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Conserved domains on  [gi|6322847|ref|NP_012920|]
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ribosomal 60S subunit protein L14A [Saccharomyces cerevisiae S288C]

Protein Classification

60S ribosomal protein L14( domain architecture ID 19230365)

eL14 family ribosomal protein contributes to the early assembly of ribosomal subunits

Gene Ontology:  GO:0003735|GO:0042273|GO:0006412|GO:0005840
PubMed:  29788267|24524803

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ribosomal_L14e pfam01929
Ribosomal protein L14; This family includes the eukaryotic ribosomal protein L14.
 55-128 8.91e-34

Ribosomal protein L14; This family includes the eukaryotic ribosomal protein L14.


:

Pssm-ID: 460388  Cd Length: 74  Bit Score: 112.59  E-value: 8.91e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6322847     55 RQAINLGQVVLTPLTFALPRGARTATVSKKWAAAAVCEKWAASSWAKKIAQRERRAALTDFERFQVMVLRKQKR 128
Cdd:pfam01929   1 RQVIPLKRLHLTKFVIKLPRGARTGAVKKAWEKADVDEKWAESAWAKKLAAREKRANLTDFDRFKVMVAKKQRR 74
eL14 cd23702
Vairimorpha necatrix ribosomal protein eL14 and similar proteins; eL14 is a component of the ...
 13-131 8.91e-31

Vairimorpha necatrix ribosomal protein eL14 and similar proteins; eL14 is a component of the large subunit (LSU) of the microsporidian ribosome that reveals a prokaryotic-like rRNA core covered with eukaryotic ribosomal proteins.


:

Pssm-ID: 467915 [Multi-domain]  Cd Length: 82  Bit Score: 105.22  E-value: 8.91e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322847   13 RLVEVGRVVLIKKGQSAGKLAAIVEIIDQKKVLIDGPKAGVPRQAINLGQVVLTPLTFALPrgartatvskkwaaaavce 92
Cdd:cd23702   1 RFVEVGRVVLINYGPDAGKLAVIVDIIDQNRVLVDGPKTGVKRQVVNLKRLSLTDFVVKIP------------------- 61

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 6322847   93 kwaasswakkiaqrerraALTDFERFQVMVLRKQKRYTV 131
Cdd:cd23702  62 ------------------NLTDFDRFKVMLAKKKRRKLV 82
 
Name Accession Description Interval E-value
Ribosomal_L14e pfam01929
Ribosomal protein L14; This family includes the eukaryotic ribosomal protein L14.
 55-128 8.91e-34

Ribosomal protein L14; This family includes the eukaryotic ribosomal protein L14.


Pssm-ID: 460388  Cd Length: 74  Bit Score: 112.59  E-value: 8.91e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6322847     55 RQAINLGQVVLTPLTFALPRGARTATVSKKWAAAAVCEKWAASSWAKKIAQRERRAALTDFERFQVMVLRKQKR 128
Cdd:pfam01929   1 RQVIPLKRLHLTKFVIKLPRGARTGAVKKAWEKADVDEKWAESAWAKKLAAREKRANLTDFDRFKVMVAKKQRR 74
eL14 cd23702
Vairimorpha necatrix ribosomal protein eL14 and similar proteins; eL14 is a component of the ...
 13-131 8.91e-31

Vairimorpha necatrix ribosomal protein eL14 and similar proteins; eL14 is a component of the large subunit (LSU) of the microsporidian ribosome that reveals a prokaryotic-like rRNA core covered with eukaryotic ribosomal proteins.


