NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|6323312|ref|NP_013385|]
View 

Put7p [Saccharomyces cerevisiae S288C]

Protein Classification

CCDC90 family protein( domain architecture ID 4402)

coiled-coil domain-containing protein 90 (CCDC90) family protein similar to Saccharomyces cerevisiae mitochondrial protein YLR283W

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CCDC90-like super family cl06708
Coiled-coil domain-containing protein 90-like; This entry includes coiled-coil ...
 103-270 3.51e-16

Coiled-coil domain-containing protein 90-like; This entry includes coiled-coil domain-containing proteins 90 (CCDC90) and related proteins. CCDC90A is a key regulator of the mitochondrial calcium uniporter (MCU) and hence was renamed MCUR1. A study in mammals and in yeast homolog fmp32 has reported that MCUR1 is a cytochrome c oxidase assembly factor and that it has an indirect role as a regulator of MCU, however, subsequent publications confirmed the function of MCUR1 as a regulator of MCU. The role of CCDC90B proteins is still not known.


The actual alignment was detected with superfamily member pfam07798:

Pssm-ID: 462268 [Multi-domain]  Cd Length: 175  Bit Score: 74.86  E-value: 3.51e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323312    103 DTIKFYQMLrERGNFSDEQCKIIIALLLQLLNDQFYSCYNDLFLRDmELNKQSHLFSSLETELKFAIQNSRDTQLNEHHL 182
Cdd:pfam07798   2 DTHAFVRQL-EEAGFTEEQAEAIMKALRDLLNDSLENVSKDLVTKE-DLENETYLQKADLAELRSELQILEKSEFAALRS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323312    183 QLLKLKRELNSIHDELNEIIIDlLQKDAKLEFNNQKLENTLLYRQLNLKLNDCSNKIQTKIlGDIRSHIENLRWQTTRSG 262
Cdd:pfam07798  80 ENEKLRRELEKLKQRLREEITK-LKADVRLDLNLEKGRIREELKAQELKIQETNNKIDTEI-ANLRTQIESVKWDVIRYL 157


                  ....*...
gi 6323312    263 LLVILVLV 270
Cdd:pfam07798 158 IGVITGCL 165
 
Name Accession Description Interval E-value
CCDC90-like pfam07798
Coiled-coil domain-containing protein 90-like; This entry includes coiled-coil ...
 103-270 3.51e-16

Coiled-coil domain-containing protein 90-like; This entry includes coiled-coil domain-containing proteins 90 (CCDC90) and related proteins. CCDC90A is a key regulator of the mitochondrial calcium uniporter (MCU) and hence was renamed MCUR1. A study in mammals and in yeast homolog fmp32 has reported that MCUR1 is a cytochrome c oxidase assembly factor and that it has an indirect role as a regulator of MCU, however, subsequent publications confirmed the function of MCUR1 as a regulator of MCU. The role of CCDC90B proteins is still not known.


Pssm-ID: 462268 [Multi-domain]  Cd Length: 175  Bit Score: 74.86  E-value: 3.51e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323312    103 DTIKFYQMLrERGNFSDEQCKIIIALLLQLLNDQFYSCYNDLFLRDmELNKQSHLFSSLETELKFAIQNSRDTQLNEHHL 182
Cdd:pfam07798   2 DTHAFVRQL-EEAGFTEEQAEAIMKALRDLLNDSLENVSKDLVTKE-DLENETYLQKADLAELRSELQILEKSEFAALRS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323312    183 QLLKLKRELNSIHDELNEIIIDlLQKDAKLEFNNQKLENTLLYRQLNLKLNDCSNKIQTKIlGDIRSHIENLRWQTTRSG 262
Cdd:pfam07798  80 ENEKLRRELEKLKQRLREEITK-LKADVRLDLNLEKGRIREELKAQELKIQETNNKIDTEI-ANLRTQIESVKWDVIRYL 157


                  ....*...
gi 6323312    263 LLVILVLV 270
Cdd:pfam07798 158 IGVITGCL 165
 
Name Accession Description Interval E-value
CCDC90-like pfam07798
Coiled-coil domain-containing protein 90-like; This entry includes coiled-coil ...
 103-270 3.51e-16

Coiled-coil domain-containing protein 90-like; This entry includes coiled-coil domain-containing proteins 90 (CCDC90) and related proteins. CCDC90A is a key regulator of the mitochondrial calcium uniporter (MCU) and hence was renamed MCUR1. A study in mammals and in yeast homolog fmp32 has reported that MCUR1 is a cytochrome c oxidase assembly factor and that it has an indirect role as a regulator of MCU, however, subsequent publications confirmed the function of MCUR1 as a regulator of MCU. The role of CCDC90B proteins is still not known.


Pssm-ID: 462268 [Multi-domain]  Cd Length: 175  Bit Score: 74.86  E-value: 3.51e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323312    103 DTIKFYQMLrERGNFSDEQCKIIIALLLQLLNDQFYSCYNDLFLRDmELNKQSHLFSSLETELKFAIQNSRDTQLNEHHL 182
Cdd:pfam07798   2 DTHAFVRQL-EEAGFTEEQAEAIMKALRDLLNDSLENVSKDLVTKE-DLENETYLQKADLAELRSELQILEKSEFAALRS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323312    183 QLLKLKRELNSIHDELNEIIIDlLQKDAKLEFNNQKLENTLLYRQLNLKLNDCSNKIQTKIlGDIRSHIENLRWQTTRSG 262
Cdd:pfam07798  80 ENEKLRRELEKLKQRLREEITK-LKADVRLDLNLEKGRIREELKAQELKIQETNNKIDTEI-ANLRTQIESVKWDVIRYL 157


                  ....*...
gi 6323312    263 LLVILVLV 270
Cdd:pfam07798 158 IGVITGCL 165
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH