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Concise Results
Standard Results
Full Results
metalloendopeptidase [Saccharomyces cerevisiae S288C]
Protein Classification
M16 family metallopeptidase ( domain architecture ID 1000463 )
M16 family metallopeptidase is a zinc-dependent protease, similar to insulin-degrading enzyme (insulinase)
List of domain hits
Name
Accession
Description
Interval
E-value
Ptr super family
cl34066 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
66-1000
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
COG1025 :Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 876.10
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 66 K PDL D E R S YR F I E L P N K LK A LL IQ DP K ADK A AA S L D V NI G A F E DP KNLP GLAHF C EH L LF M G SE K F P DEN EY SSYL SKHG 145
Cdd:COG1025 37 K SPN D P R Q YR A I T L D N G LK V LL VS DP Q ADK S AA A L A V PV G S F D DP DDQQ GLAHF L EH M LF L G TK K Y P EPG EY QEFI SKHG 116
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 146 GS S NA Y TA SQN TNY F FEV NHQH L FG ALDRF SG FF SC PLF NKDST D K E I NAVN S E NKKNLQN D IW RIYQ LD K SLT N TK HP Y 225
Cdd:COG1025 117 GS H NA S TA TER TNY Y FEV ENDA L EE ALDRF AD FF AA PLF DPEYV D R E R NAVN A E YTLKRSD D GR RIYQ VH K ETL N PA HP F 196
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 226 HK FS T GN I ETL GTL P ken G LNV RDELL K F HKNF YSANLMKL CILGRED LD T L SDWTYDL F KDVA N NGRE VP LYAE P IMQ P 305
Cdd:COG1025 197 SR FS V GN L ETL SDK P --- G SKL RDELL A F YQRY YSANLMKL VLYSNQS LD E L EKLARQT F GAIP N RNLS VP PITV P LYT P 273
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 306 E H L QK II QVR P V K DLKK L EIS F TV P DMEEHWE SKP PRIL S H L I G H EG S GSLL AH LKK L G W A NE LSAGG HTVSKGNAF F AV 385
Cdd:COG1025 274 E Q L GI II HIV P L K PRRQ L RLE F PI P NNQAYYR SKP LTYI S Y L L G N EG E GSLL DW LKK Q G L A ES LSAGG GISGRNFGD F SI 353
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 386 DID LTD N GL T H YRDV I VLI F Q YIE MLKNSLP Q K W I F N E LQDISNAT F K F KQAGS P SST VS S L AKCLE kd YI PV SRI L AMG 465
Cdd:COG1025 354 SVS LTD K GL A H RDEI I AAV F A YIE LIRQQGI Q E W Y F D E QAQLLELA F R F QEKTR P MDY VS W L SDNML -- RY PV EDV L DAD 431
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 466 - L LTKYE P DLLTQYTDA L V PEN S R VT LIS RSLE TD SAEK WY G T A Y K V VDYPADLIKNMKSPGL NPAL T LP RP N EFVSTN F 544
Cdd:COG1025 432 y L MDGFD P AAIRARLAQ L T PEN A R IW LIS PDVP TD KTAY WY D T P Y S V DPITQEQLAKWQQASQ NPAL S LP EL N PYIPDD F 511
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 545 KVD K I D gi K PLDE P V LL LSDDVSK LWY KK D DR F WQ P RGY IYLS FKL P HTHA S II N SM L ST L YTQ L A NDAL KDVQ Y D A AC A 624
Cdd:COG1025 512 SLI K L D -- K ESAK P E LL VDEPGLR LWY MP D QY F AE P KAD IYLS LRN P QAVD S AR N QV L TR L LDY L L NDAL NELS Y Q A SV A 589
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 625 D L RI S FNKTNQ GL AIT ASGF NE K LII LL TRF L QGVN SFEP KKD RF EIL K DKTI R H L K N LLYEV PYSQ MSNYYNAIINERS 704
Cdd:COG1025 590 G L SY S LYAHQG GL TLS ASGF TQ K QPK LL EAL L DQLA SFEP TEE RF AQA K SQLL R Q L D N AEKAK PYSQ LFSPLSRLLQPPY 669
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 705 WSTA E K L QVF E KL T FEQ L IN F IPTIYEGVYF E T L IH GN IKH E E A LEVDSLI K SLIPN nih N LQVSNN R LRSYL L P K GKTF 784
Cdd:COG1025 670 FERE E L L AAL E SI T LQD L RA F REQLLQQLHL E M L VV GN LSE E Q A KQLADSL K KQLAP --- N GTGEEP R RQVVD L D K SGSL 746
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 785 RY E tal K DSQNVN S CIQHVT Q LD v Y SEDL S - ALS G L FA Q L I HEPC F DT LRT K EQLGYVV FSS -- S L NNH gt ANIRILI QS 861
Cdd:COG1025 747 NL E --- K ACDHTD S ALLIYY Q SG - Y DSLA S m ALS S L LG Q I I SPWF F NQ LRT E EQLGYVV GAG ym P L GRQ -- PGLGFYV QS 820
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 862 EHTT P - YL EW RI NN F YET F GQV L RDMP EE D F EKH K EA L C N S LL QKFK N MA EE SA R YTAA I YL GD YN F TH R Q K KAKL V ANI 940
Cdd:COG1025 821 PVAS P a YL LE RI DD F LKQ F EER L LALS EE E F AQY K QG L I N Q LL EPDQ N LS EE AQ R LWVD I GN GD FE F DT R E K LIAA V KKL 900