Pssm-ID: 467915 [Multi-domain]  Cd Length: 82  Bit Score: 105.22  E-value: 8.91e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322847   13 RLVEVGRVVLIKKGQSAGKLAAIVEIIDQKKVLIDGPKAGVPRQAINLGQVVLTPLTFALPrgartatvskkwaaaavce 92
Cdd:cd23702   1 RFVEVGRVVLINYGPDAGKLAVIVDIIDQNRVLVDGPKTGVKRQVVNLKRLSLTDFVVKIP------------------- 61

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 6322847   93 kwaasswakkiaqrerraALTDFERFQVMVLRKQKRYTV 131
Cdd:cd23702  62 ------------------NLTDFDRFKVMLAKKKRRKLV 82
PTZ00065 PTZ00065
60S ribosomal protein L14; Provisional
 13-136 1.68e-30

60S ribosomal protein L14; Provisional


Pssm-ID: 240252 [Multi-domain]  Cd Length: 130  Bit Score: 106.38  E-value: 1.68e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322847    13 RLVEVGRVVLIKKGQSAGKLAAIVEIIDQKKVLIDGPK-AGVPRQAINLGQVVLTPLTFALPRGARTATVSKKWAAAAVC 91
Cdd:PTZ00065   6 RFVEPGRLCLIQYGPDAGKLCFIVDIVTPTRVLVDGAFiTGVKRQSIPLKRLKLTDEKIKINRGARTGTLKKALKKDNAL 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 6322847    92 EKWAASSWAKKIAQRERRAALTDFERFQVMVLRKQKRYTVKKALA 136
Cdd:PTZ00065  86 EEFNKTSLGKKLIIKEKRANMTDFERFKLMVAKKERRKLMKSLKK 130
PRK04333 PRK04333
50S ribosomal protein L14e; Validated
 15-92 6.37e-12

50S ribosomal protein L14e; Validated


Pssm-ID: 235283  Cd Length: 84  Bit Score: 57.38  E-value: 6.37e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6322847    15 VEVGRVVLIKKGQSAGKLAAIVEIIDQKKVLIDGPKA-GVPRQAINLGQVVLTPLTFALPRGARTATVSKKWAAAAVCE 92
Cdd:PRK04333   4 IEVGRVCVKTAGREAGRKCVIVDIIDKNFVLVTGPSLtGVKRRRCNIKHLEPTDKKVDIEKGASDEEVKKALEAAGLTE 82
RPL14A COG2163
Ribosomal protein L14E/L6E/L27E [Translation, ribosomal structure and biogenesis]; Ribosomal ...
 16-50 1.52e-04

Ribosomal protein L14E/L6E/L27E [Translation, ribosomal structure and biogenesis]; Ribosomal protein L14E/L6E/L27E is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 441766  Cd Length: 88  Bit Score: 38.23  E-value: 1.52e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 6322847   16 EVGRVVLIKKGQSAGKLAAIVEIIDQKKVLIDGPK 50
Cdd:COG2163   4 EIGQVVRSKAGRDAGRYFVVVDIIDDNFVLVADGD 38
 
Name Accession Description Interval E-value
Ribosomal_L14e pfam01929
Ribosomal protein L14; This family includes the eukaryotic ribosomal protein L14.
 55-128 8.91e-34

Ribosomal protein L14; This family includes the eukaryotic ribosomal protein L14.


Pssm-ID: 460388  Cd Length: 74  Bit Score: 112.59  E-value: 8.91e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6322847     55 RQAINLGQVVLTPLTFALPRGARTATVSKKWAAAAVCEKWAASSWAKKIAQRERRAALTDFERFQVMVLRKQKR 128
Cdd:pfam01929   1 RQVIPLKRLHLTKFVIKLPRGARTGAVKKAWEKADVDEKWAESAWAKKLAAREKRANLTDFDRFKVMVAKKQRR 74
eL14 cd23702
Vairimorpha necatrix ribosomal protein eL14 and similar proteins; eL14 is a component of the ...
 13-131 8.91e-31

Vairimorpha necatrix ribosomal protein eL14 and similar proteins; eL14 is a component of the large subunit (LSU) of the microsporidian ribosome that reveals a prokaryotic-like rRNA core covered with eukaryotic ribosomal proteins.


