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Conserved domains on  [gi|6323606|ref|NP_013677|]
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AMP deaminase [Saccharomyces cerevisiae S288C]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AMP_deaminase pfam19326
AMP deaminase;
160-803 0e+00

AMP deaminase;


:

Pssm-ID: 437158 [Multi-domain]  Cd Length: 622  Bit Score: 1062.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    160 KQVRTSASYKMGMLADDasqqflddpsseLIDLYSKVAECRNLRAKYQTI--------SVQNDDQNPKNKPGWVVYPPPP 231
Cdd:pfam19326   4 QRVTISGDYKLGVPTED------------LEEAYKSLAECLEIREKYMFPettapylkSVQGEDSTPKENDEPVFHPPPK 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    232 KpsynsdtktvvpvtNKPDAEVFDFTkceipgedPDWEFTLNDDDSyVVHRSGKTDELI--AQIPTLRDYYLDLEKMISI 309
Cdd:pfam19326  72 K--------------GEDPYELFNFP--------PDLGYHLRMQDG-VVHVYANKDALEdsLPYPDLRDFYTDLEHLLAL 128
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    310 SSDGPAKSFAYRRLQYLEARWNLYYLLNEYQETSVSKRNPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKHKLRHSKDEK 389
Cdd:pfam19326 129 IADGPIKTFCHRRLQYLESKFNLHLMLNEMKELKAQKSNPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKSKLRKEPDEV 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    390 VIFRDGKLLTLDEVFRSLHLTGYDLSIDTLDMHAHKDTFHRFDKFNLKYNPIGESRLREIFLKTNNYIKGTYLADITKQV 469
Cdd:pfam19326 209 VIFRDGKYLTLREVFESLKLTGYDLSVDTLDVHADRDTFHRFDKFNLKYNPIGESRLREIFLKTDNYINGRYLAEITKEV 288
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    470 IFDLENSKYQNCEYRISVYGRSLDEWDKLASWVIDNKVISHNVRWLVQIPRLYDIYKKTGIVQSFQDICKNLFQPLFEVT 549
Cdd:pfam19326 289 FSDLEESKYQMAEYRISIYGRSPDEWDKLASWIVDNKVYSPNVRWLIQVPRLYDIYKKKGIVPSFQKMLENIFLPLFEAT 368
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    550 KNPQSHPKLHVFLQRVIGFDSVDDESKVDRRFHRKYPKPSLWEAPQNPPYSYYLYYLYSNVASLNQWRAKRGFNTLVLRP 629
Cdd:pfam19326 369 VNPQSHPELHVFLKRVIGFDSVDDESKPERRMFRKSPKPALWTNEQNPPYSYYLYYMYANIAVLNSLRKERGFNTFVLRP 448
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    630 HCGEAGDPEHLVSAYLLAHGISHGILLRKVPFVQYLYYLDQVGIAMSPLSNNALFLTYDKNPFPRYFKRGLNVSLSTDDP 709
Cdd:pfam19326 449 HCGEAGDIDHLVSAFLLAHGISHGILLRKSPVLQYLYYLAQIGIAMSPLSNNSLFLEYHKNPFPEFFKRGLNVSLSTDDP 528
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    710 LQFSYTREPLIEEYSVAAQIYKLSNVDMCELARNSVLQSGWEAQIKKHWIGKDFDKSGVEGNDVVRTNVPDIRINYRYDT 789
Cdd:pfam19326 529 LQFHFTKEPLMEEYSIAAQVWKLSACDMCELARNSVLQSGFSHQLKSHWLGKDYYKEGPEGNDIRRTNVPDIRVAYRYET 608
                         650
                  ....*....|....
gi 6323606    790 LSTELELVNHFANF 803
Cdd:pfam19326 609 LCQELALISDAVKS 622
 
Name Accession Description Interval E-value
AMP_deaminase pfam19326
AMP deaminase;
160-803 0e+00

AMP deaminase;


Pssm-ID: 437158 [Multi-domain]  Cd Length: 622  Bit Score: 1062.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    160 KQVRTSASYKMGMLADDasqqflddpsseLIDLYSKVAECRNLRAKYQTI--------SVQNDDQNPKNKPGWVVYPPPP 231
Cdd:pfam19326   4 QRVTISGDYKLGVPTED------------LEEAYKSLAECLEIREKYMFPettapylkSVQGEDSTPKENDEPVFHPPPK 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    232 KpsynsdtktvvpvtNKPDAEVFDFTkceipgedPDWEFTLNDDDSyVVHRSGKTDELI--AQIPTLRDYYLDLEKMISI 309
Cdd:pfam19326  72 K--------------GEDPYELFNFP--------PDLGYHLRMQDG-VVHVYANKDALEdsLPYPDLRDFYTDLEHLLAL 128
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    310 SSDGPAKSFAYRRLQYLEARWNLYYLLNEYQETSVSKRNPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKHKLRHSKDEK 389
Cdd:pfam19326 129 IADGPIKTFCHRRLQYLESKFNLHLMLNEMKELKAQKSNPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKSKLRKEPDEV 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    390 VIFRDGKLLTLDEVFRSLHLTGYDLSIDTLDMHAHKDTFHRFDKFNLKYNPIGESRLREIFLKTNNYIKGTYLADITKQV 469
Cdd:pfam19326 209 VIFRDGKYLTLREVFESLKLTGYDLSVDTLDVHADRDTFHRFDKFNLKYNPIGESRLREIFLKTDNYINGRYLAEITKEV 288
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    470 IFDLENSKYQNCEYRISVYGRSLDEWDKLASWVIDNKVISHNVRWLVQIPRLYDIYKKTGIVQSFQDICKNLFQPLFEVT 549
Cdd:pfam19326 289 FSDLEESKYQMAEYRISIYGRSPDEWDKLASWIVDNKVYSPNVRWLIQVPRLYDIYKKKGIVPSFQKMLENIFLPLFEAT 368
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    550 KNPQSHPKLHVFLQRVIGFDSVDDESKVDRRFHRKYPKPSLWEAPQNPPYSYYLYYLYSNVASLNQWRAKRGFNTLVLRP 629
Cdd:pfam19326 369 VNPQSHPELHVFLKRVIGFDSVDDESKPERRMFRKSPKPALWTNEQNPPYSYYLYYMYANIAVLNSLRKERGFNTFVLRP 448
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    630 HCGEAGDPEHLVSAYLLAHGISHGILLRKVPFVQYLYYLDQVGIAMSPLSNNALFLTYDKNPFPRYFKRGLNVSLSTDDP 709
Cdd:pfam19326 449 HCGEAGDIDHLVSAFLLAHGISHGILLRKSPVLQYLYYLAQIGIAMSPLSNNSLFLEYHKNPFPEFFKRGLNVSLSTDDP 528
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    710 LQFSYTREPLIEEYSVAAQIYKLSNVDMCELARNSVLQSGWEAQIKKHWIGKDFDKSGVEGNDVVRTNVPDIRINYRYDT 789
Cdd:pfam19326 529 LQFHFTKEPLMEEYSIAAQVWKLSACDMCELARNSVLQSGFSHQLKSHWLGKDYYKEGPEGNDIRRTNVPDIRVAYRYET 608
                         650
                  ....*....|....
gi 6323606    790 LSTELELVNHFANF 803
Cdd:pfam19326 609 LCQELALISDAVKS 622
AMPD cd01319
AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at ...
299-794 0e+00

AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.


Pssm-ID: 238644  Cd Length: 496  Bit Score: 940.25  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606  299 YYLDLEKMISISSDGPAKSFAYRRLQYLEARWNLYYLLNEYQETSVSKRNPHRDFYNVRKVDTHVHHSACMNQKHLLRFI 378
Cdd:cd01319   1 FYLDLEFLLALISDGPAKSFCYRRLQYLESKFQLHVLLNEDRELKEQKTVPHRDFYNVRKVDTHVHHSACMNQKHLLRFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606  379 KHKLRHSKDEKVIFRDGKLLTLDEVFRSLHLTGYDLSIDTLDMHAHKDTFHRFDKFNLKYNPIGESRLREIFLKTNNYIK 458
Cdd:cd01319  81 KKKLRTEPDEVVIFRDGKKLTLKEVFDSLKLTAYDLSVDTLDVHADRNTFHRFDKFNLKYNPIGESRLREIFLKTDNYIN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606  459 GTYLADITKQVIFDLENSKYQNCEYRISVYGRSLDEWDKLASWVIDNKVISHNVRWLVQIPRLYDIYKKTGIVQSFQDIC 538
Cdd:cd01319 161 GRYLAEITKEVFSDLEESKYQHAEYRLSIYGRSKDEWDKLASWVVDNDLFSPNVRWLIQIPRLYDVYKKSGIVNSFQEML 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606  539 KNLFQPLFEVTKNPQSHPKLHVFLQRVIGFDSVDDESKVDRRFHRKYPKPSLWEAPQNPPYSYYLYYLYSNVASLNQWRA 618
Cdd:cd01319 241 ENIFEPLFEATKDPSSHPELHVFLQQVIGFDSVDDESKSERRFTRKFPKPEEWTSEENPPYSYYLYYMYANITTLNSFRK 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606  619 KRGFNTLVLRPHCGEAGDPEHLVSAYLLAHGISHGILLRKVPFVQYLYYLDQVGIAMSPLSNNALFLTYDKNPFPRYFKR 698
Cdd:cd01319 321 ARGFNTFVLRPHCGEAGDIDHLASAFLLAHGISHGINLRKVPVLQYLYYLTQIGIAMSPLSNNSLFLSYEKNPFPEFFKR 400
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606  699 GLNVSLSTDDPLQFSYTREPLIEEYSVAAQIYKLSNVDMCELARNSVLQSGWEAQIKKHWIGKDFDKSGVEGNDVVRTNV 778
Cdd:cd01319 401 GLNVSLSTDDPLQFHFTKEPLMEEYSIAAQVWKLSTCDMCELARNSVLQSGFEHSIKRHWLGPNYLKRGVAGNDIRRTNV 480
                       490
                ....*....|....*.
gi 6323606  779 PDIRINYRYDTLSTEL 794
Cdd:cd01319 481 PQIRMAYRYETLCEEL 496
AMP_deaminase TIGR01429
AMP deaminase; This model describes AMP deaminase, a large, well-conserved eukaryotic protein ...
188-797 0e+00

AMP deaminase; This model describes AMP deaminase, a large, well-conserved eukaryotic protein involved in energy metabolism. Most members of the family have an additional, poorly alignable region of 150 amino acids or more N-terminal to the region included in the model.