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 941 T KQQM IDF YENYIMSENASK L ILHLKSQVEN K E lneneldt AKYPTGQL I E D VG AF KS TL 1000
Cdd:COG1025 901 T RADL IDF FQQAVIAPQGLR L LSQSQGTKHS K A -------- DELKGWKT I T D IS AF QK TL 952
Name
Accession
Description
Interval
E-value
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
66-1000
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 876.10
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 66 K PDL D E R S YR F I E L P N K LK A LL IQ DP K ADK A AA S L D V NI G A F E DP KNLP GLAHF C EH L LF M G SE K F P DEN EY SSYL SKHG 145
Cdd:COG1025 37 K SPN D P R Q YR A I T L D N G LK V LL VS DP Q ADK S AA A L A V PV G S F D DP DDQQ GLAHF L EH M LF L G TK K Y P EPG EY QEFI SKHG 116
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 146 GS S NA Y TA SQN TNY F FEV NHQH L FG ALDRF SG FF SC PLF NKDST D K E I NAVN S E NKKNLQN D IW RIYQ LD K SLT N TK HP Y 225
Cdd:COG1025 117 GS H NA S TA TER TNY Y FEV ENDA L EE ALDRF AD FF AA PLF DPEYV D R E R NAVN A E YTLKRSD D GR RIYQ VH K ETL N PA HP F 196
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 226 HK FS T GN I ETL GTL P ken G LNV RDELL K F HKNF YSANLMKL CILGRED LD T L SDWTYDL F KDVA N NGRE VP LYAE P IMQ P 305
Cdd:COG1025 197 SR FS V GN L ETL SDK P --- G SKL RDELL A F YQRY YSANLMKL VLYSNQS LD E L EKLARQT F GAIP N RNLS VP PITV P LYT P 273
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 306 E H L QK II QVR P V K DLKK L EIS F TV P DMEEHWE SKP PRIL S H L I G H EG S GSLL AH LKK L G W A NE LSAGG HTVSKGNAF F AV 385
Cdd:COG1025 274 E Q L GI II HIV P L K PRRQ L RLE F PI P NNQAYYR SKP LTYI S Y L L G N EG E GSLL DW LKK Q G L A ES LSAGG GISGRNFGD F SI 353
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 386 DID LTD N GL T H YRDV I VLI F Q YIE MLKNSLP Q K W I F N E LQDISNAT F K F KQAGS P SST VS S L AKCLE kd YI PV SRI L AMG 465
Cdd:COG1025 354 SVS LTD K GL A H RDEI I AAV F A YIE LIRQQGI Q E W Y F D E QAQLLELA F R F QEKTR P MDY VS W L SDNML -- RY PV EDV L DAD 431
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 466 - L LTKYE P DLLTQYTDA L V PEN S R VT LIS RSLE TD SAEK WY G T A Y K V VDYPADLIKNMKSPGL NPAL T LP RP N EFVSTN F 544
Cdd:COG1025 432 y L MDGFD P AAIRARLAQ L T PEN A R IW LIS PDVP TD KTAY WY D T P Y S V DPITQEQLAKWQQASQ NPAL S LP EL N PYIPDD F 511
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 545 KVD K I D gi K PLDE P V LL LSDDVSK LWY KK D DR F WQ P RGY IYLS FKL P HTHA S II N SM L ST L YTQ L A NDAL KDVQ Y D A AC A 624
Cdd:COG1025 512 SLI K L D -- K ESAK P E LL VDEPGLR LWY MP D QY F AE P KAD IYLS LRN P QAVD S AR N QV L TR L LDY L L NDAL NELS Y Q A SV A 589
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 625 D L RI S FNKTNQ GL AIT ASGF NE K LII LL TRF L QGVN SFEP KKD RF EIL K DKTI R H L K N LLYEV PYSQ MSNYYNAIINERS 704
Cdd:COG1025 590 G L SY S LYAHQG GL TLS ASGF TQ K QPK LL EAL L DQLA SFEP TEE RF AQA K SQLL R Q L D N AEKAK PYSQ LFSPLSRLLQPPY 669
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 705 WSTA E K L QVF E KL T FEQ L IN F IPTIYEGVYF E T L IH GN IKH E E A LEVDSLI K SLIPN nih N LQVSNN R LRSYL L P K GKTF 784
Cdd:COG1025 670 FERE E L L AAL E SI T LQD L RA F REQLLQQLHL E M L VV GN LSE E Q A KQLADSL K KQLAP --- N GTGEEP R RQVVD L D K SGSL 746
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 785 RY E tal K DSQNVN S CIQHVT Q LD v Y SEDL S - ALS G L FA Q L I HEPC F DT LRT K EQLGYVV FSS -- S L NNH gt ANIRILI QS 861
Cdd:COG1025 747 NL E --- K ACDHTD S ALLIYY Q SG - Y DSLA S m ALS S L LG Q I I SPWF F NQ LRT E EQLGYVV GAG ym P L GRQ -- PGLGFYV QS 820
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 862 EHTT P - YL EW RI NN F YET F GQV L RDMP EE D F EKH K EA L C N S LL QKFK N MA EE SA R YTAA I YL GD YN F TH R Q K KAKL V ANI 940
Cdd:COG1025 821 PVAS P a YL LE RI DD F LKQ F EER L LALS EE E F AQY K QG L I N Q LL EPDQ N LS EE AQ R LWVD I GN GD FE F DT R E K LIAA V KKL 900
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 941 T KQQM IDF YENYIMSENASK L ILHLKSQVEN K E lneneldt AKYPTGQL I E D VG AF KS TL 1000
