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Conserved domains on  [gi|37362692|ref|NP_014545|]
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hexaprenyldihydroxybenzoate methyltransferase [Saccharomyces cerevisiae S288C]

Protein Classification

bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG( domain architecture ID 11493423)

bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG is a class I SAM-dependent methyltransferase that catalyzes both methylation steps in ubiquinone biosynthesis

CATH:  3.40.50.150
EC:  2.1.1.222|2.1.1.64
Gene Ontology:  GO:0102208|GO:0008425|GO:0032259|GO:0006744
PubMed:  10419476|11583838

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiG TIGR01983
ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase ...
 40-305 9.60e-113

ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase believed to act at two points in the ubiquinone biosynthetic pathway in bacteria (UbiG) and fungi (COQ3). A separate methylase (MenG/UbiE) catalyzes the single C-methylation step. The most commonly used names for genes in this family do not indicate whether this gene is an O-methyl, or C-methyl transferase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


:

Pssm-ID: 273910  Cd Length: 224  Bit Score: 325.40  E-value: 9.60e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692    40 EVKHFQELAPTWWDTDGSQRILHKMNLTRLDFVQRTVRNQVKiqnpeifvpgfnykeflpeyvcDNIQremqesietnld 119
Cdd:TIGR01983   1 EIAKFSALAHEWWDPNGKFKPLHKMNPLRLDYIRDRIRKNFK----------------------NPLD------------ 46

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692   120 krpEVSVLDVGCGGGILSESLARLKWvkNVQGIDLTRDCIMVAKEHAKKDPMlegKINYECKALEDVT----GQFDIITC 195
Cdd:TIGR01983  47 ---GLRVLDVGCGGGLLSEPLARLGA--NVTGIDASEENIEVAKLHAKKDPL---QIDYRCTTVEDLAekkaGSFDVVTC 118

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692   196 MEMLEHVDMPSEILRHCWSRLNPEkGILFLSTINRDLISWFTTIFMGENVLKIVPKGTHHLSKYINSKEILAWFNDNysg 275
Cdd:TIGR01983 119 MEVLEHVPDPQAFIRACAQLLKPG-GILFFSTINRTPKSYLLAIVGAEYILRIVPKGTHDWEKFIKPSELLSWLESA--- 194

                         250       260       270
                  ....*....|....*....|....*....|
gi 37362692   276 QFRLLDLKGTMYLPYQGWVEHDCSDVGNYF 305
Cdd:TIGR01983 195 GLRVKDIKGLVYNPIKNTWKLSKDTDVNYM 224
 
Name Accession Description Interval E-value
UbiG TIGR01983
ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase ...
 40-305 9.60e-113

ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase believed to act at two points in the ubiquinone biosynthetic pathway in bacteria (UbiG) and fungi (COQ3). A separate methylase (MenG/UbiE) catalyzes the single C-methylation step. The most commonly used names for genes in this family do not indicate whether this gene is an O-methyl, or C-methyl transferase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273910  Cd Length: 224  Bit Score: 325.40  E-value: 9.60e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692    40 EVKHFQELAPTWWDTDGSQRILHKMNLTRLDFVQRTVRNQVKiqnpeifvpgfnykeflpeyvcDNIQremqesietnld 119
Cdd:TIGR01983   1 EIAKFSALAHEWWDPNGKFKPLHKMNPLRLDYIRDRIRKNFK----------------------NPLD------------ 46

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692   120 krpEVSVLDVGCGGGILSESLARLKWvkNVQGIDLTRDCIMVAKEHAKKDPMlegKINYECKALEDVT----GQFDIITC 195
Cdd:TIGR01983  47 ---GLRVLDVGCGGGLLSEPLARLGA--NVTGIDASEENIEVAKLHAKKDPL---QIDYRCTTVEDLAekkaGSFDVVTC 118

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692   196 MEMLEHVDMPSEILRHCWSRLNPEkGILFLSTINRDLISWFTTIFMGENVLKIVPKGTHHLSKYINSKEILAWFNDNysg 275
Cdd:TIGR01983 119 MEVLEHVPDPQAFIRACAQLLKPG-GILFFSTINRTPKSYLLAIVGAEYILRIVPKGTHDWEKFIKPSELLSWLESA--- 194