Pssm-ID: 273618 [Multi-domain]  Cd Length: 611  Bit Score: 837.19  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    188 ELIDLYSKVAECRNLRAKYQTISVQNDDQNPKNKPGWvvypPPPKPSYNSDTKTVVPVTNKPDAEVFDFTKCEIPGEDPD 267
Cdd:TIGR01429   2 DLAEAAKSLAKALMLREKYARLAYHRFPDTTAQYLSH----QGYPESVPLEEGLPDFHPPPDPQEDPYCLDDDAPPIELG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    268 WEFTLNDDDSYVVHRSGKTDELIAQI---PTLRDYYLDLEKMISISSDGPAKSFAYRRLQYLEARWNLYYLLNEYQETSV 344
Cdd:TIGR01429  78 YLVRMHGGVLFVYDNDTMLERQEPHFlvpPTLETYYVDMEHLLALISDGPTKSFCFRRLQYLESKFNLHELLNEMSELKE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    345 SKRNPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKHKLRHSKDEKVIFRDGKLLTLDEVFRSLHLTGYDLSIDTLDMHAH 424
Cdd:TIGR01429 158 QKSVPHRDFYNVRKVDTHIHAAASMNQKHLLRFIKHKLKTEPDETVIERDGKKLTLREVFDSLHLDPYDLSVDTLDVHAD 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    425 KDTFHRFDKFNLKYNPIGESRLREIFLKTNNYIKGTYLADITKQVIFDLENSKYQNCEYRISVYGRSLDEWDKLASWVID 504
Cdd:TIGR01429 238 RNTFHRFDKFNLKYNPVGESRLREIFLKTDNYIGGKYFAELVKEVFTDLEDSKYQYAEPRLSIYGRSPKEWDSLARWIID 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    505 NKVISHNVRWLVQIPRLYDIYKKTGIVQSFQDICKNLFQPLFEVTKNPQSHPKLHVFLQRVIGFDSVDDESK-VDRRFHR 583
Cdd:TIGR01429 318 HDVFSPNVRWLIQVPRLYDVYRSKKLVPNFGDMLENVFLPLFEVTKDPSSHPELHLFLQQVTGFDSVDDESKhEDHMFSR 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    584 KYPKPSLWEAPQNPPYSYYLYYLYSNVASLNQWRAKRGFNTLVLRPHCGEAGDPEHLVSAYLLAHGISHGILLRKVPFVQ 663
Cdd:TIGR01429 398 KFPSPDEWTSEQNPPYSYYLYYMYANIMVLNNFRRERGLNTFLLRPHCGEAGSVDHLVSAFLTSHGINHGILLRKVPVLQ 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    664 YLYYLDQVGIAMSPLSNNALFLTYDKNPFPRYFKRGLNVSLSTDDPLQFSYTREPLIEEYSVAAQIYKLSNVDMCELARN 743
Cdd:TIGR01429 478 YLYYLTQIPIAMSPLSNNSLFLEYSKNPLPEYLHKGLNVSLSTDDPLQFHYTKEALMEEYAIAAQVWKLSTCDMCELARN 557
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....
gi 6323606    744 SVLQSGWEAQIKKHWIGKDFDKSGVEGNDVVRTNVPDIRINYRYDTLSTELELV 797
Cdd:TIGR01429 558 SVLQSGFEHQVKQHWLGPNYYKEGPEGNDIRRTNVPDIRVAFRYETLCNELSLL 611
PLN03055 PLN03055
AMP deaminase; Provisional
183-797 0e+00

AMP deaminase; Provisional


Pssm-ID: 178613  Cd Length: 602  Bit Score: 722.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606   183 DDPSSELIDLYSKVAECRNLRAKYqtisvqnddqnpknkpgwvVYPPPPKPSYNSDTKtvvPVTNKPDAEVFDFTkceiP 262
Cdd:PLN03055   2 DAPSDEEEEVCAMMQECLELRDKY-------------------LFREKLPPWRKGIFE---SSTSKPNPDPFRYE----P 55
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606   263 GEDPDWEFTLNDDDSYVVHRSGKTDELIaQIPTLRDYYLDLEKMISISSDGPAKSFAYRRLQYLEARWNLYYLLNEYQET 342
Cdd:PLN03055  56 EPPSQHVFRMVDGVMHVYAPDDAKEELF-PVPDATTFFTDMHRILRIVSLGNVRTFCHHRLKLLEQKFSLHLMLNADREF 134
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606   343 SVSKRNPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKHKLRHSKDEKVIFRDGKLLTLDEVFRSLHLTGYDLSIDTLDMH 422
Cdd:PLN03055 135 LAQKSAPHRDFYNVRKVDTHVHHSSCMNQKHLLRFIKSKLRKEPDEVVIFRDGKYLTLREVFESLDLTGYDLNVDLLDVH 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606   423 AHKDTFHRFDKFNLKYNPIGESRLREIFLKTNNYIKGTYLADITKQVIFDLENSKYQNCEYRISVYGRSLDEWDKLASWV 502
Cdd:PLN03055 215 ADKNTFHRFDKFNLKYNPCGQSRLREIFLKQDNLIQGRFLAELTKEVFSDLEASKYQMAEYRISIYGRKQSEWDQLASWI 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606   503 IDNKVISHNVRWLVQIPRLYDIYKKTGIVQSFQDICKNLFQPLFEVTKNPQSHPKLHVFLQRVIGFDSVDDESKVDRRFH 582
Cdd:PLN03055 295 VNNRLYSENVVWLIQLPRLYNVYKEMGIVQSFQQILDNIFKPLFEVTVDPSSHPQLHVFLKMVVGFDMVDDESKPERRPT 374
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606   583 RKYPKPSLWEAPQNPPYSYYLYYLYSNVASLNQWRAKRGFNTLVLRPHCGEAGDPEHLVSAYLLAHGISHGILLRKVPFV 662
Cdd:PLN03055 375 KHMQTPEQWDIPFNPAYSYWAYYVYANLYTLNKLRESKGLNTIKFRPHAGEAGDIDHLAAAFLLAHNIAHGNNLRKSPGL 454
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606   663 QYLYYLDQVGIAMSPLSNNALFLTYDKNPFPRYFKRGLNVSLSTDDPLQFSYTREPLIEEYSVAAQIYKLSNVDMCELAR 742
Cdd:PLN03055 455 QYLYYLAQIGLAMSPLSNNSLFLDYHRNPFPMFFARGLNVSLSTDDPLQIHLTKEPLVEEYSIAAQVWKLSSCDLCEIAR 534
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 6323606   743 NSVLQSGWEAQIKKHWIGKDFDKSGVEGNDVVRTNVPDIRINYRYDTLSTELELV 797
Cdd:PLN03055 535 NSVLQSGFPHASKKHWVGDNYWLRGPAGNDIHKTNVPHMRVEFRHEVWKEELQYV 589
Add COG1816
Adenosine deaminase [Nucleotide transport and metabolism]; Adenosine deaminase is part of the ...
629-759 3.41e-16

Adenosine deaminase [Nucleotide transport and metabolism]; Adenosine deaminase is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 441421  Cd Length: 326  Bit Score: 80.51  E-value: 3.41e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606  629 PHCGEAGDPEHLVSA--YLLAHGISHGI-LLRKVPFVQYLyyLD-QVGIAMSPLSNNAL--FLTYDKNPFPRYFKRGLNV 702
Cdd:COG1816 186 AHAGEAGGPESIWEAldLLGAERIGHGVrAIEDPALVARL--ADrGIPLEVCPTSNVQLgvVPSLAEHPLRRLLDAGVRV 263
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6323606  703 SLSTDDPLQFSYTrepLIEEYSVAAQIYKLSNVDMCELARNSVLQSGWEAQIKKHWI 759
Cdd:COG1816 264 TLNTDDPLYFGTT---LTDEYELAAEAFGLSDADLAQLARNAIEASFLPEEEKAALL 317
 