Cdd:COG1025 901 T RADL IDF FQQAVIAPQGLR L LSQSQGTKHS K A -------- DELKGWKT I T D IS AF QK TL 952
PRK15101
PRK15101 protease3; Provisional
66-1007
3.54e-140
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 444.81
E-value: 3.54e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 66 K PDL D E R S Y RF I E L P N KLKA LL IQ DP K A D K AA A S L DVNI G AF EDP KNLP GLAH FC EH LLF MGS E K F P DENEYSSY L S KHG 145
Cdd:PRK15101 36 K SEK D P R Q Y QA I R L D N GMTV LL VS DP Q A V K SL A A L ALPV G SL EDP DAQQ GLAH YL EH MVL MGS K K Y P QPDSLAEF L K KHG 115
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 146 GS S NA Y TAS QN T NYFF EV NHQH L FG A L DR FSGFFSC PL FNKDST D K E I NAVN S E NKKNLQN D IW R IY Q LDKSLT N TK HP Y 225
Cdd:PRK15101 116 GS H NA S TAS YR T AFYL EV ENDA L PP A V DR LADAIAE PL LDPKNA D R E R NAVN A E LTMARSR D GM R MA Q VSAETI N PA HP G 195
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 226 HK FS T GN I ETL GTL P ken G LNVR D E L LK F HKNF YSANLMK LC I LGRED L DT L SDWTY D L F KD V A N NGRE VP LYAE P IMQP 305
Cdd:PRK15101 196 SR FS G GN L ETL SDK P --- G SKLQ D A L VD F YQRY YSANLMK AV I YSNQP L PE L AKLAA D T F GR V P N KNAS VP EITV P VVTD 272
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 306 E hl QK -- II QVR P VKDL K K L EIS F TVPDMEEHWE SK PPRIL S H LIG HEGS G S L LAH L K K L G W A NEL SAG GHTVSKG N A - F 382
Cdd:PRK15101 273 A -- QK gi II HYV P AQPR K V L RVE F RIDNNSAKFR SK TDEYI S Y LIG NRSP G T L SDW L Q K Q G L A EGI SAG ADPMVDR N S g V 350
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 383 FA VDID LTD N GL THYRD V IVL IF Q Y IEM L KNSLPQ K WI F N EL QDISNAT F KF kqags PS S T VSS lakclek DYI ------ 456
Cdd:PRK15101 351 FA ISVS LTD K GL AQRDQ V VAA IF S Y LNL L REKGID K SY F D EL AHVLDLD F RY ----- PS I T RDM ------- DYI ewladt 418
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 457 ---- PV SRI L - A MGLLTK Y E P DLLTQYTDALV P E N S R VTL IS RSLETDSAEKWYGTA Y K V VDYPADLIKNMKSPGL N P AL 531
Cdd:PRK15101 419 mlrv PV EHT L d A PYIADR Y D P KAIKARLAEMT P Q N A R IWY IS PQEPHNKTAYFVDAP Y Q V DKISEQTFADWQQKAQ N I AL 498
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 532 T LP RP N EFVSTN F KVD K I D gi K PLDE P V L LLSDDVSKLW Y KKDDR F WQ - P RGY I Y L SFKL P HTHA S II N SM L ST L YTQ LA 610
Cdd:PRK15101 499 S LP EL N PYIPDD F SLI K A D -- K AYKH P E L IVDEPGLRVV Y MPSQY F AD e P KAD I S L VLRN P KAMD S AR N QV L FA L NDY LA 576
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 611 ND AL KDVQYD A ACADLRI S F N k T N Q GL AIT A S G FNEK L II LL TRF L Q G VN SF E P KKDRFEIL K ---------------- D 674
Cdd:PRK15101 577 GL AL DQLSNQ A SVGGISF S T N - A N N GL MVN A N G YTQR L PQ LL QAL L E G YF SF T P TEEQLAQA K swyreqldsaekgkay E 655
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 675 KT I RHLKN l L YE VPY SQMS nyynaiinerswsta E KLQVFEKL T FEQLINFIPTIYE G VYF E T L IH GN IKH E EALEVDSL 754
Cdd:PRK15101 656 QA I MPAQM - L SQ VPY FERD --------------- E RRKLLPSI T LKDVLAYRDALLS G ATP E F L VV GN LTE E QVTTLARD 719
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 755 IKSLIPNN ---- IHNLQ V SNNRLR S YLLP K gktfryetalkdsq NVN S CIQHVTQLD V --- Y S E - DL SA L S G L FA Q L I HE 826
Cdd:PRK15101 720 VQKQLGAD gtew WRGKD V VVDKKQ S VNFE K -------------- AGS S TDSALAAVY V ptg Y D E y QS SA Y S S L LG Q I I QP 785
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 827 PCFDT LRT K EQLGY V VF SSSLNNHGTANIRI L I QS EHTT P - YL EW R INN F YETFGQV LR D M PE E D F EKHKE AL C N S LLQ K 905
Cdd:PRK15101 786 WFYNQ LRT E EQLGY A VF AFPMSVGRQWGMGF L L QS NDKQ P a YL WQ R YQA F FPQAEAK LR A M KP E E F AQYQQ AL I N Q LLQ A 865
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 906 FKNMA EE SA R YTAAIYL G DYN F TH R Q K KAKLVANI T K Q QMI DF YENYIMSENASKLI lhlk SQ VENK el NENEL D T A KYP 985
Cdd:PRK15101 866 PQTLG EE AS R LSKDFDR G NMR F DS R D K IIAQIKLL T P Q KLA DF FHQAVIEPQGLAIL ---- SQ ISGS -- QNGKA D Y A HPK 939
970 980
....*....|....*....|..
