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Concise Results
Standard Results
Full Results
Apl2p [Saccharomyces cerevisiae S288C]
Protein Classification
COG5096 family protein ( domain architecture ID 11473802 )
COG5096 family protein
List of domain hits
Name
Accession
Description
Interval
E-value
COG5096
COG5096 Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
6-726
0e+00
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 227427 [Multi-domain]
Cd Length: 757
Bit Score: 681.45
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 6 K RI KKFL KDSIR I A PKIS gkg ELSE L RT G - L V S QYPQTRK DA I KK T I Q QM T LG K D V SSLFPDV L KN I AT I DVE Q K K L V YL 84
Cdd:COG5096 1 M RI MSAF KDSIR K A RNAD --- SVAA L SS G r L E S SNDYKKI DA M KK I I A QM S LG E D M SSLFPDV I KN V AT R DVE L K R L L YL 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 85 Y VMN YA ETH PEL CI LAVNT FIT D A QDPN PL IR CM A I RT M S MI RV DKI L EY I ET P LRRT L H D DN AYVRKTA VIC VAKL FQ L 164
Cdd:COG5096 78 Y LER YA KLK PEL AL LAVNT IQK D L QDPN EE IR GF A L RT L S LL RV KEL L GN I ID P IKKL L T D PH AYVRKTA ALA VAKL YR L 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 165 N KDL CV ELG VVED L VNALD DS N P L VIANA T A A L I EI HN md MD A VDL S SLIQSHVS Q FL L ALNEC - TEW ARI IIL GT L S E Y 243
Cdd:COG5096 158 D KDL YH ELG LIDI L KELVA DS D P I VIANA L A S L A EI DP -- EL A HGY S LEVILRIP Q LD L LSLSV s TEW LLL IIL EV L T E R 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 244 SAKDSLE A Q D IID R VTAH LQH V N PA V V L ATI KVI V R N L PQIEYSS nsl IMKRL S SAF V S L MST P PE - M QYV ALK NI R I I L 322
Cdd:COG5096 236 VPTTPDS A E D FEE R LSPP LQH N N AE V L L IAV KVI L R L L VFLPSNN --- LFLIS S PPL V T L LAK P ES l I QYV LRR NI Q I D L 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 323 E KYPE LL T K ELRI F YVKF ND PL Y V KLEK I D I L V RL V D PS NL K Q ctl L L T EL KE Y AM E -- YEP E F VS R AI Q AL SQ L GI K Y a 400
Cdd:COG5096 313 E VCSK LL D K VKKL F LIEY ND DI Y I KLEK L D Q L T RL A D DQ NL S Q --- I L L EL IY Y IA E nh IDA E M VS E AI K AL GD L AS K A - 388
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 401 q ES F V SKVLDI LLELLE ---- R QDT I KDDCC I SL C -------- DL LR HC P GN -- DKMAKQVC A VFN T W ---- SN P EVLLQ 462
Cdd:COG5096 389 - ES S V NDCISE LLELLE gvwi R GSY I VQEVR I VD C isvirisv LV LR IL P NE yp KILLRGLY A LEE T L elqs RE P RAKSV 467
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 463 S D ia K CNYV WLLG QHPNNFSD L - ESKIN I F I E NFV Q E EALT Q MSL LM TI V R L H A TLTGSML Q ------- S VL ELATQQTH 534
Cdd:COG5096 468 T D -- K YLGA WLLG EFSDIIPR L e PELLR I A I S NFV D E TLEV Q YTI LM SS V K L I A NSIRKAK Q cnseldq D VL RRCFDYVL 545
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 535 EL D V RD M A M MY W R C LS M P NN E SLVND LC QN K -- LPMISNT L EKFSPEVLEK LL ME L ------ GT I S S I YF KP DS N R RKG K 606
Cdd:COG5096 546 VP D L RD R A R MY S R L LS T P LP E FSDPI LC EA K ks NSQFEII L SALLTNQTPE LL EN L rldftl GT L S T I PL KP IF N L RKG A 625
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 607 KYV Q NIVKG K HIE EL ESMAK N EIS S K A NDDV L L D FDER d D VT N TNA G ML N TL T TLG D LD - D L FDFGPS E DATQINT N DT K 685
Cdd:COG5096 626 VVL Q QVTVK K PNA EL GFITG N INP S G A ANED L R D INLN - D SI N SIS G FV N PR T VDE D YF r E L WKMDEF E NKIDESS N NP K 704
730 740 750 760
....*....|....*....|....*....|....*....|...