Name Accession Description Interval E-value
AMP_deaminase pfam19326
AMP deaminase;
160-803 0e+00

AMP deaminase;


Pssm-ID: 437158 [Multi-domain]  Cd Length: 622  Bit Score: 1062.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    160 KQVRTSASYKMGMLADDasqqflddpsseLIDLYSKVAECRNLRAKYQTI--------SVQNDDQNPKNKPGWVVYPPPP 231
Cdd:pfam19326   4 QRVTISGDYKLGVPTED------------LEEAYKSLAECLEIREKYMFPettapylkSVQGEDSTPKENDEPVFHPPPK 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    232 KpsynsdtktvvpvtNKPDAEVFDFTkceipgedPDWEFTLNDDDSyVVHRSGKTDELI--AQIPTLRDYYLDLEKMISI 309
Cdd:pfam19326  72 K--------------GEDPYELFNFP--------PDLGYHLRMQDG-VVHVYANKDALEdsLPYPDLRDFYTDLEHLLAL 128
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    310 SSDGPAKSFAYRRLQYLEARWNLYYLLNEYQETSVSKRNPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKHKLRHSKDEK 389
Cdd:pfam19326 129 IADGPIKTFCHRRLQYLESKFNLHLMLNEMKELKAQKSNPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKSKLRKEPDEV 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    390 VIFRDGKLLTLDEVFRSLHLTGYDLSIDTLDMHAHKDTFHRFDKFNLKYNPIGESRLREIFLKTNNYIKGTYLADITKQV 469
Cdd:pfam19326 209 VIFRDGKYLTLREVFESLKLTGYDLSVDTLDVHADRDTFHRFDKFNLKYNPIGESRLREIFLKTDNYINGRYLAEITKEV 288
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    470 IFDLENSKYQNCEYRISVYGRSLDEWDKLASWVIDNKVISHNVRWLVQIPRLYDIYKKTGIVQSFQDICKNLFQPLFEVT 549
Cdd:pfam19326 289 FSDLEESKYQMAEYRISIYGRSPDEWDKLASWIVDNKVYSPNVRWLIQVPRLYDIYKKKGIVPSFQKMLENIFLPLFEAT 368
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    550 KNPQSHPKLHVFLQRVIGFDSVDDESKVDRRFHRKYPKPSLWEAPQNPPYSYYLYYLYSNVASLNQWRAKRGFNTLVLRP 629
Cdd:pfam19326 369 VNPQSHPELHVFLKRVIGFDSVDDESKPERRMFRKSPKPALWTNEQNPPYSYYLYYMYANIAVLNSLRKERGFNTFVLRP 448
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    630 HCGEAGDPEHLVSAYLLAHGISHGILLRKVPFVQYLYYLDQVGIAMSPLSNNALFLTYDKNPFPRYFKRGLNVSLSTDDP 709
Cdd:pfam19326 449 HCGEAGDIDHLVSAFLLAHGISHGILLRKSPVLQYLYYLAQIGIAMSPLSNNSLFLEYHKNPFPEFFKRGLNVSLSTDDP 528
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    710 LQFSYTREPLIEEYSVAAQIYKLSNVDMCELARNSVLQSGWEAQIKKHWIGKDFDKSGVEGNDVVRTNVPDIRINYRYDT 789
Cdd:pfam19326 529 LQFHFTKEPLMEEYSIAAQVWKLSACDMCELARNSVLQSGFSHQLKSHWLGKDYYKEGPEGNDIRRTNVPDIRVAYRYET 608
                         650
                  ....*....|....
gi 6323606    790 LSTELELVNHFANF 803
Cdd:pfam19326 609 LCQELALISDAVKS 622
AMPD cd01319
AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at ...
299-794 0e+00

AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.


Pssm-ID: 238644  Cd Length: 496  Bit Score: 940.25  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606  299 YYLDLEKMISISSDGPAKSFAYRRLQYLEARWNLYYLLNEYQETSVSKRNPHRDFYNVRKVDTHVHHSACMNQKHLLRFI 378
Cdd:cd01319   1 FYLDLEFLLALISDGPAKSFCYRRLQYLESKFQLHVLLNEDRELKEQKTVPHRDFYNVRKVDTHVHHSACMNQKHLLRFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606  379 KHKLRHSKDEKVIFRDGKLLTLDEVFRSLHLTGYDLSIDTLDMHAHKDTFHRFDKFNLKYNPIGESRLREIFLKTNNYIK 458
Cdd:cd01319  81 KKKLRTEPDEVVIFRDGKKLTLKEVFDSLKLTAYDLSVDTLDVHADRNTFHRFDKFNLKYNPIGESRLREIFLKTDNYIN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606  459 GTYLADITKQVIFDLENSKYQNCEYRISVYGRSLDEWDKLASWVIDNKVISHNVRWLVQIPRLYDIYKKTGIVQSFQDIC 538
Cdd:cd01319 161 GRYLAEITKEVFSDLEESKYQHAEYRLSIYGRSKDEWDKLASWVVDNDLFSPNVRWLIQIPRLYDVYKKSGIVNSFQEML 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606  539 KNLFQPLFEVTKNPQSHPKLHVFLQRVIGFDSVDDESKVDRRFHRKYPKPSLWEAPQNPPYSYYLYYLYSNVASLNQWRA 618
Cdd:cd01319 241 ENIFEPLFEATKDPSSHPELHVFLQQVIGFDSVDDESKSERRFTRKFPKPEEWTSEENPPYSYYLYYMYANITTLNSFRK 320
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606  619 KRGFNTLVLRPHCGEAGDPEHLVSAYLLAHGISHGILLRKVPFVQYLYYLDQVGIAMSPLSNNALFLTYDKNPFPRYFKR 698
Cdd:cd01319 321 ARGFNTFVLRPHCGEAGDIDHLASAFLLAHGISHGINLRKVPVLQYLYYLTQIGIAMSPLSNNSLFLSYEKNPFPEFFKR 400
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606  699 GLNVSLSTDDPLQFSYTREPLIEEYSVAAQIYKLSNVDMCELARNSVLQSGWEAQIKKHWIGKDFDKSGVEGNDVVRTNV 778
Cdd:cd01319 401 GLNVSLSTDDPLQFHFTKEPLMEEYSIAAQVWKLSTCDMCELARNSVLQSGFEHSIKRHWLGPNYLKRGVAGNDIRRTNV 480
                       490
                ....*....|....*.
gi 6323606  779 PDIRINYRYDTLSTEL 794
Cdd:cd01319 481 PQIRMAYRYETLCEEL 496
AMP_deaminase TIGR01429
AMP deaminase; This model describes AMP deaminase, a large, well-conserved eukaryotic protein ...
188-797 0e+00