gi 42742289 986 TGQLI E D V G A FKS TL fva PV RQ 1007
Cdd:PRK15101 940 GWKTW E N V S A LQQ TL --- PV ME 958
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
432-713
2.32e-98
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 311.81
E-value: 2.32e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 432 F K F KQAGS PS ST VSSLA KCLE kd YI P VSR IL AMG - LL TK Y E P D L LTQYT D A L V PEN S R V TL I S RSL E -- TD SA E K WYGT A 508
Cdd:pfam16187 1 F R F QEKSP PS DY VSSLA SNMQ -- PY P PED IL SGD y LL RE Y D P E L IQELL D Y L T PEN A R I TL V S KEF E ge TD QK E P WYGT E 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 509 Y K V VDY P AD L I K NM K S - P GL NP A L T LP R PN E F VS T N F KVD K IDGIK P LDE PVL LLSDDV S K LWYKKDD R FW Q P RGY IYLS 587
Cdd:pfam16187 79 Y S V EPI P EE L L K KW K N a P EP NP E L H LP E PN P F IP T D F DLK K KEVKE P AKY PVL IRDTPL S R LWYKKDD T FW V P KAN IYLS 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 588 FKL P HTHA S II N SM L ST LY TQ L AN D A L KDVQ YDA AC A D L RI S FNK T NQ GL AITA SG F N E KL II LL TRF L QGVNS FE PKK D 667
Cdd:pfam16187 159 LRS P LAYS S PR N AV L TR LY VE L LK D S L NEYA YDA EL A G L SY S LSA T ER GL TLSV SG Y N D KL PV LL EKI L EKLRD FE IDP D 238
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 42742289 668 RFEI L K DKTI R HL KN LLY E V PY S Q MSN Y YNAIIN ERSW STA EKL QV 713
Cdd:pfam16187 239 RFEI I K EQLL R SY KN FAL E Q PY Q Q AFD Y LLYLLE ERSW TPE EKL EA 284
PQQ_syn_pqqF
TIGR02110 coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme ...
75-412
3.69e-32
coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme PQQ (pyrrolo-quinoline-quinone), this probable peptidase is found in the PQQ biosynthesis region and is thought to act as a protease on PqqA (TIGR02107), a probable peptide precursor of the coenzyme. PQQ is required for some glucose dehydrogenases and alcohol dehydrogenases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Pssm-ID: 273978 [Multi-domain]
Cd Length: 697
Bit Score: 134.23
E-value: 3.69e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 75 R F I E LPN K L KAL L IQD P K A DK AAA S L D V NI G AFED P KNL PGLAHF C EHLLF M G S E K F PDENEYSSYLSKH GG SS NA Y T AS 154
Cdd:TIGR02110 1 R R I T LPN G L RVH L YHQ P D A KR AAA L L R V AA G SHDE P SAW PGLAHF L EHLLF L G G E R F QGDDRLMPWVQRQ GG QV NA T T LE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 155 QN T NY FFE VNHQH L FGA L D R FSGFFSC PL FNKDSTDK E INAVNS E NKK n L QND IWRIYQ --- LD K sl TNTK HP YHK F ST G 231
Cdd:TIGR02110 81 RT T AF FFE LPAAA L AAG L A R LCDMLAR PL LTAEDQQR E REVLEA E YIA - W QND ADTLRE aal LD A -- LQAG HP LRR F HA G 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 232 NIET L GT lpke NGLNVRDE L LK FH KNF Y S A NL M K L CIL G RED LD T L SDWTYDLFKDV A n N G R E VPLYAE - P IMQPEH L QK 310
Cdd:TIGR02110 158 SRDS L AL ---- PNTAFQQA L RD FH RRH Y Q A GN M Q L WLQ G PQS LD E L EQLAARFGASL A - A G G E CAQAPP a P LLRFDR L TL 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 311 IIQVR P VKD L kklei S F TV p DMEEHWESKPPRI L SHLIGH E GS G S LLA H L KKL G W A NELS A GGHTVSK G N A FF A VDIDLT 390
Cdd:TIGR02110 233 AGGSE P RLW L ----- L F AL - AGLPATARDNVTL L CEFLQD E AP G G LLA Q L RER G L A ESVA A TWLYQDA G Q A LL A LEFSAR 306
330 340
....*....|....*....|..
