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Conserved domains on  [gi|398365529|ref|NP_013027|]
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Sir1p [Saccharomyces cerevisiae S288C]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sir1 pfam11603
Sir1, ORC-binding domain; This entry represents the ORC-binding domain of Sir1. Sir1 interacts ...
 3-125 1.79e-31

Sir1, ORC-binding domain; This entry represents the ORC-binding domain of Sir1. Sir1 interacts with the BAH domain of the Orc1 subunit of the origin recognition complex (ORC) resulting in the establishment of silent chromatin at HMR and HML in S.cerevisiae. The amino acids from the ORC interaction region of Sir1 are presented on a conserved, convex surface that forms a complementary interface with the Orc1 BAH domain, critical for transcriptional silencing. Proteins containing this domain also include Y' element ATP-dependent helicase protein 1, which catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.


:

Pssm-ID: 431955  Cd Length: 120  Bit Score: 118.49  E-value: 1.79e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365529    3 QINSRLAVIDGWLVDTVKRKPINFRSPEVRLLLPnDDDYKKLSQQNLVDWTRLKKDsNSVLVGVKSMELFKHIKLVLREF 82
Cdd:pfam11603   1 KISDRYTVIDGFLVDTVKKKIIIPNYTEILRFLT-KEEREKLSKLKLVDLNELKLE-NSDLIPCDSKELFEHVTTETKEF 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 398365529   83 FLLEDGRIILKRIRSKlRYKVVKKLTCKCCRLYLPKWGTVYIH 125
Cdd:pfam11603  79 YRTEDGFIIVNSTRTS-KKKIRNAITYRVIPIRLKNKGVKYLY 120
Sir1 pfam11603
Sir1, ORC-binding domain; This entry represents the ORC-binding domain of Sir1. Sir1 interacts ...
 465-585 1.88e-28

Sir1, ORC-binding domain; This entry represents the ORC-binding domain of Sir1. Sir1 interacts with the BAH domain of the Orc1 subunit of the origin recognition complex (ORC) resulting in the establishment of silent chromatin at HMR and HML in S.cerevisiae. The amino acids from the ORC interaction region of Sir1 are presented on a conserved, convex surface that forms a complementary interface with the Orc1 BAH domain, critical for transcriptional silencing. Proteins containing this domain also include Y' element ATP-dependent helicase protein 1, which catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.


:

Pssm-ID: 431955  Cd Length: 120  Bit Score: 110.01  E-value: 1.88e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365529  465 YVSPRFLVADGFLIDLAEEKPINPKDPRLLTLLKDHQRAMIDQMNLVKWNDFKK-YQDPIPLKAKTLFKFCKQIKKKFLR 543
Cdd:pfam11603   1 KISDRYTVIDGFLVDTVKKKIIIPNYTEILRFLTKEEREKLSKLKLVDLNELKLeNSDLIPCDSKELFEHVTTETKEFYR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 398365529  544 GADFKLHTLPTEAnlKYEPERMTVLCSCVPILLDDQTVQYLY 585
Cdd:pfam11603  81 TEDGFIIVNSTRT--SKKKIRNAITYRVIPIRLKNKGVKYLY 120
Sir1 super family cl13110
Sir1, ORC-binding domain; This entry represents the ORC-binding domain of Sir1. Sir1 interacts ...
 157-228 2.41e-03

Sir1, ORC-binding domain; This entry represents the ORC-binding domain of Sir1. Sir1 interacts with the BAH domain of the Orc1 subunit of the origin recognition complex (ORC) resulting in the establishment of silent chromatin at HMR and HML in S.cerevisiae. The amino acids from the ORC interaction region of Sir1 are presented on a conserved, convex surface that forms a complementary interface with the Orc1 BAH domain, critical for transcriptional silencing. Proteins containing this domain also include Y' element ATP-dependent helicase protein 1, which catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.


