|
Name |
Accession |
Description |
Interval |
E-value |
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
24-235 |
1.13e-106 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 319.53 E-value: 1.13e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 24 LDSRLLQAIKNIGFQYPTLIQSHAIPLALQqKRDIIAKAATGSGKTLAYLIPVIETILEYKKTidNGEENGTLGIILVPT 103
Cdd:cd17961 1 LDPRLLKAIAKLGWEKPTLIQSKAIPLALE-GKDILARARTGSGKTAAYALPIIQKILKAKAE--SGEEQGTRALILVPT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 104 RELAQQVYNVLEKLVLYCSKDIRTLNISSDMSDSVLSTLLMDQPEIIVGTPGKLLDLLQTKiNSISLNELKFLVVDEVDL 183
Cdd:cd17961 78 RELAQQVSKVLEQLTAYCRKDVRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESG-SLLLLSTLKYLVIDEADL 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 6323306 184 VLTFGYQDDLNKIGEYLPlkKNLQTFLMSATLNDDIQALKQKFCRSPAILKF 235
Cdd:cd17961 157 VLSYGYEEDLKSLLSYLP--KNYQTFLMSATLSEDVEALKKLVLHNPAILKL 206
|
|
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
16-429 |
2.81e-96 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 300.53 E-value: 2.81e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 16 STTFEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPLALqQKRDIIAKAATGSGKTLAYLIPVIEtileykkTIDNGEENGT 95
Cdd:COG0513 1 MMSFADLGLSPPLLKALAELGYTTPTPIQAQAIPLIL-AGRDVLGQAQTGTGKTAAFLLPLLQ-------RLDPSRPRAP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 96 LGIILVPTRELAQQVYNVLEKLVLYcsKDIRTL------NISSDMSDsvlstlLMDQPEIIVGTPGKLLDLLQTKinSIS 169
Cdd:COG0513 73 QALILAPTRELALQVAEELRKLAKY--LGLRVAtvyggvSIGRQIRA------LKRGVDIVVATPGRLLDLIERG--ALD 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 170 LNELKFLVVDEVDLVLTFGYQDDLNKIGEYLPlkKNLQTFLMSATLNDDIQALKQKFCRSPAILKFNDEeiNKNQNKLLQ 249
Cdd:COG0513 143 LSGVETLVLDEADRMLDMGFIEDIERILKLLP--KERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPE--NATAETIEQ 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 250 YYVKVSEFDKF-LLCYVIFKLNLikGKTLIFVNNIDRGYRLKLVMEQFGIKSCILNSELPVNSRQHIVDQFNKNVYQLLI 328
Cdd:COG0513 219 RYYLVDKRDKLeLLRRLLRDEDP--ERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLV 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 329 ATDdteyikeeddeieeghntenqeekslegependkkpskkkkvqvkkdkeygV-SRGVDFKNVACVLNFDLPTTAKSY 407
Cdd:COG0513 297 ATD---------------------------------------------------VaARGIDIDDVSHVINYDLPEDPEDY 325
|
410 420
....*....|....*....|..
gi 6323306 408 VHRVGRTARGGKTGTAISFVVP 429
Cdd:COG0513 326 VHRIGRTGRAGAEGTAISLVTP 347
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
28-234 |
4.54e-64 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 208.84 E-value: 4.54e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 28 LLQAIKNIGFQYPTLIQSHAIPLALQqKRDIIAKAATGSGKTLAYLIPVIETILEYKKtidnGEENGTLGIILVPTRELA 107
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILS-GRDVIGQAQTGSGKTLAFLLPILEKLLPEPK----KKGRGPQALVLAPTRELA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 108 QQVYNVLEKLVlyCSKDIRTLNISSDMSDSVLSTLLMDQPEIIVGTPGKLLDLLQTKinSISLNELKFLVVDEVDLVLTF 187
Cdd:cd00268 76 MQIAEVARKLG--KGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERG--KLDLSNVKYLVLDEADRMLDM 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 6323306 188 GYQDDLNKIGEYLPlkKNLQTFLMSATLNDDIQALKQKFCRSPAILK 234
Cdd:cd00268 152 GFEEDVEKILSALP--KDRQTLLFSATLPEEVKELAKKFLKNPVRIE 196
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
17-427 |
8.27e-59 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 202.48 E-value: 8.27e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 17 TTFEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPLALQQkRDIIAKAATGSGKTLAYLIPVIETILEYKKTidngeENGTL 96
Cdd:PRK11192 1 TTFSELELDESLLEALQDKGYTRPTAIQAEAIPPALDG-RDVLGSAPTGTGKTAAFLLPALQHLLDFPRR-----KSGPP 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 97 GI-ILVPTRELAQQVYNVLEKLVLYCSKDIRTLN--ISSDMSDSVLSTllmDQpEIIVGTPGKLLDLLqtKINSISLNEL 173
Cdd:PRK11192 75 RIlILTPTRELAMQVADQARELAKHTHLDIATITggVAYMNHAEVFSE---NQ-DIVVATPGRLLQYI--KEENFDCRAV 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 174 KFLVVDEVDLVLTFGYQDDLNKIGEYLPLKKnlQTFLMSATLN-DDIQALKQKFCRSPAilKFNDEEINKNQNKLLQYYV 252
Cdd:PRK11192 149 ETLILDEADRMLDMGFAQDIETIAAETRWRK--QTLLFSATLEgDAVQDFAERLLNDPV--EVEAEPSRRERKKIHQWYY 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 253 KVSEFD-KF-LLCyvifklNLIK----GKTLIFVNNIDRGYRLKLVMEQFGIKSCILNSELPVNSRQHIVDQFNKNVYQL 326
Cdd:PRK11192 225 RADDLEhKTaLLC------HLLKqpevTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNV 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 327 LIATDdteyikeeddeieeghntenqeekslegependkkpskkkkvqvkkdkeygV-SRGVDFKNVACVLNFDLPTTAK 405
Cdd:PRK11192 299 LVATD---------------------------------------------------VaARGIDIDDVSHVINFDMPRSAD 327
|
410 420
....*....|....*....|..
gi 6323306 406 SYVHRVGRTARGGKTGTAISFV 427
Cdd:PRK11192 328 TYLHRIGRTGRAGRKGTAISLV 349
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
17-426 |
1.72e-49 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 178.57 E-value: 1.72e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 17 TTFEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPLALQQKrDIIAKAATGSGKTLAYLIPVIETILEY--KKTIDNGEENG 94
Cdd:PRK01297 87 TRFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGH-DAIGRAQTGTGKTAAFLISIINQLLQTppPKERYMGEPRA 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 95 tlgIILVPTRELAQQVYNVLEKLVLYCSKDIRTLNISSDMsDSVLSTLLMDQPEIIVGTPGKLLDLLQTKinSISLNELK 174
Cdd:PRK01297 166 ---LIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDF-DKQLKQLEARFCDILVATPGRLLDFNQRG--EVHLDMVE 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 175 FLVVDEVDLVLTFGYQDDLNKIGEYLPLKKNLQTFLMSATLNDDIQALKQKFCRSPAILKFNDEeiNKNQNKLLQYYVKV 254
Cdd:PRK01297 240 VMVLDEADRMLDMGFIPQVRQIIRQTPRKEERQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPE--NVASDTVEQHVYAV 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 255 SEFDKFLLCYVIFKLNLIKgKTLIFVNNIDRGYRLKLVMEQFGIKSCILNSELPVNSRQHIVDQFNKNVYQLLIATDDTe 334
Cdd:PRK01297 318 AGSDKYKLLYNLVTQNPWE-RVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVA- 395
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 335 yikeeddeieeghntenqeekslegependkkpskkkkvqvkkdkeygvSRGVDFKNVACVLNFDLPTTAKSYVHRVGRT 414
Cdd:PRK01297 396 -------------------------------------------------GRGIHIDGISHVINFTLPEDPDDYVHRIGRT 426
|
410
....*....|..
gi 6323306 415 ARGGKTGTAISF 426
Cdd:PRK01297 427 GRAGASGVSISF 438
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
28-230 |
4.17e-49 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 169.29 E-value: 4.17e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 28 LLQAIKNIGFQYPTLIQSHAIPLALQQKrDIIAKAATGSGKTLAYLIPVIETILEYKKTIDNgeeNGTLGIILVPTRELA 107
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNK-DVVVEAVTGSGKTLAFLIPVLEILLKRKANLKK---GQVGALIISPTRELA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 108 QQVYNVLEKLVLYCSKDIRTLNISSDMSDSV-LSTLLMDQPEIIVGTPGKLLDLLQTKINSISLNELKFLVVDEVDLVLT 186
Cdd:cd17960 77 TQIYEVLQSFLEHHLPKLKCQLLIGGTNVEEdVKKFKRNGPNILVGTPGRLEELLSRKADKVKVKSLEVLVLDEADRLLD 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 6323306 187 FGYQDDLNKIGEYLPlkKNLQTFLMSATLNDDIQALKQKFCRSP 230
Cdd:cd17960 157 LGFEADLNRILSKLP--KQRRTGLFSATQTDAVEELIKAGLRNP 198
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
28-222 |
1.96e-47 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 164.74 E-value: 1.96e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 28 LLQAIKNIGFQYPTLIQSHAIPLALQQKrDIIAKAATGSGKTLAYLIPVIETILEYKKTIdngeeNGTLGIILVPTRELA 107
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGK-DICASAVTGSGKTAAFLLPILERLLYRPKKK-----AATRVLVLVPTRELA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 108 QQVYNVLEKLVLYCskDIRTLNISSDMSDSVLSTLLMDQPEIIVGTPGKLLDLLqTKINSISLNELKFLVVDEVDLVLTF 187
Cdd:cd17947 75 MQCFSVLQQLAQFT--DITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHL-RNSPSFDLDSIEILVLDEADRMLEE 151
|
170 180 190
....*....|....*....|....*....|....*
gi 6323306 188 GYQDDLNKIGEYLPlkKNLQTFLMSATLNDDIQAL 222
Cdd:cd17947 152 GFADELKEILRLCP--RTRQTMLFSATMTDEVKDL 184
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
28-247 |
7.55e-47 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 164.33 E-value: 7.55e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 28 LLQAIKNIGFQYPTLIQSHAIPLALQQKRDIIAKAATGSGKTLAYLIPVIETILEYKKTIDNGEENGTL-GIILVPTREL 106
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAAIRDGKDVIGAAETGSGKTLAFGIPILERLLSQKSSNGVGGKQKPLrALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 107 AQQVYNVLEKLVLYcsKDIRTLNISSDMSDSVLSTLLMDQPEIIVGTPGKLLDLLQTKiNSI--SLNELKFLVVDEVDLV 184
Cdd:cd17946 81 AVQVKDHLKAIAKY--TNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEG-NEHlaNLKSLRFLVLDEADRM 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6323306 185 LTFGYQDDLNKIGEYLP-----LKKNLQTFLMSATLNDDIQALKQKFCRSPAILKFNDEEINKNQNKL 247
Cdd:cd17946 158 LEKGHFAELEKILELLNkdragKKRKRQTFVFSATLTLDHQLPLKLNSKKKKKKKEKKQKLELLIEKV 225
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
16-429 |
3.58e-46 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 168.83 E-value: 3.58e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 16 STTFEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPLALQQKrDIIAKAATGSGKTLAYLIPVIETIleykktidNGEENGT 95
Cdd:PRK11776 3 MTAFSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGK-DVIAQAKTGSGKTAAFGLGLLQKL--------DVKRFRV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 96 LGIILVPTRELAQQVynvleklvlycSKDIRTL-----NIssdmsdSVLsTL------------LMDQPEIIVGTPGKLL 158
Cdd:PRK11776 74 QALVLCPTRELADQV-----------AKEIRRLarfipNI------KVL-TLcggvpmgpqidsLEHGAHIIVGTPGRIL 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 159 DLLQTkiNSISLNELKFLVVDEVDLVLTFGYQDDLNKIGEYLPlkKNLQTFLMSATLNDDIQALKQKFCRSPAILKFNDE 238
Cdd:PRK11776 136 DHLRK--GTLDLDALNTLVLDEADRMLDMGFQDAIDAIIRQAP--ARRQTLLFSATYPEGIAAISQRFQRDPVEVKVEST 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 239 EINknqNKLLQYYVKVSEFDKFLLcyvifkLNLIKGK-----TLIFVNNIDRGYRLKLVMEQFGIKSCILNSELPVNSRQ 313
Cdd:PRK11776 212 HDL---PAIEQRFYEVSPDERLPA------LQRLLLHhqpesCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRD 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 314 HIVDQF-NKNVyQLLIATDdteyikeeddeieeghntenqeekslegependkkpskkkkvqvkkdkeygV-SRGVDFKN 391
Cdd:PRK11776 283 QVLVRFaNRSC-SVLVATD---------------------------------------------------VaARGLDIKA 310
|
410 420 430
....*....|....*....|....*....|....*...
