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Conserved domains on  [gi|6323534|ref|NP_013605|]
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Cac2p [Saccharomyces cerevisiae S288C]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12822048)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
13-214 1.01e-24

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.76  E-value: 1.01e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534   13 SQPVYSLTFqknSANDK-LFTAGGDNKVRIWKLNRDEngqnggvrkiesldFLGSLTHHEQAINVIRFNSKGDVLASAGD 91
Cdd:COG2319 204 TGAVRSVAF---SPDGKlLASGSADGTVRLWDLATGK--------------LLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534   92 DGQVLLWkqedpntqqesvvrpfgmDAETSEadenkekwvVWKRLRGGSGAtaaaeIYDLAWSPDNRNIVVACMDNSIRL 171
Cdd:COG2319 267 DGTVRLW------------------DLATGE---------LLRTLTGHSGG-----VNSVAFSPDGKLLASGSDDGTVRL 314

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 6323534  172 FDVGAGMLVCGQSDHGHYVQGVAWDPLNQFILSQSADRSLHVY 214
Cdd:COG2319 315 WDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 70-395 2.72e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 66.97  E-value: 2.72e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534   70 HEQAINVIRFNSKGDVLASAGDDGQVLLWKQEDPNTQqesvvrpfgmdaetseadenkekwvvwKRLRGGSGataaaEIY 149
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELL---------------------------RTLKGHTG-----PVR 55

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534  150 DLAWSPDNRNIVVACMDNSIRLFDVGAGMLVCGQSDHGHYVQGVAWDPLNQFILSQSADRSLHVYGVIlssagvvTGlkl 229
Cdd:cd00200  56 DVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE-------TG--- 125

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534  230 rskiakaelpcpgdVLRTNYLFHNETLPSffrrCSISPCGGLVVIPSG-----VYKVAG-----------DEVaNCVYVY 293
Cdd:cd00200 126 --------------KCLTTLRGHTDWVNS----VAFSPDGTFVASSSQdgtikLWDLRTgkcvatltghtGEV-NSVAFS 186

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534  294 TRSGILNSAGGVKNrpaIRIPSLKKPALMAAF----SPVFyetcqkSVLKLPYKLVFAIATTNEVL-VYDTDVLEPLCVV 368
Cdd:cd00200 187 PDGEKLLSSSSDGT---IKLWDLSTGKCLGTLrgheNGVN------SVAFSPDGYLLASGSEDGTIrVWDLRTGECVQTL 257

                       330       340
                ....*....|....*....|....*..
gi 6323534  369 GNiHYSPITDLAWSEDGSTLLISSTDG 395
Cdd:cd00200 258 SG-HTNSVTSLAWSPDGKRLASGSADG 283
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
13-214 1.01e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.76  E-value: 1.01e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534   13 SQPVYSLTFqknSANDK-LFTAGGDNKVRIWKLNRDEngqnggvrkiesldFLGSLTHHEQAINVIRFNSKGDVLASAGD 91
Cdd:COG2319 204 TGAVRSVAF---SPDGKlLASGSADGTVRLWDLATGK--------------LLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534   92 DGQVLLWkqedpntqqesvvrpfgmDAETSEadenkekwvVWKRLRGGSGAtaaaeIYDLAWSPDNRNIVVACMDNSIRL 171
Cdd:COG2319 267 DGTVRLW------------------DLATGE---------LLRTLTGHSGG-----VNSVAFSPDGKLLASGSDDGTVRL 314

