|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
96-490 |
4.20e-94 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 289.84 E-value: 4.20e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 96 AWLVVFGAFMGLVPVFGLINSLGAIESYISKHqlANISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIY 175
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEE--FGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 176 AGGLFALANCKSVWQFILAFSVCSGLGTGILMTPLIGTVATWFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQW 255
Cdd:cd17352 79 ALGLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 256 AIRILSFICLTCLICASVLarertkpvvqpfkskaevakwyissvfnwRYFLEGKFLFVAIGASFAESSLTSCATYLASY 335
Cdd:cd17352 159 ALLILGGLCLNLCVCGLLL-----------------------------RLLKDPTFVLLALGVSFAMLGFFVPFVYLPSY 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 336 SMTRGNTENVAYTMITASNAVGILGRYIPGYFADKF-IGRFNVEIITISMAALFNFVMWLPFggNTKVLWAYVCLWGFST 414
Cdd:cd17352 210 AKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPrIGRLYLYIFTLLILGLSLLAFPLAT--TYVGLIVFSVLFGFCS 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6324453 415 GSILSLTPVCIGQISKTTDFGKRYATVYLLQALVTIPVLPIGGTLIgkGTVANYNHFIIFNSALMAAGAACYIISR 490
Cdd:cd17352 288 GSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLR--DYTGDYDAAFYFCGACLLLSGVLLFLLP 361
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
96-447 |
6.61e-26 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 109.28 E-value: 6.61e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 96 AWLVVFGAFMGLVPVFGLINSLGAIesYISKHQLANISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIY 175
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVF--IIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 176 AGGLFALANCKSVWQFILAFSVCSGLGTGILMTPLIGTVATW-FLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQ 254
Cdd:cd17355 79 AAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWwFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 255 WAIRILSFICLTCLICASVLARERTKPVVQPFKSKAEVAKWYISSVFNWRyflEGKFLFVAIGASFAESSLTSCATYLAS 334
Cdd:cd17355 159 TALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKEALR---SASFWLLALAFFLCGFAVVGLIVHLVP 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 335 YSMTRGNTENVAYTMITASNAVGILGRYIPGYFADKFIGRFnveIITISMAALFNFVMWLPFGGNT-KVLWAYVCLWGFS 413
Cdd:cd17355 236 YLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRR---LLAASYALRALGLALLLLLPFPpLALLLFAALFGLG 312
|
330 340 350
....*....|....*....|....*....|....
gi 6324453 414 TGSILSLTPVCIGQISKTTDFGKRYATVYLLQAL 447
Cdd:cd17355 313 WGATVPLTAALAARYFGARSYGTLFGLVFAPHQL 346
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
96-488 |
1.10e-24 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 105.34 E-value: 1.10e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 96 AWLVVFGAFMGLVPVFGLINSLGAIESYISKHQlaNISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIY 175
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQADL--GLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 176 AGGLFALANCKSVWQFILAFsVCSGLGTGILMTPLIGTVATWF-LKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQ 254
Cdd:COG2271 86 GLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 255 WAIRILSFICLTCLICAsvlarertkpvvqpfkskaevakwyissvfnwryflegkFLFVAIGASFAESSLTSCATYLAS 334
Cdd:COG2271 165 AAFLILGLPGLLLALLR---------------------------------------FWLLALAYFLVYFALYGFLTWLPT 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 335 Y-SMTRGNTENVAYTMITASNAVGILGRYIPGYFADKFiGRFNVEIITISMAALFNFVMWLPFGGNTKVLWAYVCLWGFS 413
Cdd:COG2271 206 YlVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRL-GRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFG 284
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6324453 414 TGSILSLTPVCIGQISKTTDFGKRYATVYLLQALVTIPVLPIGGTLIgkgTVANYNHFIIFNSALMAAGAACYII 488
Cdd:COG2271 285 LGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL---DATGYQAAFLLLAALALLAALLALL 356
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
95-484 |
1.88e-23 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 101.92 E-value: 1.88e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 95 KAWLVVFGAFMGLVpVFGLINSLGAIESYISKHQlaNISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVI 174
Cdd:cd17353 1 RRWLVLLGAVLMHL-ILGYQYAWSVFNPPLSSAL--GWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 175 YAGGLFALANCKSVWQFILAFSVCSGLGTGILMTPLIGTVATWFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQ 254
Cdd:cd17353 78 FGLGFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 255 WAIRILSFICLTCLICASVLARERTKPVVQPFKSKAEVAKWYISSVFNWRYFLEGKFlFVAIGASFAESSltSCATYLAS 334
Cdd:cd17353 158 TTFLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPRDYTPREMLRTPT-FWLLWLMFFLNA--TAGLMLIG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 335 YSMTRGnTENVAYTMITASNAVGIL------GRYIPGYFADKfIGRFNVEIITISMAALFNFVMwlPFGGNTKVLW-AYV 407
Cdd:cd17353 235 QAKPIG-QEFAGLDAGIAALAVSILsifnggGRPFWGWLSDK-IGRKNTLSIAFLIQGVAMFLL--PFIGSVAVLFvLGV 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6324453 408 CLWGFSTGSILSLTPVCIGQISKTTDFGKRYATVYLLQALvtipvlpigGTLIGKGTVANYNHFIIFNSALMAAGAA 484
Cdd:cd17353 311 ALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGV---------GGLIGPIIAAYVLYTGGYNAAFIIAAAL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
103-450 |
5.21e-23 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 99.80 E-value: 5.21e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 103 AFMGLVPVFGLINSLGAIESYISKHQlaNISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYAGGLFAL 182
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDL--GISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 183 ANCKSVWQFIlAFSVCSGLGTGILMTPLIGTVATWF-LKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQWAIRILS 261
Cdd:pfam07690 80 LFASSLWLLL-VLRVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 262 FICLTCLICASVLARERTKpvvqpfKSKAEVAKWYISSVFNWRYFLEGKFLFVAIGASFAESSLTSCATYLASYSMTRGN 341
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPES------KRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 342 TENVAYTMITASNAVGILGRYIPGYFADKFIGRFNVEIITISMAALFNFVMWLPFGGNTKVLWAYVCLWGFSTGSILSLT 421
Cdd:pfam07690 233 SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPAL 312
|
330 340
....*....|....*....|....*....
