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Conserved domains on  [gi|6323561|ref|NP_013632|]
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Cff1p [Saccharomyces cerevisiae S288C]

Protein Classification

cupin domain-containing protein( domain architecture ID 10533071)

cupin domain-containing protein, part of a functionally diverse superfamily with the active site generally located at the center of a conserved domain forming a beta-barrel fold; similar to Saccharomyces cerevisiae protein YML079W

CATH:  2.60.120.10
Gene Ontology:  GO:0046872
PubMed:  19478949|14697267|9573603
SCOP:  3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cupin_5 pfam06172
Cupin superfamily (DUF985); Family of uncharacterized proteins found in bacteria and ...
 31-178 2.98e-58

Cupin superfamily (DUF985); Family of uncharacterized proteins found in bacteria and eukaryotes that belongs to the Cupin superfamily.


:

Pssm-ID: 461843  Cd Length: 139  Bit Score: 179.64  E-value: 2.98e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323561     31 QQLINDWQLIKHREGGYFKETDRSPYTMEVEKPVNGGsgntemvTRNQSTLIYYLLTPdSPIGKFHKNINRIIHILQRGK 110
Cdd:pfam06172   1 QELIAKLGLEPHPEGGYFRETYRSPETIPSPDLDYGG-------PRSASTAIYFLLTA-GPFSAFHRVDSDEVWHFHAGA 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323561    111 G-QYVLVYP-DGQVKSFKVGFDYKNGEVSQWVVPGGVFKASFLLPNEEFdngFLISEVVVPGFDFEDHTF 178
Cdd:pfam06172  73 PlELHLIHPdDGSVETVVLGPDLAAGERPQVVVPAGVWQAARLLGDDGY---SLVSCTVAPGFDFEDFEL 139
 
Name Accession Description Interval E-value
Cupin_5 pfam06172
Cupin superfamily (DUF985); Family of uncharacterized proteins found in bacteria and ...
 31-178 2.98e-58

Cupin superfamily (DUF985); Family of uncharacterized proteins found in bacteria and eukaryotes that belongs to the Cupin superfamily.


Pssm-ID: 461843  Cd Length: 139  Bit Score: 179.64  E-value: 2.98e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323561     31 QQLINDWQLIKHREGGYFKETDRSPYTMEVEKPVNGGsgntemvTRNQSTLIYYLLTPdSPIGKFHKNINRIIHILQRGK 110
Cdd:pfam06172   1 QELIAKLGLEPHPEGGYFRETYRSPETIPSPDLDYGG-------PRSASTAIYFLLTA-GPFSAFHRVDSDEVWHFHAGA 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323561    111 G-QYVLVYP-DGQVKSFKVGFDYKNGEVSQWVVPGGVFKASFLLPNEEFdngFLISEVVVPGFDFEDHTF 178
Cdd:pfam06172  73 PlELHLIHPdDGSVETVVLGPDLAAGERPQVVVPAGVWQAARLLGDDGY---SLVSCTVAPGFDFEDFEL 139
cupin_YML079wp cd06121
Saccharomyces cerevisiae YML079wp and related proteins, cupin domain; This family includes ...
 31-186 1.87e-48

Saccharomyces cerevisiae YML079wp and related proteins, cupin domain; This family includes eukaryotic, bacterial, and archaeal proteins homologous to YML079wp, a Saccharomyces cerevisiae cupin-like protein of unknown function that structurally resembles plant seed storage and ligand-binding proteins (canavalin, glycinin, auxin binding protein) as well as the bacterial RmlC epimerase. YML079wp is non-essential in yeast and localizes to the nucleus and cytoplasm. The presence of a hydrophobic ligand within a well-conserved binding pocket inside the cupin beta-barrel and sequence similarity with bacterial epimerases suggests a possible biochemical function for YML079wp and its homologs. Also included in this family are Shewanella oneidensis So0799, Agrobacterium fabrum Atu3615 and Branchiostoma belcheri Bbduf985. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold and forms a homodimer.


Pssm-ID: 380376  Cd Length: 153  Bit Score: 155.01  E-value: 1.87e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323561   31 QQLINDWQLIKHREGGYFKETDRSPYTmeVEKPVNGGsgntemvTRNQSTLIYYLLTPDsPIGKFHKNINRIIHILQRGK 110
Cdd:cd06121   2 EELIEKLGLEPHPEGGYFRETYRSPET--VPTPRDGG-------ERPASTAIYYLLTPG-DFSAFHRLKSDEIWHFHAGD 71

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6323561  111 G-QYVLVYPDGQVKSFKVGFDYKNGEVSQWVVPGGVFKASFLLPNEEFdngFLISEVVVPGFDFEDHTFLKGEDELK 186
Cdd:cd06121  72 PlELHLLDPDGTYETVVLGPDLAAGERPQVVVPAGTWQAAELLGGGGY---ALVGCTVAPGFDFEDFELGDREELLA 145
CFF1 COG3542
Predicted sugar epimerase, cupin superfamily [General function prediction only];
31-186 5.33e-33

Predicted sugar epimerase, cupin superfamily [General function prediction only];


