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Conserved domains on  [gi|6324005|ref|NP_014074|]
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phosphatidylinositol-3,5-bisphosphate 5-phosphatase [Saccharomyces cerevisiae S288C]

Protein Classification

SAC family polyphosphoinositide phosphatase( domain architecture ID 11474933)

SAC family polyphosphoinositide phosphatase catalyzes the hydrolysis of phosphatidylinositol (PtdIns) phosphates, such as PtdIns(3)P, PtdIns(4)P, and/or PtdIns(3,5)P2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5329 COG5329
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
31-653 0e+00

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


:

Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 638.67  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005   31 GKYTLYETKdRMYIVGSNKRETMFRILeidlTVPRGELTVLEDNVFFTRNEIMNVLASLEEAtedglHKKitgYGLLGFI 110
Cdd:COG5329   1 MQCFLGEKP-RSIAIVSNNYALSFRRL----GVKNSERILCATELVGVRFEPDEGFSSLSSA-----HKI---YGVIGLI 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005  111 KFTCWYYLIMVTKYSQVAVIGGHGIYHIDGIDIIPITNNYKKPEKSSDEARLLN--IFKDLDLTKTFYFSYTYDITNTLQ 188
Cdd:COG5329  68 KLKGDIYLIVITGASLVGVIPGHSIYKILDVDFISLNNNKWDDELEEDEANYDKlsELKKLLSNGTFYFSYDFDITNSLQ 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005  189 TNiLREKLKAVDRCDITIPCGITDYNEMFVWNNNLLSPIFACIDtvfDWFQCIIHGFIDQVNVSVLGKSIYITLIARRSH 268
Cdd:COG5329 148 KN-LSEGLEASVDRADLIFMWNSFLLEEFINHRSKLSSLEKQFD---NFLTTVIRGFAETVDIKVGGNTISLTLISRRSS 223

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005  269 HFAGARFLKRGVNNKGHVANEVETEQIVTDmiltpfhqpgngffdSDRYTSFVQHRGSIPLYWTQdaSNLTTKPPIRINV 348
Cdd:COG5329 224 ERAGTRYLSRGIDDDGNVSNFVETEQIVTD---------------SQYIFSFTQVRGSIPLFWEQ--SNLLYGPKIKVTR 286

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005  349 VDP-FFSPAALHFDNLFQRYGGgtIQILNLIKTKEktpRETKLLWEFEQCIDyLNEFLPTlkklDYTSWDMSRASKQDGQ 427
Cdd:COG5329 287 SSEaAQSAFDKHFDKLREKYGD--VYVVNLLKTKG---YEAPLLELYEKHLD-LSKKPKI----HYTEFDFHKETSQDGF 356

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005  428 GVIEFLEKYAVNTVTTTGIFH-NGPDFASTKIQEGICRSNCIDCLDRTNAAQFVIGkRALGCQLKSLGIIDNSYleydSD 506
Cdd:COG5329 357 DDVKKLLYLIEQDLLEFGYFAyDINEGKSISEQDGVFRTNCLDCLDRTNVIQSLIS-RVLLEQFRSEGVISDGY----SP 431

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005  507 IVNILTELFHDLGDTIALQYGGSHLVNTMETYRKINQWSSHSRDMIESIKRFYSNSFVDAQRQDAINLFLGHYSWREGFP 586
Cdd:COG5329 432 FLQIHRELWADNGDAISRLYTGTGALKSSFTRRGRRSFAGALNDFIKSFSRYYINNFTDGQRQDAIDLLLGKFRPQEAFS 511

                       570       580       590       600       610       620
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6324005  587 SLwemntdfYLHNAYSLNMPKRSYIHWWNDYNIKSVKELINEELIATGnDVTREKIIKNVRGYPGAF 653
Cdd:COG5329 512 YR-------PLRITFLLLMITACTISWFSTIIFISSLLCSNPSLLLVL-AVILIVLSKLYQFPHGRQ 570
 
Name Accession Description Interval E-value
COG5329 COG5329
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
31-653 0e+00

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 638.67  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005   31 GKYTLYETKdRMYIVGSNKRETMFRILeidlTVPRGELTVLEDNVFFTRNEIMNVLASLEEAtedglHKKitgYGLLGFI 110
Cdd:COG5329   1 MQCFLGEKP-RSIAIVSNNYALSFRRL----GVKNSERILCATELVGVRFEPDEGFSSLSSA-----HKI---YGVIGLI 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005  111 KFTCWYYLIMVTKYSQVAVIGGHGIYHIDGIDIIPITNNYKKPEKSSDEARLLN--IFKDLDLTKTFYFSYTYDITNTLQ 188
Cdd:COG5329  68 KLKGDIYLIVITGASLVGVIPGHSIYKILDVDFISLNNNKWDDELEEDEANYDKlsELKKLLSNGTFYFSYDFDITNSLQ 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005  189 TNiLREKLKAVDRCDITIPCGITDYNEMFVWNNNLLSPIFACIDtvfDWFQCIIHGFIDQVNVSVLGKSIYITLIARRSH 268
Cdd:COG5329 148 KN-LSEGLEASVDRADLIFMWNSFLLEEFINHRSKLSSLEKQFD---NFLTTVIRGFAETVDIKVGGNTISLTLISRRSS 223