gi 6324453 422 PVCIGQISKTTDFGKRYATVYLLQALVTI 450
Cdd:pfam07690 313 NALVSDLAPKEERGTASGLYNTAGSLGGA 341
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
95-485 |
1.40e-22 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 99.57 E-value: 1.40e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 95 KAWLVVFGAFMGLVPVFGLINSLGAIESYISKHQlaNISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVI 174
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEF--GLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 175 YAGGLFALANCKSVWQFiLAFSVCSGLGTGILMTPLIGTVATWFLK-RRGIATSISTMGGSIGGIVFPIMLRKLYKEVGF 253
Cdd:COG2223 80 LGIGLLLLALAVSYWLL-LLLGLLLGIGGGGSFAVGIALVSKWFPPdRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 254 QWAIRILSFICLTCLICASVLARERTKPVVQPFKSKAEVAKWYISSVFNWRYFLegkFLFVAIGASFAESSltscatYLA 333
Cdd:COG2223 159 RNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRFWLLSL---LYFGTFGSFIGFSS------WLP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 334 SYSMTR-GNTENVAYTMITASNAVGILGRYIPGYFADKFiGRFNVEIITISMAALFNFVMWLpFGGNTKVLWAYVCLWGF 412
Cdd:COG2223 230 PYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSDRI-GGRRVLLIVFALMALGLLLLAL-ALGSLWLFLVLFLLLGL 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6324453 413 STGSILSLTPVCIGQISKTTDFGKRYATVYLLQALvtipvlpiGGTLIGKGTVANYNHFIIFNSALMAAGAAC 485
Cdd:COG2223 308 ALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGL--------GGFLGPLLFGALLDATGSYTAAFLVFAVLA 372
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
128-487 |
1.37e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 96.34 E-value: 1.37e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 128 QLANISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYAGGLFALANCKSVWQFILAFSVCsGLGTGILM 207
Cdd:cd06174 24 QSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLL-GLGSGLID 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 208 TPLIGTVATWFLKR-RGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQWaiRILSFICLTCLICASVLARERTKPVVQPF 286
Cdd:cd06174 103 PAVLALIADLFPEReRGRALGLLQAFGSVGGILGPLLGGILASSLGFGW--RAVFLIAAALALLAAILLLLVVPDPPESA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 287 KSKAEVAKWYISSVFNWRYFLEGKFLFVAIGASFAESSLTSCATYLASYSMTRGN-TENVAYTMITASNAVGILGRYIPG 365
Cdd:cd06174 181 RAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGlSVAVAGLLLSLFGLAGALGSLLLG 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 366 YFADKFIGRFNVEIITISMAALFNFVMWLpfGGNTKVLWAYVCLWGFSTGSILSLTPVCIGQISKTTDFGKRYATVYLLQ 445
Cdd:cd06174 261 LLSDRLIGRKPLLLIGLLLMALGLALLLL--APSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFG 338
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 6324453 446 ALVTIPVLPIGGTLIgkGTVANYNHFIIFNSALMAAGAACYI 487
Cdd:cd06174 339 FLGGAIGPLLAGFLL--AATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
97-447 |
8.01e-20 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 90.80 E-value: 8.01e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 97 WLVVFGAFMGLVPVFGLINSLGAIESYIskhqlaNISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYA 176
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALPLIAADL------GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 177 GGLFALANCKSVWQFILAfSVCSGLGTGILMTPLIGTVATWF-LKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQW 255
Cdd:COG2814 87 LGSLLCALAPSLWLLLAA-RFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 256 AIRILSFICLTCLICASVLARERTKPVVQPFKSKAevakwyissvfnWRYFLEGKFLFVAIGASFAESSLTSCATYLASY 335
Cdd:COG2814 166 VFLVNAVLALLALLLLLRLLPESRPAARARLRGSL------------RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLY 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 336 SMTRGNTENVAYTMITASNAVG-ILGRYIPGYFADKFiGRFNVeiITISMAALFNFVMWLPFGGNTKVLWAYVCLWGFST 414
Cdd:COG2814 234 LQEVLGLSASAAGLLLALFGLGgVLGALLAGRLADRF-GRRRL--LLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGF 310
|
330 340 350
....*....|....*....|....*....|...
gi 6324453 415 GSILSLTPVCIGQISKTTDFGKRYATVYLLQAL 447
Cdd:COG2814 311 GLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
95-447 |
4.59e-19 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 89.16 E-value: 4.59e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 95 KAWLVVFGAFMGLVPVFGLINSLGAIESYISkHQLAnISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVI 174
Cdd:COG2807 15 GRWLLLLAIVLVALNLRPAITSVGPLLPEIR-ADLG-LSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 175 YAGGLFALANCKSVWQFiLAFSVCSGLGTGILMTPLIGTVATWFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQ 254
Cdd:COG2807 93 LAAGLLLRSLAPSVALL-LAGTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWR 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 255 WAIRILSFICLTCLICASVLARERTKPvvqpfkSKAEVAKWYISSVFNWRyflegkfLFVAIGASFAESSL--TSCATYL 332
Cdd:COG2807 172 GALAVWALLALLALLLWLPLLRRRPAA------AAAAPAAASLRSLWRSP-------LAWLLTLFFGLQSLlyYAVVAWL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 333 ASYSMTRGNTENVAYTMITASNAVGILGRYIPGYFADKFIGRFNVEIITISMAALFNFVMWLPFGGntkVLWAYVCLWGF 412
Cdd:COG2807 239 PPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGS---LPWLWAVLLGL 315
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 6324453 413 STGSILSLTPVCIGQISKTT-DFGKRYATV----YLLQAL 447
Cdd:COG2807 316 GQGGLFPLALTLIGLRARTPaEAAALSGMAqsvgYLLAAL 355
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
97-457 |
6.36e-19 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 88.62 E-value: 6.36e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 97 WLVVFGAFMGLVPVFGLINSLGAIESYISKHqlANISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYA 176
Cdd:cd17314 2 WFVLYVSFLLSAMSTGFILSWSLFYQPWQDA--FGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 177 GGLFALANCKSVWQFILAFSVCSGLGTGILMTPLIGTVATWFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQWA 256
Cdd:cd17314 80 AGYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 257 IRILSFICLTCLICASVLaRERTKPVVQpfKSKAEVAKWYISSVFNWR------------YFLEGKFLFVAIGASFAESS 324
Cdd:cd17314 160 YTILGILAAIVLSVVSLL-GFKEPPDNQ--ARLHVQKKKTQTMGEIFRdkvfwilfiaifLVLIGGFLFIANMASLVRSL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 325 ltscatylasysmtRGNTENVAYTMITASNAVGILGRYIPGYFADKFIGRFNVEIITISMAALFNFVMWLPFGGNTKVLW 404
Cdd:cd17314 237 --------------QLDAPSFVTKLMSIYGLFNAFGRLLWGIVADFFGGRLSTLSILLTILGLGLCAFLFLLKMTPVGLV 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 6324453 405 AYVCLWGFSTGSILSLTPVCIGQISKTTDFGKRYATVYLLQALVTIPVLPIGG 457
Cdd:cd17314 303 LTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGA 355
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
97-450 |
2.59e-17 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 83.60 E-value: 2.59e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 97 WLVVFGAFMGLVPVFGLINSLGAIesYISKHQLANISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYA 176
Cdd:cd17423 2 WVVVLAAFLQNALVFGVLRSFGVF--FVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 177 GGLFALANCKSVWQFILAFSVCSGLGTGILMTPLIGTVATWFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQWA 256
Cdd:cd17423 80 LGFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 257 IRILSFICLTCLICASVLARERTKPV-VQPFKSkaevakwyISSVFNWRYFLEGKFLFVAIGASFAESSLTSCATYLASY 335
Cdd:cd17423 160 LLLLSALSLHLVPCGALLRPLALPGDpPAPPRS--------LSAAFGLSLLTHRAFLRYALATTLINTGYFIPYVHLVAH 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 336 SMTRGNTENVAYTMITASNAVGILGRYIPGYFADKFIGRfnveiiTISMAALFN-----FVMWLPFGGNTKVLWAYVCLW 410
Cdd:cd17423 232 ARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLR------LLHLLVLWTaltglSLLLLPLAKVYGSLLALAVAY 305
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 6324453 411 GFSTGsilSLTPVCIGQISKTTDFGKRYATVYLLQALVTI 450
Cdd:cd17423 306 GFCAG---ALAPLVFSVLPELVGVERVLNATGLLQMIESV 342
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
96-420 |
6.89e-16 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 79.50 E-value: 6.89e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 96 AWLVVFGAFMGLVPVFGLINSLGAIESYIS---KHQLANISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGT 172
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLerlTKLGDPEASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 173 VIYAGGLFALANCKSVWQFILAFSVCSGLGTGILMTPLIGTVATWFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVG 252
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 253 FQWAIRILSFICLTCLICAsvLARERTKPVVQPFKSKAEVAKW------YISSVFNWRYFLEGKFLFVAIGASFAESSLT 326
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCS--FTYRPLHPSPEDPKSKPGRRTLhsrinlFLRKIFNVEIFKRKRYVIWALGIPLALFGYF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 327 SCATYLASYSMTRGNTENVAYTMITASNAVGILGRYIPGYFADKFIGRFNVEIITISMAALFNFVMWLPFGGNTKVLWAY 406
Cdd:cd17420 239 VPYVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADMPPGVKKMYLQVLSFVSIGLMSMMIPLCNSFGILISV 318
|
330
....*....|....