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 6323534  172 FDVGAGMLVCGQSDHGHYVQGVAWDPLNQFILSQSADRSLHVY 214
Cdd:COG2319 315 WDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-214 1.62e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.32  E-value: 1.62e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534    4 SHLQIYWHDSqPVYSLTFqkNSANDKLFTAGGDNKVRIWKLNRDEN-----GQNGGVRKI-------------------- 58
Cdd:cd00200   1 LRRTLKGHTG-GVTCVAF--SPDGKLLATGSGDGTIKVWDLETGELlrtlkGHTGPVRDVaasadgtylasgssdktirl 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534   59 ---ESLDFLGSLTHHEQAINVIRFNSKGDVLASAGDDGQVLLWKQEDPNTQQE---------SV-VRPFGMDAETSEADe 125
Cdd:cd00200  78 wdlETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTlrghtdwvnSVaFSPDGTFVASSSQD- 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534  126 NKEKwvVWkRLRGGSG-ATAAA---EIYDLAWSPDNRNIVVACMDNSIRLFDVGAGMLVCGQSDHGHYVQGVAWDPLNQF 201
Cdd:cd00200 157 GTIK--LW-DLRTGKCvATLTGhtgEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL 233

                       250
                ....*....|...
gi 6323534  202 ILSQSADRSLHVY 214
Cdd:cd00200 234 LASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 70-395 2.72e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.97  E-value: 2.72e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534   70 HEQAINVIRFNSKGDVLASAGDDGQVLLWKQEDPNTQqesvvrpfgmdaetseadenkekwvvwKRLRGGSGataaaEIY 149
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELL---------------------------RTLKGHTG-----PVR 55

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534  150 DLAWSPDNRNIVVACMDNSIRLFDVGAGMLVCGQSDHGHYVQGVAWDPLNQFILSQSADRSLHVYGVIlssagvvTGlkl 229
Cdd:cd00200  56 DVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE-------TG--- 125

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534  230 rskiakaelpcpgdVLRTNYLFHNETLPSffrrCSISPCGGLVVIPSG-----VYKVAG-----------DEVaNCVYVY 293
Cdd:cd00200 126 --------------KCLTTLRGHTDWVNS----VAFSPDGTFVASSSQdgtikLWDLRTgkcvatltghtGEV-NSVAFS 186

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534  294 TRSGILNSAGGVKNrpaIRIPSLKKPALMAAF----SPVFyetcqkSVLKLPYKLVFAIATTNEVL-VYDTDVLEPLCVV 368
Cdd:cd00200 187 PDGEKLLSSSSDGT---IKLWDLSTGKCLGTLrgheNGVN------SVAFSPDGYLLASGSEDGTIrVWDLRTGECVQTL 257

                       330       340
                ....*....|....*....|....*..
gi 6323534  369 GNiHYSPITDLAWSEDGSTLLISSTDG 395
Cdd:cd00200 258 SG-HTNSVTSLAWSPDGKRLASGSADG 283
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 133-180 4.98e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 44.58  E-value: 4.98e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 6323534    133 WKRLRGGSGATAAAEIYDLAWSPDNRNIVVACMDNSIRLFDVGAGMLV 180
Cdd:pfam12894  26 WQRVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV 73
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 60-99 1.10e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 1.10e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 6323534      60 SLDFLGSLTHHEQAINVIRFNSKGDVLASAGDDGQVLLWK 99
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
13-214 1.01e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 105.76  E-value: 1.01e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534   13 SQPVYSLTFqknSANDK-LFTAGGDNKVRIWKLNRDEngqnggvrkiesldFLGSLTHHEQAINVIRFNSKGDVLASAGD 91
Cdd:COG2319 204 TGAVRSVAF---SPDGKlLASGSADGTVRLWDLATGK--------------LLRTLTGHSGSVRSVAFSPDGRLLASGSA 266

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534   92 DGQVLLWkqedpntqqesvvrpfgmDAETSEadenkekwvVWKRLRGGSGAtaaaeIYDLAWSPDNRNIVVACMDNSIRL 171
Cdd:COG2319 267 DGTVRLW------------------DLATGE---------LLRTLTGHSGG-----VNSVAFSPDGKLLASGSDDGTVRL 314

