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Conserved domains on  [gi|6324084|ref|NP_014154|]
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U2-type spliceosomal complex subunit CWC25 [Saccharomyces cerevisiae S288C]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cir_N pfam10197
N-terminal domain of CBF1 interacting co-repressor CIR; This is a 45 residue conserved region ...
 11-47 9.09e-10

N-terminal domain of CBF1 interacting co-repressor CIR; This is a 45 residue conserved region at the N-terminal end of a family of proteins referred to as CIRs (CBF1-interacting co-repressors). CBF1 (centromere-binding factor 1) acts as a transcription factor that causes repression by binding specifically to GTGGGAA motifs in responsive promoters, and it requires CIR as a co-repressor. CIR binds to histone deacetylase and to SAP30 and serves as a linker between CBF1 and the histone deacetylase complex.


:

Pssm-ID: 462992 [Multi-domain]  Cd Length: 37  Bit Score: 51.64  E-value: 9.09e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 6324084     11 SWNPKLMKNRKKVWETEQDLITEQQKLNTRLKEIEKE 47
Cdd:pfam10197   1 SWHPGLKKNQEKVWKAEQKALEERKKIEERKKEIEEE 37
CWC25 super family cl13918
Pre-mRNA splicing factor; This domain family is found in eukaryotes, and is approximately 100 ...
 74-153 1.14e-03

Pre-mRNA splicing factor; This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with pfam10197. There is a single completely conserved residue Y that may be functionally important. Cwc25 has been identified to associate with pre-mRNA splicing factor Cef1/Ntc85, a component of the Prp19-associated complex (NTC) involved in spliceosome activation. Cwc25 is neither tightly associated with NTC nor required for spliceosome activation, but is required for the first catalytic reaction.


The actual alignment was detected with superfamily member pfam12542:

Pssm-ID: 463626 [Multi-domain]  Cd Length: 97  Bit Score: 36.66  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324084     74 SGLEWMYQDAKL--SDEKEDYLLGKKKLDSSILNQPATPPVRAATTISASGAATSISSQKKKSKLLKD-------DPMSK 144
Cdd:pfam12542   2 ERLDWMYDGPSGgvEEEMEEYLLGKKRVDKLLEGGDDAEKKKAAKASFSAASVPGALFLEKAINSARDtarklreDPLLA 81


                  ....*....
gi 6324084    145 FKVTKQQRR 153
Cdd:pfam12542  82 IKKQEQEAR 90
 
Name Accession Description Interval E-value
Cir_N pfam10197
N-terminal domain of CBF1 interacting co-repressor CIR; This is a 45 residue conserved region ...
 11-47 9.09e-10

N-terminal domain of CBF1 interacting co-repressor CIR; This is a 45 residue conserved region at the N-terminal end of a family of proteins referred to as CIRs (CBF1-interacting co-repressors). CBF1 (centromere-binding factor 1) acts as a transcription factor that causes repression by binding specifically to GTGGGAA motifs in responsive promoters, and it requires CIR as a co-repressor. CIR binds to histone deacetylase and to SAP30 and serves as a linker between CBF1 and the histone deacetylase complex.


Pssm-ID: 462992 [Multi-domain]  Cd Length: 37  Bit Score: 51.64  E-value: 9.09e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 6324084     11 SWNPKLMKNRKKVWETEQDLITEQQKLNTRLKEIEKE 47
Cdd:pfam10197   1 SWHPGLKKNQEKVWKAEQKALEERKKIEERKKEIEEE 37
Cir_N smart01083
N-terminal domain of CBF1 interacting co-repressor CIR; This is a 45 residue conserved region ...
 11-47 1.07e-09

N-terminal domain of CBF1 interacting co-repressor CIR; This is a 45 residue conserved region at the N-terminal end of a family of proteins referred to as CIRs (CBF1-interacting co-repressors). CBF1 (centromere-binding factor 1) acts as a transcription factor that causes repression by binding specifically to GTGGGAA motifs in responsive promoters, and it requires CIR as a co-repressor. CIR binds to histone deacetylase and to SAP30 and serves as a linker between CBF1 and the histone deacetylase complex.