gi 42742289 391 DNGLTHYRDVIV L IF Q YIEM L K 412
Cdd:TIGR02110 307 CISAAAAQQIEQ L LT Q WLGA L A 328
Name
Accession
Description
Interval
E-value
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
66-1000
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 876.10
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 66 K PDL D E R S YR F I E L P N K LK A LL IQ DP K ADK A AA S L D V NI G A F E DP KNLP GLAHF C EH L LF M G SE K F P DEN EY SSYL SKHG 145
Cdd:COG1025 37 K SPN D P R Q YR A I T L D N G LK V LL VS DP Q ADK S AA A L A V PV G S F D DP DDQQ GLAHF L EH M LF L G TK K Y P EPG EY QEFI SKHG 116
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 146 GS S NA Y TA SQN TNY F FEV NHQH L FG ALDRF SG FF SC PLF NKDST D K E I NAVN S E NKKNLQN D IW RIYQ LD K SLT N TK HP Y 225
Cdd:COG1025 117 GS H NA S TA TER TNY Y FEV ENDA L EE ALDRF AD FF AA PLF DPEYV D R E R NAVN A E YTLKRSD D GR RIYQ VH K ETL N PA HP F 196
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 226 HK FS T GN I ETL GTL P ken G LNV RDELL K F HKNF YSANLMKL CILGRED LD T L SDWTYDL F KDVA N NGRE VP LYAE P IMQ P 305
Cdd:COG1025 197 SR FS V GN L ETL SDK P --- G SKL RDELL A F YQRY YSANLMKL VLYSNQS LD E L EKLARQT F GAIP N RNLS VP PITV P LYT P 273
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 306 E H L QK II QVR P V K DLKK L EIS F TV P DMEEHWE SKP PRIL S H L I G H EG S GSLL AH LKK L G W A NE LSAGG HTVSKGNAF F AV 385
Cdd:COG1025 274 E Q L GI II HIV P L K PRRQ L RLE F PI P NNQAYYR SKP LTYI S Y L L G N EG E GSLL DW LKK Q G L A ES LSAGG GISGRNFGD F SI 353
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 386 DID LTD N GL T H YRDV I VLI F Q YIE MLKNSLP Q K W I F N E LQDISNAT F K F KQAGS P SST VS S L AKCLE kd YI PV SRI L AMG 465
Cdd:COG1025 354 SVS LTD K GL A H RDEI I AAV F A YIE LIRQQGI Q E W Y F D E QAQLLELA F R F QEKTR P MDY VS W L SDNML -- RY PV EDV L DAD 431
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 466 - L LTKYE P DLLTQYTDA L V PEN S R VT LIS RSLE TD SAEK WY G T A Y K V VDYPADLIKNMKSPGL NPAL T LP RP N EFVSTN F 544
Cdd:COG1025 432 y L MDGFD P AAIRARLAQ L T PEN A R IW LIS PDVP TD KTAY WY D T P Y S V DPITQEQLAKWQQASQ NPAL S LP EL N PYIPDD F 511
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 545 KVD K I D gi K PLDE P V LL LSDDVSK LWY KK D DR F WQ P RGY IYLS FKL P HTHA S II N SM L ST L YTQ L A NDAL KDVQ Y D A AC A 624
Cdd:COG1025 512 SLI K L D -- K ESAK P E LL VDEPGLR LWY MP D QY F AE P KAD IYLS LRN P QAVD S AR N QV L TR L LDY L L NDAL NELS Y Q A SV A 589
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 625 D L RI S FNKTNQ GL AIT ASGF NE K LII LL TRF L QGVN SFEP KKD RF EIL K DKTI R H L K N LLYEV PYSQ MSNYYNAIINERS 704
Cdd:COG1025 590 G L SY S LYAHQG GL TLS ASGF TQ K QPK LL EAL L DQLA SFEP TEE RF AQA K SQLL R Q L D N AEKAK PYSQ LFSPLSRLLQPPY 669
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 705 WSTA E K L QVF E KL T FEQ L IN F IPTIYEGVYF E T L IH GN IKH E E A LEVDSLI K SLIPN nih N LQVSNN R LRSYL L P K GKTF 784
Cdd:COG1025 670 FERE E L L AAL E SI T LQD L RA F REQLLQQLHL E M L VV GN LSE E Q A KQLADSL K KQLAP --- N GTGEEP R RQVVD L D K SGSL 746
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 785 RY E tal K DSQNVN S CIQHVT Q LD v Y SEDL S - ALS G L FA Q L I HEPC F DT LRT K EQLGYVV FSS -- S L NNH gt ANIRILI QS 861
Cdd:COG1025 747 NL E --- K ACDHTD S ALLIYY Q SG - Y DSLA S m ALS S L LG Q I I SPWF F NQ LRT E EQLGYVV GAG ym P L GRQ -- PGLGFYV QS 820
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 862 EHTT P - YL EW RI NN F YET F GQV L RDMP EE D F EKH K EA L C N S LL QKFK N MA EE SA R YTAA I YL GD YN F TH R Q K KAKL V ANI 940
Cdd:COG1025 821 PVAS P a YL LE RI DD F LKQ F EER L LALS EE E F AQY K QG L I N Q LL EPDQ N LS EE AQ R LWVD I GN GD FE F DT R E K LIAA V KKL 900
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 941 T KQQM IDF YENYIMSENASK L ILHLKSQVEN K E lneneldt AKYPTGQL I E D VG AF KS TL 1000
