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Conserved domains on  [gi|6324513|ref|NP_014582|]
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glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2 [Saccharomyces cerevisiae S288C]

Protein Classification

glycerol-3-phosphate dehydrogenase family protein( domain architecture ID 11496765)

glycerol-3-phosphate dehydrogenase family protein is similar to human L-alpha-glycerol-3-phosphate dehydrogenase 1 (GPD1), which catalyzes the reversible biological conversion of dihydroxyacetone (DHAP) to glycerol-3-phosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 85-432 0e+00

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


:

Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 573.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513     85 KVTVIGSGNWGTTIAKVIAENTELHSHIFEPEVRMWVFDEKIGDENLTDIINTRHQNVKYLPNIDLPHNLVADPDLLHSI 164
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALPELFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513    165 KGADILVFNIPHQFLPNIVKQLQGHVAPHVRAISCLKGFELGSKGVQLLSSYVTDELGIQCGALSGANLAPEVAKEHWSE 244
Cdd:TIGR03376  81 KGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513    245 TTVAYQLPKDYqgdgkDVDHKILKLLFHRPYFHVNVIDDVAGISIAGALKNVVALACGFVEGMGWGNNASAAIQRLGLGE 324
Cdd:TIGR03376 161 TTVGYRDPADF-----DVDARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLE 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513    325 IIKFGRMFFPESKVETyYQESAGVADLITTCSGGRNVKVATYMAKTGKSALEAEKELLNGQSAQGIITCREVHEWLQTCE 404
Cdd:TIGR03376 236 MIKFARMFFPTGEVTF-TFESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKN 314

                         330       340
                  ....*....|....*....|....*...
gi 6324513    405 LTQEFPLFEAVYQIVYNNVRMEDLPEMI 432
Cdd:TIGR03376 315 KDDEFPLFEAVYQILYEGLPPKKLPECL 342
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 85-432 0e+00

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 573.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513     85 KVTVIGSGNWGTTIAKVIAENTELHSHIFEPEVRMWVFDEKIGDENLTDIINTRHQNVKYLPNIDLPHNLVADPDLLHSI 164
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALPELFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513    165 KGADILVFNIPHQFLPNIVKQLQGHVAPHVRAISCLKGFELGSKGVQLLSSYVTDELGIQCGALSGANLAPEVAKEHWSE 244
Cdd:TIGR03376  81 KGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513    245 TTVAYQLPKDYqgdgkDVDHKILKLLFHRPYFHVNVIDDVAGISIAGALKNVVALACGFVEGMGWGNNASAAIQRLGLGE 324
Cdd:TIGR03376 161 TTVGYRDPADF-----DVDARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLE 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513    325 IIKFGRMFFPESKVETyYQESAGVADLITTCSGGRNVKVATYMAKTGKSALEAEKELLNGQSAQGIITCREVHEWLQTCE 404
Cdd:TIGR03376 236 MIKFARMFFPTGEVTF-TFESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKN 314

                         330       340
                  ....*....|....*....|....*...
gi 6324513    405 LTQEFPLFEAVYQIVYNNVRMEDLPEMI 432
Cdd:TIGR03376 315 KDDEFPLFEAVYQILYEGLPPKKLPECL 342
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 78-435 7.97e-150

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 430.21  E-value: 7.97e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513    78 HLKRAPFKVTVIGSGNWGTTIAKVIAENTElHSHIFEPEVRMWVFDEKIGDENLTDIINTRHQNVKYLPNIDLPHNLVAD 157
Cdd:PTZ00345   6 KLRCGPLKVSVIGSGNWGSAISKVVGENTQ-RNYIFHNEVRMWVLEEIVEGEKLSDIINTKHENVKYLPGIKLPDNIVAV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513   158 PDLLHSIKGADILVFNIPHQFLPNIVKQLQ--GHVAPHVRAISCLKGFELGSKGVQLLSSYVTDELGIQCGALSGANLAP 235
Cdd:PTZ00345  85 SDLKEAVEDADLLIFVIPHQFLESVLSQIKenNNLKKHARAISLTKGIIVENGKPVLCSDVIEEELGIPCCALSGANVAN 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513   236 EVAKEHWSETTVAYqlpKDYQgdgkdvDHKILKLLFHRPYFHVNVIDDVAGISIAGALKNVVALACGFVEGMGWGNNASA 315
Cdd:PTZ00345 165 DVAREEFSEATIGC---EDKD------DALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKS 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513   316 AIQRLGLGEIIKFGRMFFPESKVETYYqESAGVADLITTCSGGRNVKVATYMAKTG--KSALEAEKELLNGQSAQGIITC 393
Cdd:PTZ00345 236 AIIRIGLEEMKLFGKIFFPNVMDETFF-ESCGLADLITTCLGGRNVRCAAEFAKRNgkKSWEEIEAELLNGQKLQGTVTL 314