gi 6323306 392 VACVLNFDLPTTAKSYVHRVGRTARGGKTGTAISFVVP 429
Cdd:PRK11776 311 LEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLVAP 348
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
24-229 |
1.00e-44 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 157.74 E-value: 1.00e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 24 LDSRLLQAIKNIGFQYPTLIQSHAIPLALQQKRDIIAKAATGSGKTLAYLIPVIETILeykKTIDNGEENGTLGIILVPT 103
Cdd:cd17964 1 LDPSLLKALTRMGFETMTPVQQKTLKPILSTGDDVLARAKTGTGKTLAFLLPAIQSLL---NTKPAGRRSGVSALIISPT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 104 RELAQQVYNVLEKLvLYCSKDIRTL------NISSDMSDsvlstLLMDQPEIIVGTPGKLLDLLQTKINSISLNELKFLV 177
Cdd:cd17964 78 RELALQIAAEAKKL-LQGLRKLRVQsavggtSRRAELNR-----LRRGRPDILVATPGRLIDHLENPGVAKAFTDLDYLV 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 6323306 178 VDEVDLVLTFGYQDDLNKIGEYLPLKKNL--QTFLMSATLNDDIQALKQKFCRS 229
Cdd:cd17964 152 LDEADRLLDMGFRPDLEQILRHLPEKNADprQTLLFSATVPDEVQQIARLTLKK 205
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
18-234 |
1.02e-44 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 157.48 E-value: 1.02e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 18 TFEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPLALQqKRDIIAKAATGSGKTLAYLIPVIETILEYKKTIdngeengtLG 97
Cdd:cd17954 1 TFKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQ-GRDIIGLAETGSGKTAAFALPILQALLENPQRF--------FA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 98 IILVPTRELAQQVYNVLEKLVLYCSKDIRTLNISSDMSDSVLStlLMDQPEIIVGTPGKLLDLLQ-TKinSISLNELKFL 176
Cdd:cd17954 72 LVLAPTRELAQQISEQFEALGSSIGLKSAVLVGGMDMMAQAIA--LAKKPHVIVATPGRLVDHLEnTK--GFSLKSLKFL 147
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 6323306 177 VVDEVDLVLTFGYQDDLNKIGEYLPlkKNLQTFLMSATLNDDIQALKQKFCRSPAILK 234
Cdd:cd17954 148 VMDEADRLLNMDFEPEIDKILKVIP--RERTTYLFSATMTTKVAKLQRASLKNPVKIE 203
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
28-233 |
2.75e-44 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 157.10 E-value: 2.75e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 28 LLQAIKNIGFQYPTLIQSHAIPLALQQkRDIIAKAATGSGKTLAYLIPVIETILEYKKTIDNGEENGTLGIILVPTRELA 107
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQN-RDIIGIAETGSGKTAAFLIPLLVYISRLPPLDEETKDDGPYALILAPTRELA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 108 QQVYNVLEKLVLYcsKDIRTLNISSDMSDSVLSTLLMDQPEIIVGTPGKLLDLLQTKInsISLNELKFLVVDEVDLVLTF 187
Cdd:cd17945 80 QQIEEETQKFAKP--LGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRL--LVLNQCTYVVLDEADRMIDM 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6323306 188 GYQDDLNKIGEYLPL------------------KKNLQTFLMSATLNDDIQALKQKFCRSPAIL 233
Cdd:cd17945 156 GFEPQVTKILDAMPVsnkkpdteeaeklaasgkHRYRQTMMFTATMPPAVEKIAKGYLRRPVVV 219
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
41-222 |
6.27e-44 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 153.94 E-value: 6.27e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 41 TLIQSHAIPLALQqKRDIIAKAATGSGKTLAYLIPVIETIleykktidNGEENGTLGIILVPTRELAQQVYNVLEKlvLY 120
Cdd:pfam00270 1 TPIQAEAIPAILE-GRDVLVQAPTGSGKTLAFLLPALEAL--------DKLDNGPQALVLAPTRELAEQIYEELKK--LG 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 121 CSKDIRTLNISSDMSDSVLSTLLmDQPEIIVGTPGKLLDLLQtkiNSISLNELKFLVVDEVDLVLTFGYQDDLNKIGEYL 200
Cdd:pfam00270 70 KGLGLKVASLLGGDSRKEQLEKL-KGPDILVGTPGRLLDLLQ---ERKLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRL 145
|
170 180
....*....|....*....|..
gi 6323306 201 PlkKNLQTFLMSATLNDDIQAL 222
Cdd:pfam00270 146 P--KKRQILLLSATLPRNLEDL 165
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
33-223 |
5.39e-43 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 153.13 E-value: 5.39e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 33 KNIGFQYPTLIQSHAIPLALQqKRDIIAKAATGSGKTLAYLIPVIETILEYKKTIDngEENGTLGIILVPTRELAQQVYN 112
Cdd:cd17949 7 SKMGIEKPTAIQKLAIPVLLQ-GRDVLVRSQTGSGKTLAYLLPIIQRLLSLEPRVD--RSDGTLALVLVPTRELALQIYE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 113 VLEKLVLYCSkdirtlnissdmsdSVLSTLLM----DQPE---------IIVGTPGKLLDLLQTKiNSISLNELKFLVVD 179
Cdd:cd17949 84 VLEKLLKPFH--------------WIVPGYLIggekRKSEkarlrkgvnILIATPGRLLDHLKNT-QSFDVSNLRWLVLD 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 6323306 180 EVDLVLTFGYQDDLNKIGEYL-----------PLKKNLQTFLMSATLNDDIQALK 223
Cdd:cd17949 149 EADRLLDMGFEKDITKILELLddkrskaggekSKPSRRQTVLVSATLTDGVKRLA 203
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
18-226 |
6.20e-43 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 153.41 E-value: 6.20e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 18 TFEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPLALQqKRDIIAKAATGSGKTLAYLIPVIETILEykktiDNGEENGTLG 97
Cdd:cd17967 1 SFEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILA-GRDLMACAQTGSGKTAAFLLPIISKLLE-----DGPPSVGRGR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 98 -------IILVPTRELAQQVYNVLEKLVlYCSKdIRTLNI--SSDMSDSVLStlLMDQPEIIVGTPGKLLDLLQTkiNSI 168
Cdd:cd17967 75 rkaypsaLILAPTRELAIQIYEEARKFS-YRSG-VRSVVVygGADVVHQQLQ--LLRGCDILVATPGRLVDFIER--GRI 148
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 169 SLNELKFLVVDEVDLVLTFGYQDDLNKIGEY--LPLKKNLQTFLMSATLNDDIQALKQKF 226
Cdd:cd17967 149 SLSSIKFLVLDEADRMLDMGFEPQIRKIVEHpdMPPKGERQTLMFSATFPREIQRLAADF 208
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
19-226 |
6.33e-43 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 152.76 E-value: 6.33e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 19 FEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPLALQqKRDIIAKAATGSGKTLAYLIPVIETILEykktidngEENGTLGI 98
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILA-GRDVIGGAKTGSGKTAAFALPILQRLSE--------DPYGIFAL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 99 ILVPTRELAQQV---YNVLEKLVlycskDIRTLNISSDMSDSVLSTLLMDQPEIIVGTPGKLLDLLQTKINSI-SLNELK 174
Cdd:cd17955 72 VLTPTRELAYQIaeqFRALGAPL-----GLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRSSDDTTkVLSRVK 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 6323306 175 FLVVDEVDLVLTFGYQDDLNKIGEYLPLKKnlQTFLMSATLNDDIQALKQKF 226
Cdd:cd17955 147 FLVLDEADRLLTGSFEDDLATILSALPPKR--QTLLFSATLTDALKALKELF 196
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
247-427 |
9.86e-42 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 146.88 E-value: 9.86e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 247 LLQYYVKVSEFDKFLLCYVIFKLNLIKGKTLIFVNNIDRGYRLKLVMEQFGIKSCILNSELPVNSRQHIVDQFNKNVYQL 326
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 327 LIATDdteyikeeddeieeghntenqeekslegependkkpskkkkvqvkkdkeyGVSRGVDFKNVACVLNFDLPTTAKS 406
Cdd:cd18787 81 LVATD--------------------------------------------------VAARGLDIPGVDHVINYDLPRDAED 110
|
170 180
....*....|....*....|.