                         250       260       270
                  ....*....|....*....|....*....|
gi 37362692   276 QFRLLDLKGTMYLPYQGWVEHDCSDVGNYF 305
Cdd:TIGR01983 195 GLRVKDIKGLVYNPIKNTWKLSKDTDVNYM 224
PLN02396 PLN02396
hexaprenyldihydroxybenzoate methyltransferase
 21-307 2.56e-36

hexaprenyldihydroxybenzoate methyltransferase


Pssm-ID: 178018 [Multi-domain]  Cd Length: 322  Bit Score: 132.93  E-value: 2.56e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692   21 SRFAIQTQTRCKSTDASEDEVKHFQELAPTWWDTDGSQRILHKMNLTRLDFVQRTVrnqvkiqnpeifvpgfnykeflpe 100
Cdd:PLN02396  61 GKASNKSRSTSTTTSLNEDELAKFSAIADTWWHSEGPFKPLHQMNPTRLAFIRSTL------------------------ 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692  101 yvCDNIQREMQESietnldkRP--EVSVLDVGCGGGILSESLARLKwvKNVQGIDLTRDCIMVAKEHAKKDPMlEGKINY 178
Cdd:PLN02396 117 --CRHFSKDPSSA-------KPfeGLKFIDIGCGGGLLSEPLARMG--ATVTGVDAVDKNVKIARLHADMDPV-TSTIEY 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692  179 ECKALE---DVTGQFDIITCMEMLEHVDMPSEILRHCwSRLNPEKGILFLSTINRDLISWFTTIFMGENVLKIVPKGTHH 255
Cdd:PLN02396 185 LCTTAEklaDEGRKFDAVLSLEVIEHVANPAEFCKSL-SALTIPNGATVLSTINRTMRAYASTIVGAEYILRWLPKGTHQ 263

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 37362692  256 LSKYINSKEILAWFNdnySGQFRLLDLKGTMYLPYQG-WVEHDcsDVGNYFMA 307
Cdd:PLN02396 264 WSSFVTPEELSMILQ---RASVDVKEMAGFVYNPITGrWLLSD--DISVNYIA 311
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 125-229 7.19e-28

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 104.71  E-value: 7.19e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692 125 SVLDVGCGGGILSESLARLKWvkNVQGIDLTRDCIMVAKEHAKkdpmlEGKINYECKALEDV---TGQFDIITCMEMLEH 201
Cdd:COG2227  27 RVLDVGCGTGRLALALARRGA--DVTGVDISPEALEIARERAA-----ELNVDFVQGDLEDLpleDGSFDLVICSEVLEH 99

                        90       100
                ....*....|....*....|....*...
gi 37362692 202 VDMPSEILRHCWSRLNPEkGILFLSTIN 229
Cdd:COG2227 100 LPDPAALLRELARLLKPG-GLLLLSTPN 126
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 94-272 3.95e-21

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 87.87  E-value: 3.95e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692    94 YKEFLPEYVCDNIQREMqesietnLDKRPEVSVLDVGCGGGILSESLArlKWVKNVQGIDLTRDCIMVAKEHAKKDPMLE 173
Cdd:pfam13489   1 YAHQRERLLADLLLRLL-------PKLPSPGRVLDFGCGTGIFLRLLR--AQGFSVTGVDPSPIAIERALLNVRFDQFDE 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692   174 GKINYEckaledvTGQFDIITCMEMLEHVDMPSEILRHCWSRLNPEkGILFLSTINRDL--ISWFTTIFMgenvlkIVPK 251
Cdd:pfam13489  72 QEAAVP-------AGKFDVIVAREVLEHVPDPPALLRQIAALLKPG-GLLLLSTPLASDeaDRLLLEWPY------LRPR 137

                         170       180
                  ....*....|....*....|.
gi 37362692   252 GTHHlsKYINSKEILAWFNDN 272
Cdd:pfam13489 138 NGHI--SLFSARSLKRLLEEA 156
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 126-226 4.38e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 50.51  E-value: 4.38e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692 126 VLDVGCGGGILSESLARLKwVKNVQGIDLTRDCIMVAKEHAKKDpmLEGKINYEC----KALEDVTGQFDIITCMEMLEH 201
Cdd:cd02440   2 VLDLGCGTGALALALASGP-GARVTGVDISPVALELARKAAAAL--LADNVEVLKgdaeELPPEADESFDVIISDPPLHH 78

                        90       100
                ....*....|....*....|....*.
gi 37362692 202 -VDMPSEILRHCWSRLNPeKGILFLS 226
Cdd:cd02440  79 lVEDLARFLEEARRLLKP-GGVLVLT 103
 