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 6324513   394 REVHEWLQTCELTQEFPLFEAVYQIVYNNvrmEDLPEMIEEL 435
Cdd:PTZ00345 315 KEVYEVLESHDLKKEFPLFTVTYKIAFEG---ADPSSLIDVL 353
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 85-435 5.06e-84

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 260.74  E-value: 5.06e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513   85 KVTVIGSGNWGTTIAKVIAENTElhshifepEVRMWVFDEKIGDEnltdiINTRHQNVKYLPNIDLPHNLVADPDLLHSI 164
Cdd:COG0240   2 KIAVLGAGSWGTALAKVLARNGH--------EVTLWGRDPEVAEE-----INETRENPRYLPGVKLPENLRATSDLEEAL 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513  165 KGADILVFNIPHQFLPNIVKQLQGHVAPHVRAISCLKGFELGSKgvQLLSSYVTDELG--IQCGALSGANLAPEVAKEHW 242
Cdd:COG0240  69 AGADLVLLAVPSQALREVLEQLAPLLPPGAPVVSATKGIEPGTG--LLMSEVIAEELPgaLRIAVLSGPSFAEEVARGLP 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513  243 SETTVAyqlpkdyqgdGKDVDH-KILKLLFHRPYFHVNVIDDVAGISIAGALKNVVALACGFVEGMGWGNNASAA-IQRl 320
Cdd:COG0240 147 TAVVVA----------SEDEEVaERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAAlITR- 215

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513  321 GLGEIIKFGRMFfpESKVETYYqESAGVADLITTCSG--GRNVKVATYMAKtGKSALEAEKELlnGQSAQGIITCREVHE 398
Cdd:COG0240 216 GLAEMTRLGVAL--GARPETFM-GLAGLGDLVLTCTSdlSRNRRFGLALGK-GKSLEEALAEM--GMVAEGVYTAKAVYE 289

                       330       340       350
                ....*....|....*....|....*....|....*..
gi 6324513  399 WLQtcELTQEFPLFEAVYQIVYNNVrmeDLPEMIEEL 435
Cdd:COG0240 290 LAE--KLGVEMPITEAVYAVLYEGK---SPREAVEAL 321
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 85-250 3.06e-63

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 201.27  E-value: 3.06e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513     85 KVTVIGSGNWGTTIAKVIAENTelhshifePEVRMWVFDEKigdenLTDIINTRHQNVKYLPNIDLPHNLVADPDLLHSI 164
Cdd:pfam01210   1 KIAVLGAGSWGTALAKVLADNG--------HEVRLWGRDEE-----LIEEINTTHENVRYLPGIKLPENLKATTDLAEAL 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513    165 KGADILVFNIPHQFLPNIVKQLQGHVAPHVRAISCLKGFELGSKgvQLLSSYVTDELGIQ--CGALSGANLAPEVAKEHW 242
Cdd:pfam01210  68 KGADIIVIVVPSQALREVLKQLKGLLKPDAILVSLSKGIEPGTL--KLLSEVIEEELGIQppIAVLSGPSHAEEVAQGLP 145


                  ....*...
gi 6324513    243 SETTVAYQ 250
Cdd:pfam01210 146 TATVIASK 153
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 85-432 0e+00