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005  269 HFAGARFLKRGVNNKGHVANEVETEQIVTDmiltpfhqpgngffdSDRYTSFVQHRGSIPLYWTQdaSNLTTKPPIRINV 348
Cdd:COG5329 224 ERAGTRYLSRGIDDDGNVSNFVETEQIVTD---------------SQYIFSFTQVRGSIPLFWEQ--SNLLYGPKIKVTR 286

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005  349 VDP-FFSPAALHFDNLFQRYGGgtIQILNLIKTKEktpRETKLLWEFEQCIDyLNEFLPTlkklDYTSWDMSRASKQDGQ 427
Cdd:COG5329 287 SSEaAQSAFDKHFDKLREKYGD--VYVVNLLKTKG---YEAPLLELYEKHLD-LSKKPKI----HYTEFDFHKETSQDGF 356

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005  428 GVIEFLEKYAVNTVTTTGIFH-NGPDFASTKIQEGICRSNCIDCLDRTNAAQFVIGkRALGCQLKSLGIIDNSYleydSD 506
Cdd:COG5329 357 DDVKKLLYLIEQDLLEFGYFAyDINEGKSISEQDGVFRTNCLDCLDRTNVIQSLIS-RVLLEQFRSEGVISDGY----SP 431

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005  507 IVNILTELFHDLGDTIALQYGGSHLVNTMETYRKINQWSSHSRDMIESIKRFYSNSFVDAQRQDAINLFLGHYSWREGFP 586
Cdd:COG5329 432 FLQIHRELWADNGDAISRLYTGTGALKSSFTRRGRRSFAGALNDFIKSFSRYYINNFTDGQRQDAIDLLLGKFRPQEAFS 511

                       570       580       590       600       610       620
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6324005  587 SLwemntdfYLHNAYSLNMPKRSYIHWWNDYNIKSVKELINEELIATGnDVTREKIIKNVRGYPGAF 653
Cdd:COG5329 512 YR-------PLRITFLLLMITACTISWFSTIIFISSLLCSNPSLLLVL-AVILIVLSKLYQFPHGRQ 570
Syja_N pfam02383
SacI homology domain; This Pfam family represents a protein domain which shows homology to the ...
 104-423 7.85e-127

SacI homology domain; This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.


Pssm-ID: 460545  Cd Length: 295  Bit Score: 383.46  E-value: 7.85e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005    104 YGLLGFIKFTCWYYLIMVTKYSQVAVIGGHGIYHIDGIDIIPITNNYKK----PEKSSDEARLLNIFKDLDLTKTFYFSY 179
Cdd:pfam02383   1 YGILGLIRLLSGYYLIVITKREQVGQIGGHPIYKITDVEFIPLNSSLSDtqlaKKEHPDEERLLKLLKLFLSSGSFYFSY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005    180 TYDITNTLQTNILREKLKAVDRCDitipcgitdynEMFVWNNNLLSPIFACIDTVFDWFQCIIHGFIDQVNVSVLGKSIY 259
Cdd:pfam02383  81 DYDLTNSLQRNLTRSRSPSFDSLD-----------DRFFWNRHLLKPLIDFQLDLDRWILPLIQGFVEQGKLSVFGRSVT 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005    260 ITLIARRSHHFAGARFLKRGVNNKGHVANEVETEQIVTDMILTPfhqpgngffdSDRYTSFVQHRGSIPLYWTQDaSNLT 339
Cdd:pfam02383 150 LTLISRRSRKRAGTRYLRRGIDDDGNVANFVETEQIVSLNTSNS----------EGKIFSFVQIRGSIPLFWSQD-PNLK 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005    340 TKPPIRINVVDPFFSPAALHFDNLFQRYggGTIQILNLIktkEKTPRETKLLWEFEQCIDYLNEFLPtlKKLDYTSWDMS 419
Cdd:pfam02383 219 YKPKIQITRPEATQPAFKKHFDDLIERY--GPVHIVNLV---EKKGRESKLSEAYEEAVKYLNQFLP--DKLRYTAFDFH 291


                  ....
gi 6324005    420 RASK 423
Cdd:pfam02383 292 HECK 295
 
Name Accession Description Interval E-value
COG5329 COG5329
Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];
31-653 0e+00

Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms];