gi 6322714 686 AVQGLK E L K LGG D SNG I SSGGKNN p DV S GGNIV S QD -- L LD L F 726
Cdd:COG5096 705 KLDDYS E E K SRE D NME I LTPSDDL - EF S SSSLG S KS da L MS L C 746
Name
Accession
Description
Interval
E-value
COG5096
COG5096 Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
6-726
0e+00
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 227427 [Multi-domain]
Cd Length: 757
Bit Score: 681.45
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 6 K RI KKFL KDSIR I A PKIS gkg ELSE L RT G - L V S QYPQTRK DA I KK T I Q QM T LG K D V SSLFPDV L KN I AT I DVE Q K K L V YL 84
Cdd:COG5096 1 M RI MSAF KDSIR K A RNAD --- SVAA L SS G r L E S SNDYKKI DA M KK I I A QM S LG E D M SSLFPDV I KN V AT R DVE L K R L L YL 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 85 Y VMN YA ETH PEL CI LAVNT FIT D A QDPN PL IR CM A I RT M S MI RV DKI L EY I ET P LRRT L H D DN AYVRKTA VIC VAKL FQ L 164
Cdd:COG5096 78 Y LER YA KLK PEL AL LAVNT IQK D L QDPN EE IR GF A L RT L S LL RV KEL L GN I ID P IKKL L T D PH AYVRKTA ALA VAKL YR L 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 165 N KDL CV ELG VVED L VNALD DS N P L VIANA T A A L I EI HN md MD A VDL S SLIQSHVS Q FL L ALNEC - TEW ARI IIL GT L S E Y 243
Cdd:COG5096 158 D KDL YH ELG LIDI L KELVA DS D P I VIANA L A S L A EI DP -- EL A HGY S LEVILRIP Q LD L LSLSV s TEW LLL IIL EV L T E R 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 244 SAKDSLE A Q D IID R VTAH LQH V N PA V V L ATI KVI V R N L PQIEYSS nsl IMKRL S SAF V S L MST P PE - M QYV ALK NI R I I L 322
Cdd:COG5096 236 VPTTPDS A E D FEE R LSPP LQH N N AE V L L IAV KVI L R L L VFLPSNN --- LFLIS S PPL V T L LAK P ES l I QYV LRR NI Q I D L 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 323 E KYPE LL T K ELRI F YVKF ND PL Y V KLEK I D I L V RL V D PS NL K Q ctl L L T EL KE Y AM E -- YEP E F VS R AI Q AL SQ L GI K Y a 400
Cdd:COG5096 313 E VCSK LL D K VKKL F LIEY ND DI Y I KLEK L D Q L T RL A D DQ NL S Q --- I L L EL IY Y IA E nh IDA E M VS E AI K AL GD L AS K A - 388
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 401 q ES F V SKVLDI LLELLE ---- R QDT I KDDCC I SL C -------- DL LR HC P GN -- DKMAKQVC A VFN T W ---- SN P EVLLQ 462
Cdd:COG5096 389 - ES S V NDCISE LLELLE gvwi R GSY I VQEVR I VD C isvirisv LV LR IL P NE yp KILLRGLY A LEE T L elqs RE P RAKSV 467
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 463 S D ia K CNYV WLLG QHPNNFSD L - ESKIN I F I E NFV Q E EALT Q MSL LM TI V R L H A TLTGSML Q ------- S VL ELATQQTH 534
Cdd:COG5096 468 T D -- K YLGA WLLG EFSDIIPR L e PELLR I A I S NFV D E TLEV Q YTI LM SS V K L I A NSIRKAK Q cnseldq D VL RRCFDYVL 545
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 535 EL D V RD M A M MY W R C LS M P NN E SLVND LC QN K -- LPMISNT L EKFSPEVLEK LL ME L ------ GT I S S I YF KP DS N R RKG K 606
Cdd:COG5096 546 VP D L RD R A R MY S R L LS T P LP E FSDPI LC EA K ks NSQFEII L SALLTNQTPE LL EN L rldftl GT L S T I PL KP IF N L RKG A 625
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 607 KYV Q NIVKG K HIE EL ESMAK N EIS S K A NDDV L L D FDER d D VT N TNA G ML N TL T TLG D LD - D L FDFGPS E DATQINT N DT K 685
Cdd:COG5096 626 VVL Q QVTVK K PNA EL GFITG N INP S G A ANED L R D INLN - D SI N SIS G FV N PR T VDE D YF r E L WKMDEF E NKIDESS N NP K 704
730 740 750 760
....*....|....*....|....*....|....*....|...