gi 6323306 407 YVHRVGRTARGGKTGTAISFV 427
Cdd:cd18787 111 YVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
18-215 |
2.58e-40 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 145.53 E-value: 2.58e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 18 TFEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPLALQqKRDIIAKAATGSGKTLAYLIPVIETILEYKKTIdngeenGTLG 97
Cdd:cd17959 2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILD-GRDVVAMARTGSGKTAAFLIPMIEKLKAHSPTV------GARA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 98 IILVPTRELAQQVYNVLEKLVlyCSKDIRTLNI--SSDMSDSVlsTLLMDQPEIIVGTPGKLLDLLQTKinSISLNELKF 175
Cdd:cd17959 75 LILSPTRELALQTLKVTKELG--KFTDLRTALLvgGDSLEEQF--EALASNPDIIIATPGRLLHLLVEM--NLKLSSVEY 148
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 6323306 176 LVVDEVDLVLTFGYQDDLNKIGEYLPlkKNLQTFLMSATL 215
Cdd:cd17959 149 VVFDEADRLFEMGFAEQLHEILSRLP--ENRQTLLFSATL 186
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
8-436 |
1.34e-39 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 149.59 E-value: 1.34e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 8 VEGAYIDDSTTFEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPLALqQKRDIIAKAATGSGKTLAYLIPVIETIleykkti 87
Cdd:PTZ00424 19 IESNYDEIVDSFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPIL-DGYDTIGQAQSGTGKTATFVIAALQLI------- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 88 dNGEENGTLGIILVPTRELAQQVYNVLEKLVLYCSKDIRTLNISSDMSDSVLStlLMDQPEIIVGTPGKLLDLLQTKinS 167
Cdd:PTZ00424 91 -DYDLNACQALILAPTRELAQQIQKVVLALGDYLKVRCHACVGGTVVRDDINK--LKAGVHMVVGTPGRVYDMIDKR--H 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 168 ISLNELKFLVVDEVDLVLTFGYQDDLNKIGEYLPlkKNLQTFLMSATLNDDIQALKQKFCRSPAILKFNDEEINKNQNKl 247
Cdd:PTZ00424 166 LRVDDLKLFILDEADEMLSRGFKGQIYDVFKKLP--PDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIR- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 248 lQYYVKVSEFD-KF-LLCYVIFKLNLIkgKTLIFVNNIDRGYRLKLVMEQFGIKSCILNSELPVNSRQHIVDQFNKNVYQ 325
Cdd:PTZ00424 243 -QFYVAVEKEEwKFdTLCDLYETLTIT--QAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 326 LLIATDDteyikeeddeieeghntenqeekslegependkkpskkkkvqvkkdkeygVSRGVDFKNVACVLNFDLPTTAK 405
Cdd:PTZ00424 320 VLITTDL--------------------------------------------------LARGIDVQQVSLVINYDLPASPE 349
|
410 420 430
....*....|....*....|....*....|....*.
gi 6323306 406 SYVHRVGRTARGGKTGTAISFVVP-----LKEFGKH 436
Cdd:PTZ00424 350 NYIHRIGRSGRFGRKGVAINFVTPddieqLKEIERH 385
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
18-426 |
1.89e-39 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 152.41 E-value: 1.89e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 18 TFEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPLALQqKRDIIAKAATGSGKTLAYLIPVIETILEYKKTIDNGEENgTLG 97
Cdd:PRK04537 10 TFSSFDLHPALLAGLESAGFTRCTPIQALTLPVALP-GGDVAGQAQTGTGKTLAFLVAVMNRLLSRPALADRKPED-PRA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 98 IILVPTRELAQQVYNvlEKLVLYCSKDIRTLNISSDMSDSVLSTLLMDQPEIIVGTPGKLLDLL-QTKInsISLNELKFL 176
Cdd:PRK04537 88 LILAPTRELAIQIHK--DAVKFGADLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVkQHKV--VSLHACEIC 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 177 VVDEVDLVLTFGYQDDLNKIGEYLPLKKNLQTFLMSATLNDDIQALKQKFCRSPAILKFNDEEINKNQNKLLQYYVKVSE 256
Cdd:PRK04537 164 VLDEADRMFDLGFIKDIRFLLRRMPERGTRQTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQRIYFPADEE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 257 FDKFLLCYvifkLNLIKG-KTLIFVNNIDRGYRLKLVMEQFGIKSCILNSELPVNSRQHIVDQFNKNVYQLLIATDDTey 335
Cdd:PRK04537 244 KQTLLLGL----LSRSEGaRTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVA-- 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 336 ikeeddeieeghntenqeekslegependkkpskkkkvqvkkdkeygvSRGVDFKNVACVLNFDLPTTAKSYVHRVGRTA 415
Cdd:PRK04537 318 ------------------------------------------------ARGLHIDGVKYVYNYDLPFDAEDYVHRIGRTA 349
|
410
....*....|.
gi 6323306 416 RGGKTGTAISF 426
Cdd:PRK04537 350 RLGEEGDAISF 360
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
29-222 |
4.32e-39 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 142.11 E-value: 4.32e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 29 LQAIKNIGFQYPTLIQSHAIPLALQqKRDIIAKAATGSGKTLAYLIPVIETILEYKKTidngEENGTLGIILVPTRELAQ 108
Cdd:cd17942 2 LKAIEEMGFTKMTEIQAKSIPPLLE-GRDVLGAAKTGSGKTLAFLIPAIELLYKLKFK----PRNGTGVIIISPTRELAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 109 QVYNVLEKLVLYCSKdirTLNIS-SDMSDSVLSTLLMDQPEIIVGTPGKLLDLLQTKINSISLNeLKFLVVDEVDLVLTF 187
Cdd:cd17942 77 QIYGVAKELLKYHSQ---TFGIViGGANRKAEAEKLGKGVNILVATPGRLLDHLQNTKGFLYKN-LQCLIIDEADRILEI 152
|
170 180 190
....*....|....*....|....*....|....*
gi 6323306 188 GYQDDLNKIGEYLPlkKNLQTFLMSATLNDDIQAL 222
Cdd:cd17942 153 GFEEEMRQIIKLLP--KRRQTMLFSATQTRKVEDL 185
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
14-520 |
1.06e-38 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 150.77 E-value: 1.06e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 14 DDSTTFEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPlALQQKRDIIAKAATGSGKTLAYLIPVIETIleykktidNGEEN 93
Cdd:PRK11634 3 EFETTFADLGLKAPILEALNDLGYEKPSPIQAECIP-HLLNGRDVLGMAQTGSGKTAAFSLPLLHNL--------DPELK 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 94 GTLGIILVPTRELAQQVYNVLEKLvlycSKDIRTLNISS----DMSDSVLSTlLMDQPEIIVGTPGKLLDLLqtKINSIS 169
Cdd:PRK11634 74 APQILVLAPTRELAVQVAEAMTDF----SKHMRGVNVVAlyggQRYDVQLRA-LRQGPQIVVGTPGRLLDHL--KRGTLD 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 170 LNELKFLVVDEVDLVLTFGYQDDLNKIGEYLPlkKNLQTFLMSATLNDDIQALKQKFCRSPAILKFNDE-----EINKN- 243
Cdd:PRK11634 147 LSKLSGLVLDEADEMLRMGFIEDVETIMAQIP--EGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSSvttrpDISQSy 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 244 -------QNKLLQYYVKVSEFDkfllcyvifklnlikgKTLIFVNNIDRGYRLKLVMEQFGIKSCILNSELPVNSRQHIV 316
Cdd:PRK11634 225 wtvwgmrKNEALVRFLEAEDFD----------------AAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 317 DQFNKNVYQLLIATDDTeyikeeddeieeghntenqeekslegependkkpskkkkvqvkkdkeygvSRGVDFKNVACVL 396
Cdd:PRK11634 289 ERLKDGRLDILIATDVA--------------------------------------------------ARGLDVERISLVV 318
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 397 NFDLPTTAKSYVHRVGRTARGGKTGTAISFVvplkefgkhkpsmlqtaKKDERILSRIIKQQSKLGL---ELQPYK-FDQ 472
Cdd:PRK11634 319 NYDIPMDSESYVHRIGRTGRAGRAGRALLFV-----------------ENRERRLLRNIERTMKLTIpevELPNAElLGK 381
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 6323306 473 KQVEAFRYRME--------DGFRAVTQVAIREARVKELKQELLASEKLKRHFEENP 520
Cdd:PRK11634 382 RRLEKFAAKVQqqlessdlDQYRALLAKIQPTAEGEELDLETLAAALLKMAQGERP 437
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
19-230 |
2.13e-38 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 140.53 E-value: 2.13e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 19 FEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPLALQQKrDIIAKAATGSGKTLAYLIPVIETIleykktidngeengtLGI 98
Cdd:cd17938 1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGG-DVLMAAETGSGKTGAFCLPVLQIV---------------VAL 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 99 ILVPTRELAQQVYNVLEKLVLYCSK-DIRTLNISSDMSDSVLSTLLMDQPEIIVGTPGKLLDLLQTkiNSISLNELKFLV 177
Cdd:cd17938 65 ILEPSRELAEQTYNCIENFKKYLDNpKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKT--GKLDLSSVRFFV 142
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 6323306 178 VDEVDLVLTFGYQDDLNKIGEYLPL----KKNLQTFLMSATL-NDDIQALKQKFCRSP 230
Cdd:cd17938 143 LDEADRLLSQGNLETINRIYNRIPKitsdGKRLQVIVCSATLhSFEVKKLADKIMHFP 200
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
28-229 |
2.48e-38 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 140.03 E-value: 2.48e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 28 LLQAIKNIGFQYPTLIQSHAIPLALQqKRDIIAKAATGSGKTLAYLIPVIETILEYKKtidngeENGTLGIILVPTRELA 107
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLH-GRDLLACAPTGSGKTLAFLIPILQKLGKPRK------KKGLRALILAPTRELA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 108 QQVYNVLEKLVLycSKDIRTLNISSDMSDSVLSTLLMDQ-PEIIVGTPGKLLDLLQTkiNSISLNELKFLVVDEVDLVLT 186
Cdd:cd17957 74 SQIYRELLKLSK--GTGLRIVLLSKSLEAKAKDGPKSITkYDILVSTPLRLVFLLKQ--GPIDLSSVEYLVLDEADKLFE 149
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 6323306 187 FGYQDDLNKIGEYLPlKKNLQTFLMSATLNDDIQALkqkfCRS 229
Cdd:cd17957 150 PGFREQTDEILAACT-NPNLQRSLFSATIPSEVEEL----ARS 187
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
32-230 |
6.64e-38 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 138.78 E-value: 6.64e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 32 IKNIGFQYPTLIQSHAIPLALQQKRDIIAKAATGSGKTLAYLIPVIETILEYKKTIdngeengtlGIILVPTRELAQQVY 111
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGR---------VLVLVPTRELAEQWA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 112 NVLEKLVLYCSkDIRTLNISSDMSDSVLSTLLMDQPEIIVGTPGKLLDLLqtKINSISLNELKFLVVDEVDLVLTFGYQD 191
Cdd:smart00487 72 EELKKLGPSLG-LKVVGLYGGDSKREQLRKLESGKTDILVTTPGRLLDLL--ENDKLSLSNVDLVILDEAHRLLDGGFGD 148
|
170 180 190
....*....|....*....|....*....|....*....