AMP deaminase; This model describes AMP deaminase, a large, well-conserved eukaryotic protein involved in energy metabolism. Most members of the family have an additional, poorly alignable region of 150 amino acids or more N-terminal to the region included in the model.


Pssm-ID: 273618 [Multi-domain]  Cd Length: 611  Bit Score: 837.19  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    188 ELIDLYSKVAECRNLRAKYQTISVQNDDQNPKNKPGWvvypPPPKPSYNSDTKTVVPVTNKPDAEVFDFTKCEIPGEDPD 267
Cdd:TIGR01429   2 DLAEAAKSLAKALMLREKYARLAYHRFPDTTAQYLSH----QGYPESVPLEEGLPDFHPPPDPQEDPYCLDDDAPPIELG 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    268 WEFTLNDDDSYVVHRSGKTDELIAQI---PTLRDYYLDLEKMISISSDGPAKSFAYRRLQYLEARWNLYYLLNEYQETSV 344
Cdd:TIGR01429  78 YLVRMHGGVLFVYDNDTMLERQEPHFlvpPTLETYYVDMEHLLALISDGPTKSFCFRRLQYLESKFNLHELLNEMSELKE 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    345 SKRNPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKHKLRHSKDEKVIFRDGKLLTLDEVFRSLHLTGYDLSIDTLDMHAH 424
Cdd:TIGR01429 158 QKSVPHRDFYNVRKVDTHIHAAASMNQKHLLRFIKHKLKTEPDETVIERDGKKLTLREVFDSLHLDPYDLSVDTLDVHAD 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    425 KDTFHRFDKFNLKYNPIGESRLREIFLKTNNYIKGTYLADITKQVIFDLENSKYQNCEYRISVYGRSLDEWDKLASWVID 504
Cdd:TIGR01429 238 RNTFHRFDKFNLKYNPVGESRLREIFLKTDNYIGGKYFAELVKEVFTDLEDSKYQYAEPRLSIYGRSPKEWDSLARWIID 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    505 NKVISHNVRWLVQIPRLYDIYKKTGIVQSFQDICKNLFQPLFEVTKNPQSHPKLHVFLQRVIGFDSVDDESK-VDRRFHR 583
Cdd:TIGR01429 318 HDVFSPNVRWLIQVPRLYDVYRSKKLVPNFGDMLENVFLPLFEVTKDPSSHPELHLFLQQVTGFDSVDDESKhEDHMFSR 397
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    584 KYPKPSLWEAPQNPPYSYYLYYLYSNVASLNQWRAKRGFNTLVLRPHCGEAGDPEHLVSAYLLAHGISHGILLRKVPFVQ 663
Cdd:TIGR01429 398 KFPSPDEWTSEQNPPYSYYLYYMYANIMVLNNFRRERGLNTFLLRPHCGEAGSVDHLVSAFLTSHGINHGILLRKVPVLQ 477
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    664 YLYYLDQVGIAMSPLSNNALFLTYDKNPFPRYFKRGLNVSLSTDDPLQFSYTREPLIEEYSVAAQIYKLSNVDMCELARN 743
Cdd:TIGR01429 478 YLYYLTQIPIAMSPLSNNSLFLEYSKNPLPEYLHKGLNVSLSTDDPLQFHYTKEALMEEYAIAAQVWKLSTCDMCELARN 557
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....
gi 6323606    744 SVLQSGWEAQIKKHWIGKDFDKSGVEGNDVVRTNVPDIRINYRYDTLSTELELV 797
Cdd:TIGR01429 558 SVLQSGFEHQVKQHWLGPNYYKEGPEGNDIRRTNVPDIRVAFRYETLCNELSLL 611
PLN03055 PLN03055
AMP deaminase; Provisional
183-797 0e+00