gi 6322714 686 AVQGLK E L K LGG D SNG I SSGGKNN p DV S GGNIV S QD -- L LD L F 726
Cdd:COG5096 705 KLDDYS E E K SRE D NME I LTPSDDL - EF S SSSLG S KS da L MS L C 746
Adaptin_N
pfam01602 Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
25-553
1.18e-151
Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.
Pssm-ID: 396262 [Multi-domain]
Cd Length: 523
Bit Score: 451.30
E-value: 1.18e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 25 K GELS EL RTG L V S Q -- Y P QTR K D A I KK TIQQMT LG K D V S S LF PD V L K NI A TI D VEQ K K L V YLY V M NY AE TH P E L C IL AV N 102
Cdd:pfam01602 3 K RIQQ EL ARI L N S F rd D P RKK K N A V KK LLYLIM LG E D I S F LF FE V V K LV A SK D FTL K R L G YLY L M LL AE ES P D L A IL VT N 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 103 TFIT D A Q D PN P LIR CM A I RT M S M IRV DKILEYIETPLRRT L H D DNA YVRK T A VICVA KL FQLNK DL CVEL gv V ED L VNA L 182
Cdd:pfam01602 83 SIQK D L Q S PN Q LIR GL A L RT L S C IRV PELARDLAPDIKKL L V D RSP YVRK K A ALAIL KL YRKSP DL VRDF -- V PE L KEL L 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 183 D D SN P L V IAN A T A A L I EI - H N MDM davd LSS L IQSHVSQFLLA L NECTE W ARII IL GT L SEYSAK D S L EAQDIIDRVTAH 261
Cdd:pfam01602 161 S D KD P G V QSA A V A L L Y EI c K N DRL ---- YLK L LPLLFRRLCNL L GVLNP W LQVK IL RL L TRLAPL D P L LPKELLEDLLNL 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 262 LQ HV N P AV VLA T IKV IV RNL P QI E yssnsl IMKRLSS A FVS L M S T P P E - MQ YVAL K N IRI I LE K Y P - ELLTKE L R IF YV K 339
Cdd:pfam01602 237 LQ NS N N AV LYE T ANT IV HLA P AP E ------ LIVLAVN A LGR L L S S P D E n LR YVAL R N LNK I VM K E P k AVQHLD L I IF CL K 310
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 340 FN D PLYVK L EKI D I L VR LV DP SN L K Q ctl LLT EL KE Y AM E Y - E P E F VSRAIQ A LSQ L GI K YAQE sf VSKV LD I LL E LL ER 418
Cdd:pfam01602 311 TD D DISIR L RAL D L L YA LV NE SN V K E --- IVK EL LK Y VH E I a D P D F KIELVR A IGR L AE K FPTD -- AEWY LD V LL D LL SL 385
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 419 QDT - IK D DCCISLC D LLRHC P GN - DKMAKQV C AVFNTWSN PE vllqsdi A KCNYV W L LG QHPNNFSDLE S --- KINIFI E 493
Cdd:pfam01602 386 AGS y VV D EIVEVIR D IIQNV P EL r EYILEHL C ELLEDIES PE ------- A LAAAL W I LG EYGELIPNGS S ppd LLRSIL E 458
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6322714 494 N FV Q E E A LTQMSL L MTIVR L HA T ----- LTGSML Q SV L E LATQ QTHE L D VRD M A MM Y W R C LS MPN 553
Cdd:pfam01602 459 V FV L E S A KVRAAA L TALAK L GL T speet TQNLII Q LL L T LATQ DSLD L E VRD R A VE Y L R L LS LAD 523
PTZ00429
PTZ00429 beta-adaptin; Provisional
25-550
9.53e-110
beta-adaptin; Provisional
Pssm-ID: 240415 [Multi-domain]
Cd Length: 746
Bit Score: 350.00
