repeat [General function prediction only];
27-247 1.95e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 164.70  E-value: 1.95e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636   27 VASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYDSEKELLLFGGKDtmiNGVPLFATSGEDPLYTLIGHQGNVCSLS 106
Cdd:COG2319 177 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSAD---GTVRLWDLATGKLLRTLTGHSGSVRSVA 253

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636  107 F-QDG-VVISGSWDKTAKVW--KEGSLVYNLQAHNASVWDakvVSFSEN--KFLTASADKTIKLW--QNDKVIKTFSGiH 178
Cdd:COG2319 254 FsPDGrLLASGSADGTVRLWdlATGELLRTLTGHSGGVNS---VAFSPDgkLLASGSDDGTVRLWdlATGKLLRTLTG-H 329

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6322636  179 NDVVRHLAVVDDGHFI-SCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGD-IVSCGEDRTVRIWS 247
Cdd:COG2319 330 TGAVRSVAFSPDGKTLaSGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRtLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 94-294 1.42e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 147.48  E-value: 1.42e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636   94 TLIGHQGNVCSLSFQD--GVVISGSWDKTAKVW--KEGSLVYNLQAHNASVWDAKVVSFSeNKFLTASADKTIKLW--QN 167
Cdd:cd00200   4 TLKGHTGGVTCVAFSPdgKLLATGSGDGTIKVWdlETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWdlET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636  168 DKVIKTFSGiHNDVVRHLAVVDDGHFI-SCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGDIVSCG-EDRTVRI 245
Cdd:cd00200  83 GECVRTLTG-HTSYVSSVAFSPDGRILsSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSsQDGTIKL 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 6322636  246 WSKENGSLKQVITLPAISIWSVDCMSNG-DIIVGSSDNLVRIFSQEKSRW 294
Cdd:cd00200 162 WDLRTGKCVATLTGHTGEVNSVAFSPDGeKLLSSSSDGTIKLWDLSTGKC 211
WD40 COG2319
WD40 repeat [General function prediction only];
27-288 2.14e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 147.37  E-value: 2.14e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636   27 VASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYDSEKELLLFGGKDtmiNGVPLFATSGEDPLYTLIGHQGNVCSLS 106
Cdd:COG2319   9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGD---LTLLLLDAAAGALLATLLGHTAAVLSVA 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636  107 FQ--DGVVISGSWDKTAKVW--KEGSLVYNLQAHNASVWDakvVSFSEN--KFLTASADKTIKLW--QNDKVIKTFSGiH 178
Cdd:COG2319  86 FSpdGRLLASASADGTVRLWdlATGLLLRTLTGHTGAVRS---VAFSPDgkTLASGSADGTVRLWdlATGKLLRTLTG-H 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636  179 NDVVRHLAVVDDGHFI-SCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNGD-IVSCGEDRTVRIWSKENGSLKQV 256
Cdd:COG2319 162 SGAVTSVAFSPDGKLLaSGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKlLASGSADGTVRLWDLATGKLLRT 241

                       250       260       270
                ....*....|....*....|....*....|...
gi 6322636  257 ITLPAISIWSVDCMSNGDIIV-GSSDNLVRIFS 288
Cdd:COG2319 242 LTGHSGSVRSVAFSPDGRLLAsGSADGTVRLWD 274
WD40 COG2319
WD40 repeat [General function prediction only];
27-209 7.40e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 122.33  E-value: 7.40e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636   27 VASVSRDGTVRLWSKDDQWLGTVVYTGQGFLNSVCYDSEKELLLFGGKDtmiNGVPLFATSGEDPLYTLIGHQGNVCSLS 106
Cdd:COG2319 219 LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD---GTVRLWDLATGELLRTLTGHSGGVNSVA 295

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636  107 F-QDG-VVISGSWDKTAKVW--KEGSLVYNLQAHNASVWDakvVSFSEN-KFL-TASADKTIKLW--QNDKVIKTFSGiH 178
Cdd:COG2319 296 FsPDGkLLASGSDDGTVRLWdlATGKLLRTLTGHTGAVRS---VAFSPDgKTLaSGSDDGTVRLWdlATGELLRTLTG-H 371

                       170       180       190
                ....*....|....*....|....*....|..
gi 6322636  179 NDVVRHLAVVDDGHFI-SCSNDGLIKLVDMHT 209
Cdd:COG2319 372 TGAVTSVAFSPDGRTLaSGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-247 3.36e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.41  E-value: 3.36e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636    3 YQLSATLKGHDQDvrdvvavddskVASVSrdgtvrlWSKDDQwlgtvvytgqgflnsvcydsekelllfggkdtmingvp 82
Cdd:cd00200 125 GKCLTTLRGHTDW-----------VNSVA-------FSPDGT-------------------------------------- 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636   83 lfatsgedplytlighqgnvcslsfqdgVVISGSWDKTAKVW--KEGSLVYNLQAHNASVWDakvVSFSEN--KFLTASA 158
Cdd:cd00200 149 ----------------------------FVASSSQDGTIKLWdlRTGKCVATLTGHTGEVNS---VAFSPDgeKLLSSSS 197