gi 6323306 192 DLNKIGEYLPlkKNLQTFLMSATLNDDIQALKQKFCRSP 230
Cdd:smart00487 149 QLEKLLKLLP--KNVQLLLLSATPPEEIENLLELFLNDP 185
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
29-222 |
2.17e-37 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 137.42 E-value: 2.17e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 29 LQAIKNIGFQYPTLIQSHAIPLALQQkRDIIAKAATGSGKTLAYLIPVIETILEYKKTIDNGeengtLG-IILVPTRELA 107
Cdd:cd17941 2 LKGLKEAGFIKMTEIQRDSIPHALQG-RDILGAAKTGSGKTLAFLVPLLEKLYRERWTPEDG-----LGaLIISPTRELA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 108 QQVYNVLEKL----VLYCSKDI--RTLNISSDMsdsvlstllMDQPEIIVGTPGKLLDLLQTKINsISLNELKFLVVDEV 181
Cdd:cd17941 76 MQIFEVLRKVgkyhSFSAGLIIggKDVKEEKER---------INRMNILVCTPGRLLQHMDETPG-FDTSNLQMLVLDEA 145
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 6323306 182 DLVLTFGYQDDLNKIGEYLPLKKnlQTFLMSATLNDDIQAL 222
Cdd:cd17941 146 DRILDMGFKETLDAIVENLPKSR--QTLLFSATQTKSVKDL 184
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
19-230 |
3.11e-37 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 137.04 E-value: 3.11e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 19 FEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPLALQqKRDIIAKAATGSGKTLAYLIPVIETIleykktidNGEENGTLGI 98
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALS-GRDILARAKNGTGKTGAYLIPILEKI--------DPKKDVIQAL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 99 ILVPTRELAQQVYNVLEKLVLYCSKDIRTLNISSDMSDSVLStlLMDQPEIIVGTPGKLLDLLQTKInsISLNELKFLVV 178
Cdd:cd17940 72 ILVPTRELALQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMR--LYQTVHVLVGTPGRILDLAKKGV--ADLSHCKTLVL 147
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 6323306 179 DEVDLVLTFGYQDDLNKIGEYLPlkKNLQTFLMSATLNDDIQALKQKFCRSP 230
Cdd:cd17940 148 DEADKLLSQDFQPIIEKILNFLP--KERQILLFSATFPLTVKNFMDRHMHNP 197
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
17-431 |
3.82e-37 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 145.30 E-value: 3.82e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 17 TTFEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPLALQqKRDIIAKAATGSGKTLAYLIPVIETILEyKKTIDNGEenGTL 96
Cdd:PTZ00110 130 VSFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALS-GRDMIGIAETGSGKTLAFLLPAIVHINA-QPLLRYGD--GPI 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 97 GIILVPTRELAQQVYNvlEKLVLYCSKDIRTLNISSDMSDSVLSTLLMDQPEIIVGTPGKLLDLLQTkiNSISLNELKFL 176
Cdd:PTZ00110 206 VLVLAPTRELAEQIRE--QCNKFGASSKIRNTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFLES--NVTNLRRVTYL 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 177 VVDEVDLVLTFGYQDDLNKIGEylPLKKNLQTFLMSATLNDDIQALKQKFCRSPAIlkfndeEIN------KNQNKLLQY 250
Cdd:PTZ00110 282 VLDEADRMLDMGFEPQIRKIVS--QIRPDRQTLMWSATWPKEVQSLARDLCKEEPV------HVNvgsldlTACHNIKQE 353
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 251 YVKVSEFDKFL-LCYVIFKLNLIKGKTLIFV------NNIDRGYRLKlvmeqfGIKSCILNSELPVNSRQHIVDQFNKNV 323
Cdd:PTZ00110 354 VFVVEEHEKRGkLKMLLQRIMRDGDKILIFVetkkgaDFLTKELRLD------GWPALCIHGDKKQEERTWVLNEFKTGK 427
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 324 YQLLIATDDTeyikeeddeieeghntenqeekslegependkkpskkkkvqvkkdkeygvSRGVDFKNVACVLNFDLPTT 403
Cdd:PTZ00110 428 SPIMIATDVA--------------------------------------------------SRGLDVKDVKYVINFDFPNQ 457
|
410 420
....*....|....*....|....*...
gi 6323306 404 AKSYVHRVGRTARGGKTGTAISFVVPLK 431
Cdd:PTZ00110 458 IEDYVHRIGRTGRAGAKGASYTFLTPDK 485
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
18-467 |
6.79e-35 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 137.25 E-value: 6.79e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 18 TFEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPLALQqKRDIIAKAATGSGKTLAYLIPVIETIleykkTIDNGEENG--- 94
Cdd:PRK10590 2 SFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLE-GRDLMASAQTGTGKTAGFTLPLLQHL-----ITRQPHAKGrrp 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 95 TLGIILVPTRELAQQV-YNVLEKlvlycSK--DIRTLNISSDMSDSVLSTLLMDQPEIIVGTPGKLLDLLQTkiNSISLN 171
Cdd:PRK10590 76 VRALILTPTRELAAQIgENVRDY-----SKylNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQ--NAVKLD 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 172 ELKFLVVDEVDLVLTFGYQDDLNKIGEYLPLKKnlQTFLMSATLNDDIQALKQKFCRSPAILkfndeEINKNQNKLLQYY 251
Cdd:PRK10590 149 QVEILVLDEADRMLDMGFIHDIRRVLAKLPAKR--QNLLFSATFSDDIKALAEKLLHNPLEI-----EVARRNTASEQVT 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 252 VKVSEFDKF----LLCYVIFKLNLikGKTLIFVNNIDRGYRLKLVMEQFGIKSCILNSELPVNSRQHIVDQFNKNVYQLL 327
Cdd:PRK10590 222 QHVHFVDKKrkreLLSQMIGKGNW--QQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 328 IATDDTeyikeeddeieeghntenqeekslegependkkpskkkkvqvkkdkeygvSRGVDFKNVACVLNFDLPTTAKSY 407
Cdd:PRK10590 300 VATDIA--------------------------------------------------ARGLDIEELPHVVNYELPNVPEDY 329
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 408 VHRVGRTARGGKTGTAISFVVplkeFGKHKpsmlqTAKKDERILSRIIKQQSKLGLELQP 467
Cdd:PRK10590 330 VHRIGRTGRAAATGEALSLVC----VDEHK-----LLRDIEKLLKKEIPRIAIPGYEPDP 380
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
17-229 |
1.37e-34 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 131.63 E-value: 1.37e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 17 TTFEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPLALQqKRDIIAKAATGSGKTLAYLIPVIETILeyKKTIDNGEENGT- 95
Cdd:cd18052 43 LTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILA-GRDLMACAQTGSGKTAAFLLPVLTGMM--KEGLTASSFSEVq 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 96 --LGIILVPTRELAQQVYNVLEKLVLYCSkdIRTLNISSDMSDSVLSTLLMDQPEIIVGTPGKLLDLLQTKinSISLNEL 173
Cdd:cd18052 120 epQALIVAPTRELANQIFLEARKFSYGTC--IRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFIGRG--KISLSKL 195
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 6323306 174 KFLVVDEVDLVLTFGYQDDLNKIGEYL--PLKKNLQTFLMSATLNDDIQALKQKFCRS 229
Cdd:cd18052 196 KYLILDEADRMLDMGFGPEIRKLVSEPgmPSKEDRQTLMFSATFPEEIQRLAAEFLKE 253
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
24-230 |
5.28e-34 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 128.21 E-value: 5.28e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 24 LDSRLLQAIKNIGFQYPTLIQSHAIpLALQQKRDIIAKAATGSGKTLAYLIPVIETIleykktidNGEENGTLGIILVPT 103
Cdd:cd17939 4 LSEDLLRGIYAYGFEKPSAIQQRAI-VPIIKGRDVIAQAQSGTGKTATFSIGALQRI--------DTTVRETQALVLAPT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 104 RELAQQVYNVLEKLVLYCSkdIRTLNISSDMSDSVLSTLLMDQPEIIVGTPGKLLDLLQtkINSISLNELKFLVVDEVDL 183
Cdd:cd17939 75 RELAQQIQKVVKALGDYMG--VKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQ--RRSLRTDKIKMFVLDEADE 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 6323306 184 VLTFGYQDDLNKIGEYLPlkKNLQTFLMSATLNDDIQALKQKFCRSP 230
Cdd:cd17939 151 MLSRGFKDQIYDIFQFLP--PETQVVLFSATMPHEVLEVTKKFMRDP 195
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
24-230 |
9.71e-34 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 128.26 E-value: 9.71e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 24 LDSRLLQAIKNIGFQYPTLIQSHAIPlALQQKRDIIAKAATGSGKTLAYLIPVIETILEYKKTidnGEENGTLGIILVPT 103
Cdd:cd17953 19 LSEKVLDLIKKLGYEKPTPIQAQALP-AIMSGRDVIGIAKTGSGKTLAFLLPMFRHIKDQRPV---KPGEGPIGLIMAPT 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 104 RELAQQVYNVLEKLvlycSK--DIRTL------NISSDMSDsvlstlLMDQPEIIVGTPGKLLDLLQTKINSI-SLNELK 174
Cdd:cd17953 95 RELALQIYVECKKF----SKalGLRVVcvyggsGISEQIAE------LKRGAEIVVCTPGRMIDILTANNGRVtNLRRVT 164
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 6323306 175 FLVVDEVDLVLTFGYQDDLNKIgeYLPLKKNLQTFLMSATLNDDIQALKQKFCRSP 230
Cdd:cd17953 165 YVVLDEADRMFDMGFEPQIMKI--VNNIRPDRQTVLFSATFPRKVEALARKVLHKP 218
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
28-224 |
1.43e-33 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 127.75 E-value: 1.43e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 28 LLQAIKNIGFQYPTLIQSHAIPLALQQ--------KRDIIAKAATGSGKTLAYLIPVIETILEYKKTIdngeengTLGII 99
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPSskstppyrPGDLCVSAPTGSGKTLAYVLPIVQALSKRVVPR-------LRALI 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 100 LVPTRELAQQVYNVLEKlvlYCSK-DIRTLNISSDMSDSVLSTLLMDQ--------PEIIVGTPGKLLDLLQTKInSISL 170
Cdd:cd17956 74 VVPTKELVQQVYKVFES---LCKGtGLKVVSLSGQKSFKKEQKLLLVDtsgrylsrVDILVATPGRLVDHLNSTP-GFTL 149
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6323306 171 NELKFLVVDEVDLVLTFGYQDDLNKIGEYL------------------PLKKNLQTFLMSATLNDDIQALKQ 224
Cdd:cd17956 150 KHLRFLVIDEADRLLNQSFQDWLETVMKALgrptapdlgsfgdanlleRSVRPLQKLLFSATLTRDPEKLSS 221
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
24-234 |
1.49e-33 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 126.54 E-value: 1.49e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 24 LDSRLLQAIKNIGFQYPTLIQSHAIPLALQQK-RDIIAKAATGSGKTLAYLIPVIETIleykktidNGEENGTLGIILVP 102
Cdd:cd17963 1 LKPELLKGLYAMGFNKPSKIQETALPLILSDPpENLIAQSQSGTGKTAAFVLAMLSRV--------DPTLKSPQALCLAP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 103 TRELAQQVYNVLEKLVLYCskDIRTLNISSDMSDSVlSTLLMDQpeIIVGTPGKLLDLLQTKinSISLNELKFLVVDEVD 182
Cdd:cd17963 73 TRELARQIGEVVEKMGKFT--GVKVALAVPGNDVPR-GKKITAQ--IVIGTPGTVLDWLKKR--QLDLKKIKILVLDEAD 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 6323306 183 LVL-TFGYQDDLNKIGEYLPlkKNLQTFLMSATLNDDIQALKQKFCRSPAILK 234
Cdd:cd17963 146 VMLdTQGHGDQSIRIKRMLP--RNCQILLFSATFPDSVRKFAEKIAPNANTIK 196
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
28-231 |
4.83e-33 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 125.17 E-value: 4.83e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 28 LLQAIKNIGFQYPTLIQSHAIPLALQqKRDIIAKAATGSGKTLAYLIPVIETILEyKKTIDNGEenGTLGIILVPTRELA 107
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALS-GRDMVGIAQTGSGKTLAFLLPAIVHINA-QPPLERGD--GPIVLVLAPTRELA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 108 QQVYNVLEKlvlYC-SKDIRTLNISSDMSDSVLSTLLMDQPEIIVGTPGKLLDLLQtkINSISLNELKFLVVDEVDLVLT 186
Cdd:cd17966 77 QQIQQEANK---FGgSSRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLD--QGKTNLRRVTYLVLDEADRMLD 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 6323306 187 FGYQDDLNKI-GEYLPlkkNLQTFLMSATLNDDIQALKQKFCRSPA 231
Cdd:cd17966 152 MGFEPQIRKIvDQIRP---DRQTLMWSATWPKEVRRLAEDFLKDYI 194
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
28-222 |
6.12e-33 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 125.22 E-value: 6.12e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 28 LLQAIKNIGFQYPTLIQSHAIPLALQqKRDIIAKAATGSGKTLAYLIPVIETILEyKKTIDNGEenGTLGIILVPTRELA 107
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALS-GRDMIGIAKTGSGKTAAFIWPMLVHIMD-QRELEKGE--GPIAVIVAPTRELA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 108 QQVYNVLEKLV-LYcskDIRTLNISSDMSDSVLSTLLMDQPEIIVGTPGKLLDLLQTKinSISLNELKFLVVDEVDLVLT 186
Cdd:cd17952 77 QQIYLEAKKFGkAY---NLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKK--ATNLQRVTYLVLDEADRMFD 151
|
170 180 190
....*....|....*....|....*....|....*.
