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Conserved domains on  [gi|6323896|ref|NP_013967|]
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U2 snRNP complex subunit CUS1 [Saccharomyces cerevisiae S288C]

Protein Classification

splicing factor 3b subunit 2( domain architecture ID 11474100)

splicing factor 3b subunit 2 (SF3B2, also known as SAP145 and SF3b145) is a component of the SF3b complex assembled into the U2 snRNP complex which plays a role in the U2 snRNP complex to splice introns from the pre-mRNA

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CUS1 COG5182
Splicing factor 3b, subunit 2 [RNA processing and modification];
1-436 0e+00

Splicing factor 3b, subunit 2 [RNA processing and modification];


:

Pssm-ID: 227509 [Multi-domain]  Cd Length: 429  Bit Score: 645.51  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323896    1 MARTKSRKRSGNNQNKNASVVNNKAEIAAMIDARRLEQKKKGGVTNSKGKTNKVVDAKLEKEFKDVLQRFQVQENDTPKE 80
Cdd:COG5182   1 MARTKSRKRSGNNQNKNASVVNNKAEIAAMIDARRLEQKKKGGVTNSKGKTNKVVDAKLEKEFKDVLQRFQVQENDTPKE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323896   81 ITKDEKNNHVVIVEKNPVMNRKHTAEDEL--EDTPSDGIEEHLSARKRRKTEKPSLSQLKSQVPYPQIIEWYDCDARYPG 158
Cdd:COG5182  81 ITKDEKNMSRMKSRKAPTIHMEAEIDDEYgfEDRMKPYREESLSRQKKRKALQHRYEQLKLVVPYPEIFEWEDATCPDPM 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323896  159 LLASIKCTKNVIPVPSHWQSKKEYLSGRSLLGKRPFELPDIIKKTNIEQMRSTLPQSgldgQDEKSLKEASRARVQPKMG 238
Cdd:COG5182 161 SLNRMKGCSNGVPVPRHWRSKSRYLSGHGYHKPRPFELPRHIIGTGIPQMRRMMRER----EAGMSLRERIRERVQPKMG 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323896  239 ALDLDYKKLHDVFFKIGAnwKPdHLLCFGDVYYENRnlfeetNWKRMVDHKRPGRISQELRAIMNLPEGQLPPWCMKMKD 318
Cdd:COG5182 237 GLDVDYRKLHDAFFSLGP--KP-YLSKFGEFYEEVD------NDYRFVKKKRPGAISAELREALGIDSGTPPPWLFNMQK 307
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323896  319 IGLPTGYPDLKIAGLNWDITNLKGDVYGKIIPNHHSRS-KKQGRNYFGALISFETPEFENSKED-TQANAENGRQDDKID 396
Cdd:COG5182 308 HGMPPSYPDLKIPGLNWAPIPLEGDVYGYQPPGWHEPLfEVGPETAEGELLQFEAEEIYNDEEQyTRPVYENEDFEERVD 387
                       410       420       430       440
                ....*....|....*....|....*....|....*....|..
gi 6323896  397 DEVEHKLDHFQEDISEVTSAEEKLERN--EEESEKQLYTVLK 436
Cdd:COG5182 388 DVSNGGLAEFAPAAVEVAPKEDAKVTKrgKAKREKLLYSVLF 429
 
Name Accession Description Interval E-value
CUS1 COG5182
Splicing factor 3b, subunit 2 [RNA processing and modification];
1-436 0e+00

Splicing factor 3b, subunit 2 [RNA processing and modification];


