|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
65-376 |
7.92e-43 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 156.61 E-value: 7.92e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 65 GHRDGVYAIA-----KnygslnKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTqprfhdkkPDlksQNFMLSC 139
Cdd:COG2319 118 GHTGAVRSVAfspdgK------TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS--------PD---GKLLASG 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 140 SDDKTVKLWsinvddysnknssdnDSVTNEegLIRTFDG-ESAFQGIDSHRENSTFATGGA--KIHLWDVNRLKPVSDLS 216
Cdd:COG2319 181 SDDGTVRLW---------------DLATGK--LLRTLTGhTGAVRSVAFSPDGKLLASGSAdgTVRLWDLATGKLLRTLT 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 217 WGADNITSLKFNQNETdILASTGSDNSIVLYDLRTNSPTQKIV-QTMRTNAICWNPMEAFnFVTANEDHNAYYYDMRNlS 295
Cdd:COG2319 244 GHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKL-LASGSDDGTVRLWDLAT-G 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 296 RSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIY--HTKRmqhVFQVKYSMDSKYIISGSDDGNVR 373
Cdd:COG2319 321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLtgHTGA---VTSVAFSPDGRTLASGSADGTVR 397
|
...
gi 6323018 374 LWR 376
Cdd:COG2319 398 LWD 400
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
64-376 |
6.18e-42 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 150.95 E-value: 6.18e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 64 YGHRDGVYAIAKNYGSlNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGlCVTQPrfhdkkpdlkSQNFMLSCSDDK 143
Cdd:cd00200 6 KGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRD-VAASA----------DGTYLASGSSDK 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 144 TVKLWSINvddysnknssdndsvTNEegLIRTFDG-ESAFQGIDSHRENSTFATGGA--KIHLWDVNRLKPVSDLSWGAD 220
Cdd:cd00200 74 TIRLWDLE---------------TGE--CVRTLTGhTSYVSSVAFSPDGRILSSSSRdkTIKVWDVETGKCLTTLRGHTD 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 221 NITSLKFNQNETdILASTGSDNSIVLYDLRTNSPTQKIVQ-TMRTNAICWNPMEAfNFVTANEDHNAYYYDMRNlSRSLN 299
Cdd:cd00200 137 WVNSVAFSPDGT-FVASSSQDGTIKLWDLRTGKCVATLTGhTGEVNSVAFSPDGE-KLLSSSSDGTIKLWDLST-GKCLG 213
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6323018 300 VFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHG-HSREIY-HTKRmqhVFQVKYSMDSKYIISGSDDGNVRLWR 376
Cdd:cd00200 214 TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGeCVQTLSgHTNS---VTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| Sof1 |
pfam04158 |
Sof1-like domain; Sof1 is essential for cell growth and is a component of the nucleolar rRNA ... |
377-461 |
1.09e-40 |
|
Sof1-like domain; Sof1 is essential for cell growth and is a component of the nucleolar rRNA processing machinery.
Pssm-ID: 427753 Cd Length: 87 Bit Score: 140.71 E-value: 1.09e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 377 SKAWERSNVKTTREKNKLEYDEKLKERFRHMPEIKRISRHRHVPQVIKKAQEIKNIELSSIKRREANERRTRKD--MPYI 454
Cdd:pfam04158 1 ANASEKLGVLSPRERAALEYNEALKEKYKHMPEIRRIARHRHVPKAIYKAQKIKREMLEARKRKEENRRKHSKPgsVPRK 80
|
....*..
gi 6323018 455 SERKKQI 461
Cdd:pfam04158 81 PERKKHV 87
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
296-333 |
3.63e-07 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 46.54 E-value: 3.63e-07
10 20 30
....*....|....*....|....*....|....*...
gi 6323018 296 RSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYK 333
Cdd:smart00320 3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
295-332 |
2.05e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 44.26 E-value: 2.05e-06
10 20 30
....*....|....*....|....*....|....*...