Pssm-ID: 442763  Cd Length: 149  Bit Score: 115.66  E-value: 5.33e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323561   31 QQLINDWQLIKHREGGYFKETDRSPYTmeVEKPVNGGSgntemvtRNQSTLIYYLLTPDSPiGKFHKNINRIIHILQRGK 110
Cdd:COG3542   6 EELIEKLGLEPHPEGGYYRETYRSAER--IPAAALGGG-------RAASTAIYFLLTAGEF-SHWHRVDSDEIWHFYAGD 75

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6323561  111 G-QYVLVYPDGQVKSFKVGFDYKNGEVSQWVVPGGVFKASFLLPNEEFdngFLISEVVVPGFDFEDHTFLKGEDELK 186
Cdd:COG3542  76 PlELHLIHPDGTYETVVLGPDLAAGQRPQLVVPAGTWQAARLLGGGGY---ALVGCTVAPGFDFEDFELAPRDELLA 149
 
Name Accession Description Interval E-value
Cupin_5 pfam06172
Cupin superfamily (DUF985); Family of uncharacterized proteins found in bacteria and ...
 31-178 2.98e-58

Cupin superfamily (DUF985); Family of uncharacterized proteins found in bacteria and eukaryotes that belongs to the Cupin superfamily.


Pssm-ID: 461843  Cd Length: 139  Bit Score: 179.64  E-value: 2.98e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323561     31 QQLINDWQLIKHREGGYFKETDRSPYTMEVEKPVNGGsgntemvTRNQSTLIYYLLTPdSPIGKFHKNINRIIHILQRGK 110
Cdd:pfam06172   1 QELIAKLGLEPHPEGGYFRETYRSPETIPSPDLDYGG-------PRSASTAIYFLLTA-GPFSAFHRVDSDEVWHFHAGA 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323561    111 G-QYVLVYP-DGQVKSFKVGFDYKNGEVSQWVVPGGVFKASFLLPNEEFdngFLISEVVVPGFDFEDHTF 178
Cdd:pfam06172  73 PlELHLIHPdDGSVETVVLGPDLAAGERPQVVVPAGVWQAARLLGDDGY---SLVSCTVAPGFDFEDFEL 139
cupin_YML079wp cd06121
Saccharomyces cerevisiae YML079wp and related proteins, cupin domain; This family includes ...
 31-186 1.87e-48

Saccharomyces cerevisiae YML079wp and related proteins, cupin domain; This family includes eukaryotic, bacterial, and archaeal proteins homologous to YML079wp, a Saccharomyces cerevisiae cupin-like protein of unknown function that structurally resembles plant seed storage and ligand-binding proteins (canavalin, glycinin, auxin binding protein) as well as the bacterial RmlC epimerase. YML079wp is non-essential in yeast and localizes to the nucleus and cytoplasm. The presence of a hydrophobic ligand within a well-conserved binding pocket inside the cupin beta-barrel and sequence similarity with bacterial epimerases suggests a possible biochemical function for YML079wp and its homologs. Also included in this family are Shewanella oneidensis So0799, Agrobacterium fabrum Atu3615 and Branchiostoma belcheri Bbduf985. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold and forms a homodimer.


Pssm-ID: 380376  Cd Length: 153  Bit Score: 155.01  E-value: 1.87e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323561   31 QQLINDWQLIKHREGGYFKETDRSPYTmeVEKPVNGGsgntemvTRNQSTLIYYLLTPDsPIGKFHKNINRIIHILQRGK 110
Cdd:cd06121   2 EELIEKLGLEPHPEGGYFRETYRSPET--VPTPRDGG-------ERPASTAIYYLLTPG-DFSAFHRLKSDEIWHFHAGD 71

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6323561  111 G-QYVLVYPDGQVKSFKVGFDYKNGEVSQWVVPGGVFKASFLLPNEEFdngFLISEVVVPGFDFEDHTFLKGEDELK 186
Cdd:cd06121  72 PlELHLLDPDGTYETVVLGPDLAAGERPQVVVPAGTWQAAELLGGGGY---ALVGCTVAPGFDFEDFELGDREELLA 145
CFF1 COG3542
Predicted sugar epimerase, cupin superfamily [General function prediction only];
31-186 5.33e-33

Predicted sugar epimerase, cupin superfamily [General function prediction only];


Pssm-ID: 442763  Cd Length: 149  Bit Score: 115.66  E-value: 5.33e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323561   31 QQLINDWQLIKHREGGYFKETDRSPYTmeVEKPVNGGSgntemvtRNQSTLIYYLLTPDSPiGKFHKNINRIIHILQRGK 110
Cdd:COG3542   6 EELIEKLGLEPHPEGGYYRETYRSAER--IPAAALGGG-------RAASTAIYFLLTAGEF-SHWHRVDSDEIWHFYAGD 75

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6323561  111 G-QYVLVYPDGQVKSFKVGFDYKNGEVSQWVVPGGVFKASFLLPNEEFdngFLISEVVVPGFDFEDHTFLKGEDELK 186
Cdd:COG3542  76 PlELHLIHPDGTYETVVLGPDLAAGQRPQLVVPAGTWQAARLLGGGGY---ALVGCTVAPGFDFEDFELAPRDELLA 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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