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Conserved domains on  [gi|6322804|ref|NP_012877|]
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Anr2p [Saccharomyces cerevisiae S288C]

Protein Classification

DENND11 family protein( domain architecture ID 12102159)

DENND11 family protein is a DUF2347 domain-containing protein; similar to Homo sapiens protein LCHN, a probable guanine nucleotide exchange factor (GEF) that may promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENND11 pfam09804
DENN domain-containing protein 11; DENN domain-containing protein 11 (also known as LCHN) is ...
 33-335 8.15e-95

DENN domain-containing protein 11; DENN domain-containing protein 11 (also known as LCHN) is thought to play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia.


:

Pssm-ID: 430838  Cd Length: 283  Bit Score: 289.58  E-value: 8.15e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322804     33 IFLSKFDMKKGNIIIWSKSINGaaIDLSNIEFKSLPAGIHEQTDDVVNFVvpkeldvcQTAKtttydYGIAYFKQNSFDI 112
Cdd:pfam09804   1 LFLIQFDVKKGYTIVWSKSLPD--VDLEGVEFKSLPSGIHEVSEDLVYFV--------HEDY-----YGLSAFRQNPVDE 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322804    113 IENDNridrskVQMFSLGVIIDVQNassdskkhfykeiYHAYAANRYSSYLESLLGQWIRQRDldKFDIFEKFFDEN--- 189
Cdd:pfam09804  66 EEERG------AKMYSVGVLCDSSN-------------GFIGALWRYAEFLKSLAKHFLESEG--NYSPLEEYFETYkar 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322804    190 ---------------NQGHMAENSVEVFEHSPKERRHLVEYLPYWTRKLGPLIFPLWKASLLQSRILILVPQgeSFELCN 254
Cdd:pfam09804 125 kvtgdqassspdshsRNRSLSDVAVLETPRPPLSPYHPAGSLPELLDKLGPLIFPLYKAALLRKRILFFSSP--PVEPLC 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322804    255 SLAYCVFLISMLPKNLIGNHVSD-EYIKPIFTVSTSDIPFLESFKKGnGYVATTSEEILLYKPEIYDIVVKLTSSSTIEE 333
Cdd:pfam09804 203 SFVYCLSLLSSIPISLEALLPPElSRLRPLFNVGLHDIPFLEKFKKE-GWIACTTDEILESKPELYDVLVDLPPNSSPNA 281


                  ..
gi 6322804    334 SP 335
Cdd:pfam09804 282 KI 283
 
Name Accession Description Interval E-value
DENND11 pfam09804
DENN domain-containing protein 11; DENN domain-containing protein 11 (also known as LCHN) is ...
 33-335 8.15e-95

DENN domain-containing protein 11; DENN domain-containing protein 11 (also known as LCHN) is thought to play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia.


Pssm-ID: 430838  Cd Length: 283  Bit Score: 289.58  E-value: 8.15e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322804     33 IFLSKFDMKKGNIIIWSKSINGaaIDLSNIEFKSLPAGIHEQTDDVVNFVvpkeldvcQTAKtttydYGIAYFKQNSFDI 112
Cdd:pfam09804   1 LFLIQFDVKKGYTIVWSKSLPD--VDLEGVEFKSLPSGIHEVSEDLVYFV--------HEDY-----YGLSAFRQNPVDE 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322804    113 IENDNridrskVQMFSLGVIIDVQNassdskkhfykeiYHAYAANRYSSYLESLLGQWIRQRDldKFDIFEKFFDEN--- 189
Cdd:pfam09804  66 EEERG------AKMYSVGVLCDSSN-------------GFIGALWRYAEFLKSLAKHFLESEG--NYSPLEEYFETYkar 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322804    190 ---------------NQGHMAENSVEVFEHSPKERRHLVEYLPYWTRKLGPLIFPLWKASLLQSRILILVPQgeSFELCN 254
Cdd:pfam09804 125 kvtgdqassspdshsRNRSLSDVAVLETPRPPLSPYHPAGSLPELLDKLGPLIFPLYKAALLRKRILFFSSP--PVEPLC 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322804    255 SLAYCVFLISMLPKNLIGNHVSD-EYIKPIFTVSTSDIPFLESFKKGnGYVATTSEEILLYKPEIYDIVVKLTSSSTIEE 333
Cdd:pfam09804 203 SFVYCLSLLSSIPISLEALLPPElSRLRPLFNVGLHDIPFLEKFKKE-GWIACTTDEILESKPELYDVLVDLPPNSSPNA 281


                  ..
gi 6322804    334 SP 335
Cdd:pfam09804 282 KI 283
 
Name Accession Description Interval E-value
DENND11 pfam09804
DENN domain-containing protein 11; DENN domain-containing protein 11 (also known as LCHN) is ...
 33-335 8.15e-95

DENN domain-containing protein 11; DENN domain-containing protein 11 (also known as LCHN) is thought to play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia.