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636  159 DKTIKLW--QNDKVIKTFSGiHNDVVRHLAVVDDGHFI-SCSNDGLIKLVDMHTGDVLRTYEGHESFVYCIKLLPNG-DI 234
Cdd:cd00200 198 DGTIKLWdlSTGKCLGTLRG-HENGVNSVAFSPDGYLLaSGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkRL 276

                       250
                ....*....|...
gi 6322636  235 VSCGEDRTVRIWS 247
Cdd:cd00200 277 ASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 213-293 3.50e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.83  E-value: 3.50e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636  213 LRTYEGHESFVYCIKLLPNGD-IVSCGEDRTVRIWSKENGSLKQVITLPAISIWSVDCMSNGD-IIVGSSDNLVRIFSQE 290
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKlLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTyLASGSSDKTIRLWDLE 81


                ...
gi 6322636  291 KSR 293
Cdd:cd00200  82 TGE 84
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 209-247 8.48e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.85  E-value: 8.48e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 6322636     209 TGDVLRTYEGHESFVYCIKLLPNGD-IVSCGEDRTVRIWS 247
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKyLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
210-247 3.02e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 3.02e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 6322636    210 GDVLRTYEGHESFVYCIKLLPNGD-IVSCGEDRTVRIWS 247
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKlLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
91-124 7.79e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 7.79e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 6322636     91 PLYTLIGHQGNVCSLSF-QDG-VVISGSWDKTAKVW 124
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFsPDGkLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 91-125 1.59e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.59e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 6322636      91 PLYTLIGHQGNVCSLSF--QDGVVISGSWDKTAKVWK 125
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 58-246 2.46e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.31  E-value: 2.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636    58 NSVC---YDSEKELLLFGG--KDTMINGVPLFATSGED---PLYTLIGHQ--GNVCSLSFQDGVVISGSWDKTAKVWK-- 125
Cdd:PLN00181 484 NLVCaigFDRDGEFFATAGvnKKIKIFECESIIKDGRDihyPVVELASRSklSGICWNSYIKSQVASSNFEGVVQVWDva 563

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636   126 EGSLVYNLQAHNASVWDAKVVSFSENKFLTASADKTIKLWQNDK-----VIKTFSGI-----HNDVVRHLAVvddghfis 195
Cdd:PLN00181 564 RSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQgvsigTIKTKANIccvqfPSESGRSLAF-------- 635

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 6322636   196 CSNDGLIKLVDMHTGDV-LRTYEGHESFVYCIKLLPNGDIVSCGEDRTVRIW 246
Cdd:PLN00181 636 GSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLW 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 127-165 6.00e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 6.00e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 6322636     127 GSLVYNLQAHNASVWDAKVvSFSENKFLTASADKTIKLW 165
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAF-SPDGKYLASGSDDGTIKLW 39
Nsa1 cd22858
Ribosome Biogenesis Protein Nsa1; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from ...
 179-297 1.08e-03

Ribosome Biogenesis Protein Nsa1; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi is an essential factor for ribosome assembly. In cooperation with the assembly factor Rix7, Nsa1 participates in an early cleavage of the pre-rRNA processing pathway. Rix7 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1 from nucleolar pre-60S particles. The release of Nsa1 from a discrete preribosomal particle may trigger the progression of 60S ribosome biogenesis. Nsa1 is essential for cell viability in yeast. It contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439304  Cd Length: 399  Bit Score: 41.82  E-value: 1.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636  179 NDVVRHLAVVDDGHF-ISCSNDGLIKLVDMH--------TGDVLRTYEG--------HESFVYCIKLLPNGDIVSCGEDR 241
Cdd:cd22858  44 ANRVQRILHISDEKLlVARRLNGSVELYDLSkvpkfdeeEYELLHSIKGllddrskaKDKFVSLIVLESLGIILAATKSG 123

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6322636  242 TVRIWSKENGSLKQV---ITLP--AISIWSVDCMSNGDIIVGSSDNLVRIFSQEKSRWASE 297
Cdd:cd22858 124 LVHIIDLEDDLFKIKpheVKAPleFIQAFDLNPTDPGVFAYGGKENDLKIVELFSDKKKFF 184
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 27-124 1.97e-03

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 41.61  E-value: 1.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322636    27 VASVSRDGTVRLWSKDDqwlGTVVYTGQGFLNSVC--YDSEK-ELLLFGGKDTMINGVPLfaTSGEDPLYTLIGHQGNVC 103
Cdd:PLN00181 591 LASGSDDGSVKLWSINQ---GVSIGTIKTKANICCvqFPSESgRSLAFGSADHKVYYYDL--RNPKLPLCTMIGHSKTVS 665

                         90       100
                 ....*....|....*....|..
gi 6322636   104 SLSFQD-GVVISGSWDKTAKVW 124
Cdd:PLN00181 666 YVRFVDsSTLVSSSTDNTLKLW 687
WD40 pfam00400
WD domain, G-beta repeat;
127-165 2.21e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 2.21e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 6322636    127 GSLVYNLQAHNASVWDAKVvSFSENKFLTASADKTIKLW 165
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAF-SPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 169-206 4.84e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 4.84e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 6322636     169 KVIKTFSGiHNDVVRHLAVVDDG-HFISCSNDGLIKLVD 206
Cdd:smart00320   3 ELLKTLKG-HTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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