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Conserved domains on  [gi|6323311|ref|NP_013383|]
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Rso55p [Saccharomyces cerevisiae S288C]

Protein Classification

peptide chain release factor family protein( domain architecture ID 10452619)

peptide chain release factor family protein such as mitochondrial translation release factor in rescue (MTRFR) that is part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation

CATH:  3.30.160.20
Gene Ontology:  GO:0003747
PubMed:  1408743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 47-95 1.26e-17

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


:

Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 73.23  E-value: 1.26e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 6323311     47 GPGGQKINKCNSKVQLRHEPTGIVVECQETRSREQNRKLARLKLARELA 95
Cdd:pfam00472  21 GAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLY 69
 
Name Accession Description Interval E-value
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 47-95 1.26e-17

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 73.23  E-value: 1.26e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 6323311     47 GPGGQKINKCNSKVQLRHEPTGIVVECQETRSREQNRKLARLKLARELA 95
Cdd:pfam00472  21 GAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLY 69
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 47-96 4.15e-14

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 65.15  E-value: 4.15e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6323311   47 GPGGQKINKCNSKVQLRHE------------PTGIVVECQETRSREQNRKLARLKLARELAA 96
Cdd:COG1186  37 GAGGQNVNKVSSAVRLTHDiassslpdsrltPGGIVVKAQEERSQHQNREDALKRLKALLYE 98
prfA PRK00591
peptide chain release factor 1; Validated
 47-83 3.38e-11

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 59.71  E-value: 3.38e-11
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 6323311    47 GPGGQKINKCNSKVQLRHEPTGIVVECQETRSREQNR 83
Cdd:PRK00591 232 GAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNK 268
 
Name Accession Description Interval E-value
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 47-95 1.26e-17

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 73.23  E-value: 1.26e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 6323311     47 GPGGQKINKCNSKVQLRHEPTGIVVECQETRSREQNRKLARLKLARELA 95
Cdd:pfam00472  21 GAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLY 69
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 47-96 4.15e-14

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 65.15  E-value: 4.15e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6323311   47 GPGGQKINKCNSKVQLRHE------------PTGIVVECQETRSREQNRKLARLKLARELAA 96
Cdd:COG1186  37 GAGGQNVNKVSSAVRLTHDiassslpdsrltPGGIVVKAQEERSQHQNREDALKRLKALLYE 98
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 47-83 4.35e-12

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 62.33  E-value: 4.35e-12
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 6323311   47 GPGGQKINKCNSKVQLRHEPTGIVVECQETRSREQNR 83
Cdd:COG0216 230 GAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNK 266
prfA PRK00591
peptide chain release factor 1; Validated
 47-83 3.38e-11

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 59.71  E-value: 3.38e-11
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 6323311    47 GPGGQKINKCNSKVQLRHEPTGIVVECQETRSREQNR 83
Cdd:PRK00591 232 GAGGQHVNTTDSAVRITHLPTGIVVECQDERSQHKNK 268
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 47-94 1.51e-09

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 55.05  E-value: 1.51e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 6323311    47 GPGGQKINKCNSKVQLRHEPTGIVVECQETRSREQNRKLARLKLAREL 94
Cdd:PRK08787 187 GAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAMKMLAAKL 234
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 47-94 1.94e-09

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 54.81  E-value: 1.94e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 6323311    47 GPGGQKINKCNSKVQLRHEPTGIVVECQETRSREQNRKLARLKLAREL 94
Cdd:PRK05589 207 GAGGQHVNKTESAVRITHIPTGIVVQCQNERSQHSNKETAMKMLKSKL 254
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 47-86 7.63e-08

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 50.26  E-value: 7.63e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 6323311    47 GPGGQKINKCNSKVQLRHEPTGIVVECQETRSREQNRKLA 86
Cdd:PRK07342 210 GAGGQHVNTTDSAVRITHIPTGIVVQCQQERSQHKNRAKA 249
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 27-94 7.67e-06

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 44.34  E-value: 7.67e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6323311    27 PKFTPEMEAQCTEKFL----HGGRGPGGQKINKCNSKVQLRHEPTGIVVECQETRSREQNRKLARLKLAREL 94
Cdd:PRK06746 184 PEFNDEVEIEVRTEDLkidtYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNREHAMKMLKAKL 255
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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