AMP deaminase; Provisional


Pssm-ID: 178613  Cd Length: 602  Bit Score: 722.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606   183 DDPSSELIDLYSKVAECRNLRAKYqtisvqnddqnpknkpgwvVYPPPPKPSYNSDTKtvvPVTNKPDAEVFDFTkceiP 262
Cdd:PLN03055   2 DAPSDEEEEVCAMMQECLELRDKY-------------------LFREKLPPWRKGIFE---SSTSKPNPDPFRYE----P 55
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606   263 GEDPDWEFTLNDDDSYVVHRSGKTDELIaQIPTLRDYYLDLEKMISISSDGPAKSFAYRRLQYLEARWNLYYLLNEYQET 342
Cdd:PLN03055  56 EPPSQHVFRMVDGVMHVYAPDDAKEELF-PVPDATTFFTDMHRILRIVSLGNVRTFCHHRLKLLEQKFSLHLMLNADREF 134
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606   343 SVSKRNPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKHKLRHSKDEKVIFRDGKLLTLDEVFRSLHLTGYDLSIDTLDMH 422
Cdd:PLN03055 135 LAQKSAPHRDFYNVRKVDTHVHHSSCMNQKHLLRFIKSKLRKEPDEVVIFRDGKYLTLREVFESLDLTGYDLNVDLLDVH 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606   423 AHKDTFHRFDKFNLKYNPIGESRLREIFLKTNNYIKGTYLADITKQVIFDLENSKYQNCEYRISVYGRSLDEWDKLASWV 502
Cdd:PLN03055 215 ADKNTFHRFDKFNLKYNPCGQSRLREIFLKQDNLIQGRFLAELTKEVFSDLEASKYQMAEYRISIYGRKQSEWDQLASWI 294
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606   503 IDNKVISHNVRWLVQIPRLYDIYKKTGIVQSFQDICKNLFQPLFEVTKNPQSHPKLHVFLQRVIGFDSVDDESKVDRRFH 582
Cdd:PLN03055 295 VNNRLYSENVVWLIQLPRLYNVYKEMGIVQSFQQILDNIFKPLFEVTVDPSSHPQLHVFLKMVVGFDMVDDESKPERRPT 374
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606   583 RKYPKPSLWEAPQNPPYSYYLYYLYSNVASLNQWRAKRGFNTLVLRPHCGEAGDPEHLVSAYLLAHGISHGILLRKVPFV 662
Cdd:PLN03055 375 KHMQTPEQWDIPFNPAYSYWAYYVYANLYTLNKLRESKGLNTIKFRPHAGEAGDIDHLAAAFLLAHNIAHGNNLRKSPGL 454
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606   663 QYLYYLDQVGIAMSPLSNNALFLTYDKNPFPRYFKRGLNVSLSTDDPLQFSYTREPLIEEYSVAAQIYKLSNVDMCELAR 742
Cdd:PLN03055 455 QYLYYLAQIGLAMSPLSNNSLFLDYHRNPFPMFFARGLNVSLSTDDPLQIHLTKEPLVEEYSIAAQVWKLSSCDLCEIAR 534
                        570       580       590       600       610
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 6323606   743 NSVLQSGWEAQIKKHWIGKDFDKSGVEGNDVVRTNVPDIRINYRYDTLSTELELV 797
Cdd:PLN03055 535 NSVLQSGFPHASKKHWVGDNYWLRGPAGNDIHKTNVPHMRVEFRHEVWKEELQYV 589
PLN02768 PLN02768
AMP deaminase
185-804 0e+00

AMP deaminase


Pssm-ID: 215411  Cd Length: 835  Bit Score: 700.85  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606   185 PSSELIDLYSKVAECRNLRAKYqtisVQNDDQNPKNKpgwvvyppppkpSYNSDtktvvPVTNKPDAEVFDFTkceiPGE 264
Cdd:PLN02768 236 PSPDEVEAYKVLQECLELRKRY----VFREEVAPWEK------------EIISD-----PSTPKPNPNPFSYT----PEG 290
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606   265 DPDWEFTLNDDDSYVVHRSGKTDEL--IAQIPTlrdYYLDLEKMISISSDGPAKSFAYRRLQYLEARWNLYYLLNEYQET 342
Cdd:PLN02768 291 KSDHYFEMQDGVVHVYANKDSKEELfpVADATT---FFTDLHHILRVIAAGNIRTLCHHRLNLLEQKFNLHLMLNADREF 367
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606   343 SVSKRNPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKHKLRHSKDEKVIFRDGKLLTLDEVFRSLHLTGYDLSIDTLDMH 422
Cdd:PLN02768 368 LAQKSAPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKSKLRKEPDEVVIFRDGTYLTLKEVFESLDLTGYDLNVDLLDVH 447
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606   423 AHKDTFHRFDKFNLKYNPIGESRLREIFLKTNNYIKGTYLADITKQVIFDLENSKYQNCEYRISVYGRSLDEWDKLASWV 502
Cdd:PLN02768 448 ADKSTFHRFDKFNLKYNPCGQSRLREIFLKQDNLIQGRFLAELTKQVFSDLEASKYQMAEYRISIYGRKQSEWDQLASWI 527
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606   503 IDNKVISHNVRWLVQIPRLYDIYKKTGIVQSFQDICKNLFQPLFEVTKNPQSHPKLHVFLQRVIGFDSVDDESKVDRRFH 582
Cdd:PLN02768 528 VNNELYSENVVWLIQLPRLYNVYKEMGIVTSFQNILDNIFIPLFEVTVDPDSHPQLHVFLKQVVGLDLVDDESKPERRPT 607
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606   583 RKYPKPSLWEAPQNPPYSYYLYYLYSNVASLNQWRAKRGFNTLVLRPHCGEAGDPEHLVSAYLLAHGISHGILLRKVPFV 662
Cdd:PLN02768 608 KHMPTPAQWTNVFNPAFSYYVYYCYANLYTLNKLRESKGMTTIKFRPHSGEAGDIDHLAATFLTCHNIAHGINLRKSPVL 687
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606   663 QYLYYLDQVGIAMSPLSNNALFLTYDKNPFPRYFKRGLNVSLSTDDPLQFSYTREPLIEEYSVAAQIYKLSNVDMCELAR 742
Cdd:PLN02768 688 QYLYYLAQIGLAMSPLSNNSLFLDYHRNPFPMFFLRGLNVSLSTDDPLQIHLTKEPLVEEYSIAASVWKLSSCDLCEIAR 767
                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6323606   743 NSVLQSGWEAQIKKHWIGKDFDKSGVEGNDVVRTNVPDIRINYRYDTLSTELELVnHFANFK 804
Cdd:PLN02768 768 NSVYQSGFSHALKSHWIGKEYYKRGPDGNDIHKTNVPHIRVEFRDTIWKEEMQQV-YLGKAK 828
PTZ00310 PTZ00310
AMP deaminase; Provisional
230-795 1.57e-166