Pssm-ID: 227637 [Multi-domain]  Cd Length: 570  Bit Score: 638.67  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005   31 GKYTLYETKdRMYIVGSNKRETMFRILeidlTVPRGELTVLEDNVFFTRNEIMNVLASLEEAtedglHKKitgYGLLGFI 110
Cdd:COG5329   1 MQCFLGEKP-RSIAIVSNNYALSFRRL----GVKNSERILCATELVGVRFEPDEGFSSLSSA-----HKI---YGVIGLI 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005  111 KFTCWYYLIMVTKYSQVAVIGGHGIYHIDGIDIIPITNNYKKPEKSSDEARLLN--IFKDLDLTKTFYFSYTYDITNTLQ 188
Cdd:COG5329  68 KLKGDIYLIVITGASLVGVIPGHSIYKILDVDFISLNNNKWDDELEEDEANYDKlsELKKLLSNGTFYFSYDFDITNSLQ 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005  189 TNiLREKLKAVDRCDITIPCGITDYNEMFVWNNNLLSPIFACIDtvfDWFQCIIHGFIDQVNVSVLGKSIYITLIARRSH 268
Cdd:COG5329 148 KN-LSEGLEASVDRADLIFMWNSFLLEEFINHRSKLSSLEKQFD---NFLTTVIRGFAETVDIKVGGNTISLTLISRRSS 223

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005  269 HFAGARFLKRGVNNKGHVANEVETEQIVTDmiltpfhqpgngffdSDRYTSFVQHRGSIPLYWTQdaSNLTTKPPIRINV 348
Cdd:COG5329 224 ERAGTRYLSRGIDDDGNVSNFVETEQIVTD---------------SQYIFSFTQVRGSIPLFWEQ--SNLLYGPKIKVTR 286

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005  349 VDP-FFSPAALHFDNLFQRYGGgtIQILNLIKTKEktpRETKLLWEFEQCIDyLNEFLPTlkklDYTSWDMSRASKQDGQ 427
Cdd:COG5329 287 SSEaAQSAFDKHFDKLREKYGD--VYVVNLLKTKG---YEAPLLELYEKHLD-LSKKPKI----HYTEFDFHKETSQDGF 356

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005  428 GVIEFLEKYAVNTVTTTGIFH-NGPDFASTKIQEGICRSNCIDCLDRTNAAQFVIGkRALGCQLKSLGIIDNSYleydSD 506
Cdd:COG5329 357 DDVKKLLYLIEQDLLEFGYFAyDINEGKSISEQDGVFRTNCLDCLDRTNVIQSLIS-RVLLEQFRSEGVISDGY----SP 431

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005  507 IVNILTELFHDLGDTIALQYGGSHLVNTMETYRKINQWSSHSRDMIESIKRFYSNSFVDAQRQDAINLFLGHYSWREGFP 586
Cdd:COG5329 432 FLQIHRELWADNGDAISRLYTGTGALKSSFTRRGRRSFAGALNDFIKSFSRYYINNFTDGQRQDAIDLLLGKFRPQEAFS 511

                       570       580       590       600       610       620
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6324005  587 SLwemntdfYLHNAYSLNMPKRSYIHWWNDYNIKSVKELINEELIATGnDVTREKIIKNVRGYPGAF 653
Cdd:COG5329 512 YR-------PLRITFLLLMITACTISWFSTIIFISSLLCSNPSLLLVL-AVILIVLSKLYQFPHGRQ 570
Syja_N pfam02383
SacI homology domain; This Pfam family represents a protein domain which shows homology to the ...
 104-423 7.85e-127

SacI homology domain; This Pfam family represents a protein domain which shows homology to the yeast protein SacI. The SacI homology domain is most notably found at the amino terminal of the inositol 5'-phosphatase synaptojanin.


Pssm-ID: 460545  Cd Length: 295  Bit Score: 383.46  E-value: 7.85e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005    104 YGLLGFIKFTCWYYLIMVTKYSQVAVIGGHGIYHIDGIDIIPITNNYKK----PEKSSDEARLLNIFKDLDLTKTFYFSY 179
Cdd:pfam02383   1 YGILGLIRLLSGYYLIVITKREQVGQIGGHPIYKITDVEFIPLNSSLSDtqlaKKEHPDEERLLKLLKLFLSSGSFYFSY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005    180 TYDITNTLQTNILREKLKAVDRCDitipcgitdynEMFVWNNNLLSPIFACIDTVFDWFQCIIHGFIDQVNVSVLGKSIY 259
Cdd:pfam02383  81 DYDLTNSLQRNLTRSRSPSFDSLD-----------DRFFWNRHLLKPLIDFQLDLDRWILPLIQGFVEQGKLSVFGRSVT 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005    260 ITLIARRSHHFAGARFLKRGVNNKGHVANEVETEQIVTDMILTPfhqpgngffdSDRYTSFVQHRGSIPLYWTQDaSNLT 339
Cdd:pfam02383 150 LTLISRRSRKRAGTRYLRRGIDDDGNVANFVETEQIVSLNTSNS----------EGKIFSFVQIRGSIPLFWSQD-PNLK 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324005    340 TKPPIRINVVDPFFSPAALHFDNLFQRYggGTIQILNLIktkEKTPRETKLLWEFEQCIDYLNEFLPtlKKLDYTSWDMS 419
Cdd:pfam02383 219 YKPKIQITRPEATQPAFKKHFDDLIERY--GPVHIVNLV---EKKGRESKLSEAYEEAVKYLNQFLP--DKLRYTAFDFH 291


                  ....
gi 6324005    420 RASK 423
Cdd:pfam02383 292 HECK 295
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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