Name Accession Description Interval E-value
UbiG TIGR01983
ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase ...
 40-305 9.60e-113

ubiquinone biosynthesis O-methyltransferase; This model represents an O-methyltransferase believed to act at two points in the ubiquinone biosynthetic pathway in bacteria (UbiG) and fungi (COQ3). A separate methylase (MenG/UbiE) catalyzes the single C-methylation step. The most commonly used names for genes in this family do not indicate whether this gene is an O-methyl, or C-methyl transferase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273910  Cd Length: 224  Bit Score: 325.40  E-value: 9.60e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692    40 EVKHFQELAPTWWDTDGSQRILHKMNLTRLDFVQRTVRNQVKiqnpeifvpgfnykeflpeyvcDNIQremqesietnld 119
Cdd:TIGR01983   1 EIAKFSALAHEWWDPNGKFKPLHKMNPLRLDYIRDRIRKNFK----------------------NPLD------------ 46

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692   120 krpEVSVLDVGCGGGILSESLARLKWvkNVQGIDLTRDCIMVAKEHAKKDPMlegKINYECKALEDVT----GQFDIITC 195
Cdd:TIGR01983  47 ---GLRVLDVGCGGGLLSEPLARLGA--NVTGIDASEENIEVAKLHAKKDPL---QIDYRCTTVEDLAekkaGSFDVVTC 118

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692   196 MEMLEHVDMPSEILRHCWSRLNPEkGILFLSTINRDLISWFTTIFMGENVLKIVPKGTHHLSKYINSKEILAWFNDNysg 275
Cdd:TIGR01983 119 MEVLEHVPDPQAFIRACAQLLKPG-GILFFSTINRTPKSYLLAIVGAEYILRIVPKGTHDWEKFIKPSELLSWLESA--- 194

                         250       260       270
                  ....*....|....*....|....*....|
gi 37362692   276 QFRLLDLKGTMYLPYQGWVEHDCSDVGNYF 305
Cdd:TIGR01983 195 GLRVKDIKGLVYNPIKNTWKLSKDTDVNYM 224
PLN02396 PLN02396
hexaprenyldihydroxybenzoate methyltransferase
 21-307 2.56e-36

hexaprenyldihydroxybenzoate methyltransferase


Pssm-ID: 178018 [Multi-domain]  Cd Length: 322  Bit Score: 132.93  E-value: 2.56e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692   21 SRFAIQTQTRCKSTDASEDEVKHFQELAPTWWDTDGSQRILHKMNLTRLDFVQRTVrnqvkiqnpeifvpgfnykeflpe 100
Cdd:PLN02396  61 GKASNKSRSTSTTTSLNEDELAKFSAIADTWWHSEGPFKPLHQMNPTRLAFIRSTL------------------------ 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692  101 yvCDNIQREMQESietnldkRP--EVSVLDVGCGGGILSESLARLKwvKNVQGIDLTRDCIMVAKEHAKKDPMlEGKINY 178
Cdd:PLN02396 117 --CRHFSKDPSSA-------KPfeGLKFIDIGCGGGLLSEPLARMG--ATVTGVDAVDKNVKIARLHADMDPV-TSTIEY 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692  179 ECKALE---DVTGQFDIITCMEMLEHVDMPSEILRHCwSRLNPEKGILFLSTINRDLISWFTTIFMGENVLKIVPKGTHH 255
Cdd:PLN02396 185 LCTTAEklaDEGRKFDAVLSLEVIEHVANPAEFCKSL-SALTIPNGATVLSTINRTMRAYASTIVGAEYILRWLPKGTHQ 263

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 37362692  256 LSKYINSKEILAWFNdnySGQFRLLDLKGTMYLPYQG-WVEHDcsDVGNYFMA 307
Cdd:PLN02396 264 WSSFVTPEELSMILQ---RASVDVKEMAGFVYNPITGrWLLSD--DISVNYIA 311
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 125-229 7.19e-28

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 104.71  E-value: 7.19e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692 125 SVLDVGCGGGILSESLARLKWvkNVQGIDLTRDCIMVAKEHAKkdpmlEGKINYECKALEDV---TGQFDIITCMEMLEH 201
Cdd:COG2227  27 RVLDVGCGTGRLALALARRGA--DVTGVDISPEALEIARERAA-----ELNVDFVQGDLEDLpleDGSFDLVICSEVLEH 99

                        90       100
                ....*....|....*....|....*...
gi 37362692 202 VDMPSEILRHCWSRLNPEkGILFLSTIN 229
Cdd:COG2227 100 LPDPAALLRELARLLKPG-GLLLLSTPN 126
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 94-272 3.95e-21