Pssm-ID: 198151 [Multi-domain]  Cd Length: 37  Bit Score: 51.39  E-value: 1.07e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 6324084      11 SWNPKLMKNRKKVWETEQDLITEQQKLNTRLKEIEKE 47
Cdd:smart01083   1 SWHPGNKKNQKRVWKAEQKAEEEKKKIEERRKEIEKE 37
CWC25 pfam12542
Pre-mRNA splicing factor; This domain family is found in eukaryotes, and is approximately 100 ...
 74-153 1.14e-03

Pre-mRNA splicing factor; This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with pfam10197. There is a single completely conserved residue Y that may be functionally important. Cwc25 has been identified to associate with pre-mRNA splicing factor Cef1/Ntc85, a component of the Prp19-associated complex (NTC) involved in spliceosome activation. Cwc25 is neither tightly associated with NTC nor required for spliceosome activation, but is required for the first catalytic reaction.


Pssm-ID: 463626 [Multi-domain]  Cd Length: 97  Bit Score: 36.66  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324084     74 SGLEWMYQDAKL--SDEKEDYLLGKKKLDSSILNQPATPPVRAATTISASGAATSISSQKKKSKLLKD-------DPMSK 144
Cdd:pfam12542   2 ERLDWMYDGPSGgvEEEMEEYLLGKKRVDKLLEGGDDAEKKKAAKASFSAASVPGALFLEKAINSARDtarklreDPLLA 81


                  ....*....
gi 6324084    145 FKVTKQQRR 153
Cdd:pfam12542  82 IKKQEQEAR 90
 
Name Accession Description Interval E-value
Cir_N pfam10197
N-terminal domain of CBF1 interacting co-repressor CIR; This is a 45 residue conserved region ...
 11-47 9.09e-10

N-terminal domain of CBF1 interacting co-repressor CIR; This is a 45 residue conserved region at the N-terminal end of a family of proteins referred to as CIRs (CBF1-interacting co-repressors). CBF1 (centromere-binding factor 1) acts as a transcription factor that causes repression by binding specifically to GTGGGAA motifs in responsive promoters, and it requires CIR as a co-repressor. CIR binds to histone deacetylase and to SAP30 and serves as a linker between CBF1 and the histone deacetylase complex.


Pssm-ID: 462992 [Multi-domain]  Cd Length: 37  Bit Score: 51.64  E-value: 9.09e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 6324084     11 SWNPKLMKNRKKVWETEQDLITEQQKLNTRLKEIEKE 47
Cdd:pfam10197   1 SWHPGLKKNQEKVWKAEQKALEERKKIEERKKEIEEE 37
Cir_N smart01083
N-terminal domain of CBF1 interacting co-repressor CIR; This is a 45 residue conserved region ...
 11-47 1.07e-09

N-terminal domain of CBF1 interacting co-repressor CIR; This is a 45 residue conserved region at the N-terminal end of a family of proteins referred to as CIRs (CBF1-interacting co-repressors). CBF1 (centromere-binding factor 1) acts as a transcription factor that causes repression by binding specifically to GTGGGAA motifs in responsive promoters, and it requires CIR as a co-repressor. CIR binds to histone deacetylase and to SAP30 and serves as a linker between CBF1 and the histone deacetylase complex.


Pssm-ID: 198151 [Multi-domain]  Cd Length: 37  Bit Score: 51.39  E-value: 1.07e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 6324084      11 SWNPKLMKNRKKVWETEQDLITEQQKLNTRLKEIEKE 47
Cdd:smart01083   1 SWHPGNKKNQKRVWKAEQKAEEEKKKIEERRKEIEKE 37
CWC25 pfam12542
Pre-mRNA splicing factor; This domain family is found in eukaryotes, and is approximately 100 ...
 74-153 1.14e-03

Pre-mRNA splicing factor; This domain family is found in eukaryotes, and is approximately 100 amino acids in length. The family is found in association with pfam10197. There is a single completely conserved residue Y that may be functionally important. Cwc25 has been identified to associate with pre-mRNA splicing factor Cef1/Ntc85, a component of the Prp19-associated complex (NTC) involved in spliceosome activation. Cwc25 is neither tightly associated with NTC nor required for spliceosome activation, but is required for the first catalytic reaction.


Pssm-ID: 463626 [Multi-domain]  Cd Length: 97  Bit Score: 36.66  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324084     74 SGLEWMYQDAKL--SDEKEDYLLGKKKLDSSILNQPATPPVRAATTISASGAATSISSQKKKSKLLKD-------DPMSK 144
Cdd:pfam12542   2 ERLDWMYDGPSGgvEEEMEEYLLGKKRVDKLLEGGDDAEKKKAAKASFSAASVPGALFLEKAINSARDtarklreDPLLA 81


                  ....*....
gi 6324084    145 FKVTKQQRR 153
Cdd:pfam12542  82 IKKQEQEAR 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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