AMP deaminase; Provisional


Pssm-ID: 240354 [Multi-domain]  Cd Length: 1453  Bit Score: 520.14  E-value: 1.57e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    230 PPKPSYNSDTKTVVPvtnkpdaevfDFTKCEIPGEDPDWEFTlNDDDSYVVHRSGKTDELIAQIPTLRDYYLDLEKMISI 309
Cdd:PTZ00310  727 PPPPWETTQRNVVEE----------DFQRTTRQFNEDQWTYA-AYDGVFILSPKGAVHAWPRFLPTLTEFIRDLSELRDI 795
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    310 SSDGPAKSFAYRRLQYLEARWNLYYLLNEYQE--TSVSKRNPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKHKLRHSKD 387
Cdd:PTZ00310  796 CSSVEVKRLATKRLENLEHKFRLHLALNHSNEagTTEERESSNRDFYQAYKVDTHIHMAAGMTARQLLEFVVDKLLESGD 875
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    388 EKVIFRDGKLLTLDEVFRSLHLTgYDLSIDTLDMHAHKDTFHRFDKFNLKYNPIGESRLREIFLKTNNYIKGTYLADITK 467
Cdd:PTZ00310  876 DIAFKRGDHIVTLGQLFSKYGIT-PNLTVDQLNVQADHTLFERFDNFNSKYNPMENPDLRSLLLKTDNFMKGRYFAELIK 954
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    468 QVIFDLENSKYQNCEYRISVYGRSLDEWDKLASWVIDNKVISHNVRWLVQIPRLYDIYKKTGIVQSFQDICKNLFQPLFE 547
Cdd:PTZ00310  955 DVFEQYSRDRFTYAENRLSIYGINVKEWDDLAHWFDTHGMASKHNKWMIQVPRVYKVFRAQNVIGSFGQYLDNIFQPLWE 1034
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    548 VTKNPQSHPKLHVFLQRVIGFDSVDDESKVDRRFHRKYPKPslWEAPQNPPYSYYLYYLYSNVASLNQWRAKRGFNTLVL 627
Cdd:PTZ00310 1035 ASLHPSKHPKFHYFLNHVSGFDSVDNEATIDLPFTDVSPWA--WTSVENPPYNYYLYYLYANIRTLNEFRASRGFSTFAL 1112
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    628 RPHCGEAGDPEHLVSAYLLAHGISHGILLRKVPFVQYLYYLDQVGIAMSPLSNNALFLTYDKNPFPRYFKRGLNVSLSTD 707
Cdd:PTZ00310 1113 RPHCGESGSMDHLYGAFLCANSICHGINLRNDPPMQYLYYLAQIGLHVSPLSNNALFLAFLENPFPVFFHRGLNVSLSTD 1192
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    708 DPLQFSYTREPLIEEYSVAAQIYKLSNVDMCELARNSVLQSGWEAQIKKHWIGKDFDKSGVEGNDVVRTNVPDIRINYRY 787
Cdd:PTZ00310 1193 DPLMFHQTQEPLIEEYSIAARVWGLSLNDLCEIARNSVLQSGFDAAFKRNAIGDRWYLSSSLGNDSLRTHLSDIRVAFRF 1272

                  ....*...
gi 6323606    788 DTLSTELE 795
Cdd:PTZ00310 1273 ETYHTELN 1280
PTZ00310 PTZ00310
AMP deaminase; Provisional
280-798 6.60e-71

AMP deaminase; Provisional


Pssm-ID: 240354 [Multi-domain]  Cd Length: 1453  Bit Score: 254.74  E-value: 6.60e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    280 VHRSGKTDELIAQIPTLRDYYLDLEKMISISSDGPAKSFAYRRLQYLEARWNLYYLLNEYQEtsvSKRNPHRD---FYNV 356
Cdd:PTZ00310  129 VYRFSGMDTSVVLPPPWEQYVRDVQAVYLTVGNGPCLSACRHRLTIIQERSRMFFLLNAEIE---ERADLYKAggvFSPC 205
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    357 RKVDTHVHHSACMNQKHLLRFIKHKLRHSKDEKVIFRDGKLLTLDEVFRSLHLTGYD-LSIDTLDMHAHKDTFH--RFDK 433
Cdd:PTZ00310  206 TKVDNAVLLSTSVDAQELLEFVVTTYREQPRAPLRLRDGSNSTLREYLEAHGVRDPReLTVEGLGWQPTKYRNKygQYDL 285
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    434 FNLKyNPIGE--SRLREIFLKTNNYIKGTYLADITKQVIFDLENSkyQNCEYRISVYGRSLDEWDKLASWVIDNKVISH- 510
Cdd:PTZ00310  286 FDAK-NPMGAlgAELRQSFLSLHGNLCGKLLRRELERREYQKQQP--QATEYSLPLYGHHPEELTDLAEWVRRQGFGPFs 362
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    511 NVRWLVQIPrlydiYKKTGIVQ------SFQDICKNLFQPLFEVTKNP--QSHPKLHVFLQRVIGFDSVDDESKVDRRFH 582
Cdd:PTZ00310  363 RNRWILAIS-----FKELGPFQvpssctTVQDQLDNIFLPLFKATLCPsdPQWSDVAWLLCQVGGLQILTHAVVRSEDFD 437
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    583 RKYPKPSLWEAPQNPPYSYYLYYLYSNVASLNQWRAKRGFNTLVLRPHCGEAGDPEHLVSAYLLAHGISHGILLRKVPFV 662
Cdd:PTZ00310  438 ETAPDPDQVPYTAKCSDLYYFYYVYANLAVLNSLRKRKGLNTLQLRPSGEKAPAYDQLISSYLLGDVITRATSIADYPVL 517
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606    663 QYLYYLDQVGIAMSPLSNNALFLT-YDKNPFPRYFKRGLNVSLSTDDPLQFSYTREPLIEEYSVAAQIYKLSNVDMCELA 741
Cdd:PTZ00310  518 QYLCGLHRVGLTVSPLRDHALSITaYFDHPLPKFLHRCLRVSISTSDPLYFHHHSQPLIEEYATAMKLFSLSPLDTTELA 597
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 6323606    742 RNSVLQSGWEAQIKKHWIGKDFDKsGVEGNDVVRTNVPDIRINYRYDTLSTELELVN 798
Cdd:PTZ00310  598 RNSVLNSSFPPEVKQQWLGERFQL-GVEGNDFERSGVTNYRLAFREEAWALEEALLN 653
ADA_AMPD cd00443
Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic ...
357-761 6.32e-61

Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase catalyzes a similar reaction leading to the hydrolytic removal of an amino group at the 6 position of the adenine nucleotide ring, a branch point in the adenylate catabolic pathway.