Pssm-ID: 227509 [Multi-domain]  Cd Length: 429  Bit Score: 645.51  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323896    1 MARTKSRKRSGNNQNKNASVVNNKAEIAAMIDARRLEQKKKGGVTNSKGKTNKVVDAKLEKEFKDVLQRFQVQENDTPKE 80
Cdd:COG5182   1 MARTKSRKRSGNNQNKNASVVNNKAEIAAMIDARRLEQKKKGGVTNSKGKTNKVVDAKLEKEFKDVLQRFQVQENDTPKE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323896   81 ITKDEKNNHVVIVEKNPVMNRKHTAEDEL--EDTPSDGIEEHLSARKRRKTEKPSLSQLKSQVPYPQIIEWYDCDARYPG 158
Cdd:COG5182  81 ITKDEKNMSRMKSRKAPTIHMEAEIDDEYgfEDRMKPYREESLSRQKKRKALQHRYEQLKLVVPYPEIFEWEDATCPDPM 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323896  159 LLASIKCTKNVIPVPSHWQSKKEYLSGRSLLGKRPFELPDIIKKTNIEQMRSTLPQSgldgQDEKSLKEASRARVQPKMG 238
Cdd:COG5182 161 SLNRMKGCSNGVPVPRHWRSKSRYLSGHGYHKPRPFELPRHIIGTGIPQMRRMMRER----EAGMSLRERIRERVQPKMG 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323896  239 ALDLDYKKLHDVFFKIGAnwKPdHLLCFGDVYYENRnlfeetNWKRMVDHKRPGRISQELRAIMNLPEGQLPPWCMKMKD 318
Cdd:COG5182 237 GLDVDYRKLHDAFFSLGP--KP-YLSKFGEFYEEVD------NDYRFVKKKRPGAISAELREALGIDSGTPPPWLFNMQK 307
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323896  319 IGLPTGYPDLKIAGLNWDITNLKGDVYGKIIPNHHSRS-KKQGRNYFGALISFETPEFENSKED-TQANAENGRQDDKID 396
Cdd:COG5182 308 HGMPPSYPDLKIPGLNWAPIPLEGDVYGYQPPGWHEPLfEVGPETAEGELLQFEAEEIYNDEEQyTRPVYENEDFEERVD 387
                       410       420       430       440
                ....*....|....*....|....*....|....*....|..
gi 6323896  397 DEVEHKLDHFQEDISEVTSAEEKLERN--EEESEKQLYTVLK 436
Cdd:COG5182 388 DVSNGGLAEFAPAAVEVAPKEDAKVTKrgKAKREKLLYSVLF 429
DUF382 pfam04037
Domain of unknown function (DUF382); This domain is specific to the human splicing factor 3b ...
143-275 2.80e-67

Domain of unknown function (DUF382); This domain is specific to the human splicing factor 3b subunit 2 and it's orthologues. Splicing factor 3b subunit 2 or SAP145 is a suppressor of U2 snRNA mutations. Pre-mRNA splicing is catalyzed by a large ribonucleoprotein complex called the spliceosome. Spliceosomes are multi-component enzymes that catalyze pre-mRNA splicing and form step-wise by the ordered interaction of UsnRNPs and non-snRNP proteins with short conserved regions of the pre-mRNA at the 5' and 3' splice sites and branch site.


Pssm-ID: 461140  Cd Length: 126  Bit Score: 210.44  E-value: 2.80e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323896    143 YPQIIEWYDCDARYPGLLASIKCTKNVIPVPSHWQSKKEYLSGRSLLGKRPFELPDIIKKTNIEQMRSTLpqsgLDGQDE 222
Cdd:pfam04037   1 RPEVVEWYDVDAPDPYLLVHLKSSRNTVPVPSHWSQKRKYLSGKRGIEKPPFQLPDFIEDTGIEEMRDAL----LEKEDE 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 6323896    223 KSLKEASRARVQPKMGALDLDYKKLHDVFFKIGAnwKPdHLLCFGDVYYENRN 275
Cdd:pfam04037  77 KSLKQKQRERVQPKMGKLDIDYQKLHDAFFKFQT--KP-RLTPFGDLYYEGKE 126
PSP smart00581
proline-rich domain in spliceosome associated proteins;
286-339 3.38e-26

proline-rich domain in spliceosome associated proteins;


Pssm-ID: 128850  Cd Length: 54  Bit Score: 100.12  E-value: 3.38e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 6323896     286 VDHKRPGRISQELRAIMNLPEGQLPPWCMKMKDIGLPTGYPDLKIAGLNWDITN 339
Cdd:smart00581   1 FKHFKPGRISDELREALGLPPGQPPPWLYRMRRLGYPPGYPRLKIPGLNAPIPL 54
 
Name Accession Description Interval E-value
CUS1 COG5182
Splicing factor 3b, subunit 2 [RNA processing and modification];
1-436 0e+00

Splicing factor 3b, subunit 2 [RNA processing and modification];