gi 6324453 407 VCLWGFSTGSILSL 420
Cdd:cd17420 319 CLVMGLFDGCFISI 332
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
97-490 |
3.47e-14 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 74.15 E-value: 3.47e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 97 WLVVFGAFMG---LVPVFGL-INSLGAiesyiskhqlaniSSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGT 172
Cdd:cd17325 2 SLALFLDMLGygiIIPILPLyAESLGA-------------SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGL 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 173 VIYAGGLFALANCKSVWQFILAfSVCSGLGTGILMTPLIGTVA-TWFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEV 251
Cdd:cd17325 69 LLLAVSTLLFAFATSYWQLLLA-RFLQGLASAAVWPAAMALIAdIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 252 GFQWAIRILSFICLTCLICASVLARERTKPVVQPFKSKAEVAKWYISSVFNWRYFLegkfLFVAIGASFAesSLTSCATY 331
Cdd:cd17325 148 GYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLA----LFLAIFVLAF--AFGALEPF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 332 LASYSMTRGNTENVAYTMI-TASNAVGILGRYIPGYFADKFiGRfnVEIITISMAALFNFVMWLPFGGNTKVLWAYVCLW 410
Cdd:cd17325 222 LPLYAAELGGLSPAQIGLLfGAQGLASALSQPPAGKLSDRI-GR--KPLILIGLLLSAVALLLLPLATSFWLLLLLLALL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 411 GFSTGSILSLTPVCIGQISKTTDFGKRYATVYLLQALVTipvlpIGGTLIGkGTVANYNHF---IIFNSALMAAGAACYI 487
Cdd:cd17325 299 GLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGM-----VLGPLLG-GFLYDAFGFatpFLAAAALLLLAAVLFL 372
|
...
gi 6324453 488 ISR 490
Cdd:cd17325 373 LLR 375
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
90-493 |
1.76e-13 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 72.47 E-value: 1.76e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 90 PDGGLkAWLVVFGAFMGLVPVFGLINSLGAIESYIskHQLANISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMC 169
Cdd:TIGR00892 12 PDGGW-GWVVLGATFVSIGFSYAFPKAVTVFFKEL--QQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 170 TGTVIYAGGLFALANCKSVWQFILAFSVCSGLGTGILMTPLIGTVATWFLKRRGIATSISTMGGSIGGIVFPIMLRKLYK 249
Cdd:TIGR00892 89 AGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFE 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 250 EVGFQWAIRILSFICLTCLICASVLARERTKPVVQPFKSK------------AEVAKW-YISSVFNWRYFLEGKFLFVAI 316
Cdd:TIGR00892 169 SFGWRGSFLILGGLLLHCCVCGALMRPVGPSQRVSKSKSKeglppdgstkklSKKSTAeKINRFLDFSLFTHRGFLVYLS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 317 GASFAESSLTSCATYLASYSMTRGNTENVAYTMITASNAVGILGRYIPGYFADKFIGRFNVEIItISMAALFNFVMWL-- 394
Cdd:TIGR00892 249 GNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKWIRPHVQYL-FSFALLFNGLTHLlc 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 395 PFGGNTKVLWAYVCLWGFSTGSILSLTPVCIGQISKTTDFGKRYATVYLLQALvtiPVLpIGGTLIGK--GTVANYNHFI 472
Cdd:TIGR00892 328 ALAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECC---AVL-IGPPLAGRlvDATKNYKYIF 403
|
410 420
....*....|....*....|.
gi 6324453 473 IFNSALMAAGAACYIISRHIC 493
Cdd:TIGR00892 404 YASGSIVVSAGLFLAIGNYIN 424
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
69-269 |
2.84e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 67.99 E-value: 2.84e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 69 VTSRVLNTPEASLIYDDDREFPDGGLKAWLVVFGAFMGLVPVFGLIN-SLGAIESYISKH--QLANISSSTISWIFSLYL 145
Cdd:cd17325 166 LALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAfAFGALEPFLPLYaaELGGLSPAQIGLLFGAQG 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 146 AISFLSCILSGGYFDRNGSIGLMCTGTVIYAGGLFALANCKSVWQFILAFSVCsGLGTGILMTPLIGTVATWFLKR-RGI 224
Cdd:cd17325 246 LASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALL-GLGLGLVFPATLALLADIVPPEgRGT 324
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 6324453 225 ATSISTMGGSIGGIVFPIMLRKLYKEVGFQWAIRILSFICLTCLI 269
Cdd:cd17325 325 AMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAV 369
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
97-490 |
3.31e-12 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 67.85 E-value: 3.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 97 WLVVFGAFMGLVPVFGLINSLGAIESYISKHqlANISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYA 176
Cdd:cd17422 2 WAVAVAFFFVEVFTYGVIKSFGVFFNDLMSY--FNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLIS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 177 GGLFALANCKSVWQFILAFSVCSGLGTGILMTPLIGTVATWFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQWA 256
Cdd:cd17422 80 LGMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYC 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 257 IRILSFICLTCLICASVLarertkpvvqpfkskaevakwyissvfnwRYFLEGKFLFVAIGASFAESSLTSCATYLASYS 336
Cdd:cd17422 160 LLVVGALQLNIVVCGALL-----------------------------RVLKEPGFICYALFGLFATLGFFAPQLYIIPLS 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 337 MTRGNTENVAYTMITASNAVGILGRYIPGYFADKFIGRfNVEIITISMAALFNFVMWLPFGGNTKVLWAYVCLWGFSTGS 416
Cdd:cd17422 211 LSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPIR-KIYIELICVILLCVVLLLFPFAYGFWSLLVCSIFYGFMFGT 289
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6324453 417 ILS--LTPVCIGQISKTTDFGKRYATVYLLQALVTIPVLPIGGTLIgkGTVANYNHFIIFNSALMAAGAACYIISR 490
Cdd:cd17422 290 VAGthIPLLAEDDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLV--DWTQNYGSAFYSCAAGMALGAVFLALVR 363
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
99-428 |
3.38e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 65.31 E-value: 3.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 99 VVFGAFMGLVPVFgLINSLGaiesyiskhqlanISSSTISWIFSLYLAISFLSCILSGGYFDRNGS-----IGLMCTGTV 173
Cdd:COG2211 24 LAFGLLSAYLLYF-YTDVLG-------------LSAALVGLILLVARLWDAITDPLIGALSDRTRTrwgrrRPWILIGAI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 174 IYAGGLFALANCKSVWQ-----FILAFSVCSGLGTGILMTPLIGTVATWF--LKRRGIATSISTMGGSIGGIVFPIMLRK 246
Cdd:COG2211 90 PLALSFVLLFTAPDLSPtgkliYALVTYLLLGLAYTLVNIPYSALGAELTpdYEERTRLSSWRFAFAGLGGLLASVLPPP 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 247 LYKEV------GFQWAIRILSFICLTCLICASVLARERTKPVVQPFKSKAEvakwyISSVFNWRYFLegKFLFVAIGASF 320
Cdd:COG2211 170 LVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKES-----LKALLKNRPFL--LLLLAYLLFFL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 321 AESSLTSCATYLASYSMtrGNTENVAYTMITASNAVGILGRYIPGYFADKFiGRFNVEIITISMAALFNFVMWLPFGGNT 400
Cdd:COG2211 243 ALALVAALLLYYFKYVL--GLSAALVGLLLALYFLAALLGAPLWPRLAKRF-GKKKAFIIGLLLAALGLLLLFFLGPGNL 319
|
330 340
....*....|....*....|....*...