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 573.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513     85 KVTVIGSGNWGTTIAKVIAENTELHSHIFEPEVRMWVFDEKIGDENLTDIINTRHQNVKYLPNIDLPHNLVADPDLLHSI 164
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALPELFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513    165 KGADILVFNIPHQFLPNIVKQLQGHVAPHVRAISCLKGFELGSKGVQLLSSYVTDELGIQCGALSGANLAPEVAKEHWSE 244
Cdd:TIGR03376  81 KGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513    245 TTVAYQLPKDYqgdgkDVDHKILKLLFHRPYFHVNVIDDVAGISIAGALKNVVALACGFVEGMGWGNNASAAIQRLGLGE 324
Cdd:TIGR03376 161 TTVGYRDPADF-----DVDARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLE 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513    325 IIKFGRMFFPESKVETyYQESAGVADLITTCSGGRNVKVATYMAKTGKSALEAEKELLNGQSAQGIITCREVHEWLQTCE 404
Cdd:TIGR03376 236 MIKFARMFFPTGEVTF-TFESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKN 314

                         330       340
                  ....*....|....*....|....*...
gi 6324513    405 LTQEFPLFEAVYQIVYNNVRMEDLPEMI 432
Cdd:TIGR03376 315 KDDEFPLFEAVYQILYEGLPPKKLPECL 342
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 78-435 7.97e-150

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 430.21  E-value: 7.97e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513    78 HLKRAPFKVTVIGSGNWGTTIAKVIAENTElHSHIFEPEVRMWVFDEKIGDENLTDIINTRHQNVKYLPNIDLPHNLVAD 157
Cdd:PTZ00345   6 KLRCGPLKVSVIGSGNWGSAISKVVGENTQ-RNYIFHNEVRMWVLEEIVEGEKLSDIINTKHENVKYLPGIKLPDNIVAV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513   158 PDLLHSIKGADILVFNIPHQFLPNIVKQLQ--GHVAPHVRAISCLKGFELGSKGVQLLSSYVTDELGIQCGALSGANLAP 235
Cdd:PTZ00345  85 SDLKEAVEDADLLIFVIPHQFLESVLSQIKenNNLKKHARAISLTKGIIVENGKPVLCSDVIEEELGIPCCALSGANVAN 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513   236 EVAKEHWSETTVAYqlpKDYQgdgkdvDHKILKLLFHRPYFHVNVIDDVAGISIAGALKNVVALACGFVEGMGWGNNASA 315
Cdd:PTZ00345 165 DVAREEFSEATIGC---EDKD------DALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKS 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513   316 AIQRLGLGEIIKFGRMFFPESKVETYYqESAGVADLITTCSGGRNVKVATYMAKTG--KSALEAEKELLNGQSAQGIITC 393
Cdd:PTZ00345 236 AIIRIGLEEMKLFGKIFFPNVMDETFF-ESCGLADLITTCLGGRNVRCAAEFAKRNgkKSWEEIEAELLNGQKLQGTVTL 314

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 6324513   394 REVHEWLQTCELTQEFPLFEAVYQIVYNNvrmEDLPEMIEEL 435
Cdd:PTZ00345 315 KEVYEVLESHDLKKEFPLFTVTYKIAFEG---ADPSSLIDVL 353
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 85-435 5.06e-84

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 260.74  E-value: 5.06e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513   85 KVTVIGSGNWGTTIAKVIAENTElhshifepEVRMWVFDEKIGDEnltdiINTRHQNVKYLPNIDLPHNLVADPDLLHSI 164
Cdd:COG0240   2 KIAVLGAGSWGTALAKVLARNGH--------EVTLWGRDPEVAEE-----INETRENPRYLPGVKLPENLRATSDLEEAL 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513  165 KGADILVFNIPHQFLPNIVKQLQGHVAPHVRAISCLKGFELGSKgvQLLSSYVTDELG--IQCGALSGANLAPEVAKEHW 242
Cdd:COG0240  69 AGADLVLLAVPSQALREVLEQLAPLLPPGAPVVSATKGIEPGTG--LLMSEVIAEELPgaLRIAVLSGPSFAEEVARGLP 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513  243 SETTVAyqlpkdyqgdGKDVDH-KILKLLFHRPYFHVNVIDDVAGISIAGALKNVVALACGFVEGMGWGNNASAA-IQRl 320
Cdd:COG0240 147 TAVVVA----------SEDEEVaERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAAlITR- 215