Pssm-ID: 430838  Cd Length: 283  Bit Score: 289.58  E-value: 8.15e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322804     33 IFLSKFDMKKGNIIIWSKSINGaaIDLSNIEFKSLPAGIHEQTDDVVNFVvpkeldvcQTAKtttydYGIAYFKQNSFDI 112
Cdd:pfam09804   1 LFLIQFDVKKGYTIVWSKSLPD--VDLEGVEFKSLPSGIHEVSEDLVYFV--------HEDY-----YGLSAFRQNPVDE 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322804    113 IENDNridrskVQMFSLGVIIDVQNassdskkhfykeiYHAYAANRYSSYLESLLGQWIRQRDldKFDIFEKFFDEN--- 189
Cdd:pfam09804  66 EEERG------AKMYSVGVLCDSSN-------------GFIGALWRYAEFLKSLAKHFLESEG--NYSPLEEYFETYkar 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322804    190 ---------------NQGHMAENSVEVFEHSPKERRHLVEYLPYWTRKLGPLIFPLWKASLLQSRILILVPQgeSFELCN 254
Cdd:pfam09804 125 kvtgdqassspdshsRNRSLSDVAVLETPRPPLSPYHPAGSLPELLDKLGPLIFPLYKAALLRKRILFFSSP--PVEPLC 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322804    255 SLAYCVFLISMLPKNLIGNHVSD-EYIKPIFTVSTSDIPFLESFKKGnGYVATTSEEILLYKPEIYDIVVKLTSSSTIEE 333
Cdd:pfam09804 203 SFVYCLSLLSSIPISLEALLPPElSRLRPLFNVGLHDIPFLEKFKKE-GWIACTTDEILESKPELYDVLVDLPPNSSPNA 281


                  ..
gi 6322804    334 SP 335
Cdd:pfam09804 282 KI 283
Avl9 pfam09794
Transport protein Avl9; Avl9 is a protein involved in exocytic transport from the Golgi. It ...
 30-273 7.76e-08

Transport protein Avl9; Avl9 is a protein involved in exocytic transport from the Golgi. It has been speculated that Avl9 could play a role in deforming membranes for vesicle fission and/or in recruiting cargo.


Pssm-ID: 430832 [Multi-domain]  Cd Length: 379  Bit Score: 54.59  E-value: 7.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322804     30 IACIFLSKFDMKKGNIIIWSKSINGAAIDL----SNIEFKSLPAGIHEQTDDVVNFVVPKELDVCQTAKTTtydYGIAYF 105
Cdd:pfam09794   1 ILGICVVDFHHKRGPEIEFWYPDLDESSDDpslwKNLPFQALPDGSHSFEEDFSYFTLLYDEPNTGPLTTL---FGISCS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322804    106 KQ-NSFDIIENDNRIDRSKVQMfSLGVIIDVQnassdskkhfykeIYHAYAANryssyLESLLGQWIRQRDLDKFDIFEK 184
Cdd:pfam09794  78 RQiKSSELLKRPADVTRSTVQK-AVVVISRLP-------------IFGQIKDK-----LSIVTNAYFEQGDFSDTSILVS 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322804    185 FFDennqgHMAENSVEVFEHSPKERRHLV-----EYLPYWTRKLgpLIfpLWKASLLQSRILILVPQGESfeLCNSLayc 259
Cdd:pfam09794 139 LYE-----NLNSTFKSLGGEELRESDLYVglslrELVLKFRHNT--LV--LFKALLLEKKVLFYGSPVER--LCNLQ--- 204

                         250
                  ....*....|....
gi 6322804    260 VFLISMLPkNLIGN 273
Cdd:pfam09794 205 FSLISLIP-NLISN 217
SPA pfam08616
Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque ...
 222-332 5.07e-04

Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque of the spindle pole body. In Aspergillus nidulans the protein member is necessary for stabilization of the polarity axes during septation. and in S. cerevisiae it functions as a polarization-specific docking factor.


Pssm-ID: 400783  Cd Length: 113  Bit Score: 39.58  E-value: 5.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322804    222 KLGPLIFPLWKASLLQSRILILVPQGESFELCNS-LAYCVfLISMlpknLIGNHVSDEYIKPIFTVStsdipFLESFKKG 300
Cdd:pfam08616  10 PFTPPIILLINALLTSKRIIFLSYQRSAGEVSEFvLALCN-LISG----GFVLRGFTNNSFPYVDLS-----KLDALRKV 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 6322804    301 NGYVATTSEEILLYKPEIYDIVVKLTSSSTIE 332
Cdd:pfam08616  80 PGYIAGVTNPIFENQDQWWDVLCDLDSGSVKL 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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