Pssm-ID: 227509 [Multi-domain]  Cd Length: 429  Bit Score: 645.51  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323896    1 MARTKSRKRSGNNQNKNASVVNNKAEIAAMIDARRLEQKKKGGVTNSKGKTNKVVDAKLEKEFKDVLQRFQVQENDTPKE 80
Cdd:COG5182   1 MARTKSRKRSGNNQNKNASVVNNKAEIAAMIDARRLEQKKKGGVTNSKGKTNKVVDAKLEKEFKDVLQRFQVQENDTPKE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323896   81 ITKDEKNNHVVIVEKNPVMNRKHTAEDEL--EDTPSDGIEEHLSARKRRKTEKPSLSQLKSQVPYPQIIEWYDCDARYPG 158
Cdd:COG5182  81 ITKDEKNMSRMKSRKAPTIHMEAEIDDEYgfEDRMKPYREESLSRQKKRKALQHRYEQLKLVVPYPEIFEWEDATCPDPM 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323896  159 LLASIKCTKNVIPVPSHWQSKKEYLSGRSLLGKRPFELPDIIKKTNIEQMRSTLPQSgldgQDEKSLKEASRARVQPKMG 238
Cdd:COG5182 161 SLNRMKGCSNGVPVPRHWRSKSRYLSGHGYHKPRPFELPRHIIGTGIPQMRRMMRER----EAGMSLRERIRERVQPKMG 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323896  239 ALDLDYKKLHDVFFKIGAnwKPdHLLCFGDVYYENRnlfeetNWKRMVDHKRPGRISQELRAIMNLPEGQLPPWCMKMKD 318
Cdd:COG5182 237 GLDVDYRKLHDAFFSLGP--KP-YLSKFGEFYEEVD------NDYRFVKKKRPGAISAELREALGIDSGTPPPWLFNMQK 307
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323896  319 IGLPTGYPDLKIAGLNWDITNLKGDVYGKIIPNHHSRS-KKQGRNYFGALISFETPEFENSKED-TQANAENGRQDDKID 396
Cdd:COG5182 308 HGMPPSYPDLKIPGLNWAPIPLEGDVYGYQPPGWHEPLfEVGPETAEGELLQFEAEEIYNDEEQyTRPVYENEDFEERVD 387
                       410       420       430       440
                ....*....|....*....|....*....|....*....|..
gi 6323896  397 DEVEHKLDHFQEDISEVTSAEEKLERN--EEESEKQLYTVLK 436
Cdd:COG5182 388 DVSNGGLAEFAPAAVEVAPKEDAKVTKrgKAKREKLLYSVLF 429
DUF382 pfam04037
Domain of unknown function (DUF382); This domain is specific to the human splicing factor 3b ...
143-275 2.80e-67

Domain of unknown function (DUF382); This domain is specific to the human splicing factor 3b subunit 2 and it's orthologues. Splicing factor 3b subunit 2 or SAP145 is a suppressor of U2 snRNA mutations. Pre-mRNA splicing is catalyzed by a large ribonucleoprotein complex called the spliceosome. Spliceosomes are multi-component enzymes that catalyze pre-mRNA splicing and form step-wise by the ordered interaction of UsnRNPs and non-snRNP proteins with short conserved regions of the pre-mRNA at the 5' and 3' splice sites and branch site.


Pssm-ID: 461140  Cd Length: 126  Bit Score: 210.44  E-value: 2.80e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323896    143 YPQIIEWYDCDARYPGLLASIKCTKNVIPVPSHWQSKKEYLSGRSLLGKRPFELPDIIKKTNIEQMRSTLpqsgLDGQDE 222
Cdd:pfam04037   1 RPEVVEWYDVDAPDPYLLVHLKSSRNTVPVPSHWSQKRKYLSGKRGIEKPPFQLPDFIEDTGIEEMRDAL----LEKEDE 76
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 6323896    223 KSLKEASRARVQPKMGALDLDYKKLHDVFFKIGAnwKPdHLLCFGDVYYENRN 275
Cdd:pfam04037  77 KSLKQKQRERVQPKMGKLDIDYQKLHDAFFKFQT--KP-RLTPFGDLYYEGKE 126
PSP smart00581
proline-rich domain in spliceosome associated proteins;
286-339 3.38e-26

proline-rich domain in spliceosome associated proteins;


Pssm-ID: 128850  Cd Length: 54  Bit Score: 100.12  E-value: 3.38e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 6323896     286 VDHKRPGRISQELRAIMNLPEGQLPPWCMKMKDIGLPTGYPDLKIAGLNWDITN 339
Cdd:smart00581   1 FKHFKPGRISDELREALGLPPGQPPPWLYRMRRLGYPPGYPRLKIPGLNAPIPL 54
PSP pfam04046
PSP; Proline rich domain found in numerous spliceosome associated proteins.
290-335 5.86e-23

PSP; Proline rich domain found in numerous spliceosome associated proteins.


Pssm-ID: 461145  Cd Length: 46  Bit Score: 90.96  E-value: 5.86e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 6323896    290 RPGRISQELRAIMNLPEGQLPPWCMKMKDIGLPTGYPDLKIAGLNW 335
Cdd:pfam04046   1 KPGKLSDELREALGLPEGQPPPWLYRMQRLGPPPSYPNLKIPGLNA 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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