gi 6323018 295 SRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIY 332
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
201-332 |
4.44e-05 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 46.23 E-value: 4.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 201 IHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDNSIVLYDLRTNSPtqkiVQTMRTNA-IC--WNPMEA-FN 276
Cdd:PLN00181 557 VQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVS----IGTIKTKAnICcvQFPSESgRS 632
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 6323018 277 FVTANEDHNAYYYDMRNLSRSLNVFKDHVSAVMDVDFSPTgDEIVTGSYDKSIRIY 332
Cdd:PLN00181 633 LAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDS-STLVSSSTDNTLKLW 687
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
65-376 |
7.92e-43 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 156.61 E-value: 7.92e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 65 GHRDGVYAIA-----KnygslnKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTqprfhdkkPDlksQNFMLSC 139
Cdd:COG2319 118 GHTGAVRSVAfspdgK------TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS--------PD---GKLLASG 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 140 SDDKTVKLWsinvddysnknssdnDSVTNEegLIRTFDG-ESAFQGIDSHRENSTFATGGA--KIHLWDVNRLKPVSDLS 216
Cdd:COG2319 181 SDDGTVRLW---------------DLATGK--LLRTLTGhTGAVRSVAFSPDGKLLASGSAdgTVRLWDLATGKLLRTLT 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 217 WGADNITSLKFNQNETdILASTGSDNSIVLYDLRTNSPTQKIV-QTMRTNAICWNPMEAFnFVTANEDHNAYYYDMRNlS 295
Cdd:COG2319 244 GHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKL-LASGSDDGTVRLWDLAT-G 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 296 RSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHSREIY--HTKRmqhVFQVKYSMDSKYIISGSDDGNVR 373
Cdd:COG2319 321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLtgHTGA---VTSVAFSPDGRTLASGSADGTVR 397
|
...
gi 6323018 374 LWR 376
Cdd:COG2319 398 LWD 400
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
64-376 |
6.18e-42 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 150.95 E-value: 6.18e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 64 YGHRDGVYAIAKNYGSlNKLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGlCVTQPrfhdkkpdlkSQNFMLSCSDDK 143
Cdd:cd00200 6 KGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRD-VAASA----------DGTYLASGSSDK 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 144 TVKLWSINvddysnknssdndsvTNEegLIRTFDG-ESAFQGIDSHRENSTFATGGA--KIHLWDVNRLKPVSDLSWGAD 220
Cdd:cd00200 74 TIRLWDLE---------------TGE--CVRTLTGhTSYVSSVAFSPDGRILSSSSRdkTIKVWDVETGKCLTTLRGHTD 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 221 NITSLKFNQNETdILASTGSDNSIVLYDLRTNSPTQKIVQ-TMRTNAICWNPMEAfNFVTANEDHNAYYYDMRNlSRSLN 299
Cdd:cd00200 137 WVNSVAFSPDGT-FVASSSQDGTIKLWDLRTGKCVATLTGhTGEVNSVAFSPDGE-KLLSSSSDGTIKLWDLST-GKCLG 213
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6323018 300 VFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHG-HSREIY-HTKRmqhVFQVKYSMDSKYIISGSDDGNVRLWR 376
Cdd:cd00200 214 TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGeCVQTLSgHTNS---VTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| Sof1 |
pfam04158 |
Sof1-like domain; Sof1 is essential for cell growth and is a component of the nucleolar rRNA ... |
377-461 |
1.09e-40 |
|
Sof1-like domain; Sof1 is essential for cell growth and is a component of the nucleolar rRNA processing machinery.
Pssm-ID: 427753 Cd Length: 87 Bit Score: 140.71 E-value: 1.09e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 377 SKAWERSNVKTTREKNKLEYDEKLKERFRHMPEIKRISRHRHVPQVIKKAQEIKNIELSSIKRREANERRTRKD--MPYI 454
Cdd:pfam04158 1 ANASEKLGVLSPRERAALEYNEALKEKYKHMPEIRRIARHRHVPKAIYKAQKIKREMLEARKRKEENRRKHSKPgsVPRK 80
|
....*..
gi 6323018 455 SERKKQI 461
Cdd:pfam04158 81 PERKKHV 87
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
65-335 |
3.05e-32 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 127.33 E-value: 3.05e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 65 GHRDGVYAIAknY---GSLnkLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTqprfhdkkPDlksQNFMLSCSD 141
Cdd:COG2319 160 GHSGAVTSVA--FspdGKL--LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS--------PD---GKLLASGSA 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 142 DKTVKLWSINvddysnknssdndsvTNEegLIRTFDGESAF-QGIDSHRENSTFATGGA--KIHLWDVNRLKPVSDLSWG 218
Cdd:COG2319 225 DGTVRLWDLA---------------TGK--LLRTLTGHSGSvRSVAFSPDGRLLASGSAdgTVRLWDLATGELLRTLTGH 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 219 ADNITSLKFNQNETdILASTGSDNSIVLYDLRTNSPTQKIV-QTMRTNAICWNPMEAFnFVTANEDHNAYYYDMRNlSRS 297
Cdd:COG2319 288 SGGVNSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKT-LASGSDDGTVRLWDLAT-GEL 364
|
250 260 270
....*....|....*....|....*....|....*...