The actual alignment was detected with superfamily member pfam11603:

Pssm-ID: 431955  Cd Length: 120  Bit Score: 38.37  E-value: 2.41e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398365529  157 NVSHQYIIIEGFLLYLNERRLYRWNDNNLRSQvgLTKW-AHLRKTYNPVSLDILYSLNSNFYFVKDDLLFQLL 228
Cdd:pfam11603   1 KISDRYTVIDGFLVDTVKKKIIIPNYTEILRF--LTKEeREKLSKLKLVDLNELKLENSDLIPCDSKELFEHV 71
 
Name Accession Description Interval E-value
Sir1 pfam11603
Sir1, ORC-binding domain; This entry represents the ORC-binding domain of Sir1. Sir1 interacts ...
 3-125 1.79e-31

Sir1, ORC-binding domain; This entry represents the ORC-binding domain of Sir1. Sir1 interacts with the BAH domain of the Orc1 subunit of the origin recognition complex (ORC) resulting in the establishment of silent chromatin at HMR and HML in S.cerevisiae. The amino acids from the ORC interaction region of Sir1 are presented on a conserved, convex surface that forms a complementary interface with the Orc1 BAH domain, critical for transcriptional silencing. Proteins containing this domain also include Y' element ATP-dependent helicase protein 1, which catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.


Pssm-ID: 431955  Cd Length: 120  Bit Score: 118.49  E-value: 1.79e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365529    3 QINSRLAVIDGWLVDTVKRKPINFRSPEVRLLLPnDDDYKKLSQQNLVDWTRLKKDsNSVLVGVKSMELFKHIKLVLREF 82
Cdd:pfam11603   1 KISDRYTVIDGFLVDTVKKKIIIPNYTEILRFLT-KEEREKLSKLKLVDLNELKLE-NSDLIPCDSKELFEHVTTETKEF 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 398365529   83 FLLEDGRIILKRIRSKlRYKVVKKLTCKCCRLYLPKWGTVYIH 125
Cdd:pfam11603  79 YRTEDGFIIVNSTRTS-KKKIRNAITYRVIPIRLKNKGVKYLY 120
Sir1 pfam11603
Sir1, ORC-binding domain; This entry represents the ORC-binding domain of Sir1. Sir1 interacts ...
 465-585 1.88e-28

Sir1, ORC-binding domain; This entry represents the ORC-binding domain of Sir1. Sir1 interacts with the BAH domain of the Orc1 subunit of the origin recognition complex (ORC) resulting in the establishment of silent chromatin at HMR and HML in S.cerevisiae. The amino acids from the ORC interaction region of Sir1 are presented on a conserved, convex surface that forms a complementary interface with the Orc1 BAH domain, critical for transcriptional silencing. Proteins containing this domain also include Y' element ATP-dependent helicase protein 1, which catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.


Pssm-ID: 431955  Cd Length: 120  Bit Score: 110.01  E-value: 1.88e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365529  465 YVSPRFLVADGFLIDLAEEKPINPKDPRLLTLLKDHQRAMIDQMNLVKWNDFKK-YQDPIPLKAKTLFKFCKQIKKKFLR 543
Cdd:pfam11603   1 KISDRYTVIDGFLVDTVKKKIIIPNYTEILRFLTKEEREKLSKLKLVDLNELKLeNSDLIPCDSKELFEHVTTETKEFYR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 398365529  544 GADFKLHTLPTEAnlKYEPERMTVLCSCVPILLDDQTVQYLY 585
Cdd:pfam11603  81 TEDGFIIVNSTRT--SKKKIRNAITYRVIPIRLKNKGVKYLY 120
Sir1 pfam11603
Sir1, ORC-binding domain; This entry represents the ORC-binding domain of Sir1. Sir1 interacts ...
 157-228 2.41e-03

Sir1, ORC-binding domain; This entry represents the ORC-binding domain of Sir1. Sir1 interacts with the BAH domain of the Orc1 subunit of the origin recognition complex (ORC) resulting in the establishment of silent chromatin at HMR and HML in S.cerevisiae. The amino acids from the ORC interaction region of Sir1 are presented on a conserved, convex surface that forms a complementary interface with the Orc1 BAH domain, critical for transcriptional silencing. Proteins containing this domain also include Y' element ATP-dependent helicase protein 1, which catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.