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 87.87  E-value: 3.95e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692    94 YKEFLPEYVCDNIQREMqesietnLDKRPEVSVLDVGCGGGILSESLArlKWVKNVQGIDLTRDCIMVAKEHAKKDPMLE 173
Cdd:pfam13489   1 YAHQRERLLADLLLRLL-------PKLPSPGRVLDFGCGTGIFLRLLR--AQGFSVTGVDPSPIAIERALLNVRFDQFDE 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692   174 GKINYEckaledvTGQFDIITCMEMLEHVDMPSEILRHCWSRLNPEkGILFLSTINRDL--ISWFTTIFMgenvlkIVPK 251
Cdd:pfam13489  72 QEAAVP-------AGKFDVIVAREVLEHVPDPPALLRQIAALLKPG-GLLLLSTPLASDeaDRLLLEWPY------LRPR 137

                         170       180
                  ....*....|....*....|.
gi 37362692   252 GTHHlsKYINSKEILAWFNDN 272
Cdd:pfam13489 138 NGHI--SLFSARSLKRLLEEA 156
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 126-218 1.07e-15

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 71.44  E-value: 1.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692   126 VLDVGCGGGILSESLARLkWVKNVQGIDLTRDCIMVAKEHAKKDPMlegKINYECKALEDV---TGQFDIITCMEMLEHV 202
Cdd:pfam13649   1 VLDLGCGTGRLTLALARR-GGARVTGVDLSPEMLERARERAAEAGL---NVEFVQGDAEDLpfpDGSFDLVVSSGVLHHL 76

                          90
                  ....*....|....*...
gi 37362692   203 DMP--SEILRHCWSRLNP 218
Cdd:pfam13649  77 PDPdlEAALREIARVLKP 94
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 107-227 1.26e-14

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 69.96  E-value: 1.26e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692 107 QREMQESIETNLDKRPEVSVLDVGCGGGILSESLARLKWVKnVQGIDLTRDCIMVAKEHAKKDPmLEGKINYECKALEDV 186
Cdd:COG2230  36 QEAKLDLILRKLGLKPGMRVLDIGCGWGGLALYLARRYGVR-VTGVTLSPEQLEYARERAAEAG-LADRVEVRLADYRDL 113

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 37362692 187 --TGQFDIITCMEMLEHV--DMPSEILRHCWSRLNPEkGILFLST 227
Cdd:COG2230 114 paDGQFDAIVSIGMFEHVgpENYPAYFAKVARLLKPG-GRLLLHT 157
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 118-240 3.54e-14

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 68.48  E-value: 3.54e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692 118 LDKRPEVSVLDVGCGGGILSESLARLKWvkNVQGIDLTRDCIMVAKEHAKKDPMlegKINYECKALEDV---TGQFDIIT 194
Cdd:COG2226  18 LGLRPGARVLDLGCGTGRLALALAERGA--RVTGVDISPEMLELARERAAEAGL---NVEFVVGDAEDLpfpDGSFDLVI 92

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 37362692 195 CMEMLEHVDMPSEILRHCWSRLNPEkGILFLSTINRDLISWFTTIF 240
Cdd:COG2226  93 SSFVLHHLPDPERALAEIARVLKPG-GRLVVVDFSPPDLAELEELL 137
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 127-225 1.57e-13

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 65.38  E-value: 1.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692   127 LDVGCGGGILSESLARLkwVKNVQGIDLTRDCIMVAKEHAKKDPMLEGKINYECKALEDvtGQFDIITCMEMLEHVDMPS 206
Cdd:pfam08241   1 LDVGCGTGLLTELLARL--GARVTGVDISPEMLELAREKAPREGLTFVVGDAEDLPFPD--NSFDLVLSSEVLHHVEDPE 76

                          90
                  ....*....|....*....
gi 37362692   207 EILRHCWSRLNPEkGILFL 225
Cdd:pfam08241  77 RALREIARVLKPG-GILII 94
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
125-227 6.89e-12

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 60.99  E-value: 6.89e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692 125 SVLDVGCGGGILSESLARLKWVKNVQGIDLTRDCIMVAKEHAkkdpmleGKINYECKALEDVT--GQFDIITCMEMLEHV 202
Cdd:COG4106   4 RVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARL-------PNVRFVVADLRDLDppEPFDLVVSNAALHWL 76

                        90       100
                ....*....|....*....|....*
gi 37362692 203 DMPSEILRHCWSRLNPEkGILFLST 227
Cdd:COG4106  77 PDHAALLARLAAALAPG-GVLAVQV 100
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
125-227 1.53e-10