Cdd:COG1025 901 T RADL IDF FQQAVIAPQGLR L LSQSQGTKHS K A -------- DELKGWKT I T D IS AF QK TL 952
PRK15101
PRK15101 protease3; Provisional
66-1007
3.54e-140
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 444.81
E-value: 3.54e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 66 K PDL D E R S Y RF I E L P N KLKA LL IQ DP K A D K AA A S L DVNI G AF EDP KNLP GLAH FC EH LLF MGS E K F P DENEYSSY L S KHG 145
Cdd:PRK15101 36 K SEK D P R Q Y QA I R L D N GMTV LL VS DP Q A V K SL A A L ALPV G SL EDP DAQQ GLAH YL EH MVL MGS K K Y P QPDSLAEF L K KHG 115
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 146 GS S NA Y TAS QN T NYFF EV NHQH L FG A L DR FSGFFSC PL FNKDST D K E I NAVN S E NKKNLQN D IW R IY Q LDKSLT N TK HP Y 225
Cdd:PRK15101 116 GS H NA S TAS YR T AFYL EV ENDA L PP A V DR LADAIAE PL LDPKNA D R E R NAVN A E LTMARSR D GM R MA Q VSAETI N PA HP G 195
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 226 HK FS T GN I ETL GTL P ken G LNVR D E L LK F HKNF YSANLMK LC I LGRED L DT L SDWTY D L F KD V A N NGRE VP LYAE P IMQP 305
Cdd:PRK15101 196 SR FS G GN L ETL SDK P --- G SKLQ D A L VD F YQRY YSANLMK AV I YSNQP L PE L AKLAA D T F GR V P N KNAS VP EITV P VVTD 272
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 306 E hl QK -- II QVR P VKDL K K L EIS F TVPDMEEHWE SK PPRIL S H LIG HEGS G S L LAH L K K L G W A NEL SAG GHTVSKG N A - F 382
Cdd:PRK15101 273 A -- QK gi II HYV P AQPR K V L RVE F RIDNNSAKFR SK TDEYI S Y LIG NRSP G T L SDW L Q K Q G L A EGI SAG ADPMVDR N S g V 350
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 383 FA VDID LTD N GL THYRD V IVL IF Q Y IEM L KNSLPQ K WI F N EL QDISNAT F KF kqags PS S T VSS lakclek DYI ------ 456
Cdd:PRK15101 351 FA ISVS LTD K GL AQRDQ V VAA IF S Y LNL L REKGID K SY F D EL AHVLDLD F RY ----- PS I T RDM ------- DYI ewladt 418
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 457 ---- PV SRI L - A MGLLTK Y E P DLLTQYTDALV P E N S R VTL IS RSLETDSAEKWYGTA Y K V VDYPADLIKNMKSPGL N P AL 531
Cdd:PRK15101 419 mlrv PV EHT L d A PYIADR Y D P KAIKARLAEMT P Q N A R IWY IS PQEPHNKTAYFVDAP Y Q V DKISEQTFADWQQKAQ N I AL 498
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 532 T LP RP N EFVSTN F KVD K I D gi K PLDE P V L LLSDDVSKLW Y KKDDR F WQ - P RGY I Y L SFKL P HTHA S II N SM L ST L YTQ LA 610
Cdd:PRK15101 499 S LP EL N PYIPDD F SLI K A D -- K AYKH P E L IVDEPGLRVV Y MPSQY F AD e P KAD I S L VLRN P KAMD S AR N QV L FA L NDY LA 576
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 611 ND AL KDVQYD A ACADLRI S F N k T N Q GL AIT A S G FNEK L II LL TRF L Q G VN SF E P KKDRFEIL K ---------------- D 674
Cdd:PRK15101 577 GL AL DQLSNQ A SVGGISF S T N - A N N GL MVN A N G YTQR L PQ LL QAL L E G YF SF T P TEEQLAQA K swyreqldsaekgkay E 655
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 675 KT I RHLKN l L YE VPY SQMS nyynaiinerswsta E KLQVFEKL T FEQLINFIPTIYE G VYF E T L IH GN IKH E EALEVDSL 754
Cdd:PRK15101 656 QA I MPAQM - L SQ VPY FERD --------------- E RRKLLPSI T LKDVLAYRDALLS G ATP E F L VV GN LTE E QVTTLARD 719
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 755 IKSLIPNN ---- IHNLQ V SNNRLR S YLLP K gktfryetalkdsq NVN S CIQHVTQLD V --- Y S E - DL SA L S G L FA Q L I HE 826
Cdd:PRK15101 720 VQKQLGAD gtew WRGKD V VVDKKQ S VNFE K -------------- AGS S TDSALAAVY V ptg Y D E y QS SA Y S S L LG Q I I QP 785
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 827 PCFDT LRT K EQLGY V VF SSSLNNHGTANIRI L I QS EHTT P - YL EW R INN F YETFGQV LR D M PE E D F EKHKE AL C N S LLQ K 905
Cdd:PRK15101 786 WFYNQ LRT E EQLGY A VF AFPMSVGRQWGMGF L L QS NDKQ P a YL WQ R YQA F FPQAEAK LR A M KP E E F AQYQQ AL I N Q LLQ A 865
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 906 FKNMA EE SA R YTAAIYL G DYN F TH R Q K KAKLVANI T K Q QMI DF YENYIMSENASKLI lhlk SQ VENK el NENEL D T A KYP 985
Cdd:PRK15101 866 PQTLG EE AS R LSKDFDR G NMR F DS R D K IIAQIKLL T P Q KLA DF FHQAVIEPQGLAIL ---- SQ ISGS -- QNGKA D Y A HPK 939
970 980
....*....|....*....|..
