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Conserved domains on  [gi|6324433|ref|NP_014502|]
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translation initiation factor eIF4E [Saccharomyces cerevisiae S288C]

Protein Classification

eukaryotic translation initiation factor 4E family protein( domain architecture ID 10009059)

eukaryotic translation initiation factor 4E (EIF4E) family protein recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of secondary structures of mRNAs

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CDC33 COG5053
Translation initiation factor 4E (eIF-4E) [Translation, ribosomal structure and biogenesis];
1-213 2.23e-114

Translation initiation factor 4E (eIF-4E) [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 227386  Cd Length: 217  Bit Score: 325.31  E-value: 2.23e-114
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324433    1 MSVEEVSKKFEENVSVDDTTATPKTVLSDSAHFDVKHPLNTKWTLWYTKPAVDKSESWSDLLRPVTSFQTVEEFWAIIQN 80
Cdd:COG5053   1 MSTEEVSKKFEENVSVDPTTKTPRTVLSDSAHFMNKHPLAFHWTLWFLKPPEDGLESWSDLLKSIITFETVEEFWYILHN 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324433   81 IPEPHELPLKSDYHVFRNDVRPEWEDEANAKGGKWSFQLRGKGAD-IDELWLRTLLAVIGETIDEDDSQINGVVLSIRKG 159
Cdd:COG5053  81 ISDASRLPRKSDYNVFREGIRPEWEDEANMNGGKWSFQLKGKGCDrLDELWLRTLLAAIGETLDPTGSEIGGVVGNMRKG 160
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6324433  160 GNKFALWTKS-EDKEPLLRIGGKFKQVLKLTDDGHLEFFPH-SSANG-RHPQPSITL 213
Cdd:COG5053 161 FYKLAIWTRNcNNKDVLGAIGNEFKQVLELSDVETLEYKAHeSSKLGsYHAKTRMSL 217
 
Name Accession Description Interval E-value
CDC33 COG5053
Translation initiation factor 4E (eIF-4E) [Translation, ribosomal structure and biogenesis];
1-213 2.23e-114

Translation initiation factor 4E (eIF-4E) [Translation, ribosomal structure and biogenesis];


Pssm-ID: 227386  Cd Length: 217  Bit Score: 325.31  E-value: 2.23e-114
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324433    1 MSVEEVSKKFEENVSVDDTTATPKTVLSDSAHFDVKHPLNTKWTLWYTKPAVDKSESWSDLLRPVTSFQTVEEFWAIIQN 80
Cdd:COG5053   1 MSTEEVSKKFEENVSVDPTTKTPRTVLSDSAHFMNKHPLAFHWTLWFLKPPEDGLESWSDLLKSIITFETVEEFWYILHN 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324433   81 IPEPHELPLKSDYHVFRNDVRPEWEDEANAKGGKWSFQLRGKGAD-IDELWLRTLLAVIGETIDEDDSQINGVVLSIRKG 159
Cdd:COG5053  81 ISDASRLPRKSDYNVFREGIRPEWEDEANMNGGKWSFQLKGKGCDrLDELWLRTLLAAIGETLDPTGSEIGGVVGNMRKG 160
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6324433  160 GNKFALWTKS-EDKEPLLRIGGKFKQVLKLTDDGHLEFFPH-SSANG-RHPQPSITL 213
Cdd:COG5053 161 FYKLAIWTRNcNNKDVLGAIGNEFKQVLELSDVETLEYKAHeSSKLGsYHAKTRMSL 217
IF4E pfam01652
Eukaryotic initiation factor 4E;
38-196 1.82e-76

Eukaryotic initiation factor 4E;


Pssm-ID: 460281  Cd Length: 158  Bit Score: 227.02  E-value: 1.82e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324433     38 PLNTKWTLWYTKPAvDKSESWSDLLRPVTSFQTVEEFWAIIQNIPEPHELPLKSDYHVFRNDVRPEWEDEANAKGGKWSF 117
Cdd:pfam01652   1 PLQNTWTLWYDTKP-DKSKSYEDNLKKIGTFDTVEDFWSLYNHIKPPSELPPGSDYHLFKEGIKPMWEDPANKNGGKWII 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324433    118 QLRgKGADIDELWLRTLLAVIGETIDEDDSQINGVVLSIRKGGNKFALWTKS-EDKEPLLRIGGKFKQVLKLTDDGHLEF 196
Cdd:pfam01652  80 RLK-KKGLLDRLWEDLLLALIGEQFDEDSDEICGAVVSVRKKEDKISIWTRDaSDEEAVLKIGKKLKEVLGLPPNTKIEY 158
PTZ00040 PTZ00040
translation initiation factor E4; Provisional
4-168 8.03e-19