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 59.24  E-value: 1.53e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692 125 SVLDVGCGGGILSESLArlKWVKNVQGIDLTRDCIMVAKEHAKKDPMLEGKINyeckALEDVTGQFDIITCMEMLEHVDM 204
Cdd:COG4976  49 RVLDLGCGTGLLGEALR--PRGYRLTGVDLSEEMLAKAREKGVYDRLLVADLA----DLAEPDGRFDLIVAADVLTYLGD 122

                        90       100
                ....*....|....*....|...
gi 37362692 205 PSEILRHCWSRLNPEkGILFLST 227
Cdd:COG4976 123 LAAVFAGVARALKPG-GLFIFSV 144
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 127-223 3.36e-10

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 56.22  E-value: 3.36e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692   127 LDVGCGGGILSESLARLKWVKNVQGIDLTRDCIMVAKEHAKKDPMLEG-KINYECKALEDVTG-QFDIITCMEMLEHVDM 204
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAALGLLNAvRVELFQLDLGELDPgSFDVVVASNVLHHLAD 80

                          90
                  ....*....|....*....
gi 37362692   205 PSEILRHCWSRLNPEkGIL 223
Cdd:pfam08242  81 PRAVLRNIRRLLKPG-GVL 98
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 121-226 3.88e-10

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 58.39  E-value: 3.88e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692 121 RPEVSVLDVGCGGGILSESLARLKwVKNVQGIDLTRDCIMVAKEHAKKDPMleGKINYECKALEDV----TGQFDIITCM 196
Cdd:COG0500  25 PKGGRVLDLGCGTGRNLLALAARF-GGRVIGIDLSPEAIALARARAAKAGL--GNVEFLVADLAELdplpAESFDLVVAF 101

                        90       100       110
                ....*....|....*....|....*....|..
gi 37362692 197 EMLEHVD--MPSEILRHCWSRLNPEkGILFLS 226
Cdd:COG0500 102 GVLHHLPpeEREALLRELARALKPG-GVLLLS 132
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 122-201 1.22e-09

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 57.54  E-value: 1.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692  122 PEVSVLDVGCGGGILSESLARLKWvkNVQGIDLTRDCIMVAKEHAKKDPmLEGKINYECKALEDVTGQFDIITCMEMLEH 201
Cdd:PRK07580  63 TGLRILDAGCGVGSLSIPLARRGA--KVVASDISPQMVEEARERAPEAG-LAGNITFEVGDLESLLGRFDTVVCLDVLIH 139
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 126-226 4.38e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 50.51  E-value: 4.38e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692 126 VLDVGCGGGILSESLARLKwVKNVQGIDLTRDCIMVAKEHAKKDpmLEGKINYEC----KALEDVTGQFDIITCMEMLEH 201
Cdd:cd02440   2 VLDLGCGTGALALALASGP-GARVTGVDISPVALELARKAAAAL--LADNVEVLKgdaeELPPEADESFDVIISDPPLHH 78

                        90       100
                ....*....|....*....|....*.
gi 37362692 202 -VDMPSEILRHCWSRLNPeKGILFLS 226
Cdd:cd02440  79 lVEDLARFLEEARRLLKP-GGVLVLT 103
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
112-226 1.42e-07

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 51.71  E-value: 1.42e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692 112 ESIETNLdkRPEVSVLDVGCGGGILSeSLARLKWVKNVQGIDLTRDCIMVAKEHAKKDPmLEGKINYECKALEDvTGQFD 191
Cdd:COG2264 140 EALEKLL--KPGKTVLDVGCGSGILA-IAAAKLGAKRVLAVDIDPVAVEAARENAELNG-VEDRIEVVLGDLLE-DGPYD 214

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 37362692 192 IITC-------MEMLEHVdmpseilrhcWSRLNPEkGILFLS 226
Cdd:COG2264 215 LVVAnilanplIELAPDL----------AALLKPG-GYLILS 245
PRK06202 PRK06202
hypothetical protein; Provisional
 124-215 2.04e-07

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 50.77  E-value: 2.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692  124 VSVLDVGCGGGILSESLARlkWVK------NVQGIDLTRDCIMVAKEHAKKDpmlegKINYEC---KALEDVTGQFDIIT 194
Cdd:PRK06202  62 LTLLDIGCGGGDLAIDLAR--WARrdglrlEVTAIDPDPRAVAFARANPRRP-----GVTFRQavsDELVAEGERFDVVT 134

                         90       100
                 ....*....|....*....|...
gi 37362692  195 CMEMLEHVDMPS--EILRHCWSR 215
Cdd:PRK06202 135 SNHFLHHLDDAEvvRLLADSAAL 157
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 121-228 5.22e-07