E-value: 9.53e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 25 K GE LS EL RTG L VSQYPQTR K D A I K KT I QQ MT L G K DVS S LF P DV L K NIATI D V E Q KKLVYLYV MNY A ETH PE LCI LAVNTF 104
Cdd:PTZ00429 31 R GE GA EL QND L NGTDSYRK K A A V K RI I AN MT M G R DVS Y LF V DV V K LAPST D L E L KKLVYLYV LST A RLQ PE KAL LAVNTF 110
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 105 IT D AQDPN P LI R CM A I RTM SM IRV DKI LEY IET PLRR TLH D DNA YVRKTA VICVA KLF QLNKD L CVELGVVE DLV NA L D D 184
Cdd:PTZ00429 111 LQ D TTNSS P VV R AL A V RTM MC IRV SSV LEY TLE PLRR AVA D PDP YVRKTA AMGLG KLF HDDMQ L FYQQDFKK DLV EL L N D 190
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 185 S NP L V IA NA T A ALI E IHNMDMDAVDL S S liq SH V SQFLLA L N EC T EW ARII IL GT L SEYSAK D SLE A QDIID RV TAHLQ H 264
Cdd:PTZ00429 191 N NP V V AS NA A A IVC E VNDYGSEKIES S N --- EW V NRLVYH L P EC N EW GQLY IL EL L AAQRPS D KES A ETLLT RV LPRMS H 267
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 265 V NPAVV LAT IKV IVRNLPQIEYSSNSLIMK R LSS A FVS L MSTPP E M QY VAL KNI RII L EKY P E LL TKE L RI FYV KFN DP L 344
Cdd:PTZ00429 268 Q NPAVV MGA IKV VANLASRCSQELIERCTV R VNT A LLT L SRRDA E T QY IVC KNI HAL L VIF P N LL RTN L DS FYV RYS DP P 347
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 345 Y VKLEK IDI L VR LV D PS NLKQ ctl L L T EL K EYA MEYEPE FV SRAIQ A LSQ L G IK Y aq E S FVSKVLDI LL ELLE R QDTIKD 424
Cdd:PTZ00429 348 F VKLEK LRL L LK LV T PS VAPE --- I L K EL A EYA SGVDMV FV VEVVR A IAS L A IK V -- D S VAPDCANL LL QIVD R RPELLP 422
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 425 DCCISLC D LL R HC P ------------ G N D KMAKQV cavfntwsnpevllqsdi AK CNYV W L LG QHPNNFSDLESK I NI FI 492
Cdd:PTZ00429 423 QVVTAAK D IV R KY P ellmldtlvtdy G A D EVVEEE ------------------ AK VSLL W M LG EYCDFIENGKDI I QR FI 484
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6322714 493 ENFVQE E ALT Q MSL L MTI V RLHATLTGS M --- L QS VLE LA T QQTHEL DVRD M A MM YWR C LS 550
Cdd:PTZ00429 485 DTIMEH E QRV Q LAI L SAA V KMFLRDPQG M epq L NR VLE TV T THSDDP DVRD R A FA YWR L LS 545
Name
Accession
Description
Interval
E-value
COG5096
COG5096 Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
6-726
0e+00
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 227427 [Multi-domain]
Cd Length: 757
Bit Score: 681.45
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 6 K RI KKFL KDSIR I A PKIS gkg ELSE L RT G - L V S QYPQTRK DA I KK T I Q QM T LG K D V SSLFPDV L KN I AT I DVE Q K K L V YL 84
Cdd:COG5096 1 M RI MSAF KDSIR K A RNAD --- SVAA L SS G r L E S SNDYKKI DA M KK I I A QM S LG E D M SSLFPDV I KN V AT R DVE L K R L L YL 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 85 Y VMN YA ETH PEL CI LAVNT FIT D A QDPN PL IR CM A I RT M S MI RV DKI L EY I ET P LRRT L H D DN AYVRKTA VIC VAKL FQ L 164