gi 6324453 401 KVLWAYVCLWGFSTGSILSLTPVCIGQI 428
Cdd:COG2211 320 WLLLVLAALAGIGLGAILVLPWAMLADV 347
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
96-274 |
8.17e-11 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 63.70 E-value: 8.17e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 96 AWLVVFGAFMGLVPVFGLINSLGAIesYISKHQLANISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIY 175
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGIL--NMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 176 AGGLFALANCKSVWQFILAFSVCSGLGTGILMTPLIGTVATWFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQW 255
Cdd:cd17429 79 SLGWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRN 158
|
170
....*....|....*....
gi 6324453 256 AIRILSFICLTCLICASVL 274
Cdd:cd17429 159 AMFIQGAVSLNLCVCGALM 177
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
97-419 |
1.01e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 63.38 E-value: 1.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 97 WLVVFGAFMGlvpvFGLINSLGAIesYIskHQLaNISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYA 176
Cdd:cd17489 2 LLANFFFFLS----FYLLLPVLPL--YA--HDL-GGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 177 GGLFALANCKSVWQFiLAFSVCSGLGTGILmTPLIGTVATWFL--KRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQ 254
Cdd:cd17489 73 LATLLYLLATSVALL-LVLRLIHGIGWGAF-TTAAATLVADIIppSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 255 WAIRILSFICLTCLICASVLARERTKPVVQPFKSKaevakwyissvFNWRYFLEGKFLFVAIGASFAESSLTSCATYLAS 334
Cdd:cd17489 151 VLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGT-----------RAFRRLVEKKVLPPALILFLASIAYGAISTFLPL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 335 YSMTRGNTENVAYTMITAsnAVGILGRYIPGYFADKFiGRFNVEIITISMAALFNFVMWLPfGGNTKVLWAYVcLWGFST 414
Cdd:cd17489 220 YAAERGISNAGLFFTVYA--IALLLSRPFSGKLSDRK-GPKTVIIPGLLLLALGLLLLSFA-GSPWMLLLAAV-LYGLGF 294
|
....*
gi 6324453 415 GSILS 419
Cdd:cd17489 295 GLLFP 299
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
92-280 |
1.06e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 63.35 E-value: 1.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 92 GGLKAWLVVFGAFMGLVPVFGLINSLGaieSYIskHQLANISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIG--LMC 169
Cdd:COG2271 178 ALLRFWLLALAYFLVYFALYGFLTWLP---TYL--VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLA 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 170 TGTVIYAGGLFALANCKSVWQFILAFSVCsGLGTGILMTPLIGTVATWF-LKRRGIATSISTMGGSIGGIVFPIMLRKLY 248
Cdd:COG2271 253 IGLLLAALALLLLALLPSPALAIALLFLA-GFGLGGAFGLLWALAAELFpKKARGTASGLVNTFGFLGGALGPLLVGYLL 331
|
170 180 190
....*....|....*....|....*....|..
gi 6324453 249 KEVGFQWAIRILSFICLTCLICASVLARERTK 280
Cdd:COG2271 332 DATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
131-423 |
1.30e-10 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 62.96 E-value: 1.30e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 131 NISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYAGGLFALANCKSVWqFILAFSVCSGLGTGILMTPL 210
Cdd:cd17478 27 GLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYW-LLLLLVALAGIGSAAFHPEG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 211 IGTVATWFLKRRGIATSISTMGGSIGGIVFPIMLRKLykeVGFQWAIRILSFICLTCLICASVLARERTKPVVQPfKSKA 290
Cdd:cd17478 106 ARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAAL---VALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEA-KKAA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 291 EVAKWYISSVFNWRyflegKFLFVAIGASFAESSLTSCATYLASYSMTRGNTENVAYTMITASNAVGILGRYIPGYFADK 370
Cdd:cd17478 182 AKSSARSTLKGVWR-----ALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDR 256
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 6324453 371 FiGRFNVEIITISMAALFNFVMWLpfggnTKVLWAYVCLW--GFSTGSILSLTPV 423
Cdd:cd17478 257 F-GRRRVIIASLLLAAPFLLLFLL-----TPGIWSYILLVlaGFLLFASFPVTVV 305
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
97-281 |
2.99e-09 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 58.74 E-value: 2.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 97 WLVVFGAFMGLVPVFGLINSLGAIESYISKhqLANISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYA 176
Cdd:cd17426 2 WAVVLGAFISIGFSYAFPKSITVFFKEIEV--IFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 177 GGLFALANCKSVWQFILAFSVCSGLGTGILMTPLIGTVATWFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQWA 256
Cdd:cd17426 80 AGLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGS 159
|
170 180
....*....|....*....|....*
gi 6324453 257 IRILSFICLTCLICASVLARERTKP 281
Cdd:cd17426 160 FLILGGLLLNCCVAGSLMRPIGPKP 184
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
171-460 |
3.45e-09 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 58.67 E-value: 3.45e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 171 GTVIYAGGLFALANCKSVWQFILAFSVCSGLGTGILMTPLIGTVATWFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKE 250
Cdd:cd17424 74 GGLLASTGLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQ 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 251 VGFQWAIRILSFICLTCLICASVLarertkpvvqpfkskaevakwyissvfnwRYFLEGKFLFVAIGASFAESSLTSCAT 330
Cdd:cd17424 154 FSWRGALLILGGFVLNLCVCGALM-----------------------------RFLLMPDFLVLAVSVLFLAYGCSPPFV 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 331 YLASYSMTRGNTENVAYTMITASNAVGILGRYIPGYFADKFI---GRFNVEIITISMAALfnFVMWLPFGGNTKVLWAYV 407
Cdd:cd17424 205 YLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRClkkYRYFCYLFAVGMDGL--CCLFLPILKTFPLLVPFS 282
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 6324453 408 CLWGFSTGSILSLTPVCIGQISKTTDFGKRYATVYLLQALVTIPVLPIGGTLI 460
Cdd:cd17424 283 FTFGYFDGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLV 335
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
94-417 |
4.61e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 58.33 E-value: 4.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 94 LKAWLVVFGAFMglvpVFGLI-NSLGAIESYISKHqlANISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGT 172
Cdd:COG0738 7 RRALIAIYLLFF----LWGFAtALWGPLIPALKDA--FGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 173 VIYAGGLFALANCKSVWQFILAFsVCSGLGTGILMTPLIGTVATWFLKRRGIATSISTMGGSIGGIVFPIM---LRKLYK 249
Cdd:COG0738 81 LLMALGLLLFALAPSYPLLLLAL-FLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLgglLILLGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 250 EVGFQWAIRILSFICLTCLICASVLARERTKPVVQPFKSKAEVAKwyisSVFNWRYFLEGkfLFVAIGASFAEsslTSCA 329
Cdd:COG0738 160 SLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLK----SLLKNPRLLLG--GLAIFLYVGAE---GAIG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 330 TYLASY-SMTRGNTENVAYTMITASNAVGILGRYIPGYFADKFiGRFNVEIITISMAALFNFVMWlpFGGNTKVLWAYVC 408
Cdd:COG0738 231 DWLPLYlKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF-GPVRLLRLSALLAAVGLLLAL--LAPGPWLALIGLA 307
|
....*....