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 50.34  E-value: 5.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692   121 RPEVSVLDVGCGGGILSESLARLKwVKNVQGIDLTRDCIMVAKEHAKKDPMLEgkiNYECKALEDV-TGQFDIITC---- 195
Cdd:pfam06325 160 KPGESVLDVGCGSGILAIAALKLG-AKKVVGVDIDPVAVRAAKENAELNGVEA---RLEVYLPGDLpKEKADVVVAnila 235

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 37362692   196 ---MEMLEHVdmpseilrhcWSRLNPEkGILFLSTI 228
Cdd:pfam06325 236 dplIELAPDI----------YALVKPG-GYLILSGI 260
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 120-226 1.31e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 47.41  E-value: 1.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692   120 KRPEVSVLDVGCGGGILSESLA-RLKWVKNVQGIDLTRDCIMVAKEHAKKDP-----MLEGKINYECKALEDvtGQFDII 193
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAeELGPNAEVVGIDISEEAIEKARENAQKLGfdnveFEQGDIEELPELLED--DKFDVV 78

                          90       100       110
                  ....*....|....*....|....*....|...
gi 37362692   194 TCMEMLEHVDMPSEILRHCWSRLNPEKGILFLS 226
Cdd:pfam13847  79 ISNCVLNHIPDPDKVLQEILRVLKPGGRLIISD 111
PLN02244 PLN02244
tocopherol O-methyltransferase
 108-212 7.08e-06

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 47.05  E-value: 7.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692  108 REMQES-----IETNLDKRPEvSVLDVGCGGGILSESLARlKWVKNVQGIDLTRDCIMVAKEHAKKDPmLEGKINYE-CK 181
Cdd:PLN02244 100 RMIEESlawagVPDDDEKRPK-RIVDVGCGIGGSSRYLAR-KYGANVKGITLSPVQAARANALAAAQG-LSDKVSFQvAD 176

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 37362692  182 AL----EDvtGQFDIITCMEMLEHvdMP------SEILRHC 212
Cdd:PLN02244 177 ALnqpfED--GQFDLVWSMESGEH--MPdkrkfvQELARVA 213
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
121-243 1.35e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 45.41  E-value: 1.35e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692 121 RPEVSVLDVGCGGGILSeSLARLKWVKNVQGIDLTRDCIMVAKEHAKKDPmLEGKIN-YECKALE-DVTGQFDIITCmEM 198
Cdd:COG4076  34 KPGDVVLDIGTGSGLLS-MLAARAGAKKVYAVEVNPDIAAVARRIIAANG-LSDRITvINADATDlDLPEKADVIIS-EM 110

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 37362692 199 LeHVDMPSE----ILRHCWSRLN-------PEKGILFLSTI--NRDLISWFTTIFMGE 243
Cdd:COG4076 111 L-DTALLDEgqvpILNHARKRLLkpggriiPERITNAAQPVesPVDAEGFEDWQFDGF 167
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 105-228 5.94e-05

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 43.43  E-value: 5.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692   105 NIQREMQESIETNLDKRPEV---SVLDVGCGGGILSESLARLKWVKNVQGIDLTRDCIMVAKEHAKKdpmlegKINYECK 181
Cdd:TIGR02072  14 KIQREMAKRLLALLKEKGIFipaSVLDIGCGTGYLTRALLKRFPQAEFIALDISAGMLAQAKTKLSE------NVQFICG 87

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 37362692   182 ALEDV---TGQFDIITCMEMLEHVDMPSEILRHCWSRLNPeKGILFLSTI 228
Cdd:TIGR02072  88 DAEKLpleDSSFDLIVSNLALQWCDDLSQALSELARVLKP-GGLLAFSTF 136
PRK14968 PRK14968
putative methyltransferase; Provisional
 117-194 8.59e-05

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 42.58  E-value: 8.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692  117 NLDKRPEVSVLDVGCGGGILSESLARLKwvKNVQGIDLTRDCIMVAKEHAKKDPMLEGKIN-YECKALEDVTG-QFDIIT 194
Cdd:PRK14968  18 NAVDKKGDRVLEVGTGSGIVAIVAAKNG--KKVVGVDINPYAVECAKCNAKLNNIRNNGVEvIRSDLFEPFRGdKFDVIL 95
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
112-228 1.24e-04

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 42.83  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692  112 ESIETNLdkRPEVSVLDVGCGGGILSeSLARLKWVKNVQGIDLTRDCIMVAKEHAKKDPMLEGkinyecKALEDVTGQFD 191
Cdd:PRK00517 111 EALEKLV--LPGKTVLDVGCGSGILA-IAAAKLGAKKVLAVDIDPQAVEAARENAELNGVELN------VYLPQGDLKAD 181