Cdd:COG5096 78 Y LER YA KLK PEL AL LAVNT IQK D L QDPN EE IR GF A L RT L S LL RV KEL L GN I ID P IKKL L T D PH AYVRKTA ALA VAKL YR L 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 165 N KDL CV ELG VVED L VNALD DS N P L VIANA T A A L I EI HN md MD A VDL S SLIQSHVS Q FL L ALNEC - TEW ARI IIL GT L S E Y 243
Cdd:COG5096 158 D KDL YH ELG LIDI L KELVA DS D P I VIANA L A S L A EI DP -- EL A HGY S LEVILRIP Q LD L LSLSV s TEW LLL IIL EV L T E R 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 244 SAKDSLE A Q D IID R VTAH LQH V N PA V V L ATI KVI V R N L PQIEYSS nsl IMKRL S SAF V S L MST P PE - M QYV ALK NI R I I L 322
Cdd:COG5096 236 VPTTPDS A E D FEE R LSPP LQH N N AE V L L IAV KVI L R L L VFLPSNN --- LFLIS S PPL V T L LAK P ES l I QYV LRR NI Q I D L 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 323 E KYPE LL T K ELRI F YVKF ND PL Y V KLEK I D I L V RL V D PS NL K Q ctl L L T EL KE Y AM E -- YEP E F VS R AI Q AL SQ L GI K Y a 400
Cdd:COG5096 313 E VCSK LL D K VKKL F LIEY ND DI Y I KLEK L D Q L T RL A D DQ NL S Q --- I L L EL IY Y IA E nh IDA E M VS E AI K AL GD L AS K A - 388
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 401 q ES F V SKVLDI LLELLE ---- R QDT I KDDCC I SL C -------- DL LR HC P GN -- DKMAKQVC A VFN T W ---- SN P EVLLQ 462
Cdd:COG5096 389 - ES S V NDCISE LLELLE gvwi R GSY I VQEVR I VD C isvirisv LV LR IL P NE yp KILLRGLY A LEE T L elqs RE P RAKSV 467
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 463 S D ia K CNYV WLLG QHPNNFSD L - ESKIN I F I E NFV Q E EALT Q MSL LM TI V R L H A TLTGSML Q ------- S VL ELATQQTH 534
Cdd:COG5096 468 T D -- K YLGA WLLG EFSDIIPR L e PELLR I A I S NFV D E TLEV Q YTI LM SS V K L I A NSIRKAK Q cnseldq D VL RRCFDYVL 545
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 535 EL D V RD M A M MY W R C LS M P NN E SLVND LC QN K -- LPMISNT L EKFSPEVLEK LL ME L ------ GT I S S I YF KP DS N R RKG K 606
Cdd:COG5096 546 VP D L RD R A R MY S R L LS T P LP E FSDPI LC EA K ks NSQFEII L SALLTNQTPE LL EN L rldftl GT L S T I PL KP IF N L RKG A 625
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 607 KYV Q NIVKG K HIE EL ESMAK N EIS S K A NDDV L L D FDER d D VT N TNA G ML N TL T TLG D LD - D L FDFGPS E DATQINT N DT K 685
Cdd:COG5096 626 VVL Q QVTVK K PNA EL GFITG N INP S G A ANED L R D INLN - D SI N SIS G FV N PR T VDE D YF r E L WKMDEF E NKIDESS N NP K 704
730 740 750 760
....*....|....*....|....*....|....*....|...
gi 6322714 686 AVQGLK E L K LGG D SNG I SSGGKNN p DV S GGNIV S QD -- L LD L F 726
Cdd:COG5096 705 KLDDYS E E K SRE D NME I LTPSDDL - EF S SSSLG S KS da L MS L C 746
Adaptin_N
pfam01602 Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
25-553
1.18e-151
Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.