gi 6323306 187 FGYQDDLNKIGEYlpLKKNLQTFLMSATLNDDIQAL 222
Cdd:cd17952 152 MGFEYQVRSIVGH--VRPDRQTLLFSATFKKKIEQL 185
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
16-230 |
8.75e-33 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 125.15 E-value: 8.75e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 16 STTFEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPLALQQKrDIIAKAATGSGKTLAYLIPVIETIleykktidNGEENGT 95
Cdd:cd17950 1 SSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGM-DVLCQAKSGMGKTAVFVLSTLQQL--------EPVDGQV 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 96 LGIILVPTRELAQQVYNVLEKLVLYCsKDIRT------LNISSDMsdsvlSTLLMDQPEIIVGTPGKLLDLLQTKinSIS 169
Cdd:cd17950 72 SVLVICHTRELAFQISNEYERFSKYM-PNVKTavffggVPIKKDI-----EVLKNKCPHIVVGTPGRILALVREK--KLK 143
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6323306 170 LNELKFLVVDEVDLVL-TFGYQDDLNKIGEYLPLKKnlQTFLMSATLNDDIQALKQKFCRSP 230
Cdd:cd17950 144 LSHVKHFVLDECDKMLeQLDMRRDVQEIFRATPHDK--QVMMFSATLSKEIRPVCKKFMQDP 203
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
28-229 |
5.59e-32 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 122.83 E-value: 5.59e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 28 LLQAIKNIGFQYPTLIQSHAIPLALQqKRDIIAKAATGSGKTLAYLIPVIETIL--EYKKTIDNGEenGTLGIILVPTRE 105
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILS-GRDMIGIAFTGSGKTLVFTLPLIMFALeqEKKLPFIKGE--GPYGLIVCPSRE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 106 LAQQVYNVLEKLVLYCSKD----IRTLNISSDMSDSVLSTLLMDQPEIIVGTPGKLLDLLQTKInsISLNELKFLVVDEV 181
Cdd:cd17951 78 LARQTHEVIEYYCKALQEGgypqLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKK--INLDICRYLCLDEA 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 6323306 182 DLVLTFGYQDDLNKIGEYlpLKKNLQTFLMSATLNDDIqalkQKFCRS 229
Cdd:cd17951 156 DRMIDMGFEEDIRTIFSY--FKGQRQTLLFSATMPKKI----QNFAKS 197
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
17-426 |
1.22e-31 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 127.39 E-value: 1.22e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 17 TTFEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPLALQqKRDIIAKAATGSGKTLAYLIPVIETILEYKKtIDNGEENGTL 96
Cdd:PRK04837 8 QKFSDFALHPQVVEALEKKGFHNCTPIQALALPLTLA-GRDVAGQAQTGTGKTMAFLTATFHYLLSHPA-PEDRKVNQPR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 97 GIILVPTRELAQQVYNVLEKLVLYCSkdIRT-LNISSDMSDSVLSTlLMDQPEIIVGTPGKLLDLlqTKINSISLNELKF 175
Cdd:PRK04837 86 ALIMAPTRELAVQIHADAEPLAQATG--LKLgLAYGGDGYDKQLKV-LESGVDILIGTTGRLIDY--AKQNHINLGAIQV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 176 LVVDEVDLVLTFGYQDDLNKIGEYLPLKKNLQTFLMSATLNDDIQALKQKFCRSPAILKFNDEEINKNQNKLLQYYvkVS 255
Cdd:PRK04837 161 VVLDEADRMFDLGFIKDIRWLFRRMPPANQRLNMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGHRIKEELFY--PS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 256 EFDKFLLCyvifkLNLIK----GKTLIFVNNIDRGYRLKLVMEQFGIKSCILNSELPVNSRQHIVDQFNKNVYQLLIATD 331
Cdd:PRK04837 239 NEEKMRLL-----QTLIEeewpDRAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTRGDLDILVATD 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 332 DTeyikeeddeieeghntenqeekslegependkkpskkkkvqvkkdkeygvSRGVDFKNVACVLNFDLPTTAKSYVHRV 411
Cdd:PRK04837 314 VA--------------------------------------------------ARGLHIPAVTHVFNYDLPDDCEDYVHRI 343
|
410
....*....|....*
gi 6323306 412 GRTARGGKTGTAISF 426
Cdd:PRK04837 344 GRTGRAGASGHSISL 358
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
28-215 |
3.06e-31 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 121.32 E-value: 3.06e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 28 LLQAIKNIGFQYPTLIQSHAIPLALQQKRDIIAkAATGSGKTLAYLIPVIETILEYkKTIDNGEENGTLGIILVPTRELA 107
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCA-AETGSGKTLTYLLPIIQRLLRY-KLLAEGPFNAPRGLVITPSRELA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 108 QQVYNVLEKLVLYCSKDIRTL---NISSDMSDSVlstllMDQPEIIVGTPGKLLDLLQTKInsISLNELKFLVVDEVDLV 184
Cdd:cd17948 79 EQIGSVAQSLTEGLGLKVKVItggRTKRQIRNPH-----FEEVDILVATPGALSKLLTSRI--YSLEQLRHLVLDEADTL 151
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 6323306 185 LTFGYQDDLNKIGEYLPLKKNL-----------QTFLMSATL 215
Cdd:cd17948 152 LDDSFNEKLSHFLRRFPLASRRsentdgldpgtQLVLVSATM 193
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
28-234 |
1.01e-30 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 118.52 E-value: 1.01e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 28 LLQAIKNIGFQYPTLIQSHAIPLALQqKRDIIAKAATGSGKTLAYLIPVIETIleykktidNGEENGTLGIILVPTRELA 107
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLA-GHDLIVQAKSGTGKTLVFVVIALESL--------DLERRHPQVLILAPTREIA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 108 QQVYNVLEKL-----VLYCSKDIRTLNISSDMSDsvlstllMDQPEIIVGTPGKLLDLLqtKINSISLNELKFLVVDEVD 182
Cdd:cd17943 72 VQIHDVFKKIgkkleGLKCEVFIGGTPVKEDKKK-------LKGCHIAVGTPGRIKQLI--ELGALNVSHVRLFVLDEAD 142
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 6323306 183 LVLTFGYQDDLNKIGEYLPLKKnlQTFLMSATLNDDIQALKQKFCRSPAILK 234
Cdd:cd17943 143 KLMEGSFQKDVNWIFSSLPKNK--QVIAFSATYPKNLDNLLARYMRKPVLVR 192
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
28-230 |
1.24e-30 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 118.42 E-value: 1.24e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 28 LLQAIKNIGFQYPTLIQSHAIPLALQQkRDIIAKAATGSGKTLAYLIPVIETILEYKKTidngeengTLGIILVPTRELA 107
Cdd:cd17962 1 LSSNLKKAGYEVPTPIQMQMIPVGLLG-RDILASADTGSGKTAAFLLPVIIRCLTEHRN--------PSALILTPTRELA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 108 QQVYNvLEKLVLYCSKDIRTLNISSDMSDSVLSTLLMDQPEIIVGTPGKLLDLLqtKINSISLNELKFLVVDEVDLVLTF 187
Cdd:cd17962 72 VQIED-QAKELMKGLPPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDIL--KQSSVELDNIKIVVVDEADTMLKM 148
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 6323306 188 GYQDDLNKIGEYLPlkKNLQTFLMSATLNDDIQALKQKFCRSP 230
Cdd:cd17962 149 GFQQQVLDILENIS--HDHQTILVSATIPRGIEQLAGQLLQNP 189
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
28-232 |
1.47e-30 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 118.34 E-value: 1.47e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 28 LLQAIKNIGFQYPTLIQSHAIPLALQqKRDIIAKAATGSGKTLAYLIP-VIETILEykkTIDNGEENGTLGIILVPTREL 106
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQ-GIDLIGVAQTGTGKTLAYLLPgFIHLDLQ---PIPREQRNGPGVLVLTPTREL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 107 AQQVYNVLEKlvlYCSKDIRTLNISSDMSDSVLSTLLMDQPEIIVGTPGKLLDLLQtkINSISLNELKFLVVDEVDLVLT 186
Cdd:cd17958 77 ALQIEAECSK---YSYKGLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQM--NNVINLKSITYLVLDEADRMLD 151
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 6323306 187 FGYQDDLNKIgeYLPLKKNLQTFLMSATLNDDIQALKQKFCRSPAI 232
Cdd:cd17958 152 MGFEPQIRKI--LLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMI 195
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
17-226 |
7.13e-30 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 118.22 E-value: 7.13e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 17 TTFEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPLALQqKRDIIAKAATGSGKTLAYLIPVIETILE---YKKTIDNGEEN 93
Cdd:cd18051 21 ETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKS-KRDLMACAQTGSGKTAAFLLPILSQIYEqgpGESLPSESGYY 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 94 GT-----LGIILVPTRELAQQVYNVLEKL---------VLYCSKDIRTlnissDMSDsvlstlLMDQPEIIVGTPGKLLD 159
Cdd:cd18051 100 GRrkqypLALVLAPTRELASQIYDEARKFayrsrvrpcVVYGGADIGQ-----QMRD------LERGCHLLVATPGRLVD 168
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6323306 160 LLQTkiNSISLNELKFLVVDEVDLVLTFGYQDDLNKIGEY--LPLKKNLQTFLMSATLNDDIQALKQKF 226
Cdd:cd18051 169 MLER--GKIGLDYCKYLVLDEADRMLDMGFEPQIRRIVEQdtMPPTGERQTLMFSATFPKEIQMLARDF 235
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
19-230 |
1.26e-29 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 116.01 E-value: 1.26e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 19 FEAFHLDSRLLQAIKNIGFQYPTLIQSHAIpLALQQKRDIIAKAATGSGKTLAYLIPVIETIleykktidNGEENGTLGI 98
Cdd:cd18046 1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAI-MPCIKGYDVIAQAQSGTGKTATFSISILQQI--------DTSLKATQAL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 99 ILVPTRELAQQVYNVLEKLVLYCSKD----IRTLNISSDMSDsvlstlLMDQPEIIVGTPGKLLDLLQTKInsISLNELK 174
Cdd:cd18046 72 VLAPTRELAQQIQKVVMALGDYMGIKchacIGGTSVRDDAQK------LQAGPHIVVGTPGRVFDMINRRY--LRTDYIK 143
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 6323306 175 FLVVDEVDLVLTFGYQDDLNKIGEYLPlkKNLQTFLMSATLNDDIQALKQKFCRSP 230
Cdd:cd18046 144 MFVLDEADEMLSRGFKDQIYDIFQKLP--PDTQVVLLSATMPNDVLEVTTKFMRDP 197
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
18-427 |
2.03e-29 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 122.20 E-value: 2.03e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 18 TFEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPLALQqKRDIIAKAATGSGKTLAYLIPVIETILEYKktIDNGEEN-GTL 96
Cdd:PLN00206 122 SFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALS-GRSLLVSADTGSGKTASFLVPIISRCCTIR--SGHPSEQrNPL 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 97 GIILVPTRELAQQVYN---VLEKLVLYCSkdirTLNISSD-MSDSVLStlLMDQPEIIVGTPGKLLDLLQTkiNSISLNE 172
Cdd:PLN00206 199 AMVLTPTRELCVQVEDqakVLGKGLPFKT----ALVVGGDaMPQQLYR--IQQGVELIVGTPGRLIDLLSK--HDIELDN 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 173 LKFLVVDEVDLVLTFGYQDDLNKIGEYLPLKknlQTFLMSATLNDDIQALKQKFCRSPAILKFNDEeiNKNQNKLLQYYV 252
Cdd:PLN00206 271 VSVLVLDEVDCMLERGFRDQVMQIFQALSQP---QVLLFSATVSPEVEKFASSLAKDIILISIGNP--NRPNKAVKQLAI 345
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 253 KVSEFDKFLLCYVIFK-LNLIKGKTLIFVNNidrgyRL--KLVMEQF----GIKSCILNSELPVNSRQHIVDQFNKNVYQ 325
Cdd:PLN00206 346 WVETKQKKQKLFDILKsKQHFKPPAVVFVSS-----RLgaDLLANAItvvtGLKALSIHGEKSMKERREVMKSFLVGEVP 420
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 326 LLIATddteyikeeddeieeghntenqeekslegependkkpskkkkvqvkkdkeyGV-SRGVDFKNVACVLNFDLPTTA 404
Cdd:PLN00206 421 VIVAT---------------------------------------------------GVlGRGVDLLRVRQVIIFDMPNTI 449
|
410 420
....*....|....*....|...