gi 42742289 986 TGQLI E D V G A FKS TL fva PV RQ 1007
Cdd:PRK15101 940 GWKTW E N V S A LQQ TL --- PV ME 958
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
432-713
2.32e-98
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 311.81
E-value: 2.32e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 432 F K F KQAGS PS ST VSSLA KCLE kd YI P VSR IL AMG - LL TK Y E P D L LTQYT D A L V PEN S R V TL I S RSL E -- TD SA E K WYGT A 508
Cdd:pfam16187 1 F R F QEKSP PS DY VSSLA SNMQ -- PY P PED IL SGD y LL RE Y D P E L IQELL D Y L T PEN A R I TL V S KEF E ge TD QK E P WYGT E 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 509 Y K V VDY P AD L I K NM K S - P GL NP A L T LP R PN E F VS T N F KVD K IDGIK P LDE PVL LLSDDV S K LWYKKDD R FW Q P RGY IYLS 587
Cdd:pfam16187 79 Y S V EPI P EE L L K KW K N a P EP NP E L H LP E PN P F IP T D F DLK K KEVKE P AKY PVL IRDTPL S R LWYKKDD T FW V P KAN IYLS 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 588 FKL P HTHA S II N SM L ST LY TQ L AN D A L KDVQ YDA AC A D L RI S FNK T NQ GL AITA SG F N E KL II LL TRF L QGVNS FE PKK D 667
Cdd:pfam16187 159 LRS P LAYS S PR N AV L TR LY VE L LK D S L NEYA YDA EL A G L SY S LSA T ER GL TLSV SG Y N D KL PV LL EKI L EKLRD FE IDP D 238
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 42742289 668 RFEI L K DKTI R HL KN LLY E V PY S Q MSN Y YNAIIN ERSW STA EKL QV 713
Cdd:pfam16187 239 RFEI I K EQLL R SY KN FAL E Q PY Q Q AFD Y LLYLLE ERSW TPE EKL EA 284
PqqL
COG0612 Predicted Zn-dependent peptidase, M16 family [General function prediction only];
74-416
8.68e-38
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
Pssm-ID: 440377 [Multi-domain]
Cd Length: 427
Bit Score: 147.38
E-value: 8.68e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 74 YRFIE LPN K L KAL L IQ DP K A DKAAAS L D V NI G AFED P KNLP GLAHF C EH L LF M G SE K FP d EN E YSSY L SKH GGS S NA Y T A 153
Cdd:COG0612 15 VEEFT LPN G L RVI L VP DP E A PVVSVR L W V RV G SRDE P PGKT GLAHF L EH M LF K G TK K RS - AG E IAEE L EAL GGS L NA F T S 93
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 154 SQN T N Y FFE V NHQH L FG AL DRFSGFFSC P L F NKDSTDK E INA V NS E NKKNLQNDIWRIY - Q L DKS L TN t K HPY HKFST G N 232
Cdd:COG0612 94 FDY T V Y YLS V LSED L EL AL ELLADRLLN P T F DEEELER E RGV V LE E IRRYEDDPDGLAF e A L LAA L YG - D HPY GRPII G T 172
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 233 I E TLGTLP kenglnv R DE L LK F H K NF Y SA N LMK L CIL G RE D LDTLSDWTYDL F K D VANNGREVPLYAEP imq P EHLQKII 312
Cdd:COG0612 173 E E SIEAIT ------- R ED L RA F Y K RY Y RP N NAV L VVV G DV D PEEVLALVEKY F G D LPAGPAPPRPDPAE --- P PQTGPRR 242
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 313 Q V RPVK D LKK -- LEISFTV P DM e EHWESKPPRI L SHLI G H e G SG S L L AHL -- K K L G W A NELSA g GHTVSKGNAF F AVDID 388
Cdd:COG0612 243 V V VDDP D AEQ ah ILLGYPG P AR - DDPDYYALDV L NEIL G G - G FS S R L FQE lr E K K G L A YSVGS - SFSPYRDAGL F TIYAG 319
330 340
....*....|....*....|....*...
gi 42742289 389 LTDNG L thy RDVIVL I FQYI E M L KNSLP 416
Cdd:COG0612 320 TAPDK L --- EEALAA I LEEL E R L AKEGV 344
Peptidase_M16
pfam00675 Insulinase (Peptidase family M16);
84-222
1.05e-35
Insulinase (Peptidase family M16);
Pssm-ID: 425812 [Multi-domain]
Cd Length: 149
Bit Score: 132.43
E-value: 1.05e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 84 KALLIQ DP K AD KAAAS L DVNI G AFED P K N LP GLAHF C EH LL F M G SE K F P D e NE YSSY L S K H GGS S NA Y T ASQ NT N Y FF EV 163
Cdd:pfam00675 1 RVASES DP P AD TSTVG L WIDA G SRYE P D N NN GLAHF L EH MA F K G TK K Y P S - NE LEEE L E K L GGS L NA F T SRE NT V Y YA EV 79
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 164 NHQH L FG A L DR FSG FF SC PLF N ------- KDSTDK E IN AV N SE NKK ---- NL QNDIW R IYQ L DK SL TNTK 222
Cdd:pfam00675 80 LNDD L PK A V DR LAD FF RN PLF T eseiere RLVVLY E VE AV D SE PQL vvle NL HAAAY R NTP L GR SL LGPG 149
PQQ_syn_pqqF
TIGR02110 coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme ...