gi 6324453 409 LWGFSTGSI 417
Cdd:COG0738 308 LVGLGLSLM 316
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
97-420 |
1.62e-08 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 56.36 E-value: 1.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 97 WLVVFGAFMGLVPVFGLINSLGAIESYIskHQLANISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYA 176
Cdd:cd17427 2 WAVVFGAFISIGFSYAFPKAITVFFKEI--QEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 177 GGLFALANCKSVWQFILAFSVCSGLGTGILMTPLIGTVATWFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQWA 256
Cdd:cd17427 80 LGMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 257 IRILSFICLTCLICASVLarertKPVVQPFKSKAevakwyissvfnwryflegkFLFVAIGASFAESSLTSCATYLASYS 336
Cdd:cd17427 160 FLILGGLLLNCCVAGSLM-----RPLGPLFKHRG--------------------FLIYLSGNVIMFLGFFAPIVFLAPYA 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 337 MTRGNTENVAYTMITASNAVGILGRYIPGYFADKFIGRFNVEIItISMAALFNFVMWL--PFGGNTKVLWAYVCLWGFST 414
Cdd:cd17427 215 KHMGIDEYSAAFLLSILAFVDMFARPSMGLVANSKWIRPRIQYF-FSFAVMYNGVCHLlcPLAEDYTGLVIYAVFFGFAF 293
|
....*.
gi 6324453 415 GSILSL 420
Cdd:cd17427 294 GMVSSV 299
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
150-413 |
3.70e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 55.32 E-value: 3.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 150 LSCILSGGYFDRNGSIGLMCTGTVIYAGGLFALANCKSVWqFILAFSVCSGLGTGIlMTPLIGT-VATWFLKR-RGIATS 227
Cdd:cd17475 46 VSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYP-VLLVLLFLVGAGYGS-VQPGGGRaIMRWFPPReRGLAMG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 228 ISTMGGSIGGIVFPIMLRKLYKEVGFQWAIRILSFICLTCLICASVLARERTKPVVQPFKSKAEVA--KWYISSVFNWRY 305
Cdd:cd17475 124 IRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASAATESASTLLRslKEVLRNRDVWLI 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 306 FLEGKFLfvaIGASFAESsltscaTYLASYSM-TRGNTENVAYTMITASNAVGILGRYIPGYFADKFIG--RFNVEIITI 382
Cdd:cd17475 204 AIAGALL---VAPQFALL------TFLLLFLHdHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGgrRRPVLVITA 274
|
250 260 270
....*....|....*....|....*....|..
gi 6324453 383 SMAALFNFVMWLPFGGNTKVLWAYVCLW-GFS 413
Cdd:cd17475 275 AIAAAALLVLSLLSPGTPLWLLVLLLILlGLF 306
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
127-408 |
3.94e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 55.31 E-value: 3.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 127 HQLANISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYAGGLFALANCKSVWQFILAFsVCSGLGTGIL 206
Cdd:cd17329 27 HQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIAL-VLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 207 MTP---LIGTVATwfLKRRGIATSISTMGGSIGGIVFPIMLRKLYkEVGFQWAIRILSficLTCLICASVLARERTKPVV 283
Cdd:cd17329 106 EPAseaMIADVTT--PENRTRAFSLLYWAINLGVAIGPLLGGLLL-LYSFRLLFLAAA---VLFLLAALVLLFLLPETRP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 284 QPFKSKAEVAKWYISSVFNWRYFLegKFLFVAIGASFAESSLTScatYLASYSMTRGNTENVAYTMITASNAVGILgryI 363
Cdd:cd17329 180 KRRAAEKTEILRGYKIVLRDRAFL--LFLLASFLISLIYFQLES---TLPVYVVEILGLGESLLGLLLALNALLIV---L 251
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 6324453 364 PGYFADKFIGRFNveIITISMAALFNFVMWLPFGGNTKVLWAYVC 408
Cdd:cd17329 252 LQFPVARLVERFR--LRKILMIGILLFAIGFAVLAFANTLAVLIL 294
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
133-460 |
1.57e-07 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 53.24 E-value: 1.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 133 SSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYAGGLFALANCKSVWQFILAFSVCSGLGTGILMTPLIG 212
Cdd:cd17425 36 SNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGVGMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVT 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 213 TVATWFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQWAIRILSFICLTCLICASVLarertkpvvQPFKSkaev 292
Cdd:cd17425 116 VLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSFLVFGGVLLNCCVCGAVM---------RPFCS---- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 293 akwyissvfNWRYFLegkflfVAIGASFAESSLTSCATYLASYSMTRGNTENVAYTMITASNAVGILGRYIPGYFADK-- 370
Cdd:cd17425 183 ---------NTRYQI------YTLGVTWMVLGFVLPLIYLVPYATSNGMDESKAALLLSILGFINIFMRPLAGLLSGLpv 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 371 FIGRfnvEIITISMAALFNFVMWL--PFGGNTKVLWAYVCLWGFSTGSILSLTPVCIGQISKTTDFGKRYATVYLLQALV 448
Cdd:cd17425 248 FKGR---RIYLFSLALLLNGLSNLicAISASFPVLLVYCLLYSISMSGIGSLIFQVLMDTVEMDRFPSALGLFTILESVT 324
|
330
....*....|..