Pssm-ID: 238250  Cd Length: 305  Bit Score: 208.36  E-value: 6.32e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606  357 RKVDTHVHHSACMNQKHLLRFIKhklrhskdekvifrdgklltldevfrslhltgydlsidtldmhahkdtfhrfdkfnl 436
Cdd:cd00443   2 PKVELHAHLSGSISPETLLELIK--------------------------------------------------------- 24
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606  437 kynpigeSRLREIFLKTNNY-IKGTYLADITKQVIFDLENSKYQNCEYRISVYGRS-LDEWDKLASWVIDNKVISHNVRW 514
Cdd:cd00443  25 -------KEFFEKFLLVHNLlQKGEALARALKEVIEEFAEDNVQYLELRTTPRLLEtEKGLTKEQYWLLVIEGISEAKQW 97
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606  515 L--VQIPRLYDIYKKTGIVQSFQDicknlfqplfevtknPQSHPKLHVFL-QRVIGFDSVDDESKVDRRFHRKYPkpslw 591
Cdd:cd00443  98 FppIKVRLILSVDRRGPYVQNYLV---------------ASEILELAKFLsNYVVGIDLVGDESKGENPLRDFYS----- 157
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606  592 eapqnppysyylyylysnvaslnQWRAKRGFNTLVLRPHCGEAGDPEHLVSAYLL-AHGISHGILLRKVPFVQYLYYLDQ 670
Cdd:cd00443 158 -----------------------YYEYARRLGLLGLTLHCGETGNREELLQALLLlPDRIGHGIFLLKHPELIYLVKLRN 214
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606  671 VGIAMSPLSNNALFLT--YDKNPFPRYFKRGLNVSLSTDDPLQFSYtrePLIEEYSVAAQIYKLSNVDMCELARNSVLQS 748
Cdd:cd00443 215 IPIEVCPTSNVVLGTVqsYEKHPFMRFFKAGLPVSLSTDDPGIFGT---SLSEEYSLAAKTFGLTFEDLCELNRNSVLSS 291
                       410
                ....*....|...
gi 6323606  749 GWEAQIKKHWIGK 761
Cdd:cd00443 292 FAKDEEKKSLLEV 304
Add COG1816
Adenosine deaminase [Nucleotide transport and metabolism]; Adenosine deaminase is part of the ...
629-759 3.41e-16

Adenosine deaminase [Nucleotide transport and metabolism]; Adenosine deaminase is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 441421  Cd Length: 326  Bit Score: 80.51  E-value: 3.41e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606  629 PHCGEAGDPEHLVSA--YLLAHGISHGI-LLRKVPFVQYLyyLD-QVGIAMSPLSNNAL--FLTYDKNPFPRYFKRGLNV 702
Cdd:COG1816 186 AHAGEAGGPESIWEAldLLGAERIGHGVrAIEDPALVARL--ADrGIPLEVCPTSNVQLgvVPSLAEHPLRRLLDAGVRV 263
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6323606  703 SLSTDDPLQFSYTrepLIEEYSVAAQIYKLSNVDMCELARNSVLQSGWEAQIKKHWI 759
Cdd:COG1816 264 TLNTDDPLYFGTT---LTDEYELAAEAFGLSDADLAQLARNAIEASFLPEEEKAALL 317
PRK09358 PRK09358
adenosine deaminase; Provisional
629-761 3.10e-14

adenosine deaminase; Provisional


Pssm-ID: 236480  Cd Length: 340  Bit Score: 74.83  E-value: 3.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606   629 PHCGEAGDPEHLVSA--YLLAHGISHGI-------LLRkvpfvqylyYL--DQVGIAMSPLSNNAL--FLTYDKNPFPRY 695
Cdd:PRK09358 200 AHAGEAGGPESIWEAldELGAERIGHGVraiedpaLMA---------RLadRRIPLEVCPTSNVQTgaVPSLAEHPLKTL 270
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6323606   696 FKRGLNVSLSTDDPLqFSYTRepLIEEYSVAAQIYKLSNVDMCELARNSVLQSGWEAQIKKHWIGK 761
Cdd:PRK09358 271 LDAGVRVTINTDDPL-VFGTT--LTEEYEALAEAFGLSDEDLAQLARNALEAAFLSEEEKAALLAE 333
ADA cd01320
Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the ...
615-759 5.78e-14

Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in the purine pathway. Low, as well as high levels of ADA activity have been linked to several diseases.


Pssm-ID: 238645  Cd Length: 325  Bit Score: 73.78  E-value: 5.78e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606  615 QWRAKRGFNtlvLRPHCGEAGDPEHLVSA--YLLAHGISHGILLRKVPFVQYLYYLDQVGIAMSPLSNNAL--FLTYDKN 690
Cdd:cd01320 180 QRAREAGLR---LTAHAGEAGGPESVRDAldLLGAERIGHGIRAIEDPELVKRLAERNIPLEVCPTSNVQTgaVKSLAEH 256
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6323606  691 PFPRYFKRGLNVSLSTDDPLQFSYTrepLIEEYSVAAQIYKLSNVDMCELARNSVLQSGWEAQIKKHWI 759
Cdd:cd01320 257 PLRELLDAGVKVTINTDDPTVFGTY---LTDEYELLAEAFGLTEEELKKLARNAVEASFLSEEEKAELL 322
metallo-dependent_hydrolases cd01292
Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a ...
625-741 5.82e-08

Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The family includes urease alpha, adenosine deaminase, phosphotriesterase dihydroorotases, allantoinases, hydantoinases, AMP-, adenine and cytosine deaminases, imidazolonepropionase, aryldialkylphosphatase, chlorohydrolases, formylmethanofuran dehydrogenases and others.


Pssm-ID: 238617 [Multi-domain]  Cd Length: 275  Bit Score: 55.03  E-value: 5.82e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323606  625 LVLRPHCGEAGDPEH----LVSAYLLAHG--ISHGILLrkVPFVQYLYYLDQVGIAMSPLSNNALFLT-YDKNPFPRYFK 697
Cdd:cd01292 147 LPVVIHAGELPDPTRaledLVALLRLGGRvvIGHVSHL--DPELLELLKEAGVSLEVCPLSNYLLGRDgEGAEALRRLLE 224
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 6323606  698 RGLNVSLSTDDPlqFSYTREPLIEEYSVAAQIYKL--SNVDMCELA 741
Cdd:cd01292 225 LGIRVTLGTDGP--PHPLGTDLLALLRLLLKVLRLglSLEEALRLA 268
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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