gi 6323018 298 LNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTN 335
Cdd:COG2319 365 LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
65-251 |
1.92e-19 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 90.36 E-value: 1.92e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 65 GHRDGVYAIAknY---GSLnkLATGSADGVIKYWNMSTREEFVSFKAHYGLVTGLCVTqprfhdkkPDLKsqnFMLSCSD 141
Cdd:COG2319 244 GHSGSVRSVA--FspdGRL--LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS--------PDGK---LLASGSD 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 142 DKTVKLWSINvddysnknssdndsvTNEegLIRTFDGESA-FQGIDSHRENSTFATGGA--KIHLWDVNRLKPVSDLSWG 218
Cdd:COG2319 309 DGTVRLWDLA---------------TGK--LLRTLTGHTGaVRSVAFSPDGKTLASGSDdgTVRLWDLATGELLRTLTGH 371
|
170 180 190
....*....|....*....|....*....|...
gi 6323018 219 ADNITSLKFNQNETdILASTGSDNSIVLYDLRT 251
Cdd:COG2319 372 TGAVTSVAFSPDGR-TLASGSADGTVRLWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
222-381 |
1.88e-15 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 76.60 E-value: 1.88e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 222 ITSLKFNqNETDILASTGSDNSIVLYDLRTNSP-------TQKIVQTMrtnAICWNPMeafnFVTANEDHNAYYYDMRNl 294
Cdd:cd00200 12 VTCVAFS-PDGKLLATGSGDGTIKVWDLETGELlrtlkghTGPVRDVA---ASADGTY----LASGSSDKTIRLWDLET- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 295 SRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTN--------HGHSREIYHtkrmqhvfqVKYSMDSKYIISG 366
Cdd:cd00200 83 GECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVEtgkclttlRGHTDWVNS---------VAFSPDGTFVASS 153
|
170
....*....|....*
gi 6323018 367 SDDGNVRLWRSKAWE 381
Cdd:cd00200 154 SQDGTIKLWDLRTGK 168
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
195-376 |
2.67e-13 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 71.48 E-value: 2.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 195 ATGGAKIHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDNSIVLYDLRTNSPTQKIVQTMRTNAICWNPMEA 274
Cdd:COG2319 12 ASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 275 FnFVTANEDHNAYYYDMRNlSRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGhsREIY----HTKRmqh 350
Cdd:COG2319 92 L-LASASADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG--KLLRtltgHSGA--- 164
|
170 180
....*....|....*....|....*.
gi 6323018 351 VFQVKYSMDSKYIISGSDDGNVRLWR 376
Cdd:COG2319 165 VTSVAFSPDGKLLASGSDDGTVRLWD 190
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
297-378 |
1.92e-12 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 67.75 E-value: 1.92e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 297 SLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYKTNHGHsreiYHTKRMQH---VFQVKYSMDSKYIISGSDDGNVR 373
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE----LLRTLKGHtgpVRDVAASADGTYLASGSSDKTIR 76
|
....*
gi 6323018 374 LWRSK 378
Cdd:cd00200 77 LWDLE 81
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
296-333 |
3.63e-07 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 46.54 E-value: 3.63e-07
10 20 30
....*....|....*....|....*....|....*...
gi 6323018 296 RSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIYK 333
Cdd:smart00320 3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
295-332 |
2.05e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 44.26 E-value: 2.05e-06
10 20 30
....*....|....*....|....*....|....*...
gi 6323018 295 SRSLNVFKDHVSAVMDVDFSPTGDEIVTGSYDKSIRIY 332
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
201-332 |
4.44e-05 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 46.23 E-value: 4.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 201 IHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDNSIVLYDLRTNSPtqkiVQTMRTNA-IC--WNPMEA-FN 276
Cdd:PLN00181 557 VQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVS----IGTIKTKAnICcvQFPSESgRS 632
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 6323018 277 FVTANEDHNAYYYDMRNLSRSLNVFKDHVSAVMDVDFSPTgDEIVTGSYDKSIRIY 332
Cdd:PLN00181 633 LAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDS-STLVSSSTDNTLKLW 687
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
333-375 |
2.91e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 38.45 E-value: 2.91e-04
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 6323018 333 KTNHGHSREIYHtkrmqhvfqVKYSMDSKYIISGSDDGNVRLW 375
Cdd:smart00320 6 KTLKGHTGPVTS---------VAFSPDGKYLASGSDDGTIKLW 39
|
|
| Nsa1_WDR74-like |
cd22850 |
Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 ... |
149-259 |
6.32e-04 |
|
Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi and WDR74 (WD repeat-containing protein 74) from mammals and plants, are homologous essential factors for ribosome assembly. In cooperation with the assembly factor Rix7/NVL2, Nsa1/WDR74 participates in an early cleavage of the pre-rRNA processing pathway. Rix7/NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1/WDR74 from nucleolar pre-60S particles. Nsa1/WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7/NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.