translation initiation factor E4; Provisional


Pssm-ID: 240238  Cd Length: 233  Bit Score: 81.40  E-value: 8.03e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324433     4 EEVSKKFEENVSVDDTTATPKTVLSDSAHFDVKHPLNTKWTLW--YTKPAVDKSESWSDLLRPVTSFQTVEEFWAIIQNI 81
Cdd:PTZ00040   5 TVVSKYLTFNKSIEDALDLSELFEETKIPLSTPLPLSYKWVIWeqVVKETIRKSNDYKDYTKPLASFDSVQKFWQLWFNI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324433    82 PEPHELP-------LKSD--YHV------FRNDVRPEWEDEANAKGGKWSFQLRGKG---ADIDELWLRTLLAVIGETId 143
Cdd:PTZ00040  85 PQPSELLtgkrmirESSDgsEHVvdavmiFKDGIQPMWEDPMNATGGHFEYRFWPTDvspGQIDEYWNNLVLALIGSSL- 163
                        170       180
                 ....*....|....*....|....*....
gi 6324433   144 EDDSQINGV----VLSIRKGGNKFALWTK 168
Cdd:PTZ00040 164 EHSSLINGIrlvdKLSGRFGVIRIEIWFT 192
 
Name Accession Description Interval E-value
CDC33 COG5053
Translation initiation factor 4E (eIF-4E) [Translation, ribosomal structure and biogenesis];
1-213 2.23e-114

Translation initiation factor 4E (eIF-4E) [Translation, ribosomal structure and biogenesis];


Pssm-ID: 227386  Cd Length: 217  Bit Score: 325.31  E-value: 2.23e-114
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324433    1 MSVEEVSKKFEENVSVDDTTATPKTVLSDSAHFDVKHPLNTKWTLWYTKPAVDKSESWSDLLRPVTSFQTVEEFWAIIQN 80
Cdd:COG5053   1 MSTEEVSKKFEENVSVDPTTKTPRTVLSDSAHFMNKHPLAFHWTLWFLKPPEDGLESWSDLLKSIITFETVEEFWYILHN 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324433   81 IPEPHELPLKSDYHVFRNDVRPEWEDEANAKGGKWSFQLRGKGAD-IDELWLRTLLAVIGETIDEDDSQINGVVLSIRKG 159
Cdd:COG5053  81 ISDASRLPRKSDYNVFREGIRPEWEDEANMNGGKWSFQLKGKGCDrLDELWLRTLLAAIGETLDPTGSEIGGVVGNMRKG 160
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 6324433  160 GNKFALWTKS-EDKEPLLRIGGKFKQVLKLTDDGHLEFFPH-SSANG-RHPQPSITL 213
Cdd:COG5053 161 FYKLAIWTRNcNNKDVLGAIGNEFKQVLELSDVETLEYKAHeSSKLGsYHAKTRMSL 217
IF4E pfam01652
Eukaryotic initiation factor 4E;
38-196 1.82e-76

Eukaryotic initiation factor 4E;


Pssm-ID: 460281  Cd Length: 158  Bit Score: 227.02  E-value: 1.82e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324433     38 PLNTKWTLWYTKPAvDKSESWSDLLRPVTSFQTVEEFWAIIQNIPEPHELPLKSDYHVFRNDVRPEWEDEANAKGGKWSF 117
Cdd:pfam01652   1 PLQNTWTLWYDTKP-DKSKSYEDNLKKIGTFDTVEDFWSLYNHIKPPSELPPGSDYHLFKEGIKPMWEDPANKNGGKWII 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324433    118 QLRgKGADIDELWLRTLLAVIGETIDEDDSQINGVVLSIRKGGNKFALWTKS-EDKEPLLRIGGKFKQVLKLTDDGHLEF 196
Cdd:pfam01652  80 RLK-KKGLLDRLWEDLLLALIGEQFDEDSDEICGAVVSVRKKEDKISIWTRDaSDEEAVLKIGKKLKEVLGLPPNTKIEY 158
PTZ00040 PTZ00040
translation initiation factor E4; Provisional
4-168 8.03e-19

translation initiation factor E4; Provisional


Pssm-ID: 240238  Cd Length: 233  Bit Score: 81.40  E-value: 8.03e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324433     4 EEVSKKFEENVSVDDTTATPKTVLSDSAHFDVKHPLNTKWTLW--YTKPAVDKSESWSDLLRPVTSFQTVEEFWAIIQNI 81
Cdd:PTZ00040   5 TVVSKYLTFNKSIEDALDLSELFEETKIPLSTPLPLSYKWVIWeqVVKETIRKSNDYKDYTKPLASFDSVQKFWQLWFNI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324433    82 PEPHELP-------LKSD--YHV------FRNDVRPEWEDEANAKGGKWSFQLRGKG---ADIDELWLRTLLAVIGETId 143
Cdd:PTZ00040  85 PQPSELLtgkrmirESSDgsEHVvdavmiFKDGIQPMWEDPMNATGGHFEYRFWPTDvspGQIDEYWNNLVLALIGSSL- 163
                        170       180
                 ....*....|....*....|....*....
gi 6324433   144 EDDSQINGV----VLSIRKGGNKFALWTK 168
Cdd:PTZ00040 164 EHSSLINGIrlvdKLSGRFGVIRIEIWFT 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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