Pssm-ID: 431955  Cd Length: 120  Bit Score: 38.37  E-value: 2.41e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398365529  157 NVSHQYIIIEGFLLYLNERRLYRWNDNNLRSQvgLTKW-AHLRKTYNPVSLDILYSLNSNFYFVKDDLLFQLL 228
Cdd:pfam11603   1 KISDRYTVIDGFLVDTVKKKIIIPNYTEILRF--LTKEeREKLSKLKLVDLNELKLENSDLIPCDSKELFEHV 71
 
Name Accession Description Interval E-value
Sir1 pfam11603
Sir1, ORC-binding domain; This entry represents the ORC-binding domain of Sir1. Sir1 interacts ...
 3-125 1.79e-31

Sir1, ORC-binding domain; This entry represents the ORC-binding domain of Sir1. Sir1 interacts with the BAH domain of the Orc1 subunit of the origin recognition complex (ORC) resulting in the establishment of silent chromatin at HMR and HML in S.cerevisiae. The amino acids from the ORC interaction region of Sir1 are presented on a conserved, convex surface that forms a complementary interface with the Orc1 BAH domain, critical for transcriptional silencing. Proteins containing this domain also include Y' element ATP-dependent helicase protein 1, which catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.


Pssm-ID: 431955  Cd Length: 120  Bit Score: 118.49  E-value: 1.79e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365529    3 QINSRLAVIDGWLVDTVKRKPINFRSPEVRLLLPnDDDYKKLSQQNLVDWTRLKKDsNSVLVGVKSMELFKHIKLVLREF 82
Cdd:pfam11603   1 KISDRYTVIDGFLVDTVKKKIIIPNYTEILRFLT-KEEREKLSKLKLVDLNELKLE-NSDLIPCDSKELFEHVTTETKEF 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 398365529   83 FLLEDGRIILKRIRSKlRYKVVKKLTCKCCRLYLPKWGTVYIH 125
Cdd:pfam11603  79 YRTEDGFIIVNSTRTS-KKKIRNAITYRVIPIRLKNKGVKYLY 120
Sir1 pfam11603
Sir1, ORC-binding domain; This entry represents the ORC-binding domain of Sir1. Sir1 interacts ...
 465-585 1.88e-28

Sir1, ORC-binding domain; This entry represents the ORC-binding domain of Sir1. Sir1 interacts with the BAH domain of the Orc1 subunit of the origin recognition complex (ORC) resulting in the establishment of silent chromatin at HMR and HML in S.cerevisiae. The amino acids from the ORC interaction region of Sir1 are presented on a conserved, convex surface that forms a complementary interface with the Orc1 BAH domain, critical for transcriptional silencing. Proteins containing this domain also include Y' element ATP-dependent helicase protein 1, which catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.


Pssm-ID: 431955  Cd Length: 120  Bit Score: 110.01  E-value: 1.88e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365529  465 YVSPRFLVADGFLIDLAEEKPINPKDPRLLTLLKDHQRAMIDQMNLVKWNDFKK-YQDPIPLKAKTLFKFCKQIKKKFLR 543
Cdd:pfam11603   1 KISDRYTVIDGFLVDTVKKKIIIPNYTEILRFLTKEEREKLSKLKLVDLNELKLeNSDLIPCDSKELFEHVTTETKEFYR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 398365529  544 GADFKLHTLPTEAnlKYEPERMTVLCSCVPILLDDQTVQYLY 585
Cdd:pfam11603  81 TEDGFIIVNSTRT--SKKKIRNAITYRVIPIRLKNKGVKYLY 120
Sir1 pfam11603
Sir1, ORC-binding domain; This entry represents the ORC-binding domain of Sir1. Sir1 interacts ...
 157-228 2.41e-03

Sir1, ORC-binding domain; This entry represents the ORC-binding domain of Sir1. Sir1 interacts with the BAH domain of the Orc1 subunit of the origin recognition complex (ORC) resulting in the establishment of silent chromatin at HMR and HML in S.cerevisiae. The amino acids from the ORC interaction region of Sir1 are presented on a conserved, convex surface that forms a complementary interface with the Orc1 BAH domain, critical for transcriptional silencing. Proteins containing this domain also include Y' element ATP-dependent helicase protein 1, which catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.


Pssm-ID: 431955  Cd Length: 120  Bit Score: 38.37  E-value: 2.41e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398365529  157 NVSHQYIIIEGFLLYLNERRLYRWNDNNLRSQvgLTKW-AHLRKTYNPVSLDILYSLNSNFYFVKDDLLFQLL 228
Cdd:pfam11603   1 KISDRYTVIDGFLVDTVKKKIIIPNYTEILRF--LTKEeREKLSKLKLVDLNELKLENSDLIPCDSKELFEHV 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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