75-412
3.69e-32
coenzyme PQQ biosynthesis probable peptidase PqqF; In a subset of species that make coenzyme PQQ (pyrrolo-quinoline-quinone), this probable peptidase is found in the PQQ biosynthesis region and is thought to act as a protease on PqqA (TIGR02107), a probable peptide precursor of the coenzyme. PQQ is required for some glucose dehydrogenases and alcohol dehydrogenases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Pssm-ID: 273978 [Multi-domain]
Cd Length: 697
Bit Score: 134.23
E-value: 3.69e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 75 R F I E LPN K L KAL L IQD P K A DK AAA S L D V NI G AFED P KNL PGLAHF C EHLLF M G S E K F PDENEYSSYLSKH GG SS NA Y T AS 154
Cdd:TIGR02110 1 R R I T LPN G L RVH L YHQ P D A KR AAA L L R V AA G SHDE P SAW PGLAHF L EHLLF L G G E R F QGDDRLMPWVQRQ GG QV NA T T LE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 155 QN T NY FFE VNHQH L FGA L D R FSGFFSC PL FNKDSTDK E INAVNS E NKK n L QND IWRIYQ --- LD K sl TNTK HP YHK F ST G 231
Cdd:TIGR02110 81 RT T AF FFE LPAAA L AAG L A R LCDMLAR PL LTAEDQQR E REVLEA E YIA - W QND ADTLRE aal LD A -- LQAG HP LRR F HA G 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 232 NIET L GT lpke NGLNVRDE L LK FH KNF Y S A NL M K L CIL G RED LD T L SDWTYDLFKDV A n N G R E VPLYAE - P IMQPEH L QK 310
Cdd:TIGR02110 158 SRDS L AL ---- PNTAFQQA L RD FH RRH Y Q A GN M Q L WLQ G PQS LD E L EQLAARFGASL A - A G G E CAQAPP a P LLRFDR L TL 232
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 311 IIQVR P VKD L kklei S F TV p DMEEHWESKPPRI L SHLIGH E GS G S LLA H L KKL G W A NELS A GGHTVSK G N A FF A VDIDLT 390
Cdd:TIGR02110 233 AGGSE P RLW L ----- L F AL - AGLPATARDNVTL L CEFLQD E AP G G LLA Q L RER G L A ESVA A TWLYQDA G Q A LL A LEFSAR 306
330 340
....*....|....*....|..
gi 42742289 391 DNGLTHYRDVIV L IF Q YIEM L K 412
Cdd:TIGR02110 307 CISAAAAQQIEQ L LT Q WLGA L A 328
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
248-427
1.71e-28
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 112.87
E-value: 1.71e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 248 R DE L LK F H K NF YS ANL M K L C I L G RE D LDT L S D WTYDL F K D V an NGREVPLYAE P IMQ P EH L QKIIQ V R P V KD LK -- K L EI 325
Cdd:pfam05193 4 R ED L RD F Y K KH YS PDN M V L V I V G DV D HEE L L D LAEKY F G D L -- PASPKGKPRP P PLE P AK L KGREV V V P K KD EP qa H L AL 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 326 S F TV P DMEEHWE S KPPRI L SH L I G HEG S GS L LAH L K - K L G W A NEL S A g GHTVSKGNAF F AVDIDLTDN glt HYRD VI V LI 404
Cdd:pfam05193 82 A F PG P PLNNDED S LALDV L NE L L G GGM S SR L FQE L R e K E G L A YSV S S - FNDSYSDSGL F GIYATVDPE --- NVDE VI E LI 157
170 180
....*....|....*....|...
gi 42742289 405 FQYI E M L KNSLPQKWIFNELQDI 427
Cdd:pfam05193 158 LEEL E K L AQEGVTEEELERAKNQ 180
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
716-898
4.07e-17
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 80.13
E-value: 4.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 716 K LT F E Q L IN F IPTI Y EGVYFETL I H G NIK HEE A L E - VDSLIKS L IPNNIHNLQ vsn NRLRSYLLP KG KTFRYET a LKDS Q 794
Cdd:pfam05193 1 S LT R E D L RD F YKKH Y SPDNMVLV I V G DVD HEE L L D l AEKYFGD L PASPKGKPR --- PPPLEPAKL KG REVVVPK - KDEP Q 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42742289 795 NVNSCIQHVTQ L -- D VY S ED L SA L SG L FAQLIHEPC F DT LR T KE Q L G Y V V F S S -- S LNNH G TAN I RILIQS E H ttpy LEW 870
Cdd:pfam05193 77 AHLALAFPGPP L nn D ED S LA L DV L NE L LGGGMSSRL F QE LR E KE G L A Y S V S S F nd S YSDS G LFG I YATVDP E N ---- VDE 152
170 180
....*....|....*....|....*....
gi 42742289 871 R I NNFY E TFGQVLRD - MP EE DF E KH K EA L 898
Cdd:pfam05193 153 V I ELIL E ELEKLAQE g VT EE EL E RA K NQ L 181
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