Pssm-ID: 396262 [Multi-domain]
Cd Length: 523
Bit Score: 451.30
E-value: 1.18e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 25 K GELS EL RTG L V S Q -- Y P QTR K D A I KK TIQQMT LG K D V S S LF PD V L K NI A TI D VEQ K K L V YLY V M NY AE TH P E L C IL AV N 102
Cdd:pfam01602 3 K RIQQ EL ARI L N S F rd D P RKK K N A V KK LLYLIM LG E D I S F LF FE V V K LV A SK D FTL K R L G YLY L M LL AE ES P D L A IL VT N 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 103 TFIT D A Q D PN P LIR CM A I RT M S M IRV DKILEYIETPLRRT L H D DNA YVRK T A VICVA KL FQLNK DL CVEL gv V ED L VNA L 182
Cdd:pfam01602 83 SIQK D L Q S PN Q LIR GL A L RT L S C IRV PELARDLAPDIKKL L V D RSP YVRK K A ALAIL KL YRKSP DL VRDF -- V PE L KEL L 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 183 D D SN P L V IAN A T A A L I EI - H N MDM davd LSS L IQSHVSQFLLA L NECTE W ARII IL GT L SEYSAK D S L EAQDIIDRVTAH 261
Cdd:pfam01602 161 S D KD P G V QSA A V A L L Y EI c K N DRL ---- YLK L LPLLFRRLCNL L GVLNP W LQVK IL RL L TRLAPL D P L LPKELLEDLLNL 236
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 262 LQ HV N P AV VLA T IKV IV RNL P QI E yssnsl IMKRLSS A FVS L M S T P P E - MQ YVAL K N IRI I LE K Y P - ELLTKE L R IF YV K 339
Cdd:pfam01602 237 LQ NS N N AV LYE T ANT IV HLA P AP E ------ LIVLAVN A LGR L L S S P D E n LR YVAL R N LNK I VM K E P k AVQHLD L I IF CL K 310
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 340 FN D PLYVK L EKI D I L VR LV DP SN L K Q ctl LLT EL KE Y AM E Y - E P E F VSRAIQ A LSQ L GI K YAQE sf VSKV LD I LL E LL ER 418
Cdd:pfam01602 311 TD D DISIR L RAL D L L YA LV NE SN V K E --- IVK EL LK Y VH E I a D P D F KIELVR A IGR L AE K FPTD -- AEWY LD V LL D LL SL 385
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 419 QDT - IK D DCCISLC D LLRHC P GN - DKMAKQV C AVFNTWSN PE vllqsdi A KCNYV W L LG QHPNNFSDLE S --- KINIFI E 493
Cdd:pfam01602 386 AGS y VV D EIVEVIR D IIQNV P EL r EYILEHL C ELLEDIES PE ------- A LAAAL W I LG EYGELIPNGS S ppd LLRSIL E 458
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6322714 494 N FV Q E E A LTQMSL L MTIVR L HA T ----- LTGSML Q SV L E LATQ QTHE L D VRD M A MM Y W R C LS MPN 553
Cdd:pfam01602 459 V FV L E S A KVRAAA L TALAK L GL T speet TQNLII Q LL L T LATQ DSLD L E VRD R A VE Y L R L LS LAD 523
PTZ00429
PTZ00429 beta-adaptin; Provisional
25-550
9.53e-110
beta-adaptin; Provisional
