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Conserved domains on  [gi|6323092|ref|NP_013164|]
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25S rRNA (uracil2843-N3)-methyltransferase [Saccharomyces cerevisiae S288C]

Protein Classification

SAM-dependent methyltransferase( domain architecture ID 10568280)

SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Saccharomyces cerevisiae 25S rRNA (uridine(2843)-N(3))-methyltransferase that specifically methylates the N(3) position of uridine 2843 (m3U2843) in 25S rRNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Methyltransf_34 pfam11312
Putative SAM-dependent methyltransferase; This family of largely fungal proteins are likely to ...
 76-362 1.86e-132

Putative SAM-dependent methyltransferase; This family of largely fungal proteins are likely to be a methyltransferase. This was determined through multiple motif screening in yeast.


:

Pssm-ID: 431804  Cd Length: 293  Bit Score: 380.00  E-value: 1.86e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323092     76 EKSPLTEQIQAVKSDLYNRDYNAAFNNDsKRI--AYCCRWSPSRATSYASVFAHFPE---LLKIIRCEIDDKD----SNV 146
Cdd:pfam11312   2 SSDDLKPTLQEVKGALYNRDFAAAFGDD-KEYleAYAARWSPSRALCYASLFAGLEPvehLDGLLASDEEDQQgeatLKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323092    147 LCIGGGAGGELVALASIFTLSRDFSSkfasalkidnevnkkPRNLNIQLVDIADWSTVVEKLTATIKSKWLYGD------ 220
Cdd:pfam11312  81 LCIGGGAGAELVALAALLRELEPASS---------------SPSLSLTLVDIADWSSVVTRLQTALTTPPPLSKyasaaa 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323092    221 -------SEAESFNVNFTHKDCLQMTEPQdikiYQGL-----DLITLLFTTNELFTQKKVESIKFLQRLNENCAPGCHLL 288
Cdd:pfam11312 146 raanaplLPPERLNVTFTQLDVLALSEED----LSSLlgskpDLITLLFTLNELFTESIAKTTKFLLRLTAACPPGSLLL 221

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6323092    289 ILESAGSYSHITINN--KKFPIQFLIDTILVGNRkdkgtTGPWSLVSENDSIWYRMDPKLDYSIPLENMRFFYRLY 362
Cdd:pfam11312 222 VVDSPGSYSEITVGKeeKKYPMQWLLDHTLLGKA-----GGAWEKLVSDDSRWFRLDEGLDYPIKLENMRFQYHLY 292
 
Name Accession Description Interval E-value
Methyltransf_34 pfam11312
Putative SAM-dependent methyltransferase; This family of largely fungal proteins are likely to ...
 76-362 1.86e-132

Putative SAM-dependent methyltransferase; This family of largely fungal proteins are likely to be a methyltransferase. This was determined through multiple motif screening in yeast.


Pssm-ID: 431804  Cd Length: 293  Bit Score: 380.00  E-value: 1.86e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323092     76 EKSPLTEQIQAVKSDLYNRDYNAAFNNDsKRI--AYCCRWSPSRATSYASVFAHFPE---LLKIIRCEIDDKD----SNV 146
Cdd:pfam11312   2 SSDDLKPTLQEVKGALYNRDFAAAFGDD-KEYleAYAARWSPSRALCYASLFAGLEPvehLDGLLASDEEDQQgeatLKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323092    147 LCIGGGAGGELVALASIFTLSRDFSSkfasalkidnevnkkPRNLNIQLVDIADWSTVVEKLTATIKSKWLYGD------ 220
Cdd:pfam11312  81 LCIGGGAGAELVALAALLRELEPASS---------------SPSLSLTLVDIADWSSVVTRLQTALTTPPPLSKyasaaa 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323092    221 -------SEAESFNVNFTHKDCLQMTEPQdikiYQGL-----DLITLLFTTNELFTQKKVESIKFLQRLNENCAPGCHLL 288
Cdd:pfam11312 146 raanaplLPPERLNVTFTQLDVLALSEED----LSSLlgskpDLITLLFTLNELFTESIAKTTKFLLRLTAACPPGSLLL 221

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6323092    289 ILESAGSYSHITINN--KKFPIQFLIDTILVGNRkdkgtTGPWSLVSENDSIWYRMDPKLDYSIPLENMRFFYRLY 362
Cdd:pfam11312 222 VVDSPGSYSEITVGKeeKKYPMQWLLDHTLLGKA-----GGAWEKLVSDDSRWFRLDEGLDYPIKLENMRFQYHLY 292
 
Name Accession Description Interval E-value
Methyltransf_34 pfam11312
Putative SAM-dependent methyltransferase; This family of largely fungal proteins are likely to ...
 76-362 1.86e-132

Putative SAM-dependent methyltransferase; This family of largely fungal proteins are likely to be a methyltransferase. This was determined through multiple motif screening in yeast.


Pssm-ID: 431804  Cd Length: 293  Bit Score: 380.00  E-value: 1.86e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323092     76 EKSPLTEQIQAVKSDLYNRDYNAAFNNDsKRI--AYCCRWSPSRATSYASVFAHFPE---LLKIIRCEIDDKD----SNV 146
Cdd:pfam11312   2 SSDDLKPTLQEVKGALYNRDFAAAFGDD-KEYleAYAARWSPSRALCYASLFAGLEPvehLDGLLASDEEDQQgeatLKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323092    147 LCIGGGAGGELVALASIFTLSRDFSSkfasalkidnevnkkPRNLNIQLVDIADWSTVVEKLTATIKSKWLYGD------ 220
Cdd:pfam11312  81 LCIGGGAGAELVALAALLRELEPASS---------------SPSLSLTLVDIADWSSVVTRLQTALTTPPPLSKyasaaa 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323092    221 -------SEAESFNVNFTHKDCLQMTEPQdikiYQGL-----DLITLLFTTNELFTQKKVESIKFLQRLNENCAPGCHLL 288
Cdd:pfam11312 146 raanaplLPPERLNVTFTQLDVLALSEED----LSSLlgskpDLITLLFTLNELFTESIAKTTKFLLRLTAACPPGSLLL 221

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6323092    289 ILESAGSYSHITINN--KKFPIQFLIDTILVGNRkdkgtTGPWSLVSENDSIWYRMDPKLDYSIPLENMRFFYRLY 362
Cdd:pfam11312 222 VVDSPGSYSEITVGKeeKKYPMQWLLDHTLLGKA-----GGAWEKLVSDDSRWFRLDEGLDYPIKLENMRFQYHLY 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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