Pssm-ID: 439302 [Multi-domain] Cd Length: 333 Bit Score: 41.85 E-value: 6.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 149 SINVDDYSNKNSSDNDSVTNEEGLIRTfDGESAFQGIDSHRENSTF--ATGGAKIHLWDVNRLKP----VSDLSWGADNI 222
Cdd:cd22850 58 NGEVYVLSPVDGELFELLSSIEGLTRS-KEEDKFVGLHLLRSLGLLtcATKSGLLHIIDLEDSKKdsleVKAPLTLPGFL 136
|
90 100 110
....*....|....*....|....*....|....*..
gi 6323018 223 TSLKFNQNETDILASTGSDNSIVLYDLRTNSPTQKIV 259
Cdd:cd22850 137 SAFRVNPTDEGVFAYGGKENDLKLWDLEKDFLKLKQI 173
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
333-375 |
6.49e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 37.32 E-value: 6.49e-04
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 6323018 333 KTNHGHSREIYHtkrmqhvfqVKYSMDSKYIISGSDDGNVRLW 375
Cdd:pfam00400 5 KTLEGHTGSVTS---------LAFSPDGKLLASGSDDGTVKVW 38
|
|
| CDC55 |
COG5170 |
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]; |
200-401 |
1.36e-03 |
|
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
Pssm-ID: 227498 [Multi-domain] Cd Length: 460 Bit Score: 41.17 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 200 KIHLWDVNR---------LKP--VSDLSwgaDNITSLKFNQNETDILASTGSDNSIVLYDlrtnsptqkivqtMRTNAIC 268
Cdd:COG5170 194 RINLWNLEIidgsfnivdIKPhnMEELT---EVITSAEFHPEMCNVFMYSSSKGEIKLND-------------LRQSALC 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 269 WNPMEAFNFVTANEDHNAyyydmrnlsrslnvFKDHVSAVMDVDFSPTGDEIVTGSYDkSIRIYKTN-----------HG 337
Cdd:COG5170 258 DNSKKLFELTIDGVDVDF--------------FEEIVSSISDFKFSDNGRYILSRDYL-TVKIWDVNmaknpiktipmHC 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 338 HSRE----IYHTKRMQHVFQVKYSMDSKYIISGS----------------DDGNVRLWRSKAWERSNVKTtrEKNKLEYD 397
Cdd:COG5170 323 DLMDelndVYENDAIFDKFEISFSGDDKHVLSGSysnnfgiyptdssgfkDVGHVVNLADGSAEDFKVKC--ETNNVEKK 400
|
....
gi 6323018 398 EKLK 401
Cdd:COG5170 401 DKLK 404
|
|
| PTZ00420 |
PTZ00420 |
coronin; Provisional |
201-300 |
4.14e-03 |
|
coronin; Provisional
Pssm-ID: 240412 [Multi-domain] Cd Length: 568 Bit Score: 39.55 E-value: 4.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323018 201 IHLWDVNRLKPVSDLSWGADNITSLKFNQNETDILASTGSDNSIVLYDLRTNSPTQKIVQ---------TMRTNAICWNP 271
Cdd:PTZ00420 56 IRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESVKEIKdpqcilkghKKKISIIDWNP 135
|
90 100
....*....|....*....|....*....
gi 6323018 272 MEAFNFVTANEDHNAYYYDMRNLSRSLNV 300
Cdd:PTZ00420 136 MNYYIMCSSGFDSFVNIWDIENEKRAFQI 164
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
99-149 |
5.06e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 34.98 E-value: 5.06e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 6323018 99 TREEFVSFKAHYGLVTGLCvtqprFHDkkpdlkSQNFMLSCSDDKTVKLWS 149
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVA-----FSP------DGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
65-96 |
7.58e-03 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 34.21 E-value: 7.58e-03
10 20 30
....*....|....*....|....*....|..
gi 6323018 65 GHRDGVYAIAKNyGSLNKLATGSADGVIKYWN 96
Cdd:smart00320 10 GHTGPVTSVAFS-PDGKYLASGSDDGTIKLWD 40
|
|
| |