Pssm-ID: 240415 [Multi-domain]
Cd Length: 746
Bit Score: 350.00
E-value: 9.53e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 25 K GE LS EL RTG L VSQYPQTR K D A I K KT I QQ MT L G K DVS S LF P DV L K NIATI D V E Q KKLVYLYV MNY A ETH PE LCI LAVNTF 104
Cdd:PTZ00429 31 R GE GA EL QND L NGTDSYRK K A A V K RI I AN MT M G R DVS Y LF V DV V K LAPST D L E L KKLVYLYV LST A RLQ PE KAL LAVNTF 110
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 105 IT D AQDPN P LI R CM A I RTM SM IRV DKI LEY IET PLRR TLH D DNA YVRKTA VICVA KLF QLNKD L CVELGVVE DLV NA L D D 184
Cdd:PTZ00429 111 LQ D TTNSS P VV R AL A V RTM MC IRV SSV LEY TLE PLRR AVA D PDP YVRKTA AMGLG KLF HDDMQ L FYQQDFKK DLV EL L N D 190
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 185 S NP L V IA NA T A ALI E IHNMDMDAVDL S S liq SH V SQFLLA L N EC T EW ARII IL GT L SEYSAK D SLE A QDIID RV TAHLQ H 264
Cdd:PTZ00429 191 N NP V V AS NA A A IVC E VNDYGSEKIES S N --- EW V NRLVYH L P EC N EW GQLY IL EL L AAQRPS D KES A ETLLT RV LPRMS H 267
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 265 V NPAVV LAT IKV IVRNLPQIEYSSNSLIMK R LSS A FVS L MSTPP E M QY VAL KNI RII L EKY P E LL TKE L RI FYV KFN DP L 344
Cdd:PTZ00429 268 Q NPAVV MGA IKV VANLASRCSQELIERCTV R VNT A LLT L SRRDA E T QY IVC KNI HAL L VIF P N LL RTN L DS FYV RYS DP P 347
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 345 Y VKLEK IDI L VR LV D PS NLKQ ctl L L T EL K EYA MEYEPE FV SRAIQ A LSQ L G IK Y aq E S FVSKVLDI LL ELLE R QDTIKD 424
Cdd:PTZ00429 348 F VKLEK LRL L LK LV T PS VAPE --- I L K EL A EYA SGVDMV FV VEVVR A IAS L A IK V -- D S VAPDCANL LL QIVD R RPELLP 422
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 425 DCCISLC D LL R HC P ------------ G N D KMAKQV cavfntwsnpevllqsdi AK CNYV W L LG QHPNNFSDLESK I NI FI 492
Cdd:PTZ00429 423 QVVTAAK D IV R KY P ellmldtlvtdy G A D EVVEEE ------------------ AK VSLL W M LG EYCDFIENGKDI I QR FI 484
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6322714 493 ENFVQE E ALT Q MSL L MTI V RLHATLTGS M --- L QS VLE LA T QQTHEL DVRD M A MM YWR C LS 550
Cdd:PTZ00429 485 DTIMEH E QRV Q LAI L SAA V KMFLRDPQG M epq L NR VLE TV T THSDDP DVRD R A FA YWR L LS 545
Cnd1
pfam12717 non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of ...
114-278
7.73e-62
non-SMC mitotic condensation complex subunit 1; The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis.