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513  321 GLGEIIKFGRMFfpESKVETYYqESAGVADLITTCSG--GRNVKVATYMAKtGKSALEAEKELlnGQSAQGIITCREVHE 398
Cdd:COG0240 216 GLAEMTRLGVAL--GARPETFM-GLAGLGDLVLTCTSdlSRNRRFGLALGK-GKSLEEALAEM--GMVAEGVYTAKAVYE 289

                       330       340       350
                ....*....|....*....|....*....|....*..
gi 6324513  399 WLQtcELTQEFPLFEAVYQIVYNNVrmeDLPEMIEEL 435
Cdd:COG0240 290 LAE--KLGVEMPITEAVYAVLYEGK---SPREAVEAL 321
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
85-435 3.07e-73

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 232.65  E-value: 3.07e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513    85 KVTVIGSGNWGTTIAKVIAENtelhSHifepEVRMWVFDEKIGDEnltdiINTRHQNVKYLPNIDLPHNLVADPDLLHSI 164
Cdd:PRK00094   3 KIAVLGAGSWGTALAIVLARN----GH----DVTLWARDPEQAAE-----INADRENPRYLPGIKLPDNLRATTDLAEAL 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513   165 KGADILVFNIPHQFLPNIVKQLQGHVAPHVRAISCLKGFELGSKgvQLLSSYVTDELG--IQCGALSGANLAPEVAKEHW 242
Cdd:PRK00094  70 ADADLILVAVPSQALREVLKQLKPLLPPDAPIVWATKGIEPGTG--KLLSEVLEEELPdlAPIAVLSGPSFAKEVARGLP 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513   243 SETTVAyqlpkdyqGDGKDVDHKILKlLFHRPYFHVNVIDDVAGISIAGALKNVVALACGFVEGMGWGNNASAA-IQRlG 321
Cdd:PRK00094 148 TAVVIA--------STDEELAERVQE-LFHSPYFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAAlITR-G 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513   322 LGEIIKFGRMFfpESKVETYYqESAGVADLITTCSG--GRNVKVATYMAKtGKSALEAEKELlnGQSAQGIITCREVHEW 399
Cdd:PRK00094 218 LAEITRLGVAL--GANPETFL-GLAGLGDLVLTCTSplSRNRRFGLALGQ-GKSLEEALAEI--GMVAEGVRTAKAVYEL 291

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 6324513   400 LQtcELTQEFPLFEAVYQIVYNNVrmeDLPEMIEEL 435
Cdd:PRK00094 292 AK--KLGVEMPITEAVYAVLYEGK---DPREAVEDL 322
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 85-250 3.06e-63

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 201.27  E-value: 3.06e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513     85 KVTVIGSGNWGTTIAKVIAENTelhshifePEVRMWVFDEKigdenLTDIINTRHQNVKYLPNIDLPHNLVADPDLLHSI 164
Cdd:pfam01210   1 KIAVLGAGSWGTALAKVLADNG--------HEVRLWGRDEE-----LIEEINTTHENVRYLPGIKLPENLKATTDLAEAL 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513    165 KGADILVFNIPHQFLPNIVKQLQGHVAPHVRAISCLKGFELGSKgvQLLSSYVTDELGIQ--CGALSGANLAPEVAKEHW 242
Cdd:pfam01210  68 KGADIIVIVVPSQALREVLKQLKGLLKPDAILVSLSKGIEPGTL--KLLSEVIEEELGIQppIAVLSGPSHAEEVAQGLP 145


                  ....*...
gi 6324513    243 SETTVAYQ 250
Cdd:pfam01210 146 TATVIASK 153
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 283-430 5.29e-57

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 184.51  E-value: 5.29e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513    283 DVAGISIAGALKNVVALACGFVEGMGWGNNASAAIQRLGLGEIIKFGRMFFpeSKVETYYqESAGVADLITTCSGG--RN 360
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALG--AKPETFF-GLAGLGDLIVTCTSGlsRN 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513    361 VKVATYMAKtGKSALEAEKELlnGQSAQGIITCREVHEWLQTCELtqEFPLFEAVYQIVYNNVRMEDLPE 430
Cdd:pfam07479  78 RRFGEALGK-GKSLEEAEKEL--GQVAEGVYTAKAVYELAKKLGV--EMPIFEAVYRILYEGKSPEEALE 142
PRK12439 PRK12439
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 76-398 1.28e-42