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 6323534  172 FDVGAGMLVCGQSDHGHYVQGVAWDPLNQFILSQSADRSLHVY 214
Cdd:COG2319 315 WDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
5-395 4.16e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.84  E-value: 4.16e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534    5 HLQIYWHDSQPVYSLTFqknSANDK-LFTAGGDNKVRIWKLnrdENGQnggvrkiesldFLGSLTHHEQAINVIRFNSKG 83
Cdd:COG2319 112 LLRTLTGHTGAVRSVAF---SPDGKtLASGSADGTVRLWDL---ATGK-----------LLRTLTGHSGAVTSVAFSPDG 174

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534   84 DVLASAGDDGQVLLWkqedpntqqesvvrpfgmDAETSEadenkekwvVWKRLRGGSGAtaaaeIYDLAWSPDNRNIVVA 163
Cdd:COG2319 175 KLLASGSDDGTVRLW------------------DLATGK---------LLRTLTGHTGA-----VRSVAFSPDGKLLASG 222

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534  164 CMDNSIRLFDVGAGMLVCGQSDHGHYVQGVAWDPLNQFILSQSADRSLHVYgvilssaGVVTGLKLRSKiakaelpcpgd 243
Cdd:COG2319 223 SADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW-------DLATGELLRTL----------- 284

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534  244 vlrtnylfhnETLPSFFRRCSISPCGGLVVIPSG-----VYKVAGDEVancvyVYTRSGILNSAGGVknrpairipslkk 318
Cdd:COG2319 285 ----------TGHSGGVNSVAFSPDGKLLASGSDdgtvrLWDLATGKL-----LRTLTGHTGAVRSV------------- 336

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6323534  319 palmaAFSPVFyetcqksvlklpyKLVFAIATTNEVLVYDTDVLEPLCVVGNiHYSPITDLAWSEDGSTLLISSTDG 395
Cdd:COG2319 337 -----AFSPDG-------------KTLASGSDDGTVRLWDLATGELLRTLTG-HTGAVTSVAFSPDGRTLASGSADG 394
WD40 COG2319
WD40 repeat [General function prediction only];
6-216 1.07e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.90  E-value: 1.07e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534    6 LQIYWHDSQPVYSLTFqknSANDK-LFTAGGDNKVRIWKLNRDEngqnggvrkiesldFLGSLTHHEQAINVIRFNSKGD 84
Cdd:COG2319 239 LRTLTGHSGSVRSVAF---SPDGRlLASGSADGTVRLWDLATGE--------------LLRTLTGHSGGVNSVAFSPDGK 301

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534   85 VLASAGDDGQVLLWkqedpntqqesvvrpfgmDAETseadenkekwvvWKRLRGGSGATAAaeIYDLAWSPDNRNIVVAC 164
Cdd:COG2319 302 LLASGSDDGTVRLW------------------DLAT------------GKLLRTLTGHTGA--VRSVAFSPDGKTLASGS 349

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 6323534  165 MDNSIRLFDVGAGMLVCGQSDHGHYVQGVAWDPLNQFILSQSADRSLHVYGV 216
Cdd:COG2319 350 DDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-214 1.62e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.32  E-value: 1.62e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534    4 SHLQIYWHDSqPVYSLTFqkNSANDKLFTAGGDNKVRIWKLNRDEN-----GQNGGVRKI-------------------- 58
Cdd:cd00200   1 LRRTLKGHTG-GVTCVAF--SPDGKLLATGSGDGTIKVWDLETGELlrtlkGHTGPVRDVaasadgtylasgssdktirl 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534   59 ---ESLDFLGSLTHHEQAINVIRFNSKGDVLASAGDDGQVLLWKQEDPNTQQE---------SV-VRPFGMDAETSEADe 125
Cdd:cd00200  78 wdlETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTlrghtdwvnSVaFSPDGTFVASSSQD- 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534  126 NKEKwvVWkRLRGGSG-ATAAA---EIYDLAWSPDNRNIVVACMDNSIRLFDVGAGMLVCGQSDHGHYVQGVAWDPLNQF 201
Cdd:cd00200 157 GTIK--LW-DLRTGKCvATLTGhtgEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL 233