gi 6323306 405 KSYVHRVGRTARGGKTGTAISFV 427
Cdd:PLN00206 450 KEYIHQIGRASRMGEKGTAIVFV 472
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
19-230 |
1.91e-28 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 112.56 E-value: 1.91e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 19 FEAFHLDSRLLQAIKNIGFQYPTLIQSHAIpLALQQKRDIIAKAATGSGKTLAYLIPVIETI-LEYKKTidngeengtLG 97
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAI-KPIIKGRDVIAQSQSGTGKTATFSISVLQCLdIQVRET---------QA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 98 IILVPTRELAQQVYNVLEKLVLY----CSKDIRTLNISSDMSDsvlstlLMDQPEIIVGTPGKLLDLLQTKinSISLNEL 173
Cdd:cd18045 71 LILSPTRELAVQIQKVLLALGDYmnvqCHACIGGTSVGDDIRK------LDYGQHIVSGTPGRVFDMIRRR--SLRTRHI 142
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 6323306 174 KFLVVDEVDLVLTFGYQDDLNKIGEYLPLKknLQTFLMSATLNDDIQALKQKFCRSP 230
Cdd:cd18045 143 KMLVLDEADEMLNKGFKEQIYDVYRYLPPA--TQVVLVSATLPQDILEMTNKFMTDP 197
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
19-228 |
6.88e-25 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 103.55 E-value: 6.88e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 19 FEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPLALQQKrDIIAKAATGSGKTLAYLIPVIETIlEYKKTIDNGEenGTLGI 98
Cdd:cd18049 26 FYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGL-DMVGVAQTGSGKTLSYLLPAIVHI-NHQPFLERGD--GPICL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 99 ILVPTRELAQQVYNVLEKLVLYCSkdIRTLNISSDMSDSVLSTLLMDQPEIIVGTPGKLLDLLQTkiNSISLNELKFLVV 178
Cdd:cd18049 102 VLAPTRELAQQVQQVAAEYGRACR--LKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEA--GKTNLRRCTYLVL 177
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 6323306 179 DEVDLVLTFGYQDDLNKIGEylPLKKNLQTFLMSATLNDDIQALKQKFCR 228
Cdd:cd18049 178 DEADRMLDMGFEPQIRKIVD--QIRPDRQTLMWSATWPKEVRQLAEDFLK 225
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
18-240 |
2.17e-24 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 102.02 E-value: 2.17e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 18 TFEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPLALQQ-KRDIIAKAATGSGKTLAYLIPVIETIleykktidNGEENGTL 96
Cdd:cd18048 19 SFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADpPQNLIAQSQSGTGKTAAFVLAMLSRV--------DALKLYPQ 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 97 GIILVPTRELAQQVYNVLEKLVLYCSkDIRtlnissdmsdsVLSTLLMDQP--------EIIVGTPGKLLDLLqTKINSI 168
Cdd:cd18048 91 CLCLSPTFELALQTGKVVEEMGKFCV-GIQ-----------VIYAIRGNRPgkgtdieaQIVIGTPGTVLDWC-FKLRLI 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6323306 169 SLNELKFLVVDEVDLVL-TFGYQDDLNKIGEYLPlkKNLQTFLMSATLNDDIQALKQKFCRSPAILKFNDEEI 240
Cdd:cd18048 158 DVTNISVFVLDEADVMInVQGHSDHSVRVKRSMP--KECQMLLFSATFEDSVWAFAERIVPDPNIIKLKKEEL 228
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
37-228 |
1.49e-23 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 100.47 E-value: 1.49e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 37 FQYPTLIQSHAIPLALQqKRDIIAKAATGSGKTLAYLIPVIETIlEYKKTIDNGEenGTLGIILVPTRELAQQVYNVLEK 116
Cdd:cd18050 82 FKEPTPIQCQGFPLALS-GRDMVGIAQTGSGKTLAYLLPAIVHI-NHQPYLERGD--GPICLVLAPTRELAQQVQQVADD 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 117 LVlYCSKdIRTLNISSDMSDSVLSTLLMDQPEIIVGTPGKLLDLLQTkiNSISLNELKFLVVDEVDLVLTFGYQDDLNKI 196
Cdd:cd18050 158 YG-KSSR-LKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEA--GKTNLRRCTYLVLDEADRMLDMGFEPQIRKI 233
|
170 180 190
....*....|....*....|....*....|..
gi 6323306 197 GEylPLKKNLQTFLMSATLNDDIQALKQKFCR 228
Cdd:cd18050 234 VD--QIRPDRQTLMWSATWPKEVRQLAEDFLR 263
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
40-215 |
3.79e-21 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 93.21 E-value: 3.79e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 40 PTLIQSHAIPLALQQ--------------KRDIIAKAA-TGSGKTLAYLIPVIETI--LEYKKTIDNGEENGTLG----- 97
Cdd:cd17965 31 PSPIQTLAIKKLLKTlmrkvtkqtsneepKLEVFLLAAeTGSGKTLAYLAPLLDYLkrQEQEPFEEAEEEYESAKdtgrp 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 98 --IILVPTRELAQQVYNVLEKLVLYCSKDIRTlnISSDMSDSVLSTLLMDQP--EIIVGTPGKLLDLlqTKINSISLNEL 173
Cdd:cd17965 111 rsVILVPTHELVEQVYSVLKKLSHTVKLGIKT--FSSGFGPSYQRLQLAFKGriDILVTTPGKLASL--AKSRPKILSRV 186
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 6323306 174 KFLVVDEVDLVLTFGYQDDLNKIGEYLPLKKNLqtFLMSATL 215
Cdd:cd17965 187 THLVVDEADTLFDRSFLQDTTSIIKRAPKLKHL--ILCSATI 226
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
18-234 |
6.96e-20 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 88.24 E-value: 6.96e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 18 TFEAFHLDSRLLQAIKNIGFQYPTLIQSHAIPLALQQ-KRDIIAKAATGSGKTLAYLIPVIETILEYKKTidngeengTL 96
Cdd:cd18047 2 SFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEpPQNLIAQSQSGTGKTAAFVLAMLSQVEPANKY--------PQ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 97 GIILVPTRELAQQVYNVLEKLvlycSKDIRTLNISSDMSDSVLSTLLMDQPEIIVGTPGKLLDLLqTKINSISLNELKFL 176
Cdd:cd18047 74 CLCLSPTYELALQTGKVIEQM----GKFYPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDWC-SKLKFIDPKKIKVF 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 6323306 177 VVDEVD-LVLTFGYQDDLNKIGEYLPlkKNLQTFLMSATLNDDIQALKQKFCRSPAILK 234
Cdd:cd18047 149 VLDEADvMIATQGHQDQSIRIQRMLP--RNCQMLLFSATFEDSVWKFAQKVVPDPNVIK 205
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
27-229 |
7.92e-19 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 84.90 E-value: 7.92e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 27 RLLQAiKNIGFQYPtlIQSHAIPLALQQKrDIIAKAATGSGKTLAYLIPVIETILEYKKTIDNGEENGTLgiILVPTREL 106
Cdd:cd17944 3 KLLQA-RGVTYLFP--IQVKTFHPVYSGK-DLIAQARTGTGKTFSFAIPLIEKLQEDQQPRKRGRAPKVL--VLAPTREL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 107 AQQVYNVLeklvlycsKDI-RTLNISSDMSDSVLST---LLMDQPEIIVGTPGKLLDLLQTkiNSISLNELKFLVVDEVD 182
Cdd:cd17944 77 ANQVTKDF--------KDItRKLSVACFYGGTPYQQqifAIRNGIDILVGTPGRIKDHLQN--GRLDLTKLKHVVLDEVD 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 6323306 183 LVLTFGYQDDLNKIgEYLPLKK----NLQTFLMSATLNDDIQALKQKFCRS 229
Cdd:cd17944 147 QMLDMGFAEQVEEI-LSVSYKKdsedNPQTLLFSATCPDWVYNVAKKYMKS 196
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
59-214 |
4.44e-18 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 81.30 E-value: 4.44e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 59 IAKAATGSGKTLAYLIPVIETILEYKKTIdngeengtlgIILVPTRELAQQVYNVLEKLVlycSKDIRTLNISSDMSDSV 138
Cdd:cd00046 5 LITAPTGSGKTLAALLAALLLLLKKGKKV----------LVLVPTKALALQTAERLRELF---GPGIRVAVLVGGSSAEE 71
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6323306 139 LSTLLMDQPEIIVGTPGKLLDLLQtKINSISLNELKFLVVDEVDLVLTFGYQDDLNKIGEYLPLKKNLQTFLMSAT 214
Cdd:cd00046 72 REKNKLGDADIIIATPDMLLNLLL-REDRLFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAGLKNAQVILLSAT 146
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
258-418 |
7.09e-15 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 70.70 E-value: 7.09e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 258 DKFLLCYVIFKLNlIKGKTLIFVNNIDRGYrLKLVMEQFGIKSCILNSELPVNSRQHIVDQFNKNVYQLLIATDDteyik 337
Cdd:pfam00271 1 EKLEALLELLKKE-RGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDV----- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 338 eeddeieeghntenqeekslegependkkpskkkkvqvkkdkeygVSRGVDFKNVACVLNFDLPTTAKSYVHRVGRTARG 417
Cdd:pfam00271 74 ---------------------------------------------AERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRA 108
|
.