gi 6324453 449 TIPVLPIGGTLI 460
Cdd:cd17425 325 ILIGPPLAGLLV 336
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
131-427 |
2.02e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 52.95 E-value: 2.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 131 NISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYAGGLFALANCKSVWqFILAFSVCSGLGTGILMTpl 210
Cdd:cd17477 27 GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPW-VWFLLRFVMGIGLAGLFV-- 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 211 igTVATWFL-----KRRGIATSISTMGGSIGGIVFPIMLRkLYKEVGFQWairilsFICLTCLICASVLARERTKPVVQP 285
Cdd:cd17477 104 --VSESWLNalatnENRGRVLGLYSTVLGLGFALGPLLLA-LVGTAGALP------FLIAAVLLLLALVPLLLTRRAAPE 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 286 FKSKAEVAkwyissvfNWRYFLEGKFLFVAIGAS-FAESSLTScatYLASYSMTRGNTENVAYTMITASNAVGILGRYIP 364
Cdd:cd17477 175 IEEAESIS--------LRRLLRIAPLALLGAFVAgFLEGAFYS---LLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPL 243
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6324453 365 GYFADKFiGRFNVEIITISMAALFNFVMWLpFGGNTKVLWAYVCLWGFSTGSILSLTPVCIGQ 427
Cdd:cd17477 244 GWLADRF-DRRRVLLGCALLGALAALLLPL-VPGLPLALLVLLFLWGGAAGPLYTLALALAGD 304
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
97-274 |
3.93e-07 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 52.12 E-value: 3.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 97 WLVVFGAFMGLVPVFGLINSLGAIesYISKHQLANISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYA 176
Cdd:cd17428 2 WVIVFVSFLAQFLCYGSPLAVGVL--YPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 177 GGLFALANCKSVWQFILAFSVCSGLGTGILMTPLIGTVATWFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQWA 256
Cdd:cd17428 80 GGLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGC 159
|
170
....*....|....*...
gi 6324453 257 IRILSFICLTCLICASVL 274
Cdd:cd17428 160 LLIVGALALNLLACGSLM 177
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
97-237 |
3.99e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.90 E-value: 3.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 97 WLVVFGAFMGLVPVFGLINSLGAIEsyiskHQLANISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYA 176
Cdd:COG2814 210 LLLLLLAFLLGFGFFALFTYLPLYL-----QEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLA 284
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6324453 177 GGLFALANCKSVWQFILAFSVCsGLGTGILMTPLIGTVATWF-LKRRGIATSISTMGGSIGG 237
Cdd:COG2814 285 LGLLLLALAGSLWLLLLALFLL-GFGFGLLFPLLQALVAELApPEARGRASGLYNSAFFLGG 345
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
99-243 |
1.37e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 50.25 E-value: 1.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 99 VVFGAFMGLVPVFGLINSLGAIESYIskhqlaNISSSTISWIFSLYlAISFLSCILSGGYF-DRNGSIGLMCTGTVIYAG 177
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDL------GASPSQLQWVVNAY-LLAFAALLLLAGRLgDRFGRKRVFLIGLALFGL 73
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6324453 178 G--LFALANckSVWQFIlAFSVCSGLGTGILMTPLIGTVATWF-LKRRGIATSISTMGGSIGGIVFPIM 243
Cdd:cd17321 74 AslLCALAP--SLAFLI-AARALQGIGAAAIMPASLALIAATFpGERRGRALGLWGAVVGIGAALGPLL 139
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
97-261 |
6.10e-06 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 48.25 E-value: 6.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 97 WLVVFGAFMGLVPVFGLINSLGAIESYISKHQLANISSST---ISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTV 173
Cdd:cd17465 2 WVVVFAATWCNGSIFGIQNSFGILYVMLLNEQEDQKDQAVqfkTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 174 IYAGGLFALANCKSVWQFILAFSVCSGLGTGILMTPLIGTVATWFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGF 253
Cdd:cd17465 82 VAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIGL 161
|
....*...
gi 6324453 254 QWAIRILS 261
Cdd:cd17465 162 AHTFQVLS 169
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
116-256 |
8.53e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.97 E-value: 8.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 116 SLGAIESYISKHqLANISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYAGGLFALANCKSVWQFILAF 195
Cdd:cd17489 209 AYGAISTFLPLY-AAERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAA 287
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6324453 196 SVCsGLGTGILMTpligTVATWFLK-----RRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQWA 256
Cdd:cd17489 288 VLY-GLGFGLLFP----ALQALAVDlvpphRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAM 348
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
94-275 |
2.67e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 46.41 E-value: 2.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 94 LKAWLVVFGAFMGLVPVFGLINSLGaieSYISKHQLAniSSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTV 173
Cdd:cd17473 197 KRVLPIYFLAFLAMLLFYVIPIQLP---FLLQERGGG--SAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFA 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 174 IYAGGLFALANCKSVWQFILAfSVCSGLGTGILMTPLIGTVATWF-LKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVG 252
Cdd:cd17473 272 LMALGFLLLALASGLWVVLLG-AILAGLGFGLLLPTLNSWAMSLVpPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTG 350
|
170 180
....*....|....*....|...
gi 6324453 253 FQWAirILSFICLTCLICASVLA 275
Cdd:cd17473 351 GLSG--AFLILGVLALVLAIVLL 371
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
97-261 |
4.38e-05 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 45.94 E-value: 4.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 97 WLVVFGAFMGLVPVFGLINSLGA-----IESYISKHQlANISSSTiSWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTG 171
Cdd:cd17464 2 WVVMLAAMWCNGSVFGIQNAFGVlfvslLEEFGSKDD-AQMRFKT-AWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 172 TVIYAGGLFALANCKSVWQFILAFSVCSGLGTGILMTPLIGTVATWFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEV 251
Cdd:cd17464 80 AAVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSV 159
|
170
....*....|
gi 6324453 252 GFQWAIRILS 261
Cdd:cd17464 160 GLFNTLRVLC 169
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
100-425 |
7.61e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.90 E-value: 7.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 100 VFGAFMGLVPVFGLINSLGAIESYISKHQLANISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYAGGL 179
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 180 FALANCKSVWQFILaFSVCSGLGTGilmtPLIGTVATWFL-----KRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQ 254
Cdd:cd17316 81 LLIGLLPTPILLLV-LRFLQGIGIG----GEYPGASTYVAefapsKRRGFALGLLQSGWALGALLAALVASLLIPLLSGD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 255 WAIRILSFICLtCLICASVLARERTkpvvqpfkskaevakwyissvfnwryflegkfLFVAIGASFAESSLTSCATYLAS 334
Cdd:cd17316 156 WGWRILFLIGA-LPALLALLLRRRT--------------------------------LLLILLWFFISFGYYGLTTFLPT 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 335 Y-SMTRGNTENVAYTMITASNAVGILGRYIPGYFADKfIGRFNVEIITISMAALFNFVMWLPFGGNTKVLWAYVCLWGFS 413
Cdd:cd17316 203 YlQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDR-IGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFF 281
|
330
....*....|..