                       250
                ....*....|...
gi 6323534  202 ILSQSADRSLHVY 214
Cdd:cd00200 234 LASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-214 1.12e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.38  E-value: 1.12e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534   13 SQPVYSLTFqknSANDKLFTAGG-DNKVRIWKlnrdengqnggvrkIESLDFLGSLTHHEQAINVIRFNSKGDVLASAGD 91
Cdd:cd00200  93 TSYVSSVAF---SPDGRILSSSSrDKTIKVWD--------------VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQ 155

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534   92 DGQVLLWkqedpNTQQESVVRPFG---MDAETSEADENKEKWV---------VWKRLRGGSGATAAA---EIYDLAWSPD 156
Cdd:cd00200 156 DGTIKLW-----DLRTGKCVATLTghtGEVNSVAFSPDGEKLLssssdgtikLWDLSTGKCLGTLRGhenGVNSVAFSPD 230

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6323534  157 NRNIVVACMDNSIRLFDVGAGMLVCGQSDHGHYVQGVAWDPLNQFILSQSADRSLHVY 214
Cdd:cd00200 231 GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 70-395 2.72e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.97  E-value: 2.72e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534   70 HEQAINVIRFNSKGDVLASAGDDGQVLLWKQEDPNTQqesvvrpfgmdaetseadenkekwvvwKRLRGGSGataaaEIY 149
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELL---------------------------RTLKGHTG-----PVR 55

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534  150 DLAWSPDNRNIVVACMDNSIRLFDVGAGMLVCGQSDHGHYVQGVAWDPLNQFILSQSADRSLHVYGVIlssagvvTGlkl 229
Cdd:cd00200  56 DVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE-------TG--- 125

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534  230 rskiakaelpcpgdVLRTNYLFHNETLPSffrrCSISPCGGLVVIPSG-----VYKVAG-----------DEVaNCVYVY 293
Cdd:cd00200 126 --------------KCLTTLRGHTDWVNS----VAFSPDGTFVASSSQdgtikLWDLRTgkcvatltghtGEV-NSVAFS 186

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534  294 TRSGILNSAGGVKNrpaIRIPSLKKPALMAAF----SPVFyetcqkSVLKLPYKLVFAIATTNEVL-VYDTDVLEPLCVV 368
Cdd:cd00200 187 PDGEKLLSSSSDGT---IKLWDLSTGKCLGTLrgheNGVN------SVAFSPDGYLLASGSEDGTIrVWDLRTGECVQTL 257

                       330       340
                ....*....|....*....|....*..
gi 6323534  369 GNiHYSPITDLAWSEDGSTLLISSTDG 395
Cdd:cd00200 258 SG-HTNSVTSLAWSPDGKRLASGSADG 283
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-173 1.29e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.05  E-value: 1.29e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534   11 HDSqPVYSLTFQKNsaNDKLFTAGGDNKVRIWKLNrdengqnggvrkieSLDFLGSLTHHEQAINVIRFNSKGDVLASAG 90
Cdd:cd00200 176 HTG-EVNSVAFSPD--GEKLLSSSSDGTIKLWDLS--------------TGKCLGTLRGHENGVNSVAFSPDGYLLASGS 238

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534   91 DDGQVLLWkqedpntqqesvvrpfgmdaetseadeNKEKWVVWKRLRGGSGAtaaaeIYDLAWSPDNRNIVVACMDNSIR 170
Cdd:cd00200 239 EDGTIRVW---------------------------DLRTGECVQTLSGHTNS-----VTSLAWSPDGKRLASGSADGTIR 286