gi 6323306 418 G 418
Cdd:pfam00271 109 G 109
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
44-180 |
2.96e-12 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 65.30 E-value: 2.96e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 44 QSHAIpLALQQKRDIIAKAATGSGKTLAYLIPVIETILeykktidngEENGTLGIILVPTRELAQQVYNVLEKLVLYCSK 123
Cdd:cd17923 5 QAEAI-EAARAGRSVVVTTGTASGKSLCYQLPILEALL---------RDPGSRALYLYPTKALAQDQLRSLRELLEQLGL 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 124 DIRTLNISSDMSDSVLSTLLMDQPEIIVGTPgKLLDLLQTKINSI---SLNELKFLVVDE 180
Cdd:cd17923 75 GIRVATYDGDTPREERRAIIRNPPRILLTNP-DMLHYALLPHHDRwarFLRNLRYVVLDE 133
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
288-418 |
7.84e-12 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 61.07 E-value: 7.84e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 288 RLKLVMEQFGIKSCILNSELPVNSRQHIVDQFNKNVYQLLIATDdteyikeeddeieeghntenqeekslegependkkp 367
Cdd:smart00490 2 ELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATD------------------------------------ 45
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 6323306 368 skkkkvqvkkdkeyGVSRGVDFKNVACVLNFDLPTTAKSYVHRVGRTARGG 418
Cdd:smart00490 46 --------------VAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
56-223 |
2.94e-11 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 62.22 E-value: 2.94e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 56 RDIIAKAATGSGKTLAYLIPVIETILEykktidngEENGTLGIILV-PTRELAQQVYNVLEKLVLYCSKDIRTLNISSDM 134
Cdd:cd17922 2 RNVLIAAPTGSGKTEAAFLPALSSLAD--------EPEKGVQVLYIsPLKALINDQERRLEEPLDEIDLEIPVAVRHGDT 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 135 SDSVLSTLLMDQPEIIVGTPGKLLDLLQTKINSISLNELKFLVVDEVDLVLTfgyqddlNKIGEYLPL---------KKN 205
Cdd:cd17922 74 SQSEKAKQLKNPPGILITTPESLELLLVNKKLRELFAGLRYVVVDEIHALLG-------SKRGVQLELllerlrkltGRP 146
|
170
....*....|....*...
gi 6323306 206 LQTFLMSATLNDDIQALK 223
Cdd:cd17922 147 LRRIGLSATLGNLEEAAA 164
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
55-181 |
3.44e-11 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 62.67 E-value: 3.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 55 KRDIIAKAATGSGKTL-AylipvIETILEYKKTIDNGEENGTLGIILVPTRELAQQVYNVLE-----KLVLYCSKDirtl 128
Cdd:cd18034 16 KRNTIVVLPTGSGKTLiA-----VMLIKEMGELNRKEKNPKKRAVFLVPTVPLVAQQAEAIRshtdlKVGEYSGEM---- 86
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 6323306 129 niSSDMSDSVLSTLLMDQPEIIVGTPGKLLDLLQTKInsISLNELKFLVVDEV 181
Cdd:cd18034 87 --GVDKWTKERWKEELEKYDVLVMTAQILLDALRHGF--LSLSDINLLIFDEC 135
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
24-181 |
1.33e-10 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 64.47 E-value: 1.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 24 LDSRLLQAIKNIGFQYPTLIQSHAIPLALQQkRDIIAKAATGSGKTLAYLIPVIETILEykktidngEENGTlGIILVPT 103
Cdd:COG1205 41 LPPELRAALKKRGIERLYSHQAEAIEAARAG-KNVVIATPTASGKSLAYLLPVLEALLE--------DPGAT-ALYLYPT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 104 RELAQQVYNVLEKLVLYCSKDIRTLNISSDMSDSVLSTLLmDQPEIIVGTPgkllDLL-------QTKINSIsLNELKFL 176
Cdd:COG1205 111 KALARDQLRRLRELAEALGLGVRVATYDGDTPPEERRWIR-EHPDIVLTNP----DMLhygllphHTRWARF-FRNLRYV 184
|
....*
gi 6323306 177 VVDEV 181
Cdd:COG1205 185 VIDEA 189
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
28-215 |
1.96e-10 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 63.38 E-value: 1.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 28 LLQAIKNIGFQ--YPTliQSHAIPLALQQKRDIIAKAATGSGKTL-AYLIpvietILeykKTIDNGEengtLGIILVPTR 104
Cdd:COG1204 11 VIEFLKERGIEelYPP--QAEALEAGLLEGKNLVVSAPTASGKTLiAELA-----IL---KALLNGG----KALYIVPLR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 105 ELAQQVYNVLEklvlycsKDIRTLNISSDMS--DSVLSTLLMDQPEIIVGTPGKlLDLLQTKINSIsLNELKFLVVDEVD 182
Cdd:COG1204 77 ALASEKYREFK-------RDFEELGIKVGVStgDYDSDDEWLGRYDILVATPEK-LDSLLRNGPSW-LRDVDLVVVDEAH 147
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 6323306 183 LVltfgyQDD---------LNKIgeyLPLKKNLQTFLMSATL 215
Cdd:COG1204 148 LI-----DDEsrgptlevlLARL---RRLNPEAQIVALSATI 181
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
43-215 |
2.87e-10 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 59.58 E-value: 2.87e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 43 IQSHAIPLALQQKRDIIAKAATGSGKTLAYLIPVIETILEYKKTIdngeengtlgIILVPTRELAQQVYNVLEKLVLYCS 122
Cdd:cd17921 5 IQREALRALYLSGDSVLVSAPTSSGKTLIAELAILRALATSGGKA----------VYIAPTRALVNQKEADLRERFGPLG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 123 KDIRTLnissdMSDSVLSTLLMDQPEIIVGTPGKlLDLLQTKINSISLNELKFLVVDEVDLVltfG-------YQDDLNK 195
Cdd:cd17921 75 KNVGLL-----TGDPSVNKLLLAEADILVATPEK-LDLLLRNGGERLIQDVRLVVVDEAHLI---GdgergvvLELLLSR 145
|
170 180
....*....|....*....|
gi 6323306 196 IgeyLPLKKNLQTFLMSATL 215
Cdd:cd17921 146 L---LRINKNARFVGLSATL 162
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
53-331 |
3.34e-10 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 62.73 E-value: 3.34e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 53 QQKRDIIAKAATGSGKT-LAYLIpvIETILEYKKTIdngeengtlgiILVPTRELAQQVYNVLEKLVlycsKDIRTLNIS 131
Cdd:COG1061 98 RGGGRGLVVAPTGTGKTvLALAL--AAELLRGKRVL-----------VLVPRRELLEQWAEELRRFL----GDPLAGGGK 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 132 SDmsdsvlstllmDQPEIIVGTpgklldlLQTKINSISLNELK----FLVVDEVDLVLTFGYQddlnKIGEYLPLKKNLQ 207
Cdd:COG1061 161 KD-----------SDAPITVAT-------YQSLARRAHLDELGdrfgLVIIDEAHHAGAPSYR----RILEAFPAAYRLG 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 208 tflMSATLN------------DDI-------QALKQKFCRSPAILKFNDE------EINKNQNKLLQYYVKVSEFDKFLL 262
Cdd:COG1061 219 ---LTATPFrsdgreillflfDGIvyeyslkEAIEDGYLAPPEYYGIRVDltderaEYDALSERLREALAADAERKDKIL 295
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6323306 263 CYVIFKLNLIKgKTLIFVNNIDRGYRLKLVMEQFGIKSCILNSELPVNSRQHIVDQFNKNVYQLLIATD 331
Cdd:COG1061 296 RELLREHPDDR-KTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVD 363
|
|
| Cas3 |
COG1203 |
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; ... |
43-330 |
1.76e-09 |
|
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; CRISPR-Cas type I system-associated endonuclease/helicase Cas3 is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 440816 [Multi-domain] Cd Length: 535 Bit Score: 60.48 E-value: 1.76e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 43 IQSHAIPLALQQKRDIIAKAATGSGKTLAYLIPvietileykkTIDNGEENGTLGIILV-PTRELAQQVYNVLEK----- 116
Cdd:COG1203 135 ALELALEAAEEEPGLFILTAPTGGGKTEAALLF----------ALRLAAKHGGRRIIYAlPFTSIINQTYDRLRDlfged 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 117 LVLYCSK-----DIRTLNISSDMSDSVLSTLLMDQPeIIVGTPGKLLDLLQTKINSislNELKF-------LVVDEVD-- 182
Cdd:COG1203 205 VLLHHSLadldlLEEEEEYESEARWLKLLKELWDAP-VVVTTIDQLFESLFSNRKG---QERRLhnlansvIILDEVQay 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 183 ------LVLTFgyqddLNKIGEYlplkkNLQTFLMSATLNddiQALKQKFCRSPAILKFNDEEINKNQNKLLQYYVKVSE 256
Cdd:COG1203 281 ppymlaLLLRL-----LEWLKNL-----GGSVILMTATLP---PLLREELLEAYELIPDEPEELPEYFRAFVRKRVELKE 347
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 257 FDKFL--LCYVIFKLNLIKGKTLIFVNNIDRGYRL--KLVMEQFGIKSCILNSELPVNSRQHIVDQ----FNKNVYQLLI 328
Cdd:COG1203 348 GPLSDeeLAELILEALHKGKSVLVIVNTVKDAQELyeALKEKLPDEEVYLLHSRFCPADRSEIEKEikerLERGKPCILV 427
|
..
gi 6323306 329 AT 330
Cdd:COG1203 428 ST 429
|
|
| DinG |
COG1199 |
Rad3-related DNA helicase DinG [Replication, recombination and repair]; |
51-129 |
1.05e-07 |
|
Rad3-related DNA helicase DinG [Replication, recombination and repair];
Pssm-ID: 440812 [Multi-domain] Cd Length: 629 Bit Score: 54.93 E-value: 1.05e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6323306 51 ALQQKRDIIAKAATGSGKTLAYLIPVIETILEYKKTIdngeengtlgIILVPTRELAQQVYNvleklvlycsKDIRTLN 129
Cdd:COG1199 29 ALAEGRHLLIEAGTGTGKTLAYLVPALLAARETGKKV----------VISTATKALQEQLVE----------KDLPLLR 87
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
44-184 |
1.44e-07 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 51.57 E-value: 1.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 44 QSHAIPLALQQKRDIIAKAATGSGKTLAYLIPVIETILEYKKtidngeengtlGIILVPTRELAQQVYNVLEKLVLYCSK 123
Cdd:cd18028 6 QAEAVRAGLLKGENLLISIPTASGKTLIAEMAMVNTLLEGGK-----------ALYLVPLRALASEKYEEFKKLEEIGLK 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6323306 124 dirtLNISSDMSDSVLSTLlmDQPEIIVGTPGKLLDLLQTKINSIslNELKFLVVDEVDLV 184
Cdd:cd18028 75 ----VGISTGDYDEDDEWL--GDYDIIVATYEKFDSLLRHSPSWL--RDVGVVVVDEIHLI 127
|
|
| DEXHc_cas3 |
cd17930 |
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase ... |
58-215 |
7.22e-06 |
|
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350688 [Multi-domain] Cd Length: 186 Bit Score: 46.90 E-value: 7.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 58 IIAKAATGSGKTLAYLIPvietileykkTIDNGEENGTLGIILV-PTRELAQQVYNVLEK-------------------L 117
Cdd:cd17930 4 VILEAPTGSGKTEAALLW----------ALKLAARGGKRRIIYAlPTRATINQMYERIREilgrlddedkvlllhskaaL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 118 VLYCSKDIRTLNISSDMSDSVLSTLLMDQPeIIVGTPGKLLD-LLQTKINSISLNEL--KFLVVDEV---DLVLTFGYQD 191
Cdd:cd17930 74 ELLESDEEPDDDPVEAVDWALLLKRSWLAP-IVVTTIDQLLEsLLKYKHFERRLHGLanSVVVLDEVqayDPEYMALLLK 152
|
170 180
....*....|....*....|....