gi 6324453 414 TGSILSLTPVCI 425
Cdd:cd17316 282 VGGVWGALYAYL 293
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
110-388 |
8.66e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 44.62 E-value: 8.66e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 110 VFGLINSLGAIeSYISKHQLANISSSTISWIFSLyLAISFLSCILSGGYF-DRNGSIGLMCTGTVIYAGGLFALANCKSV 188
Cdd:cd17333 7 SNGLTDALLGI-LGPSLEEAFNLNVADVSVIFSS-QNAGYLIGSLLAGFLmKRLGRRRTLILGLLLISLALALIFATPSI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 189 WqFILAFSVCSGLGTGILMTPLIGTVATWFLKRRGIATSISTMGGSIGGIVFP-IMLRKLYKEVGFQWA---IRILSFIC 264
Cdd:cd17333 85 Y-LFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPlIATSLLTSELSWSWAyliIGLIYLLL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 265 LTCLICASVLARERTKPVVQPFKSKAEVAkwyISSVFNWRYFLEGKFLFVAIGAsfaessLTSCATYLASYSM-TRGNTE 343
Cdd:cd17333 164 AILILLTLFPELPSARNPQQSVGAFSASA---SRLLRNPSIILGALALFLYVGA------ETAFSSWVPSYLVeKKHVSD 234
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 6324453 344 NVAYTMITASNAVGILGRYIPGYFADKF-IGRFNVEIITISMAALF 388
Cdd:cd17333 235 GLAGYLLSGFWVGITIGRLLGGPISRRIkPHTLLVLSGSGALLGLL 280
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
99-242 |
1.29e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 44.10 E-value: 1.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 99 VVFGAFMGLVPVFGLINSLGAIESYIskhqlaNISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYAGG 178
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDL------GASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLG 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6324453 179 LFALANCKSVWQFILaFSVCSGLGTGILMTPLIGTVATWF-LKRRGIATSISTMGGSIGGIVFPI 242
Cdd:cd17503 75 SLLCGLAPNLASLII-FRILQGFGGGVLIPLAQTILLRIYpPEKRGAAMGLVGLVILLAPAIGPT 138
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
131-321 |
1.43e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 43.65 E-value: 1.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 131 NISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYAGGLFALANCKSVWQFIlAFSVCSGLGTGILMTPL 210
Cdd:COG0477 45 GASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLI-AARALQGIGAGGLMPGA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 211 IGTVATWF-LKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQWAIRILSFICLTCLICASVLARERTKPVVQPFKSK 289
Cdd:COG0477 124 LALIAELFpARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALAL 203
|
170 180 190
....*....|....*....|....*....|..
gi 6324453 290 AEVAKWYISSVFNWRYFLEGKFLFVAIGASFA 321
Cdd:COG0477 204 AALLLAALALALLALLLLLLLLLLALLALLLA 235
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
133-239 |
1.56e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.09 E-value: 1.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 133 SSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYAGGLFALANCK---SVWQFILAFSVCsGLGTGILMTP 209
Cdd:cd17321 202 SPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGadsSVWLLLPGLVLL-GLGLGLFATP 280
|
90 100 110
....*....|....*....|....*....|.
gi 6324453 210 LIGT-VATWFLKRRGIATSISTMGGSIGGIV 239
Cdd:cd17321 281 LTNAaLSSVPKEKAGAASGILNTARQLGGAL 311
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
95-271 |
1.85e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 43.67 E-value: 1.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 95 KAWLVVFGAFMGLVPVFGLINSLGAieSYISKHqlANISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTV- 173
Cdd:cd17369 228 RALLLAIGLRLAENVLFYLFTTFAL--SYATQT--LGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALl 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 174 --IYAGGLFALANCKSVWQFILAFSVCSGLGTGILMTPLIGTVATWFLKR-RGIATSIST-MGGSIGGIVFPIMLRKLYK 249
Cdd:cd17369 304 aaLFAFPFFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRvRYTGASLGYqLGAILGGGFAPLIATALVA 383
|
170 180
....*....|....*....|..
gi 6324453 250 EVGFQWAIRIlsFICLTCLICA 271
Cdd:cd17369 384 ATGSWWPVAL--YLAALAVISL 403
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
131-488 |
3.00e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 42.94 E-value: 3.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 131 NISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYAGGLFALANCKSVWQFILAfSVCSGLGTGILMTPL 210
Cdd:cd17319 34 GLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVL-RFLLGVAEAGFFPGA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 211 IGTVATWF-LKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQWAirilsFICLTCLicASVLArertkpvvqpfksk 289
Cdd:cd17319 113 IKALAEWFpARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWA-----FIIEGLL--GLLLA-------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 290 aevakwyissVFNWRYFleGKFLFVAIGASFAESSLTSCATYLASYSMTRGNTENVAYTMITASNAV-GILGRYIPGYFA 368
Cdd:cd17319 172 ----------VLWWFYL--RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLaGAIGMILGGRLS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 369 DKFIGRFNVEIITISMAALFNFVMWLPFGGNtkvLWAYVCLWGFSTGSILSLTPVCIGQISKTTDfGKRYATVYLLQALv 448
Cdd:cd17319 240 DRLLRGARRLVIIIGLLLAAVGLLLAYLTTS---PVVAVILLSLAGFGIGAASPVFWSLPADLLP-GEAAATAGGLINS- 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 6324453 449 tipVLPIGG----TLIG--KGTVANYNHFIIFNSALMAAGAACYII 488
Cdd:cd17319 315 ---GGNLGGfvapLLIGylVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
127-280 |
3.36e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 42.92 E-value: 3.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 127 HQLANISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYAGGLFALANCKSVWQFILAFsVCSGLGTGIL 206
Cdd:COG0738 238 KDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGL-ALVGLGLSLM 316
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6324453 207 MTPLIGTVATWFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQWAIRILSFICLTCLICASVLARERTK 280
Cdd:COG0738 317 FPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRK 390
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
87-241 |
3.80e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.79 E-value: 3.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 87 REFPDGGLKAWLVVFG--AFMGLVPVFGLINSLGAIESYISKHQ-LANISSSTISWIFSLYLAISFLSCILSGGYFDRNG 163
Cdd:pfam07690 184 EEARLSLIVAWKALLRdpVLWLLLALLLFGFAFFGLLTYLPLYQeVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLG 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 164 S---IGLMCTGTVIYAGGLFALANCKSVWQFILAFsVCSGLGTGILMTPLIGTVA-TWFLKRRGIATSISTMGGSIGGIV 239
Cdd:pfam07690 264 RrrrLLLALLLLILAALGLLLLSLTLSSLWLLLAL-LLLGFGFGLVFPALNALVSdLAPKEERGTASGLYNTAGSLGGAL 342
|
..
gi 6324453 240 FP 241
Cdd:pfam07690 343 GP 344
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
95-244 |
4.12e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 42.59 E-value: 4.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 95 KAWLVVFGAFMGLVPVFGLINSLGAiesYISKHQLanISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVI 174
Cdd:cd17332 221 RPFLILLLAYLLYFLAFNIVNTVLV---YYFKYVL--GGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLL 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 175 YAGG--LFALANCKSVWqFILAFSVCSGLGTGIL------MTPLIGTVATWFLKRR--GIATSISTM----GGSIGGIVF 240
Cdd:cd17332 296 AILGllLLFFLPPGNLV-LILVLAVLAGIGYGGAnllpwaMLADVIDYGELKTGKRreGIFYSVMTFfrklGLALAGALV 374
|
....