                ...
gi 6323534  171 LFD 173
Cdd:cd00200 287 IWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
84-214 2.54e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.69  E-value: 2.54e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534   84 DVLASAGDDGQVLLWKQEDPNTQQESVVRPFGMDAETSEADENKEKWVVWKRLRGGSGATAAAEIYDLAWSPDNRNIVVA 163
Cdd:COG2319  17 ALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASA 96

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 6323534  164 CMDNSIRLFDVGAGMLVCGQSDHGHYVQGVAWDPLNQFILSQSADRSLHVY 214
Cdd:COG2319  97 SADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW 147
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 146-410 1.97e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.34  E-value: 1.97e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534  146 AEIYDLAWSPDNRNIVVACMDNSIRLFDVGAGMLVCGQSDHGHYVQGVAWDPLNQFILSQSADRSLHVYgvilssagvvt 225
Cdd:cd00200  10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLW----------- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534  226 glKLRSkiakaelpcpGDVLRTnYLFHNETLPSffrrCSISPCGGLVVIPSGVYKVAGDEVANCVYVYTRSGIlnsaggv 305
Cdd:cd00200  79 --DLET----------GECVRT-LTGHTSYVSS----VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH------- 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534  306 knrpairipslKKPALMAAFSPvfyetcqksvlklPYKLVFAIATTNEVLVYDTDVLEpLCVVGNIHYSPITDLAWSEDG 385
Cdd:cd00200 135 -----------TDWVNSVAFSP-------------DGTFVASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSPDG 189

                       250       260
                ....*....|....*....|....*
gi 6323534  386 STLLISSTDGFCSYVSIDTETQFGS 410
Cdd:cd00200 190 EKLLSSSSDGTIKLWDLSTGKCLGT 214
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-99 8.69e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.41  E-value: 8.69e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534    4 SHLQIYWHDSQPVYSLTFqknSANDKLFTAGG-DNKVRIWKLnrdengqnggvrkiESLDFLGSLTHHEQAINVIRFNSK 82
Cdd:cd00200 210 KCLGTLRGHENGVNSVAF---SPDGYLLASGSeDGTIRVWDL--------------RTGECVQTLSGHTNSVTSLAWSPD 272

                        90
                ....*....|....*..
gi 6323534   83 GDVLASAGDDGQVLLWK 99
Cdd:cd00200 273 GKRLASGSADGTIRIWD 289
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 133-180 4.98e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 44.58  E-value: 4.98e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 6323534    133 WKRLRGGSGATAAAEIYDLAWSPDNRNIVVACMDNSIRLFDVGAGMLV 180
Cdd:pfam12894  26 WQRVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV 73
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 60-99 1.10e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 1.10e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 6323534      60 SLDFLGSLTHHEQAINVIRFNSKGDVLASAGDDGQVLLWK 99
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
63-98 2.34e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 2.34e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 6323534     63 FLGSLTHHEQAINVIRFNSKGDVLASAGDDGQVLLW 98
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 146-173 3.78e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 3.78e-04
                           10        20
                   ....*....|....*....|....*...
gi 6323534     146 AEIYDLAWSPDNRNIVVACMDNSIRLFD 173
Cdd:smart00320  13 GPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
146-173 1.29e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.29e-03
                          10        20
                  ....*....|....*....|....*...
gi 6323534    146 AEIYDLAWSPDNRNIVVACMDNSIRLFD 173
Cdd:pfam00400  12 GSVTSLAFSPDGKLLASGSDDGTVKVWD 39
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 142-216 1.58e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 41.18  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323534   142 ATAAAEIYDLAWSPDNRNIVVACMDNSIRLFDVGAGML-VCGQSDHGHYVQGVAWDPLNQFIL-SQSAD---RSLHVYGV 216
Cdd:COG4946  385 LGDLGRVFNPVWSPDGKKIAFTDNRGRLWVVDLASGKVrKVDTDGYGDGISDLAWSPDSKWLAySKPGPnqlSQIFLYDV 464
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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