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 171500 [Multi-domain]  Cd Length: 341  Bit Score: 153.40  E-value: 1.28e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513    76 IVHLKRAPfKVTVIGSGNWGTTIAKVIAENTelhshifePEVrMWVFDEKIGDEnltdiINTRHQNVKYLPN-IDLPHNL 154
Cdd:PRK12439   1 MAAAKREP-KVVVLGGGSWGTTVASICARRG--------PTL-QWVRSAETADD-----INDNHRNSRYLGNdVVLSDTL 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513   155 VADPDLLHSIKGADILVFNIPHQFLPNIVKQLQGHVAPHVRAISCLKGFELGSKgvQLLSSYVTDEL-GIQCGALSGANL 233
Cdd:PRK12439  66 RATTDFAEAANCADVVVMGVPSHGFRGVLTELAKELRPWVPVVSLVKGLEQGTN--MRMSQIIEEVLpGHPAGILAGPNI 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513   234 APEVAKEHWSETTVAyqLPKDYQGDGkdvdhkiLKLLFHRPYFHVNVIDDVAGISIAGALKNVVALACGFVEGMGWGNNA 313
Cdd:PRK12439 144 AREVAEGYAAAAVLA--MPDQHLATR-------LSPLFRTRRFRVYTTDDVVGVEMAGALKNVFAIAVGMGYSLGIGENT 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513   314 SAAIQRLGLGEIIKFGRMFfpESKVETyYQESAGVADLITTCSG--GRNVKVATYMAKtGKSALEAEKELlnGQSAQGII 391
Cdd:PRK12439 215 RAMVIARALREMTKLGVAM--GGNPET-FAGLAGMGDLIVTCTSqrSRNRHVGEQLGA-GKPIDEIIASM--NQVAEGVK 288


                 ....*..
gi 6324513   392 TCREVHE 398
Cdd:PRK12439 289 AASVVME 295
PRK14618 PRK14618
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 86-420 7.16e-35

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237770 [Multi-domain]  Cd Length: 328  Bit Score: 131.92  E-value: 7.16e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513    86 VTVIGSGNWGTTIAKVIAENTElhshifepEVRMWV----FDEKIGDEnltdiintrHQNVKYLPNIDLPHNLVADPDLL 161
Cdd:PRK14618   7 VAVLGAGAWGTALAVLAASKGV--------PVRLWArrpeFAAALAAE---------RENREYLPGVALPAELYPTADPE 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513   162 HSIKGADILVFNIPHQFLPNIVKQLqghvaPHVRAI-SCLKGFELGSKGVQLLSSYVTDELGIQCGALSGANLAPEVAKE 240
Cdd:PRK14618  70 EALAGADFAVVAVPSKALRETLAGL-----PRALGYvSCAKGLAPDGGRLSELARVLEFLTQARVAVLSGPNHAEEIARF 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513   241 HWSETTVAYQLPkdyqgdgkDVDHKIlKLLFHRPYFHVNVIDDVAGISIAGALKNVVALACGFVEGMGWGNNASAAIQRL 320
Cdd:PRK14618 145 LPAATVVASPEP--------GLARRV-QAAFSGPSFRVYTSRDRVGVELGGALKNVIALAAGMVDGLKLGDNAKAALITR 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513   321 GLGEIIKFGRMFFPESkvETYYQESaGVADLITTCSG--GRNVKVATYMAK-TGKSALEAEkellnGQSAQGIITCREVH 397
Cdd:PRK14618 216 GLREMVRFGVALGAEE--ATFYGLS-GLGDLIATATSphSRNRAAGEAIVRgVDREHLEAG-----GKVVEGLYTVKALD 287

                        330       340
                 ....*....|....*....|...
gi 6324513   398 EWLQtcELTQEFPLFEAVYQIVY 420
Cdd:PRK14618 288 AWAK--AHGHDLPIVEAVARVAR 308
PRK14620 PRK14620
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 85-427 3.25e-25