gi 6323306 192 DLNKIGEYLplkkNLQTFLMSATL 215
Cdd:cd17930 153 ALLELLGEL----GGPVVLMTATL 172
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
51-234 |
1.17e-05 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 46.37 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 51 ALQQKRDIIAKAATGSGKTLAYLIPVIetileykktIDNGeengtLGIILVPTRELAQ-QVynvlEKLvlyCSKDIRTLN 129
Cdd:cd17920 23 AVLAGRDVLVVMPTGGGKSLCYQLPAL---------LLDG-----VTLVVSPLISLMQdQV----DRL---QQLGIRAAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 130 ISSDMSDS----VLSTLLMDQPEIIVGTPGKLL-DLLQTKINSI-SLNELKFLVVDEVDLVLTFG--YQDDLNKIGEYLP 201
Cdd:cd17920 82 LNSTLSPEekreVLLRIKNGQYKLLYVTPERLLsPDFLELLQRLpERKRLALIVVDEAHCVSQWGhdFRPDYLRLGRLRR 161
|
170 180 190
....*....|....*....|....*....|....*..
gi 6323306 202 LKKNLQTFLMSATLN----DDIqaLKQKFCRSPAILK 234
Cdd:cd17920 162 ALPGVPILALTATATpevrEDI--LKRLGLRNPVIFR 196
|
|
| DEXHc_Brr2_1 |
cd18019 |
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD ... |
36-183 |
2.22e-05 |
|
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350777 [Multi-domain] Cd Length: 214 Bit Score: 45.82 E-value: 2.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 36 GFQYPTLIQSHAIPLALQQKRDIIAKAATGSGKTLAYLIPVIETILEYKKTiDNGEENGTLGIILV-PTRELAQQVynvl 114
Cdd:cd18019 14 GFKSLNRIQSKLFPAAFETDENLLLCAPTGAGKTNVALLTILREIGKHRNP-DGTINLDAFKIVYIaPMKALVQEM---- 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6323306 115 eklVLYCSKDIRTLNIS-SDMS-DSVLSTLLMDQPEIIVGTPGKlLDLLQTKINSISLNEL-KFLVVDEVDL 183
Cdd:cd18019 89 ---VGNFSKRLAPYGITvAELTgDQQLTKEQISETQIIVTTPEK-WDIITRKSGDRTYTQLvRLIIIDEIHL 156
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
65-180 |
2.41e-05 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 45.10 E-value: 2.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 65 GSGKTLAYLIPVIETIleykktidngeENGTLGIILVPTRELAQQVYNVLEKLVlycsKDIRTLNISSDMSDSVLStllm 144
Cdd:cd17918 46 GSGKTLVALGAALLAY-----------KNGKQVAILVPTEILAHQHYEEARKFL----PFINVELVTGGTKAQILS---- 106
|
90 100 110
....*....|....*....|....*....|....*.
gi 6323306 145 dQPEIIVGTpGKLLDLLQTKINsislneLKFLVVDE 180
Cdd:cd17918 107 -GISLLVGT-HALLHLDVKFKN------LDLVIVDE 134
|
|
| DEXHc_RecQ5 |
cd18014 |
DEAH-box helicase domain of RecQ5; ATP-dependent DNA helicase Q5 (RecQ5) is part of the RecQ ... |
29-220 |
1.04e-04 |
|
DEAH-box helicase domain of RecQ5; ATP-dependent DNA helicase Q5 (RecQ5) is part of the RecQ family of highly conserved DNA repair helicases that is part of the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350772 [Multi-domain] Cd Length: 205 Bit Score: 43.61 E-value: 1.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 29 LQAIKNI--GFQYPTLIQSHAIPLALQQKRDIIAKAATGSGKTLAYLIPVIetileykktIDNGeengtLGIILVPTREL 106
Cdd:cd18014 1 RSTLKKVfgHSDFKSPLQEKATMAVVKGNKDVFVCMPTGAGKSLCYQLPAL---------LAKG-----ITIVISPLIAL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 107 AQQVYNVLEKLvlycskDIRTLNISSDMSDSVLSTLLMD------QPEIIVGTP-----GKLLDLLQtkiNSISLNELKF 175
Cdd:cd18014 67 IQDQVDHLKTL------KIRVDSLNSKLSAQERKRIIADlesekpQTKFLYITPemaatSSFQPLLS---SLVSRNLLSY 137
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 6323306 176 LVVDEVDLVLTFGYQ--DDLNKIGEYLPLKKNLQTFLMSATLNDDIQ 220
Cdd:cd18014 138 LVVDEAHCVSQWGHDfrPDYLRLGALRSRYGHVPWVALTATATPQVQ 184
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
44-181 |
1.28e-04 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 45.26 E-value: 1.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 44 QSHAIPLaLQQKRDIIAKAATGSGKTLAYLIPVIETILEYKKTidNGEENGTLGIILVPTRELAQQVY-NVLEKLV---- 118
Cdd:PRK13767 37 QRYAIPL-IHEGKNVLISSPTGSGKTLAAFLAIIDELFRLGRE--GELEDKVYCLYVSPLRALNNDIHrNLEEPLTeire 113
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6323306 119 LYCSKDIRTLNI-----SSDMSDSVLSTLLMDQPEIIVGTPGKLldllqtkinSISLNELKF---------LVVDEV 181
Cdd:PRK13767 114 IAKERGEELPEIrvairTGDTSSYEKQKMLKKPPHILITTPESL---------AILLNSPKFreklrtvkwVIVDEI 181
|
|
| DEXHc_RLR |
cd18036 |
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense ... |
51-181 |
1.37e-04 |
|
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprise RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). RIG-I-like receptors (RLRs) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350794 [Multi-domain] Cd Length: 204 Bit Score: 43.23 E-value: 1.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 51 ALQQKRDIIAkAATGSGKTLAYLIpVIETILEYKKtiDNGEENGTlgIILVPTRELAQQVynvLEKLVLYCSKDIRTLNI 130
Cdd:cd18036 14 ALRGKNTIIC-APTGSGKTRVAVY-ICRHHLEKRR--SAGEKGRV--VVLVNKVPLVEQQ---LEKFFKYFRKGYKVTGL 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 6323306 131 SSDMSDSVLSTLLMDQPEIIVGTPGKLLDLLQ--TKINSISLNELKFLVVDEV 181
Cdd:cd18036 85 SGDSSHKVSFGQIVKASDVIICTPQILINNLLsgREEERVYLSDFSLLIFDEC 137
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
43-184 |
1.45e-04 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 43.11 E-value: 1.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 43 IQSHAIPLALQQKRDIIAKAATGSGKTlaylipvieTILE------YKKTIDNGEENgTLGIILVPTRELAQQVY-NVLE 115
Cdd:cd18023 5 IQSEVFPDLLYSDKNFVVSAPTGSGKT---------VLFElailrlLKERNPLPWGN-RKVVYIAPIKALCSEKYdDWKE 74
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 116 KLVlycSKDIRTLNISSDmsDSVLSTLLMDQPEIIVGTPGKLLDLLQTKINSISLNEL-KFLVVDEVDLV 184
Cdd:cd18023 75 KFG---PLGLSCAELTGD--TEMDDTFEIQDADIILTTPEKWDSMTRRWRDNGNLVQLvALVLIDEVHII 139
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
52-181 |
1.96e-04 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 42.27 E-value: 1.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 52 LQQKRDIIAKAATGSGKTLAYLipviETILEYKKtidNGEENGTLgiILVPTRELAQQVYNVLEKLVLycSKDIRTLNIS 131
Cdd:pfam04851 20 KNGQKRGLIVMATGSGKTLTAA----KLIARLFK---KGPIKKVL--FLVPRKDLLEQALEEFKKFLP--NYVEIGEIIS 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 6323306 132 SDMSDSVLSTLlmdqpEIIVGTPGKLLDLLQTKINSISLNELKFLVVDEV 181
Cdd:pfam04851 89 GDKKDESVDDN-----KIVVTTIQSLYKALELASLELLPDFFDVIIIDEA 133
|
|
| DDXDc_reverse_gyrase |
cd17924 |
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of ... |
33-185 |
2.65e-04 |
|
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350682 [Multi-domain] Cd Length: 189 Bit Score: 42.31 E-value: 2.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 33 KNIGFQYPTLIQSHAIPLALQQKRDIIAkaATGSGKTLAYLIPVIETILEYKKTIdngeengtlgiILVPTRELAQQVYN 112
Cdd:cd17924 12 KKTGFPPWGAQRTWAKRLLRGKSFAIIA--PTGVGKTTFGLATSLYLASKGKRSY-----------LIFPTKSLVKQAYE 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6323306 113 VLEKLVLYCSKDIRTLNISSDMSDS----VLSTLLMDQPEIIVGTPGklldLLQTKINSISLNELKFLVVDEVDLVL 185
Cdd:cd17924 79 RLSKYAEKAGVEVKILVYHSRLKKKekeeLLEKIEKGDFDILVTTNQ----FLSKNFDLLSNKKFDFVFVDDVDAVL 151
|
|
| DEXHc_ASCC3_1 |
cd18020 |
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
43-184 |
6.80e-04 |
|
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350778 [Multi-domain] Cd Length: 199 Bit Score: 41.26 E-value: 6.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323306 43 IQSHAIPLALQQKRDIIAKAATGSGKTLAYLIPVIETILEYKKTIDNGEENGTLGIILVPTRELAQQVYNVLEKLVLYCS 122
Cdd:cd18020 5 IQSLVFPVAYKTNENMLICAPTGAGKTNIAMLTILHEIRQHVNQGGVIKKDDFKIVYIAPMKALAAEMVEKFSKRLAPLG 84
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6323306 123 KDIRTLniSSDMSdsvLSTLLMDQPEIIVGTPGKlLDLLQTKINSIS--LNELKFLVVDEVDLV 184
Cdd:cd18020 85 IKVKEL--TGDMQ---LTKKEIAETQIIVTTPEK-WDVVTRKSSGDValSQLVRLLIIDEVHLL 142
|
|
|