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 37362692  192 IITC-------MEMLEHVdmpseilrhcWSRLNPEkGILFLSTI 228
Cdd:PRK00517 182 VIVAnilanplLELAPDL----------ARLLKPG-GRLILSGI 214
prmA TIGR00406
ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an ...
 125-228 4.91e-04

ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an S-adenosyl-L-methionine-dependent methyltransferase required for the modification of ribosomal protein L11. This protein is found in bacteria and (with a probable transit peptide) in Arabidopsis. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273061  Cd Length: 288  Bit Score: 40.97  E-value: 4.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692   125 SVLDVGCGGGILSESLARLKwVKNVQGIDLTRDCIMVAKEHAKKD---PMLEGKINYECKALEdvtGQFDIITCMEMLEH 201
Cdd:TIGR00406 162 NVIDVGCGSGILSIAALKLG-AAKVVGIDIDPLAVESARKNAELNqvsDRLQVKLIYLEQPIE---GKADVIVANILAEV 237

                          90       100
                  ....*....|....*....|....*...
gi 37362692   202 -VDMPSEIlrhcwSRLNPEKGILFLSTI 228
Cdd:TIGR00406 238 iKELYPQF-----SRLVKPGGWLILSGI 260
PLN02585 PLN02585
magnesium protoporphyrin IX methyltransferase
 124-201 5.69e-04

magnesium protoporphyrin IX methyltransferase


Pssm-ID: 215319 [Multi-domain]  Cd Length: 315  Bit Score: 41.00  E-value: 5.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692  124 VSVLDVGCGGGILSESLARlkwvknvQGIDLTRDCI---MV------AKEHAKKDPMLEgKINYECKALEDVTGQFDIIT 194
Cdd:PLN02585 146 VTVCDAGCGTGSLAIPLAL-------EGAIVSASDIsaaMVaeaerrAKEALAALPPEV-LPKFEANDLESLSGKYDTVT 217


                 ....*..
gi 37362692  195 CMEMLEH 201
Cdd:PLN02585 218 CLDVLIH 224
PRK08317 PRK08317
hypothetical protein; Provisional
 118-210 5.73e-04

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 40.69  E-value: 5.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692  118 LDKRPEVSVLDVGCGGGILSESLARLkwVKN---VQGIDLTRDCIMVAKEHAKKDpmlEGKINYEC---KALEDVTGQFD 191
Cdd:PRK08317  15 LAVQPGDRVLDVGCGPGNDARELARR--VGPegrVVGIDRSEAMLALAKERAAGL---GPNVEFVRgdaDGLPFPDGSFD 89

                         90       100
                 ....*....|....*....|...
gi 37362692  192 IITCMEMLEHVDMP----SEILR 210
Cdd:PRK08317  90 AVRSDRVLQHLEDParalAEIAR 112
PRK11705 PRK11705
cyclopropane fatty acyl phospholipid synthase;
118-228 1.37e-03

cyclopropane fatty acyl phospholipid synthase;


Pssm-ID: 183282  Cd Length: 383  Bit Score: 39.83  E-value: 1.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692  118 LDKRPEVSVLDVGCGGGILSESLARLKWVKnVQGIDLTRDCIMVAKEHAKKDPmlegkINYECKALEDVTGQFDIITCME 197
Cdd:PRK11705 163 LQLKPGMRVLDIGCGWGGLARYAAEHYGVS-VVGVTISAEQQKLAQERCAGLP-----VEIRLQDYRDLNGQFDRIVSVG 236

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 37362692  198 MLEHVD-------MpsEILRHCwsrLNPEkGILFLSTI 228
Cdd:PRK11705 237 MFEHVGpknyrtyF--EVVRRC---LKPD-GLFLLHTI 268
Methyltransf_32 pfam13679
Methyltransferase domain; This family appears to be a methyltransferase domain.
 114-168 2.60e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 379330 [Multi-domain]  Cd Length: 138  Bit Score: 37.55  E-value: 2.60e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 37362692   114 IETNLDKRPEVSVLDVGCGGGILSESLARLKWVKNVQGIDLTRDCIMVAKEHAKK 168
Cdd:pfam13679  17 LKELLDENGPITIVDHGAGKGYLGFILYYLKYGVRVYGIDTRAELVEKANALAQK 71
metW TIGR02081
methionine biosynthesis protein MetW; This protein is found alongside MetX, of the enzyme that ...
 121-210 3.24e-03

methionine biosynthesis protein MetW; This protein is found alongside MetX, of the enzyme that acylates homoserine as a first step toward methionine biosynthesis, in many species. It appears to act in methionine biosynthesis but is not fully characterized. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 273958  Cd Length: 194  Bit Score: 38.12  E-value: 3.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692   121 RPEVSVLDVGCGGGILSESLARLKWVKNvQGIDLTRDCIMVAKehAKKDPMLEGKINYECKALEDvtGQFDIITCMEMLE 200
Cdd:TIGR02081  12 PPGSRVLDLGCGDGELLALLRDEKQVRG-YGIEIDQDGVLACV--ARGVNVIQGDLDEGLEAFPD--KSFDYVILSQTLQ 86