gi 6324453 241 PIML 244
Cdd:cd17332 375 GLIL 378
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
131-430 |
4.63e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 42.54 E-value: 4.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 131 NISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYAGGLFALANCKSVWQFILAFSVCSGLGTGIlmTPL 210
Cdd:cd17324 30 GVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGF--WAI 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 211 IGTVATWFL--KRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQWAirilsFICLTCLICASVLARERTKPVVQPFKS 288
Cdd:cd17324 108 AAAYAADLVppEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAA-----FLAIAVLALLAALLLWRLLPSLPPKKP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 289 KAevakwyISSVFNWRYFLEGKFLFVAIGASFAESSLTSCA-TYLASYSMTR-GNTENVAYTMITASNAVGILGRYIPGY 366
Cdd:cd17324 183 GS------LGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALyTYLAPFLTDVpGFSSSAIIGLLLLFGVAGVVGSPLAGR 256
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6324453 367 FADKFIGRFNVEIITISMAALFNFvmwLPFGGNTKVLWAYVCLWGFSTGSILSLTPVCIGQISK 430
Cdd:cd17324 257 LADRGGRRALLIALLLLAAALLLL---TLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP 317
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
135-274 |
8.49e-04 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 41.64 E-value: 8.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 135 STISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYAGGLFALANCKSVWQFILAFSVCSGLGTGILMTPLIGTV 214
Cdd:cd17430 38 SDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASLGMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIML 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 215 ATWFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQWAIRILSFICLTCLICASVL 274
Cdd:cd17430 118 GRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGFLILGGLLLNCCTCGAVM 177
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
128-205 |
1.69e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.60 E-value: 1.69e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6324453 128 QLANISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYAGGLFALANCKSVWQFILAFsVCSGLGTGI 205
Cdd:cd17370 227 QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGF-ILWGLYMGA 303
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
229-423 |
1.73e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 40.67 E-value: 1.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 229 STMGGSIGGIVFPIMLRKL---YKEVGFQWAIRILSFICLTCLICASVLARERTKPVVQPfKSKAEVAKwYISSVFNWRY 305
Cdd:cd17332 145 ATIGGLLVTVLPPPLVAYFgggNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEE-KSKLPLLK-SLKALLKNRP 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 306 FLegKFLFVAIGASFAESSLTSCATYLASYSMTRGNTENVAYTMITASNAVGIlgryIPGYFADKFIGRFNVEIITISMA 385
Cdd:cd17332 223 FL--ILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLAL----LPWPPLKKRFGKKKAFFIGLLLA 296
|
170 180 190
....*....|....*....|....*....|....*...
gi 6324453 386 ALFNFVMWLPFGGNTKVLWAYVCLWGFSTGSILSLTPV 423
Cdd:cd17332 297 ILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWA 334
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
96-269 |
2.38e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 40.28 E-value: 2.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 96 AWLVVFGAFMGLVPVFGliNSLGAiesyiskhqlaniSSSTISWIFSLYLAISFLSCILSGGYF-DRNGSIGLMCTGTVI 174
Cdd:cd17490 206 QQMITFSTTFGFTPLIA--KQLGA-------------SSFQLGLLSIIYLLPNALASLLSGTLFyKKLGERNTIIIGFLL 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 175 YAGGLFALANCKSVWQFILAfSVCSGLGTGILMTPLIGTVATWF-LKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGF 253
Cdd:cd17490 271 LGAYCFLIPFAPNLTLLYLL-QALNGFGTGILFPLLMSLSIEGVpAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGL 349
|
170
....*....|....*.
gi 6324453 254 QWAIRILSFICLTCLI 269
Cdd:cd17490 350 QTGFFVIGVIALLAAI 365
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
132-413 |
3.95e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 39.67 E-value: 3.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 132 ISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYAGGLFALANCKSVWQFIlAFSVCSGLGTGILMTPLI 211
Cdd:TIGR00881 27 LSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMA-ALWALNGIFQGMGWPPCG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 212 GTVATWFLKR-RGIATSISTMGGSIGGIVFPIMLRKLYKE-VGFQWAIRILSFICLTCLICASVLARERTKPVVQP---- 285
Cdd:TIGR00881 106 RTVTKWFSRSeRGTWVSFWNCSHNVGGGLLPPLVLFGIAElYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPpaee 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 286 ----------FKSKAEVAKWYISSvfnwRYFLEGKFL-FVAIGASFAESSLTSCATYLASY-SMTRGNTENVAYTMITAS 353
Cdd:TIGR00881 186 mpneepdgdaEKKEEELTKKQIFL----QYVLLNKVLwYISLGYVFVYVVRTGILDWSPLYlTQEKGFSKEKASWAFTLY 261
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6324453 354 NAVGILGRYIPGYFADKFIGRFNVEIITISMAALF--NFVMWLPFGGNTKVLWAYVCLWGFS 413
Cdd:TIGR00881 262 ELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIvsLLVYWLNPAANPLMDLICLFALGFL 323
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
131-420 |
4.65e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 39.26 E-value: 4.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 131 NISSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMCTGTVIYAGGLFALANCKSVWQFiLAFSVCSGLGTGILMTPL 210
Cdd:TIGR00895 48 GLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQL-LILRFLAGLGLGGLMPNL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 211 IGTVAT-WFLKRRGIATSISTMGGSIGGIVFPIMLRKLYKEVGFQ--------------------------WAIRILSFI 263
Cdd:TIGR00895 127 NALVSEyAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRslfyvggiaplllllllmrflpesidFLVSKRPET 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 264 CLTCLICASVLARERTKPVVQPFKSKAEVAKWYISSVFNWRYFLEGKFLFVAIgaSFAESSLTSCATYLASYSMTRGNTE 343
Cdd:TIGR00895 207 VRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKALFQGKTARITVLLWLLY--FMLLVGVYFLTNWLPKLMVELGFSL 284
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6324453 344 NVAYTMITASNAVGILGRYIPGYFADKFigRFNVEIITISMAALFNFVMWLPFGGNTKVLWAYVCLWGFSTGSILSL 420
Cdd:TIGR00895 285 SLAATGGALFNFGGVIGSIIFGWLADRL--GPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGL 359
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
133-461 |
4.87e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.06 E-value: 4.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 133 SSSTISWIFSLYLAISFLSCILSGGYFDRNGSIGLMctgtvIYAG--------GLFALANcksVWQFILAFSVCSGLGTG 204
Cdd:cd17370 32 SAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPL-----VILGyglsalakPLLALAG---SWQLVLLLRILERLGKG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 205 ILMTP---LIGTVATWFLKRR--GIATSISTMGGSIGGIVFPIMLrkLYKEVGFQWAIrILSFICLTCLICASVLARERT 279
Cdd:cd17370 104 IRTPPrdaLLADATPPSGRGKafGLHRALDTLGAVLGPLLAALLL--YLLGGNYRTIF-LLAAIPALLALLILLFVVKEY 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 280 KPVVQPFKSKAEVAKWYISSVFnWRYFLeGKFLFVAIGASFAessltscatYLASYSMTRGNTENVAYTMITASNAVGIL 359
Cdd:cd17370 181 PRPPKLRKKSKKTSLKKLPKAF-WLYLL-AVALFALGNFSFA---------FLILRAQELGLSAALIPLLYALFNLVYAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324453 360 GRYIPGYFADKfIGRFNVEIITISMAALFNFVMWlpFGGNTKVLWAYVCLWGFSTGSILSLTPVCIGQISKTTDFGKRYA 439
Cdd:cd17370 250 AAYPAGRLSDR-IGRKKLLILGYLSLALAYLGFA--LGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYG 326
|
330 340
....*....|....*....|..
gi 6324453 440 TVYLLQALVTIPvlpiGGTLIG 461
Cdd:cd17370 327 LFNTVVGIGWLL----ASLIAG 344
|
|
| |