Pssm-ID: 467915 [Multi-domain]  Cd Length: 82  Bit Score: 105.22  E-value: 8.91e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322847   13 RLVEVGRVVLIKKGQSAGKLAAIVEIIDQKKVLIDGPKAGVPRQAINLGQVVLTPLTFALPrgartatvskkwaaaavce 92
Cdd:cd23702   1 RFVEVGRVVLINYGPDAGKLAVIVDIIDQNRVLVDGPKTGVKRQVVNLKRLSLTDFVVKIP------------------- 61

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 6322847   93 kwaasswakkiaqrerraALTDFERFQVMVLRKQKRYTV 131
Cdd:cd23702  62 ------------------NLTDFDRFKVMLAKKKRRKLV 82
PTZ00065 PTZ00065
60S ribosomal protein L14; Provisional
 13-136 1.68e-30

60S ribosomal protein L14; Provisional


Pssm-ID: 240252 [Multi-domain]  Cd Length: 130  Bit Score: 106.38  E-value: 1.68e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322847    13 RLVEVGRVVLIKKGQSAGKLAAIVEIIDQKKVLIDGPK-AGVPRQAINLGQVVLTPLTFALPRGARTATVSKKWAAAAVC 91
Cdd:PTZ00065   6 RFVEPGRLCLIQYGPDAGKLCFIVDIVTPTRVLVDGAFiTGVKRQSIPLKRLKLTDEKIKINRGARTGTLKKALKKDNAL 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 6322847    92 EKWAASSWAKKIAQRERRAALTDFERFQVMVLRKQKRYTVKKALA 136
Cdd:PTZ00065  86 EEFNKTSLGKKLIIKEKRANMTDFERFKLMVAKKERRKLMKSLKK 130
KOW_RPL14 cd06088
KOW motif of Ribosomal Protein L14; RPL14 is a component of the large ribosomal subunit in ...
 15-88 6.17e-22

KOW motif of Ribosomal Protein L14; RPL14 is a component of the large ribosomal subunit in both archaea and eukaryotes with KOW motif at its N terminal. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. Auto-antibodies to RPL14 in humans have been associated with systemic lupus erythematosus . Although RPL14 is well conserved, it is not found in all archaea, and therefore it is presumably not essential.


Pssm-ID: 240512  Cd Length: 76  Bit Score: 82.91  E-value: 6.17e-22
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6322847   15 VEVGRVVLIKKGQSAGKLAAIVEIIDQKKVLIDGPKA-GVPRQAINLGQVVLTPLTFALPRGARTATVSKKWAAA 88
Cdd:cd06088   1 VEIGRVVLSKAGRDKGKLYVIVDIIDENVVLVDGPLRtGVKPKKKNLKHLQLTDFVIDIPRGARTKGVKKANEKL 75
PRK04333 PRK04333
50S ribosomal protein L14e; Validated
 15-92 6.37e-12

50S ribosomal protein L14e; Validated


Pssm-ID: 235283  Cd Length: 84  Bit Score: 57.38  E-value: 6.37e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6322847    15 VEVGRVVLIKKGQSAGKLAAIVEIIDQKKVLIDGPKA-GVPRQAINLGQVVLTPLTFALPRGARTATVSKKWAAAAVCE 92
Cdd:PRK04333   4 IEVGRVCVKTAGREAGRKCVIVDIIDKNFVLVTGPSLtGVKRRRCNIKHLEPTDKKVDIEKGASDEEVKKALEAAGLTE 82
RPL14A COG2163
Ribosomal protein L14E/L6E/L27E [Translation, ribosomal structure and biogenesis]; Ribosomal ...
 16-50 1.52e-04

Ribosomal protein L14E/L6E/L27E [Translation, ribosomal structure and biogenesis]; Ribosomal protein L14E/L6E/L27E is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 441766  Cd Length: 88  Bit Score: 38.23  E-value: 1.52e-04
                        10        20        30
                ....*....|....*....|....*....|....*
gi 6322847   16 EVGRVVLIKKGQSAGKLAAIVEIIDQKKVLIDGPK 50
Cdd:COG2163   4 EIGQVVRSKAGRDAGRYFVVVDIIDDNFVLVADGD 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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