                          90
                  ....*....|
gi 37362692   201 HVDMPSEILR 210
Cdd:TIGR02081  87 ATRNPEEILD 96
PRK11036 PRK11036
tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;
112-225 3.99e-03

tRNA uridine 5-oxyacetic acid(34) methyltransferase CmoM;


Pssm-ID: 182918  Cd Length: 255  Bit Score: 38.02  E-value: 3.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692  112 ESIETNLDKRPeVSVLDVGCGGGILSESLARLKwvKNVQGIDLTRDCIMVAKEHAKKDPMLEgKINYECKALEDV----T 187
Cdd:PRK11036  35 DRLLAELPPRP-LRVLDAGGGEGQTAIKLAELG--HQVILCDLSAEMIQRAKQAAEAKGVSD-NMQFIHCAAQDIaqhlE 110

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 37362692  188 GQFDIITCMEMLEHVDMPSEILRHCWSRLNPeKGILFL 225
Cdd:PRK11036 111 TPVDLILFHAVLEWVADPKSVLQTLWSVLRP-GGALSL 147
MetW pfam07021
Methionine biosynthesis protein MetW; This family consists of several bacterial and one ...
 121-210 3.99e-03

Methionine biosynthesis protein MetW; This family consists of several bacterial and one archaeal methionine biosynthesis MetW proteins. Biosynthesis of methionine from homoserine in Pseudomonas putida takes place in three steps. The first step is the acylation of homoserine to yield an acyl-L-homoserine. This reaction is catalyzed by the products of the metXW genes and is equivalent to the first step in enterobacteria, gram-positive bacteria and fungi, except that in these microorganizms the reaction is catalyzed by a single polypeptide (the product of the metA gene in Escherichia coli and the met5 gene product in Neurospora crassa). In Pseudomonas putida, as in gram-positive bacteria and certain fungi, the second and third steps are a direct sulfhydrylation that converts the O-acyl-L-homoserine into homocysteine and further methylation to yield methionine. The latter reaction can be mediated by either of the two methionine synthetases present in the cells.


Pssm-ID: 399779  Cd Length: 193  Bit Score: 37.82  E-value: 3.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692   121 RPEVSVLDVGCGGGILSESLARLKWVKNvQGIDLTRDCIM--VAKE-HAKKDPMLEGKINYECKAledvtgqFDIITCME 197
Cdd:pfam07021  12 PPGSRVLDLGCGDGTLLYLLKEEKGVDG-YGIELDAAGVAecVAKGlYVIQGDLDEGLEHFPDKS-------FDYVILSQ 83

                          90
                  ....*....|...
gi 37362692   198 MLEHVDMPSEILR 210
Cdd:pfam07021  84 TLQATRNPREVLD 96
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 112-193 6.72e-03

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 37.45  E-value: 6.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692  112 ESIETNLDKRPEVSVLDVGCGGGILSESLARLKWVKNVQGIDLTRDCIMVAKEHAKKDpmLEGKIN-YECKALEDVT-GQ 189
Cdd:PRK09328  98 EWALEALLLKEPLRVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHG--LGARVEfLQGDWFEPLPgGR 175


                 ....
gi 37362692  190 FDII 193
Cdd:PRK09328 176 FDLI 179
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 94-202 8.21e-03

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 37.31  E-value: 8.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37362692    94 YKEFLPE---YVC------DNIQREMQES-IETNLDK---RPEVSVLDVGCGGGILSESLARLKWVkNVQGIDLTrdcim 160
Cdd:pfam02353  20 FALFLDPtmtYSCayferpDMTLEEAQQAkLDLILDKlglKPGMTLLDIGCGWGGLMRRAAERYDV-NVVGLTLS----- 93

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 37362692   161 vaKEHAKKDPMLEGKINYECKA------LEDVTGQFDIITCMEMLEHV 202
Cdd:pfam02353  94 --KNQYKLARKRVAAEGLARKVevllqdYRDFDEPFDRIVSVGMFEHV 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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