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 173083 [Multi-domain]  Cd Length: 326  Bit Score: 105.30  E-value: 3.25e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513    85 KVTVIGSGNWGTTIAKVIAENtelhshifEPEVRMWVFDEKIgdenlTDIINTRHQNVKYLPNIDLPHNLVADPDLLHSI 164
Cdd:PRK14620   2 KISILGAGSFGTAIAIALSSK--------KISVNLWGRNHTT-----FESINTKRKNLKYLPTCHLPDNISVKSAIDEVL 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513   165 KG-ADILVFNIPHQFLPNIVKQLQG-HVAPHVRAISCLKGFELGSkgVQLLSSYVTDELGIQCGA-LSGANLAPEVAKEH 241
Cdd:PRK14620  69 SDnATCIILAVPTQQLRTICQQLQDcHLKKNTPILICSKGIEKSS--LKFPSEIVNEILPNNPIAiLSGPSFAKEIAEKL 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513   242 WSETTVAYQlpKDYQGDG--KDVDHKILKLLFHRpyfhvnvidDVAGISIAGALKNVVALACGFVEGMGWGNNASAAIQR 319
Cdd:PRK14620 147 PCSIVLAGQ--NETLGSSliSKLSNENLKIIYSQ---------DIIGVQIGAALKNIIAIACGIVLGKNLGNNAHAAVIT 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513   320 LGLGEI----------IKFGRMFFPeskvetyyqesAGVADLITTCSG--GRNVkvaTYMAKTGKSA-----LEAEKELL 382
Cdd:PRK14620 216 KGMNEIktlysakngsIDLNTLIGP-----------SCLGDLILTCTTlhSRNM---SFGFKIGNGFninqiLSEGKSVI 281

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 6324513   383 NGQS-AQGIITCREvhewlqtcELTQEFPLFEAVYQIVYNNVRMED 427
Cdd:PRK14620 282 EGFStVKPLISLAK--------KLNIELPICESIYNLLYENISLEK 319
PRK14619 PRK14619
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 83-394 4.12e-24

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237771 [Multi-domain]  Cd Length: 308  Bit Score: 101.60  E-value: 4.12e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513    83 PFKVTVIGSGNWGTTIAKVIAENTElhshifepEVRMWvfdekigdenltdiinTRHQNvkylpnidlphnlvadPDLLH 162
Cdd:PRK14619   4 PKTIAILGAGAWGSTLAGLASANGH--------RVRVW----------------SRRSG----------------LSLAA 43

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513   163 SIKGADILVFNIPHQFLPNIVKQLQG-HVAPHVRAISCLKGFELGS--KGVQLLSSYVTDELGIqcgALSGANLAPEVAK 239
Cdd:PRK14619  44 VLADADVIVSAVSMKGVRPVAEQVQAlNLPPETIIVTATKGLDPETtrTPSQIWQAAFPNHPVV---VLSGPNLSKEIQQ 120

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6324513   240 EHWSETTVAyqlpkdyqgdGKDVDH-KILKLLFHRPYFHVNVIDDVAGISIAGALKNVVALACGFVEGMGWGNNASAAIQ 318
Cdd:PRK14619 121 GLPAATVVA----------SRDLAAaETVQQIFSSERFRVYTNSDPLGTELGGTLKNVIAIAAGVCDGLQLGTNAKAALV 190

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6324513   319 RLGLGEIIKFGRMFfpESKVETYYQESaGVADLITTCSG--GRNVKVATYMAKtGKSaLEAEKELLNGqSAQGIITCR 394
Cdd:PRK14619 191 TRALPEMIRVGTHL--GAQTETFYGLS-GLGDLLATCTSplSRNYQVGYGLAQ-GKS-LEQILAELEG-TAEGVNTAN 262
GPD_NAD_C_bact pfam20618
Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent ...
 346-415 9.67e-03

Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent glycerol-3-phosphate dehydrogenase (GPD) from bacteria and archaea. GPD catalyzes the reversible reduction of dihydroxyacetone phosphate to glycerol-3-phosphate.


Pssm-ID: 466767 [Multi-domain]  Cd Length: 66  Bit Score: 34.78  E-value: 9.67e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6324513    346 AGVADLITTCSGG--RNVKVATYMAKtGKSaleaEKELLNGQSAQGIITCREVHEWL-QTCELtqEFPLFEAV 415
Cdd:pfam20618   1 AGLGDLVLTCTSDlsRNRTFGLLLGK-GMT----LAEAGNGQVAEGVRTAKAVAAILaRAHNV--EMPILEAV 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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