Pssm-ID: 463677 [Multi-domain]
Cd Length: 162
Bit Score: 204.23
E-value: 7.73e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 114 LIR CM AIRTM SM IR VDKIL EY IET PL R R T L H D DNA YVRKTA VI CVAKL fq LNK D LCVEL G VVED L VNA L D D S NP L V I ANA 193
Cdd:pfam12717 1 LIR AL AIRTM GC IR FPNLV EY LTE PL Y R R L K D EDP YVRKTA AM CVAKL -- ILP D MVKVK G FISE L AKL L E D P NP M V V ANA 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 194 T AAL I EI HNM D MD A V dl SS L IQSHV S QFLL ALNEC T EW AR I I IL GT L SE Y SA KD SL EA QDIIDRVTAH LQH V N P AVVL AT 273
Cdd:pfam12717 79 L AAL T EI SEK D PN A I -- YN L LPDII S KLSD ALNEC S EW GQ I Y IL DF L AS Y IP KD KQ EA ESLVEKLCPR LQH A N S AVVL RA 156
....*
gi 6322714 274 IKVI V 278
Cdd:pfam12717 157 IKVI L 161
HEAT
COG1413 HEAT repeat [General function prediction only];
109-210
6.58e-09
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain]
Cd Length: 137
Bit Score: 55.02
E-value: 6.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 109 Q D PN P LI R CM A I R TMSMIRVDKILE yiet P L RRT L H D DNAY VR KT A VICVAKLFQLN kdlcvelg V V ED L VN AL D D SN P L 188
Cdd:COG1413 26 A D ED P DV R AA A A R ALGRLGDPRAVP ---- A L LEA L K D PDPE VR AA A AEALGRIGDPE -------- A V PA L IA AL K D ED P E 93
90 100
....*....|....*....|..
gi 6322714 189 V IAN A TA AL IEIH nm D MD AV DL 210
Cdd:COG1413 94 V RRA A AE AL GRLG -- D PA AV PA 113
HEAT
COG1413 HEAT repeat [General function prediction only];
115-279
8.96e-09
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain]
Cd Length: 137
Bit Score: 54.63
E-value: 8.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 115 I R CM A I R TMSMIRVDKILE yiet P L RRT L H D DNAY VR KT A VICVAK L F qlnkdlcv ELGV V ED L VN AL D D SN P L V I A N A T 194
Cdd:COG1413 1 V R RA A A R ALGRLGDPAAVP ---- A L IAA L A D EDPD VR AA A ARALGR L G -------- DPRA V PA L LE AL K D PD P E V R A A A A 68
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 195 A AL IE I H nm D MD AV DL ss LI Q shvsqfll AL NECTEWA R IIILGT L SE ysakds L EAQDIIDRVTAH L QHVNPA V VL A TI 274
Cdd:COG1413 69 E AL GR I G -- D PE AV PA -- LI A -------- AL KDEDPEV R RAAAEA L GR ------ L GDPAAVPALLEA L KDPDWE V RR A AA 130
....*
gi 6322714 275 KVIV R 279
Cdd:COG1413 131 RALG R 135
HEAT
COG1413 HEAT repeat [General function prediction only];
100-200
9.60e-08
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain]
Cd Length: 137
Bit Score: 51.55
E-value: 9.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 100 AV NTFITDAQ DP N P LI R CM A IRTMSM I RVDKILE yiet P L RRT L H D DNAY VR KT A VICVAK L F qlnkdlcv ELGV V ED L V 179
Cdd:COG1413 48 AV PALLEALK DP D P EV R AA A AEALGR I GDPEAVP ---- A L IAA L K D EDPE VR RA A AEALGR L G -------- DPAA V PA L L 115
90 100
....*....|....*....|.
gi 6322714 180 N AL D D SNPL V IAN A TA AL IEI 200
Cdd:COG1413 116 E AL K D PDWE V RRA A AR AL GRL 136
HEAT_2
pfam13646 HEAT repeats; This family includes multiple HEAT repeats.
108-197
5.75e-05
HEAT repeats; This family includes multiple HEAT repeats.
Pssm-ID: 433376 [Multi-domain]
Cd Length: 88
Bit Score: 42.32
E-value: 5.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322714 108 AQ DP N P LI R CM AIR TMSM I RVDKILE yiet P L RRT L H D DNAY VR KT A VICVA K L fqln K D lcve LGVVED L VNA L - DD SN 186
Cdd:pfam13646 9 LR DP D P EV R AA AIR ALGR I GDPEAVP ---- A L LEL L K D EDPA VR RA A AEALG K I ---- G D ---- PEALPA L LEL L r DD DD 76
90
....*....|.
gi 6322714 187 PL V I A N A TA AL 197
Cdd:pfam13646 77 DV V R A A A AE AL 87
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
